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Vascular calcifications

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https://www.readbyqxmd.com/read/29223135/simultaneous-anti-diabetic-and-anti-vascular-calcification-activity-of-nocardia-sp-utmc-751
#1
Fatemeh Salimi, Saeedeh Jafari-Nodooshan, Nazanin Zohourian, Sedighe Kolivand, Javad Hamedi
Alpha-amylase can act as a significant player in causing hyperglycemia, leading to protein glycation, which is the main complication in this condition, besides causing vascular calcification (VC), an important vascular failure caused due to thisIn order to find a natural source of the biocompounds with inhibitory effects on alpha-amylase,, fifteen fermentation broth extracts of actinobacteria (FBEA) (200 μg mL-1 ) have been screened. Finally, the effects of the most efficient FBE have been investigated on osteopontin (OPN, a VC marker) mRNA level in the vascular smooth muscle cells under the calcification conditions, and the chemical constituents of the most efficient FBE were analyzed using GC-MS analysis...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29218425/ionized-and-total-serum-magnesium-in-hemodialysis-predictors-and-variability-a-longitudinal-cross-sectional-study
#2
Rosaria Del Giorno, Hilary Riva, Gaetano Donato, Luca Gabutti
BACKGROUND: Ionized Magnesium (ion-Mg) represents the active biological fraction of the serum magnesium content. The assessment of total serum Mg (tot-Mg) might not accurately identify patients with hypo-or hyper-magnesaemie. In hemodialysis, serum tot-Mg levels in the upper part of the distribution, have been associated with reduced mortality and fewer vascular calcifications; thus, resulting in the tendency to increase the Mg concentration in the dialysate, traditionally set at 0.5 mmol/L...
December 7, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29217507/multidisciplinary-approach-to-understand-medial-arterial-calcification
#3
Ophélie Gourgas, Juliana Marulanda, Peng Zhang, Monzur Murshed, Marta Cerruti
OBJECTIVE: Vascular calcification significantly increases morbidity in life-threatening diseases, and no treatments are available because of lack of understanding of the underlying molecular mechanism. Here, we study the physicochemical details of mineral nucleation and growth in an animal model that faithfully recapitulates medial arterial calcification in humans, to understand how pathological calcification is initiated on the vascular extracellular matrix. APPROACH AND RESULTS: MGP (matrix Gla protein) is a potent mineralization inhibitor...
December 7, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29215755/apelin-apj-system-a-critical-regulator-of-vascular-smooth-muscle-cell
#4
REVIEW
Xuling Luo, Jiaqi Liu, Hong Zhou, Linxi Chen
APJ, an orphan G protein-coupled receptor, is first identified through homology cloning in 1993. Apelin is endogenous ligand of APJ extracted from bovine stomach tissue in 1998. Apelin/APJ system is widely expressed in many kinds of cells such as endothelial cells, cardiomyocytes, especially vascular smooth muscle cell. Vascular smooth muscle cell, an integral part of the vascular wall, takes part in many normal physiological processes. Our experiment firstly finds that apelin/APJ system enhances VSMC proliferation by ERK1/2-cyclin D1 signal pathway...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29211369/-rare-vascular-diseases-building-dedicated-multidisciplinary-specialized-center
#5
Caroline Krieger, David Baud, Judith Bouchardy, Stephanie Christen-Zaech, Anthony De Buys, Sebastien Deglise, Oumama El Ezzi, Marco Fresa, Michael Hofer, Daniel Hohl, Matthias Kirsch, Romain Lazor, Patrick Michel, Pierre Monney, Francis Munier, Salah Dine Qanadli, Wassim Raffoul, Berangere Aubry Rozier, François Saucy, Alain Schoepfer, Guillaume Saliou, Nicole Sekarski, Andrea Superti-Furga, Gregoire Wuerzner, Jean-Blaise Wasserfallen, Lucia Mazzolai
Rare Vascular Diseases (RVD) encompass different types of vessel involvement. Some cause a dilation, others a weakening or tortuosity of the arterial wall, others an obstruction or excessive calcification of arterial walls. Clinical pathway of patients with RVD to diagnosis is often long and complex. Thus, in order to allow early diagnosis and coordinated multidisciplinary management and follow-up, a specialized RVD centre has been set-up at the CHUV, following the framework of the national concept of rare diseases...
December 6, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29210840/conoscere-e-curare-il-cuore-1986-2016-how-the-heart-has-changed
#6
Alessandro Boccanelli
: The demographic transition, with longer life expectancy, is mainly due to prevention and care of atherosclerotic vascular and heart disease. The cardiovascular patient is now much older and often presents with coexisting geriatric syndromes that affect healthcare goals, outcomes, and the process of care. Numerous mechanisms at cellular level are responsible for cardiovascular aging such as replicative senescence, apoptosis, proteins misfolding, and inflammation. Aging-related modifications are increase in left-ventricular mass, increased left atrial size, myocardial collagen deposition, and calcium deposition in valvular structures and the coronary arteries...
November 27, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29208463/stellate-ganglion-block-ameliorates-vascular-calcification-by-inhibiting-endoplasmic-reticulum-stress
#7
Wei Hao, Rui Yang, Yang Yang, Sheng Jin, Yanqing Li, Fang Yuan, Qi Guo, Lin Xiao, Xin Wang, Fuwei Wang, Yuming Wu, Xu Teng
AIMS: Vascular calcification (VC) underlies substantial cardiovascular morbidity and mortality. No clinically therapies have emerged presently. Stellate ganglion block (SGB) is one of the most often used sympathetic blockade procedure, and regulates vascular dilation. However, the effect of SGB on VC is still unknown. Therefore, we aimed to identify the ameliorative effect of SGB on VC. KEY FINDING: In vivo VC was induced in rats by administering vitamin D3 plus nicotine (VDN), and in vitro calcification of rat aortic vascular smooth muscle cells (VSMC) was induced by β-glycerophosphate...
December 2, 2017: Life Sciences
https://www.readbyqxmd.com/read/29207805/benign-lesions-on-screening-mammography-increasing-diagnostic-confidence-in-a-hitherto-unscreened-population
#8
Piyush Joshi, Rohit Sharma
Introduction: Screening mammography is used for detection of breast cancer and is interpreted using the Breast Image Reporting and Data System (BIRADS) convention. It is not routinely offered to women in countries which do not have a national screening programme resulting in a challenge for the radiologist who has to interpret these in the absence of previous mammograms. Aim: To analyse benign and probably benign lesions in screening mammograms in a hitherto unscreened population and suggest protocols to increase diagnostic confidence...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207225/-association-between-vertebral-fractures-and-vascular-calcifications
#9
REVIEW
Giovanni Piscopo, Luigi Morrone
Several cross-sectional and prospective studies highlight the existence of an association between bone fractures and abdominal aortic calcifications, especially if particularly severe and independent from confounders such as aging, smoking habits and diabetes. This phenomenon affects not only the general population but also patients with chronic kidney disease in which cortical bone lesions are prevalent. Moreover, bone fractures and aortic calcifications have been proved to be linked to increased cardiovascular morbidity and mortality, both in the general populations and in patients with chronic kidney disease, who notoriously show elevated cardiovascular risks...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/29207136/exploiting-novel-valve-interstitial-cell-lines-to-study-calcific-aortic-valve-disease
#10
Hiu-Gwen Tsang, Lin Cui, Colin Farquharson, Brendan M Corcoran, Kim M Summers, Vicky E Macrae
Calcific aortic valve disease (CAVD) involves progressive valve leaflet thickening and severe calcification, impairing leaflet motion. The in vitro calcification of primary rat, human, porcine and bovine aortic valve interstitial cells (VICs) is commonly employed to investigate CAVD mechanisms. However, to date, no published studies have utilised cell lines to investigate this process. The present study has therefore generated and evaluated the calcification potential of immortalized cell lines derived from sheep and rat VICs...
November 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203039/-vascular-calcification-in-pseudoxanthoma-elasticum-in-children
#11
A Dibi, N Mouane, E El Fahime, R Dafiri, A Bentahila
INTRODUCTION: Vascular calcifications are associated with several diseases that affect vascular connective tissue and skin and cause considerable morbidity and mortality. The prototype of these conditions is pseudoxanthoma elasticum. We report, in this study, 4 pediatric cases of vascular calcifications diagnosed as elastic pseudoxanthoma. OBSERVATIONS: These 4 children were 2-11 years old and presented variable clinical features. Vascular involvement and arterial hypertension was observed in all patients, skin involvement in 2 cases, gastrointestinal involvement in 2 cases, neurological impairment in one case, and cardiac involvement in one case...
December 2017: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29197601/ectopic-expression-of-pcsk9-by-smooth-muscle-cells-contributes-to-aortic-dissection
#12
Yasunori Iida, Hiroki Tanaka, Hideto Sano, Yuko Suzuki, Hideyuki Shimizu, Tetsumei Urano
BACKGROUND: Acute aortic dissection (AAD) is a common disease among the elderly. Although several risk factors of AAD have been reported, the molecular mechanism underlying AAD development remains to be elucidated. Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases LDL-cholesterol levels in blood by preventing its clearance. Therefore, PCSK9 inhibition is a promising therapeutic approach to treating cardiovascular diseases. The objective of this study was to elucidate the role of PCSK9 in the pathogenesis of AAD...
November 29, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29197521/high-phosphate-induced-downregulation-of-ppar%C3%AE-contributes-to-ckd-associated-vascular-calcification
#13
Liang Liu, Yong Liu, Ying Zhang, Xianjin Bi, Ling Nie, Chi Liu, Jiachuan Xiong, Ting He, Xinlin Xu, Yanlin Yu, Ke Yang, Jun Gu, Yunjian Huang, Jingbo Zhang, Zhiren Zhang, Bo Zhang, Jinghong Zhao
Medial arterial calcification associated with hyperphosphatemia is a main cause of cardiovascular mortality in patients with chronic kidney disease (CKD), but the mechanisms underlying high phosphate-induced vascular calcification remain largely unknown. Here, we observed a significant decrease in the expression of peroxisome proliferator-activated receptor-gamma (PPARγ) in calcified arteries both in CKD patients and in a mouse model of CKD with hyperphosphatemia. In vitro, high phosphate treatment led to a decreased expression of PPARγ in mouse vascular smooth muscle cells (VMSCs), accompanied by apparent osteogenic differentiation and calcification...
November 29, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29197225/4-aminopyridine-based-amide-derivatives-as-dual-inhibitors-of-tissue-non-specific-alkaline-phosphatase-and-ecto-5-nucleotidase-with-potential-anticancer-activity
#14
Sidra Hassan, Syeda Abida Ejaz, Aamer Saeed, Muddasar Shehzad, Shafi Ullah Khan, Joanna Lecka, Jean Sévigny, Ghulam Shabir, Jamshed Iqbal
Ecto-nucleotidase members i.e., ecto-5'-nucleotidase and alkaline phosphatase, hydrolyze extracellular nucleotides and play an important role in purinergic signaling. Their overexpression are implicated in a variety of pathological states, including immunological diseases, bone mineralization, vascular calcification and cancer, and thus they represent an emerging drug targets. In order to design potent and selective inhibitors, new derivatives of 4-aminopyridine have been synthesized (10a-10m) and their structures were established on the basis of spectral data...
November 21, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29196163/the-mir-182-sort1-axis-regulates-vascular-smooth-muscle-cell-calcification-in-vitro-and-in-vivo
#15
Zhanman Zhang, Wenhong Jiang, Han Yang, Qiuning Lin, Xiao Qin
Arterial calcification is a common feature of cardiovascular disease. Sortilin is involved in the development of atherosclerosis, but the specific mechanism is unclear. In this study, we established calcification models in vivo and in vitro by using vitamin D3 and β-glycerophosphate, respectively. In vivo, the expression of SORT1 was up-regulated and the expression of miR-182 was down-regulated in calcified arterial tissues. Meanwhile there was a negative correlation between SORT1 expression and miR-182 levels...
November 28, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29195902/indoxyl-sulfate-accelerates-vascular-smooth-muscle-cell-calcification-via-microrna-29b-dependent-regulation-of-wnt-%C3%AE-catenin-signaling
#16
Han Zhang, Jing Chen, Ziyan Shen, Yulu Gu, Linghan Xu, Jiachang Hu, Xiaoyan Zhang, Xiaoqiang Ding
Vascular calcification (VC) is a very common phenomenon in patients with chronic kidney disease(CKD) and it increases the incidence of cardiovascular disease and leads to high mortality in CKD patients. It has been reported that some microRNAs (miRs) play roles in vascular calcification as an epigenetic regulator. Indoxyl sulfate (IS) is a protein-bound uremic toxin which has been proven as one of the major risk factors of cardiovascular disease in CKD. Here we investigated whether microRNA-29b (miR-29b) is involved in IS-induced vascular calcification...
November 28, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29194699/ultrasonographic-findings-of-1385-adrenal-masses-a-retrospective-study-of-1319-benign-and-66-malignant-masses
#17
Xia Gong, Yifei Yu, Weiwei Zhan
OBJECTIVES: To evaluate the features of adrenal masses on ultrasonography and correlate the findings with the pathologic diagnoses to help distinguish benign from malignant adrenal lesions. METHODS: Ultrasonography was performed in 1363 patients with adrenal lesions. The following ultrasonographic parameters were recorded: size, shape, margin, echogenicity, echo texture, cystic necrosis, calcifications, and blood supply. The sensitivity and specificity of aggressive features for predicting malignancy were calculated...
December 1, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29191923/sortilin-and-its-multiple-roles-in-cardiovascular-and-metabolic-diseases
#18
REVIEW
Claudia Goettsch, Mads Kjolby, Elena Aikawa
Cardiovascular disease is a leading cause of morbidity and mortality in the Western world. Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the genome-wide association studies that have revealed an association between cardiovascular diseases and the 1p13 locus that encodes sortilin. Emerging evidence suggests a significant role of sortilin in the pathogenesis of vascular and metabolic diseases. This includes type II diabetes mellitus via regulation of insulin resistance, atherosclerosis through arterial wall inflammation and calcification, and dysregulated lipoprotein metabolism...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29182961/matrix-stiffness-determines-the-phenotype-of-vascular-smooth-muscle-cell-in%C3%A2-vitro-and-in%C3%A2-vivo-role-of-dna-methyltransferase-1
#19
Si-An Xie, Tao Zhang, Jin Wang, Feng Zhao, Yun-Peng Zhang, Wei-Juan Yao, Sung Sik Hur, Yi-Ting Yeh, Wei Pang, Li-Sha Zheng, Yu-Bo Fan, Wei Kong, Xian Wang, Jeng-Jiann Chiu, Jing Zhou
Cells perceive the physical cues such as perturbations of extracellular matrix (ECM) stiffness, and translate these stimuli into biochemical signals controlling various aspects of cell behavior, which contribute to the physiological and pathological processes of multiple organs. In this study, we tested the hypothesis that during arterial stiffening, vascular smooth muscle cells (SMCs) sense the increase of ECM stiffness, which modulates the cellular phenotype through the regulation in DNA methyltransferases 1 (DNMT1) expression...
November 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/29181216/endovascular-repair-with-a-stent-graft-in-a-patient-with-aortoduodenal-fistula-after-radiation-therapy
#20
Kazuhiko Morikawa, Hirokazu Ashida, Yosuke Nozawa, Kenji Motohashi, Takao Igarashi, Hiroya Ojiri, Yuji Kanaoka, Takao Ohki
Primary aortoduodenal fistula (ADF) is a direct communication between the abdominal aorta and the gastrointestinal tract without any previous vascular intervention and represents a rare but critical cause of repeated and massive gastrointestinal bleeding. Primary ADF often occurs as a result of atherosclerotic aneurysm and infection, but ADF involving a normal-size aorta is rare; furthermore, ADF related to radiation therapy is extremely rare. We present the case of a 56-year-old man with a history of bowel obstruction due to radiation enteritis who was admitted with severe hematemesis and hemorrhagic shock...
2017: Case Reports in Radiology
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