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Photodynamic therapy cancer

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https://www.readbyqxmd.com/read/28926732/multifunctional-mesoporous-zro2-encapsulated-upconversion-nanoparticles-for-mild-nir-light-activated-synergistic-cancer-therapy
#1
Lili Feng, Shili Gai, Fei He, Yunlu Dai, Chongna Zhong, Piaoping Yang, Jun Lin
Desirable nanosystem that could not only deliver drugs safely and effectively into tumor sites, but also be expected to serve as photosensitizer to realize the photodynamic therapeutic function, would be of great significance in the synergistic cancer therapy. To perform this task, a multifunctional nanosystem has been developed for markedly enhanced cancer therapeutic efficacy by loading chemotherapy agent (doxorubicin hydrochloride, DOX) and photosensitive drug chlorin e6 (Ce6) into the channels of mesoporous zirconium dioxide (ZrO2) layer which coats on Nd(3+)-doped upconversion nanoparticles (UCNPs)...
September 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28923402/synergistic-chemo-photodynamic-therapy-by-big-small-combo-nanoparticles-sequential-release-system
#2
Li Fan, Saisai Zhao, Xin Jin, Yongsheng Zhang, Chaojun Song, Hong Wu
Chemo-photodynamic combination has been manifested great potential for synergistic cancer therapy. Moreover, the synergistic efficacy could be significantly enhanced by well designed sequential release manner of photosensitizers (PSs). Here we propose a "Big & small combo nanoparticles (NPbig&small)" system for double loading PSs methylene blue (MB) and single absorbing chemotherapeutics drug Gemcitabine hydrochloride (GM(.)HCl). The "grown-in" MB from NPbig&small show two-peak sequential release profile, significantly improve the absorbed chemo therapeutic efficacy of GM(...
September 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28919756/polymeric-mixed-micelles-loaded-mitoxantrone-for-overcoming-multidrug-resistance-in-breast-cancer-via-photodynamic-therapy
#3
Zeyong Li, Yuee Cai, Yiqiao Zhao, Hua Yu, Haiyu Zhou, Meiwan Chen
Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(d,l-lactide-co-glycolide)-poly(ethylene glycol)-poly(d,l-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28918670/ph-sensitive-metal-phenolic-network-capsules-for-targeted-photodynamic-therapy-against-cancer-cells
#4
Yuanqing Wei, Zhenzhen Wei, Peicheng Luo, Wei Wei, Songqin Liu
Photodynamic therapy (PDT) is an effective and promising method for cancer treatment, which is proposed for more than one century. However, the specific delivery of photosensitizer to target carcinoma cells to reduce the side effect is still a great challenge. This work provides a strategy to deliver photosensitizers to cancer cells by utilizing pH-sensitive polyethylene glycol metal-phenolic network (PEG-MPN) capsules to encapsulate haematoporphyrin monomethyl ether (HMME). With the assistance of folic acid (FA), HMME-doped PEG-MPN capsules (MPN@HMMEs) accumulate in carcinoma cells selectively followed by releasing HMME in the lysosomes because of the physiologically relevant acidic pH environment...
September 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28918177/photodynamic-therapy-in-oral-potentially-malignant-disorders-critical-literature-review-of-existing-protocols
#5
REVIEW
Jéssica Araújo Figueira, Vanessa Cristina Veltrini
INTRODUCTION: Oral cancer is a serious public health issue. Apart from its high rate of prevalence, incidence and mortality, it can often result in more complex and expensive treatment when diagnosed late. Potentially malignant disorders (PMDs) can precede oral cancer, and are usually treated by surgical excision. However, in many cases patients are elderly and multiple interventions may be required. Photodynamic therapy (PDT) is a simple alternative, which has been successfully used in the treatment of oral PMDs...
September 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28916141/in-vivo-multimodal-tumor-imaging-and-photodynamic-therapy-with-novel-theranostic-agents-based-on-the-porphyrazine-framework-chelated-gadolinium-iii-cation
#6
Diana V Yuzhakova, Svetlana A Lermontova, Ilya S Grigoryev, Maria S Muravieva, Alena I Gavrina, Marina V Shirmanova, Irina V Balalaeva, Larisa G Klapshina, Elena V Zagaynova
BACKGROUND: A promising strategy for cancer diagnosis and therapy is the development of an agent for multimodal imaging and treatment. In the present paper we report on two novel multifunctional agents prepared on the porphyrazine pigment platform using a gadolinium (III) cation chelated by red-fluorescent tetrapyrrole macrocycles (GdPz1 and GdPz2). METHODS: Spectral and magnetic properties of the compounds were analyzed. Monitoring of GdPz1 and GdPz2 accumulation in the murine colon carcinoma CT26 was performed in vivo using fluorescence imaging and MRI...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28914009/luminescent-diagnostics-of-skin-defects-in-the-near-infrared-range
#7
Yuriy V Alekseev, Valentina D Rumyantseva, Anastasiya S Gorshkova, Anastasiya E Shchelkunova, Igor P Shilov, Andrey V Ivanov
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28913666/quantitative-modeling-of-the-dynamics-and-intracellular-trafficking-of-far-red-light-activatable-prodrugs-implications-in-stimuli-responsive-drug-delivery-system
#8
Mengjie Li, Pritam Thapa, Pallavi Rajaputra, Moses Bio, Cody J Peer, William D Figg, Youngjae You, Sukyung Woo
The combination of photodynamic therapy (PDT) with anti-tumor agents is a complimentary strategy to treat local cancers. We developed a unique photosensitizer (PS)-conjugated paclitaxel (PTX) prodrug in which a PS is excited by near-infrared wavelength light to site-specifically release PTX while generating singlet oxygen (SO) to effectively kill cancer cells with both PTX and SO. The aim of the present study was to identify the determinants influencing the combined efficacy of this light-activatable prodrug, especially the bystander killing effects from released PTX...
September 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28910739/novel-ruthenium-azo-quinoline-complexes-with-enhanced-photonuclease-activity-in-human-cancer-cells
#9
Mangesh H Kaulage, Basudeb Maji, Sanjeev Pasadi, Santanu Bhattacharya, K Muniyappa
Coordinatively saturated ruthenium complexes with a variable net charge are currently under intense investigation for their anticancer potential. These complexes, possessing long wavelength metal-to-ligand charge transfer with DNA photonuclease activity, have shown promising cytotoxic profiles. Although most of the ruthenium complexes exhibit significant photochemotherapeutic activity, their poor entry into cells hinder their development as potential drug molecules. Here, we report the synthesis and characterization of four new ruthenium (II) azo-8-hydroxyquinoline complexes, their mode of in vitro DNA binding and antiproliferative properties against cultured human cancer cell lines...
August 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28901740/inhibiting-metastasis-and-preventing-tumor-relapse-by-triggering-host-immunity-with-tumor-targeted-photodynamic-therapy-using-photosensitizer-loaded-functional-nanographenes
#10
Xinhe Yu, Duo Gao, Liquan Gao, Jianhao Lai, Chenran Zhang, Yang Zhao, Lijun Zhong, Bing Jia, Fan Wang, Xiaoyuan Chen, Zhaofei Liu
Effective cancer therapy depends not only on destroying the primary tumor but also on conditioning the host immune system to recognize and eliminate residual tumor cells and prevent metastasis. In this study, a tumor integrin αvβ6-targeting peptide (the HK peptide)-functionalized graphene oxide (GO) was coated with a photosensitizer (HPPH). The resulting GO conjugate, GO(HPPH)-PEG-HK, was investigated whether it could destroy primary tumors and boost host antitumor immunity. We found that GO(HPPH)-PEG-HK exhibited significantly higher tumor uptake than GO(HPPH)-PEG and HPPH...
September 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/28899098/heterodimers-made-of-upconversion-nanoparticles-and-metal-organic-frameworks
#11
Yifan Li, Zhenghan Di, Jinghong Gao, Ping Cheng, Chunzhi Di, Ge Zhang, Bei Liu, Xinghua Shi, Lingdong Sun, Lele Li, Chun-Hua Yan
Creating nanoparticle dimers has attracted extensive interest. However, it still remains a great challenge to synthesize heterodimers with asymmetric compositions and synergistically enhanced functions. In this work, we report the synthesis of high quality heterodimers composed of porphyrinic nanoscale metal-organic frameworks (nMOF) and lanthanide-doped upconversion nanoparticles (UCNPs). Due to the dual optical properties inherited from individual nanoparticles and their interactions, absorption of low energy photons by the UCNPs is followed by energy transfer to the nMOFs, which then undergo activation of porphyrins to generate singlet oxygen...
September 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28895715/a-pompon-like-runps-based-theranostic-nanocarrier-system-with-stable-photoacoustic-imaging-characteristic-for-accurate-tumor-detection-and-efficient-phototherapy-guidance
#12
Gengjia Chen, Meng Xu, Shuang Zhao, Jing Sun, Qianqian Yu, Jie Liu
Even though numerous therapeutic methods exist for cancer treatment, many fail to achieve ideal outcomes or have severe side effects. Here, we describe a theranostic nanocarrier system with improved tumor vasculature detection and tumor margin quantification that increases the accuracy and guidance efficiency of phototherapy. Novel pompon-like RuNPs with superb photothermal properties and high encapsulation efficiency were first synthesized via the polyol reducing method. Based on these RuNPs, we then developed a multifunctional theranostic system, pRu-pNIPAM@RBT, composed of poly(Nisopropylacrylamide) as the thermal-response switch and of [Ru(bpy)2(tip)]2+ as the photosensitizer of PDT and the contrast agent of biomedical imaging...
September 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28892021/near-infrared-triggered-photodynamic-therapy-toward-breast-cancer-cells-using-dendrimer-functionalized-upconversion-nanoparticles
#13
Bing-Yen Wang, Ming-Liang Liao, Guan-Ci Hong, Wen-Wei Chang, Chih-Chien Chu
Water-soluble upconversion nanoparticles (UCNPs) that exhibit significant ultraviolet, blue, and red emissions under 980-nm laser excitation were successfully synthesized for performing near infrared (NIR)-triggered photodynamic therapy (PDT). The lanthanide-doped UCNPs bearing oleate ligands were first exchanged by citrates to generate polyanionic surfaces and then sequentially encapsulated with NH₂-terminated poly(amido amine) (PAMAM) dendrimers (G4) and chlorine6 (Ce6) using a layer-by-layer (LBL) absorption strategy...
September 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28890844/evaluation-of-silicon-phthalocyanine-4-photodynamic-therapy-against-human-cervical-cancer-cells-in-vitro-and-in-mice
#14
Jill A Gadzinski, Jianxia Guo, Brian J Philips, Per Basse, Ethan K Craig, Lisa Bailey, John T Comerci, Julie L Eiseman
BACKGROUND: Cervical cancer is the second most common cancer in women worldwide [1]. Photodynamic therapy has been used for cervical intraepithelial neoplasia with good responses, but few studies have used newer phototherapeutics. We evaluated the effectiveness of photodynamic therapy using Pc 4 in vitro and in vivo against human cervical cancer cells. METHODS: CaSki and ME-180 cancer cells were grown as monolayers and spheroids. Cell growth and cytotoxicity were measured using a methylthiazol tetrazolium assay...
December 2016: Advances in Biological Chemistry
https://www.readbyqxmd.com/read/28890213/oxygen-generating-nanoparticles-for-improved-photodynamic-therapy-of-hypoxic-tumours
#15
Yingjie Sheng, Heather Nesbitt, Bridgeen Callan, Mark A Taylor, Mark Love, Anthony P McHale, John F Callan
Photodynamic therapy (PDT) is a clinically approved anti-cancer treatment that involves the activation of an otherwise inactive sensitiser drug with light, which in the presence of molecular oxygen, generates cytotoxic reactive oxygen species (ROS). As oxygen is a key requirement for the generation of ROS in PDT and given the fact that hypoxia is a characteristic of most solid cancerous tumours, treating hypoxic tumours using PDT can be a challenge. In this manuscript, we have prepared a CaO2 nanoparticle (NP) formulation coated with a pH-sensitive polymer to enable the controlled generation of molecular oxygen as a function of pH...
September 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28890210/photodynamic-therapy-an-option-in-mycosis-fungoides
#16
Pileri Alessandro, Sgubbi Paola, Agostinelli Claudio, Infusino Salvatore Domenico, Vaccari Sabina, Patrizi Annalisa
BACKGROUND: Photodynamic therapy (PDT) is a well-known and effective treatment for non-melanoma skin-cancer. Numerous studies have also shown its effectiveness in mycosis fungoides. The aim of the study was to analyse MF patients treated with PDT at the Dermatology Unit of Bologna University. METHODS: We retrospectively analysed MF patients treated with PDT over the last ten years. Each PDT protocol consisted of the appliance for 3h under an occlusive film dressing on each lesion of a one-mm-thick layer of 16% methyl aminolaevulinate (MAL) 160mg/g cream (Metvix(®), Galderma, Paris, France)...
September 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28888976/simple-nanophotosensitizer-fabrication-using-water-soluble-chitosan-for-photodynamic-therapy-in-gastrointestinal-cancer-cells
#17
Young-Il Jeong, Byungyoul Cha, Hye Lim Lee, Yeon Hui Song, Yun Hye Jung, Tae Won Kwak, Changyong Choi, Gyeong-Won Jeong, Jae Woon Nah, Dae Hwan Kang
The polysaccharide chitosan has abundant cationic amine groups, and can form ion-complexes with anionic molecules such as the strong photosensitizer chlorin e6 (Ce6). In this study, water-soluble chitosan (WSC) was used to fabricate Ce6-incorporated nanophotosensitizers (Abbreviated as ChitoCe6 nanophotosensitizer) via a self-assembling process. This was accomplished by dissolving WSC in pure water and then directly mixing the solution with solid Ce6 causing ion complex formation between WSC and Ce6. The resulting nanophotosensitizer was spherical in shape and had a particle size of less than 300nm...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28886209/treatment-of-superficial-basal-cell-carcinoma-by-topical-photodynamic-therapy-with-fractionated-5-aminolevulinic-acid-20-versus-two-stage-topical-methylaminolevulinic-acid-results-of-a-randomized-controlled-trial
#18
J P H M Kessels, H Kreukels, P J Nelemans, M H Roozeboom, H van Pelt, K Mosterd, E R M de Haas, N W J Kelleners-Smeets
BACKGROUND: Basal cell carcinoma (BCC) is the most common type of skin cancer with growing incidence rates. Photodynamic therapy (PDT) is a frequently used treatment, especially for superficial BCC (sBCC). Two topical photosensitizing agents are currently used to treat sBCC: 5-aminolevulinic acid (ALA) and its methyl-ester (MAL). Previous research showed a high efficacy of ALA-PDT using a 2-fold fractionated illumination scheme in which two light fractions of 20 and 80 J/cm2 are delivered, four and six hours after ALA application...
September 8, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28883725/gold-nanoparticles-enlighten-the-future-of-cancer-theranostics
#19
REVIEW
Jianfeng Guo, Kamil Rahme, Yan He, Lin-Lin Li, Justin D Holmes, Caitriona M O'Driscoll
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bio-imaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed "theranostics," multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28881432/protein-4-1r-is-involved-in-the-transport-of-5-aminolevulinic-acid-by-interaction-with-gats-in-mef-cells
#20
Shuwei Ning, Qiaozhen Kang, Dandan Fan, Jingjing Liu, Chaoyue Xue, Xiaolin Zhang, Cong Ding, Jianying Zhang, Qian Peng, Zhenyu Ji
5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) has been successfully used in the treatment of cancers. However, the mechanism of 5-ALA transportation into cancer cells is still not fully elucidated. Previous studies have confirmed that the efficiency of 5-ALA-PDT could be affected by the membrane skeleton protein 4.1R. In this study we investigated the role of 4.1R in the transport of 5-ALA into cells. Wild-type (4.1R(+/+) ) and 4.1R gene knockout (4.1R(-/-) ) mouse embryonic fibroblast (MEF) cells were incubated with 1 mM 5-ALA and different concentrations of specific inhibitors of GABA transporters GAT(1-3)...
September 7, 2017: Photochemistry and Photobiology
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