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Dyslipidemia in diabetes

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https://www.readbyqxmd.com/read/28329937/-correlation-between-self-reported-gingival-bleeding-and-type-2-diabetes-mellitus-in-aged-%C3%A2-18-years-adults-in-china
#1
Q Zhang, Z X Li, Y Yang, C X Wang, L M Wang, L H Wang
Objective: To understand the correlation between self-reported gingival bleeding and type 2 diabetes mellitus (T2DM) in adults in China. Methods: The database of China' s 2010 Chronic Disease and Risk Factor Surveillance (CCDRFS) survey among people aged ≥18 years was used to analyze the demographic characteristics of subjects with self-reporting gingival bleeding and the prevalence of major chronic diseases among adults. Correlation and interaction analyses were conducted on the relationships between frequent gingival bleeding and T2DM, hypertension and dyslipidemia, and interaction of age and gingival bleeding, age and hypertension, age and dyslipidemia, age and gender on the prevalence of T2DM...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28329340/baseline-characteristics-of-participants-in-the-aspree-aspirin-in-reducing-events-in-the-elderly-study
#2
John J McNeil, Robyn L Woods, Mark R Nelson, Anne M Murray, Christopher M Reid, Brenda Kirpach, Elsdon Storey, Raj C Shah, Rory S Wolfe, Andrew M Tonkin, Anne B Newman, Jeff D Williamson, Jessica E Lockery, Karen L Margolis, Michael E Ernst, Walter P Abhayaratna, Nigel Stocks, Sharyn M Fitzgerald, Ruth E Trevaks, Suzanne G Orchard, Lawrence J Beilin, Geoffrey A Donnan, Peter Gibbs, Colin I Johnston, Richard H Grimm
Background: There are no primary prevention trials of aspirin with relevant geriatric outcomes in elderly people. ASPirin in Reducing Events in the Elderly (ASPREE) is a placebo-controlled trial of low-dose aspirin that will determine whether 5 years of daily 100-mg enteric-coated aspirin extends disability-free and dementia-free life in a healthy elderly population and whether these benefits outweigh the risks. Methods: Set in primary care, this randomized double-blind placebo-controlled trial has a composite primary endpoint of death, incident dementia or persistent physical disability...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28321058/patient-perspectives-on-combination-therapy-of-a-once-weekly-oral-medication-plus-daily-medication-for-lifestyle-related-chronic-diseases
#3
Mitsuyoshi Takahara, Toshihiko Shiraiwa, Naoko Ogawa, Mayumi Yamamoto, Yuko Kusuda, Megumi Shindo, Saki Hashio, Naoto Katakami, Taka-Aki Matsuoka, Iichiro Shimomura
Objective The current study investigated whether or not patients taking multiple daily oral medications for lifestyle-related chronic diseases would have positive perspectives on changing one of their medications to a once-weekly one. Methods A total of 1,071 Japanese outpatients participated in the current study. We performed a questionnaire-based survey and compared the current satisfaction with the ongoing daily oral treatment (current daily-only treatment) and an expected satisfaction with an imaginary oral treatment changing one of their daily oral medications to a once-weekly oral medication (imaginary daily-and-weekly treatment)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28320161/circulating-autoantibodies-against-the-nr2-peptide-of-the-nmda-receptor-are-associated-with-subclinical-brain-damage-in-hypertensive-patients-with-other-pre-existing-conditions-for-vascular-risk
#4
S González-García, A González-Quevedo, Z Hernandez-Diaz, L Alvarez Camino, M Peña-Sanchez, A Cordero-Eiriz, M Brown, J A Gaya, M Betancourt-Losa, I Fernandez-Almirall, M C Menendez-Sainz, R Fernandez-Carriera
Arterial hypertension (HT) and other vascular pre-existing conditions (PEC) generate asymptomatic brain damage which increases the occurrence of stroke and cognitive decline. The aim of this work was to explore if serum antibodies against the NR2 subunit of the NMDA receptor (NR2Ab) could predict subclinical brain damage (SBD) in hypertensive patients with PEC. Forty seven neurologically asymptomatic hypertensive subjects were classified according to the number of PEC (retinopathy, overweight/obesity, diabetes mellitus and dyslipidemia)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28318686/probiotic-supplementation-for-management-of-cardiovascular-risk-factors-in-adults-with-type-ii-diabetes-a-systematic-review-and-meta-analysis
#5
Fatemeh Hendijani, Vajihe Akbari
BACKGROUND & AIMS: The effectiveness of probiotics in control of hypertension and dyslipidemia in diabetic patients remains unclear. Therefore, we systematically reviewed relevant data to elucidate the effects of probiotics on blood pressure and lipid profile of type 2 diabetic patients. METHODS: We searched PubMed, ISI Web of Knowledge, Scopus, The Cochrane Library, ClinicalTrials.gov, ProQuest Dissertations and Theses databases until May 2016. The primary outcomes were systolic blood pressure (SBP) and diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG)...
February 24, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28316372/dyslipidemia-rather-than-type-2-diabetes-mellitus-or-chronic-periodontitis-affects-the-systemic-expression-of-pro-and-anti-inflammatory-genes
#6
Rafael Nepomuceno, Bárbara Scoralick Villela, Sâmia Cruz Tfaile Corbi, Alliny De Souza Bastos, Raquel Alves Dos Santos, Catarina Satie Takahashi, Silvana Regina Perez Orrico, Raquel Mantuaneli Scarel-Caminaga
A high percentage of type 2 diabetes mellitus (T2D) patients are also affected by dyslipidemia and chronic periodontitis (CP), but no studies have determined the gene expression in patients that are simultaneously affected by all three diseases. We investigated the systemic expression of immune-related genes in T2D, dyslipidemia, and CP patients. One hundred and fifty patients were separated into five groups containing 30 individuals each: (G1) poorly controlled T2D with dyslipidemia and CP; (G2) well-controlled T2D with dyslipidemia and CP; (G3) normoglycemic individuals with dyslipidemia and CP; (G4) healthy individuals with CP; (G5) systemic and periodontally healthy individuals...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28315561/polymorphisms-of-lipid-metabolism-enzyme-coding-genes-in-patients-with-diabetic-dyslipidemia
#7
Aslı Tetik Vardarlı, Ece Harman, Vildan Bozok Çetintaş, Meral Kayıkçıoğlu, Egemen Vardarlı, Ayhan Zengi, Ali Şahin Küçükaslan, Zuhal Eroğlu
OBJECTIVE: The polymorphisms/mutations of genes encoding proteins and enzymes involved in lipoprotein metabolism play important roles in the development of diabetic dyslipidemia. The aim of our study was to investigate the effects of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662), and MNSOD (rs4880) gene polymorphisms on lipid metabolism and diabetic dyslipidemia. METHODS: This case-control study included 217 patients with diabetic dyslipidemia and 212 healthy age- and gender-matched individuals...
March 3, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28314924/leptin-induces-osteoblast-differentiation-of-human-valvular-interstitial-cells-via-the-akt-and-erk-pathways
#8
Mickael Rosa, Camille Paris, Yoann Sottejeau, Delphine Corseaux, Emmanuel Robin, Madjid Tagzirt, Francis Juthier, Ramadan Jashari, Antoine Rauch, André Vincentelli, Bart Staels, Eric Van Belle, Sophie Susen, Annabelle Dupont
AIMS: Calcific aortic valve disease (CAVD) affects 2-6% of the population over 65 years, and age, gender, smoking, overweight, dyslipidemia, diabetes contribute to the development of this disease. CAVD results, in part, from the osteoblast differentiation of human valvular interstitial cells (VICs). This study aims to elucidate the effects of leptin on osteoblast phenotype of VICs and the signalling pathways involved. METHODS: Patients who underwent aortic valve replacement for CAVD (n = 43) were included in this study...
March 18, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28306532/evaluation-of-the-sub-chronic-toxicity-profile-of-the-corm-of-xanthosoma-sagittifolium-on-hematology-and-biochemistry-of-alloxan-induced-diabetic-wistar-rats
#9
Olayinka A Oridupa, Oluyemisi F Folasire, Adedotun J Owolabi
Background Hematological and biochemical changes associated with diabetes mellitus and probable reversal were assessed in alloxan-induced diabetic Wistar rats fed with varied percentages of Xanthosoma sagittifolium corm feed (Xs). The changes were compared to normoglycemic rats and diabetic rats treated with glibenclamide. Methods The study had eight groups in all with group 8 (control) consisting of five normoglycemic rats fed with normal rat pellets (Nrp). Diabetes was experimentally induced by intraperitoneal injection of alloxan to normoglycemic rats...
March 11, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28300627/serum-uric-acid-is-associated-with-better-executive-function-in-men-but-not-in-women-baseline-assessment-of-the-elsa-brasil-study
#10
Cristina Pellegrino Baena, Claudia Kimie Suemoto, Sandhi Barreto, Paulo Lotufo, Isabela Benseñor
BACKGROUND: Serum uric acid (SUA) may protect against free radical stress damage and was previously linked to cognitive impairment in older adults, but evidence in middle-aged adults is scarce. PURPOSE: We sought to analyze whether SUA is associated with cognitive performance in apparently healthy middle-aged participants in the ELSA-Brasil cohort study. METHODS: We excluded participants older than age 65, those taking allopurinol, benzbromarone, or medications that could impair cognitive performance, those with previous stroke, and those with incomplete data on cognitive tests or SUA...
March 11, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28299459/the-impact-of-evacuation-on-the-incidence-of-chronic-kidney-disease-after-the-great-east-japan-earthquake-the-fukushima-health-management-survey
#11
Yoshimitsu Hayashi, Masato Nagai, Tetsuya Ohira, Hiroaki Satoh, Akira Sakai, Akira Ohtsuru, Mitsuaki Hosoya, Yukihiko Kawasaki, Hitoshi Suzuki, Atsushi Takahashi, Yoshihiro Sugiura, Hiroaki Shishido, Hideto Takahashi, Seiji Yasumura, Junichiro James Kazama, Shigeatsu Hashimoto, Gen Kobashi, Kotaro Ozasa, Masafumi Abe
BACKGROUND: About 146,000 people were forced into long-term evacuation due to the nuclear power plant accident caused by the Great East Japan Earthquake in 2011. Disaster is known to induce hypertension in survivors for a certain period, but it is unclear whether prolonged disaster stress influences chronic kidney disease (CKD). We conducted an observational cohort study to elucidate the effects of evacuation stress on CKD incidence. METHODS: Participants were individuals living in communities near the Fukushima nuclear power plant, aged 40-74 years without CKD as of their 2011 general health checkup (non-evacuees: n = 9780, evacuees: n = 4712)...
March 15, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28298836/transforming-growth-factor-%C3%AE-1-c509t-g800a-and-t869c-gene-polymorphisms-and-risk-of-ischemic-stroke-in-north-indian-population-a-hospital-based-case-control-study
#12
Pradeep Kumar, Shubham Misra, Amit Kumar, Mohammad Faruq, Sunil Shakya, Gyan Vardhan, Subiah Vivekanandhan, Achal Kumar Srivastava, Kameshwar Prasad
BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) is a multifunctional pleiotropic cytokine involved in inflammation and pathogenesis of cerebrovascular diseases. There is limited information on the association between variations within the TGF-β1 gene polymorphisms and risk of ischemic stroke (IS). The aim of this study was to investigate the association of the TGF-β1 gene (C509T, G800A, and T869C) polymorphisms, and their haplotypes with the risk of IS in North Indian population...
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28296786/association-between-macular-degeneration-and-mild-to-moderate-chronic-kidney-disease-a-nationwide-population-based-study
#13
Chun-Yu Chen, Ciou-Sia Dai, Chin-Chan Lee, Yu-Chiau Shyu, Ting-Shuo Huang, Ling Yeung, Chi-Chin Sun, Huang-Yu Yang, I-Wen Wu
Chronic kidney disease (CKD) and macular degeneration (MD) are 2 grave diseases leading to significant disability secondary to renal failure and blindness. The 2 diseases share not only common risk factors but also similar pathogenic mechanisms to renal and retinal injuries. Previous epidemiological studies indicated association between these 2 diseases. However, this concept is challenged by recent investigations. Patients with mild to moderate CKD (n = 30,696) between January 1, 1995 and December 31, 2005 were selected from the Taiwan National Health Insurance Database...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295387/short-and-long-term-clinical-predictors-of-pharmacological-cardioversion-of-persistent-atrial-fibrillation-by-dofetilide-a-retrospective-cohort-study-of-160-patients
#14
Hafeez Ul Hassan Virk, Waqas T Qureshi, Nayani Makkar, Joseph Bastawrose, Nektarios Souvaliotis, Joshua Aziz, Emad Aziz
INTRODUCTION: Dofetilide is a class III antiarrhythmic prescribed to cardiovert persistent atrial fibrillation (AF) to sinus rhythm (SR). HYPOTHESIS: To determine the clinical predictors of cardioversion and readmission in persistent AF patients on dofetilide. METHODS: We analyzed 160 patients with persistent AF who were started on dofetilide and followed for 1 year. We examined age, sex, race, hypertension, diabetes, smoking, dyslipidemia, CAD, left ventricular ejection fraction (LVEF), creatinine, BMI and concomitant use of calcium channel blockers (CCB), β-blockers in a multivariable logistic regression model...
March 14, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28293638/metabolic-disorders-in-hiv-infected-adolescents-receiving-protease-inhibitors
#15
Jeerunda Santiprabhob, Surapong Tanchaweng, Sirinoot Maturapat, Alan Maleesatharn, Watcharee Lermankul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Keswadee Lapphra, Wanatpreeya Phongsamart, Kulkanya Chokephaibulkit
Protease inhibitor (PI) may cause abnormal glucose metabolism, abnormal lipid metabolism, and metabolic syndrome in HIV-infected adults but less well studied in Asian adolescents. This cross-sectional study evaluated anthropometric factors, oral glucose tolerance test, and lipid profiles of perinatally HIV-infected Thai adolescents who had received PI-based antiretroviral therapy for at least 6 months. Eighty adolescents were enrolled [median (IQR) age 16.7 (14.6-18.0) years, 42 males]. Metabolic syndrome, prediabetes, and type 2 diabetes mellitus (T2DM) were found in 8 (10%), 17 (22...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28293152/risk-profile-of-coronary-heart-disease-among-the-staff-members-of-qassim-university-saudi-arabia
#16
Sultan A L Nohair, Abdulrahman A L Mohaimeed, Fawzy Sharaf, Zahid Naeem, Farid Midhet, Homaidan A L Homaidan, Sandra J Winter
OBJECTIVE: To estimate the risk profile of coronary heart disease (CHD) among the staff members of Qassim University and assess their knowledge in a screening campaign in Qassim region, Saudi Arabia. METHODS: A cross-sectional study was conducted among male and female staff at Qassim University campus. All employees of Qassim University were invited to participate in the study. Data were collected through a self-administered questionnaire. The study sample size was 233 staff and employees...
January 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28292348/development-and-validation-of-a-model-for-predicting-diabetic-nephropathy-in-chinese-people
#17
Li Chen, Ke Xin Sun, Juan Juan, Kai Fang, Kuo Liu, Xue Yin Wang
OBJECTIVE: To develop a risk model for predicting later development of diabetic nephropathy (DN) in Chinese people with type 2 diabetes mellitus (T2DM) and evaluate its performance with independent validation. METHODS: We used data collected from the project 'Comprehensive Research on the Prevention and Control of Diabetes', which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013. A total of 11,771 eligible participants were included in our study...
February 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28291054/progression-of-atherosclerosis-in-hiv-infected-individuals-prospective-data-from-an-asian-cohort
#18
Grace Lui, Ronald Cw Ma, Ping Chook, Chun-Kwok Wong, Claudia Ht Tam, Michael Hm Chan, Shui-Shan Lee, Rity Yk Wong, Catherine Sk Cheung, Kin-Wing Choi, Ping-Chung Leung, Ka-Hing Wong, Kenny Cw Chan, Nelson Lee
BACKGROUND: The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1) the rate of progression of atherosclerosis in HIV-infected individuals, and (2) metabolic and inflammatory parameters that may predict atherosclerosis progression in HIV-infected individuals in an Asian cohort. SETTING: A prospective, longitudinal study was performed among adults attending an HIV Metabolic clinic in Hong Kong...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28290857/-association-of-i-d-and-786-polymorphisms-of-ace-and-nos3-genes-with-features-of-the-course-of-ischemic-heart-disease-and-diabetes-mellitus-type-2
#19
S A Afanasiev, E F Muslimova, T Y Rebrov, T N Sergienko, A N Repin
AIM: to study relationship of ACE insertion-deletion (I/D) polymorphism and NOS3 T-786C polymorphism with characteristics of the course of ischemic heart disease (IHD) at the background of diabetes mellitus. MATERIALS AND METHODS: Were examined 114 patients with IHD, 29.8% of patients had type 2 diabetes mellitus. ACE and NOS3 polymorphisms were determined by allele-specific polymerase chain reaction with primers by "Lytech". RESULTS: Patients with combined pathology belonged to older age group, had increased frequency of obesity and predominance of functional class II chronic heart failure...
September 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290785/-genetic-risk-factors-of-macrovascular-complications-in-patients-with-type-2-diabetes
#20
A A Bystrova, A S Ulitina, M V Kim, S A Skoryukova, V V Miroshnikova, A A Panteleeva, N A Korelskaya, Zhu He Zhu He, M A Nikolaev, S N Pchelina, E I Baranova, E I Krasilnikova
High risk of macrovascular complications in patients with type 2 diabetes mellitus (T2DM) is caused by insulin resistance and atherogenic dyslipidemia that may be genetically determined. The aim of this study was to assess the association of polymorphic genetic variants APOA5 (S19W/rs3135506), CETP (Taq1B/rs708272), PON1 (Q192R /rs662) and PPARG (Pro12Ala /rs1801282) with T2DM and macrovascular complications in patients with T2DM resident in Northwestern Russia. We examined 386 patients with T2DM and 199 healthy controls...
February 2017: Kardiologiia
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