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https://www.readbyqxmd.com/read/28217544/assessment-of-knowledge-attitude-and-practices-on-fixed-dose-combinations-among-postgraduate-dental-students
#1
Narayana R Vinnakota, V Krishna, V Viswanath, Zaheer Ahmed, Kamal S Shaik, Naveen K Boppana
AIM: To assess the knowledge, attitude, and practices of fixed dose combination drugs among postgraduate dental students. MATERIALS AND METHODS: A cross-sectional study was carried out among postgraduate dental students of dental colleges in coastal Andhra Pradesh. Three colleges were randomly selected and students of all the three years were included. Data was collected from the specialities of oral medicine and radiology, oral surgery, endodontics, pedodontics, periodontics, and public health dentistry...
December 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28214737/identification-of-non-steroidal-anti-inflammatory-drug-use-disorder-a-case-report
#2
Margo E Godersky, Laura K Vercammen, Alicia S Ventura, Alexander Y Walley, Richard Saitz
Commonly used for analgesic and anti-inflammatory effects, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most frequently used medications in the world. In spite of their prevalence, reports of NSAID misuse and NSAID use disorder are uncommon. This case report describes a research participant who met criteria for DSM-5 moderate substance use disorder based on her use of prescribed ibuprofen as assessed by the validated Mini International Neuropsychiatric Interview (MINI). This case demonstrates that the DSM-5 criteria within the MINI can be applied to diagnose an NSAID use disorder...
February 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28214648/toxicity-degradation-and-metabolic-fate-of-ibuprofen-on-freshwater-diatom-navicula-sp
#3
Tengda Ding, Mengting Yang, Junmin Zhang, Bo Yang, Kunde Lin, Juying Li, Jay Gan
Ibuprofen (IBU) is one of the most widely used and frequently detected human pharmaceuticals in aquatic environment. However, the toxicity of IBU on diatom and its fate remain still unkown. In the present study, the toxicity of IBU on the diatom was evaluated by the algal growth rate, the chlorophyll-a and carotenoids contents. The degradation of IBU including in particular the potential for the formation of incomplete degradation products was also explored. Biochemical characteristics of Navicula sp. were significantly inhibited at IBU concentrations up to 50mgL(-1) after 10days of exposure...
February 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28212300/amorphous-amorphous-phase-separation-in-api-polymer-formulations
#4
Christian Luebbert, Fabian Huxoll, Gabriele Sadowski
The long-term stability of pharmaceutical formulations of poorly-soluble drugs in polymers determines their bioavailability and therapeutic applicability. However, these formulations do not only often tend to crystallize during storage, but also tend to undergo unwanted amorphous-amorphous phase separations (APS). Whereas the crystallization behavior of APIs in polymers has been measured and modeled during the last years, the APS phenomenon is still poorly understood. In this study, the crystallization behavior, APS, and glass-transition temperatures formulations of ibuprofen and felodipine in polymeric PLGA excipients exhibiting different ratios of lactic acid and glycolic acid monomers in the PLGA chain were investigated by means of hot-stage microscopy and DSC...
February 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211343/immediate-reactions-to-more-than-1-nsaid-must-not-be-considered-cross-hypersensitivity-unless-tolerance-to-asa-is-verified
#5
D Pérez-Alzate, J A Cornejo-García, N Pérez-Sánchez, I Andreu, A García-Moral, J A Agúndez, J Bartra, I Doña, M J Torres, M Blanca, N Blanca-López, G Canto
BACKGROUND AND OBJECTIVES: Individuals who develop drug hypersensitivity reactions (DHRs) to chemically unrelated nonsteroidal anti-inflammatory drugs (NSAIDs) are considered cross-hypersensitive. The hallmark for this classification is that the patient presents a reaction after intake of or challenge with acetylsalicylic acid (ASA). Whether patients react to 2 or more NSAIDs while tolerating ASA remains to be studied (selective reactions, SRs). Objective: To identify patients with SRs to 2 or more NSAIDs including strong COX-1 inhibitors...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28211337/enhanced-electrochemical-degradation-of-ibuprofen-in-aqueous-solution-by-ptru-alloy-catalyst
#6
Chiung-Fen Chang, Tsan-Yao Chen, Ching-Ju Monica Chin, Yu-Tsun Kuo
Electrochemical advanced oxidation processes (EAOPs) regarded as a green technology for aqueous ibuprofen treatment was investigated in this study. Multi-walled carbon nanotubes (MWCNTs), Pt nanoparticles (Pt NPs), and PtRu alloy, of which physicochemical properties were characterized by XRD and X-ray absorption spectroscopy, were used to synthesize three types of cheap and effective anodes based on commercial conductive glass. Furthermore, the operating parameters, such as the current densities, initial concentrations, and solution pH were also investigated...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28208879/carbamazepine-induced-life-threatening-stevens-johnson-syndrome-and-agranulocytosis-the-maiden-case
#7
A Avinash, V Mohanbabu Amberkar, Sushil Kiran Kunder, Sharath Madhyastha, K Meenakumari
Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28199939/sorption-and-desorption-of-selected-non-steroidal-anti-inflammatory-drugs-in-an-agricultural-loam-textured-soil
#8
Y Zhang, G W Price, R Jamieson, D Burton, K Khosravi
Non-steroidal, anti-inflammatory drugs (NSAIDs) are widely used pharmaceutical products with analgesic and anti-inflammatory effects that are consistently detected in municipal wastewater systems and in municipal biosolids. Land application of biosolids and irrigation with reclaimed wastewater introduces these compounds into agricultural environments, which is an emerging issue of concern for ecosystem health. In this study, the sorption-desorption behaviour of four commonly consumed NSAIDs, including naproxen (NPX), ibuprofen (IBU), ketoprofen (KTF), and diclofenac (DCF), was examined in a loam textured soil exposed to either an individual-compound or a mixture of the four NSAIDs...
February 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28199788/development-of-fluorescence-surrogates-to-predict-the-photochemical-transformation-of-pharmaceuticals-in-wastewater-effluents
#9
Shuwen Yan, Bo Yao, Lushi Lian, Xinchen Lu, Shane A Snyder, Rui Li, Weihua Song
The photochemical transformation of pharmaceutical and personal care products (PPCPs) in wastewater effluents is an emerging concern for environmental scientists. In the current study, the photodegradation of 29 PPCPs was examined in effluents under simulated solar irradiation. Direct photodegradation, triplet state effluent organic matter (3EfOM*)-mediated and hydroxyl radical (HO•)-mediated degradation are three major pathways in the removal process. With the photodegradation of trace levels of PPCPs, the excitation-emission matrix (EEM) fluorescence intensities of the effluents were also gradually reduced...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28198617/cometabolic-enzymatic-transformation-of-organic-micropollutants-under-methanogenic-conditions
#10
Lorena Gonzalez-Gil, Marta Carballa, Juan M Lema
Anaerobic digestion (AD) has been shown to have the biological potential to decrease the concentrations of several organic micropollutants (OMPs) from sewage sludge. However, the mechanisms and factors behind these biotransformations, which are essential for elucidating the possible transformation products and to foster the complete removal of OMPs via operational strategies, remain unclear. Therefore, this study investigated the transformation mechanisms of 20 OMPs during the methanogenic step of AD with a focus on the role of acetate kinase (AK), which is a key enzyme in methane production...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28192663/surfactant-free-solid-dispersions-of-hydrophobic-drugs-in-an-amorphous-sugar-matrix-dried-from-an-organic-solvent
#11
Koji Takeda, Yuto Gotoda, Daichi Hirota, Fumihiro Hidaka, Tomo Sato, Tsutashi Matsuura, Hiroyuki Imanaka, Naoyuki Ishida, Koreyoshi Imamura
The technique for homogeneously dispersing hydrophobic drugs in a water-soluble solid matrix (solid dispersion) is a subject that has been extensively investigated in the pharmaceutical industry. Herein, a novel technique for dispersing a solid, without the need to use a surfactant, is reported. A freeze-dried amorphous sugar sample was dissolved in an organic solvent, that contained a soluble model hydrophobic component. The suspension of the sugar and the model hydrophobic component was vacuum foam dried to give a solid powder...
February 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28189026/mass-spectrometry-based-in%C3%A2-vitro-assay-investigations-on-the-transformation-of-pharmaceutical-compounds-by-oxidative-enzymes
#12
Lara F Stadlmair, Thomas Letzel, Jörg E Drewes, Johanna Graßmann
The ubiquitous presence of trace organic chemicals in wastewater and surface water leads to a growing demand for novel removal technologies. The use of isolated enzymes has been shown to possess the capability for a targeted application but requires a clearer mechanistic understanding. In this study, the potential of peroxidase from horseradish (HRP) and laccase from Pleurotus ostreatus (LccPO) to transform selected trace organic chemicals was studied using mass spectrometry (MS)-based in vitro enzyme assays...
February 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28188341/evaluation-of-transcriptomic-signature-as-a-valuable-tool-to-study-drug-induced-cholestasis-in-primary-human-hepatocytes
#13
Céline Parmentier, Philippe Couttet, Armin Wolf, Thomas Zaccharias, Bruno Heyd, Philippe Bachellier, Marianne Uteng, Lysiane Richert
Primary human hepatocyte (PHH) sandwich cultures from five different donors were daily exposed to cyclosporine A (CsA), ibuprofen (IBU), chlorpromazine (CPZ), amiodarone (AMI) and paracetamol (APAP) at their respective Cmax (total) for short-term (1-3 days) and long-term treatment (14 days). Whole genome mRNA profiles (34,693 genes in total) were conducted using an Illumina microarray platform. The impact of compound treatments on gene signatures involved in liver differentiation, cholestasis and in bile acid homeostasis was evaluated...
February 10, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28187390/the-fate-of-pharmaceuticals-and-personal-care-products-ppcps-endocrine-disrupting-contaminants-edcs-metabolites-and-illicit-drugs-in-a-wwtw-and-environmental-waters
#14
Edward Archer, Bruce Petrie, Barbara Kasprzyk-Hordern, Gideon M Wolfaardt
A large number of emerging contaminants (ECs) are known to persist in surface waters, and create pressure on wastewater treatment works (WWTW) for their effective removal. Although a large database for the levels of these pollutants in water systems exist globally, there is still a lack in the correlation of the levels of these pollutants with possible long-term adverse health effects in wildlife and humans, such as endocrine disruption. The current study detected a total of 55 ECs in WWTW influent surface water, 41 ECs in effluent, and 40 ECs in environmental waters located upstream and downstream of the plant...
January 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28185778/efficacy-of-repeated-courses-of-ibuprofen-in-the-closure-of-patent-ductus-arteriosus-in-premature-infants
#15
EDITORIAL
Ting-An Yen, Ching-Chia Wang
No abstract text is available yet for this article.
January 19, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28183664/graphene-oxide-and-creatine-phosphate-disodium-dual-template-directed-synthesis-of-go-hydroxyapatite-and-its-application-in-drug-delivery
#16
Chengli Yao, Jinmiao Zhu, Anjian Xie, Yuhua Shen, Hongying Li, Bin Zheng, Yanxin Wei
In this study, graphene oxide and creatine phosphate disodium acted as dual template and was employed to synthesize graphene oxide (GO)/hydroxyapatite (HA) hybrids as drug carriers. In the rapid preparation of GO/HA hybrids, creatine phosphate disodium salt (CPDS) severed as a phosphorus source and graphene oxide acted as a template in aqueous solution. The effects of the reaction temperature, time and pH value of the aqueous solution on the morphology of the product were investigated. The result showed that the hydrolysis of CPDS under hydrothermal condition played an important role in the formation of hierarchical hollow GO/HA hybrids...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28178024/the-effects-of-curcuminoids-on-musculoskeletal-pain-a-systematic-review
#17
Andrew Gaffey, Helen Slater, Kylie Porritt, Jared M Campbell
BACKGROUND: Western countries are increasingly using complementary and alternative medicine (CAM) to assist with relieving ailments. Turmeric, from the ginger family Zingiberaceae, has a history of use for medicinal purposes. The polyphenols found in turmeric (curcuminoids) have demonstrated anti-inflammatory and pain relieving properties. With the use of CAMs increasing, it is important for the effectiveness of curcuminoids to be established. OBJECTIVES: To identify the effectiveness of the use of curcuminoids for the amelioration of musculoskeletal pain...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28156624/a-study-of-discrepancy-between-laboratory-calculated-and-weight-based-glomerular-filtration-rate-gfr-as-a-marker-of-renal-function-in-a-palliative-care-population
#18
Miriam Colleran
: 58 Background: Renal function is important in a palliative care population and can impact on frequently-used medications including chemotherapeutic agents, opioids, non-steroidal anti-inflammatory drugs and neuropathic agents. In local practice, estimated glomerular filtration rate (eGFR), calculated on a presumed weight of 70kg, is displayed in laboratory results. However, the weight of palliative patients varies considerably, for example, due to cancer cachexia or malabsorption and a considerable population weigh less than 70kg...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28153724/pharmacological-assessment-of-ibuprofen-arginate-on-platelet-aggregation-and-colon-cancer-cell-killing
#19
B Ahmetaj-Shala, A Tesfai, C Constantinou, R Leszczynski, M V Chan, H Gashaw, G Galaris, S Mazi, T D Warner, N S Kirkby, J A Mitchell
Nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, are amongst the most commonly used medications and produce their anti-inflammatory and analgesic benefits by blocking cyclooxygenase (COX)-2. These drugs also have the potential to prevent and treat cancer and some members of the class including ibuprofen can produce anti-platelet effects. Despite their utility, all NSAIDs are associated with increased risk of cardiovascular side effects which our recent work suggests could be mediated by increased levels of the endogenous NO synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) leading to reduced endothelial NOS activity and associated endothelial cell dysfunction...
January 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28153413/model-predicted-occurrence-of-multiple-pharmaceuticals-in-swedish-surface-waters-and-their-flushing-to-the-baltic-sea
#20
C Lindim, J van Gils, I T Cousins, R Kühne, D Georgieva, S Kutsarova, O Mekenyan
An exposure assessment for multiple pharmaceuticals in Swedish surface waters was made using the STREAM-EU model. Results indicate that Metformin (27 ton/y), Paracetamol (6.9 ton/y) and Ibuprofen (2.33 ton/y) were the drugs with higher amounts reaching the Baltic Sea in 2011. 35 of the studied substances had more than 1 kg/y of predicted flush to the sea. Exposure potential given by the ratio amount of the drug exported to the sea/amount emitted to the environment was higher than 50% for 7 drugs (Piperacillin, Lorazepam, Metformin, Hydroxycarbamide, Hydrochlorothiazide, Furosemide and Cetirizine), implying that a high proportion of them will reach the sea, and below 10% for 27 drugs, implying high catchment attenuation...
January 30, 2017: Environmental Pollution
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