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https://www.readbyqxmd.com/read/29346641/uncovering-behavioural-diversity-amongst-high-strength-pseudomonas-spp-surfactants-at-the-limit-of-liquid-surface-tension-reduction
#1
Kamaluddeen Kabir, Yusuf Y Deeni, Simona M Hapca, Luke Moore, Andrew J Spiers
Bacterial bio-surfactants have a wide range of biological functions and biotechnological applications. Previous analyses had suggested a limit to their reduction of aqueous liquid surface tensions (γMin), and here we confirm this in an analysis of 25 Pseudomonas spp. strains isolated from soil which produce high-strength surfactants that reduce surface tensions to 25.2 ± 0.1-26.5 ± 0.2 mN.m-1 (the surface tension of sterile growth medium and pure water was 52.9 ± 0.4 mN.m-1 and 72.1 ± 1.2 mN.m-1, respectively)...
January 16, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29345955/investigation-of-polymer-surfactant-interactions-and-their-impact-on-itraconazole-solubility-and-precipitation-kinetics-for-developing-spray-dried-amorphous-solid-dispersions
#2
Tanvi Mahesh Deshpande, Helen Shi, John Pietryka, Stephen W Hoag, Ales Medek
Methods were developed to systematically screen different polymer-surfactant combinations for the purpose of enhancing amorphous active pharmaceutical ingredient (API) solubility while maintaining its physical stability. Itraconazole (ITZ) was chosen as the model API mostly due to its low aqueous solubility. Special attention was paid to determine the effect of a reduction in the critical micelle concentration (CMC) by specific polymer/surfactant combinations on the ITZ solubility and physical stability. However, only a slight correlation was actually found...
January 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29345420/integration-of-gas-enhanced-oil-recovery-in-multiphase-fermentations-for-the-microbial-production-of-fuels-and-chemicals
#3
Susana Pedraza-de la Cuesta, Lore Keijzers, Luuk A M van der Wielen, Maria C Cuellar
In multiphase fermentations where the product forms a second liquid phase or where solvents are added for product extraction, turbulent conditions disperse the oil phase as droplets. Surface-active components (SACs) present in the fermentation broth can stabilize the product droplets thus forming an emulsion. Breaking this emulsion increases process complexity and consequently the production cost. In previous works, it has been proposed to promote demulsification of oil/supernatant emulsions in an off-line batch bubble column operating at low gas flow rate...
January 18, 2018: Biotechnology Journal
https://www.readbyqxmd.com/read/29345196/surfactant-protein-c-dampens-inflammation-by-decreasing-jak-stat-activation-during-lung-repair
#4
Huiyan Jin, Andrzej K Ciechanowicz, Alanna R Kaplan, Lin Wang, Ping Xia Zhang, Yi-Chien Lu, Rachel E Tobin, Brooke A Tobin, Lauren Cohn, Caroline J Zeiss, Patty J Lee, Emanuela M Bruscia, Diane S Krause
Surfactant Protein C (SPC), a key component of pulmonary surfactant, also plays a role in regulating inflammation. SPC deficiency in patients and mouse models is associated with increased inflammation and delayed repair, but the key drivers of SPC-regulated inflammation in response to injury are largely unknown. This study focuses on a new mechanism of SPC as an anti-inflammatory molecule using SPC-TK/SPC-KO (surfactant protein C-thymidine kinase/surfactant protein C knockout) mice, which represent a novel sterile injury model that mimics clinical acute respiratory distress syndrome (ARDS)...
January 18, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29344811/metabolic-evolution-and-a-comparative-omics-analysis-of-corynebacterium-glutamicum-for-putrescine-production
#5
Zhen Li, Yu-Ping Shen, Xuan-Long Jiang, Li-Shen Feng, Jian-Zhong Liu
Putrescine is widely used in the industrial production of bioplastics, pharmaceuticals, agrochemicals, and surfactants. Because the highest titer of putrescine is much lower than that of its precursor L-ornithine reported in microorganisms to date, further work is needed to increase putrescine production in Corynebacterium glutamicum. We first compared 7 ornithine decarboxylase genes and found that the Enterobacter cloacae ornithine decarboxylase gene speC1 was most suitable for putrescine production in C. glutamicum...
January 17, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29343956/essential-oil-loaded-lipid-nanoparticles-for-wound-healing
#6
Francesca Saporito, Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Cinzia Boselli, Antonia Icaro Cornaglia, Barbara Mannucci, Pietro Grisoli, Barbara Vigani, Franca Ferrari
Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29343818/a-surfactant-polymer-dressing-potentiates-antimicrobial-efficacy-in-biofilm-disruption
#7
Piya Das Ghatak, Shomita S Mathew-Steiner, Priyanka Pandey, Sashwati Roy, Chandan K Sen
A 100% water-soluble surfactant polymer dressing (SPD) that is bio-compatible and non-ionic has been reported to improve wound closure in preliminary clinical studies. The mechanism of action of SPD in wound healing remains unclear. Biofilm infection is a significant problem that hinders proper wound closure. The objective of this study was to characterize the mechanism of action of SPD inhibition of bacterial biofilm development. Static biofilms (48 h) of the primary wound pathogens Pseudomonas aeruginosa (PA01), Staphylococcus aureus (USA300) were grown on polycarbonate membranes and treated with SPD with and without antibiotics for an additional 24 h...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343729/drug-self-assembly-for-synthesis-of-highly-loaded-antimicrobial-drug-silica-particles
#8
Cameron A Stewart, Yoav Finer, Benjamin D Hatton
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343451/biochemical-characterization-of-halophilic-alkalithermophilic-amylopullulanase-puld7-and-truncated-amylopullulanases-puld7%C3%AE-n-and-puld7%C3%AE-c
#9
Noha M Mesbah, Juergen Wiegel
A pullulanase, PulD7, was identified in the genome of the halophilic, alkalithermophilic isolate Alkalilimnicola sp. NM-DCM-1. PulD7 is 701 amino acids large with a carbohydrate binding module (CBM) 48 at the N-terminal. The full length PulD7 and N- and C-terminal truncated versions were cloned, heterologously expressed and functionally characterized. PulD7 displayed maximal activity at 55 °C, pH 9.5 and 2 M NaCl. PulD7 had good thermal stability, with a half-life of 693 min at 50 °C. PulD7 is an amylopullulanase, hydrolyzing both α‑1,4‑ and α‑1,6‑glycosidic bonds in soluble starch and pullulan, respectively...
January 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29342111/cytotoxicity-evaluation-of-turmeric-extract-incorporated-oil-in-water-nanoemulsion
#10
Hee Jeong Yoon, Xiaowei Zhang, Min Gyeong Kang, Gyeong Jin Kim, Sun Young Shin, Sang Hong Baek, Bom Nae Lee, Su Jung Hong, Jun Tae Kim, Kwonho Hong, Hojae Bae
To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8...
January 17, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29341916/effects-of-surfactant-based-permeation-enhancers-on-mannitol-permeability-histology-and-electrogenic-ion-transport-responses-in-excised-rat-colonic-mucosae
#11
Sam Maher, Joanne Heade, Fiona McCartney, Seona Waters, Sinéad B Bleiel, David J Brayden
Surfactant-based intestinal permeation enhancers (PEs) are constituents of several oral macromolecule formulations in clinical trials. This study examined the interaction of a test panel of surfactant-based PEs with isolated rat colonic mucosae mounted in Ussing chambers in an attempt to determine if increases in transepithelial permeability can be separated from induction of mucosal perturbation. The aim was to assess the effects of PEs on (i) apparent permeability coefficient (Papp) of [14C]-mannitol on (ii) histology score and (iii) short-circuit current (ΔIsc) responses to a cholinomimetic (carbachol, CCh)...
January 13, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29341900/lamotrigine-loaded-poly-%C3%A9-d-l-lactide-co-caprolactone-nanoparticles-as-brain-delivery-system
#12
Hussein O Ammar, Mahmoud M Ghorab, Azza A Mahmoud, Iman M Higazy
Management of epilepsy requires brain delivery therapy, therefore, this study was aimed to prepare lamotrigine loaded poly-ɛ-(d,l-lactide-co-caprolactone) (PLCL) nanoparticles using spontaneous emulsification solvent diffusion method. Nanoparticles for brain delivery required to have a particle size <200 nm, polydispesity index <0.2 and a sustained drug release properties. For such aim different factors were considered in preparing the nanoparticles as PLCL monomers' ratio, type of organic solvent used to prepare the nanoparticles, amount of PLCL and Pluronic®F127 in the nanoparticles...
January 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29340416/self-assembly-of-cationic-gemini-surfactants-alkanediyl-bis-dimethyldodecyl-ammonium-bromide-in-cyclohexane-effects-of-spacer-length-on-their-association-into-reverse-lyotropic-liquid-crystalline-or-reverse-vesicles
#13
Shenglu Deng, Jianxi Zhao
Herein, homogeneous solutions of cationic gemini surfactants, alkanediyl-α,ω-bis(dimethyldodecylammonium bromide), referred to as 12-s-12 where s = 2, 4, 6, 8, and 10, in cyclohexane have been prepared with the help of sodium hexanoate (SH) or sodium laurate (SL). These surfactants self-assembled in cyclohexane to form various aggregating structures, which were characterised by small-angle X-ray scattering (SAXS) together with polarised microscopy observations. The results showed that 12-2-12/SH, where the gemini had the shortest spacer among this series, formed an inverse micellar cubic liquid crystalline phase of the Fd3m structure...
January 17, 2018: Soft Matter
https://www.readbyqxmd.com/read/29339408/development-of-the-swimbladder-surfactant-system-and-biogenesis-of-lysosome-related-organelles-is-regulated-by-blos1-in-zebrafish
#14
Tianbing Chen, Guili Song, Huihui Yang, Lin Mao, Zongbin Cui, Kaiyao Huang
Hermansky-Pudlak syndrome (HPS) is a human autosomal recessive disorder that is characterized by oculocutaneous albinism and a deficiency of the platelet storage pool resulting from defective biogenesis of lysosome-related organelles (LROs). To date, ten HPS genes have been identified, three of which belong to the octamer complex BLOC-1 (biogenesis of lysosome-related organelles complex 1). One subunit of the BLOC-1 complex, BLOS1, also participates in the BLOC-1-related complex (BORC). Due to lethality at the early embryo stage in BLOS1 knockout mice, the function of BLOS1 in the above two complexes and whether it has a novel function are unclear...
January 16, 2018: Genetics
https://www.readbyqxmd.com/read/29338533/enhanced-solubility-oral-bioavailability-and-anti-osteoporotic-effects-of-raloxifene-hcl-in-ovariectomized-rats-by-igepal-co-890-nanomicelles
#15
Jaleh Varshosaz, Vahab Ziaei, Mohsen Minaiyan, Ali Jahanian, Leila Seyed Tabatabaei
The purpose of the present study was to enhance the bioavailability and anti-osteoporotic effects of raloxifene HCl (RH) by increasing its solubility and inhibition of the p-glycoprotein-pump using surfactant micelles of Igepal CO-890. The micelles were prepared by the direct method and their critical micellar concentration, drug dissolution rate, saturated solubility, drug loading and surface morphology were defined. The cytotoxicity of Igepal CO-890 and its ability to inhibit the p-glycoprotein pump were studied on Caco-2 cells...
January 16, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29338268/predicting-surface-tensions-of-surfactant-solutions-from-statistical-mechanics
#16
Han-Jae Jeremy Cho, Vishnu Sresht, Evelyn N Wang
The importance of surfactants to various industries necessitates a predictive understanding of their surface tension and adsorption behavior in terms of molecular characteristics. Previous models are highly empirical, require fitting parameters, and have limited applicability at various temperatures. Here, we provide a surface tension model based on statistical mechanics that (1) is thermodynamically consistent, (2) provides higher predictive power wherein surface tension can be calculated for any tail length, concentration, and temperature from molecular parameters, and (3) provides a physical understanding of the important molecular interactions at play...
January 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29338250/pickering-emulsion-formation-of-paraffin-wax-in-ethanol-water-mixture-stabilized-by-primary-polymer-particles-and-wax-microspheres-thereof
#17
Zuoxu Xiao, Hongyan Cao, Xubao Jiang, Xiang Zheng Kong
Stable dispersions of paraffin wax droplets and their nano- and microspheres have broad applications. Despite intensive efforts, the production of uniform wax spheres remains a challenge. For their preparation, abundant surfactants and other additives are commonly used to stabilize the dispersions. These additives are hardly removable and entrain often adverse consequence in many applications, particularly in biological and medical applications, where microspheres with absolutely clean surface are preferred...
January 16, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29338168/nanocapsules-of-magnetic-au-self-assembly-for-dna-migration-and-secondary-self-assembly
#18
Ling Wang, Yitong Wang, Shuli Dong, Yongming Deng, Jingcheng Hao
In order to endow valuable responsiveness to self-assemblies of Au nanoparticles, the magnetic Au nanoparticles (Au NPs)/CTACe mixtures were firstly prepared by using emulsion self-assembly of a magnetic surfactant, C16H33(CH3)3N+[CeCl3Br]-. A versatile of morphology of self-assemblies of Au NPs could be controlled by the counterions in surfactants including [CeCl3Br]-, [FeCl3Br]- and Br- as well as solvent. In particular, magnetic counterion, [CeCl3Br]-, can induce self-grown of Au NPs in emulsion self-assembly process due to the oxidability of [CeCl3Br]-...
January 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29337676/alkyl-polyglucoside-vs-ethoxylated-surfactant-based-microemulsions-as-vehicles-for-two-poorly-water-soluble-drugs-physicochemical-characterization-and-in-vivo-skin-performance
#19
Nataša Z Bubić Pajić, Marija N Todosijević, Gordana M Vuleta, Nebojša D Cekić, Vladimir D Dobričić, Sonja R Vučen, Bojan R Čalija, Milica Ž Lukić, Tanja M Ilić, Snežana D Savić
Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29337552/molecular-dynamics-simulations-of-the-oil-detachment-from-the-hydroxylated-silica-surface-effects-of-surfactants-electrostatic-interactions-and-water-flows-on-the-water-molecular-channel-formation
#20
Jian Tang, Zhou Qu, Jianhui Luo, Lanyan He, Pingmei Wang, Ping Zhang, Xianqiong Tang, Yong Pei, Bin Ding, Baoliang Peng, Yunqing Huang
The detachment process of an oil molecular layer or drop situated above a horizontal substrate was often described by a three-stage process. In this mechanism, the water molecule penetration and diffusion between the oil phase and the solid phase was proposed to be a crucial step to aid in removal of oil drops from solid surfaces. In this work, the detachment process of a two-dimensional alkane molecule layer from a silica surface in aqueous surfactant solutions is studied by means of molecular dynamics (MD) simulations...
January 16, 2018: Journal of Physical Chemistry. B
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