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Photodynamic therapy cancer

Lina A Al-Ani, Mohammed A AlSaadi, Farkaad A Kadir, Najihah M Hashim, Nurhidayatullaili M Julkapli, Wageeh A Yehye
Early detection and efficient treatment of cancer disease remains a drastic challenge in 21st century. Throughout the bulk of funds, studies, and current therapeutics, cancer seems to aggressively advance with drug resistance strains and recurrence rates. Nevertheless, nanotechnologies have indeed given hope to be the next generation for oncology applications. According to US National cancer institute, it is anticipated to revolutionize the perspectives of cancer diagnosis and therapy. With such success, nano-hybrid strategy creates a marvelous preference...
July 28, 2017: European Journal of Medicinal Chemistry
Uwe Reinhold
BF-200 ALA is a combination of a nanoscale-lipid vesicle formulation and the prodrug 5-aminolevulinic acid (5-ALA). The nanoemulsion stabilizes the prodrug and enhances its penetration through the stratum corneum. It has shown excellent therapeutic results in both lesion and field-directed photodynamic therapy of actinic keratosis (AK). AK is an early form of epidermal neoplasia and a precursor of invasive cutaneous squamous cell carcinoma. It is characterized by the combination of visible neoplastic lesions and surrounding tissue also harboring tumorigenic UV-induced mutations: a concept called field cancerization...
August 14, 2017: Future Oncology
Guangxu Lan, Kaiyuan Ni, Ruoyu Xu, Kuangda Lu, Zekai Lin, Christina Chan, Wenbin Lin
We report the rational design of metal-organic layers (MOLs) that are built from [Hf6O4(OH)4(HCO2)6] secondary building units (SBUs) and Ir[bpy(ppy)2]+- or Ru(bpy)32+-derived tricarboxylate ligands (Hf-BPY-Ir or Hf-BPY-Ru; bpy = 2,2'-bipyridine, ppy = 2-phenyl-pyridine) and their applications in deeply penetrating X-ray induced photodynamic therapy (X-PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X-rays and transfer energy to Ir[bpy(ppy)2]+ or Ru(bpy)32+ moieties to induce PDT by generating reactive oxygen species (ROS)...
August 13, 2017: Angewandte Chemie
Ke Li, Ling Qiu, Qingzhu Liu, Gaochao Lv, Xueyu Zhao, Shanshan Wang, Jianguo Lin
In order to improve the efficacy of photodynamic therapy (PDT), biotin was axially conjugated with silicon(IV) phthalocyanine (SiPc) skeleton to develop a new tumor-targeting photosensitizer SiPc-biotin. The target compound SiPc-biotin showed much higher binding affinity toward BR-positive (biotin receptor overexpressed) HeLa human cervical carcinoma cells than its precursor SiPc-pip. However, when the biotin receptors of HeLa cells were blocked by free biotin, >50% uptake of SiPc-biotin was suppressed, demonstrating that SiPc-biotin could selectively accumulate in BR-positive cancer cells via the BR-mediated internalization...
August 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
Zhiying Feng, Peng Tao, Liang Zou, Pengli Gao, Yuan Liu, Xing Liu, Hua Wang, Shujuan Liu, Qingchen Dong, Jie Li, Bingshe Xu, Wei Huang, Raymond Wai Yeung Wong, Qiang Zhao
Real-time monitoring the contents of molecular oxygen (O2) in tumor cells is of great significance in early diagnosis of cancer. At the same time, the photodynamic therapy (PDT) could be realized by highly toxic singlet oxygen (1O2) generated in situ during the O2 sensing, making it one of the most promising methods for cancer therapy. Herein, the iridium(III) complex cored hyper-branched phosphorescent conjugated polymer dots with the negative charges for hypoxia imaging and highly efficient PDT was rationally designed and synthesized...
August 10, 2017: ACS Applied Materials & Interfaces
Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Ji Yun Jeong, Yong-Deok Lee, Mi-Hwa Choi, Sehoon Kim, Ji-Young Park, Jin Hyang Jung
PURPOSE: Minimally invasive treatments for early breast cancer have been reported. The objective of this study was to evaluate and compare two such treatments, laser ablation and photodynamic therapy (PDT), regarding their therapeutic efficacy for breast cancer. METHODS: Breast tumors were induced in 12 mice models. The treatment options were classified into four groups: control group (without any treatment, A), group treated only with laser ablation (B), group treated only with PDT (C), and group treated with the combination of laser ablation followed by PDT (D)...
August 8, 2017: Photomedicine and Laser Surgery
Ahmad Al-Moujahed, Katarzyna Brodowska, Tomasz P Stryjewski, Nikolaos E Efstathiou, Ioannis Vasilikos, Joanna Cichy, Joan W Miller, Evangelos Gragoudas, Demetrios G Vavvas
Verteporfin (VP), a light-activated drug used in photodynamic therapy for the treatment of choroidal neovascular membranes, has also been shown to be an effective inhibitor of malignant cells. Recently, studies have demonstrated that, even without photo-activation, VP may still inhibit certain tumor cell lines, including ovarian cancer, hepatocarcinoma and retinoblastoma, through the inhibition of the YAP-TEAD complex. In this study, we examined the effects of VP without light activation on human glioma cell lines (LN229 and SNB19)...
August 8, 2017: Scientific Reports
Weiting Chen, Huijuan Zhao, Tongxin Li, Panpan Yan, Kuanxin Zhao, Caixia Qi, Feng Gao
BACKGROUND: Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeutic responses during photodynamic therapy of skin diseases. The conventional SFD measurement requires a reference measurement within the same experimental scenario as that for a test one to calibrate mismatch between the real measurements and the model predictions. Due to the individual physical and geometrical differences among different tissues, organs and patients, an ideal reference measurement might be unavailable in clinical trials...
August 8, 2017: Biomedical Engineering Online
Juan-Juan Chen, Yi-Zhen Huang, Mei-Ru Song, Zhi-Hong Zhang, Jin-Ping Xue
Small molecular target-based photodynamic therapy-a promising targeted anticancer strategy-has been developed by the conjugation between zinc (II) phthalocyanine and small molecular target-based anticancer drug. To inhibit the self-aggregation and avoid the isomeride problem of phthalocyanine, two silicon phthalocyanines di-substituted axially with erlotinib have been synthesized and fully characterized. These conjugates exist as a monomeric form in different solvents and the culture media. Cellular experiments showed that these conjugates localize in lysosomes and mitochondria, and keep high photodynamic activities (IC₅₀ is as low as 8 nM under 1...
August 4, 2017: ChemMedChem
A B Veloso, J P F Longo, L A Muehlmann, B F Tollstadius, P E N Souza, R B Azevedo, P C Morais, S W da Silva
In this study Surface Enhanced Raman Spectroscopy (SERS) data recorded from mouse mammary glands cancer cells (4T1 cell line) was used to assess information regarding differences between control, death and viable cells after Photodynamic Therapy (PDT) treatment. The treatment used nanoemulsions (NE/PS) loaded with different chloroaluminumphthalocyanine (ClAlP) photosensitizer (PS) contents (5 and 10 µmol × L(-1)) and illumination (660 nm wavelength) at 10 J × cm(-2) (10 minutes). The SERS data revealed significant molecular alterations in proteins and lipids due to the PDT treatment...
August 3, 2017: Scientific Reports
Jean-François Longevial, Khaled El Cheikh, Dina Aggad, Aurélien Lebrun, Arie van der Lee, Frederik Tielens, Sébastien Clément, Alain Morère, Marcel Garcia, Magali Gary-Bobo, Sébastien Richeter
Porphyrins fused to imidazolium salts across two neighboring beta-pyrrolic positions were used as N-heterocyclic carbene (NHC) precursors to anchor Au(I)-Cl complexes at their periphery. Then, synthesis of several thiolato-Au(I) complexes was achieved by substituting chloride by thiolates. Photodynamic properties of these complexes were investigated; the data obtained show that the Au-S bonds could be cleaved upon irradiation. The proposed mechanism to explain the release of thiolate moiety involves the S atom oxidation by singlet oxygen generated in the course of irradiation...
August 1, 2017: Chemistry: a European Journal
Carl J Fisher, Carolyn Niu, Warren Foltz, Yonghong Chen, Elena Sidorova-Darmos, James H Eubanks, Lothar Lilge
BACKGROUND: Malignant gliomas are highly invasive, difficult to treat, and account for 2% of cancer deaths worldwide. Glioblastoma Multiforme (GBM) comprises the most common and aggressive intracranial tumor. The study hypothesis is to investigate the modification of Photodynamic Therapy (PDT) efficacy by mild hypothermia leads to increased glioma cell kill while protecting normal neuronal structures. METHODS: Photosensitizer accumulation and PDT efficacy in vitro were quantified in various glioma cell lines, primary rat neurons, and astrocytes...
2017: PloS One
Moumita Gangopadhyay, Rakesh Mengji, Amrita Paul, Yarra Venkatesh, Venugopal Vangala, Avijit Jana, N D Pradeep Singh
A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The "locked" FRET pair was selectively "unlocked" by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.
July 31, 2017: Chemical Communications: Chem Comm
Jian Yin, Quan Zhang, Ying Cai, Qiu-Yan Li, Lin-Na Hao, Zheng Ma, Xiao-Jun Wang
The targeted delivery of a photosensitizer (PS) with appropriate carriers represents an attractive means of selectively delivering cargo to target tissues or subcellular compartments for photodynamic therapy (PDT). Herein, we report a three-arm distyryl BODIPY derivative conjugated with mannose units (denoted by BTM) that can co-assemble with Tween 80 to form nanomicelles (BTM-NMs) for targeted PDT. MDA-MB-231 breast cancer cells recognized and specifically internalized BTM-NMs via mannose receptor-mediated endocytosis with preferential accumulation in the lysosomes...
July 28, 2017: Chemistry: a European Journal
Liu Xingang, W U Min, L I Suying, Li Zhongbao, H U Qinglian, Zhou Jun, Tang Guping
Objective: To design and synthesize photosensitizers with different substituents and to identify its physicochemical characteritics and photodynamic effect on cancer cells. Methods: Two kinds of BODIPY photosensitizers BPOI and BPCI were synthesized through condensation reaction between aldehyde and reactive hydrogen of pyrrole, followed with electrophilic substitution reaction. Physicochemical properties were characterized by (1)H NMR, FT-IR and UV-visible absorption spectra and fluorescence emission spectra...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
Dan Wang, Lin Zhu, Yuan Pu, Jie-Xin Wang, Jian-Feng Chen, Liming Dai
In the present study, we devised a green-synthesis route to NaYF4:Gd(3+),Yb(3+),Er(3+) upconversion nanoparticles (UCNPs) by using eco-friendly paraffin liquid, instead of 1-octadecene, as a high boiling non-coordinating solvent. A multifunctional nanoplatform was then developed by coating UCNPs with biocompatible transferrin (TRF) for magnetically-assisted and near-infrared light induced photodynamic therapy and bioimaging. Protoporphyrin IX (PpIX), a clinically approved photodynamic therapy agent, was loaded into the shell layer of the TRF-coated UCNPs (UCNP@TRF nanoparticles), which can be efficiently taken up by cancer cells for photodynamic therapy...
July 28, 2017: Nanoscale
Chun-Gang Min, Paulo J O Ferreira, Luís Pinto da Silva
Coelenterazine is a widespread bioluminescent substrate for a diverse set of marine species. Moreover, its imidazopyrazinone core is present in eight phyla of bioluminescent organisms. Given their very attractive intrinsic properties, these bioluminescent systems have been used in bioimaging, photodynamic therapy of cancer, as gene reporter and in sensing applications, among others. While it is known that bioluminescence results from the thermolysis of high-energy dioxetanones, the mechanism and dioxetanone species responsible for the singlet chemiexcitation of Coelenterazine are not fully understood...
July 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
Shawn Swavey, Krista Morford, Max Tsao, Kristen Comfort, Mary Kate Kilroy
A heteroleptic monometallic ruthenium(II) and a heteroleptic trimetallic ruthenium(II) complex have been synthesized and characterized. Both complexes have an overall 3+ charge, with the charge density greater for the monometallic complex. The electronic spectra of the monometallic ruthenium(II) complex exhibits intense π-π* transitions associated with the bipyridyl groups along with overlapping metal to ligand charge transfer (MLCT) and ligand centered π-π* transitions ranging from 520nm to approximately 600nm...
July 18, 2017: Journal of Inorganic Biochemistry
Xiang Huijing, Hongzhong Chen, Huijun Phoebe Tham, Soo Zeng Fiona Phua, Jin-Gang Liu, Yanli Zhao
The integration of chemotherapy and photodynamic therapy (PDT) in a single delivery system is highly desirable for enhancing anticancer therapeutic efficacy. Herein, two cyclometalated Ir(III) complex-constructed micelles FIr-1 and FIr-2 were demonstrated for glutathione (GSH) activated targeted chemotherapy and PDT. The cyclometalated Ir(III) complexes were prepared by conjugating phosphorescent Ir(III) compounds with chemotherapeutic drug camptothecin (CPT) through GSH responsive disulfide bond linkages, and the Ir(III) complexes were then assembled with amphiphilic surfactant pluronic F127 via noncovalent encapsulation to afford micelles...
July 27, 2017: ACS Applied Materials & Interfaces
Vusala Ibrahimova, Sergey A Denisov, Kevin Vanvarenberg, Peter Verwilst, Véronique Préat, Jean-Michel Guigner, Nathan D McClenaghan, Sébastien Lecommandoux, Charles-André Fustin
Localization of the photosensitizer conjugation site in amphiphilic block copolymers is shown to have a great impact on photodynamic therapy efficiency. To this end, an asymmetric multifunctional derivative of the azadipyrromethene boron difluoride chelate (aza-BODIPY) was synthesized and inserted at specific locations in polypeptide-based rod-coil amphiphilic block copolymers. A study of the photophysical properties of the vesicle nanocarriers, obtained by self-assembly of these copolymers, as well as in vitro tests on two cancer cell lines were performed...
July 27, 2017: Nanoscale
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