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Vascular calcifications

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https://www.readbyqxmd.com/read/29471680/proteomic-profiling-of-extracellular-vesicles-released-from-vascular-smooth-muscle-cells-during-initiation-of-phosphate-induced-mineralization
#1
Sandeep C Chaudhary, Sana Khalid, Victoria Smethurst, Daisy Monier, James Mobley, Alexis Huet, James F Conway, Dobrawa Napierala
Elevated serum phosphate is one of the major factors contributing to vascular calcification. Studies suggested that extracellular vesicles released from vascular smooth muscle cells significantly contribute to the initiation and progression of this pathology. Recently, we have demonstrated that elevated phosphate stimulates release of extracellular vesicles from osteogenic cells at the initiation of the mineralization process. Here, we used MOVAS cell line as an in vitro model of vascular calcification to examine whether vascular smooth muscle cells respond to high phosphate levels in a similar way and increase formation of extracellular vesicles...
February 22, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29467541/inhibition-of-endo-lysosomal-function-exacerbates-vascular-calcification
#2
Yujun Cai, Xue-Lin Wang, Alyssa M Flores, Tonghui Lin, Raul J Guzman
Vascular calcification is a pathologic response to mineral imbalances and is prevalent in atherosclerosis, diabetes mellitus, and chronic kidney disease. When located in the media, it is highly associated with increased cardiovascular morbidity and mortality, particularly in patients on dialysis. Vascular calcification is tightly regulated and controlled by a series of endogenous factors. In the present study, we assess the effects of lysosomal and endosomal inhibition on calcification in vascular smooth muscle cells (VSMCs) and aortic rings...
February 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29466936/utilization-and-in-hospital-outcomes-associated-with-atherectomy-in-the-treatment-of-peripheral-vascular-disease-an-observational-analysis-from-the-national-inpatient-sample
#3
Rajkumar Doshi, Evan Shlofmitz, Perwaiz Meraj
Objective Percutaneous revascularization for patients with peripheral arterial disease has become a treatment of choice for many symptomatic patients. The presence of severe arterial calcification presents many challenges for successful revascularization. Atherectomy is an adjunctive treatment option for patients with severe calcification undergoing percutaneous intervention. We sought to analyze the impact of atherectomy on in-hospital outcomes, length of stay, and cost in the percutaneous treatment of peripheral arterial disease...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29461888/some-unanticipated-consequences-of-early-cardiac-catheterization-insights-into-pulmonary-pathophysiology
#4
John B West
One of the most interesting unanticipated findings by André Cournand and Dickinson Richards in their groundbreaking studies of cardiac catheterization was the very low pressure in the normal pulmonary circulation. At the time, in the 1940s, the significance of this was not appreciated. For example, in their speeches at the Nobel Prize ceremony, neither of these laureates referred to the low pressure, although they did discuss other features of the pulmonary circulation. It was up to the cardiologist, William Dock, to point out that these low pressures implied a very uneven distribution of blood flow in the lung, and in particular that in the normal upright lung, the blood flow to the apex would be extremely small...
February 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29461604/a-novel-ultrasound-based-vascular-calcification-score-calcs-to-detect-subclinical-atherosclerosis
#5
R Flore, M A Zocco, M E Ainora, C Fonnesu, A Nesci, A Gasbarrini, F R Ponziani
OBJECTIVE: To quantify non-coronary vascular calcifications (VC) in asymptomatic patients at low-intermediate cardiovascular risk by a new color Doppler ultrasound (DUS)-based score (the carotid, aortic, lower limbs calcium score, CALCs), and to correlate this score with classical parameters associated with cardiovascular risk [carotid intima media thickness (IMT), and arterial stiffness (AS)]. PATIENTS AND METHODS: All consecutive asymptomatic patients who underwent a screening DUS of non-coronary circulation were evaluated and patients at low-intermediate cardiovascular risk were selected according to Framingham risk score (FRS)...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29457415/-preliminary-study-of-intervention-in-effect-of-bushen-huoxue-recipe-on-calcification-of-lumbar-vertebra-cartilage-endplate-of-the-aging-gerbils
#6
Li-Guo Zhu, Ping Zhang, Qing-Hui Song, Wan-Qiang Zhang, Hong-Wei Zhu, Li-Ping Yang, Yan Zhu, Yuan Wang, Ling-Hui Li
OBJECTIVE: To study the effect of Bushen Huoxue decoction on calcification of cartilage endplate in lumbar vertebrae. METHODS: Six healthy male gerbils with 2-month-old were selected as normal control group, and 24 7-month-old healthy male gerbils were fed to 12-month-old to establish the aged gerbil model. Thirty gerbils were randomly divided into five groups as follow: the normal control group ( n =6), model group ( n =6, normal saline 4 ml/kg, intragastric 30 d), Bushen Huoxue low dose group( n =6, 1...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29455498/-radiologic-observation-of-the-blood-supply-changes-around-the-knee-with-osteoarthritis
#7
Jin-Song Liu, Zhi-Yao Li
OBJECTIVE: To compare blood supply changes around the knee joint between normal and osteoarthritis knee. METHODS: From June 2014 to June 2015, 30 patients with knee osteoarthritis and 30 healthy adults were recruited. In osteoarthritis group, there were 9 males and 21 females, with a mean age of (65.967±7.132) years old(ranged, 53 to 82 years old), and the mean arterial pressure was(93.462±7.633) mmHg. In control group, there were 9 males and 21 females, with a mean age of (62...
August 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29452856/generalized-cardiovascular-disease-on-a-preoperative-ct-scan-is-predictive-for-anastomotic-leakage-after-esophagectomy
#8
Alicia S Borggreve, Lucas Goense, Peter S N van Rossum, Richard van Hillegersberg, Pim A de Jong, Jelle P Ruurda
BACKGROUND: Recent studies demonstrated that calcification of arteries supplying the gastric tube is associated with anastomotic leakage after esophagectomy. However, it remains unclear whether this association only derives from local flow limitations, or generalized vascular disease as well. The purpose of this study was to determine whether calcification throughout the entire cardiovascular system is associated with anastomotic leakage. METHODS: Consecutive patients who underwent an esophagectomy with gastric tube reconstruction and cervical anastomosis for esophageal cancer were analyzed...
February 2, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29452721/use-of-the-gore-tigris-vascular-stent-in-advanced-femoropopliteal-peripheral-arterial-disease
#9
Pierleone Lucatelli, Marco Cini, Giulio Tommasino, Antonio Benvenuti, Giulia Guaccio, Stefano Bascetta, Eugenio Neri, Carmelo Ricci
PURPOSE: To prospectively evaluate the safety and efficacy of using the Tigris vascular stent (Gore, Flagstaff, Arizona) alone or in combination with the Viabahn stent (Gore) for revascularizing femoropopliteal Trans-Atlantic Intersociety Consensus (TASC) type B-D lesions with varying degrees of calcification. MATERIALS AND METHODS: Patients with Rutherford stage ≥ 3 and TASC type ≥ B were included in the study. From January 2015 to April 2017, 31 segments in 31 patients (21 men, ovarall mean age 73...
February 13, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29445837/alkaline-phosphatases-in-the-complex-chronic-kidney-disease-mineral-and-bone-disorders
#10
Jordi Bover, Pablo Ureña, Armando Aguilar, Sandro Mazzaferro, Silvia Benito, Víctor López-Báez, Alejandra Ramos, Iara daSilva, Mario Cozzolino
Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple metabolic processes (from many molecules such as proteins, nucleotides, or pyrophosphate). Therefore, APs are important for bone mineralization but paradoxically they can also be deleterious for other processes, such as vascular calcification and the increasingly known cross-talk between bone and vessels. A proper balance between beneficial and harmful activities is further complicated in the context of chronic kidney disease (CKD)...
February 14, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29445095/granzyme-b-deficiency-promotes-osteoblastic-differentiation-and-calcification-of-vascular-smooth-muscle-cells-in-hypoxic-pulmonary-hypertension
#11
Min Mao, Min Zhang, Anqi Ge, Xin Ge, Rui Gu, Chen Zhang, Yao Fu, Jiayin Gao, Xiaoying Wang, Yang Liu, Daling Zhu
Calcification is a major risk factor for vascular integrity. This pathological symptom and the underlying mechanisms in hypoxic pulmonary artery hypertension remain elusive. Here we report that pulmonary vascular medial calcification is elevated in pulmonary artery hypertension models as a result of an osteoblastic phenotype change of pulmonary arterial smooth muscle cells induced by hypoxia. Notably, inhibiting store-operated calcium channels significantly decreased osteoblastic differentiation and calcification of pulmonary arterial smooth muscle cells under hypoxia...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29443425/long-term-atherosclerotic-vascular-disease-risk-and-prognosis-in-elderly-women-with-abdominal-aortic-calcification-on-lateral-spine-images-captured-during-bone-density-testing-a-prospective-study
#12
Joshua R Lewis, John T Schousboe, Wai H Lim, Germaine Wong, Kevin E Wilson, Kun Zhu, Peter L Thompson, Douglas P Kiel, Richard L Prince
Lateral spine images are captured using bone densitometers for vertebral fracture assessment (VFA) in older women. Abdominal aortic calcification (AAC) is commonly seen on these images however the long-term prognosis in women with AAC remains uncertain. In a prospective study of 1,052 community-dwelling ambulant Caucasian women over 70 years AAC24 scores were calculated from digital lateral spine images captured during bone density testing in 1998 or 1999. Cardiovascular risk factors were assessed in 1998 while 14...
February 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29442454/higher-concentrations-of-osteoprotegerin-in-type-1-diabetic-patients-are-related-to-retinopathy-results-from-the-pozna%C3%A5-prospective-study
#13
Agata Grzelka, Dariusz Naskręt, Aleksandra Araszkiewicz, Aleksandra Uruska, Małgorzata Wegner, Dorota Zozulińska-Ziółkiewicz
BACKGROUND: Osteoprotegerin (OPG) is an arterial calcification marker which has been associated with vascular damage. Elevated OPG concentrations associated with low-grade inflammatory processes are found in diabetic subjects. OBJECTIVES: The aim of the study was to assess concentrations of OPG in relation to the presence of diabetic complications in patients with diabetes type 1 (DM 1) participating in the Poznań Prospective Study (PoProStu). MATERIAL AND METHODS: The study included 74 patients with DM1 (48 men) with a median age of 39 years (interquartile range [IQR]: 34-43) and a median 15-year history (IQR: 14-16) of diabetes, who were participants in the PoProStu...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29442043/satb1-promotes-osteoclastogenesis-by-recruiting-cbp-to-upregulate-mir-223-expression-in-chronic-kidney-disease-mineral-and-bone-disorder
#14
Jun Li, Guangqun Xing, Lili Zhang, Jinchun Shang, Yuan Li, Chunmei Li, Fen Tian, Xiangdong Yang
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a complex disease which is associated with alterations of bone and mineral metabolism. miR-223 is implicated in both vascular calcification and osteoporosis. In the present study, we investigated the influence of Stab1 gene on miRNA-223 expression in osteoclastogenesis. Differentiation of monocyte/macrophage precursors was assessed by using RAW264.7 cells and peripheral blood mononuclear cells (PBMC). TRAP activity and bone resorption were used to measure osteoclast activity...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29440923/managing-hyperparathyroidism-in-hemodialysis-role-of-etelcalcetide
#15
REVIEW
Keith E Eidman, James B Wetmore
Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Additional clinical effects include reductions in circulating levels of phosphate and FGF-23 and an improved profile of markers of bone turnover...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29436118/cortistatin-inhibits-arterial-calcification-in-rats-via-gsk3%C3%AE-%C3%AE-catenin-and-pkc-signaling-but-not-jnk-signaling
#16
Yue Liu, Fang Lin, Yu Fu, Wenjia Chen, Wenxiu Liu, Jinyu Chi, Xiaohui Zhang, Xinhua Yin
AIM: Cortistatin (CST) is a newly discovered endogenous active peptide that exerts protective effects on the cardiovascular system. However, the relationship between CST and aortic calcification and the underlying mechanism remain obscure. Therefore, we investigated effects of CST on aortic calcification and its signaling pathways. METHODS: Calcium content and alkaline phosphatase (ALP) activity were measured using the o-cresolphthalein colorimetric method and ALP assay kit, respectively...
February 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29434762/parathyroid-hormone-promotes-osteoblastic-differentiation-of-endothelial-cells-via-the-extracellular-signal-regulated-protein-kinase-1-2-and-nuclear-factor-%C3%AE%C2%BAb-signaling-pathways
#17
Zhi-Yuan Cheng, Ting Ye, Qiu-Yang Ling, Ting Wu, Gang-Yong Wu, Gang-Jun Zong
Vascular calcification (VC) occurs in patients with chronic kidney disease (CKD) and contributes to cardiovascular dysfunction and mortality. Parathyroid hormone (PTH) is a crucial regulator of VC. High PTH serum levels constitute as a major risk factor for patients with CKD. However, the effect and mechanism of PTH on osteoblastic differentiation in endothelial cells have not been fully elucidated. In the present study, the role of PTH in VC was investigated using an in vitro calcification model. Endothelial cells were stimulated with PTH in the femto- to picomolar range...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434184/cyclosporin-a-aggravates-calcification-of-vascular-smooth-muscle-cells-under-high-glucose-conditions-with-a-calcifying-medium
#18
Dae Hee Kim, Keon Cheol Lee, Sang Youb Han
BACKGROUND Vascular calcification (VC) progresses substantially even after kidney transplantation, and is a predictor of morbidity and mortality. However, the effect of cyclosporin A (CsA) on VC has not been reported in diabetic kidney transplant patients. In this study, we evaluated the effect of CsA on the VC of mouse vascular smooth muscle cells (VSMCs) under high glucose (HG). MATERIAL AND METHODS To demonstrate the effect of CsA (1.0 µmol/L) and HG (30 mM) in the induction of the VC of the VSMCs, we determined alkaline phosphatase (ALP) activity, microscopic morphology of calcification, the expressions of the calcification and inflammation-related genes, and the intracellular calcium concentrations in VSMCs...
February 13, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29434174/macrophages-highly-express-carbonic-anhydrase-2-and-play-a-significant-role-in-demineralization-of-the-ectopic-calcification
#19
Agian Jeffilano Barinda, Koji Ikeda, Ken-Ichi Hirata, Noriaki Emoto
Vascular calcification is an important risk factor for cardiovascular disease, and is closely associated with all-cause mortality. Recently, it has been revealed that vascular calcification is not a passive precipitation of circulating minerals, but is a process actively regulated through machinery similar to bone formation. During the bone remodeling, osteoclasts execute the bone resorption by releasing hydrogen ions to dissolve minerals; however, molecular mechanisms underlying decalcification of ectopically calcified lesions remain largely unknown...
October 16, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/29432933/arterial-stiffening-and-thickening-in-patients-with-pseudoxanthoma-elasticum
#20
Guido Kranenburg, Frank L J Visseren, Gert Jan de Borst, Pim A de Jong, Wilko Spiering
BACKGROUND AND AIMS: Patients with pseudoxanthoma elasticum (PXE), a monogenetic calcification disease, are at high vascular risk. Although the precise arterial phenotype remains unestablished, it is hypothesized that PXE predominantly affects the medial arterial layer leading to arterial stiffening. We aimed to test this hypothesis by measuring arterial wall characteristics in PXE and comparisons with the general population and diabetes mellitus type 2 (DM2), a condition typically associated with mixed intimal and medial arterial disease...
February 9, 2018: Atherosclerosis
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