Yujia Susanna Qiao, Adam J Santanasto, Paul M Coen, Peggy M Cawthon, Steven R Cummings, Daniel E Forman, Bret H Goodpaster, Jaroslaw Harezlak, Marquis Hawkins, Stephen B Kritchevsky, Barbara J Nicklas, Frederico G S Toledo, Pamela E Toto, Anne B Newman, Nancy W Glynn
Performance fatigability is typically experienced as insufficient energy to complete daily physical tasks, particularly with advancing age, often progressing toward dependency. Thus, understanding the etiology of performance fatigability, especially cellular-level biological mechanisms, may help to delay the onset of mobility disability. We hypothesized that skeletal muscle energetics may be important contributors to performance fatigability. Participants in the Study of Muscle, Mobility and Aging completed a usual-paced 400-m walk wearing a wrist-worn ActiGraph GT9X to derive the Pittsburgh Performance Fatigability Index (PPFI, higher scores = more severe fatigability) that quantifies percent decline in individual cadence-versus-time trajectory from their maximal cadence...
October 16, 2023: Aging Cell