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https://www.readbyqxmd.com/read/29676626/chronic-obstructive-pulmonary-disease-and-herbicide-exposure-in-vietnam-era-u-s-army-chemical-corps-veterans
#1
Yasmin Cypel, Stella E Hines, Victoria J Davey, Stephanie M Eber, Aaron I Schneiderman
RATIONALE: Past research demonstrates a possible association between herbicide exposure and respiratory health. Biologic plausibility and inhalation as a mode of exposure further support the contention that herbicides may act as adverse contributors to respiratory status, especially in military personnel who were responsible for chemical maintenance and distribution during the Vietnam War. OBJECTIVES: This study examines the association between chronic obstructive pulmonary disease and herbicide exposure among Vietnam-era U...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29553052/spirometric-reference-equations-for-elderly-chinese-in-jinan-aged-60-84-years
#2
Xin-Yu Tian, Chun-Hong Liu, De-Xiang Wang, Xiu-Li Ji, Hui Shi, Chun-Yan Zheng, Meng-Shuang Xie, Wei Xiao
Background: The interpretation of spirometry varies on different reference values. Older people are usually underrepresented in published predictive values. This study aimed at developing spirometric reference equations for elderly Chinese in Jinan aged 60-84 years and to compare them to previous equations. Methods: The project covered all of Jinan city, and the recruitment period lasted 9 months from January 1, 2017 to September 30, 2017, 434 healthy people aged 60-84 years who had never smoked (226 females and 208 males) were recruited to undergo spirometry...
March 19, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29504008/on-the-contribution-of-f-electrons-to-the-quadratic-hyperpolarizability-the-case-of-lanthanide-terpyridyl-complexes
#3
Fatima Ibersiene, Camille Latouche, Claudine Katan, Abdou Boucekkine
Over the last decades, trivalent lanthanide ions (Ln3+ ) have gained much attention due to their peculiar luminescence, which opened the way to a broad range of applications, from medical diagnostic to lasers. Their impact on nonlinear optical (NLO) properties also attracted interest, especially in the framework of lanthanide complexes. Several experimental studies demonstrated that the quadratic hyperpolarizability varies with the number of 4f-electrons, with a stronger effect on dipolar than octupolar components...
March 5, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29471218/albumin-covered-lipid-nanocapsules-exhibit-enhanced-uptake-performance-by-breast-tumor-cells
#4
F Galisteo-González, J A Molina-Bolívar, S A Navarro, H Boulaiz, A Aguilera-Garrido, A Ramírez, J A Marchal
Liquid lipid nanocapsules (LLN) represent a promising new generation of drug-delivery systems. They can carry hydrophobic drugs in their oily core, but the composition and structure of the surrounding protective shell determine their capacity to survive in the circulatory system and to achieve their goal: penetrate tumor cells. Here, we present a study of LLN covered by the protein human serum albumin (HSA) and loaded with curcumin as a hydrophobic model drug. A cross-linking procedure was performed to further strengthen the protective protein layer...
February 13, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29449425/young-and-middle-aged-adults-with-airflow-limitation-according-to-lower-limit-of-normal-but-not-fixed-ratio-have-high-morbidity-and-poor-survival-a-population-based-prospective-cohort-study
#5
Yunus Çolak, Shoaib Afzal, Børge G Nordestgaard, Jørgen Vestbo, Peter Lange
A presumed consequence of using a fixed ratio for the definition of airflow limitation (AFL) has been overdiagnosis among older individuals and underdiagnosis among younger individuals. However, the prognosis of younger individuals with potentially underdiagnosed AFL is poorly described. We hypothesised that potential underdiagnosis of AFL at a younger age is associated with poor prognosis.We assigned 95 288 participants aged 20-100 years from the Copenhagen General Population Study into the following groups: individuals without AFL with forced expiratory volume in 1 s (FEV1 )/forced vital capacity (FVC) ≥0...
March 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29439716/risk-factors-of-lateral-lymph-node-metastasis-in-cn0-papillary-thyroid-carcinoma
#6
Daixing Hu, Jing Zhou, Wei He, Jie Peng, Yijia Cao, Haoyu Ren, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Xinliang Su
BACKGROUND: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. METHODS: We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection...
February 13, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29420087/prevalence-and-features-of-asthma-chronic-obstructive-pulmonary-disease-overlap-in-northern-italy-general-population
#7
Massimo Guerriero, Marco Caminati, Giovanni Viegi, Gianenrico Senna, Carlo Pomari
OBJECTIVE: There is controversy about the diagnostic criteria, prevalence, symptoms, and spirometry characteristics of asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO). Recent data indicate that the fixed method for diagnosing airway obstruction (AO) may overestimate ACO prevalence in the elderly, and a variable method may be more accurate. We aimed at estimating ACO prevalence in a general population sample and comparing patient and clinical features in subjects with ACO, COPD, and asthma...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29394649/-a-curatively-resected-case-of-lateral-lymph-node-metastasis-five-years-after-initial-surgery-for-rectal-cancer
#8
Takayuki Miura, Takazumi Tsunenari, Tsuyoshi Sasaki, Tadaaki Yokoyama, Kenji Fukuhara
A 74-year-old male had undergone laparoscopic abdominoperineal resection for lower rectal cancer in July 2009. The pathological diagnosis was T2, N0, M0, pStage I (TNM 7th). Because of pathological venous invasion, adjuvant chemotherapy with Tegafur-uracil(UFT)plus Leucovorin for a year was performed. A CT examination revealed slowly growing peripheral right internal iliaclymph node. PET-CT demonstrated a 20mm right lateral lymph node(LLN)metastasis without other distant metastases. On diagnosis of solitary LLN metastasis of rectal cancer, the patient underwent surgical lymph node resection in September 2014...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29342980/dietary-intake-of-flavonoids-and-ventilatory-function-in-european-adults-a-ga%C3%A2-len-study
#9
Vanessa Garcia-Larsen, Narjis Thawer, David Charles, Aedin Cassidy, Thibaut van Zele, Trine Thilsing, Matti Ahlström, Tari Haahtela, Thomas Keil, Paolo M Matricardi, Grzegorz Brożek, Marek L Kowalski, Joanna Makowska, Ewa Niżankowska-Mogilnicka, Barbara Rymarczyk, Carlos Loureiro, Ana Todo Bom, Claus Bachert, Bertil Forsberg, Christer Janson, Kjell Torén, James F Potts, Peter Gj Burney
BACKGROUND: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. METHODS: A stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV₁) and FVC (FEV₁/FVC), FVC below lower limit of normal (FVC < LLN), and FEV₁/FVC < LLN were calculated...
January 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29332652/initial-airflow-obstruction-in-new-cases-of-pulmonary-tuberculosis-complication-comorbidity-or-missed
#10
Andrii Dudnyk, Svitlana Blyzniuk, Oleksandr Pavel'chuk, Olena Zakharchenko, Dmytro Butov, Sergiі Zaіkov
Tuberculosis (TB) may have a similar spirometry findings as a chronic obstructive pulmonary disease but the prevalence of TB-induced airflow obstruction (AO) is still unknown. OBJECTIVES: To measure frequency of AO in new TB cases at the beginning of treatment and to evaluate factors associated with obstructive abnormalities following TB diagnosis. MATERIALS AND METHODS: 317 patients that have no history of prior AO were recruited into the study with a median age of 39...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29331988/airflow-limitation-in-people-living-with-hiv-and-matched-uninfected-controls
#11
Andreas Ronit, Jens Lundgren, Shoaib Afzal, Thomas Benfield, Ashley Roen, Amanda Mocroft, Jan Gerstoft, Børge G Nordestgaard, Jørgen Vestbo, Susanne D Nielsen
INTRODUCTION: Whether HIV influences pulmonary function remains controversial. We assessed dynamic pulmonary function in people living with HIV (PLWHIV) and uninfected controls. METHODS: A total of 1098 PLWHIV from the Copenhagen Co-morbidity in HIV infection study and 12 161 age-matched and sex-matched controls from the Copenhagen General Population Study were included. Lung function was assessed using FEV1 and FVC, while airflow limitation was defined by the lower limit of normal (LLN) of FEV1 /FVC and by FEV1 /FVC<0...
January 13, 2018: Thorax
https://www.readbyqxmd.com/read/29250530/the-impact-of-different-spirometric-definitions-on-the-prevalence-of-airway-obstruction-and-their-association-with-respiratory-symptoms
#12
Howraman Meteran, Martin R Miller, Simon Francis Thomsen, Kaare Christensen, Torben Sigsgaard, Vibeke Backer
The fixed ratio criterion of forced expiratory volume in 1 s/forced vital capacity <0.70 for diagnosing airway obstruction may overdiagnose the condition, particularly in the elderly, so the lower limit of normal (LLN) is recommended as the most appropriate criterion. Our aim was to compare LLN versus fixed ratio on the prevalence of chronic obstructive pulmonary disease (COPD) and examine the association between respiratory symptoms and airway obstruction defined by LLN and fixed ratio. 12 449 twins aged 40-80 years participated in a nationwide survey using the Danish Twin Registry...
October 2017: ERJ Open Research
https://www.readbyqxmd.com/read/29238185/occupational-exposure-to-vapor-gas-dust-or-fumes-and-chronic-airflow-limitation-copd-and-emphysema-the-swedish-cardiopulmonary-bioimage-study-scapis-pilot
#13
Kjell Torén, Jenny Vikgren, Anna-Carin Olin, Annika Rosengren, Göran Bergström, John Brandberg
Background: The aim of this study was to estimate the occupational burden of airflow limitation, chronic airflow limitation, COPD, and emphysema. Materials and methods: Subjects aged 50-64 years (n=1,050) were investigated with forced expiratory volume in 1 s (FEV1 ) and forced vital capacity (FVC). Airflow limitation was defined as FEV1 /FVC <0.7 before bronchodilation. Chronic airflow limitation was defined after bronchodilation either according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) as FEV1 /FVC <0...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29228947/estimating-prevalence-of-chronic-obstructive-pulmonary-disease-in-the-southern-cone-of-latin-america-how-different-spirometric-criteria-may-affect-disease-burden-and-health-policies
#14
Edgardo Sobrino, Vilma E Irazola, Laura Gutierrez, Chung-Shiuan Chen, Fernando Lanas, Matías Calandrelli, Jacqueline Ponzo, Nora Mores, Pamela Serón, Allison Lee, Jiang He, Adolfo L Rubinstein
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. The study aimed to determine and compare the prevalence of COPD in the general population aged 45-74 years old according to fixed ratio and lower limit of normal (LLN) thresholds in four cities in the Southern Cone of Latin America. METHODS: The Pulmonary Risk in South America (PRISA) study used a 4-stage stratified sampling method to select 5814 participants from 4 cities in the Southern Cone of Latin America (Bariloche and Marcos Paz, Argentina; Temuco, Chile; and Pando-Barros Blancos, Uruguay)...
December 11, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29215803/reference-values-for-spirometry-derived-using-lambda-mu-sigma-lms-method-in-korean-adults-in-comparison-with-previous-references
#15
Bum Seak Jo, Jun Pyo Myong, Chin Kook Rhee, Hyoung Kyu Yoon, Jung Wan Koo, Hyoung Ryoul Kim
BACKGROUND: The present study aimed to update the prediction equations for spirometry and their lower limits of normal (LLN) by using the lambda, mu, sigma (LMS) method and to compare the outcomes with the values of previous spirometric reference equations. METHODS: Spirometric data of 10,249 healthy non-smokers (8,776 females) were extracted from the fourth and fifth versions of the Korea National Health and Nutrition Examination Survey (KNHANES IV, 2007-2009; V, 2010-2012)...
January 15, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29206635/domestic-solid-fuel-combustion-in-an-adult-population-in-nigeria-a-cross-sectional-analysis-of-association-with-respiratory-symptoms-quality-of-life-and-lung-function
#16
Daniel O Obaseki, Olayemi F Awopeju, Babatunde I Awokola, Bamidele O Adeniyi, Bolanle O Adefuye, Obianuju B Ozoh, Godsent C Isiguzo, Ganiyu A Amusa, Olufemi O Adewole, Gregory E Erhabor
BACKGROUND AND OBJECTIVES: We examined the association of respiratory symptoms, health status, and lung function with the use of solid fuel (wood, charcoal, coal or crop residue) for cooking or heating in a predominantly non-smoking population. METHODS: Using the protocol of the Burden of Obstructive Lung Diseases (BOLD) initiative, we collected representative population data using questionnaires and spirometry tests. We categorized solid fuel use into 'never user', 'ex user' and 'current user' based on responses to the survey...
September 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29172491/nonchelated-phosphoniomethylidene-complexes-of-scandium-and-lutetium
#17
Weiqing Mao, Li Xiang, Laurent Maron, Xuebing Leng, Yaofeng Chen
The first phosphoniomethylidene complexes of scandium and lutetium, [LLn(CHPPh3 )X] (L = [MeC(NDIPP)CHC(NDIPP)Me]- ; Ln = Sc, X = Me, I, TfO; Ln = Lu, X = CH2 SiMe3 ), have been synthesized and fully characterized. DFT calculations clearly demonstrate the presence of an allylic Ln, C, P π-type interaction in these complexes. X-ray diffraction indicates that the scandium iodide complex has the shortest Sc-C bond length to date (2.044(5) Å). These phosphoniomethylidene complexes readily convert into the ylide complexes, and the reactivity is affected by both X- anion and Ln3+ ion...
December 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29079449/prospective-study-of-lung-function-and-abdominal-aortic-aneurysm-risk-the-atherosclerosis-risk-in-communities-study
#18
Yasuhiko Kubota, Aaron R Folsom, Kunihiro Matsushita, David Couper, Weihong Tang
BACKGROUND AND AIMS: No prospective study has investigated whether individuals with respiratory impairments, including chronic obstructive pulmonary disease (COPD) and restrictive lung disease (RLD), are at increased risk of abdominal aortic aneurysm (AAA). We aimed to prospectively investigate whether those respiratory impairments are associated with increased AAA risk. METHODS: In 1987-1989, the Atherosclerosis Risk in Communities (ARIC) study followed 14,269 participants aged 45-64 years, without a history of AAA surgery, through 2011...
January 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29070029/skip-metastasis-in-papillary-thyroid-carcinoma-is-difficult-to-predict-in-clinical-practice
#19
Xilin Nie, Zhou Tan, Minghua Ge
BACKGROUND: Cervical lymph node metastases are very common in papillary thyroid cancer (PTC), and typically spread in a predictable stepwise fashion in clinical practice. However, lateral lymph node metastasis (LLNM) without central lymph node metastasis (CLNM) as skip metastasis is not rare in PTC. The aim of this study was to investigate the incidence, risk factors and pattern of skip metastasis in PTC. METHODS: A total of 271 patients with PTC and suspicious LLN diagnosed by pre-operation examinations who underwent total thyroidectomy and central lymph node dissection plus lateral lymph node dissection between January 2008 and December 2011 were enrolled in this study...
October 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28947016/global-lung-function-initiative-2012-reference-values-for-spirometry-in-south-italian-children
#20
Salvatore Fasola, Stefania La Grutta, Fabio Cibella, Giovanna Cilluffo, Giovanni Viegi
RATIONALE: Despite the widespread use of the Global Lung Function Initiative (GLI) 2012 reference values, there is still the need of testing their applicability in local areas. OBJECTIVES: The aims of this study are to evaluate applicability of GLI reference equations in a large population-based sample of normal schoolchildren from Sicily, and to compare GLI and previous prediction equations in terms of spirometry test interpretation. METHODS: GLI equations were evaluated in 1243 normal schoolchildren, 49% males, aged 7-16 years, height 116-187 cm...
October 2017: Respiratory Medicine
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