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Photodynamic therapy cancer

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https://www.readbyqxmd.com/read/28545088/transcriptional-activation-of-hif-1-by-a-ros-erk-axis-underlies-the-resistance-to-photodynamic-therapy
#1
María Julia Lamberti, María Florencia Pansa, Renzo Emanuel Vera, Martín Ernesto Fernández-Zapico, Natalia Belén Rumie Vittar, Viviana Alicia Rivarola
Photodynamic therapy (PDT), a promising treatment option for cancer, involves the activation of a photosensitizer (PS) by local irradiation with visible light. Excitation of the PS leads to a series of photochemical reactions and consequently the local generation of harmful reactive oxygen species (ROS) causing limited or none systemic defects. However, the development of resistance to this promising therapy has slowed down its translation into the clinical practice. Thus, there is an increase need in understanding of the molecular mechanism underlying resistance to PDT...
2017: PloS One
https://www.readbyqxmd.com/read/28545086/cancer-cell-spheroids-are-a-better-screen-for-the-photodynamic-efficiency-of-glycosylated-photosensitizers
#2
Patrícia M R Pereira, Naxhije Berisha, N V S Dinesh K Bhupathiraju, Rosa Fernandes, João P C Tomé, Charles Michael Drain
Photodynamic Therapy (PDT) relies on the use of non-toxic photosensitizers that are locally and selectively activated by light to induce cell death or apoptosis through reactive oxygen species generation. The conjugation of porphyrinoids with sugars that target cancer is increasingly viewed as an effective way to increase the selectivity of PDT. To date, in vitro PDT efficacy is mostly screened using two-dimensional monolayer cultures. Compared to monolayer cultures, three-dimensional spheroid cultures have unique spatial distributions of nutrients, metabolites, oxygen and signalling molecules; therefore better mimic in vivo conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28544068/interstitial-fluid-pressure-a-novel-biomarker-to-monitor-photo-induced-drug-uptake-in-tumor-and-normal-tissues
#3
Sabrina Cavin, Xingyu Wang, Matthieu Zellweger, Michel Gonzalez, Michaël Bensimon, Georges Wagnières, Thorsten Krueger, Hans-Beat Ris, Fabrizio Gronchi, Jean Y Perentes
BACKGROUND: Low-dose photodynamic therapy PDT (photoinduction) can modulate tumor vessels and enhance the uptake of liposomal cisplatin (Lipoplatin®) in pleural malignancies. However, the photo-induction conditions must be tightly controlled as overtreatment shuts down tumor vessels and enhances normal tissue drug uptake. MATERIAL AND METHODS: In a pleural sarcoma and adenocarcinoma rat model (n = 12/group), we applied photoinduction (0.0625 mg/kg Visudyne®, 10 J/cm(2) ) followed by intravenous Lipoplatin® (5 mg/kg) administration...
May 22, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28541049/synthesis-and-photophysical-and-photocatalytic-properties-of-a-highly-fluorinated-and-durable-phthalocyanine-peptide-bioconjugate-for-potential-theranostic-applications
#4
Erik N Carrión, Jenyffer Santiago, David Sabatino, Sergiu M Gorun
The functionalized, asymmetric fluoro-fluoroalkyl scaffold F48H7COOHPcZn (3) was used to prepare F48H7COOPcZn-6-amino-hexanoate-CTVALPGGYVRVC (5), a Pep42 peptide bioconjugate envisioned for photodynamic therapy, which can specifically target the GRP78 chaperone protein overexpressed and exclusively localized on some cancer cell surfaces. The analogous F48H7COOHPcCu (4) has also been prepared, and its single-crystal X-ray structure was elucidated. Despite reduced steric hindrance relative to the nonfunctionalized, single-site complexes of the F64Pc scaffold, no aggregation was detected in solution via UV-vis spectroscopy, for either 3, 4, or 5, consistent with the lack of π stacking observed for the crystalline 4...
May 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28537894/intratumoral-depletion-of-regulatory-t-cells-using-cd25-targeted-photodynamic-therapy-in-a-mouse-melanoma-model-induces-antitumoral-immune-responses
#5
Dong Sun Oh, Heegon Kim, Ji Eun Oh, Hi Eun Jung, Yun Soo Lee, Ji-Ho Park, Heung Kyu Lee
Tumor immunotherapy aims to overcome the immunosuppressive microenvironment within tumors, and various approaches have been developed. Tumor-associated T regulatory cells (Tregs) suppress the activation and expansion of tumor antigen-specific effector T cells, thus, providing a permissive environment for tumor growth. Therefore, optimal strategies need to be established to deplete tumor-infiltrated Tregs because systemic depletion of Tregs can result in reduced anti-tumor effector cells and autoimmunity. Here, to selectively deplete Tregs in tumors, we intratumorally injected anti-CD25 antibodies conjugated to Chlorin e6 (Ce6), a photosensitizer that absorbs light to generate reactive oxygen species...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28537714/enhanced-afterglow-performance-of-persistent-luminescence-implants-for-efficient-repeatable-photodynamic-therapy
#6
Wenpei Fan, Nan Lu, Can Xu, Yijing Liu, Jing Lin, Sheng Wang, Zheyu Shen, Zhen Yang, Junle Qu, Tianfu Wang, Siping Chen, Peng Huang, Xiaoyuan Chen
Persistent luminescence nanoparticles (PLNPs) have been used for bioimaging without autofluorescence background interference, but the poor afterglow performance impedes their further applications in cancer therapy. To overcome the Achilles' heel of PLNPs, herein we report the construction of injectable persistent luminescence implants (denoted as PL implants) as a built-in excitation source for efficient repeatable photodynamic therapy (PDT). The injectable ZGC (ZnGa1.996O4:Cr0.004) PL implants were prepared by dissolving ZGC PLNPs in poly(lactic-co-glycolic acid)/N-methylpyrrolidone oleosol, which demonstrated much stronger persistent luminescence (PersL) intensity and longer PersL lifetime than that of ZGC PLNPs both in vitro and in vivo...
May 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28534823/preparation-and-in-vitro-photodynamic-activity-of-glucosylated-zinc-ii-phthalocyanines-as-underlying-targeting-photosensitizers
#7
Jian-Yong Liu, Chen Wang, Chun-Hui Zhu, Zhi-Hong Zhang, Jin-Ping Xue
Two novel glucosylated zinc(ІІ) phthalocyanines 7a-7b, as well as the acetyl-protected counterparts 6a-6b, have been synthesized by the Cu(I)-catalyzed 1,3-dipolar cycloaddition between the propargylated phthalocyanine and azide-substituted glucoses. All of these phthalocyanines were characterized with various spectroscopic methods and studied for their photo-physical, photo-chemical, and photo-biological properties. With glucose as the targeting unit, phthalocyanines 7a-7b exhibit a specific affinity to MCF-7 breast cancer cells over human embryonic lung fibroblast (HELF) cells, showing higher cellular uptake...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28529636/a-new-green-titania-with-enhanced-nir-absorption-for-mitochondria-targeted-cancer-therapy
#8
Juan Mou, Tianquan Lin, Fuqiang Huang, Jianlin Shi, Hangrong Chen
A new kind of green titania (G-TiO2-x ) with obvious green color was facilely synthesized from black titania (B-TiO2-x ) through subsequently strong ultrasonication. Comparatively, this stable G-TiO2-x shows much enhanced near infrared (NIR) absorption, especially around 920 nm, which can be ascribed to the obvious change of TiO2-x lattice order owing to the effect of ultrasonication. This feature enables G-TiO2-x to be stimulated with 980 nm laser in the combined photodynamic therapy (PDT) and photothermal therapy (PTT), which is greatly beneficial for improving tissue penetration depth...
2017: Theranostics
https://www.readbyqxmd.com/read/28528604/a-multicenter-clinical-study-of-expected-and-unexpected-side-reactions-during-and-after-skin-cancer-treatment-by-photodynamic-therapy
#9
Kate C Blanco, Natalia M Inada, Ana P Silva, Mirian D Stringasci, Hilde H Buzzá, Dora P Ramirez, Ana G Sálvio, Lilian T Moriyama, Cristina Kurachi, Vanderlei S Bagnato
Photodynamic therapy (PDT) has been widely used for oncologic indications, especially nonmelanoma skin cancer such as superficial and nodular basal cell carcinoma (BCC). We present a multicenter clinical study conducted between 2012 and 2014 analyzing the adverse reactions during and after PDT with a standardized protocol in 866 lesions. A total of 728 patients with positive clinical and histopathological diagnosis for BCC with up to 2 cm diameter were treated. The procedure consisted of curettage and topical application of cream containing 20% methyl 5-aminolevulinate...
2017: Skinmed
https://www.readbyqxmd.com/read/28524186/taurine-modified-ru-ii-complex-targets-cancerous-brain-cells-for-photodynamic-therapy
#10
Enming Du, Xunwu Hu, Sona Roy, Peng Wang, Kieran Deasy, Toshiaki Mochizuki, Ye Zhang
The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species...
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28523110/photodynamic-activities-of-porphyrin-derivative-cyclodextrin-complexes-by-photoirradiation
#11
Atsushi Ikeda, Shuhei Satake, Tomoya Mae, Masafumi Ueda, Kouta Sugikawa, Hajime Shigeto, Hisakage Funabashi, Akio Kuroda
Water-soluble cyclodextrin (CyD) complexed with porphyrin derivatives with different substituents in the meso-positions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer...
May 11, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28522192/overcoming-photodynamic-resistance-and-tumor-targeting-dual-therapy-mediated-by-indocyanine-green-conjugated-gold-nanospheres
#12
Wei Li, Xiaomeng Guo, Fenfen Kong, Hanbo Zhang, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Yongzhong Du, Jian You
Photodynamic therapy (PDT) and photothermal therapy (PTT) have captured much attention due to the great potential to cure malignant tumor. Nevertheless, photodynamic resistance of cancer cells has limited the further efficacy of PDT. Unfortunately, the resistance mechanism and efforts to overcome the resistance still have been rarely reported so far. Here, we report a nanosystem with specific tumor targeting for combined PDT and PTT mediated by near-infrared (NIR) light, which was established by covalently conjugating indocyanine green (ICG) and TNYL peptide onto the surface of hollow gold nanospheres (HAuNS)...
May 15, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28521449/the-effect-of-aloe-emodin-induced-photodynamic-activity-on-the-apoptosis-of-human-gastric-cancer-cells-a-pilot-study
#13
Hai-Dan Lin, Kai-Ting Li, Qin-Qin Duan, Qing Chen, Shi Tian, Ellie Shihng Meir Chu, Ding-Qun Bai
The aim of the present study was to explore the effect of aloe-emodin (AE)-induced photodynamic activity in human gastric cancer cells. AE was used as a photosensitizer to explore the effect of photodynamic therapy (PDT) in human gastric cancer cells (SGC-7901). An MTT assay was used to detect the effect of AE-induced PDT in optimal concentrations and illumination energy densities in human gastric cancer cells. Following AE-induced PDT, morphological changes of the cells and the rate of cell death were evaluated by TUNEL assay and flow cytometry, respectively...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28516508/near-infrared-photodynamic-inactivation-of-s-pneumoniae-and-its-interaction-with-raw-264-7-macrophages
#14
Ilaiáli S Leite, Mariana C Geralde, Ana C G Salina, Alexandra I Medeiros, Lívia N Dovigo, Vanderlei S Bagnato, Natalia M Inada
Pneumonia is the main cause of children mortality worldwide, and its major treatment obstacle stems from the microorganisms increasing development of resistance to several antibiotics. Photodynamic therapy has been presenting, for the last decades, promising results for some subtypes of cancer and infections. In this work we aimed to develop a safe and efficient in vitro protocol for photodynamic inactivation of Streptococcus pneumoniae, one of the most commonly found bacteria in pneumonia cases, using two near-infrared light sources and indocyanine green, a FDA approved dye...
May 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28511619/daylight-photodynamic-therapy-in-scotland
#15
Helen Cordey, Ronan Valentine, Andrea Lesar, Harry Moseley, Ewan Eadie, Sally Ibbotson
Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people in Scotland. These changes are a major cause of morbidity and may develop into skin cancer. Actinic keratoses are often extensive and pose a therapeutic challenge as field-directed treatment is required for chronic disease management. One such treatment approach is hospital-based photodynamic therapy, which is a well-established treatment in Scotland for actinic keratoses, using a photosensitiser pro-drug and red LED light irradiation...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28510089/porphyrin-based-cationic-amphiphilic-photosensitisers-as-potential-anticancer-antimicrobial-and-immunosuppressive-agents
#16
REVIEW
Nela Malatesti, Ivana Munitic, Igor Jurak
Photodynamic therapy (PDT) combines a photosensitiser, light and molecular oxygen to induce oxidative stress that can be used to kill pathogens, cancer cells and other highly proliferative cells. There is a growing number of clinically approved photosensitisers and applications of PDT, whose main advantages include the possibility of selective targeting, localised action and stimulation of the immune responses. Further improvements and broader use of PDT could be accomplished by designing new photosensitisers with increased selectivity and bioavailability...
April 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28509917/effect-of-mthpc-mediated-photodynamic-therapy-on-5-fluorouracil-resistant-human-colorectal-cancer-cells
#17
E Kukcinaviciute, A Sasnauskiene, D Dabkeviciene, V Kirveliene, V Jonusiene
The primary or acquired cancer chemoresistance is a major problem in the treatment of cancer patients. It could be overcome by non-overlapping treatment regimens such as photodynamic therapy (PDT). PDT is based on the oxidation of cellular components which occurs when a light-excited photosensitizer generates reactive oxygen species (ROS). In this study the effect of mTHPC mediated PDT (mTHPC-PDT) on 5-FU resistant colorectal cancer (CRC) cells HCT116 was investigated. The results show that mTHPC-PDT overcomes 5-FU resistance and is effective against chemoresistant colorectal carcinoma cells...
May 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28509858/modes-of-cell-death-induced-by-photodynamic-therapy-using-zinc-phthalocyanine-in-lung-cancer-cells-grown-as-a-monolayer-and-three-dimensional-multicellular-spheroids
#18
Sello L Manoto, Nicolette Houreld, Natasha Hodgkinson, Heidi Abrahamse
Photodynamic therapy (PDT) involves interaction of a photosensitizer, light, and molecular oxygen which produces singlet oxygen and subsequent tumour eradication. The development of second generation photosensitizers, such as phthalocyanines, has improved this technology. Customary monolayer cell culture techniques are, unfortunately, too simple to replicate treatment effects in vivo. Multicellular tumour spheroids may provide a better alternative since they mimic aspects of the human tumour environment. This study aimed to profile 84 genes involved in apoptosis following treatment with PDT on lung cancer cells (A549) grown in a monolayer versus three-dimensional multicellular tumour spheroids (250 and 500 μm)...
May 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28509427/self-supplying-o2-through-the-catalase-like-activity-of-gold-nanoclusters-for-photodynamic-therapy-against-hypoxic-cancer-cells
#19
Ching-Ping Liu, Te-Haw Wu, Chia-Yeh Liu, Kuan-Chung Chen, Yu-Xing Chen, Gin-Shin Chen, Shu-Yi Lin
Photodynamic therapy (PDT) typically involves oxygen (O2 ) consumption and therefore suffers from greatly limited anticancer therapeutic efficacy in tumor hypoxia. Here, it is reported for the first time that amine-terminated, PAMAM dendrimer-encapsulated gold nanoclusters (AuNCs-NH2 ) can produce O2 for PDT via their intrinsic catalase-like activity. The AuNCs-NH2 not only show optimum H2 O2 consumption via the catalase-like activity over the physiological pH range (i.e., pH 4.8-7.4), but also extend such activity to acidic conditions...
May 16, 2017: Small
https://www.readbyqxmd.com/read/28509422/evaluation-of-the-medicinal-potential-of-two-ruthenium-ii-polypyridine-complexes-as-one-and-two-photon-photodynamic-therapy-photosensitizers
#20
Jeannine Hess, Huaiyi Huang, Adrian Kaiser, Vanessa Pierroz, Olivier Blacque, Hui Chao, Gilles Gasser
Two [Ru(phen)2dppz]2+ derivatives (phen = 1,10-phenantroline, dppz = dipyrido[3,2-a:2',3'-c]phenazine) with different functional groups on the dppz ligand [dppz-7,8-(OMe)2 (1), dppz-7,8-(OH)2 (2)] have been synthesized, characterized and investigated as photosensitizers (PSs) for photodynamic therapy (PDT) against cancer. Both complexes showed intense red phosphorescence and promising singlet oxygen (1O2) quantum yields of 75 % (1) and 54 % (2), respectively, in acetonitrile. 1 (logPo/w = -0.52, 2.4 nmol Ru per mg protein) was found to be more lipophilic, having also a higher cellular uptake efficiency compared to 2 (logPo/w = -0...
May 16, 2017: Chemistry: a European Journal
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