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Daisuke Kuga, Nobuhiro Hata, Yojiro Akagi, Takeo Amemiya, Yuhei Sangatsuda, Ryusuke Hatae, Koji Yoshimoto, Masahiro Mizoguchi, Koji Iihara
BACKGROUND: We previously reported a favorable outcome in a case series of patients with oligodendrogliomas treated with upfront chemotherapy; however, their progression free survival (PFS) was relatively short considering their long-term overall survival (OS). This suggests that salvage treatments after progression were effective. However, the clinical impact of salvage treatments on outcomes of patients with recurrent oligodendrogliomas has not been precisely investigated. METHODS: Our case series included 28 patients with newly diagnosed isocitrate dehydrogenase (IDH)-mutant and 1p/19q-codeleted oligodendroglial tumors treated with upfront procarbazine+nimustine+vincristine (PAV)...
March 15, 2018: World Neurosurgery
Anna A De Boer, Adam Ismail, Keri Marshall, Gerard Bannenberg, Kevin L Yan, William J Rowe
Fish oil (FO) products constitute good sources of omega-3 fats. Oxidation data from a large third-party database of 1900 + globally-sourced FO samples were assessed. In FO products, for peroxide value (PV), 13.9% exceeded 5 mEq O2 /kg (2.2% >10); for acid value (AcV) 2.1% exceeded 3 mg KOH/g, while for p-anisidine value (pAV) in unflavoured oils, 6.1% exceeded 20, (3.8% >30), and 8.8% exceeded TOTOX limits (26). Additionally, we compared FO with other dietary oils. The FO median PV was similar to those of algal and sunflower oils, 4...
July 15, 2018: Food Chemistry
Pav Kalinowski, Jerry Lai, Geoff Cumming
We explored how students interpret the relative likelihood of capturing a population parameter at various points of a CI in two studies. First, an online survey of 101 students found that students' beliefs about the probability curve within a CI take a variety of shapes, and that in fixed choice tasks, 39% CI [30, 48] of students' responses deviated from true distributions. For open ended tasks, this proportion rose to 85%, 95% CI [76, 90]. We interpret this as evidence that, for many students, intuitions about CIs distributions are ill-formed, and their responses are highly susceptible to question format...
2018: Frontiers in Psychology
Samuel L Sidharta, Timothy J Baillie, Stuart Howell, Stephen J Nicholls, Natalie Montarello, Satoshi Honda, Daisuke Shishikura, Sinny Delacroix, Susan Kim, John F Beltrame, Peter J Psaltis, Stephen G Worthley, Matthew I Worthley
OBJECTIVE: Coronary vasodilator function and atherosclerotic plaque progression have both been shown to be associated with adverse cardiovascular events. However, the relationship between these factors and the lipid burden of coronary plaque remains unknown. These experiments focus on investigating the relationship between impaired coronary vasodilator function (endothelium dependent (salbutamol) and endothelium independent (glyceryl trinitrate)) and the natural history of atheroma plaque progression and lipid burden using dual modality intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) imaging...
March 1, 2018: Heart: Official Journal of the British Cardiac Society
John Botha, Cameron Green, Ian Carney, Kavi Haji, Sachin Gupta, Ravindranath Tiruvoipati
OBJECTIVE: Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mode of ventilation that provides assistance in proportion to patient effort. This may have physiological and clinical advantages when compared with pressure support ventilation (PSV). Our objective was to compare these two modes in patients being weaned from mechanical ventilation. DESIGN: Prospective randomised controlled trial comparing PSV with PAV+. SETTING: University-affiliated, tertiary referral intensive care unit (ICU)...
March 2018: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
Xiaohong Liu, Ning Li, Dejun Gong, Cuiping Xia, Zhiyun Xu
BACKGROUND: Various detergent-based protocols are used to remove cells and cellular debris in porcine aortic valve (PAV). However, the removal of antigenic cellular components has not been thoroughly elucidated to date. In this study, we used 4 detergent-based protocols to decellularize PAVs and aimed to evaluate their effects on removing antigenic cellular components. METHODS: Porcine aortic valves were decellularized using sodium dodecyl sulfate (SDS), SDS in combination with sodium deoxycholate (SDS/SD), Triton X-100, and Triton X-100 in combination with SD (Triton X-100/SD), respectively...
February 15, 2018: Xenotransplantation
Alexander G Vandell, Satoshi Inoue, Justin Dennie, Yasuo Nagasawa, Roohi Gajee, Joe Pav, George Zhang, Cynthia Zamora, Nobuhisa Masuda, Giorgio Senaldi
DS-2969b is a novel GyrB inhibitor in development for the treatment of Clostridium difficile infection (CDI). The aim of this study was to assess the safety, tolerability, pharmacokinetics, and effects on normal gastrointestinal microbiota of multiple daily oral ascending doses of DS-2969b in healthy subjects. The study enrolled three sequential ascending dose cohorts (60 mg, 200 mg, and 400 mg). In each cohort, subjects received an oral dose of DS-2969b or placebo (six DS-2969b and two placebo) each morning for 14 days...
February 12, 2018: Antimicrobial Agents and Chemotherapy
Aude Darracq, Clémentine Vitte, Stéphane Nicolas, Jorge Duarte, Jean-Philippe Pichon, Tristan Mary-Huard, Céline Chevalier, Aurélie Bérard, Marie-Christine Le Paslier, Peter Rogowsky, Alain Charcosset, Johann Joets
BACKGROUND: Maize is well known for its exceptional structural diversity, including copy number variants (CNVs) and presence/absence variants (PAVs), and there is growing evidence for the role of structural variation in maize adaptation. While PAVs have been described in this important crop species, they have been only scarcely characterized at the sequence level and the extent of presence/absence variation and relative chromosomal landscape of inbred-specific regions remain to be elucidated...
February 5, 2018: BMC Genomics
Zhikun Li, Gengwu Li, Chao Chen, Yifan Li, Changwei Yang, Ming Li, Wei Xu, Xiaodong Zhu
Various parameters related to growth and maturity have been shown to be risk factors for scoliosis curve progression. We previously identified correlations between curve progression and radiographic parameters in clinical practice, but there is a lack of research.The aim of this study was to investigate and identify the radiographic parameters that are risk factors for rapid curve progression in Lenke 5 or 6 adolescent idiopathic scoliosis (AIS).A retrospective review of patients who were prospectively enrolled at the initiation of brace wear and followed through completion of bracing or surgery was performed...
December 2017: Medicine (Baltimore)
C M Wendl, M Aguilar Pérez, S Felber, C Stroszczynski, H Bäzner, H Henkes
The term "paraspinal arteriovenous shunts" (PAVS) summarizes an inhomogeneous variety of rare vascular disorders. PAVSs have been observed as congenital or acquired lesions. The clinical course of PAVSs may be asymptomatic or present with life threatening symptoms. Based on a collection of individual cases from three institutions and a literature evaluation, we propose the following classification: PAVSs that are part of a genetic syndrome are separated from "isolated" PAVSs. Isolated PAVSs are subdivided into "acquired", "traumatic" and "congenital" without an identifiable genetic hereditary disorder...
January 29, 2018: British Journal of Radiology
Mingmei Sun, Xiao Xu, Qiuqin Zhang, Xin Rui, Junjun Wu, Mingsheng Dong
Ultrasound-assisted aqueous extraction (UAAE) was used to extract oil from Clanis bilineata (CB), a traditional edible insect that can be reared on a large scale in China, and the physicochemical property and antioxidant capacity of the UAAE-derived oil (UAAEO) were investigated for the first time. UAAE conditions of CB oil was optimized using response surface methodology (RSM) and the highest oil yield (19.47%) was obtained under optimal conditions for ultrasonic power, extraction temperature, extraction time, and ultrasonic interval time at 400 W, 40℃, 50 min, and 2 s, respectively...
January 23, 2018: Journal of Oleo Science
Monal M Lal, Paul C Southgate, Dean R Jerry, Kyall R Zenger
Evolutionary relationships in the black-lip pearl oyster Pinctada margaritifera which is highly valued for pearl production remain poorly understood. This species possesses an 18,000 km Indo-Pacific natural distribution, and its current description includes six subspecies defined exclusively on morphological characters. To evaluate its taxonomic identity using molecular data, 14 populations in both the Indian and Pacific Oceans (n = 69), and the congeneric taxa P. maxima and P. mazatlanica (n = 29 and n = 10, respectively) were sampled...
January 9, 2018: Scientific Reports
Maria Pia Riccio, Chiara Franco, Rossella Negri, Roberta Ida Ferrentino, Roberta Maresca, Elisa D'alterio, Luigi Greco, Carmela Bravaccio
Several studies suggest that atypical eating behaviors, in particular food selectivity, are more frequent in children with autism spectrum disorder (ASD). A link between bitter taste perception, namely PROP/PTC sensitivity and food preferences is known in healthy children. The aim of this study is to investigate whether genetic variants of the TAS2R38 taste receptor responsible for different bitter sensitivity could affect foods preferences and consequently food refusal in ASD children. We recruited 43 children with ASD and 41 with normotypic development (TD) with or without food selectivity, aged between 2 and 11 years...
December 28, 2017: Autism Research: Official Journal of the International Society for Autism Research
José Mostacero León, Segundo E López Medina, Helmut Yabar, Jordan De La Cruz Castillo
Abstract: Peru is a megadiverse country with native species of all kinds, including dye plants, which have been used for hundreds of years by the local population. Despite the fact that many of these natural dyes are of a superior quality compared to synthetic ones and do not have the harmful effects that the latter may cause to human health, due to the lack of documentation and dissemination, ethnobotanical knowledge is unfortunately being lost with the passing of generations. In order to preserve and spread such valuable knowledge, this study conducted a comprehensive taxonomic, phytogeographic, and ethnobotanical inventory of dye plants based on periodical botanical explorations in selected locations of Northern Peru during the span of two decades...
December 18, 2017: Plants (Basel, Switzerland)
Davy Vancampfort, Michel Probst, David Basangwa, Marc De Hert, Inez Myin-Germeys, Ruud van Winkel, Philip B Ward, Simon Rosenbaum, James Mugisha
This study investigated cardio-metabolic risk factors among patients with severe mental illness who do or do not meet the recommendations of 150min per week of physical activity. A secondary aim was to assess whether those that do meet the recommendations report lower levels of mental health symptoms. 107 (60♀) Ugandan in- and outpatients (mean age=34.4 ± 9.7 years) with severe mental illness (depression=7, bipolar disorder=55, schizophrenia=45) completed the Physical Activity Vital Sign (PAVS) method and Brief Symptoms Inventory -18...
November 29, 2017: Psychiatry Research
Bhavna Hurgobin, Agnieszka A Golicz, Philipp E Bayer, Chon-Kit Kenneth Chan, Soodeh Tirnaz, Aria Dolatabadian, Sarah V Schiessl, Birgit Samans, Juan D Montenegro, Isobel A P Parkin, J Chris Pires, Boulos Chalhoub, Graham J King, Rod Snowdon, Jacqueline Batley, David Edwards
Homoeologous exchanges (HEs) have been shown to generate novel gene combinations and phenotypes in a range of polyploid species. Gene presence/absence variation (PAV) is also a major contributor to genetic diversity. In this study, we show that there is an association between these two events, particularly in recent Brassica napus synthetic accessions, and that these represent a novel source of genetic diversity, which can be captured for the improvement of this important crop species. By assembling the pangenome of B...
December 4, 2017: Plant Biotechnology Journal
Patricia Fuchs, Juliane Obermeier, Svend Kamysek, Martin Degner, Hannes Nierath, Henning Jürß, Hartmut Ewald, Jens Schwarz, Martin Becker, Jochen K Schubert
BACKGROUND: Contemporary resuscitation guidelines for basic life support recommend an immediate onset of cardiac compressions in case of cardiac arrest followed by rescue breaths. Effective ventilation is often omitted due to fear of doing harm and fear of infectious diseases. In order to improve ventilation a pre-stage of an automatic respirator was developed for use by laypersons. METHODS: Fifty-two healthy volunteers were ventilated by means of a prototype respirator via a full-face mask in a pilot study...
December 4, 2017: BMC Emergency Medicine
Yvonne M Golightly, Kelli D Allen, Kirsten R Ambrose, Jamie L Stiller, Kelly R Evenson, Christiane Voisin, Jennifer M Hootman, Leigh F Callahan
INTRODUCTION: Physical activity (PA) is strongly endorsed for managing chronic conditions, and a vital sign tool (indicator of general physical condition) could alert providers of inadequate PA to prompt counseling or referral. This systematic review examined the use, definitions, psychometric properties, and outcomes of brief PA instruments as vital sign measures, with attention primarily to studies focused on arthritis. METHODS: Electronic databases were searched for English-language literature from 1985 through 2016 using the terms PA, exercise, vital sign, exercise referral scheme, and exercise counseling...
November 30, 2017: Preventing Chronic Disease
Lauriane Serpa Silva Bosquiroli, Ana Caroline Dos Santos Ferreira, Katyuce Souza Farias, Eduarda Carneiro da Costa, Maria de Fátima Cepa Matos, Mônica Cristina Toffoli Kadri, Yasmin Silva Rizk, Flávio Macedo Alves, Renata Trentin Perdomo, Carlos Alexandre Carollo, Carla Cardozo Pinto de Arruda
CONTEXT: New antileishmanias are needed because of toxicity, high cost and resistance problems associated with available drugs. Nectandra (Lauraceae) produces several classes of compounds but its essential oil has not previously been reported to have antileishmania activity. OBJECTIVE: We evaluated the cytotoxicity and antileishmania activity of essential oils from Nectandra amazonum Nees, N. gardneri Meisn., N. hihua (Ruiz & Pav.) Rohwer and N. megapotamica (Spreng...
December 2017: Pharmaceutical Biology
Jiří Fukal, Ondřej Páv, Miloš Buděšínský, Jakub Šebera, Vladimír Sychrovský
A benchmark for structural interpretation of the31 P NMR shift and the2 JP,C NMR spin-spin coupling in the phosphate group was obtained by means of theoretical calculations and NMR measurements in diethylphosphate (DEP) and 5,5-dimethyl-2-hydroxy-1,3,2-dioxaphosphinane 2-oxide (cDEP). The NMR parameters were calculated employing the B3LYP, BP86, BPW91, M06-2X, PBE0, KT2, KT3, MP2, and HF methods, and the 6-31+G(d), Iglo-n (n = II, III), cc-pVnZ (n = D, T, Q, 5), aug-cc-pVnZ (n = D, T and Q), and pcS-n and pcJ-n (n = 1, 2, 3, 4) bases, including the solvent effects described with explicit water molecules and/or the implicit Polarizable Continuum Model (PCM)...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
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