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Vascular calcifications

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https://www.readbyqxmd.com/read/29689558/fibulin-3-attenuates-phosphate-induced-vascular-smooth-muscle-cell-calcification-by-inhibition-of-oxidative-stress
#1
Trang T D Luong, Nadeshda Schelski, Beate Boehme, Manousos Makridakis, Antonia Vlahou, Florian Lang, Burkert Pieske, Ioana Alesutan, Jakob Voelkl
BACKGROUND/AIMS: Fibulin-3, an extracellular matrix glycoprotein, inhibits vascular oxidative stress and remodeling in hypertension. Oxidative stress is prevalent in chronic kidney disease (CKD) patients and is an important mediator of osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells (VSMCs) during hyperphosphatemia. Therefore, the present study explored the effects of Fibulin-3 on phosphate-induced vascular calcification. METHODS: Experiments were performed in primary human aortic smooth muscle cells (HAoSMCs) treated with control or with phosphate without or with additional treatment with recombinant human Fibulin-3 protein or with hydrogen peroxide as an exogenous source of oxidative stress...
April 18, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689070/fti-277-inhibits-smooth-muscle-cell-calcification-by-up-regulating-pi3k-akt-signaling-and-inhibiting-apoptosis
#2
Arvind Ponnusamy, Smeeta Sinha, Gareth D Hyde, Samantha J Borland, Rebecca F Taylor, Emma Pond, Heather J Eyre, Colette A Inkson, Andrew Gilmore, Nick Ashton, Philip A Kalra, Ann E Canfield
BACKGROUND: Vascular calcification is associated with increased cardiovascular morbidity and mortality in patients with atherosclerosis, diabetes and chronic kidney disease. However, no viable treatments for this condition have been identified. This study aimed to determine whether farnesyl transferase inhibitors (FTIs) can reduce vascular calcification and the mechanism by which this reduction occurs. RESULTS: We demonstrate that FTI-277 significantly inhibits phosphate-induced mineral deposition by vascular smooth muscle cells (VSMC) in vitro, prevents VSMC osteogenic differentiation, and increases mRNA expression of matrix Gla protein (MGP), an inhibitor of mineralization...
2018: PloS One
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#3
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29678621/activation-of-the-non-canonical-nf-%C3%AE%C2%BAb-p52-pathway-in-vascular-endothelial-cells-by-rankl-elicits-pro-calcific-signalling-in-co-cultured-smooth-muscle-cells
#4
Emma Harper, Keith D Rochfort, Hannah Forde, Colin Davenport, Diarmuid Smith, Philip M Cummins
BACKGROUND: The intimal endothelium is known to condition the underlying medial smooth muscle cell (SMC) layer of the vessel wall, and is highly responsive to receptor-activator of nuclear factor-κB ligand (RANKL) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL), pro-calcific and anti-calcific agents, respectively. In this paper, we tested the hypothesis that RANKL-induced activation of endothelial NF-κB signalling is essential for pro-calcific activation of the underlying SMCs...
April 17, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29677036/coupled-opg-fc-on-decellularized-aortic-valves-by-edc-nhs-attenuates-rat-mscs-calcification-in-vitro
#5
Qiao Zhang, Si Chen, Jiawei Shi, Fei Li, Xucong Shi, Xingjian Hu, Cheng Deng, Feng Shi, Guichun Han, Nianguo Dong
Valve calcification commonly damages natural human heart valves and tissue-engineered heart valves (TEHVs), and no ideal intervention is available in clinical practice. It is increasingly considered that osteoprotegerin (OPG) inhibits vascular calcification. We aimed to explore whether free OPG-Fc fusion protein or coupled OPG-Fc on decellularized aortic valves attenuates calcification. Calcification of rat bone marrow-derived mesenchymal stromal cells (MSCs) was induced by osteogenic differentiation media, and the effects of free OPG-Fc or OPG-Fc coupled on the decellularized porcine aortic heart valve leaflet scaffolds by coupling agents 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) on calcification were observed...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29672176/prevalence-and-risk-factors-for-vascular-calcification-in-chinese-patients-receiving-dialysis-baseline-results-from-a-prospective-cohort-study
#6
Zhi-Hong Liu, Xue-Qing Yu, Jun-Wei Yang, Ai-Li Jiang, Bi-Cheng Liu, Chang-Ying Xing, Ji-Zhuang Lou, Mei Wang, Hong Cheng, Jun Liu, Jun-Zhou Fu, Ai-Hua Zhang, Miao Zhang, Qiao-Ling Zhou, Chen Yu, Rong Wang, Li Wang, Yu-Qing Chen, Tian-Jun Guan, Ai Peng, Chen Nan, Chuan-Ming Hao, Xu-Yang Cheng
OBJECTIVE: With limited data available on calcification prevalence in chronic kidney disease (CKD) patients on dialysis, the China Dialysis Calcification Study (CDCS) determined the prevalence of vascular/valvular calcification (VC) and association of risk factors in Chinese patients with prevalent hemodialysis (HD) or peritoneal dialysis (PD). METHODS: CKD patients undergoing HD/PD for ≥6 months were enrolled. Prevalence data for calcification and medical history were documented at baseline...
April 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29671909/should-phosphate-management-be-limited-to-the-kdigo-kdoqi-guidelines
#7
Sangeet Dhillon-Jhattu, Stuart M Sprague
Hyperphosphatemia is a common complication of CKD. Prior to development of overt hyperphosphatemia, there are several adaptive mechanisms that occur to maintain normal phosphorus equilibrium in patients with CKD. These include an early and progressive rise in fibroblast growth factor 23 (FGF 23), followed by an increase in parathyroid hormone (PTH) with a decrease in 1,25-dihydroxyvitamin D (1,25 Vit D). Over the last 20 years, a large number of studies have shown that hyperphosphatemia is a strong predictor of adverse clinical outcomes including increased incidence of vascular calcification, cardiovascular disease, and all-cause mortality in both individuals with CKD as well as those with normal kidney function...
April 19, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29665789/idiopathic-basal-ganglia-calcification-associated-with-cerebral-micro-infarcts-a-case-report
#8
Takuma Nishimoto, Fumiaki Oka, Hideyuki Ishihara, Mizuya Shinoyama, Michiyasu Suzuki
BACKGROUND: Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide challenge. CASE PRESENTATION: A 66-year-old male presented with right conjugate deviation, right hemiparesis and total aphasia due to a convulsive seizure...
April 17, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29664315/potential-correlation-between-circulating-fetuin-a-and-pentraxin-3-with-biochemical-parameters-of-calcification-in-hemodialysis-patients
#9
Javad Hashemi, Hamid-Reza Joshaghani, Arash Akaberi, Zahra Hesari, Reza Ghanbari, Mohsen Mohammadzadeh, Ali-Reza Golshan
BACKGROUND: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29662315/pitfalls-in-the-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity
#10
Dai Ato
Background: The ankle-brachial index (ABI) and pulse wave velocity (PWV) are indices of atherosclerosis and arterial stiffness. The Japan-made measuring devices of those indices have spread widely because of their convenience and the significance of the parameters. However, studies that comprehensively discuss the various pitfalls in using these indices are not available. Methods: This study presents several representative pitfalls in using the ABI and brachial-ankle PWV (baPWV) by showing the result sheets of the device, "the Vascular Profiler"...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29661746/effects-of-oral-vitamin-d-3-supplementation-in-stage-3-chronic-kidney-disease-subjects-insulin-resistance-syndrome-and-hormonal-disturb-interactions
#11
Amina Tahar, Faiza Zerdoumi, Messaoud Saidani, Lakhdar Griene, Elhadj-Ahmed Koceir
The 1-25-hydroxyvitamine D (1-25OHD) or calcitriol deficiency in chronic kidney disease (CKD) patients was associated with increases vascular calcification risk, nephrons reduction, bone deficit and cardiovascular mortality by atherosclerosis. The objective of this study was to investigate the pleiotropic effects of 200.000 IU (D200 group) every 3 months versus 30.000 IU (D30 group) every month dose vitamin D supplementation in stage 3 CKD patients. A cohort of 132 adult subjects was randomized into 2 groups according to dose vitamin D supplementation in deficient subjects (25OHD <50 nmol/L or <20 ng/mL)...
April 16, 2018: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29661648/one-year-rat-study-of-ibta-induced-microbiotube-microvascular-grafts-with-an-ultra-small-diameter-of-0-6-mm
#12
Daizo Ishii, Jun-Ichiro Enmi, Ryosuke Iwai, Kaoru Kurisu, Eisuke Tatsumi, Yasuhide Nakayama
OBJECTIVE: The world's smallest calibre "microbiotube" vascular graft was recently developed, with an inner diameter of 0.6 mm. It was formed using in-body tissue architecture (iBTA) and has a high degree of patency and capacity for regeneration in the acute phase, 1 month after implantation. This consecutive study investigated the compatibility and stability of microbiotubes in the chronic phase of implantation for 12 months for potential application in microsurgery. METHODS: This was an in vivo experimental study...
April 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29658328/effects-of-enoxaparin-on-intravascular-sclerostin-release-in-healthy-men
#13
Jacek Borawski, Justyna Zoltko, Barbara Labij-Reduta, Ewa Koc-Zorawska, Beata Naumnik
Sclerostin (Scl) is implicated in vascular calcification and angiogenesis and localizes within vasculature. Its molecule incorporates a heparin-binding site that implies also binding to endothelial glycocalyx. We preliminary tested whether intravenous (IV) low-molecular-weight heparin enoxaparin can stimulate intravascular release of this calcification inhibitor in humans. Sixteen male volunteers were injected with a bolus of 1 mg/kg body weight of enoxaparin. After 10 minutes, plasma immunoreactive Scl levels increased uniformly by a mean of 184% versus baseline level of 0...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#14
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29643466/etidronate-prevents-dystrophic-cardiac-calcification-by-inhibiting-macrophage-aggregation
#15
Carolin Bauer, Olivier le Saux, Viola Pomozi, Redouane Aherrahrou, Rene Kriesen, Stephanie Stölting, Annett Liebers, Thorsten Kessler, Heribert Schunkert, Jeanette Erdmann, Zouhair Aherrahrou
Cardiovascular calcification is associated with high risk of vascular disease. This involves macrophage infiltration of injured vascular tissue and osteoclast-related processes. Splenic monocytes from mice, that are predisposed (C3H) or resistant (B6) to calcification, were isolated and differentiated in vitro with M-CSF to generate macrophages, which aggregate to form multinucleated (MN) cells in the presence of RANKL. MN cell formation was significantly decreased in monocytes from resistant compared with calcifying mice...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29629538/changes-in-the-common-carotid-artery-after-radiotherapy-wall-thickness-calcification-and-atherosclerosis
#16
Bum Joon Kim, Hyun Goo Kang, Sang Wook Lee, Jinhong Jung, Min Hwan Lee, Dong Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND AND PURPOSE: Since the long-term survival rate has improved in laryngeal cancer patients who receive radiotherapy, concerns about postradiation complications (including carotid atherosclerosis) have increased. We followed changes in the common carotid artery (CCA) after radiotherapy and identified the underlying risk factors. METHODS: Consecutive patients with laryngeal cancer who underwent radiotherapy between January 1999 and December 2009 and who had received computed tomography (CT) both pre- and postradiotherapy were enrolled...
January 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29626090/a-gtpase-activating-protein-binding-protein-g3bp1-antiviral-protein-relay-conveys-arteriosclerotic-wnt-signals-in-aortic-smooth-muscle-cells
#17
Bindu Ramachandran, John N Stabley, Su-Li Cheng, Abraham S Behrmann, Austin Gay, Li Li, Megan Mead, Julia Kozlitina, Andrew Lemoff, Hamid Mirzaei, Zhijian Chen, Dwight A Towler
In aortic vascular smooth muscle (VSM), the canonical Wnt receptor LRP6 inhibits protein arginine (Arg) methylation, a new component of noncanonical Wnt signaling that stimulates nuclear factor of activated T cells (viz., NFATc4). To better understand how methylation mediates these actions, mass spectrometry was performed on VSM cell extracts from control and LRP6-deficient mice. LRP6-dependent Arg methylation was regulated on > 500 proteins; only 21 exhibited increased monomethylation (MMA) with concomitant reductions in dimethylation...
April 6, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29622969/relationship-between-serum-osteoprotegerin-and-vascular-calcifications-in-hemodialysis-patients
#18
Tarek Z El Baz, Osama A Khamis, Amal El-Shehaby, Hussein Chahine, Ahmad Alaa Al-Din Ahmed, Mostafa A Alsawasany
Background: Uremia is a vasculopathic process, and both cardiac calcification and vascular calcification seen from the early stages of chronic kidney disease. Osteoprotegerin could play a crucial role in atherosclerotic plaque formation, maturation and calcification. The goal of this study was to determine the relationship of serum osteoprotegerin with vascular calcification in patients with end stage kidney disease who were maintained on regular hemodialysis. Methods: Sixty clinically stable chronic renal failure patients undergoing regular hemodialysis were enrolled in this cross sectional study...
June 2017: Egypt Heart J
https://www.readbyqxmd.com/read/29621750/enhanced-vascular-biocompatibility-and-remodeling-of-decellularized-and-secured-xenogeneic-allogeneic-matrices-in-a-porcine-model
#19
Mathieu van Steenberghe, Thomas Schubert, Caroline Bouzin, Carlo Caravaggio, Yves Guiot, Daela Xhema, Pierre Gianello
BACKGROUND/PURPOSE: Calcifications and absence of growth potential are the major drawbacks of glutaraldehyde-treated prosthesis. Decellularized and secured xeno-/allogeneic matrices were assessed in a preclinical porcine model for biocompatibility and vascular remodeling in comparison to glutaraldehyde-fixed bovine pericardium (GBP; control). METHODS: Native human (fascia lata, pericardium) and porcine tissues (peritoneum) were used and treated. In vitro, biopsies were performed before and after treatment to assess decellularization (hematoxylin and eosin/DAPI)...
April 5, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/29619907/severe-atherosclerosis-in-donor-liver-vasculature-an-illustrative-case-report-and-review-of-the-literatur
#20
Ayokunle S Olowofela, Oscar K Serrano, Raja Kandaswamy
As the scarcity of transplantable organs continues to increase, juxtaposed with an aging donor population, transplant surgeons are increasingly confronted with marginal organ offers. The presence of atherosclerosis in the donor allograft has been shown to compromise the vascular integrity and predispose to vascular complications in the transplanted liver. Here, we present a case of 54-year-old brain-dead donor who was discovered to have a severely diseased aorta during organ recovery. Pathologic evaluation revealed severe atherosclerosis with calcifications...
April 4, 2018: Experimental and Clinical Transplantation
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