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https://www.readbyqxmd.com/read/29341931/bioinspired-capsules-based-on-nanocellulose-xyloglucan-and-pectin-the-influence-of-capsule-wall-composition-on-permeability-properties
#1
T Paulraj, A V Riazanova, A J Svagan
Materials based on renewable biopolymers, selective permeability and stimuli-responsive release/loading properties play an important role in biomedical applications. Here, in order to mimic the plant primary cell-wall, microcapsules have been fabricated using cell wall polysaccharides, namely pectin, xyloglucan and cellulose nanofibers. For the first time, a large amount of xyloglucan was successfully included in such capsules. These capsules demonstrated stimuli-responsive (ON/OFF) permeability and biocompatibility...
January 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29335453/engineering-yarrowia-lipolytica-to-simultaneously-produce-lipase-and-single-cell-protein-from-agro-industrial-wastes-for-feed
#2
Jinyong Yan, Bingnan Han, Xiaohua Gui, Guilong Wang, Li Xu, Yunjun Yan, Catherine Madzak, Dujie Pan, Yaofeng Wang, Genhan Zha, Liangcheng Jiao
Lipases are scarcely exploited as feed enzymes in hydrolysis of lipids for increasing energy supply and improving nutrient use efficiency. In this work, we performed homologous overexpression, in vitro characterization and in vivo assessment of a lipase from the yeast Yarrowia lipolytica for feed purpose. Simultaneously, a large amount of yeast cell biomass was produced, for use as single cell protein, a potential protein-rich feed resource. Three kinds of low cost agro-industrial wastes were tested as substrates for simultaneous production of lipase and single cell protein (SCP) as feed additives: sugarcane molasses, waste cooking oil and crude glycerol from biodiesel production...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335029/estimating-the-proportion-of-clinically-diagnosed-infectious-and-non-infectious-animal-diseases-in-ganta-afeshum-woreda-eastern-tigray-zone-ethiopia
#3
Mebrahtu Tedla, Mebrahtu Gebreselassie
OBJECTIVE: This study was performed with the objective of identifying the proportion of emerging and endemic livestock diseases using cross sectional survey. RESULT: A total of 285 clinically diseased animals were presented to a veterinary clinic and diagnosed tentatively based on history, clinical sign, and simple laboratory diagnostics and from the study, actinomycosis (15.83%), mastitis (15%), tick infestation (10%), respiratory diseases (9.16%) and gastro intestinal parasitism (9...
January 15, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29329324/variability-and-cost-implications-of-three-generations-of-the-roche-lightcycler%C3%A2-480
#4
Maria Dullaert-de Boer, Onno W Akkerman, Marloes Vermeer, Dorine L J Hess, Huib A M Kerstjens, Richard M Anthony, Tjip S van der Werf, Dick van Soolingen, Adri G M van der Zanden
Real time PCR has become a dominant method for the highly sensitive detection of pathogens in clinical material. Real time PCR can generate a fluorescence signal by using fluorescence labelled probes, allowing us to detect and semi quantify the amount of amplified DNA. Here we test the variability of the detection system and cost implications of three different versions of the LightCycler® 480 (LC480), focusing on the intensity of fluorescence and Cq in monoplex and multiplex rtPCRs. For gastro-intestinal pathogens there was no correlation between the intensity of fluorescence and the Cq value in the different LC480 types...
2018: PloS One
https://www.readbyqxmd.com/read/29316246/sleep-quality-and-functional-gastrointestinal-disorders-a-psychological-issue
#5
Michel Bouchoucha, Florence Mary, Cyriaque Bon, Bakhtiar Bejou, Gheorghe Airinei, Robert Benamouzig
BACKGROUND / AIMS: Sleep disorders are often associated with functional gastro-intestinal disorders (FGIDs). This study aims to evaluate the association of sleep disorders with specific FGIDs and to assess the related importance of psychological disorders. METHODS: We included 1009 consecutive FGID patients (71% female), aged 48.2 ± 16.7 years (M±SD), BMI 26.9 ± 11.2 kg/m2 . These patients filled in a Rome III questionnaire and underwent a psychological evaluation on anxiety and depression...
January 8, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29314176/improved-diagnostic-stratification-of-digitised-barrett-s-oesophagus-biopsies-by-tp53-immunohistochemical-staining
#6
M J van der Wel, L C Duits, R E Pouw, C A Seldenrijk, G J A Offerhaus, M Visser, F J Ten Kate, K Biermann, L A A Brosens, M Doukas, C Huysentruyt, A Karrenbeld, G Kats-Ugurlu, J S van der Laan, G van Lijnschoten, F C P Moll, A H A G Ooms, H van der Valk, J G Tijssen, J J Bergman, S L Meijer
AIMS: Interobserver agreement for dysplasia in Barrett's oesophagus (BO) is low and guidelines advise expert review of dysplastic cases. We assessed the added value of p53 immunohistochemistry (IHC) on the homogeneity within a group of dedicated gastro-intestinal (GI) pathologists. METHODS AND RESULTS: Sixty single hematoxylin & eosin (HE) slide referral BO cases (20 low-grade dysplasia (LGD); 20 high-grade dysplasia (HGD) and 20 non-dysplastic BO (NDBO) reference cases) were digitalised and independently assessed twice in a random order by 10 dedicated GI pathologists...
January 3, 2018: Histopathology
https://www.readbyqxmd.com/read/29308530/the-incidence-mutational-status-risk-classification-and-referral-pattern-of-gastro-intestinal-stromal-tumours-in-the-netherlands-a-nationwide-pathology-registry-palga-study
#7
Arie J Verschoor, J V M G Bovée, L I H Overbeek, P C W Hogendoorn, H Gelderblom
Symptomatic gastrointestinal stromal tumours (GIST) are infrequent with an incidence of 12.7 per million inhabitants in the western population. We studied whether the incidence of GIST has further increased between 2003 and 2012 and assessed the frequency of mutations, risk groups, histological subtypes and immunohistochemistry results. From PALGA, the nationwide Dutch Pathology Registry, pathology excerpts from all patients with a GIST or GIST-like tumour between 2003 and 2012 were retrieved to calculate incidence rates...
January 8, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29302827/colonic-perforation-due-to-severe-cytomegalovirus-disease-in-granulomatosis-with-polyangiitis-after-immunosuppression
#8
REVIEW
Alessandra Soriano, Nazareno Smerieri, Stefano Bonilauri, Loredana De Marco, Alberto Cavazza, Carlo Salvarani
Granulomatosis with polyangiitis (GPA) is a small-vessel necrotizing granulomatous vasculitis typically involving upper airways, lungs, and kidneys, which may lead to end-organ damage and life-threatening complications. Major infections during GPA course represent a considerable concern in the management of the disease. Cytomegalovirus (CMV) infection and disease are rare but significant complications in the course of GPA being associated with high morbidity and mortality rates. Colonic perforation due to CMV colitis is exceedingly rare and has so far almost exclusively been documented in HIV, renal transplant, and systemic lupus erythematosus patients...
January 4, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29301732/gastrointestinal-lymphomas-french-intergroup-clinical-practice-recommendations-for-diagnosis-treatment-and-follow-up-snfge-ffcd-gercor-unicancer-sfcd-sfed-sfro-sfh
#9
REVIEW
Tamara Matysiak-Budnik, Bettina Fabiani, Christophe Hennequin, Catherine Thieblemont, Georgia Malamut, Guillaume Cadiot, Olivier Bouché, Agnès Ruskoné-Fourmestraux
INTRODUCTION: This document is a summary of the French Intergroup guidelines on the management of gastro-intestinal lymphomas, available on the web-site of the French Society of Gastroenterology, SNFGE (www.tncd.org), updated in September 2017. METHODS: This collaborative work was realised under the auspices of several French medical societies and involved clinicians with specific expertise in the field of gastrointestinal lymphomas, including gastroenterologists, haematologists, pathologists, and radiation oncologist, representing the major French or European clinical trial groups...
December 18, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29299370/safety-of-selective-internal-radiation-therapy-sirt-with-yttrium-90-microspheres-combined-with-systemic-anticancer-agents-expert-consensus
#10
REVIEW
Andrew Kennedy, Daniel B Brown, Jonas Feilchenfeldt, John Marshall, Harpreet Wasan, Marwan Fakih, Peter Gibbs, Alexander Knuth, Bruno Sangro, Michael C Soulen, Gianfranco Pittari, Ricky A Sharma
Selective internal radiation therapy (SIRT) with microspheres labelled with the β-emitter yttrium-90 (Y-90) enables targeted delivery of radiation to hepatic tumors. SIRT is primarily used to treat inoperable primary or metastatic liver tumors. Eligible patients have usually been exposed to a variety of systemic anticancer therapies, including cytotoxic agents, targeted biologics, immunotherapy and peptide receptor radionuclide therapy (PRRT). All these treatments have potential interactions with SIRT; however, robust evidence on the safety of these potential combinations is lacking...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29295650/amifostine-reduces-gastro-intestinal-toxicity-after-autologous-transplantation-for-multiple-myeloma
#11
Ehsan Malek, Vinita Gupta, Richard Creger, Paolo Caimi, Anant Vatsayan, Fahrettin Covut, Qaiser Bashir, Richard Champlin, Ruby Delgado, Gabriela Rondon, Brenda Cooper, Marcos de Lima, Hillard M Lazarus, Muzaffar Qazilbash
High-dose melphalan (HDM) followed by autologous hematopoietic cell transplantation (auto-HCT) remains the standard-of-care therapy for multiple myeloma (MM) even with the availability of proteasome inhibitors and immunomodulatory drugs. Gastrointestinal (GI) toxicity is the main cause of morbidity after HDM. Amifostine, a cytoprotective agent, may reduce HDM-associated GI toxicity. We conducted a case control study comparing HDM + auto-HCT with or without amifostine for MM patients. One hundred and seven patients treated at University Hospitals Cleveland Medical Center who received pre-transplant amifostine were compared to 114 patients treated at MD Anderson Cancer Center without use of this agent...
January 2, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29288805/the-ability-of-two-in-vitro-lipolysis-models-reflecting-the-human-and-rat-gastro-intestinal-conditions-to-predict-the-in-vivo-performance-of-snedds-dosing-regimens
#12
Scheyla D V S Siqueira, Malak Al Sawaf, Kirsten Gräeser, Huiling Mu, Anette Müllertz, Thomas Rades
In this work, the influence of drug load and physical state of R3040 in self-nanoemulsifying drug delivery systems (SNEDDS) on R3040 absorption in rats was assessed. Furthermore, an in vitro lipolysis model simulating rat conditions (rat lipolysis model) was compared to a human lipolysis model in regard to the prediction of the in vivo data. The formulations were SNEDDS 80 %, containing R3040 at 80 % of its equilibrium solubility in SNEDDS (Seq); super-SNEDDS solution with R3040 supersaturated at 200 % Seq; super-SNEDDS suspension containing R3040 at 200 % Seq; Chasing principle (drug-free SNEDDS followed by R3040 aqueous suspension) and R3040 aqueous suspension...
December 27, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29288116/a-study-on-outcome-of-binding-pancreaticogastrostomy-following-pancreaticoduodenectomy-a-prospective-study
#13
Dronacharya Routh, Nishant Pathak, C S Naidu, A K Singh, P P Rao, Priya Ranjan
INTRODUCTION: The type of anastomosis of the pancreas following pancreaticoduodenectomy is often attributed to the reason for pancreatic leak. Results of various randomized trials comparing pancreaticojejunostomy and pancreaticogastrostomy are conflicting one suggesting advantage over the other and vice versa. In this study we intend to critically analyze a novel technique of binding pancreaticogastrostomy following pancreaticoduodenectomy. AIMS AND OBJECTIVES: The aim of this study is to see the outcome of binding pancreaticogastrostomy by evaluating the technical aspects of binding PG and study the incidence of post-operative complications...
December 26, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29287924/the-effect-of-a-concomitant-renal-injury-on-the-outcome-of-colonic-trauma
#14
G V Oosthuizen, R Weale, V Y Kong, J L Bruce, R J Urry, G L Laing, D L Clarke
BACKGROUND: The management of colon injuries has steadily evolved over the course of the last half century. So too has the management of renal trauma. It is not clear from the literature as to whether concomitant colon and renal injuries carry increased risk of morbidity and mortality, and whether this combination of injuries necessitates a specifically tailored management approach. METHODS: A retrospective review was carried out for the period January 2012 to December 2016...
December 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29287395/bioaccessibility-of-four-calcium-sources-in-different-whey-based-dairy-matrices-assessed-by-in-vitro-digestion
#15
Lucie Lorieau, Linda Le Roux, Frédéric Gaucheron, Amandine Ligneul, Etienne Hazart, Didier Dupont, Juliane Floury
Numerous calcium sources are available to enrich food, but their behavior during digestion is still unknown. This study focused on the influence of the gastro-intestinal pH, the food structure and the calcium source on the bioaccessibility of the nutrient. Four calcium sources were studied: calcium carbonate, calcium citrate malate, calcium phosphate and calcium bisglycinate. These were added to dairy matrices, containing cream and whey proteins, of different forms (liquid or gel). The kinetics of solubility and ionic calcium concentration during in vitro digestion were studied, as function of gastro-intestinal pH...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287383/change-of-phenolics-carotenoids-and-antioxidant-capacity-following-simulated-gastrointestinal-digestion-and-dialysis-of-selected-edible-green-leaves
#16
K D P P Gunathilake, K K D S Ranaweera, H P V Rupasinghe
The bio-accessibility of phenolics, flavonoids, rutin, β-carotene and lutein and changes in antioxidant activities in six edible greens during simulating gastro-intestinal conditions has been investigated. It was found that the amount of dialysable phenolics, flavonoids and carotenoids which potentially available for further uptake is varying depending on the leafy type. Bioavailable phenolics after the gastric-phase, intestinal-phase and in dialysable fraction were in the ranges of 13.9-71.8%, 14.4-77.4% and 3...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29284546/medical-emergencies-related-to-ethanol-and-illicit-drugs-at-an-annual-nocturnal-indoor-electronic-dance-music-event
#17
Paul Calle, Nora Sundahl, Kristof Maudens, Sarah Mr Wille, Diederik Van Sassenbroeck, Koen De Graeve, Stefan Gogaert, Peter De Paepe, Dieter Devriese, Geert Arno, Peter Blanckaert
Introduction Medical problems are frequently encountered during electronic dance music (EDM) events. Problem There are uncertainties about the frequencies and severity of intoxications with different types of recreational drugs: ethanol, "classical" illicit party drugs, and new psychoactive substances (NPS). METHODS: Statistical data on the medical problems encountered during two editions of an indoor electronic dance event with around 30,000 attendants were retrieved from the Belgian Red Cross (Mechelen, Belgium) database...
December 29, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29281873/safety-results-and-analysis-of-eribulin-efficacy-according-to-previous-microtubules-inhibitors-sensitivity-in-the-french-prospective-expanded-access-program-for-heavily-pre-treated-metastatic-breast-cancer
#18
Renaud Sabatier, Véronique Diéras, Xavier Pivot, Etienne Brain, Henri Roché, Jean-Marc Extra, Audrey Monneur, Magali Provansal, Carole Tarpin, François Bertucci, Patrice Viens, Christophe Zemmour, Anthony Gonçalves
Purpose: Eribulin is approved for advanced breast cancers refractory to anthracyclines and taxanes. Efficacy according to sensitivity to previous therapies has been poorly explored. Materials and Methods: Safety data were collected prospectively and we retrospectively collected efficacy data from the five French centres that participated in the Eribulin E7389-G000-398 expanded access program. Our main objectives were exploration of safety and analysis of eribulin efficacy (progression-free survival [PFS] and overall survival [OS]) according to sensitivity to the last microtubule-inhibiting agent administered...
December 28, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29277903/impact-of-food-processing-and-simulated-gastro-intestinal-digestion-on-gliadin-immunoreactivity-in-rolls
#19
Bartosz Brzozowski
BACKGROUND: Enzymatic modification of wheat proteins during dough fermentation, and its digestion supported by peptidases of microbiological origin can cause degradation of important peptides in the pathogenesis of coeliac disease. However, baking bread and the high temperature associated with could change a physicochemical and immunological properties of proteins. Thermal changes in spatial structure of proteins and its hydrolysis can lead to masking or degrading immunoreactive peptides...
December 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29277809/long-term-outcomes-of-carbon-ion-radiotherapy-for-locally-advanced-squamous-cell-carcinoma-of-the-uterine-cervix
#20
Noriyuki Okonogi, Masaru Wakatsuki, Shingo Kato, Shintaro Shiba, Daijiro Kobayashi, Hiroki Kiyohara, Kumiko Karasawa, Tatsuya Ohno, Takashi Nakano, Tadashi Kamada, Makio Shozu
BACKGROUND/AIM: To evaluate the long-term outcomes of carbon-ion radiotherapy (C-ion RT) for locally advanced cervical squamous cell carcinoma (LAC-SqCC) in 2 prospective phase I/II studies. PATIENTS AND METHODS: In the first study, 14 patients were treated with 68.8-72.8 Gy (RBE)/24 fractions. In a subsequent study, 22 patients were treated with 64.0-72.0 Gy (RBE)/20 fractions while limiting the dose to the gastro-intestinal (GI) <60 Gy (RBE). RESULTS: The 10-year local control rates were 92% and 61% for the patients administered a total dose of 72...
January 2018: Anticancer Research
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