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https://www.readbyqxmd.com/read/28095909/prevalence-and-genetic-characterization-of-cryptosporidium-species-and-giardia-duodenalis-in-lambs-in-oromia-special-zone-central-ethiopia
#1
Teklu Wegayehu, Md Robiul Karim, Junqiang Li, Haileeyesus Adamu, Berhanu Erko, Longxian Zhang, Getachew Tilahun
BACKGROUND: Cryptosporidium and Giardia duodenalis are gastro-intestinal parasites that infect human and animals worldwide. Both parasites share a broad host range and are believed to be zoonosis. The aim of this study was to identify the species of Cryptosporidium and assemblages of G. duodenalis in lambs and to elucidate their role in zoonotic transmission. RESULTS: A total of 389 fecal samples were collected from lambs and screened by microscopy and nested PCR targeting the small-subunit ribosomal RNA for Cryptosporidium; and the small-subunit ribosomal RNA, triose phosphate isomerase, β-giardin, and glutamate dehydrogenase genes for G...
January 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28092617/supplementation-of-pigs-diet-with-zinc-and-copper-as-alternative-to-conventional-antimicrobials
#2
B Dębski
Modern commercial pig farming systems inflict increased stress in animals, which often leads to various negative changes in the gastro-intestinal tract, especially in the case of piglets. Ban of antibiotics, used as growth promoters, has caused a need for alternatives to conventional antimicrobials in swine diets. Use of pre-/or probiotics, organic acids and plant extracts is often recommended, but it seems that zinc oxide and cooper salts, which were traditionally included in high doses to piglets diet, possess the highest efficacy...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28081355/oral-delivery-of-probiotics-in-poultry-using-ph-sensitive-tablets
#3
Tao Jiang, Hui-Shan Li, Geon Goo Han, Bijay Singh, Sang-Kee Kang, Jin-Duck Bok, Dae-Duk Kim, Zhong-Shan Hong, Yun-Jaie Choi, Chong-Su Cho
As alternatives to antibiotics in live stocks, probiotics have been used although most of them in the form of liquid or semisolid formulations which show low cell viability after oral administration. Therefore, suitable dry dosage forms should be developed for live stocks to protect probiotics against the low pH in the stomach such that the products have higher probiotics survivability. Here, in order to develop a dry dosage forms of probiotics for poultry, we used hydroxyproyl methylcellulose phthalate 55 (HPMCP 55) as a tablet forming matrix to develop probiotics in a tablet form for poultry...
January 12, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28077642/studies-on-the-interaction-of-tumor-derived-hd5-alpha-defensins-with-adenoviruses-and-implications-for-oncolytic-adenovirus-therapy
#4
Charles Vragniau, Jens-Martin Hübner, Peter Beidler, Sucheol Gil, Kamola Saydaminova, Zhuo-Zhuang Lu, Roma Yumul, Hongjie Wang, Maximilian Richter, Pavel Sova, Charles Drescher, Pascal Fender, André Lieber
: Defensins are small anti-microbial peptides capable of neutralizing human adenovirus (HAdV) in vitro by binding capsid proteins and blocking endosomal escape of virus. In humans, the alpha defensin HD5 is produced by specialized epithelial cells of the gastro-intestinal and genito-urinary tracts. Here we demonstrate that HD5 is also expressed as an active, secreted peptide by epithelial ovarian and lung cancer cells in situ, in patient biopsies. This finding triggered us to study the role of HD5 in infection and spread of replication-competent, oncolytic HAdV type 3 virus...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28072691/the-effectiveness-and-safety-of-dual-antiplatelet-therapy-in-ischemic-cerebrovascular-disease-with-intracranial-and-extracranial-arteriostenosis-in-chinese-patients-a-randomized-and-controlled-trail
#5
Feng-Tong Zuo, Hui Liu, Hui-Jun Wu, Na Su, Jie-Qiong Liu, Ai-Qin Dong
BACKGROUND: There are limited data on the effect of dual antiplatelet treatment with clopidogrel plus aspirin in patients with ischemic cerebrovascular disease and intracranial and extracranial arteriostenosis. The aim of our study was to evaluate the efficacy and safety of aspirin plus clopidogrel in the treatment of ischemic cerebrovascular disease with intracranial and extracranial arteriostenosis. METHODS: Patients with clinically evident acute cerebral infarction or transient ischemic attack combined with intracranial and extracranial arteriostenosis (greater than 50%) who were unsuitable or reluctance to perform stent implantation were enrolled in this study...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070848/intravaginal-delivery-of-polyphenon-60-and-curcumin-nanoemulsion-gel
#6
Atinderpal Kaur, Yashaswee Saxena, Rakhi Bansal, Sonal Gupta, Amit Tyagi, Rakesh Kumar Sharma, Javed Ali, Amulya Kumar Panda, Reema Gabrani, Shweta Dang
Polyphenon 60 (P60) and curcumin (CUR) were loaded in a single nanoemulsion system and their combined antibacterial action was studied against uropathogenic Escherichia coli. To enhance availability at target organs and to inhibit enzymatic degradation in gastro intestinal tract, vaginal route of administration was explored. P60 + CUR nanoemulsion (NE) was formulated by ultra-sonication and optimized using Box-Behnken design. Optimized NE showed Z-average of 211.2 nm, polydispersity index of 0.343, and zeta potential of -32...
January 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28064052/development-of-novel-carboxymethyl-cellulose-k-carrageenan-blends-as-an-enteric-delivery-vehicle-for-probiotic-bacteria
#7
Alireza Dafe, Hossein Etemadi, Habib Zarredar, Gholam Reza Mahdavinia
This study reports a novel carrier based on blends of carboxymethyl cellulose (CMC) and k-Carrageenan (k-Carr) for probiotic colon delivery. Lactobacillus plantarum ATCC:13643 (L. plantarum) cells were encapsulated in CMC/k-Carr blends by extrusion method. k-carrageenan was used as a coating agent to improve encapsulation of L. plantarum cells in carboxymethyl cellulose biopolymer. K-Carrageenan and carboxymethyl cellulose were ionically cross-linked with K(+) and Ca(2+) ions, respectively. Optical and scanning electron microscopy obviously showed the random distribution of L...
January 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28062288/designation-of-pathogenic-resistant-bacteria-in-the-sparusaurata-sea-collected-in-tunisia-coastlines-correlation-with-high-performance-liquid-chromatography-tandem-mass-spectrometry-analysis-of-antibiotics
#8
Amina Zouiten, Ines Mehri, Asma Beltifa, Asma Ghorbel, Olivier Sire, Joris Van Loco, Hassen Abdenaceur, Tim Reyns, Hedi Ben Mansour
Vibrio is characterized by a large number of species and some of them are human pathogens causing gastro intestinal and wound infections through the ingestion or manipulation of contaminated fishes including Vibrio parahaemolyticus and Vibrio alginolyticus. In this study, we reported the phenotypic and molecular characterization of Vibrio parahaemolyticus and Vibrio alginolyticus strains isolated from wild and farm sea bream (Sparus aurata L.) along the Tunisian coast from December 2015 to April 2016. Therefore, the antibiograms indicate a difference between farmed and wild fish...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28056966/pseudorabies-virus-infection-aujeszky-s-disease-in-an-iberian-lynx-lynx-pardinus-in-spain-a-case-report
#9
A Javier Masot, María Gil, David Risco, Olga M Jiménez, José I Núñez, Eloy Redondo
BACKGROUND: The only natural hosts of Pseudorabies virus (PRV) are members of the family Suidae (Sus scrofa scrofa). In species other than suids infection is normally fatal. In these mammals, including carnivores, PRV typically causes serious neurologic disease. The endangered Iberian lynx (Lynx pardinus) is a wild feline endemic to south-western Europe (Iberian Peninsula). The Iberian lynx was found to be the world's most endangered felid species in 2002. In wild felines, PRV infection has only been previously reported once in a Florida panther in 1994...
January 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28056795/bleeding-outcomes-associated-with-rivaroxaban-and-dabigatran-in-patients-treated-for-atrial-fibrillation-a-systematic-review-and-meta-analysis
#10
Pravesh Kumar Bundhun, Mohammad Zafooruddin Sani Soogund, Abhishek Rishikesh Teeluck, Manish Pursun, Akash Bhurtu, Wei-Qiang Huang
BACKGROUND: Warfarin is commonly used as a secondary prevention of stroke in patients with atrial fibrillation (AF). However, limitations have been observed even with the use of this medication. Recently, several newer direct oral anticoagulants (DOACs) have been approved for use by the food and drug administrations. Unfortunately, these newer drugs have seldom been compared directly with each other. Therefore, this study aimed to compare the bleeding events associated with rivaroxaban and dabigatran in patients treated for non-valvular AF...
January 6, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28047012/we-fg-207b-01-best-in-physics-imaging-abdominal-ct-with-three-k-edge-contrast-materials-using-a-whole-body-photon-counting-scanner-initial-results-of-a-large-animal-experiment
#11
M Lakshmanan, R Symons, T Cork, C Davies-Venn, K Rice, A Malayeri, V Sandfort, D Bluemke, A Pourmorteza
PURPOSE: To demonstrate the feasibility of in vivo three-material decomposition techniques using photon-counting CT (PCCT) with possible advantage of resolving arterial and venous flow of an organ simultaneously. METHODS: Abdominal PCCT scans were acquired using a prototype whole-body PCCT with four energy thresholds (25/50/75/90keV) in a canine. Bismuth subsalicylate (60 mg) was administered orally one day prior to scanning. Immediately prior to CT scan, gadoteric acid (60 ml, Dotarem, Guerbet) was intravenously injected, followed in ten minutes by a 20mL injection of iodinated contrast (iopamidol 370 mg/mL, Bracco)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044954/haemobilia-a-rare-cause-of-upper-gastro-intestinal-bleeding
#12
Daniel Ion, Carmen Iuliana Mavrodin, Mihai Bogdan Șerban, Tudor Marinescu, Dan Nicolae Păduraru
Haemobilia is a rare cause of upper gastrointestinal bleeding that consists of haemorrhage within the biliary tree. Most cases of haemobilia are due to iatrogenic cause, laparoscopic or open cholecystectomy, abdominal trauma, gallstones, hepatic tumours, vascular aneurism. We present the case of a male patient admitted in the surgery department for epigastric and right hypochondria pain, nausea and vomiting. Open cholecystectomy was performed with a trans-cystic tube drainage. Postoperative outcome was favourable but with a continuous decrease in haemoglobin level...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28044950/clinico-pathological-profile-and-surgical-outcome-of-patients-of-gastrointestinal-tuberculosis-undergoing-laparotomy
#13
Priyank Pathak, Shantanu Kumar Sahu, Saurabh Agrawal
: Tuberculosis is one of the earliest diseases affecting the mankind. Abdominal tuberculosis constitutes a common public health issue in developing countries like ours. Gastrointestinal tuberculosis often involves the ileocecal region. Surgery in case of abdominal tuberculosis is required to overcome the deleterious effects of the disease like tissue disorganization, obstruction and perforatio. AIMS AND OBJECTIVES: 1. To study the various clinical profiles of gastrointestinal tuberculosis in patients undergoing laparotomy; 2...
November 2016: Chirurgia
https://www.readbyqxmd.com/read/28029082/probiotics-in-curing-allergic-and-inflammatory-conditions-research-progress-and-futuristic-vision
#14
Kuldeep Dhama, Shyma K Latheef, Ashok Kumar Munjal, Rekha Khandia, Hari Abdul Samad, Hafiz M N Iqbal, Sunil K Joshi
BACKGROUND: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Probiotics can inhibit the systemic invasion of pathogens entering through the GI mucosa/ oral cavity and have been found to possess effective prophylactic and therapeutic utilities against various infectious pathogens as well as non-infectious diseases and disorders...
December 26, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28029080/synthesis-and-study-of-analgesic-and-anti-inflammatory-activities-of-amide-derivatives-of-ibuprofen
#15
Abbas Ahmadi, Mohsen Khalili, Zahra Olama, Shirin Karami, Babak Nahri-Niknafs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs worldwide and represent a mainstay in the therapy of acute and chronic pain and inflammation. The traditional NSAIDs like ibuprofen (I) contain free carboxylic acid group which can produce gastro-intestinal (GI) damage in long-term using of them. In order to obtain the novel NSAIDs with less side effects; carboxylic acid moiety has been modified into various amide groups which is the most active area of research in this family...
December 26, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28027806/-actinomycotic-brain-abscess-in-immunocompetent-patient
#16
Mikel Armendariz-Guezala, José Undabeitia-Huertas, Nicolás Samprón-Lebed, Marta Michan-Mendez, Irune Ruiz-Diaz, Enrique Úrculo-Bareño
BACKGROUND: The actinomyces is germ commonly found in the normal flora of the oral cavity and gastro-intestinal and uro-genital tracts. Involvement in other locations is a very uncommon event. OBJECTIVES: To describe a patient with an actinomicotyc brain abscess CLINICAL CASE: We report the case of a patient who suffered a seizure and decreased level of consciousness. Imaging tests revealed the presence of lesions both in the lung and in the brain. An urgent craniotomy was performed and the diagnosis of actinomicotyc abscess was obtained...
December 24, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28024457/haemorrhagic-enteritis-of-turkeys-current-knowledge
#17
Kuldeep Dhama, Vasudevan Gowthaman, Kumaragurubaran Karthik, Ruchi Tiwari, Swati Sachan, M Asok Kumar, M Palanivelu, Yashpal Singh Malik, Raj Kumar Singh, Muhammad Munir
Haemorrhagic enteritis virus (HEV), an adenovirus associated with acute hemorrhagic gastro-intestinal disease of 6-11 weeks old turkeys predominantly hampers both humoral and cellular immunity. Affected birds are more prone to secondary complications (like colibacillosis and clostridiosis) and failure to mount an effective vaccine-induced immune response. HEV belongs to the new genus Siadenovirus. Feco-oral transmission is the main route of entry of the virus and it mainly colonizes bursa, intestine and spleen...
December 27, 2016: Veterinary Quarterly
https://www.readbyqxmd.com/read/28018095/gastrointestinal-neuromuscular-apparatus-an-underestimated-target-of-gut-microbiota
#18
EDITORIAL
Michele Pier Luca Guarino, Michele Cicala, Lorenza Putignani, Carola Severi
Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastro-intestinal diseases has been largely investigated. Growing evidence suggest that microbiota can influence gastro-intestinal motility. The current working hypothesis is that dysbiosis-driven mucosal alterations induce the production of several inflammatory/immune mediators which affect gut neuro-muscular functions. Besides these indirect mucosal-mediated effects, the present review highlights that recent evidence suggests that microbiota can directly affect enteric nerves and smooth muscle cells functions through its metabolic products or bacterial molecular components translocated from the intestinal lumen...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28007005/analgesic-effect-of-topical-oral-capsaicin-gel-in-burning-mouth-syndrome
#19
Mette Rose Jørgensen, Anne Marie Lynge Pedersen
OBJECTIVE: To investigate the effectiveness of repeated topical application of oral capsaicin gel in two different concentrations for relief of burning/stinging sensations in patients with burning mouth syndrome (BMS). MATERIAL AND METHODS: This randomized double-blind cross-over study included 22 female patients with BMS. The patients were randomized for topical application of either 0.01% or 0.025% oral capsaicin gel on the dorsal part of tongue three times daily for 14 days, followed by 14 days wash-out period, and finally treatment with the other concentration of oral gel three times daily for 14 days...
March 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28000563/metabolomics-as-a-functional-tool-in-screening-gastro-intestinal-diseases-where-are-we-in-high-throughput-screening
#20
Rohit Gundamaraju, Ravichandra Vemuri, Rajaraman Eri, Hamilton M Ishiki, Ericsson Coy-Barrera, Nagendra Sastry Yarla, Sócrates Golzio Dos Santos, Mateus Feitosa Alves, José Maria Barbosa Filho, Margareth F F M Diniz, Marcus T Scotti, Luciana Scotti
Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants, and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ advanced tools like GC-MS, 1HNMR and GC-MS/SPME which reveal valuable information concerning disease severity and differentiation...
December 20, 2016: Combinatorial Chemistry & High Throughput Screening
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