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https://www.readbyqxmd.com/read/29155051/peripheral-monocyte-entry-is-required-for-alpha-synuclein-induced-inflammation-and-neurodegeneration-in-a-model-of-parkinson-disease
#1
Ashley S Harms, Aaron D Thome, Zhaoqi Yan, Aubrey M Schonhoff, Gregory P Williams, Xinru Li, Yudong Liu, Hongwei Qin, Etty N Benveniste, David G Standaert
Accumulation of alpha-synuclein (α-syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and subsequent neurodegeneration. Here, we used heterozygous reporter knock-in mice in which the first exons of the fractalkine receptor (CX3CR1) and of the C-C chemokine receptor type 2 (CCR2) are replaced with fluorescent reporters to study the role of resident microglia (CX3CR1+) and infiltrating peripheral monocytes (CCR2+), respectively, in the CNS...
November 16, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29154245/an-association-of-the-mcp-1-and-ccr2-single-nucleotide-polymorphisms-with-colorectal-cancer-prevalence
#2
Anna Walczak, Karolina Przybyłowska-Sygut, Andrzej Sygut, Adrianna Cieślak, Michał Mik, Łukasz Dziki, Adam Dziki, Ireneusz Majsterek
THE AIM OF THE STUDY: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. MATERIAL AND METHODS: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism...
October 31, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29150241/targeting-interleukin-1%C3%AE-protects-from-aortic-aneurysms-induced-by-disrupted-transforming-growth-factor-%C3%AE-signaling
#3
Francesco Da Ros, Raimondo Carnevale, Giuseppe Cifelli, Dario Bizzotto, Manuel Casaburo, Marialuisa Perrotta, Lorenzo Carnevale, Iolanda Vinciguerra, Stefania Fardella, Roberta Iacobucci, Giorgio M Bressan, Paola Braghetta, Giuseppe Lembo, Daniela Carnevale
Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets. Genetic studies have highlighted controversial roles of transforming growth factor β (TGF-β) signaling in aneurysm development. Here, we report on aneurysms developing in adult mice after smooth muscle cell (SMC)-specific inactivation of Smad4, an intracellular transducer of TGF-β. The results revealed that Smad4 inhibition activated interleukin-1β (IL-1β) in SMCs...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29145242/the-association-of-genetic-variants-in-chemokine-genes-with-the-risk-of-psoriasis-vulgaris-in-chinese-population-a-case-control-study
#4
Jin Zhang, Qiuhe Song, Kun Zhu, Jun Lu, Xiaogang Xiong, Fei Hao
This study aimed to investigate the influence of polymorphisms in chemokine genes, including MCP1, CCR2, and CCR5 with psoriasis vulgaris (PV) risk in a Chinese population.The genotyping of studied polymorphisms through polymerase chain reaction (PCR) and sequencing was conducted in 142 PV patients and 147 healthy controls. The genotype distribution of the polymorphisms in the control group was checked to determine whether it conformed to Hardy-Weinberg equilibrium (HWE). The genotype and allele frequencies were compared between PV patients and the healthy controls using Chi-square test...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142497/expression-of-ccl2-and-its-receptor-in-activation-and-migration-of-microglia-and-monocytes-induced-by-photoreceptor-apoptosis
#5
ChaoYi Feng, Xin Wang, TianJin Liu, Meng Zhang, GeZhi Xu, YingQin Ni
Purpose: To explore the effect of the CCL2 and CCR2 system on the activation and migration of microglia and monocytes in light-induced photoreceptor apoptosis. Methods: At 1 day, 3 days, 7 days, and 14 days after light exposure, OX42 and ED1 immunostaining were used to label the activation and migration of microglia and monocytes. Double immunostaining of CCL2 with terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL), OX42, or glial fibrillary acidic protein (GFAP) was applied to explore the relationships among CCL2, apoptotic photoreceptors, activated microglia and monocytes, and macroglial cells (Müller cells and astrocytes)...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29133591/chemokine-signaling-facilitates-early-stage-breast-cancer-survival-and-invasion-through-fibroblast-dependent-mechanisms
#6
Gage Brummer, Diana S Acevedo, Qingting Hu, Mike Portsche, Wei Fang, Min Yao, Brandon Zinda, Megan Myers, Nehemiah S Alvarez, Patrick Fields, Yan Hong, Fariba Behbod, Nikki Cheng
Ductal carcinoma in situ (DCIS) is the most common form of breast cancer, with 50,000 cases diagnosed every year in the United States. Over-treatment and under-treatment remain significant clinical challenges in patient care. Identifying key mechanisms associated with DCIS progression could uncover new biomarkers to better predict patient prognosis and improve guided treatment. Chemokines are small soluble molecules that regulate cellular homing through molecular gradients. CCL2-mediated recruitment of CCR2+ macrophages are a well-established mechanism for metastatic progression...
November 13, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29128509/monocyte-activation-is-elevated-in-women-with-knee-osteoarthritis-and-associated-with-inflammation-bmi-and-pain
#7
D Loukov, S Karampatos, M R Maly, D M E Bowdish
OBJECTIVE: Monocytes contribute to synovitis and disease pathogenesis in osteoarthritis (OA). Low-grade inflammation occurs in OA and correlates with disease severity and progression. Since monocyte development and function is altered by systemic inflammation, we analyzed monocyte numbers and function between individuals with knee OA and healthy age- and sex-matched controls. DESIGN: We analyzed markers of soluble and cellular inflammation in peripheral blood of women with knee OA and compared them to healthy age- and sex-matched controls...
November 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29123530/human-cardiac-derived-stem-progenitor-cells-fine-tune-monocyte-derived-descendants-activities-toward-cardiac-repair
#8
Noémie Dam, Hocine Rachid Hocine, Itziar Palacios, Olga DelaRosa, Ramón Menta, Dominique Charron, Armand Bensussan, Hicham El Costa, Nabila Jabrane-Ferrat, Wilfried Dalemans, Eleuterio Lombardo, Reem Al-Daccak
Cardiac repair following MI relies on a finely regulated immune response involving sequential recruitment of monocytes to the injured tissue. Monocyte-derived cells are also critical for tissue homeostasis and healing process. Our previous findings demonstrated the interaction of T and natural killer cells with allogeneic human cardiac-derived stem/progenitor cells (hCPC) and suggested their beneficial effect in the context of cardiac repair. Therefore, we investigated here whether monocytes and their descendants could be also modulated by allogeneic hCPC toward a repair/anti-inflammatory phenotype...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29116124/monocytes-from-patients-with-primary-ciliary-dyskinesia-show-enhanced-inflammatory-properties-and-produce-higher-levels-of-pro-inflammatory-cytokines
#9
M Cockx, M Gouwy, P Ruytinx, I Lodewijckx, A Van Hout, S Knoops, N Pörtner, I Ronsse, L Vanbrabant, V Godding, K De Boeck, J Van Damme, M Boon, S Struyf
Patients with Primary Ciliary Dyskinesia (PCD) suffer from recurrent upper and lower airway infections due to defects in the cilia present on the respiratory epithelium. Since chronic inflammatory conditions can cause changes in innate immune responses, we investigated whether monocytes isolated from the peripheral blood of pediatric PCD patients respond differently to inflammatory stimuli, compared to monocytes from healthy children and adults. The receptor for C5a (C5aR) was upregulated in PCD, whereas expression levels of the leukocyte chemoattractant receptors CCR1, CCR2, CCR5, BLT1 and FPR1 on PCD monocytes were similar to those on monocytes from healthy individuals...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115520/ccl2-ccr2-axis-induces-hepatocellular-carcinoma-invasion-and-epithelial-mesenchymal-transition-in%C3%A2-vitro-through-activation-of-the-hedgehog-pathway
#10
Huijie Zhuang, Gang Cao, Changhua Kou, Tao Liu
Chemokine (C-C motif) ligand 2 (CCL2) has been shown to play an important role in the regulation of tumor cell growth, metastasis and host immune response. CCL2 preferentially binds to the C-C chemokine receptor type 2 (CCR2), which is expressed in various tissues. However, the role of the CCL2/CCR2 axis in hepatocellular carcinoma (HCC) invasion and its molecular mechanisms remain unclear. The aim of this study was to elucidate this issue. The human HCC cell line MHCC-97H was treated with CCL2. Cyclopamine, a smoothened (SMO) antagonist, was used to inhibit SMO activity...
November 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29107385/ccl2-conditionally-determines-ccl22-dependent-th2-accumulation-during-tgf-%C3%AE-induced-breast-cancer-progression
#11
Palash Kumar Mandal, Subir Biswas, Gunjan Mandal, Suman Purohit, Arnab Gupta, Amita Majumdar Giri, Sougata Roy Chowdhury, Arindam Bhattacharyya
We investigated expressions of -CC chemokine ligand 2 (CCL2) and CCL5 in tumor samples from 147 breast cancer (BCa) patients and correlated with transforming growth factor-β (TGF-β) expression. We observed an inverse correlation of TGF-β expression with CCL2, CCL5 expression in early stages of BCa. On contrary, in late stages, CCL2, not CCL5, expression was found to be directly proportional with TGF-β expression. TGF-β stimulated MDA-MB-231 cells to express CCL2, however, downregulated both CCL2 and CCL5 in MCF-7...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29106985/the-chemokine-receptor-ccr2-maintains-plasmacytoid-dendritic-cell-homeostasis
#12
Oriane Cédile, Line Østerby Jørgensen, Ida Frank, Agnieszka Wlodarczyk, Trevor Owens
Thymic dendritic cells (DC) play a role in central tolerance. Three thymic DC subtypes have been described: plasmacytoid DC (pDC) and two conventional DC (cDC), CD8α(+) Sirpα(-) DC and Sirpα(+) CD8α(-) cDC. Both pDC and Sirpα(+) cDC can take up antigen in periphery and migrate into the thymus in response to chemokine signaling via CCR9 and CCR2 respectively. CCL2 is a major ligand for CCR2 and we previously showed that it was constitutively expressed in thymus, and that mice overexpressing CCL2 in thymus had reduced numbers of autoreactive T cells but elevated numbers of pDC...
October 26, 2017: Immunology Letters
https://www.readbyqxmd.com/read/29089636/ly6c-hi-inflammatory-monocytes-promote-susceptibility-to-leishmania-donovani-infection
#13
Cesar Terrazas, Sanjay Varikuti, Steve Oghumu, Heidi M Steinkamp, Nurittin Ardic, Jennifer Kimble, Hira Nakhasi, Abhay R Satoskar
Ly6C(hi) inflammatory monocytes (iMO) are critical for host defense against toxoplasmosis and malaria but their role in leishmaniasis is unclear. In this study, we report a detrimental role of Ly6C(hi) iMOs in visceral leishmaniasis (VL) caused by Leishmania donovani. We demonstrate that Ly6C(hi) iMOs are continuously recruited into the spleen and liver during L. donovani infection and they are preferential targets for the parasite. Using microarray-based gene expression profiling, we show that Ly6C(hi) iMOs isolated from the infected liver and spleen have distinct phenotypic and activation profiles...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29073102/human-papillomavirus-oncoproteins-induce-a-reorganization-of-epithelial-associated-%C3%AE-%C3%AE-t-cells-promoting-tumor-formation
#14
Dorien Van Hede, Barbara Polese, Chantal Humblet, Anneke Wilharm, Virginie Renoux, Estelle Dortu, Laurence de Leval, Philippe Delvenne, Christophe J Desmet, Fabrice Bureau, David Vermijlen, Nathalie Jacobs
It has been shown that γδ T cells protect against the formation of squamous cell carcinoma (SCC) in several models. However, the role of γδ T cells in human papillomavirus (HPV)-associated uterine cervical SCC, the third-leading cause of death by cancer in women, is unknown. Here, we investigated the impact of γδ T cells in a transgenic mouse model of carcinogenesis induced by HPV16 oncoproteins. Surprisingly, γδ T cells promoted the development of HPV16 oncoprotein-induced lesions. HPV16 oncoproteins induced a decrease in epidermal Skint1 expression and the associated antitumor Vγ5(+) γδ T cells, which were replaced by γδ T-cell subsets (mainly Vγ6(+) γδ(low)CCR2(+)CCR6(-)) actively producing IL-17A...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29066542/mechanisms-of-cns-viral-seeding-by-hiv-cd14-cd16-monocytes-establishment-and-reseeding-of-viral-reservoirs-contributing-to-hiv-associated-neurocognitive-disorders
#15
Mike Veenstra, Rosiris León-Rivera, Ming Li, Lucio Gama, Janice E Clements, Joan W Berman
HIV reservoirs persist despite antiretroviral therapy (ART) and are established within a few days after infection. Infected myeloid cells in the central nervous system (CNS) may contribute to the establishment of a CNS viral reservoir. The mature CD14(+) CD16(+) monocyte subset enters the CNS in response to chemokines, including CCL2. Entry of infected CD14(+) CD16(+) monocytes may lead to infection of other CNS cells, including macrophages or microglia and astrocytes, and to release of neurotoxic early viral proteins and additional cytokines...
October 24, 2017: MBio
https://www.readbyqxmd.com/read/29057937/significance-of-ccl2-ccl5-and-ccr2-polymorphisms-for-adverse-prognosis-of-japanese-encephalitis-from-an-endemic-population-of-india
#16
Purvita Chowdhury, Siraj Ahmed Khan
Japanese encephalitis (JE) is a major contributor for viral encephalitis in Asia. Vaccination programme has limited success for largely populated JE endemic countries like India and disease exposure is unavoidable. Involvement of chemokines and its co-receptors for adverse prognosis of JE have been documented both in vitro and in vivo. Identification of the genetic predisposing factor for JE infection in humans is crucial but not yet established. Therefore, we investigated the association of single nucleotide polymorphisms (SNPs) in chemokines (CCL2 and CCL5) and its co-receptors (CCR2 and CCR5) with their protein level for JE...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057516/porphyromonas-gingivalis-lipopolysaccharide-induces-over-production-of-cc-chemokine-ligand-2-via-toll-like-receptor-4-in-oral-lichen-planus
#17
Qi Zeng, Xi Yang, Xiaobing Chen, Juan Xia, Bin Cheng, Xiaoan Tao
BACKGROUND: We recently reported that the CC chemokine ligand 2 (CCL2)-CC receptor 2 (CCR2) axis was involved in the pathogenesis of oral lichen planus (OLP). However, the exact mechanism for the high expression of CCL2 in OLP specimens is not clear. Therefore, this study was designed to investigate the potential role of the toll-like receptor 4 (TLR-4) pathway in overproduction of CCL2 in OLP lesions. METHODS: Immunohistochemical staining and real-time RT-PCR were used to detect TLR-4, CCL2, and CCR2 expression in OLP lesions...
October 23, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29056937/cd14-cells-with-the-phenotype-of-infiltrated-monocytes-consist-of-distinct-populations-characterized-by-anti-inflammatory-as-well-as-pro-inflammatory-activity-in-gouty-arthritis
#18
Ji Hye Jeong, Seokchan Hong, Oh Chan Kwon, Byeongzu Ghang, Inseok Hwang, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
It has been suggested that inflammasome-mediated IL-1β production in monocytic cells is responsible for the acute inflammatory response in gouty arthritis. However, phenotypical and functional analyses of monocytes during gouty arthritis have yet to be conducted. Therefore, we investigated the characteristics of monocytes/macrophages in the synovial fluid cells of patients with acute gout. The number and frequency of monocytes/macrophages in the synovial fluid mononuclear cells (SFMCs) of patients was examined...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29052263/angiotensin-ii-c-c-chemokine-receptor2-5-axis-dependent-monocyte-macrophage-recruitment-contributes-to-progression-of-experimental-autoimmune-myocarditis
#19
Hongxiang Lu, Gangjun Zong, Shanshan Zhou, Yuanyuan Jiang, Rong Chen, Zhaoliang Su, Yan Wu
Angiotensin II (ANG II) plays critical roles in modulation of circulatory homeostasis and activation of innate and adaptive immunity and has also been implicated in several mouse models of autoimmune disease. However, how ANG II regulates macrophages and is involved in development of experimental autoimmune myocarditis (EAM) remains unclear. Therefore, the present study aimed to address the above question and explore possible mechanisms. EAM was induced in BALB/c mice. ANG II was quantitated by ELISA and hematoxylin and eosin staining was employed to analyze pathological changes and macrophage infiltration...
October 20, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29044327/generation-of-a-triple-fluorescent-mouse-strain-allows-a-dynamic-and-spatial-visualization-of-different-liver-phagocytes-in-vivo
#20
Brenda N Nakagaki, Maria A Freitas-Lopes, Érika Carvalho, Raquel Carvalho-Gontijo, Hortência M Castro-Oliveira, Rafael M Rezende, Denise C Cara, Mônica M Santos, Rodrigo Pestana Lopes, Bruna A David, Gustavo B Menezes
Resident and circulating immune cells have been extensively studied due to their almost ubiquitous role in cell biology. Despite their classification under the "immune cell department", it is becoming increasingly clear that these cells are involved in many different non-immune related phenomena, including fetus development, vascular formation, memory, social behavior and many other phenotypes. There is a huge potential in combining high-throughput assays - including flow cytometry and gene analysis - with in vivo imaging...
October 16, 2017: Anais da Academia Brasileira de Ciências
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