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https://www.readbyqxmd.com/read/28713585/associations-of-centrally-acting-ace-inhibitors-with-cognitive-decline-and-survival-in-alzheimer-s-disease
#1
Karim Fazal, Gayan Perera, Mizanur Khondoker, Robert Howard, Robert Stewart
BACKGROUND: Cognitive improvement has been reported in patients receiving centrally acting angiotensin-converting enzyme inhibitors (C-ACEIs). AIMS: To compare cognitive decline and survival after diagnosis of Alzheimer's disease between people receiving C-ACEIs, non-centrally acting angiotensin-converting enzyme inhibitors (NC-ACEIs), and neither. METHOD: Routine Mini-Mental State Examination (MMSE) scores were extracted in 5260 patients receiving acetylcholinesterase inhibitors and analysed against C-/NC-ACEI exposure at the time of Alzheimer's disease diagnosis...
July 2017: BJPsych Open
https://www.readbyqxmd.com/read/28681740/cognition-in-advanced-normal-pressure-hydrocephalus-a-pilot-study-from-south-india
#2
Robert Mathew, Sauda Pavithran
BACKGROUND: Literature on cognition in normal pressure hydrocephalus (NPH) is sparse and more so on cognition in advanced NPH. OBJECTIVE: To study the cognitive profile in a hospital-based cohort of cognitively-advanced NPH. SETTINGS AND DESIGN: This was a prospective cross-sectional study. The patients included those availing dementia care service from three different tertiary care centres during a period of 5 years from 2010 to 2014. Patients were considered to have cognitively-advanced NPH if the Addenbrooke's Cognitive Examination(ACE) score was 50 or less...
July 2017: Neurology India
https://www.readbyqxmd.com/read/28611821/patients-with-mild-cognitive-impairment-show-lower-visual-short-term-memory-performance-in-feature-binding-tasks
#3
Raju P Sapkota, Ian van der Linde, Nirmal Lamichhane, Tirthalal Upadhyaya, Shahina Pardhan
BACKGROUND: Early cognitive changes in people at risk of developing dementia may be detected using behavioral tests that examine the performance of typically affected brain areas, such as the hippocampi. An important cognitive function supported by the hippocampi is memory binding, in which object features are associated to create a unified percept. AIM: To compare visual short-term memory (VSTM) binding performance for object names, locations, and identities between a participant group known to be at higher risk of developing dementia (mild cognitive impairment [MCI]) and healthily aging controls...
January 2017: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/28553317/meta-analysis-of-human-alzgene-database-benefits-and-limitations-of-using-c-elegans-for-the-study-of-alzheimer-s-disease-and-co-morbid-conditions
#4
Behrad Vahdati Nia, Christine Kang, Michelle G Tran, Deborah Lee, Shin Murakami
Human genome-wide association studies (GWAS) and linkage studies have identified 695 genes associated with Alzheimer's disease (AD), the vast majority of which are associated with late-onset AD. Although orthologs of these AD genes have been studied in several model species, orthologs in the nematode, Caenorhabditis elegans, remain incompletely identified, with orthologs to only 17 AD-related genes identified in the C. elegans database, WormBase. Therefore, we performed a comprehensive search for additional C...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28449585/elevated-plasma-a%C3%AE-42-in-cognitively-impaired-individuals-taking-ace-inhibitor-antihypertensives
#5
William T Regenold, Jacob B Blumenthal, David J Loreck, Kristen L Mordecai, Gina Scarinzi, Seshagiri R Doddi, Lawrence Adler
BACKGROUND/RATIONALE: Accumulating evidence suggests that the use of angiotensin-converting enzyme inhibitor (ACE-I) medication protects against cognitive decline in the elderly patients. We investigated whether ACE-I use was associated with higher plasma levels of amyloid-β (Aβ), possibly indicating improved Aβ clearance from brain to blood. METHODS: We measured and compared plasma concentrations of Aβ42, Aβ40, and creatinine in cognitively impaired individuals with amnestic mild cognitive impairment, probable Alzheimer's disease (AD) dementia, and mixed probable AD/vascular dementia...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28387670/angiotensin-iii-is-increased-in-alzheimer-s-disease-in-association-with-amyloid-%C3%AE-and-tau-pathology
#6
Patrick Gavin Kehoe, Elliott Hibbs, Laura E Palmer, J Scott Miners
Hyperactivity of the renin-angiotensin system (RAS) is associated with the pathogenesis of Alzheimer's disease (AD) believed to be mediated by angiotensin-II (Ang-II) activation of the angiotensin type 1 receptor (AT1R). We previously showed that angiotensin-converting enzyme-1 (ACE-1) activity, the rate-limiting enzyme in the production of Ang-II, is increased in human postmortem brain tissue in AD. Angiotensin-III (Ang-III) activates the AT1R and angiotensin type-2 receptor (AT2R), but its potential role in the pathophysiology of AD remains unexplored...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28384640/comparative-diagnostic-accuracy-of-the-ace-iii-mis-mmse-moca-and-rudas-for-screening-of-alzheimer-disease
#7
Jordi A Matías-Guiu, María Valles-Salgado, Teresa Rognoni, Frank Hamre-Gil, Teresa Moreno-Ramos, Jorge Matías-Guiu
BACKGROUND: Our aim was to evaluate and compare the diagnostic properties of 5 screening tests for the diagnosis of mild Alzheimer disease (AD). METHODS: We conducted a prospective and cross-sectional study of 92 patients with mild AD and of 68 healthy controls from our Department of Neurology. The diagnostic properties of the following tests were compared: Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination III (ACE-III), Memory Impairment Screen (MIS), Montreal Cognitive Assessment (MoCA), and Rowland Universal Dementia Assessment Scale (RUDAS)...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28372334/dementia-screening-accuracy-is-robust-to-premorbid-iq-variation-evidence-from-the-addenbrooke-s-cognitive-examination-iii-and-the-test-of-premorbid-function
#8
Joshua Stott, Katrina Scior, William Mandy, Georgina Charlesworth
BACKGROUND: Scores on cognitive screening tools for dementia are associated with premorbid IQ. It has been suggested that screening scores should be adjusted accordingly. However, no study has examined whether premorbid IQ variation affects screening accuracy. OBJECTIVE: To investigate whether the screening accuracy of a widely used cognitive screening tool for dementia, the Addenbrooke's cognitive examination-III (ACE-III), is improved by adjusting for premorbid IQ...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28290249/in-vitro-and-in-silico-studies-of-mangiferin-from-aphloia-theiformis-on-key-enzymes-linked-to-diabetes-type-2-and-associated-complications
#9
Marie C N Picot, Gokhan Zengin, Adriano Mollica, Azzurra Stefanucci, Simone Carradori, Mohamad F Mahomoodally
BACKGROUND: Mangiferin, was identified in the crude methanol extract, ethyl acetate, and n-butanol fractions of Aphloia theiformis (Vahl.) Benn. OBJECTIVE: To study the plausible binding modes of mangiferin to key enzymes linked to diabetes type 2 (DT2), obesity, hypertension, Alzheimer's disease, and urolithiasis using molecular docking. METHOD: Crystallographic structures of α-amylase, α-glucosidase, glycogen phosphorylase (GP), pancreatic lipase, cholesterol esterase (CEase), angiotensin-I-converting enzyme (ACE), acetyl cholinesterase (AChE), and urease available on the Protein Databank database were docked to mangiferin using Gold 6...
March 7, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28269787/cognitive-composites-domain-scores-related-to-neuroimaging-biomarkers-within-probable-amnestic-mild-cognitive-impairment-storage-subtype
#10
Ana Espinosa, Montserrat Alegret, Pedro Pesini, Sergi Valero, Asunción Lafuente, Mar Buendía, Itziar San José, Marta Ibarria, Miguel A Tejero, Joan Giménez, Susana Ruiz, Isabel Hernández, Francesc Pujadas, Pablo Martínez-Lage, Josep Munuera, Javier Arbizu, Lluis Tárraga, Suzanne B Hendrix, Agustín Ruiz, James T Becker, Susan M Landau, Oscar Sotolongo-Grau, Manuel Sarasa, Mercè Boada
The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222532/prevalence-of-use-of-cardiovascular-drugs-in-dementia-patients-treated-in-general-practices-in-germany
#11
Louis Jacob, Jens Bohlken, Karel Kostev
BACKGROUND: Dementia is a chronic disease associated with numerous cardiovascular disorders. OBJECTIVE: To analyze the prevalence of cardiovascular drug use in dementia patients treated in general practices in Germany. METHODS: The present study included patients who were diagnosed with dementia (Alzheimer's disease, vascular dementia, or unspecified dementia) in 2015. The main outcome measure was the proportion of patients using cardiovascular drugs...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28158298/administration-of-bovine-casein-derived-peptide-prevents-cognitive-decline-in-alzheimer-disease-model-mice
#12
Li-Juan Min, Yodai Kobayashi, Masaki Mogi, Kana Tsukuda, Akio Yamada, Koji Yamauchi, Fumiaki Abe, Jun Iwanami, Jin-Zhong Xiao, Masatsugu Horiuchi
There is a growing interest in identifying natural food ingredients that may serve to prevent dementia such as that due to Alzheimer disease (AD). Peptides derived from food proteins have been demonstrated to have various physiological activities such as a hypotensive action. Recent findings have indicated possible associations of hypertension with AD progression, and suggest that angiotensin converting enzyme (ACE) inhibitors with potential to pass through the blood brain barrier (BBB) may reduce the risk of AD...
2017: PloS One
https://www.readbyqxmd.com/read/28099631/associations-of-cerebrovascular-metabolism-genotypes-with-neuropsychiatric-symptoms-and-age-at-onset-of-alzheimer-s-disease-dementia
#13
Fabricio F de Oliveira, Elizabeth S Chen, Marilia C Smith, Paulo H Bertolucci
Objective: To study associations of cerebrovascular metabolism genotypes and haplotypes with age at Alzheimer's disease dementia (AD) onset and with neuropsychiatric symptoms according to each dementia stage. Methods: Consecutive outpatients with late-onset AD were assessed for age at dementia onset and Neuropsychiatric Inventory scores according to Clinical Dementia Rating scores, apolipoprotein E gene (APOE) haplotypes, angiotensin-converting enzyme gene (ACE) variants rs1800764 and rs4291, low-density lipoprotein cholesterol receptor gene (LDLR) variants rs11669576 and rs5930, cholesteryl ester transfer protein gene (CETP) variants I422V and TaqIB, and liver X receptor beta gene (NR1H2) polymorphism rs2695121...
April 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27905359/-clinical-and-neuropsychological-features-of-alzheimer-s-disease-in-the-combination-with-cerebrovascular-disease
#14
N A Trusova, O S Levin, A V Arablinsky
AIM: To study clinical/neuropsychological and neuroimaging characteristics of Alzheimer's disease in the combination with cerebrovascular disease (CVD). MATERIAL AND METHODS: Ninety patients with dementia, including 35 patients with AD, 35 patients with mixed dementia (MD) and 20 patients with vascular dementia, were examined. The character of dementia was established according to NINCDS-ADRDA and NINDS-AIREN criteria. The neuropsychological battery included Addenbrooke's Cognitive Examination (ACE-R), Montreal Cognitive Assessment scale (MoCA), fluency test and the visual memory test (SCT)...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27905355/-cerebral-microbleeds-in-cerebrovascular-and-neurodegenerative-diseases-with-cognitive-impairment
#15
T A Polyakova, O S Levin
AIM: To study a role of cerebral microbleeds (CMB) in the diagnosis of main cerebrovascular and neurodegenerative diseases with cognitive impairment. MATERIAL AND METHODS: CMB were studied in 120 patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB) and vascular dementia using 1.5T MRI in T2 * gradient echo. An impact of CMB on cognitive functions and the relationship with signs of vascular and neurodegenerative lesions of the brain were studied as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27884212/angiotensin-converting-enzyme-2-is-reduced-in-alzheimer-s-disease-in-association-with-increasing-amyloid-%C3%AE-and-tau-pathology
#16
Patrick Gavin Kehoe, Steffenny Wong, Noura Al Mulhim, Laura Elyse Palmer, J Scott Miners
BACKGROUND: Hyperactivity of the classical axis of the renin-angiotensin system (RAS), mediated by angiotensin II (Ang II) activation of the angiotensin II type 1 receptor (AT1R), is implicated in the pathogenesis of Alzheimer's disease (AD). Angiotensin-converting enzyme-2 (ACE-2) degrades Ang II to angiotensin 1-7 (Ang (1-7)) and counter-regulates the classical axis of RAS. We have investigated the expression and distribution of ACE-2 in post-mortem human brain tissue in relation to AD pathology and classical RAS axis activity...
November 25, 2016: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/27875990/inverse-relationship-between-alzheimer-s-disease-and-cancer-and-other-factors-contributing-to-alzheimer-s-disease-a-systematic-review
#17
REVIEW
Ovais Shafi
BACKGROUND: The AD etiology is yet not properly known. Interactions among environmental factors, multiple susceptibility genes and aging, contribute to AD. This study investigates the factors that play role in causing AD and how changes in cellular pathways contribute to AD. METHODS: PUBMED database, MEDLINE database and Google Scholar were searched with no date restrictions for published articles involving cellular pathways with roles in cancers, cell survival, growth, proliferation, development, aging, and also contributing to Alzheimer's disease...
November 22, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27862810/angiotensin-converting-enzyme-insertion-deletion-polymorphism-and-the-longitudinal-progression-of-alzheimer-s-disease
#18
Ping-Song Chou, Meng-Ni Wu, Mei-Chuan Chou, I Chien, Yuan-Han Yang
AIM: The angiotensin-converting enzyme gene (ACE) insertion (I)/deletion (D) polymorphism is considered a biologically plausible gene for Alzheimer's disease (AD) in cross-sectional studies. The present study aimed to investigate the longitudinal effect of ACE I/D polymorphism on AD progression. METHODS: This 3-year observational study investigated the longitudinal effect of ACE I/D polymorphism on AD progression. Clinically diagnosed AD patients with a clinical dementia rating (CDR) of 0...
November 10, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27763482/can-angiotensin-converting-enzyme-inhibitors-impact-cognitive-decline-in-early-stages-of-alzheimer-s-disease-an-overview-of-research-evidence-in-the-elderly-patient-population
#19
REVIEW
K Rygiel
Alzheimer's disease (AD) is a neurodegenerative disease, in which an accumulation of toxic amyloid beta in the brain precedes the emergence of clinical symptoms. AD spectrum consists of presymptomatic, early symptomatic, and symptomatic phase of dementia. At present, no pharmacotherapy exists to modify or reverse a course of AD, and only symptomatic treatments are available. Many elderly patients, diagnosed with multiple medical conditions (such as cardiovascular diseases, Type 2 diabetes mellitus, and cerebrovascular diseases) are at increased risk of the development of mild cognitive impairment (MCI), AD, and vascular dementia...
October 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/27754163/sy-11-3-hypertension-in-women-more-dangerous-than-in-men
#20
Suzanne Oparil
Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. In the US between 2011-2014, the prevalence of hypertension in women and men by age group was 6% vs 8% (18-39 years), 30% vs 35% (40-59 years), and 67% vs 63% (60 years and over). Awareness, treatment, and control rates differ between genders with women being more aware of their diagnosis (85% vs 80%), more likely to take their medications (81% vs 71%) and more frequently having controlled hypertension (55% vs 49%)...
September 2016: Journal of Hypertension
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