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Cristina Pistea, Evelyne Lonsdorfer, Stéphane Doutreleau, Monique Oswald, Irina Enache, Anne Charloux
We evaluated the impact of selection of reference values on the categorisation of measured maximal oxygen consumption (V'O2peak) as "normal" or "abnormal" in an ageing population. We compared measured V'O2peak with predicted values and the lower limit of normal (LLN) calculated with five equations. 99 (58 males and 41 females) disease-free subjects aged ≥70 years completed an incremental maximal exercise test on a cycle ergometer. Mean V'O2peak was 1.88 L·min(-1) in men and 1.26 L·min(-1) in women...
January 2016: ERJ Open Research
Yasuhiko Kubota, Stephanie J London, Mary Cushman, Alanna M Chamberlain, Wayne D Rosamond, Susan R Heckbert, Neil Zakai, Aaron R Folsom
BACKGROUND: The evidence of the association between chronic obstructive pulmonary disease (COPD) and venous thromboembolism (VTE) is limited. There is no study investigating the association of restrictive lung disease (RLD) and respiratory symptoms with VTE. OBJECTIVES: To investigate prospectively the association of lung function and respiratory symptoms with VTE. PATIENTS/METHODS: In 1987-1989, we assessed lung function using spirometry and obtained information on respiratory symptoms (cough, phlegm and dyspnea) in 14 654 participants aged 45-64, without a history of VTE or anticoagulant use, and followed them through 2,011...
October 1, 2016: Journal of Thrombosis and Haemostasis: JTH
Tjard R Schermer, Bas Robberts, Alan J Crockett, Bart P Thoonen, Annelies Lucas, Joke Grootens, Ivo J Smeele, Cindy Thamrin, Helen K Reddel
Clinical guidelines indicate that a chronic obstructive pulmonary disease (COPD) diagnosis is made from a single spirometry test. However, long-term stability of diagnosis based on forced expiratory volume in 1 s over forced vital capacity (FEV1/FVC) ratio has not been reported. In primary care subjects at risk for COPD, we investigated shifts in diagnostic category (obstructed/non-obstructed). The data were from symptomatic 40+ years (ex-)smokers referred for diagnostic spirometry, with three spirometry tests, each 12±2 months apart...
September 29, 2016: NPJ Primary Care Respiratory Medicine
André F S Amaral, David P Strachan, Francisco Gómez Real, Peter G J Burney, Deborah L Jarvis
Little is known about the effect of cessation of menstruation on lung function. The aims of the study were to examine the association of lung function with natural and surgical cessation of menstruation, and assess whether lower lung function is associated with earlier age at cessation of menstruation.The study was performed in 141 076 women from the UK Biobank, who had provided acceptable and reproducible spirometry measurements and information on menstrual status. The associations of lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), spirometric restriction (FVC < lower limit of normal (LLN)), airflow obstruction (FEV1/FVC <LLN)) with cessation of menstruation and age at cessation of menstruation were assessed using regression analysis...
September 22, 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Rana R McKay, Susanna Jacobus, Matthew Fiorillo, Elisa M Ledet, Patrick M Cotogna, Allie E Steinberger, Heather A Jacene, Oliver Sartor, Mary-Ellen Taplin
BACKGROUND: Radium-223 has shown clinical efficacy in metastatic castration-resistant prostate cancer. Despite improvement in quality of life and survival, practice patterns and utility of this agent outside the context of clinical trials have not been fully characterized. The primary objective in this study was to evaluate variables associated with completion of 5 to 6 radium-223 doses. PATIENTS AND METHODS: We conducted retrospective analyses of patients who received radium-223 (n = 135)...
August 20, 2016: Clinical Genitourinary Cancer
Stefan Karrasch, Irene Brüske, Maia P Smith, Barbara Thorand, Cornelia Huth, Karl-Heinz Ladwig, Florian Kronenberg, Joachim Heinrich, Rolf Holle, Annette Peters, Holger Schulz
BACKGROUND: There is an ongoing debate about the appropriate spirometric criterion for airway obstruction to detect COPD. Furthermore, the association of different criteria with comorbidity prevalence and inflammatory biomarkers in advanced age is unclear. MATERIALS AND METHODS: Spirometry was performed in a population-based study (n=2,256) covering an age range of 41-90 years. COPD was spirometrically determined either by a fixed ratio (FR) of <0.7 for forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) or by FEV1/FVC below the lower limit of normal (LLN)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Girum Ketema Teklemariam, Floris Van Den Abeele, Ingrid Moerman, Piet Demeester, Jeroen Hoebeke
Sensors and actuators are becoming important components of Internet of Things (IoT) applications. Today, several approaches exist to facilitate communication of sensors and actuators in IoT applications. Most communications go through often proprietary gateways requiring availability of the gateway for each and every interaction between sensors and actuators. Sometimes, the gateway does some processing of the sensor data before triggering actuators. Other approaches put this processing logic further in the cloud...
2016: Sensors
Stefan P Wesolowski, Piotr W Boros, Tadeusz M Orłowski, Philip H Quanjer
BACKGROUND: Impaired lung function (LF) is a well-known risk factor for perioperative complications in patients qualified for lung resection surgery. The recent European guidelines recommend using values below 80% predicted as indicating abnormal LF rather than the lower limit of normal (LLN). OBJECTIVES: To assess how the choice of a cut-off point (80% predicted vs. LLN at -1.645 SD) affects the incidence of functional disorders and postoperative complications in lung cancer patients referred for lung resection...
2016: Respiration; International Review of Thoracic Diseases
Daniel M Green, Liang Zhu, Mingjuan Wang, Kirsten K Ness, Matthew J Krasin, Nickhill H Bhakta, M Beth McCarville, Saumini Srinivasan, Dennis C Stokes, DeoKumar Srivastava, Rohit Ojha, Kyla Shelton, Ching-Hon Pui, Gregory T Armstrong, Daniel A Mulrooney, Monika Metzger, Sheri L Spunt, Fariba Navid, Andrew M Davidoff, Bhaskar N Rao, Leslie L Robison, Melissa M Hudson
RATIONALE: The relationship between treatment-related impairment of pulmonary function in adult survivors of childhood cancer and subsequent physical function has not been studied. OBJECTIVES: In this prospective evaluation of 606 adult survivors of childhood cancer, we sought to determine the risk factors for, as well as the functional impact of, clinically ascertained pulmonary function impairment. METHODS: We measured FEV1, FVC, total lung capacity (TLC), and single-breath diffusing capacity of the lung for carbon monoxide corrected for hemoglobin (DlCOcorr), expressing the results as percent predicted and lower limit of normal (LLN) values, and we also assessed functional exercise capacity (6-minute-walk distance)...
September 2016: Annals of the American Thoracic Society
Nicola Ciancio, Claudio M Sanguinetti, Franco Falcone, Claudio Taranto, Roberto Fasani, Fernando De Benedetto, Onofrio Resta, Fausto De Michele, Roberto Messina, Andrea Rossi, Stefano Nardini, Giuseppe Di Maria
BACKGROUND: The present study reports the results of a survey jointly carried out by three Italian respiratory scientific associations (AIMAR, AIPO, SIMeR) together with an important Federation of elderly patients (FederAnziani) during the National Conference of Italian Court for Health Right held in Rimini from November 29(th) to December 1(st), 2013. The survey, based on a spirometric examination preceded by a questionnaire on respiratory health, was conducted on elderly people coming from all Italian regions to attend the Conference...
2016: Multidisciplinary Respiratory Medicine
Robert J Fox, Andrew Chan, Ralf Gold, J Theodore Phillips, Krzysztof Selmaj, Ih Chang, Mark Novas, Jitesh Rana, Jing L Marantz
BACKGROUND: Delayed-release dimethyl fumarate (DMF), indicated for the treatment of patients with relapsing-remitting multiple sclerosis (MS), is a disease-modifying therapy with potential immunomodulatory and neuroprotective effects. In clinical trials, DMF was associated with reduced white blood cell and absolute lymphocyte counts. Current US prescribing information recommends obtaining a complete blood count, including absolute lymphocyte count (ALC), before initiating and during DMF treatment...
June 2016: Neurology. Clinical Practice
Teresa Del Castillo-Santaella, Julia Maldonado-Valderrama, Jose Antonio Molina-Bolivar, Francisco Galisteo-Gonzalez
Human serum albumin (HSA) has been shown to be an ideal protein for nanoparticle preparation. These are usually prepared by using cross linker agents such as glutaraldehyde (GAD). Liquid lipid nanocapsules (LLN) constitute a new generation of nanoparticles more biocompatible and versatile for oral delivery of lipophylic drugs. The first barrier that an orally administered formulation must cross is the gastrointestinal tract. Hence, it is crucial to address the impact of gastrointestinal digestion on these structures in order to achieve an optimal formulation...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
Akiyo Matsumoto, Kaida Arita
BACKGROUND: Conventional open lateral lymph node (LLN) dissection performed along the internal iliac vessels frequently results in increased bleeding and postoperative complications [1, 2]. However, laparoscopic LLN dissection is a feasible, oncologically acceptable alternative [3-6]. We have developed a laparoscopic autonomic nerve-preserving technique for LLN dissection based on the vesicohypogastric fascia (VF) and ureterohypogastric nerve fascia (UNF) [7]. METHODS: Surgical and oncological outcomes were compared between 12 patients undergoing laparoscopic hemi-LLN dissection and 13 patients undergoing conventional open hemi-LLN dissection...
June 20, 2016: Surgical Endoscopy
Thomas P Lodise, Monique R Bidell, Shawn D Flanagan, Evan J Zasowski, Sonia L Minassian, Philippe Prokocimer
OBJECTIVES: Tedizolid is a novel oxazolidinone antibacterial. Oxazolidinones carry concerns for time-dependent myelosuppression. To further explore tedizolid's haematological tolerability, we analysed data from a 21 day study comparing safety and pharmacokinetics of tedizolid and linezolid. METHODS: This was a Phase 1 study in healthy volunteers comparing five treatments (each n = 8) over 21 days: tedizolid at 200, 300 or 400 mg once daily; linezolid at 600 mg twice daily; and placebo...
September 2016: Journal of Antimicrobial Chemotherapy
Wanchai Dejsomritrutai, Benjamas Chuaychoo
BACKGROUND: Previous analysis of survey data from a study in older urban Thai persons reported prevalence of chronic obstructive pulmonary disease (COPD) of 7.11% according to formerly recommended criteria that used fixed ratio (70%) of pre-bronchodilator FEV1/FVC as the cut-off value. In 2012, the Global Lung Initiative (GLI)-2012 equations for spirometric reference were established and the diagnostic criteria for COPD were changed. OBJECTIVE: To reanalyze the data collected during the 2002 respiratory health survey to determine prevalence of COPD in older urban Thai persons according to the new GLI-2012 equations...
March 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
William L Eschenbacher
Airflow obstruction has been defined using spirometric test results when the forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) ratio is below a fixed cutoff (<70%) or lower limits of normal (LLN) from reference equations that are based on values from a normal population. However, similar to other positive or abnormal diagnostic test results that are used to identify the presence of disease, perhaps airflow obstruction should be defined based on the values of FEV1/FVC for a population of individuals with known disease such as chronic obstructive pulmonary disease (COPD)...
2016: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
Kirsten J McCaffery, Suzanne Morony, Danielle M Muscat, Sian K Smith, Heather L Shepherd, Haryana M Dhillon, Andrew Hayen, Karen Luxford, Wedyan Meshreky, John Comings, Don Nutbeam
BACKGROUND: People with low literacy and low health literacy have poorer health outcomes. Literacy and health literacy are distinct but overlapping constructs that impact wellbeing. Interventions that target both could improve health outcomes. METHODS/DESIGN: This is a cluster randomised controlled trial with a qualitative component. Participants are 300 adults enrolled in basic language, literacy and numeracy programs at adult education colleges across New South Wales, Australia...
2016: BMC Public Health
Kimberly D Brewer, Drew R DeBay, Iulia Dude, Christa Davis, Kerry Lake, Cathryn Parsons, Rajkannan Rajagopalan, Genevieve Weir, Marianne M Stanford, Marc Mansour, Chris V Bowen
There is currently a lack of biomarkers to help properly assess novel immunotherapies at both the preclinical and clinical stages of development. Recent work done by our group indicated significant volume changes in the vaccine draining right lymph node (RLN) volumes of mice that had been vaccinated with DepoVaxTM, a lipid-based vaccine platform that was developed to enhance the potency of peptide-based vaccines. These changes in lymph node (LN) volume were unique to vaccinated mice.To better assess the potential of volumetric LN markers for multiple vaccination platforms, we evaluated 100 tumor bearing mice and assessed their response to vaccination with either a DepoVax based vaccine (DPX) or a water-in-oil emulsion (w/o), and compared them to untreated controls...
May 24, 2016: Oncotarget
Véronique Nève, Sébastien Hulo, Jean-Louis Edmé, Sophie Boileau, Georges Baquet, Guillaume Pouessel, Caroline Thumerelle, Antoine Deschildre, Régis Matran
Uncontrolled wheezing disorder is common in preschoolers and disease control assessment is challenging as parents frequently overestimate the extent to which their child's disease is controlled. This is the first study of forced expiratory volume in t s (FEVt)/forced vital capacity (FVC) ratio measurements (i.e. FEV1/FVC, FEV0.75/FVC and FEV0.5/FVC) in wheezy preschoolers in relation to disease control. Our objective was to evaluate whether FEVt/FVC ratios less than the lower limit of normal (LLN; z-score <-1...
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Thibaud Soumagne, Pierantonio Laveneziana, Matthieu Veil-Picard, Alicia Guillien, Frédéric Claudé, Marc Puyraveau, Isabella Annesi-Maesano, Nicolas Roche, Jean-Charles Dalphin, Bruno Degano
BACKGROUND: The relevance of screening for airway obstruction in subjects not complaining of COPD symptoms may depend on the definition of airway obstruction. Response to exercise in asymptomatic subjects with persistent airway obstruction as defined by a postbronchodilator FEV1/FVC <5th centile lower limit of normal (LLN) remains unknown. METHODS: Dyspnoea (Borg scale), exercise tolerance and ventilatory constraints on tidal volume expansion were assessed in 20 consecutive asymptomatic subjects with persistent mild airway obstruction detected by screening (postbronchodilator FEV1/FVC z-score: -2...
September 2016: Thorax
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