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https://www.readbyqxmd.com/read/27899005/angle-%C3%AE-of-greater-than-80%C3%A2-at-the-start-of-spirometry-may-identify-high-quality-flow-volume-curves
#1
Ningfang Lian, Li Li, Weiying Ren, Zhilong Jiang, Lei Zhu
BACKGROUND AND OBJECTIVE: The American Thoracic Society (ATS) and European Respiratory Society (ERS) emphasize a satisfactory start in maximal expiratory flow-volume (MEFV) curves and highlight subjective parameters: performance without hesitation and expiration with maximum force. We described a new parameter, angle β for characterization of the start to the MEFV curve. METHODS: Subjects completed the MEFV curve at least three times and at least two curves met ATS/ERS quality...
November 29, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27884204/lateral-pelvic-lymph-node-dissection-after-neoadjuvant-chemo-radiation-for-preoperative-enlarged-lateral-nodes-in-advanced-low-rectal-cancer-study-protocol-for-a-randomized-controlled-trial
#2
Mingtian Wei, Qingbin Wu, Chuanwen Fan, Yan Li, Xiangzheng Chen, Zongguang Zhou, Junhong Han, Ziqiang Wang
BACKGROUND: Lateral lymph node (LLN) metastasis is a major cause of local recurrence of advanced rectal cancer. Although there is much controversy between Western and Eastern countries on whether lateral pelvic lymph node dissection (LLND) or neoadjuvant chemo-radiation (nCRT) is preferable for the treatment of LLN metastases, existing retrospective cohorts mainly focus on all middle/low advanced rectal cancer patients, not the specific individuals with suspicion of LLN metastases. The aim of this trial is to assess the efficacy and safety of LLND for rectal cancer patients with suspicion of LLN metastases...
November 25, 2016: Trials
https://www.readbyqxmd.com/read/27880044/tuberculosis-airway-obstruction-and-mortality-in-a-finnish-population
#3
Tiina Mattila, Markku Heliövaara, Harri Rissanen, Paul Knekt, Pauli Puukka, Tuula Vasankari
There is little long-term follow-up data concerning the association between past pulmonary tuberculosis (TB), airway obstruction and mortality. We aimed to analyse a national health examination survey data from 6701 adult Finns undergoing spirometry between 1978 and 1980 (follow-up through 2013). We identified TB either through a disease history or by a TB-indicative scar on a chest x-ray. We specified obstruction using the lower limit of normal (LLN) and classified severity using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages 1-4...
November 23, 2016: COPD
https://www.readbyqxmd.com/read/27824594/global-lung-function-initiative-2012-reference-equations-for-spirometry-in-the-norwegian-population
#4
Arnulf Langhammer, Ane Johannessen, Turid L Holmen, Hasse Melbye, Sanja Stanojevic, May B Lund, Morten N Melsom, Per Bakke, Philip H Quanjer
We studied the fit of the Global Lung Function Initiative (GLI) all-age reference values to Norwegians, compared them with currently used references (European Community for Steel and Coal (ECSC) and Zapletal) and estimated the prevalence of obstructive lung disease.Spirometry data collected in 30 239 subjects (51.7% females) aged 12-90 years in three population-based studies were converted to z-scores.We studied healthy non-smokers comprising 2438 adults (57.4% females) aged 20-90 years and 8725 (47.7% female) adolescents aged 12-19 years...
December 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27817808/restrictive-spirometric-pattern-in-the-general-adult-population-methods-of-defining-the-condition-and-consequences-on-prevalence
#5
Helena Backman, Berne Eriksson, Linnea Hedman, Caroline Stridsman, Sven-Arne Jansson, Anssi Sovijärvi, Anne Lindberg, Eva Rönmark, Bo Lundbäck
BACKGROUND: Attempts have been made to use dynamic spirometry to define restrictive lung function, but the definition of a restrictive spirometric pattern (RSP) varies between studies such as BOLD and NHANES. The aim of this study was to estimate the prevalence and risk factors of RSP among adults in northern Sweden based on different definitions. METHODS: In 2008-2009 a general population sample aged 21-86y within the obstructive lung disease in northern Sweden (OLIN) studies was examined by structured interview and spirometry, and 726 subjects participated (71% of invited)...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27817804/a-comparison-of-five-surveys-that-identify-individuals-at-risk-for-airflow-obstruction-and-chronic-obstructive-pulmonary-disease
#6
Folarin Sogbetun, William L Eschenbacher, Jeffrey A Welge, Ralph J Panos
BACKGROUND: The predictive characteristics of different screening surveys for the recognition of individuals at risk for airflow obstruction (AFO) have not been evaluated simultaneously in the same population. PURPOSE: To compare five AFO/COPD screening questionnaires. METHODS: 383 individuals completed the Veterans Airflow Obstruction Screening Questionnaire, Personal Level Screener for COPD (VAFOSQ), the 11-Q COPD Screening Questionnaire (11-Q), the COPD Population Screener (COPD-PS) and the Lung Function Questionnaire (LFQ) and performed spirometry...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27730176/maximal-aerobic-capacity-in-ageing-subjects-actual-measurements-versus-predicted-values
#7
Cristina Pistea, Evelyne Lonsdorfer, Stéphane Doutreleau, Monique Oswald, Irina Enache, Anne Charloux
We evaluated the impact of selection of reference values on the categorisation of measured maximal oxygen consumption (V'O2peak) as "normal" or "abnormal" in an ageing population. We compared measured V'O2peak with predicted values and the lower limit of normal (LLN) calculated with five equations. 99 (58 males and 41 females) disease-free subjects aged ≥70 years completed an incremental maximal exercise test on a cycle ergometer. Mean V'O2peak was 1.88 L·min(-1) in men and 1.26 L·min(-1) in women...
January 2016: ERJ Open Research
https://www.readbyqxmd.com/read/27696765/lung-function-respiratory-symptoms-and-venous-thromboembolism-risk-the-atherosclerosis-risk-in-communities-study
#8
Yasuhiko Kubota, Stephanie J London, Mary Cushman, Alanna M Chamberlain, Wayne D Rosamond, Susan R Heckbert, Neil Zakai, Aaron R Folsom
BACKGROUND: The evidence of the association between chronic obstructive pulmonary disease (COPD) and venous thromboembolism (VTE) is limited. There is no study investigating the association of restrictive lung disease (RLD) and respiratory symptoms with VTE. OBJECTIVES: To investigate prospectively the association of lung function and respiratory symptoms with VTE. PATIENTS/METHODS: In 1987-1989, we assessed lung function using spirometry and obtained information on respiratory symptoms (cough, phlegm and dyspnea) in 14 654 participants aged 45-64, without a history of VTE or anticoagulant use, and followed them through 2,011...
October 1, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27684728/should-the-diagnosis-of-copd-be-based-on-a-single-spirometry-test
#9
Tjard R Schermer, Bas Robberts, Alan J Crockett, Bart P Thoonen, Annelies Lucas, Joke Grootens, Ivo J Smeele, Cindy Thamrin, Helen K Reddel
Clinical guidelines indicate that a chronic obstructive pulmonary disease (COPD) diagnosis is made from a single spirometry test. However, long-term stability of diagnosis based on forced expiratory volume in 1 s over forced vital capacity (FEV1/FVC) ratio has not been reported. In primary care subjects at risk for COPD, we investigated shifts in diagnostic category (obstructed/non-obstructed). The data were from symptomatic 40+ years (ex-)smokers referred for diagnostic spirometry, with three spirometry tests, each 12±2 months apart...
September 29, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27660514/lower-lung-function-associates-with-cessation-of-menstruation-uk-biobank-data
#10
André F S Amaral, David P Strachan, Francisco Gómez Real, Peter G J Burney, Deborah L Jarvis
Little is known about the effect of cessation of menstruation on lung function. The aims of the study were to examine the association of lung function with natural and surgical cessation of menstruation, and assess whether lower lung function is associated with earlier age at cessation of menstruation.The study was performed in 141 076 women from the UK Biobank, who had provided acceptable and reproducible spirometry measurements and information on menstrual status. The associations of lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), spirometric restriction (FVC < lower limit of normal (LLN)), airflow obstruction (FEV1/FVC <LLN)) with cessation of menstruation and age at cessation of menstruation were assessed using regression analysis...
November 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27651103/radium-223-use-in-clinical-practice-and-variables-associated-with-completion-of-therapy
#11
Rana R McKay, Susanna Jacobus, Matthew Fiorillo, Elisa M Ledet, Patrick M Cotogna, Allie E Steinberger, Heather A Jacene, Oliver Sartor, Mary-Ellen Taplin
BACKGROUND: Radium-223 has shown clinical efficacy in metastatic castration-resistant prostate cancer. Despite improvement in quality of life and survival, practice patterns and utility of this agent outside the context of clinical trials have not been fully characterized. The primary objective in this study was to evaluate variables associated with completion of 5 to 6 radium-223 doses. PATIENTS AND METHODS: We conducted retrospective analyses of patients who received radium-223 (n = 135)...
August 20, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27574413/what-is-the-impact-of-different-spirometric-criteria-on-the-prevalence-of-spirometrically-defined-copd-and-its-comorbidities-results-from-the-population-based-kora-study
#12
Stefan Karrasch, Irene Brüske, Maia P Smith, Barbara Thorand, Cornelia Huth, Karl-Heinz Ladwig, Florian Kronenberg, Joachim Heinrich, Rolf Holle, Annette Peters, Holger Schulz
BACKGROUND: There is an ongoing debate about the appropriate spirometric criterion for airway obstruction to detect COPD. Furthermore, the association of different criteria with comorbidity prevalence and inflammatory biomarkers in advanced age is unclear. MATERIALS AND METHODS: Spirometry was performed in a population-based study (n=2,256) covering an age range of 41-90 years. COPD was spirometrically determined either by a fixed ratio (FR) of <0.7 for forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) or by FEV1/FVC below the lower limit of normal (LLN)...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27490554/bindings-and-restlets-a-novel-set-of-coap-based-application-enablers-to-build-iot-applications
#13
Girum Ketema Teklemariam, Floris Van Den Abeele, Ingrid Moerman, Piet Demeester, Jeroen Hoebeke
Sensors and actuators are becoming important components of Internet of Things (IoT) applications. Today, several approaches exist to facilitate communication of sensors and actuators in IoT applications. Most communications go through often proprietary gateways requiring availability of the gateway for each and every interaction between sensors and actuators. Sometimes, the gateway does some processing of the sensor data before triggering actuators. Other approaches put this processing logic further in the cloud...
2016: Sensors
https://www.readbyqxmd.com/read/27428328/use-the-lower-limit-of-normal-not-80-predicted-in-judging-eligibility-for-lung-resection
#14
Stefan P Wesolowski, Piotr W Boros, Tadeusz M Orłowski, Philip H Quanjer
BACKGROUND: Impaired lung function (LF) is a well-known risk factor for perioperative complications in patients qualified for lung resection surgery. The recent European guidelines recommend using values below 80% predicted as indicating abnormal LF rather than the lower limit of normal (LLN). OBJECTIVES: To assess how the choice of a cut-off point (80% predicted vs. LLN at -1.645 SD) affects the incidence of functional disorders and postoperative complications in lung cancer patients referred for lung resection...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27391297/pulmonary-function-after-treatment-for-childhood-cancer-a-report-from-the-st-jude-lifetime-cohort-study-sjlife
#15
Daniel M Green, Liang Zhu, Mingjuan Wang, Kirsten K Ness, Matthew J Krasin, Nickhill H Bhakta, M Beth McCarville, Saumini Srinivasan, Dennis C Stokes, DeoKumar Srivastava, Rohit Ojha, Kyla Shelton, Ching-Hon Pui, Gregory T Armstrong, Daniel A Mulrooney, Monika Metzger, Sheri L Spunt, Fariba Navid, Andrew M Davidoff, Bhaskar N Rao, Leslie L Robison, Melissa M Hudson
RATIONALE: The relationship between treatment-related impairment of pulmonary function in adult survivors of childhood cancer and subsequent physical function has not been studied. OBJECTIVES: In this prospective evaluation of 606 adult survivors of childhood cancer, we sought to determine the risk factors for, as well as the functional impact of, clinically ascertained pulmonary function impairment. METHODS: We measured FEV1, FVC, total lung capacity (TLC), and single-breath diffusing capacity of the lung for carbon monoxide corrected for hemoglobin (DlCOcorr), expressing the results as percent predicted and lower limit of normal (LLN) values, and we also assessed functional exercise capacity (6-minute-walk distance)...
September 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27382464/most-italians-attending-a-congress-on-health-of-elderly-people-do-not-know-and-do-not-recognize-respiratory-diseases
#16
Nicola Ciancio, Claudio M Sanguinetti, Franco Falcone, Claudio Taranto, Roberto Fasani, Fernando De Benedetto, Onofrio Resta, Fausto De Michele, Roberto Messina, Andrea Rossi, Stefano Nardini, Giuseppe Di Maria
BACKGROUND: The present study reports the results of a survey jointly carried out by three Italian respiratory scientific associations (AIMAR, AIPO, SIMeR) together with an important Federation of elderly patients (FederAnziani) during the National Conference of Italian Court for Health Right held in Rimini from November 29(th) to December 1(st), 2013. The survey, based on a spirometric examination preceded by a questionnaire on respiratory health, was conducted on elderly people coming from all Italian regions to attend the Conference...
2016: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/27347439/characterizing-absolute-lymphocyte-count-profiles-in-dimethyl-fumarate-treated-patients-with-ms-patient-management-considerations
#17
Robert J Fox, Andrew Chan, Ralf Gold, J Theodore Phillips, Krzysztof Selmaj, Ih Chang, Mark Novas, Jitesh Rana, Jing L Marantz
BACKGROUND: Delayed-release dimethyl fumarate (DMF), indicated for the treatment of patients with relapsing-remitting multiple sclerosis (MS), is a disease-modifying therapy with potential immunomodulatory and neuroprotective effects. In clinical trials, DMF was associated with reduced white blood cell and absolute lymphocyte counts. Current US prescribing information recommends obtaining a complete blood count, including absolute lymphocyte count (ALC), before initiating and during DMF treatment...
June 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/27341303/effect-of-cross-linker-glutaraldehyde-on-gastric-digestion-of-emulsified-albumin
#18
Teresa Del Castillo-Santaella, Julia Maldonado-Valderrama, Jose Antonio Molina-Bolivar, Francisco Galisteo-Gonzalez
Human serum albumin (HSA) has been shown to be an ideal protein for nanoparticle preparation. These are usually prepared by using cross linker agents such as glutaraldehyde (GAD). Liquid lipid nanocapsules (LLN) constitute a new generation of nanoparticles more biocompatible and versatile for oral delivery of lipophylic drugs. The first barrier that an orally administered formulation must cross is the gastrointestinal tract. Hence, it is crucial to address the impact of gastrointestinal digestion on these structures in order to achieve an optimal formulation...
September 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27324330/a-technique-of-laparoscopic-lateral-pelvic-lymph-node-dissection-based-on-vesicohypogastric-fascia-and-ureterohypogastric-nerve-fascia-for-advanced-low-rectal-cancer
#19
Akiyo Matsumoto, Kaida Arita
BACKGROUND: Conventional open lateral lymph node (LLN) dissection performed along the internal iliac vessels frequently results in increased bleeding and postoperative complications [1, 2]. However, laparoscopic LLN dissection is a feasible, oncologically acceptable alternative [3-6]. We have developed a laparoscopic autonomic nerve-preserving technique for LLN dissection based on the vesicohypogastric fascia (VF) and ureterohypogastric nerve fascia (UNF) [7]. METHODS: Surgical and oncological outcomes were compared between 12 patients undergoing laparoscopic hemi-LLN dissection and 13 patients undergoing conventional open hemi-LLN dissection...
June 20, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27317442/characterization-of-the-haematological-profile-of-21-days-of-tedizolid-in-healthy-subjects
#20
Thomas P Lodise, Monique R Bidell, Shawn D Flanagan, Evan J Zasowski, Sonia L Minassian, Philippe Prokocimer
OBJECTIVES: Tedizolid is a novel oxazolidinone antibacterial. Oxazolidinones carry concerns for time-dependent myelosuppression. To further explore tedizolid's haematological tolerability, we analysed data from a 21 day study comparing safety and pharmacokinetics of tedizolid and linezolid. METHODS: This was a Phase 1 study in healthy volunteers comparing five treatments (each n = 8) over 21 days: tedizolid at 200, 300 or 400 mg once daily; linezolid at 600 mg twice daily; and placebo...
September 2016: Journal of Antimicrobial Chemotherapy
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