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Photodynamic therapy cancer

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https://www.readbyqxmd.com/read/28098886/novel-zinc-phthalocyanine-as-a-promising-photosensitizer-for-photodynamic-treatment-of-esophageal-cancer
#1
Weronika Kuzyniak, Jacob Schmidt, Wojciech Glac, Janine Berkholz, Gustav Steinemann, Björn Hoffmann, Eugeny A Ermilov, Ayşe Gül Gürek, Vefa Ahsen, Bianca Nitzsche, Michael Höpfner
Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal cancer therapy. However, there is a constant need for improving the effectiveness and tolerability of the applied photosensitizers (PS). Here, we propose tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) as a promising PS for photodynamic treatment of esophageal cancer. ZnPc-induced phototoxicity was studied in two human esophageal cancer cell lines: OE-33 (adenocarcinoma) and Kyse-140 (squamous cell carcinoma)...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28097863/mitochondria-targeted-protein-ruthenium-photosensitizer-for-efficient-photodynamic-applications
#2
Sabyasachi Chakrabortty, Bikram Keshari Agrawalla, Anne Stumper, Naidu M Vegi, Stephan Fischer, Christian Reichardt, Michael Kögler, Benjamin Dietzek, Michaela Feuring-Buske, Christian Buske, Sven Rau, Tanja Weil
Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity towards several cancerous cell lines. In particu-lar, enhanced anti-cancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs...
January 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#3
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095542/the-two-faces-of-fractionated-photodynamic-therapy-increasing-efficacy-with-light-fractionation-or-adjuvant-use-of-fractional-laser-technology
#4
Margit L W Juhasz, Melissa K Levin, Ellen S Marmur
"Fractionated photodynamic therapy (PDT)" is a new term being used by dermatologists to describe advances in PDT technology including fractionated light or the adjuvant use of fractional lasers. Although dermatologists have used PDT since the early 1990s for the treatment of photodamage and precancerous lesions, newer developments in technology have allowed for the treatment of non-melanoma skin cancers (NMSCs), in ammatory disorders, and even uses in the eld of anti-aging. Recent developments in fractionated light therapy have allowed for PDT with dark intervals and two-fold illumination schemes to increase cellular damage and apoptosis...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28090694/graphene-oxide-wrapped-sio2-tio2-hollow-nanoparticles-loaded-with-photosensitizer-for-photothermal-and-photodynamic-combination-therapy
#5
Yoonsun Jang, Sojin Kim, Seungae Lee, Chang-Min Yoon, Inkyu Lee, Jyongsik Jang
Graphene oxide (GO) enwrapped SiO2/TiO2 hollow nanoparticles (GO-HNP) are synthesized by stöbber method and used as a nanocarrier for loading protoporphyrin IX (PpIX). The synthesized nanoparticle has high dispersibitliy and high uniformity in diameter (ca. 50 nm). . Furthermore, this nanoparticle shows 808 nm laser induced PpIX release property (photo-induced "on-off" drug release system). The GO-HNP-PpIX is employed for inducing both photothermal therapy (PTT) and photodynamic therapy (PDT). The synergic effect of the PTT and PDT exhibits powerful anti-cancer property...
January 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28089923/nursing-care-management-of-photodynamic-therapy-in-digestive-tract-carcinomas-at-a-single-cancer-center
#6
Atsushi Nanashima, Koji Nakashima, Hiroshi Kawakami, Shinya Ashizuka, Yoshimasa Kubota
The primary goal of nursing care in cases of endoscopic photodynamic therapy (PDT) for digestive tract carcinoma is to prevent phototoxicity by the intravenous administration of photosensitizers. The adequate protocol and management of patients should be conducted under the instruction of expert physicians. Our experiences of administering porfimer sodium and talaporfin sodium during clinical PDT provide insight regarding the specific management protocol of each photosensitizer during an in-hospital stay. We herein report our nursing protocol based on 15 years of experience...
January 9, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28088891/recent-advances-in-developing-photosensitizers-for-photodynamic-cancer-therapy
#7
Cong Chen, Jianmin Wang, Xiaoyan Li, Xiaolong Liu, Xiao Han
Photosensitizers are key molecules used in photodynamic cancer therapy (PDT), which is an effective therapeutic modality option for several diseases and non-oncological disorders. Due to its lower systemic toxicity and its ability to destroy tumors selectively, PDT has been considered clinical avenue for the treatment of several cancers. Three essential elements are involved in a PDT procedure: a photosensitizer, light of a specific wavelength, and singlet oxygen. However, the properties of conventional photosensitizers exhibit some drawbacks that may limit their use...
January 13, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28088105/tectona-grandis-leaf-extract-free-and-associated-with-nanoemulsions-as-a-possible-photosensitizer-of-mouse-melanoma-b16-cell
#8
Cydia de Menezes Furtado, Fernando Sergio Escocio Drumond Viana de Faria, Ricardo Bentes Azevedo, Karen Py-Daniel, Ana Lygia Dos Santos Camara, Jaqueline Rodriguez da Silva, Everton de Holanda Oliveira, Anselmo Fortunato Ruiz Rodriguez, Igor Anatolievich Degterev
Over the past six years we have been studying extracts from tropical, specially Amazon, plants, to search for new sensitizers for photodynamic therapy of cancer and infectious diseases. Tectona grandis is a genus of tropical hardwood trees in the mint family, Lamiaceae. That is native to south and southeast Asia, but since the end of the 20th century is also gaining ground in the Amazon. The present work aims to evaluate the photodynamic potential of hydro-alcoholic extract from Tectona grandis LF leaves (TGE) and the same extract prepared as the oil-water nanoemulsion (TGE-NE) against melanoma B16 F10 cells...
January 5, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28087479/synthesis-and-characterization-of-gold-nanostructured-chorin-e6-for-photodynamic-therapy
#9
L Vieira, M L Castilho, I Ferreira, J Ferreira-Strixino, K C Hewitt, L Raniero
Photodynamic therapy is an alternative treatment for cancer based on cellular uptake of a photosensitizer, illuminated with an appropriate wavelength in the presence of oxygen. A cascade of reactions generates reactive oxygen species leading to cell death. Using carbodiimide chemistry, chlorin e6 (Ce6) was covalently bonded to thiourea, and (via the sulphur end group) to gold nanoparticles (AuNPs), forming the Ce6-AuNP complex. Ce6 absorbs in the range 650-680nm, where the coefficient of biological tissue absorption is low (part of the therapeutic window), which is ideal for biological application...
January 10, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28087376/ir780-loaded-tpgs-tos-micelles-for-breast-cancer-photodynamic-therapy
#10
Cleide Pais-Silva, Duarte de Melo-Diogo, Ilídio J Correia
IR780 iodide is a near-infrared (NIR) dye with a huge potential for cancer imaging and phototherapy. However, its biomedical application is strongly impaired by its lipophilic character. Herein, amphiphilic micelles based on d-α-tocopheryl polyethylene glycol succinate (TPGS) and d-α-tocopheryl succinate (TOS), two vitamin E derivatives with intrinsic anticancer activity, are explored to load IR780. IR780-loaded micelles with suitable sizes are obtained by using specific TPGS and TOS weight feed ratios during micelles formulation and these are able to encapsulate IR780 with high efficiency...
January 11, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28075057/two-dimensional-nanomaterials-for-cancer-nanotheranostics
#11
Yongjiu Chen, Yakun Wu, Bingbing Sun, Sijin Liu, Huiyu Liu
Emerging nanotechnologies show unprecedented advantages in accelerating cancer theranostics. Among them, two-dimensional nanomaterials (2DNMs) represent a novel type of material with versatile physicochemical properties that have enabled a new horizon for applications in both cancer diagnosis and therapy. Studies have demonstrated that 2DNMs may be used in diverse aspects, including i) cancer detection due to their high propensity towards tumor markers; ii) molecular imaging for guided tumor therapies, and iii) drug and gene loading, photothermal and photodynamic cancer therapies...
January 11, 2017: Small
https://www.readbyqxmd.com/read/28072485/water-soluble-polymer-nanoparticles-constructed-by-three-component-self-assembly-an-efficient-theranostic-agent-for-phosphorescent-imaging-and-photodynamic-therapy
#12
Qi Yang, Min Shi, Heng Zhao, Jiaomin Lin, Lu An, Lili Cui, Hong Yang, Zhiguo Zhou, Qiwei Tian, Shiping Yang
Water soluble polymer nanoparticles (NP-1 and NP-2) were prepared by three-component self-assembly of iridium complex, poly(4-vinyl pyridine-b-ethylene oxide) (P4VP-b-PEO), and methane sulfonic acid (MSA). Due to the unique metal-ligand charge transfer transition property and heavy atom effect of iridium, NP-1 and NP-2 showed bright phosphorescence and generated singlet oxygen (1O2) effectively under visible light irradiation (λ > 400 nm) with a power density of 300 mW/cm2. NP-2, an example of polymer nanoparticles, showed minimal cytotoxic activity in the dark...
January 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28072400/prostate-cancer-light-camera-action-photodynamic-therapy-for-low-risk-disease
#13
Louise Stone
No abstract text is available yet for this article.
January 10, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28070573/nanoparticle-delivery-of-wnt-1-sirna-enhances-photodynamic-therapy-by-inhibiting-epithelial-mesenchymal-transition-for-oral-cancer
#14
Chuan Ma, Leilei Shi, Yu Huang, Lingyue Shen, Hao Peng, Xinyuan Zhu, Guoyu Zhou
Activation of the epithelial to mesenchymal transition (EMT) in photodynamic therapy (PDT) can lead to the recurrence and progression of tumors. To enhance the effects of PDT, it is essential to inhibit the Wnt/β-catenin signaling pathway involved in EMT progression. Herein, we used polyethylene glycol-polyethyleneimine-chlorin e6 (PEG-PEI-Ce6) nanoparticles to efficiently deliver Wnt-1 small interfering RNA (siRNA) to the cytoplasm of KB cells (oral squamous cell carcinoma) that were subjected to PDT. Wnt-1 siRNA effectively inhibited the Wnt/β-catenin signaling pathway, reducing the expression of Wnt-1, β-catenin and vimentin that are crucial to the EMT...
January 10, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28070104/comparative-photodynamic-therapy-cytotoxicity-of-mannose-conjugated-chlorin-and-talaporfin-sodium-in-cultured-human-and-rat-cells
#15
Yo Shinoda, Tsutomu Takahashi, Jiro Akimoto, Megumi Ichikawa, Hiromi Yamazaki, Atsushi Narumi, Shigenobu Yano, Yasuyuki Fujiwara
Photodynamic therapy (PDT) is a Food and Drug Administration authorized method for cancer treatment, which uses photosensitizer and laser photo-irradiation to generate reactive oxygen species to induce cell death in tumors. Photosensitizers have been progressively developed, from first to third generation, with improvements in cell specificity, reduced side effects and toxicity, increased sensitivity for irradiation and reduced persistence of photosensitizer in healthy cells. These improvements have been achieved by basic comparative experiments between current and novel photosensitizers using cell lines; however, photosensitizers should be carefully evaluated because they may have cell type specificity...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28068066/gold-nanospheres-stabilized-indocyanine-green-as-a-synchronous-photodynamic-photothermal-therapy-platform-that-inhibits-tumor-growth-and-metastasis
#16
Wei Li, Hanbo Zhang, Xiaomeng Guo, Zuhua Wang, Fenfen Kong, Lihua Luo, Qingpo Li, Chunqi Zhu, Jie Yang, Yan Lou, Yong-Zhong Du, Jian You
Both photothermal therapy (PTT) and photodynamic therapy (PDT) are phototherapeutic approaches, which have been widely investigated for cancer therapy mediated by external light source. Here, a nanosystem presenting synchronous PTT and PDT effect realized through one-step near infrared (NIR) light irradiation is reported. This system was fabricated by conjugating indocyanine green (ICG) on hollow gold nanospheres (HAuNS) using branched-polyethylenimine (PEI, MW=10 kDa) as optimal linker, which provided a high ICG payload as well as a covering layer with suitable thickness on HAuNS to maintain ICG fluorescence and reactive oxygen species (ROS) productivity...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28067928/near-infrared-light-mediated-enhancement-of-reactive-oxygen-species-generation-through-electron-transfer-from-graphene-oxide-to-iron-hydroxide-oxide
#17
Yue He, Andrea Del Valle, Yu Qian, Yu-Fen Huang
Clinical applications of current photodynamic therapy (PDT) agents are often restricted to be activated only by UV and visible light, which have very poor tissue penetration depths. In this study, a new near infrared (NIR)-absorbing nanoagent based on graphene oxide decorated with iron hydroxide/oxide (GO-FeOxH) was developed for light-activated nanomaterial-mediated PDT. This nanocomposite, GO-FeOxH was prepared via the one-step electrooxidation of iron nails in an aqueous GO solution. The as-prepared GO-FeOxH showed a much higher reactive oxygen species (ROS) activity under NIR light irradiation than GO...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28067798/dark-and-photoinduced-cytotoxic-activity-of-the-new-chlorophyll-a-derivatives-with-oligoethylene-glycol-substituents-on-the-periphery-of-their-macrocycles
#18
Yana I Pylina, Dmitry M Shadrin, Oksana G Shevchenko, Olga M Startseva, Igor O Velegzhaninov, Dmitry V Belykh, Ilya O Velegzhaninov
In the present work, we investigated the dark and photoinduced cytotoxic activity of the new chlorophyll-a derivatives which contain the substituents of oligoethylene glycol on the periphery of their macrocycles. These compounds were tested using human cell lines to estimate their potential as photosensitizers for photodynamic therapy of cancer. It was shown that all the tested compounds have expressed photoinduced cytotoxic activity in vitro. Detailed study of the biological activity of one of the most perspective compound in this series-pyropheophorbide-a 17-diethylene glycol ester (Compound 21) was performed...
January 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28067486/photocrosslinkable-polymer-dots-with-stable-sensitizer-loading-and-amplified-singlet-oxygen-generation-for-photodynamic-therapy
#19
Ying Tang, Haobin Chen, Kaiwen Chang, Zhihe Liu, Yu Wang, Songnan Qu, Hong Xu, Changfeng Wu
Photodynamic therapy (PDT) is a promising treatment modality for clinical cancer therapy. However, the therapeutic effect of PDT is strongly dependent on the property of photosensitizer. Here, we developed photocrosslinkable semiconductor polymer dots doped with photosensitizer Chlorin e6 (Ce6) to construct a nanoparticle platform for photodynamic therapy. Photo-reactive oxetane groups were attached to the side chains of the semiconductor polymer. After photocrosslinking reaction, the Ce6-doped Pdots formed an interpenetrated structure to prevent Ce6 leaching out from the Pdot matrix...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28067380/a-single-light-triggered-and-dual-imaging-guided-multifunctional-platform-for-combined-photothermal-and-photodynamic-therapy-based-on-td-controlled-and-icg-loaded-cus-msio2
#20
Qing You, Qi Sun, Jinping Wang, Xiaoxiao Tan, Xiaojuan Pang, Li Liu, Meng Yu, Fengping Tan, Nan Li
Near-infrared (NIR)-responsive drug delivery systems have received enormous attention because of their good biocompatibility and high biological penetration. In this work, we report a novel 1-tetradecanol (TD)-controlled and indocyanine green (ICG)-loaded CuS@mSiO2 phototherapy nanoplatform (CuS@mSiO2-TD/ICG). The CuS@mSiO2 nanoparticles prepared by a facile one-pot approach can serve as drug-delivery vehicles to transport the NIR absorbing phototherapeutic agent (ICG) within the mesoporous cavities. Meanwhile a phase-change molecule (PCM), TD, is introduced as a thermosensitive gatekeeper to avoid the premature release of loaded ICG...
January 9, 2017: Nanoscale
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