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https://www.readbyqxmd.com/read/29353454/acute-phase-plasma-osteopontin-as-an-independent-predictor-for-poor-outcome-after-aneurysmal-subarachnoid-hemorrhage
#1
Yoshinari Nakatsuka, Masato Shiba, Hirofumi Nishikawa, Mio Terashima, Fumihiro Kawakita, Masashi Fujimoto, Hidenori Suzuki
Experimental studies reported that osteopontin (OPN), a matricellular protein, is induced in brain after subarachnoid hemorrhage (SAH). The aim of this study was to investigate the relationships between plasma OPN levels and outcome after aneurysmal SAH in a clinical setting. This is a prospective study consisting of 109 aneurysmal SAH patients who underwent aneurysmal obliteration within 48 h of SAH. Plasma OPN concentrations were serially determined at days 1-3, 4-6, 7-9, and 10-12 after onset. Various clinical factors as well as OPN values were compared between patients with 90-day good and poor outcomes...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29353434/prediction-of-progression-in-skull-base-meningiomas-additional-benefits-of-apparent-diffusion-coefficient-value
#2
Ching-Chung Ko, Sher-Wei Lim, Tai-Yuan Chen, Jeon-Hor Chen, Chien-Feng Li, Yow-Ling Shiue
A subset of benign (WHO grade I) skull base meningiomas show early progression/recurrence (P/R) in the first years after surgical resection. Besides, complete surgical resection may be difficult to achieve safely in skull base meningiomas due to complex neurovascular structures. The one main challenge in the treatment of skull base meningiomas is to determine factors that correlate with P/R. We retrospectively investigated the preoperative CT and MR imaging features for the prediction of P/R in skull base meningiomas, with emphasis on quantitative ADC values...
January 20, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29353425/natural-attenuation-of-petroleum-hydrocarbons-a-study-of-biodegradation-effects-in-groundwater-vitanovac-serbia
#3
Nenad Marić, Ivan Matić, Petar Papić, Vladimir P Beškoski, Mila Ilić, Gordana Gojgić-Cvijović, Srđan Miletić, Zoran Nikić, Miroslav M Vrvić
The role of natural attenuation processes in groundwater contamination by petroleum hydrocarbons is of intense scientific and practical interest. This study provides insight into the biodegradation effects in groundwater at a site contaminated by kerosene (jet fuel) in 1993 (Vitanovac, Serbia). Total petroleum hydrocarbons (TPH), hydrochemical indicators (O2, NO3-, Mn, Fe, SO42-, HCO3-), δ13C of dissolved inorganic carbon (DIC), and other parameters were measured to demonstrate biodegradation effects in groundwater at the contaminated site...
January 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29353420/properties-of-antibiotic-resistant-bacteria-isolated-from-onsite-wastewater-treatment-plant-in-relation-to-biofilm-formation
#4
Łukasz Jałowiecki, Joanna Żur, Joanna Chojniak, Helene Ejhed, Grażyna Płaza
The aim of the present study was to determine some properties of antibiotic-resistant bacterial strains isolated from onsite wastewater technology in relation to biofilm formation, e.g., autoaggregation and motility. Additionally, biosurfactant production by the isolates was also evaluated. The ability of selected strains to develop a biofilm was assessed by using the crystal violet method, which allows to indirectly quantify the attached bacterial biomass (live, dead cells, and polysaccharides as well). Obtained results showed that 19 of the analyzed strains were able to produce biofilm after 72 h of incubation...
January 20, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29353417/maternal-metabolic-response-to-dietary-treatment-for-impaired-glucose-tolerance-and-gestational-diabetes-mellitus
#5
Karen L Lindsay, Lorraine Brennan, Maria A Kennelly, Sinéad Curran, Mary Coffey, Thomas P Smith, Michael E Foley, Mensud Hatunic, Fionnuala M McAuliffe
BACKGROUND: Dietary advice is a standard component of treatment for pregnant women with impaired glucose tolerance (IGT) and gestational diabetes (GDM), yet few studies report glycemic profiles in response to dietary therapies and the optimal dietary approach remains uncertain. AIM: To assess changes in maternal glycemic profile and pregnancy outcomes among women with diet-controlled IGT and GDM. METHODS: Pregnant women who had one or more elevated values on a 3-h oral glucose tolerance test were enrolled...
January 20, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29353377/highly-synergistic-activity-of-melittin-with-imipenem-and-colistin-in-biofilm-inhibition-against-multidrug-resistant-strong-biofilm-producer-strains-of-acinetobacter-baumannii
#6
Ali Mohammadi Bardbari, Mohammad Reza Arabestani, Manoochehr Karami, Fariba Keramat, Hossein Aghazadeh, Mohammad Yousef Alikhani, Kamran Pooshang Bagheri
The rapid increase of drug resistance and failure of available antibiotics to treat biofilm-associated infections is of great health concern. Accordingly, our study aimed to evaluate the synergistic antibacterial, biofilm inhibitory, and biofilm removal activities of melittin in combination with colistin, imipenem, and ciprofloxacin against multidrug-resistant (MDR) strong biofilm producer Acinetobacter baumannii isolates. The kinetics of biofilm formation were evaluated for the isolates for 144 h. Minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs), minimum biofilm inhibitory concentrations (MBICs), and biofilm removal activities for melittin and combinations with antibiotics were determined...
January 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29353328/serum-uric-acid-levels-are-associated-with-lupus-nephritis-in-patients-with-normal-renal-function
#7
Ana Luisa Calich, Eduardo Ferreira Borba, Michelle Remião Ugolini-Lopes, Luiza Fuoco da Rocha, Eloisa Bonfá, Ricardo Fuller
Uric acid has been recognised as a potential marker of endothelial dysfunction and kidney disease but there are scarce data about its importance in systemic lupus erythematosus (SLE) nephritis. This study aimed to evaluate serum uric acid (UA) levels in lupus nephritis (LN), by comparing SLE patients with normal renal function, with and without nephritis. Forty-six female SLE patients were consecutively selected and divided in two groups according to renal activity at the evaluation: presence of a recently diagnosed lupus nephritis (LN+, n = 18) and absence of lupus nephritis (LN-, n = 28)...
January 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29353326/radiological-and-functional-outcomes-of-high-grade-spondylolisthesis-treated-by-intrasacral-fixation-dome-resection-and-circumferential-fusion-a-retrospective-series-of-20-consecutive-cases-with-a-minimum-of-2%C3%A2-years-follow-up
#8
E Ferrero, B Ilharreborde, V Mas, C Vidal, A-L Simon, K Mazda
PURPOSE: Major concern during surgery for high-grade spondylolisthesis (HGS) is to reduce lumbosacral kyphosis and restore sagittal alignment. Despite the numerous methods described, lumbosacral fixation in HGS is a challenging technique associated with high complication rate. Few series have described outcomes and most of the results are limited to lumbosacral correction without global sagittal alignment analysis. This study aims at analyzing clinical and radiological outcomes of HGS patients treated with intrasacral rods on full spine radiographs...
January 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29353318/diagnostic-value-of-vascular-endothelial-growth-factor-transforming-growth-factor-%C3%AE-interleukin-8-and-the-ratio-of-lactate-dehydrogenase-to-adenosine-deaminase-in-pleural-effusion
#9
Takeshi Saraya, Kosuke Ohkuma, Takayasu Watanabe, Sunao Mikura, Fumi Kobayashi, Junpei Aso, Hiroki Nunokawa, Kojiro Honda, Yukari Ogawa, Masaki Tamura, Mitsuru Sada, Miku Oda, Manami Inoue, Takuma Yokoyama, Daisuke Kurai, Haruyuki Ishii, Hirokazu Kimura, Hajime Takizawa
PURPOSE: We studied the diagnostic value of cytokines, including vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and interleukin-8 (IL-8), and the ratio of lactate dehydrogenase (LDH) to adenosine deaminase (ADA) in pleural fluid. METHODS: Prospective analysis of 44 inpatients or outpatients with pleural fluid, from December 2016 to March 2017 was conducted. RESULTS: We enrolled patients with malignant pleural effusion (MPE, N = 15), empyema (N = 11), parapneumonic effusion (PPE, N = 7), chronic renal failure (CRF)/chronic heart failure (CHF) (N = 7), and tuberculous pleural effusion (TBPE, N = 4)...
January 20, 2018: Lung
https://www.readbyqxmd.com/read/29353299/creation-of-the-txp-parenting-questionnaire-and-study-of-its-psychometric-properties
#10
Ana Benito, Gema Calvo, Matías Real-López, María José Gallego, Sonia Francés, Ángel Turbi, Gonzalo Haro
Parenting is linked to conduct disorders (CD) and substance related disorders (SRD) in adolescents, but with differences according to cultural context. A questionnaire with two versions (parenting questionnaire TXP-A for adolescents and TXP-C  for primary caregivers) was designed using the Delphi method to evaluate parenting practices related to CD and SRD in a Spanish population. It was validated in a community sample of 631 adolescents aged between 14 and 16 and their caregivers. Results suggest a 29-item TXP-A questionnaire with bifactorial structure: affection-communication and control-structure, with high internal (Cronbach’s alpha=0...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29353280/microstructure-of-strategic-white-matter-tracts-and-cognition-in-memory-clinic-patients-with-vascular-brain-injury
#11
J Matthijs Biesbroek, Alexander Leemans, Hanna den Bakker, Marco Duering, Benno Gesierich, Huiberdina L Koek, Esther van den Berg, Albert Postma, Geert Jan Biessels
BACKGROUND: White matter injury is an important factor for cognitive impairment in memory clinic patients. We determined the added value of diffusion tensor imaging (DTI) of strategic white matter tracts in explaining variance in cognition in memory clinic patients with vascular brain injury. METHODS: We included 159 patients. Conventional MRI markers (white matter hyperintensity volume, lacunes, nonlacunar infarcts, brain atrophy, and microbleeds), and fractional anisotropy and mean diffusivity (MD) of the whole brain white matter and of 18 white matter tracts were related to cognition using linear regression and Bayesian network analysis...
January 19, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29353278/stereoselective-inhibition-of-renal-basolateral-human-organic-anion-transporter-3-by-lansoprazole-enantiomers
#12
Yugo Hamada, Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda
Lansoprazole, a proton pump inhibitor, potently inhibits human organic anion transporter, hOAT3 (SLC22A8). Lansoprazole has an asymmetric atom in its structure and is clinically administered as a racemic mixture of (R)-and (S)-enantiomers. However, little is known about the stereoselective inhibitory potencies of lansoprazole against hOAT3 and its homolog, hOAT1. In the present study, the stereoselective inhibitory effect of lansoprazole was evaluated using hOAT1-and hOAT3-expressing cultured cells. hOAT1 and hOAT3 transported [14C]p-aminohippurate and [3H]estrone-3-sulfate (ES) with Michaelis-Menten constants of 29...
January 19, 2018: Pharmacology
https://www.readbyqxmd.com/read/29353261/impact-of-delivered-tidal-volume-on-the-occurrence-of-intraventricular-haemorrhage-in-preterm-infants-during-positive-pressure-ventilation-in-the-delivery-room
#13
Qaasim Mian, Po-Yin Cheung, Megan O'Reilly, Samantha K Barton, Graeme R Polglase, Georg M Schmölzer
BACKGROUND AND OBJECTIVES: Delivery of inadvertent high tidal volume (VT) during positive pressure ventilation (PPV) in the delivery room is common. High VT delivery during PPV has been associated with haemodynamic brain injury in animal models. We examined if VT delivery during PPV at birth is associated with brain injury in preterm infants <29 weeks' gestation. METHODS: A flow-sensor was placed between the mask and the ventilation device. VT values were compared with recently described reference ranges for VT in spontaneously breathing preterm infants at birth...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353214/effects-of-poor-sleep-quality-on-brain-functional-connectivity-revealed-by-wavelet-based-coherence-analysis-using-nirs-methods-in-elderly-subjects
#14
Lingguo Bu, Dawei Wang, Congcong Huo, Gongcheng Xu, Zengyong Li, Jianfeng Li
OBJECTIVE: Poor sleep quality, which is typically related to impairments in cognitive control, is pervasive among the elderly. However, the brain function mechanisms underlying the association between sleep and elderly behavior remain elusive. This study aims to assess the effects of poor sleep quality on low-frequency neural oscillations based on the wavelet phase coherence (WPCO) and wavelet amplitude (WA) of oxyhemoglobin concentration changes (Delta [HbO2]) measured through near-infrared spectroscopy (NIRS) method...
January 17, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29353187/medication-use-in-a-cohort-of-newly-admitted-nursing-home-residents-ageing-nh-in-relation-to-evolving-physical-and-mental-health
#15
Ivana Ivanova, Maarten Wauters, Robert Vander Stichele, Thierry Christiaens, Jonas De Wolf, Tine Dilles, Monique Elseviers
BACKGROUND: Medication use is high among nursing home (NH) residents, but there is a lack of longitudinal studies, determining medication use at admission and its evolution over time. AIM: Describing the evolution of the medication use two years after entering a NH, compared to the baseline observations and exploring the relation to the physical and mental health. METHODS: Data from the observational prospective Ageing@NH study, based on an inception cohort of newly admitted residents at NHs (65+) was used, selecting those consenting and with medication chart available...
January 17, 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29353130/serum-mir-1181-and-mir-4314-associated-with-ovarian-cancer-mirna-microarray-data-analysis-for-a-pilot-study
#16
Lihong Ruan, Yuanyuan Xie, Fangmei Liu, Xuehua Chen
OBJECTIVE: This study aims to identify serum microRNAs (miRNAs) related to ovarian cancer. STUDY DESIGN: MiRNA profiling data (GSE79943) were generated from the Gene Expression Omnibus, including 3 serum samples from healthy individuals and 4/3/16/6 serum samples from patients with ovarian cancer stage I/II/III/IV. Differentially expressed miRNAs (DEmiRNAs) were identified between controls and ovarian cancer stage I/II/III/IV by using limma package (p-value <0...
January 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29353124/projecting-environmental-suitable-areas-for-malaria-transmission-in-china-under-climate-change-scenarios
#17
Samuel Hundessa, Shanshan Li, De Li Liu, Jinpeng Guo, Yuming Guo, Wenyi Zhang, Gail Williams
INTRODUCTION: The proportion of imported malaria cases in China has increased over recent years, and has presented challenges for the malaria elimination program in China. However, little is known about the geographic distribution and environmental suitability for malaria transmission under projected climate change scenarios. METHODS: Using the MaxEnt model based on malaria presence-only records, we produced environmental suitability maps and examined the relative contribution of topographic, demographic, and environmental risk factors for P...
January 17, 2018: Environmental Research
https://www.readbyqxmd.com/read/29353074/diagnostic-value-of-human-papillomavirus-hpv-16-and-hpv18-viral-loads-for-the-detection-of-high-grade-cervical-intraepithelial-neoplasia-cin2-in-a-cohort-of-african-women-living-with-hiv
#18
Michel Segondy, Jean Ngou, Helen Kelly, Tanvier Omar, Olga Goumbri-Lompo, Sylviane Doutre, Philippe Mayaud, Marie-Noelle Didelot
BACKGROUND: African women living with HIV (WLHIV) are at high risk of cervical cancer but rarely adequately screened. Better strategies enabling identification of WLHIV with high-grade cervical intraepithelial lesions (CIN2+) are required. OBJECTIVES: To investigate the diagnostic value of HPV16 and HPV18 viral loads in a cohort of African WLHIV. DESIGN: HPV16 and HPV18 viral loads were determined by quantitation of the E6 gene DNA by real-time PCR in cervical specimens collected at baseline and endline (16 months) from 245 African WLHIV positive for HPV16 or/and HPV18...
January 16, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29352853/interferon-regulatory-factor-5-is-a-potential-target-of-autoimmune-response-triggered-by-epstein-barr-virus-and-mycobacterium-avium-subsp-paratuberculosis-in-rheumatoid-arthritis-investigating-a-mechanism-of-molecular-mimicry
#19
Marco Bo, Gian Luca Erre, Magdalena Niegowska, Marco Piras, Loredana Taras, Maria Giovanna Longu, Giuseppe Passiu, Leonardo A Sechi
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic disease characterised by a pro-inflammatory cytokines linked erosive joint damage and by humoral and cellular response against a broad range of self-peptides. Molecular mimicry between Epstein-Barr virus (EBV), Mycobacterium avium subsp. paratuberculosis (MAP) and host peptides has long been regarded as an RA pathogenetic mechanism. Using bioinformatic analysis we identified high sequence homology among interferon regulatory factor 5 (IRF5), EBV antigen BOLF1 and MAP antigen MAP_4027...
January 15, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29352841/predict-rheumatoid-arthritis-conversion-from-undifferentiated-arthritis-with-dynamic-contrast-enhanced-mri-and-laboratory-indexes
#20
Xinwei Lei, Huixia Li, Ying Zhan, Jin Qu
OBJECTIVES: To investigate the clinical value of dynamic contrast-enhanced MRI (DCE-MRI) and laboratory indexes in predicting conversion from undifferentiated arthritis (UA) to rheumatoid arthritis (RA). METHODS: A total 81 DMARD-naive UA patients were studied. 37 cases were ultimately diagnosed as RA, 32 cases were diagnosed as other types of arthritis, and the remaining cases were still UA during the 1-year follow-up. The DCE-MRI and laboratory measures were fed into a logistic regression analysis...
January 15, 2018: Clinical and Experimental Rheumatology
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