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Photodynamic therapy cancer

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https://www.readbyqxmd.com/read/27911871/inhibition-of-cancer-antioxidant-defense-by-natural-compounds
#1
Alicja Sznarkowska, Anna Kostecka, Katarzyna Meller, Krzysztof Piotr Bielawski
All classic, non-surgical anticancer approaches like chemotherapy, radiotherapy or photodynamic therapy kill cancer cells by inducing severe oxidative stress. Even tough chemo- and radiotherapy are still a gold standard in cancer treatment, the identification of non-toxic compounds that enhance their selectivity, would allow for lowering their doses, reduce side effects and risk of second cancers. Many natural products have the ability to sensitize cancer cells to oxidative stress induced by chemo- and radiotherapy by limiting antioxidant capacity of cancer cells...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27911279/microrna-101-inhibits-proliferation-migration-and-invasion-of-human-glioblastoma-by-targeting-sox9
#2
Nan Liu, Lei Zhang, Zhen Wang, Yingduan Cheng, Pengxing Zhang, Xin Wang, Weihong Wen, Hongwei Yang, Hui Liu, Weilin Jin, Yongsheng Zhang, Yanyang Tu
Glioblastoma multiforme (GBM) is the most common primary malignant tumors originating in the brain parenchyma. At present, GBM patients have a poor prognosis despite the continuous progress in therapeutic technologies including surgery, radiotherapy, photodynamic therapy, and chemotherapy. Recent studies revealed that miR-101 was remarkably down-regulated in kinds of human cancers and was associated with aggressive tumor cell proliferation and stem cell self-renewal. Data also showed that miR-101 was down-regulated in primary glioma samples and cell lines, but the underlying molecular mechanism of the deregulation of miR-101 in glioma remained largely unknown...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27910740/oral-squamous-cell-carcinoma-current-treatment-strategies-and-nanotechnology-based-approaches-for-prevention-and-therapy
#3
Sankalp A Gharat, Munira Momin, Chintan Bhavsar
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer; it involves damage to oral epithelial cells due to accumulation of multiple genetic mutations in the cells. OSCC remains major cause of morbidity and mortality in patients with head and neck cancers. Tobacco, smoking, alcohol consumption alone or with chewing tobacco, and betel quid are potential carcinogens contributing to the high occurrence of OSCC. Current treatment modalities for OSCC like chemoradiotherapy, surgery, EGFR inhibitors and COX-2 inhibitors, and photodynamic therapy have led to the major problems related to non-specific cell death...
2016: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/27904858/interventional-therapy-of-esophageal-cancer
#4
REVIEW
Aiwu Mao
Esophageal cancer (EC) is the fourth leading cause of cancer death in China. Despite a lot of advances in diagnosis and therapy, the survival rate of patients with EC is low. There is urgent need for a variety of methods and techniques to improve the survival time and alleviate the lesions of EC. Nowadays, alternative and less invasive approaches to the treatment of ECs are being identified. Here, we review several main interventional methods at different stages of EC, including endoscopic resection, stent placement, arterial infusion, photodynamic therapy, and radiofrequency ablation...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27903969/targeting-tissue-factor-as-a-novel-therapeutic-oncotarget-for-eradication-of-cancer-stem-cells-isolated-from-tumor-cell-lines-tumor-xenografts-and-patients-of-breast-lung-and-ovarian-cancer
#5
Zhiwei Hu, Jie Xu, Jijun Cheng, Elizabeth McMichael, Lianbo Yu, William E Carson Iii
Targeting cancer stem cell (CSC) represents a promising therapeutic approach as it can potentially fight cancer at its root. The challenge is to identify a surface therapeutic oncotarget on CSC. Tissue factor (TF) is known as a common yet specific surface target for cancer cells and tumor neovasculature in several solid cancers. However, it is unknown if TF is expressed by CSCs. Here we demonstrate that TF is constitutively expressed on CD133 positive (CD133+) or CD24-CD44+ CSCs isolated from human cancer cell lines, tumor xenografts from mice and breast tumor tissues from patients...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27903435/lack-of-effect-of-selected-sunscreens-applied-on-ex-vivo-human-skin-for-5-methyl-aminolevulinic-acid-penetration-and-protoporphyrin-ix-photoactivation
#6
Hanan Osman-Ponchet, Karine Sevin, Alexandre Gaborit, Magali Kouidhi, Johanna Hanaizi, Pierre Comby, Bernard Ruty, Guy Bouvier
BACKGROUND: Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers. Methyl-aminolevulinate (MAL) is metabolized to protoporphyrin IX (PpIX) which accumulates in the skin lesion and which generates a painful photochemical toxic reaction upon red light exposure. PDT using daylight (DL) exposure is now used to reduce pain and subjects are advised to protect the areas with sunscreen. This work investigated the effect of sunscreen on MAL penetration and PpIX photoactivation in ex vivo human skin...
November 26, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27896346/visible-light-driven-mesoporous-ag-embedded-zno-nanocomposites-reactive-oxygen-species-enhanced-photocatalysis-bacterial-inhibition-and-photodynamic-therapy
#7
Jagriti Gupta, Jeotikanta Mohapatra, D Bahadur
We present here the multitasking capabilities of Ag-embedded ZnO nanocomposites (Ag-ZnO NCs), which include the photocatalytic degradation of organic dyes, bacterial inhibition, and cancer therapeutics. Ag-embedded ZnO nanocomposites (Ag-ZnO NCs) of mesoporous spherical morphology (size ∼ 150 ± 50 nm) are successfully synthesized by a facile and single step soft-chemical approach. To understand the effect of Ag loading on multitasking properties, Ag-ZnO NCs are synthesized with different wt% of Ag. It was found that Ag5-ZnO NCs (5 wt% of Ag) showed excellent solar light-induced photocatalytic degradation properties against both cationic as well as anionic dyes...
November 29, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27896250/clinical-efficacy-of-photodynamic-therapy
#8
Ye-Kyu Park, Choong-Hak Park
OBJECTIVE: The management of cervical intraepithelial neoplasia (CIN) and early invasive cancer of the uterine cervix is very difficult to approach, especially in case of young woman who wants to preserve her fertility. Conization of the cervix may have various kinds of disadvantage. The objective of this clinical retrospective study is to investigate the therapeutic effects and clinical efficacy of photodynamic therapy (PDT) including combined chemo-photodynamic therapy in patients with pre-malignant CIN and malignant invasive cervical cancer...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27892657/effective-delivery-of-porphyrazine-photosensitizers-to-cancer-cells-by-polymer-brush-nanocontainers
#9
Natalia Y Shilyagina, Nina N Peskova, Svetlana A Lermontova, Anna A Brilkina, Vladimir A Vodeneev, Alexander V Yakimasky, Larisa G Klapshina, Irina V Balalaeva
Efficient drug delivery can be assigned to tasks that attract the most acute attention of researchers in the field of anticancer drug design. We have reported the first case of using amphiphilic polymer brushes as nanocontainers for photosensitizer delivery to cancer cells. Regular graft-copolymers of hydrophobic polyimides with hydrophilic polymethacrylic acid side chains were loaded with photosensitive dye tetra(4-fluorophenyl)tetracyanoporphyrazine (Pz) providing a sufficiently stable homogeneous fraction of fluorescent Pz-loaded nanoparticles with a size of 100-150 nm...
November 28, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27890732/programmed-near-infrared-light-responsive-drug-delivery-system-for-combined-magnetic-tumor-targeting-magnetic-resonance-imaging-and-chemo-phototherapy
#10
Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Yongwei Hao, Yongchao Wang, Hongling Zhang, Lin Hou, Zhenzhong Zhang
: In this study, an intelligent drug delivery system was developed by capping doxorubicin (DOX)-loaded hollow mesoporous CuS nanoparticles (HMCuS NPs) with superparamagnetic iron oxide nanoparticles (IONPs). Under near infrared (NIR) light irradiation, the versatile HMCuS NPs could exploit the merits of both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Herein, the multifunctional IONPs as gatekeeper with the enhanced capping efficiency were supposed to realize "zero premature release" and minimize the adverse side effects during the drug delivery in vivo...
November 24, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27890002/photosensitizers-for-photodynamic-therapy-photochemistry-in-the-service-of-oncology
#11
Carsten Lange, Patrick J Bednarski
The combined use of a photosensitizing agent, light and dioxygen for the treatment of diseases has become known as photodynamic therapy (PDT) and was first discovered more than one hundred years ago. Over the years, PDT has proven its potential for the treatment of malignant and non-malignant lesions in addition to classical cancer therapy in numerous clinical studies, but application as a routine method is still limited. In this review, the development of modern PDT since the beginning of the twentieth century is briefly portrayed...
November 24, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27889618/cell-death-mechanistic-study-of-photodynamic-therapy-against-breast-cancer-cells-utilizing-liposomal-delivery-of-5-10-15-20-tetrakis-benzo-b-thiophene-porphyrin
#12
Geewoo Nam, Sabarinathan Rangasamy, Hee Ju, Annie Agnes Suganya Samson, Joon Myong Song
5,10,15,20-Tetrakis(benzo[b]thiophene) porphyrin (BTP) is a newly synthesized hydrophobic photosensitizer with fluorescence quantum yield in toluene: ΦF=0.062. Previously, its limitations in solubility had hindered scientific experimentation regarding its photodynamic effects on cancer cells. By utilizing various compositions of liposomes in order to alter the solubility of BTP, the photocytotoxicity, reactive oxygen species generation, and subcellular localization of the liposomal BTP were identified in this work...
November 12, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27884704/enhanced-aggressiveness-of-bystander-cells-in-an-anti-tumor-photodynamic-therapy-model-role-of-nitric-oxide-produced-by-targeted-cells
#13
Jerzy Bazak, Jonathan M Fahey, Katarzyna Wawak, Witold Korytowski, Albert W Girotti
The bystander effects of anti-cancer ionizing radiation have been widely studied, but far less is known about such effects in the case of non-ionizing photodynamic therapy (PDT). In the present study, we tested the hypothesis that photodynamically-stressed prostate cancer PC3 cells can elicit nitric oxide (NO)-mediated pro-growth/migration responses in non-stressed bystander cells. A novel approach was used whereby both cell populations existed on a culture dish, but made no physical contact with one other...
November 22, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27879628/carbon-based-materials-for-photo-triggered-theranostic-applications
#14
REVIEW
Karunya Albert, Hsin-Yun Hsu
Carbon-based nanomaterials serve as a type of smart material for photo-triggered disease theranostics. The inherent physicochemical properties of these nanomaterials facilitate their use for less invasive treatments. This review summarizes the properties and applications of materials including fullerene, nanotubes, nanohorns, nanodots and nanographenes for photodynamic nanomedicine in cancer and antimicrobial therapies. Carbon nanomaterials themselves do not usually act as photodynamic therapy (PDT) agents owing to the high hydrophobicity, however, when the surface is passivated or functionalized, these materials become great vehicles for PDT...
November 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27877247/beyond-the-barriers-of-light-penetration-strategies-perspectives-and-possibilities-for-photodynamic-therapy
#15
REVIEW
Srivalleesha Mallidi, Sriram Anbil, Anne-Laure Bulin, Girgis Obaid, Megumi Ichikawa, Tayyaba Hasan
Photodynamic therapy (PDT) is a photochemistry based treatment modality that involves the generation of cytotoxic species through the interactions of a photosensitizer molecule with light irradiation of an appropriate wavelength. PDT is an approved therapeutic modality for several cancers globally and in several cases has proved to be effective where traditional treatments have failed. The key parameters that determine PDT efficacy are 1. the photosensitizer (nature of the molecules, selectivity, and macroscopic and microscopic localization etc...
2016: Theranostics
https://www.readbyqxmd.com/read/27877240/ros-responsive-mitochondria-targeting-blended-nanoparticles-chemo-and-photodynamic-synergistic-therapy-for-lung-cancer-with-on-demand-drug-release-upon-irradiation-with-a-single-light-source
#16
Caixia Yue, Yuming Yang, Chunlei Zhang, Gabriel Alfranca, Shangli Cheng, Lijun Ma, Yanlei Liu, Xiao Zhi, Jian Ni, Weihua Jiang, Jie Song, Jesús M de la Fuente, Daxiang Cui
Mitochondria in cancer cells maintain a more negative membrane potential than normal cells. Mitochondria are the primary source of cellular reactive oxygen species (ROS), which are necessary for photodynamic therapy. Thus, the strategy of targeting mitochondria can maximize the photodynamic therapeutic efficiency for cancer. Here we report, for the first time, synthesis of a new mitochondria-targeting drug delivery system, ZnPc/CPT-TPPNPs. To synthesize this novel compound, polyethylene glycol was functionalized with thioketal linker-modified camptothecin (TL-CPT) and triphenylphosphonium to form the block copolymer, TL-CPT-PEG1K-TPP...
2016: Theranostics
https://www.readbyqxmd.com/read/27877235/x-ray-induced-photodynamic-therapy-a-combination-of-radiotherapy-and-photodynamic-therapy
#17
Geoffrey D Wang, Ha T Nguyen, Hongmin Chen, Phillip B Cox, Lianchun Wang, Koichi Nagata, Zhonglin Hao, Andrew Wang, Zibo Li, Jin Xie
Conventional photodynamic therapy (PDT)'s clinical application is limited by depth of penetration by light. To address the issue, we have recently developed X-ray induced photodynamic therapy (X-PDT) which utilizes X-ray as an energy source to activate a PDT process. In addition to breaking the shallow tissue penetration dogma, our studies found more efficient tumor cell killing with X-PDT than with radiotherapy (RT) alone. The mechanisms behind the cytotoxicity, however, have not been elucidated. In the present study, we investigate the mechanisms of action of X-PDT on cancer cells...
2016: Theranostics
https://www.readbyqxmd.com/read/27876448/magnetic-nanoparticles-for-precision-oncology-theranostic-magnetic-iron-oxide-nanoparticles-for-image-guided-and-targeted-cancer-therapy
#18
Lei Zhu, Zhiyang Zhou, Hui Mao, Lily Yang
Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal- or photodynamic response...
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27875977/theranostics-based-on-iron-oxide-and-gold-nanoparticles-for-imaging-guided-photothermal-and-photodynamic-therapy-of-cancer
#19
S Rajkumar, M Prabaharan
With the progress of nanotechnology, the treatment of cancer by photothermal therapy (PTT) and photodynamic therapy (PDT) using theranostic nanomaterials based on iron oxide (Fe3O4) and gold (Au) nanoparticles (NPs) has received much attention in recent years. The Fe3O4 NPs have been used as imaging-guided PTT of cancer due to their high relaxivity, excellent contrast enhancement, and less toxicity. The Au NPs have been widely employed as a contrast agent for CT imaging of different biological systems due to their enhanced X-ray attenuation property...
November 22, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27874144/a-novel-photosensitizer-an-l-glutamide-lipid-conjugate-with-improved-properties-for-photodynamic-therapy
#20
Erica Nathan, K Vijayashree, A Harikrishna, Makoto Takafuji, Hirokuni Jintoku, Hirotaka Ihara, N M Rao
Photosensitizers (PS) are used in photodynamic therapy to treat several cancers. The efficacy of photodynamic therapy (PDT) could be further improved by overcoming aggregation-dependent quenching of PS and by improving the biodistribution of the PS. In this work we attempted to overcome these issues by conjugating a PS with a lipid molecule and tested the liposomes prepared with this PS conjugated lipid for PDT. A novel lipid-porphyrin conjugate (1 : 1) was synthesized by attaching a PS, 5-(4-methoxycarbonylphenyl)-10,15,20-triphenyl-(21)H,(23)H-porphine, to the head group of a glutamide lipid...
November 30, 2016: Photochemical & Photobiological Sciences
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