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https://www.readbyqxmd.com/read/28931207/study-on-the-effects-of-several-operational-variables-on-the-enzymatic-batch-saccharification-of-orange-solid-waste
#1
Isabel de la Torre, Marianela Ravelo, Silvia Segarra, Marta Tortajada, Victoria E Santos, Miguel Ladero
In this work, batch enzyme-aided extraction and enzymatic saccharification of blade-milled orange waste was studied. The operation variables for this process were thoroughly analysed. It was determined that batch runs with initial pH values of 5.0 and 5.2 controlled during the first hour, 50°C and 300-500r.p.m. agitation resulted in the best yields, with a limited total and partial first-order enzyme deactivation (for cellulases and polygalacturonidase, respectively). Orange peel waste (OPW) at 6.7% w/w dry solid, 0...
August 20, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28931176/the-role-of-cortisol-acth-ratio-for-screening-of-subclinical-hypercortisolism-in-patients-with-adrenal-incidentalomas
#2
Lele Li, Guoqing Yang, Jingtao Dou, Weijun Gu, Zhaohui Lv, Juming Lu, Yiming Mu
Introduction The cortisol/ACTH ratio was supposed to be helpful in the screening of subclinical hypercortisolism (SHC) in the published literatures. This study assessed the cortisol/ACTH ratio in patients with adrenal incidentaloma (AI) confirmed to have SHC and investigated its role for screening SCS in patients with AI. Methods This descriptive retrospective study included 183 patients with AIs [45 with SHC and 138 with non-functional adenoma (NFA)]. Cortisol and ACTH levels were measured at 8:00, 16:00, and 0:00, and the cortisol/ACTH ratio was calculated...
September 20, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28931174/improvement-of-radiological-teaching-effects-of-focusing-of-learning-targets-and-increased-consideration-of-learning-theory-knowledge
#3
Stefan Wirth, York-Alexander William, Marco Paolini, Kathrin Wirth, Daniel Maxien, Maximilian Reiser, Martin R Fischer
Purpose Based on evaluation and examination results of students, a necessity for improvement of so far purely instructor-based radiological teaching at the local institution was determined. Aim of our study was to use one out of eight seminars to exemplify adaptation of the teaching concept according to learning theory knowledge, to determine the resulting effects and to interpret them. Materials and methods The institutional review board approved the prospective study of the seminar conversion, which was performed after the end of the winter semester 2015/2016...
September 20, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28931080/low-serum-level-of-mir-485-3p-predicts-poor-survival-in-patients-with-glioblastoma
#4
Zhi-Qiang Wang, Mei-Yin Zhang, Mei-Ling Deng, Nuo-Qing Weng, Hui-Yun Wang, Shao-Xiong Wu
MicroRNAs (miRNAs) are short noncoding RNAs that play critical roles in human malignancies and can be used as biomarkers for cancer. Until now, a number of biomarkers for prognosis of glioblastoma (GBM) have been reported in tumor tissues but only a few biomarkers in circulating fluid. Using a custom microarray, we previously identified 19 differentially expressed miRNAs in serum of patients with GBM. In this study, we investigated whether 3 of the 19 miRNAs in serum could be used as prognostic biomarkers for patients with GBM...
2017: PloS One
https://www.readbyqxmd.com/read/28931046/clinical-relevance-of-histologic-subtypes-in-locally-advanced-esophageal-carcinoma-treated-with-pre-operative-chemoradiotherapy-experience-of-a-monographic-oncologic-centre
#5
Maria Saigí, Marc Oliva, Luisa Aliste, Mariona Calvo, Gloria Hormigo, Òlbia Serra, Anna Boladeras, Leandre Farran, Javier Robles, Gloria Creus, Ma José Paúles, Joan B Gornals, Eugenia de Lama, Josep Ma Borràs, Núria Sala, Maica Galán
BACKGROUND: Locally advanced esophageal carcinoma (LAEC) represents less than 30% of all diagnosed esophageal carcinoma worldwide. The standard of care for resectable tumours consists of preoperative chemoradiotherapy (CRT) followed by surgery. Despite the curative intent, the prognosis is still poor mainly due to relapse. A multidisciplinary approach is required in order to optimize the therapeutic strategy and follow-up. Differences in outcomes between the two main histological subtypes, adenocarcinoma (ADC) and squamous cell carcinoma (SCC), have been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28931025/the-clinical-and-microbiological-characteristics-of-enteric-fever-in-cambodia-2008-2015
#6
Laura M F Kuijpers, Thong Phe, Chhun H Veng, Kruy Lim, Sovann Ieng, Chun Kham, Nizar Fawal, Laetitia Fabre, Simon Le Hello, Erika Vlieghe, François-Xavier Weill, Jan Jacobs, Willy E Peetermans
BACKGROUND: Enteric fever remains a major public health problem in low resource settings and antibiotic resistance is increasing. In Asia, an increasing proportion of infections is caused by Salmonella enterica serovar Paratyphi A, which for a long time was assumed to cause a milder clinical syndrome compared to Salmonella enterica serovar Typhi. METHODOLOGY: A retrospective chart review study was conducted of 254 unique cases of blood culture confirmed enteric fever who presented at a referral adult hospital in Phnom Penh, Cambodia between 2008 and 2015...
September 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28930955/comparison-of-compensatory-reserve-and-arterial-lactate-as-markers-of-shock-and-resuscitation
#7
Michael Craig Johnson, Abdul Alarhayem, Victor Convertino, Robert Carter, Kevin Chung, Ronald Stewart, John Myers, Daniel Dent, Lilian Liao, Ramon Cestero, Susannah Nicholson, Mark Muir, Martin Schwaca, David Wampler, Mark DeRosa, Brian J Eastridge
BACKGROUND: During traumatic hemorrhage, the ability to identify shock and intervene before decompensation is paramount to survival. Lactate is extremely sensitive to shock, and its clearance has been demonstrated a useful gauge of shock and resuscitation status. Though lactate can be measured in the field, logistical constraints render it impractical in certain environments. The compensatory reserve represents a new clinical measurement reflecting the remaining capacity to compensate for hypoperfusion...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930850/evaluation-of-acute-normovolemic-hemodilution-in-patients-undergoing-intracranial-meningioma-resection-a-quasi-experimental-trial
#8
Lei Yang, Hui-Hui Wang, Fu-Sheng Wei, Long-Xian Ma
The aim of this study was to evaluate the safety of acute normovolemic hemodilution (ANH) for patients undergoing intracranial meningioma resection.Eighty patients (aged 48-65 years) with American Society of Anesthesiologists physical status I-II undergoing intracranial meningioma resection were included in this prospective observational study. The patients were randomly divided into group A (ANH group), which underwent a combination of ANH and intraoperative cell salvage (ICS), and group B (control group), which underwent ICS alone...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930844/health-related-quality-of-life-assessment-in-surgical-patients-with-papillary-thyroid-carcinoma-a-single-center-analysis-from-mainland-china
#9
Juxiang Gou, Wenjie Cheng, Jianyong Lei, Qian Pan, Wei You, Ming Cai, Huairong Tang, Yali Lei, Zhihui Li, Rixiang Gong, Jinqiang Zhu
Even with a favorable prognosis, the health-related quality of life (HRQoL) of papillary thyroid carcinoma (PTC) patients remains unclear and conflicting. Thus, in the present study, we compared the HRQoL of PTC patients with that of the general population (GP).The study was performed in our thyroid and parathyroid surgery department, and 186 PTC patients who had undergone thyroidectomy were included. The exclusion criteria were an age < 18 years, no follow-up, and the presence of other malignant neoplasms...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930841/totally-laparoscopic-versus-open-total-gastrectomy-for-gastric-cancer-a-case-matched-study-about-short-term-outcomes
#10
Ke Chen, Yu Pan, Shu-Ting Zhai, Wei-Hua Yu, Jun-Hai Pan, Yi-Ping Zhu, Qi-Long Chen, Xian-Fa Wang
Although surgical outcomes of totally laparoscopic total gastrectomy (TLTG) have been reported from several centers, the effectiveness of this technique has not been conclusively established. The aim of this study was to investigate the feasibility, safety, and efficacy of TLTG for gastric cancer.A prospectively collected and retrospectively analyzed data were used by comparing the short-term surgical outcomes of 124 patients who underwent TLTG with those of 124 patients who underwent open total gastrectomy (OTG) between March 2007 and March 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930837/the-prognostic-value-of-shock-index-for-the-outcomes-of-acute-myocardial-infarction-patients-a-systematic-review-and-meta-analysis
#11
Xiaocong Zhang, Zejie Wang, Zhenyu Wang, Manling Fang, Zhouwu Shu
BACKGROUND: Several studies have revealed that high shock index (SI) is a risk factor for acute myocardial infarction (AMI) patients. These studies do not give a systematic review in this issue. Therefore, we conducted a systematic review and meta-analysis to determine the effect of high SI on the prognosis of AMI patients. METHODS: We did a systematic search of PubMed, Embase, and the Cochrane Library, using various combinations of keywords such as "shock index," "shock-index," "acute myocardial infarction," "ST elevation myocardial infarction," "non-ST segment elevation myocardial infarction," "STEMI," "NSTEMI," "AMI," and "MI" for eligible studies published up to December 23, 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930835/the-effects-of-hemolysis-on-plasma-prothrombin-time-and-activated-partial-thromboplastin-time-tests-using-photo-optical-method
#12
Yetti Hernaningsih, Jeine Stela Akualing
Hemolysis is the most common reason why coagulation test samples are rejected. However, the effects of hemolysis on plasma prothrombin time (PPT) and activated partial thromboplastin time (APTT) are rarely investigated and the results are controversial. This research aims to analyze the effects of hemolysis on PPT and APPT using the photo-optical method.Nonhemolyzed citrate blood samples (n = 30) with normal PPT and APTT underwent 2-step mechanical lysis and then hemoglobin level measurement was carried out at each step...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930832/early-central-and-peripheral-corneal-microstructural-changes-in-type-2-diabetes-mellitus-patients-identified-using-in-vivo-confocal-microscopy-a-case-control-study
#13
Jing-Hao Qu, Lei Tian, Xiao-Yu Zhang, Xu-Guang Sun
The aim of this study was to find early central and peripheral corneal microstructural changes in healthy subjects and type 2 diabetes mellitus (T2DM) patients with/without cornea fluorescein dot staining.This is a prospective case-control study of T2DM patients with/without cornea fluorescein dot staining. Age, sex, duration of diabetes, and serum glycosylated hemoglobin A1c (HbA1c) levels were recorded. Keratograph 5 M (K5 M) and in vivo confocal microscopy were performed on all subjects. The cornea was divided into 5 zones: central, superior, temporal, nasal, and inferior...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930828/18f-fdg-pet-ct-in-preoperative-staging-of-vulvar-cancer-patients-is-it-really-effective
#14
Cinzia Crivellaro, Priscilla Guglielmo, Elena De Ponti, Federica Elisei, Luca Guerra, Sonia Magni, Maria La Manna, Giampaolo Di Martino, Claudio Landoni, Alessandro Buda
The aim of this study was to assess the role of 18F-FDG PET/CT in preoperative staging of vulvar cancer patients.29 pts (69 years, range 51-88) with vulvar cancer (clinical apparent stage I-II), underwent preoperative FDG-PET/CT scan followed by radical vulvectomy and bilateral (or monolateral in case of tumor >2 cm from midline) inguinal lymphadenectomy ± sentinel node biopsy. PET/CT images were analyzed in consensus and correlated to histological findings according to a pt-based and a groin-based analyses...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930824/evaluating-the-morphology-of-the-left-atrial-appendage-by-a-transesophageal-echocardiographic-3-dimensional-printed-model
#15
Hongning Song, Qing Zhou, Lan Zhang, Qing Deng, Yijia Wang, Bo Hu, Tuantuan Tan, Jinling Chen, Yiteng Pan, Fazhi He
The novel 3-dimensional printing (3DP) technique has shown its ability to assist personalized cardiac intervention therapy. This study aimed to determine the feasibility of 3D-printed left atrial appendage (LAA) models based on 3D transesophageal echocardiography (3D TEE) data and their application value in treating LAA occlusions.Eighteen patients with transcatheter LAA occlusion, and preprocedure 3D TEE and cardiac computed tomography were enrolled. 3D TEE volumetric data of the LAA were acquired and postprocessed for 3DP...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930815/variability-in-usual-care-mechanical-ventilation-for-pediatric-acute-respiratory-distress-syndrome-time-for-a-decision-support-protocol
#16
Christopher J L Newth, Katherine A Sward, Robinder G Khemani, Kent Page, Kathleen L Meert, Joseph A Carcillo, Thomas P Shanley, Frank W Moler, Murray M Pollack, Heidi J Dalton, David L Wessel, John T Berger, Robert A Berg, Rick E Harrison, Richard Holubkov, Allan Doctor, J Michael Dean, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: Although pediatric intensivists philosophically embrace lung protective ventilation for acute lung injury and acute respiratory distress syndrome, we hypothesized that ventilator management varies. We assessed ventilator management by evaluating changes to ventilator settings in response to blood gases, pulse oximetry, or end-tidal CO2. We also assessed the potential impact that a pediatric mechanical ventilation protocol adapted from National Heart Lung and Blood Institute acute respiratory distress syndrome network protocols could have on reducing variability by comparing actual changes in ventilator settings to those recommended by the protocol...
September 19, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28930805/the-value-of-diffusion-weighted-imaging-in-combination-with-conventional-magnetic-resonance-imaging-for-improving-tumor-detection-for-early-cervical-carcinoma-treated-with-fertility-sparing-surgery
#17
Xiulei Li, Ling Wang, Yong Li, Peiji Song
OBJECTIVE: This study aimed to investigate the value of diffusion-weighted imaging (DWI) in combination with conventional magnetic resonance imaging (MRI) for improving tumor detection in young patients treated with fertility-sparing surgery because of early cervical carcinoma. METHODS: Fifty-four patients with stage Ia or Ib1 cervical carcinoma were enrolled into this study. Magnetic resonance examinations were performed for these patients using conventional MRI (including T1-weighted imaging, T2-weighted imaging, and dynamic contrast-enhanced MRI) and DWI...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28930760/medical-education-and-health-care-delivery-a-call-to-better-align-goals-and-purposes
#18
David P Sklar, Paul A Hemmer, Steven J Durning
The transformation of the U.S. health care system is under way, driven by the needs of an aging population, rising health care spending, and the availability of health information. However, the speed and effectiveness of the transformation of health care delivery will depend, in large part, upon engagement of the health professions community and changes in clinicians' practice behaviors. Current efforts to influence practice behaviors emphasize changes in the health payment system with incentives to move from fee-for-service to alternative payment models...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930715/cigarette-smoking-attenuates-kidney-protection-by-angiotensin-converting-enzyme-inhibition-in-nondiabetic-chronic-kidney-disease
#19
Bethany Roehm, Jan Simoni, Jessica Pruszynski, Donald E Wesson
BACKGROUND: Cigarette smoking exacerbates the estimated glomerular filtration rate (eGFR) decline in nondiabetic chronic kidney disease (CKD) despite the kidney protection that is achieved by angiotensin converting enzyme inhibition (ACEI). Whether smoking cessation restores ACEI-related kidney protection is not known. METHODS: This 5-year, prospective, prevention trial recruited 108 smokers and 108 nonsmokers with stage-2 nondiabetic CKD with primary hypertension and urine albumin-to-creatinine ratio (Ualb) >200 mg/g...
September 21, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28930371/polyhydramnios-frequency-of-congenital-anomalies-in-relation-to-the-value-of-the-amniotic-fluid-index
#20
Jakub Kornacki, Magdalena Adamczyk, Przemysław Wirstlein, Maciej Osiński, Ewa Wender-Ożegowska
OBJECTIVES: The aims of our study were to assess the correlation between the amniotic fluid index (AFI) value and the frequency and type of fetal anomalies. MATERIAL AND METHODS: The material included 94 patients at the third trimester of pregnancy, 60 with mild polyhydramnios, 19 with moderate one, and 15 with severe one. Polyhydramnios was diagnosed if AFI was > 24 cm. All patients were divided into three groups based on the value of AFI: 1) mild polyhydramnios with AFI between 24...
2017: Ginekologia Polska
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