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Gunnar BirgegÄrd
INTRODUCTION: Two factors have deeply influenced the area of essential thrombocythemia (ET). A gain-of-function mutation in the pseudokinase region of the JAK2 gene, which partly explains the pathophysiology of myeloproliferative neoplasms (MPNs), was discovered in 2005 and is present in 50 - 60% of ET patients. Furthermore, the 2008 WHO MPN classification outlined criteria for the separation of ET and early or prefibrotic primary myelofibrosis (PMF). However, these and other new findings have not yet changed the pharmacotherapy of ET, which is based on risk stratification for thrombohemorrhagic risk and aims to reduce thrombosis and bleeding...
July 2013: Expert Opinion on Pharmacotherapy
(no author information available yet)
No abstract text is available yet for this article.
January 2004: Journal of Supportive Oncology
J Becker
No abstract text is available yet for this article.
1972: Acta Chirurgica Scandinavica
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