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risky play

Ying Luo, Sihong You, Jirong Wang, Shuling Fan, Jie Shi, Ai Peng, Tingting Yu
Purpose: Sumoylation plays a critical role in gene regulation and tumorigenesis, and is hypothesized to correlate with the development of various cancers. So far, there has been no reported association between sumoylation-related genes and the risk of gastric cancer (GC). Methods: A total of 17 tagging single-nucleotide polymorphisms (tag-SNPs) in 5 sumoylation-related genes were selected and genotyped by SNaPshot in a case-control study, including 1021 GC patients and 1304 controls. Odds ratio (OR) and 95% confidential interval (CI) were computed to evaluate the genetic association of the onset of GC...
2017: Journal of Cancer
Benjamin J Smith, Feng Xue, Vita Droutman, Emily Barkley-Levenson, A James Melrose, Lynn C Miller, John R Monterosso, Antoine Bechara, Paul Robert Appleby, John L Christensen, Carlos G Godoy, Stephen J Read
HIV is most prevalent among men who have sex with men (MSM), and although most MSM use condoms consistently during casual sex, some take risks. To better understand the psychology of those risky decisions, we examined neural correlates of playing a virtual sexual "hook up" game in an fMRI scanner in MSM who had, in the past 90 days, been sexually risky (N = 76) or safe (N = 31). We found that during potentially risky sexual choices, previously risky MSM had more right insula activity than previously safe MSM...
November 15, 2017: Social Cognitive and Affective Neuroscience
Elizabeth A Walshe, Chelsea Ward McIntosh, Daniel Romer, Flaura K Winston
Motor vehicle crashes remain a leading cause of injury and death in adolescents, with teen drivers three times more likely to be in a fatal crash when compared to adults. One potential contributing risk factor is the ongoing development of executive functioning with maturation of the frontal lobe through adolescence and into early adulthood. Atypical development resulting in poor or impaired executive functioning (as in Attention-Deficit/Hyperactivity Disorder) has been associated with risky driving and crash outcomes...
October 28, 2017: International Journal of Environmental Research and Public Health
Cristina Nava, Verónica C Neves, Malvina Andris, Marie-Pierre Dubois, Philippe Jarne, Mark Bolton, Joël Bried
Bottleneck episodes may occur in small and isolated animal populations, which may result in decreased genetic diversity and increased inbreeding, but also in mating strategy adjustment. This was evaluated in the vulnerable and socially monogamous Monteiro's Storm-petrel Hydrobates monteiroi, a seabird endemic to the Azores archipelago which has suffered a dramatic population decline since the XVth century. To do this, we conducted a genetic study (18 microsatellite markers) in the population from Praia islet, which has been monitored over 16 years...
November 15, 2017: Die Naturwissenschaften
Latoya S Moss
There is an increasing call to attend to the needs of students in distress (Reynolds, 2013). Furthermore, research has begun to highlight links between distress, risky, or dangerous behaviors as well as issues in mental health in the higher education population (Deasy, Coughlan, Pironom, Jourdan, & Mannix-McNamara, 2014). The National Alliance on Mental Health and the Jed Foundation (National Alliance on Mental Illness & the Jed Foundation, 2016) estimate that about 20% of enrolled college students will face some type of mental illness...
November 2017: Psychological Services
Ivan Tomić, Jakov Burić, Aleksandar Štulhofer
The use of sexually explicit material (SEM) has become a part of adolescent sexual socialization, at least in the Western world. Adolescent and young people's SEM use has been associated with risky sexual behaviors, which has recently resulted in policy debates about restricting access to SEM. Such development seems to suggest a crisis of the preventive role of parental oversight. Based on the Differential Susceptibility to Media Effects Model, this study assessed the role of parental monitoring in the context of adolescent vulnerability to SEM-associated risky or potentially adverse outcomes (sexual activity, sexual aggressiveness, and sexting)...
October 25, 2017: Archives of Sexual Behavior
Gaurav Dave, Tiarney Ritchwood, Tiffany L Young, Malika Roman Isler, Adina Black, Aletha Y Akers, Ziya Gizlice, Connie Blumenthal, Leslie Atley, Mysha Wynn, Doris Stith, Crystal Cene, Danny Ellis, Giselle Corbie-Smith
PURPOSE: Parents and caregivers play an important role in sexual socialization of youth, often serving as the primary source of information about sex. For African American rural youth who experience disparate rates of HIV/sexually transmitted infection, improving caregiver-youth communication about sexual topics may help to reduce risky behaviors. This study assessed the impact of an intervention to improve sexual topic communication. DESIGN: A Preintervention-postintervention, quasi-experimental, controlled, and community-based trial...
November 2017: American Journal of Health Promotion: AJHP
Bronwen Lichtenstein, Cynthia Rodgers, Lauren Eb Marefka, Marla D Hinson, Dayna Cook-Heard, Stephen D Rygiel, Marsha S Sturdevant
HIV-positive adolescents are required by law to notify sexual partners, but can find it difficult to achieve this goal. This article offers practice guidance for counselling HIV-positive adolescents about sexual disclosure in clinical settings and for building confidence in managing sexual lives with HIV. We use two vignettes to illustrate key differences between perinatally and sexually infected adolescents in terms of readiness to disclose, and include a set of strategies for both groups that can be tailored to individual circumstances and contexts...
January 2017: Journal of Infection Prevention
João F Guassi Moreira, Eva H Telzer
Numerous studies have established that the social context greatly affects adolescent risk taking. However, it remains unexplored whether adolescents' decision-making behaviors change when they take risks that affect other individuals such as a parent. In the current study, we sought to investigate how the social context influences risky decisions when adolescents' behavior affects their family using a formalized risk-taking model. Sixty-three early adolescents (Mage = 13.3 years; 51% female) played a risk-taking task twice, once during which they could make risky choices that only affected themselves and another during which their risky choices only affected their parent...
October 4, 2017: Developmental Science
Manuela Meraner, Robert Finger
The extent to which people are willing to take on risk, i.e. their risk preferences as well as subjective risk perception plays a major role in explaining their behavior. This is of particular relevance in agricultural production, which is inherently risky. The data presented here was collected amongst a total of 64 German farmers in 2015. It includes results of three different risk preference elicitation methods (multiple price list, business statements in four relevant domains and general self-assessment) as well as risk perception...
December 2017: Data in Brief
Le-Zong Chen, Cai-Yun He, Xuan Su, Jun-Ling Peng, Dong-Liang Chen, Zulu Ye, Dong-Dong Yang, Zi-Xian Wang, Feng Wang, Jian-Yong Shao, Rui-Hua Xu
The matricellular glycoprotein products of the SPP1 and SPARC genes play critical roles in many aggressive tumor phenotypes including gastric cancer. We sought to test whether the polymorphisms of these two genes, individually or jointly, influence gastric cancer susceptibility. Nine potentially functional, tagging single nucleotide polymorphisms (tagSNPs) of SPP1 and SPARC were selected and detected using the Kompetitive Allele Specific PCR method in 301 gastric cancer cases and 1441 healthy control subjects...
January 15, 2018: Gene
Sarah H Alfaraj, Jaffar A Al-Tawfiq, Talal A Altuwaijri, Marzouqa Alanazi, Nojoom Alzahrani, Ziad A Memish
BACKGROUND: Many outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) have occurred in health care settings and involved health care workers (HCWs). We describe the occurrence of an outbreak among HCWs and attempt to characterize at-risk exposures to improve future infection control interventions. METHODS: This study included an index case and all HCW contacts. All contacts were screened for MERS-CoV using polymerase chain reaction. RESULTS: During the study period in 2015, the index case was a 30-year-old Filipino nurse who had a history of unprotected exposure to a MERS-CoV-positive case on May 15, 2015, and had multiple negative tests for MERS-CoV...
September 25, 2017: American Journal of Infection Control
Guangfa Xiao, Xitao Wang, Yaqun Yu
BACKGROUND/AIMS: Pancreatic cancer cells (PCC) is one of the most risky cancers and gemcitabine (GEM) is the standard first-line drug for treating PCC. The PCC will develop drug resistance to GEM after a period of treatment. However, the detailed molecular mechanism of pathogenesis and drug resistance remains unresolved. METHODS: we employed qRT-PCR and western blot to examine the expression level of CXCR4, let-7a and HMGA2. In addition, we used MTT assay to detect cell proliferation and transwell assay to measure migration and invasiveness...
2017: Cellular Physiology and Biochemistry
Daniela Šincek, Jasmina Tomašić Humer, Ivana Duvnjak
BACKGROUND: This paper explores problematic Internet gaming in the context of other forms of risky behaviour. The basic premise is that children and adolescents at risk will display different types of risky behaviour in various settings. SUBJECTS AND METHODS: Children and adolescents (N=1150) were surveyed about (cyber)violence, problematic gaming (habits, motives and symptoms), self-disclosure via Facebook and self-esteem. RESULTS: Regular gamers were more violent both face-to-face and via the Internet, and were more prone to problematic gaming than occasional gamers...
September 2017: Psychiatria Danubina
Dorota Samojłowicz, Aleksandra Borowska-Solonynko, Marcin Kruczyk
A number of world literature reports indicate that a latent Toxoplasma gondii infection leads to development of central nervous system disorders, which in turn may lead to altered behavior in the affected individuals. T. gondii infection has been observed to play the greatest role in drivers, suicides, and psychiatric patients. Studies conducted for this manuscript involve a different, never before really reported correlation between latent T. gondii infection and ethanol abuse. A total of 538 decedents with a known cause of death were included in the study...
September 18, 2017: Forensic Science International
Justin C Strickland, Joshua S Beckmann, Craig R Rush, William W Stoops
BACKGROUND: Numerous studies in behavioral economics have demonstrated that individuals are more sensitive to the prospect of a loss than a gain (i.e., loss aversion). Although loss aversion has been well described in "healthy" populations, little research exists in individuals with substance use disorders. This gap is notable considering the prominent role that choice and decision-making play in drug use. The purpose of this pilot study was to evaluate loss aversion in active cocaine users...
November 1, 2017: Drug and Alcohol Dependence
Takele Menna Adilo, Hirut Megerssa Wordofa
BACKGROUND: The magnitude of unprotected sex to satisfy the desire for fertility among people living with HIV/AIDS (PLHIV) may rise more due to the availability of antiretroviral therapy (ART) in most HIV-affected countries. This could, however, have the risk of passing on HIV to sexual partners and children. The aim of this study, therefore, was to determine the magnitude and factors associated with the fertility desire of reproductive-age PLHIV in Addis Ababa, Ethiopia, for research-based and timely actions...
2017: HIV/AIDS: Research and Palliative Care
Hanna Savioja, Mika Helminen, Sari Fröjd, Mauri Marttunen, Riittakerttu Kaltiala-Heino
PURPOSE: To elucidate a possible connection between delinquency and adolescent sexual behaviours in different age groups from 14 to 20 and the role of depression therein. MATERIALS AND METHODS: Data were gathered from the cross-sectional Finnish School Health Promotion Study 2010 and 2011 with 186,632 respondents. We first examined the bivariate relationship between delinquency and sexual behaviour, and then proceeded to multivariate models accounting for self-reported depression...
September 13, 2017: European Journal of Contraception & Reproductive Health Care
Niamk K Shortt, Sarah J Rhynas, Aisha Holloway
It has been suggested that place, and interaction with the environment, may play a role in recovery from alcohol dependence. In this paper we report findings from a project that used an adapted photovoice methodology to better understand individuals' experience and perceptions of the role of place in recovery from alcohol dependence. Individuals attending a recovery café in central Scotland documented their environment and, in focus group settings, the individuals discussed and analysed their photographs. Here we report aspects of the environment, both therapeutic and risky, experienced by individuals negotiating the journey of dependence recovery...
September 2017: Health & Place
Kazuhiro Watanabe, Norito Kawakami, Kotaro Imamura, Akiomi Inoue, Akihito Shimazu, Toru Yoshikawa, Hisanori Hiro, Yumi Asai, Yuko Odagiri, Etsuko Yoshikawa, Akizumi Tsutsumi
The effects of Pokémon GO, a new mobile game application which utilizes augmented reality, on risky behavior and health have already been discussed in anecdotal evidence. However, there have been no studies about its effects on mental health. This study investigated the relationships between Pokémon GO and psychological distress from an existing workers' cohort in Japan. Online surveys were conducted to 3,915 full-time workers, at baseline (Nov 26, 2015-Feb 18, 2016) and at follow-up (Dec 1-4, 2016), using a self-report questionnaire...
September 7, 2017: Scientific Reports
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