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https://www.readbyqxmd.com/read/29784417/the-use-of-la-icp-ms-databases-to-calculate-likelihood-ratios-for-the-forensic-analysis-of-glass-evidence
#1
Ruthmara Corzo, Tricia Hoffman, Peter Weis, Javier Franco-Pedroso, Daniel Ramos, Jose Almirall
Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry (LA-ICP-MS) has been shown to be an excellent technique for the discrimination of glass originating from different sources and for the association of glass originating from the same source. Typically, a match criterion is used to compare the elemental profile of the known sample to a questioned sample and if the glass samples are determined to "match" this may be followed by the use of a verbal scale to report the forensic practitioner's conclusion...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29746725/a-phase-i-single-ascending-dose-study-in-healthy-subjects-to-assess-the-safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-ds-2969b-a-novel-gyrb-inhibitor
#2
Justin Dennie, Alexander G Vandell, Satoshi Inoue, Roohi Gajee, Joseph Pav, George Zhang, Cynthia Zamora, Nobuhisa Masuda, Minoru Uchiyama, Makiko Yamada, Giorgio Senaldi
DS-2969b is a novel GyrB inhibitor in development for the treatment of Clostridium difficile infection. The aim of this study was to assess the safety, tolerability, pharmacokinetics, and effects on normal gastrointestinal microbiota groups of single daily oral ascending doses of DS-2969b in healthy subjects. The study enrolled 6 sequential ascending dose cohorts (6 mg, 20 mg, 60 mg, 200 mg, 400 mg, and 600 mg). In each cohort, 6 subjects were administered DS-2969b and 2 subjects were administered matching placebo...
May 10, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29735197/effect-of-parkinson-disease-on-emotion-perception-using-the-persian-affective-voices-test
#3
Arezoo Saffarian, Yunes Amiri Shavaki, Gholam Ali Shahidi, Zahra Jafari
BACKGROUND AND OBJECTIVES: Emotion perception plays a major role in proper communication with people in different social interactions. Nonverbal affect bursts can be used to evaluate vocal emotion perception. The present study was a preliminary step to establishing the psychometric properties of the Persian version of the Montreal Affective Voices (MAV) test, as well as to investigate the effect of Parkinson disease (PD) on vocal emotion perception. METHODS: The short, emotional sound made by pronouncing the vowel "a" in Persian was recorded by 22 actors and actresses to develop the Persian version of the MAV, the Persian Affective Voices (PAV), for emotions of happiness, sadness, pleasure, pain, anger, disgust, fear, surprise, and neutrality...
May 4, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29729219/finding-invisible-quantitative-trait-loci-with-missing-data
#4
Iulian Gabur, Harmeet Singh Chawla, Xiwei Liu, Vinod Kumar, Sébastien Faure, Andreas von Tiedemann, Christophe Jestin, Emmanuelle Dryzska, Susann Volkmann, Frank Breuer, Régine Delourme, Rod Snowdon, Christian Obermeier
Evolutionary processes during plant polyploidisation and speciation have led to extensive presence-absence variation (PAV) in crop genomes, and there is increasing evidence that PAV associates with important traits. Today, high-resolution genetic analysis in major crops frequently implements simple, cost-effective, high-throughput genotyping from single nucleotide polymorphism (SNP) hybridization arrays, however these are normally not designed to distinguish PAV from failed SNP calls caused by hybridization artefacts...
May 5, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29728052/a-new-method-for-the-assessment-of-endothelial-function-with-peripheral-arterial-volume
#5
Daoyuan Si, Lujia Ni, Yunfei Wang, Jinsha Liu, Jining Yang, Ping Yang
BACKGROUND: Currently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial function is still required. We evaluated the potential value of a new method to measure peripheral endothelial function with reactive hyperemia peripheral arterial volume (RH-PAV) in patients with chest pain. METHODS: We used a novel oximeter-like probe to detect the peripheral arterial volume (PAV) of the finger and compared it with brachial flow-mediated dilation (FMD) performed in 93 consecutive patients with chest pain...
May 4, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29724123/evidence-supporting-clinical-use-of-proportional-assist-ventilation-a-systematic-review-and-meta-analysis-of-clinical-trials
#6
Bharath Kumar Tirupakuzhi Vijayaraghavan, Shatha Hamed, Aditi Jain, Timothy Chimunda, Irene Telias, Jan O Friedrich, Karen E A Burns
BACKGROUND: While proportional assist ventilation (PAV), generates pressure in proportion to effort without a preselected target, proportional assist ventilation plus (PAV+) measures compliance and resistance, calculates work of breathing, and adjusts support to a preset assistance level. OBJECTIVE: To summarize randomized controlled trials (RCTs) comparing invasive or noninvasive PAV or PAV+ in critically ill patients. DATA SOURCES: We searched multiple databases to April 2017 without language restrictions and conference proceedings from 5 meetings to identify randomized parallel-group and crossover RCTs that compared invasive or noninvasive PAV or PAV+ to another mode in critically ill adults or children and reported at least 1 clinically important outcome...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29718680/evolution-of-frying-oil-quality-using-fourier-transform-near-infrared-ft-nir-spectroscopy
#7
Antonia M Calero, Estrella Muñoz, Dolores Pérez-Marin, Cecilia Riccioli, Luis Pérez, Ana Garrido-Varo
This study assesses the capacity of a Fourier transform near-infrared (FT-NIR) spectrometer operating in the range 4500-12 000 cm-1 (833.33-2222.22 nm) to provide quantitative predictions for the parameters of acidity (AV), p-anisidine (pAV), total polar materials (TPM), peroxide value (PV), and oxidative stability index (OSI). 562 samples of frying oil were analyzed from 14 distinct types of oil. The calibrations obtained accounted for 96%, 95%, 99%, 92%, and 91% of the AV, pAV, TPM, PV, and OSI variations in the study set and the similarity between the standard error of laboratory (RMSEP) values and the reference method errors (RMSEL), enabling the authors to conclude that NIR technology has the capacity to replace traditional methods in thermo-oxidative degradation studies in frying oils...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29718005/novel-sequences-structural-variations-and-gene-presence-variations-of-asian-cultivated-rice
#8
Zhiqiang Hu, Wensheng Wang, Zhichao Wu, Chen Sun, Min Li, Jinyuan Lu, Binying Fu, Jianxin Shi, Jianlong Xu, Jue Ruan, Chaochun Wei, Zhikang Li
Genomic diversity within a species genome is the genetic basis of its phenotypic diversity essential for its adaptation to environments. The big picture of the total genetic diversity within Asian cultivated rice has been uncovered since the sequencing of 3,000 rice genomes, including the SNP data publicly available in the SNP-Seek database. Here we report other aspects of the genetic diversity, including rice sequences assembled from over 3,000 accessions but absent in the Nipponbare reference genome, structural variations (SVs) and gene presence/absence variations (PAVs) in 453 accessions with sequencing depth over 20x...
May 2, 2018: Scientific Data
https://www.readbyqxmd.com/read/29703054/impact-of-von-willebrand-factor-on-coronary-plaque-burden-in-coronary-artery-disease-patients-treated-with-statins
#9
Yuta Kato, Atsushi Iwata, Makito Futami, Motoki Yamashita, Satoshi Imaizumi, Takashi Kuwano, Amane Ike, Makoto Sugihara, Hiroaki Nishikawa, Bo Zhang, Shin'ichiro Yasunaga, Keijiro Saku, Shin-Ichiro Miura
High von Willebrand factor (VWF) levels have been reported to be associated with an increased risk of cardiovascular events. However, the relationship between VWF levels and coronary atherosclerosis in patients with coronary artery disease (CAD) who have already received stain treatment is still unclear. We examined the association between VWF levels and coronary plaque as assessed by intravascular ultrasound (IVUS) in CAD patients treated with statins. Ninety-one CAD patients who underwent percutaneous coronary intervention under IVUS guidance, and who were already receiving statin treatment based on Japanese guidelines, were included...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29652758/is-inspiratory-muscle-weakness-a-determinant-of-endurance-exercise-tolerance-during-niv-supported-exercise-in-patients-with-copd
#10
Rodrigo Koch, Gabriel Victor Guimarães Rapello, Paulo de Tarso Müller
PURPOSE: Previous research has reported that inspiratory muscle weakness is critical to decreased exercise tolerance and exercise tolerance improves with 10 cmH2O pressure support ventilation in patients with chronic obstructive pulmonary disease (COPD). The purpose of this study was to evaluate the effects of proportional assist ventilation (PAV) and continuous positive airway pressure (CPAP) compared with sham on exercise tolerance in patients with and without inspiratory muscle weakness...
April 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29644558/finger-and-forehead-photoplethysmography-derived-pulse-pressure-variation-and-the-benefits-of-baseline-correction
#11
Shaoxiong Sun, Wouter H Peeters, Rick Bezemer, Xi Long, Igor Paulussen, Ronald M Aarts, Gerrit J Noordergraaf
To non-invasively predict fluid responsiveness, respiration-induced pulse amplitude variation (PAV) in the photoplethysmographic (PPG) signal has been proposed as an alternative to pulse pressure variation (PPV) in the arterial blood pressure (ABP) signal. However, it is still unclear how the performance of the PPG-derived PAV is site-dependent during surgery. The aim of this study is to compare finger- and forehead-PPG derived PAV in their ability to approach the value and trend of ABP-derived PPV. Furthermore, this study investigates four potential confounding factors, (1) baseline variation, (2) PPV, (3) ratio of respiration and heart rate, and (4) perfusion index, which might affect the agreement between PPV and PAV...
April 11, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29608694/scanpav-a-pipeline-for-extracting-presence-absence-variations-in-genome-pairs
#12
Francesca Giordano, Maximilian R Stammnitz, Elizabeth P Murchison, Zemin Ning
Motivation: The recent technological advances in genome sequencing techniques have resulted in an exponential increase in the number of sequenced human and non-human genomes. The ever increasing number of assemblies generated by novel de novo pipelines and strategies demands the development of new software to evaluate assembly quality and completeness. One way to determine the completeness of an assembly is by detecting its Presence-Absence variations (PAV) with respect to a reference, where PAVs between two assemblies are defined as the sequences present in one assembly but entirely missing in the other one...
March 28, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29601348/association-between-a-physical-activity-vital-sign-and-cardiometabolic-disease-in-high-risk-patients
#13
Vicki R Nelson, Robert V Masocol, Joseph A Ewing, Sheri Johnston, Allyson Hale, Michael Wiederman, Irfan M Asif
OBJECTIVE: To determine the association between the physical activity vital sign (PAVS) and markers of cardiometabolic disease. DESIGN: Patients were assessed through the PAVS, a validated tool self-reporting the frequency and duration of physical activity. Patients were categorized into 3 groups: inactive (0 minutes per week), underactive (1-149 minutes per week), and active (>150 minutes per week). Associations were tested between the PAVS and the cardiometabolic disease biomarkers of body mass index, hemoglobin A1c (A1c), blood pressure, and low-density lipoprotein (LDL) using one-way analyses of variance...
March 27, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29570813/in-vivo-biofilm-formation-gram-negative-infections-and-tas2r38-polymorphisms-in-crsw-np-patients
#14
Elena Cantone, Rossella Negri, Emanuela Roscetto, Rossella Grassia, Maria Rosaria Catania, Pasquale Capasso, Marianna Maffei, Amata Amy Soriano, Carlo Antonio Leone, Maurizio Iengo, Luigi Greco
OBJECTIVES: Among the predisposing factors implicated in the immune response to airway bacterial infections, genetic variations of the bitter taste receptor TAS2R38, which is expressed in the cilia of the human sinonasal epithelial cells, seem to be associated with susceptibility to chronic rhinosinusitis (CRS) and in vitro biofilm formation. Polymorphisms in TAS2R38 generate two common haplotypes: the nonfunctional AVI (Alanine, Valine, Isoleucine) and the functional PAV (Proline, Alanine, Valine) alleles, with the latter protecting against gram-negative sinonasal infections...
March 23, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29551724/the-effectiveness-of-salvage-treatments-for-recurrent-lesions-of-oligodendrogliomas-previously-treated-with-upfront-chemotherapy
#15
Daisuke Kuga, Nobuhiro Hata, Yojiro Akagi, Takeo Amemiya, Yuhei Sangatsuda, Ryusuke Hatae, Koji Yoshimoto, Masahiro Mizoguchi, Koji Iihara
BACKGROUND: We previously reported a favorable outcome in a case series of patients with oligodendrogliomas treated with upfront chemotherapy; however, their progression-free survival (PFS) was relatively short considering their long-term overall survival (OS). This suggests that salvage treatments after progression were effective. However, the clinical impact of salvage treatments on outcomes of patients with recurrent oligodendrogliomas has not been precisely investigated. METHODS: Our case series included 28 patients with newly diagnosed isocitrate dehydrogenase-mutant and 1p/19q-codeleted oligodendroglial tumors treated with upfront procarbazine, nimustine, and vincristine...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29548449/examination-of-marine-and-vegetable-oil-oxidation-data-from-a-multi-year-third-party-database
#16
Anna A De Boer, Adam Ismail, Keri Marshall, Gerard Bannenberg, Kevin L Yan, William J Rowe
Fish oil (FO) products constitute good sources of omega-3 fats. Oxidation data from a large third-party database of 1900 + globally-sourced FO samples were assessed. In FO products, for peroxide value (PV), 13.9% exceeded 5 mEq O2 /kg (2.2% >10); for acid value (AcV) 2.1% exceeded 3 mg KOH/g, while for p-anisidine value (pAV) in unflavoured oils, 6.1% exceeded 20, (3.8% >30), and 8.8% exceeded TOTOX limits (26). Additionally, we compared FO with other dietary oils. The FO median PV was similar to those of algal and sunflower oils, 4...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29527180/a-cross-sectional-analysis-of-students-intuitions-when-interpreting-cis
#17
Pav Kalinowski, Jerry Lai, Geoff Cumming
We explored how students interpret the relative likelihood of capturing a population parameter at various points of a CI in two studies. First, an online survey of 101 students found that students' beliefs about the probability curve within a CI take a variety of shapes, and that in fixed choice tasks, 39% CI [30, 48] of students' responses deviated from true distributions. For open ended tasks, this proportion rose to 85%, 95% CI [76, 90]. We interpret this as evidence that, for many students, intuitions about CIs distributions are ill-formed, and their responses are highly susceptible to question format...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29496901/evaluation-of-human-coronary-vasodilator-function-predicts-future-coronary-atheroma-progression
#18
Samuel L Sidharta, Timothy J Baillie, Stuart Howell, Stephen J Nicholls, Natalie Montarello, Satoshi Honda, Daisuke Shishikura, Sinny Delacroix, Susan Kim, John F Beltrame, Peter J Psaltis, Stephen G Worthley, Matthew I Worthley
OBJECTIVE: Coronary vasodilator function and atherosclerotic plaque progression have both been shown to be associated with adverse cardiovascular events. However, the relationship between these factors and the lipid burden of coronary plaque remains unknown. These experiments focus on investigating the relationship between impaired coronary vasodilator function (endothelium dependent (salbutamol) and endothelium independent (glyceryl trinitrate)) and the natural history of atheroma plaque progression and lipid burden using dual modality intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) imaging...
March 1, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29458319/proportional-assist-ventilation-versus-pressure-support-ventilation-in-weaning-ventilation-a-pilot-randomised-controlled-trial
#19
John Botha, Cameron Green, Ian Carney, Kavi Haji, Sachin Gupta, Ravindranath Tiruvoipati
OBJECTIVE: Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mode of ventilation that provides assistance in proportion to patient effort. This may have physiological and clinical advantages when compared with pressure support ventilation (PSV). Our objective was to compare these two modes in patients being weaned from mechanical ventilation. DESIGN: Prospective randomised controlled trial comparing PSV with PAV+. SETTING: University-affiliated, tertiary referral intensive care unit (ICU)...
March 2018: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/29446183/comparison-of-detergent-based-decellularization-protocols-for-the-removal-of-antigenic-cellular-components-in-porcine-aortic-valve
#20
Xiaohong Liu, Ning Li, Dejun Gong, Cuiping Xia, Zhiyun Xu
BACKGROUND: Various detergent-based protocols are used to remove cells and cellular debris in porcine aortic valve (PAV). However, the removal of antigenic cellular components has not been thoroughly elucidated to date. In this study, we used 4 detergent-based protocols to decellularize PAVs and aimed to evaluate their effects on removing antigenic cellular components. METHODS: Porcine aortic valves were decellularized using sodium dodecyl sulfate (SDS), SDS in combination with sodium deoxycholate (SDS/SD), Triton X-100, and Triton X-100 in combination with SD (Triton X-100/SD), respectively...
March 2018: Xenotransplantation
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