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https://www.readbyqxmd.com/read/28542301/electronic-cigarette-aerosols-suppress-cellular-antioxidant-defenses-and-induce-significant-oxidative-dna-damage
#1
Vengatesh Ganapathy, Jimmy Manyanga, Lacy Brame, Dehra McGuire, Balaji Sadhasivam, Evan Floyd, David A Rubenstein, Ilangovan Ramachandran, Theodore Wagener, Lurdes Queimado
BACKGROUND: Electronic cigarette (EC) aerosols contain unique compounds in addition to toxicants and carcinogens traditionally found in tobacco smoke. Studies are warranted to understand the public health risks of ECs. OBJECTIVE: The aim of this study was to determine the genotoxicity and the mechanisms induced by EC aerosol extracts on human oral and lung epithelial cells. METHODS: Cells were exposed to EC aerosol or mainstream smoke extracts and DNA damage was measured using the primer anchored DNA damage detection assay (q-PADDA) and 8-oxo-dG ELISA assay...
2017: PloS One
https://www.readbyqxmd.com/read/28541868/perceptions-of-harm-to-children-exposed-to-secondhand-aerosol-from-electronic-vapor-products-styles-survey-2015
#2
Kimberly H Nguyen, Van T Tong, Kristy Marynak, Brian A King
INTRODUCTION: The US Surgeon General has concluded that e-cigarette aerosol is not harmless and can contain harmful and potentially harmful chemicals, including nicotine. We assessed factors associated with adults' perceptions of harm related to children's exposure to secondhand aerosol from electronic vapor products (EVPs). METHODS: Data came from the 2015 Styles, an Internet panel survey of US adults aged 18 years or older (n = 4,127). Respondents were asked whether they believe aerosol from other people's EVPs causes children harm...
May 25, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28531448/electronic-cigarette-use-in-young-people-in-great-britain-2015-2016
#3
B Eastwood, K East, L S Brose, M J Dockrell, D Arnott, H Cheeseman, A McNeill
No abstract text is available yet for this article.
May 19, 2017: Public Health
https://www.readbyqxmd.com/read/28528750/electronic-cigarette-use-in-the-uk
#4
Talha Khan Burki
No abstract text is available yet for this article.
May 18, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28528203/changes-in-resting-state-functional-brain-connectivity-and-withdrawal-symptoms-are-associated-with-acute-electronic-cigarette-use
#5
Andréa L Hobkirk, Travis T Nichols, Jonathan Foulds, Jessica M Yingst, Susan Veldheer, Shari Hrabovsky, John Richie, Thomas Eissenberg, Stephen J Wilson
Resting state functional brain connectivity (rsFC) may be an important neuromarker of smoking behavior. Prior research has shown, among cigarette smokers, that nicotine administration alters rsFC within frontal and parietal cortices involved in executive control, as well as striatal regions that drive reward processing. These changes in rsFC have been associated with reductions in withdrawal symptom severity. We currently have a limited understanding of how rsFC is affected by the use of electronic cigarettes (ecigs), an increasingly popular class of products, the members of which deliver nicotine with varying effectiveness...
May 17, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28525609/e-cigarettes-and-weight-loss-product-design-innovation-insights-from-industry-patents
#6
Harkirat Singh, Ryan David Kennedy, Lisa Lagasse, Lauren M Czaplicki, Joanna E Cohen
Objective: There is emerging evidence that e-cigarettes are being used by some to mitigate weight gain after quitting smoking, and being used to help control weight. This study sought to identify and describe patents related to innovations for e-cigarette devices associated and weight loss. Methods: Relevant patents were identified using Google Patents with the core search terms: "electronic cigarette" OR "e-cigarette" OR "vaporizer" OR "vapourizer" AND "nicotine" AND "weight loss" OR "weight control" OR "obesity" OR "hunger"...
May 19, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28522563/biomarkers-of-exposure-to-new-and-emerging-tobacco-and-nicotine-delivery-products
#7
Suzaynn F Schick, Benjamin C Blount, Peyton Jacob, Najat A Saliba, John T Bernert, Ahmad El Hellani, Peter Jatlow, R Steve Pappas, Lanqing Wang, Jonathan Foulds, Arunava Ghosh, Stephen S Hecht, John C Gomez, Jessica R Martin, Clementina Mesaros, Sanjay Srivastava, Gideon St Helen, Robert Tarran, Pawel K Lorkiewicz, Ian A Blair, Heather L Kimmel, Claire M Doerschuk, Neal L Benowitz, Aruni Bhatnagar
Accurate and reliable measurements of exposure to tobacco products are essential for identifying and confirming patterns of tobacco product use and for assessing their potential biological effects in both human populations and experimental systems. Due to the introduction of new tobacco-derived products and the development of novel ways to modify and use conventional tobacco products, precise and specific assessments of exposure to tobacco are now more important than ever. Biomarkers that were developed and validated to measure exposure to cigarettes are being evaluated to assess their utility for measuring exposure to these new products...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28522559/pulmonary-toxicity-of-e-cigarettes
#8
Lauren F Chun, Farzad Moazed, Carolyn S Calfee, Michael A Matthay, Jeffrey Earl Gotts
Electronic cigarettes (e-cigarettes or e-cigs) are designed to heat and aerosolize mixtures of vegetable glycerin, propylene glycol, nicotine and flavoring additives, thus delivering nicotine by inhalation in the absence of combustion. These devices were originally developed to facilitate smoking cessation and have been available in the United States for over a decade. Since 2010, e-cig use has expanded rapidly, especially among adolescents, despite a paucity of short and long-term safety data. Patterns of use have shifted to include never-smokers and many dual users of e-cigs and combustible tobacco products...
May 18, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28521275/development-and-validation-of-a-hs-gc-ms-method-for-the-simultaneous-analysis-of-diacetyl-and-acetylpropionyl-in-electronic-cigarette-refills
#9
Sophia Barhdadi, Michaël Canfyn, Patricia Courselle, Vera Rogiers, Tamara Vanhaecke, Eric Deconinck
The use of e-cigarettes as alternative for tobacco cigarettes has become increasingly popular, even though their safety has not yet been scientifically established. One of the frequently raised concerns is the potential toxicity of certain flavours present in the e-liquids, such as diacetyl and acetylpropionyl. It is therefore important to be able to identify and quantify both compounds. Numerous analytical methods have been published for determining e-liquid compositions, but concerns exist with respect to the lack of analytical evaluation...
May 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28520985/warning-statements-and-safety-practices-among-manufacturers-and-distributors-of-electronic-cigarette-liquids-in-the-united-states
#10
Pebbles Fagan, Pallav Pokhrel, Thaddeus A Herzog, Mignonne C Guy, Kari-Lyn K Sakuma, Dennis R Trinidad, Kevin Cassel, Dorothy Jorgensen, Tania Lynch, Jamie Q Felicitas-Perkins, Sherilyn Palafox, Faith Hamamura, Sarah Maloney, Kaylah Degree, Kymberle Sterling, Eric Moolchan, Mark S Clanton, Thomas Eissenberg
Introduction.: Prior to the Food and Drug Administration's (FDA) regulation of electronic cigarettes and warning statements related to nicotine addiction, there was no critical examination of manufacturer/distributor voluntary practices that could potentially inform FDA actions aimed to protect consumers. This study examined the content of warning statements and safety characteristics of electronic cigarette liquid bottles using a national sample. Methods.: Research staff randomly selected four electronic cigarette liquid manufacturers/distributors from four U...
May 18, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28520481/on-the-origins-of-the-electronic-cigarette-british-american-tobacco-s-project-ariel-1962-1967
#11
Stephan Risi
Electronic cigarettes are advertised as the latest technological gadget-the smoking equivalent of smart phones. I challenge this sense of novelty by tracing their history to the 1960s, when researchers at British American Tobacco first recognized that smokers' brains were dependent on nicotine. This discovery enabled British American Tobacco to develop a novel kind of smoking device under the codename "Ariel" between 1962 and 1967. Whereas filters were meant to eliminate specific harmful constituents of tobacco smoke, Project Ariel tried to reduce smoking to its alkaloid essence: nicotine...
May 18, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28515485/e-cigarettes-induce-toxicological-effects-that-can-raise-the-cancer-risk
#12
Donatella Canistro, Fabio Vivarelli, Silvia Cirillo, Clara Babot Marquillas, Annamaria Buschini, Mirca Lazzaretti, Laura Marchi, Vladimiro Cardenia, Maria Teresa Rodriguez-Estrada, Maura Lodovici, Caterina Cipriani, Antonello Lorenzini, Eleonora Croco, Silvia Marchionni, Paola Franchi, Marco Lucarini, Vincenzo Longo, Clara Maria Della Croce, Andrea Vornoli, Annamaria Colacci, Monica Vaccari, Andrea Sapone, Moreno Paolini
Electronic cigarettes (e-cigs) are devices designed to deliver nicotine in a vaping solution rather than smoke and without tobacco combustion. Perceived as a safer alternative to conventional cigarettes, e-cigs are aggressively marketed as lifestyle-choice consumables, thanks to few restrictions and a lack of regulatory guidelines. E-cigs have also gained popularity among never-smokers and teenagers, becoming an emergent public health issue. Despite the burgeoning worldwide consumption of e-cigs, their safety remains largely unproven and it is unknown whether these devices cause in vivo toxicological effects that could contribute to cancer...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28504457/electronic-cigarettes-quit-attempts-and-smoking-cessation-a-6-month-follow-up
#13
Anne Pasquereau, Romain Guignard, Raphaël Andler, Viêt Nguyen-Thanh
BACKGROUND AND AIMS: There is conflicting evidence that use of e-cigarettes promotes cessation in regular smokers, but contrasting findings may be due to differing definitions of vaping. The aim was to assess whether regular use of e-cigarettes while smoking is associated with subsequent smoking cessation. DESIGN: Baseline internet survey with outcomes measured at 6-month follow-up. SETTING: All French metropolitan territory. PARTICIPANTS: 2057 smokers aged 15 to 85 years were recruited through an access panel and responded to a 6-month follow-up: 1805 exclusive tobacco smokers and 252 dual users (tobacco plus regular e-cigarette users) at baseline...
May 14, 2017: Addiction
https://www.readbyqxmd.com/read/28501385/full-and-partial-thickness-burns-from-spontaneous-combustion-of-e-cigarette-lithium-ion-batteries-with-review-of-literature
#14
Daniela Treitl, Rachele Solomon, Dafney L Davare, Rafael Sanchez, Chauniqua Kiffin
BACKGROUND: In recent years, the use of electronic cigarettes (e-cigarettes) has increased worldwide. Most electronic nicotine delivery systems use rechargeable lithium-ion batteries, which are relatively safe, but in rare cases these batteries can spontaneously combust, leading to serious full and partial thickness burn injuries. Explosions from lithium-ion batteries can cause a flash fire and accelerant-related burn injuries. CASE REPORT: A retrospective chart review was conducted of 3 patients with lithium-ion battery burns seen at our Level I community-based trauma center...
May 10, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28496315/hydrogen-coadministration-slows-the-development-of-copd-like-lung-disease-in-a-cigarette-smoke-induced-rat-model
#15
Xiaoyu Liu, Cuiqing Ma, Xiaoyu Wang, Wenjing Wang, Zhu Li, Xiansheng Wang, Pengyu Wang, Wuzhuang Sun, Baojian Xue
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive pulmonary disease caused by harmful gases or particles. Recent studies have shown that 2% hydrogen or hydrogen water is effective in the treatment and prevention of a variety of diseases. This study investigated the beneficial effects and the possible mechanisms of different hydrogen concentrations on COPD. METHODS: A rat COPD model was established through smoke exposure methods, and inhalation of different concentrations of hydrogen was used as the intervention...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28495856/flavored-e-cigarette-liquids-and-cinnamaldehyde-impair-respiratory-innate-immune-cell-function
#16
Phillip Wayne Clapp, Erica Ann Pawlak, Justin Trevor Lackey, James Edward Keating, Steven L Reeber, Gary L Glish, Ilona Jaspers
Innate immune cells of the respiratory tract are the first line of defense against pathogenic and environmental insults. Failure of these cells to perform their immune functions leaves the host susceptible to infection, and may contribute to impaired resolution of inflammation. While combustible tobacco cigarettes have been shown to suppress respiratory immune cell function, the effects of flavored electronic cigarette liquids (e-liquids) and individual flavoring agents on respiratory immune cell responses are unknown...
May 11, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28495220/other-tobacco-product-use-among-sexual-minority-young-adult-bar-patrons
#17
Amanda Fallin-Bennett, Nadra E Lisha, Pamela M Ling
INTRODUCTION: Lesbian, gay, and bisexual (LGB) individuals smoke at rates 1.5-2 times higher than the general population, but less is known about LGB consumption of other tobacco products (OTPs) and gender differences. OTP use among young adult LGB bar patrons and the relationship among past quit attempts, intention to quit, and binge drinking with OTP use was examined. METHODS: A cross-sectional survey of young adults (aged 18-26) in bars/nightclubs in seven U...
May 8, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28482017/evaluation-of-nicotine-pharmacokinetics-and-subjective-effects-following-use-of-a-novel-nicotine-delivery-system
#18
Axel Teichert, Patrick Brossard, Loyse Felber Medlin, Larissa Sandalic, Mikael Franzon, Chris Wynne, Murray Laugesen, Frank Lüdicke
Introduction: Novel nicotine delivery systems represent an evolving part of the tobacco harm reduction strategy. The pharmacokinetic (PK) profile of nicotine delivered by P3L, a pulmonary nicotine delivery system, and its effects on smoking urges and craving relief in relation to Nicorette® inhalator were evaluated. Methods: This open-label, ascending nicotine levels study was conducted in 16 healthy smokers. Three different nicotine delivery levels, 50, 80, and 150 µg/puff delivered by the P3L system were evaluated consecutively on different days, after the use of the Nicorette® inhalator...
May 6, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28481713/internalized-smoking-stigma-in-relation-to-quit-intentions-quit-attempts-and-current-e-cigarette-use
#19
Richard J O'Connor, Vaughan W Rees, Cheryl Rivard, Dorothy K Hatsukami, K Michael Cummings
BACKGROUND: Reducing the social acceptability of smoking is associated with lowered smoking prevalence. However, denormalization strategies can also contribute to the stigmatization that some smokers may feel about their smoking. Smoking stigma may be more acute if smokers are also members of other stigmatized groups, such as racial/ethnic minorities. This study examined correlates of smoking self- and felt-stigma and discrimination, among current smokers. METHODS: Participants were recruited in the United States via a national commercial consumer panel to complete a cross-sectional, web-based survey...
May 8, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28476553/measurement-of-cardiovascular-and-pulmonary-function-endpoints-and-other-physiological-effects-following-partial-or-complete-substitution-of-cigarettes-with-electronic-cigarettes-in-adult-smokers
#20
Carl D D'Ruiz, Grant O'Connell, Donald W Graff, X Sherwin Yan
Acute changes in select physiological parameters associated with cardiovascular physiology (systolic and diastolic blood pressure (BP) and heart rate (HR)), pulmonary function (FVC, FEV1, and exhaled CO and NO) and adverse events were measured in 105 clinically confined subjects who were randomized into groups that either completely or partially switched from conventional cigarettes to e-cigarettes or completely discontinued using tobacco and nicotine products altogether. Use of the e-cigarettes for five days under the various study conditions did not lead to higher BP or HR values, negative respiratory health outcomes or serious adverse health events...
May 3, 2017: Regulatory Toxicology and Pharmacology: RTP
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