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Accelerometry and parkinson's disease

Annette Pantall, Silvia Del Din, Lynn Rochester
BACKGROUND: Postural instability is a common motor feature in people with Parkinson's disease (PD) together with non-motor features such as cognitive dysfunction. Management of postural instability is challenging as it is often resistant to dopaminergic therapy. Greater knowledge of postural control is essential to understand postural instability in PD. RESEARCH QUESTION: This study aimed to answer how postural control differs in people with PD compared to healthy older adults (HOA)...
April 13, 2018: Gait & Posture
Dongni Johansson, Anders Ericsson, Anders Johansson, Alexander Medvedev, Dag Nyholm, Fredrik Ohlsson, Marina Senek, Jack Spira, Ilias Thomas, Jerker Westin, Filip Bergquist
AIM: This 4-week open-label observational study describes the effect of introducing a microtablet dose dispenser and adjusting doses based on objective free-living motor symptom monitoring in individuals with Parkinson's disease (PD). METHODS: Twenty-eight outpatients with PD on stable levodopa treatment with dose intervals of ≤4 hour had their daytime doses of levodopa replaced with levodopa/carbidopa microtablets, 5/1.25 mg (LC-5) delivered from a dose dispenser device with programmable reminders...
May 2018: CNS Neuroscience & Therapeutics
Parisa Farzanehfar, Holly Woodrow, Michelle Braybrook, Sarah McGregor, Andrew Evans, Frank Nicklason, Malcolm Horne
It is common in medicine to titrate therapy according to target ranges of objectively measured parameters. Objective measurement of motor function is available for Parkinson's Disease (PD), making it possible to optimise therapy and clinical outcomes. In this study, an accelerometry based measurement and predefined target ranges were used to assess motor function in a Northern Tasmania PD cohort managed by a Movement Disorder clinic. Approximately 40% ( n  = 103) of the total PD population participated in this study and motor scores were within target in 22%...
2018: NPJ Parkinson's Disease
Sarah McGregor, Philip Churchward, Katarzyna Soja, Denise O'Driscoll, Michelle Braybrook, Hamid Khodakarami, Andrew Evans, Parisa Farzanehfar, Garun Hamilton, Malcolm Horne
Sleep disturbances are common in Parkinson's disease (PD). We used the Parkinson's KinetiGraph (PKG), an objective movement recording system for PD to assess night time sleep in 155 people aged over 60 and without PD (controls), 72 people with PD (PwP) and 46 subjects undergoing a Polysomnogram (PSG: 36 with sleep disorder and 10 with normal sleep). The PKG system uses a wrist worn logger to capture acceleration and derive a bradykinesia score (BKS) every 2 min over 6 days. The BKS ranges from 0-160 with higher scores associated with lesser mobility...
2018: NPJ Parkinson's Disease
Peter Jombík, Pavel Spodniak, Vladimír Bahýľ, Ján Necpál
The clinical differentiation of the tremor in Parkinson's disease (PD) and essential tremor (ET) can sometimes be challenging, especially in the early stage of the disease. As different neural oscillators are involved in the generation of these two types of tremor, their trajectorial analysis could also be different. The goal of this study was to investigate whether some disease-specific patterns related to their tremor trajectories in fact exist. The three-axial accelerometer signals of the hand tremor obtained from a total of 369 participants [49 with PD, 25 with isolated resting tremor (iRT), 133 with ET, and finally 162 normal subjects with physiological tremor (Ph)] were subjected to vector analysis using a custom-made mathematical program...
April 2018: Journal of Neural Transmission
Paul D Loprinzi, Megan M Danzl, Elizabeth Ulanowski, Calli Paydo
BACKGROUND: Few studies have examined the association between daily physical activity and cognitive function among older adults with Parkinson's disease (PD). OBJECTIVE: Here we evaluate the association between accelerometer-assessed physical activity and cognition among older patients with PD. METHODS: Cognition assessed via the Montreal Cognitive Assessment (MoCA). Moderate-to-vigorous physical activity (MVPA) was assessed via accelerometry over a 1-2 week monitoring period...
January 2018: Disability and Health Journal
Marie-Anne Gougeon, Lei Zhou, Julie Nantel
BACKGROUND: This study aimed to assess the effect of walking with Nordic Walking (NW) poles on postural stability and gait spatial-temporal characteristics in individuals with PD and to determine the cognitive load associated operating the poles. METHODS: Twelve individuals with PD (age: 61.6±11.7) were asked to perform four 90 s walking trials; with/without poles and with/without verbal fluency task (category fluency) after a 6-week independent NW training. We assessed gait spatial-temporal characteristics, and trunk postural stability using the APDM accelerometry system...
2017: NeuroRehabilitation
Aasef G Shaikh
Parkinson's disease, the most common cause of parkinsonism is often difficult to distinguish from its second most common etiology due to exposure to dopamine receptor blocking agents such as antiemetics and neuroleptics. Dual axis accelerometry was used to quantify tremor in 158 patients with parkinsonism; 62 had Parkinson's disease and 96 were clinically diagnosed with dopamine receptor blocking agent-induced parkinsonism. Tremor was measured while subjects rested arms (resting tremor), outstretched arms in front (postural tremor), and reached a target (kinetic tremor)...
May 2017: Neurological Sciences
Heidemarie Zach, Michiel F Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
AIMS: Resting tremor in Parkinson's disease (PD) increases markedly during cognitive stress. Dopamine depletion in the basal ganglia is involved in the pathophysiology of resting tremor, but it is unclear whether this contribution is altered under cognitive stress. We test the hypothesis that cognitive stress modulates the levodopa effect on resting tremor. METHODS: Tremulous PD patients (n = 69) were measured in two treatment conditions (OFF vs. ON levodopa) and in two behavioral contexts (rest vs...
March 2017: CNS Neuroscience & Therapeutics
Heidemarie Zach, Michiel Dirkx, Jaco W Pasman, Bastiaan R Bloem, Rick C Helmich
BACKGROUND: Dopaminergic medication adjustments in Parkinson's disease are often solely based on patient reports. However, it is unclear how well patient-based ratings of the levodopa response correlate with clinician-based ratings, and whether this correlation differs between motor symptoms. Here we compare patient-clinician agreement for the effect of levodopa on resting tremor and bradykinesia/rigidity. Furthermore, given patients' reports that tremor is most troublesome during stress, we test for differences in patient-clinician agreement between tremor at rest and stress-induced tremor...
February 2017: Parkinsonism & related Disorders
C Y Xu, H M Yin, B R Zhang
Objective: To investigate the electrophysiological features of tremor intensity, frequency and frequency dispersion of Parkinsonian (PT group) and essential (ET group) tremors using accelerometry. Methods: The amplitude, frequency and frequency dispersion of rest tremor, postural tremor and the influence of weight on tremor of 35 PT patients and 40 ET patients in Department of Neurology, the Second Affiliated Hospital Zhejiang University School of Medicine from May 2015 to April 2016 were retrospectively analyzed and compared...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Sarah J Ozinga, Susan M Linder, Jay L Alberts
OBJECTIVE: To determine the accuracy of inertial measurement unit data from a mobile device using the mobile device relative to posturography to quantify postural stability in individuals with Parkinson disease (PD). DESIGN: Criterion standard. SETTING: Motor control laboratory at a clinic. PARTICIPANTS: A sample (N=28) of individuals with mild to moderate PD (n=14) and age-matched community-dwelling individuals without PD (n=14) completed the study...
April 2017: Archives of Physical Medicine and Rehabilitation
Michelle Braybrook, Sam O'Connor, Philip Churchward, Thushara Perera, Parisa Farzanehfar, Malcolm Horne
BACKGROUND: While tremor in Parkinson's Disease (PD) can be characterised in the consulting room, its relationship to treatment and fluctuations can be clinically helpful. OBJECTIVE: To develop an ambulatory assessment of tremor of PD. METHODS: Accelerometry data was collected using the Parkinson's KinetiGraph System (PKG, Global Kinetics). An algorithm was developed, which could successfully distinguish been subjects with a resting or postural tremor that involved the wrist whose frequency was greater than 3 Hz...
October 19, 2016: Journal of Parkinson's Disease
Alexander P Turner, Michael A Lones, Martin A Trefzer, Stephen L Smith, Stuart Jamieson, Jane E Alty, Jeremy Cosgrove, Andy M Tyrrell
Levodopa is a drug that is commonly used to treat movement disorders associated with Parkinson's disease. Its dosage requires careful monitoring, since the required amount changes over time, and excess dosage can lead to muscle spasms known as levodopa-induced dyskinesia. In this work, we investigate the potential for using epiNet, a novel artificial gene regulatory network, as a classifier for monitoring accelerometry time series data collected from patients undergoing levodopa therapy. We also consider how dynamical analysis of epiNet classifiers and their transitions between different states can highlight clinically useful information which is not available through more conventional data mining techniques...
August 2016: Bio Systems
Ervin Sejdić, Kristin A Lowry, Jennica Bellanca, Subashan Perera, Mark S Redfern, Jennifer S Brach
OBJECTIVE: Evaluating stride events can be valuable for understanding the changes in walking due to aging and neurological diseases. However, creating the time series necessary for this analysis can be cumbersome. In particular, finding heel contact and toe-off events which define the gait cycles accurately are difficult. METHOD: We proposed a method to extract stride cycle events from tri-axial accelerometry signals. We validated our method via data collected from 14 healthy controls, 10 participants with Parkinson's disease and 11 participants with peripheral neuropathy...
2016: IEEE Journal of Translational Engineering in Health and Medicine
Nivedita Khobragade, Daniel Graupe, Daniela Tuninetti
This paper describes the application of the LAMSTAR (LArge Memory STorage and Retrieval) neural network for prediction of onset of tremor in Parkinson's disease (PD) patients to allow for on-off adaptive control of Deep Brain Stimulation (DBS). Currently, the therapeutic treatment of PD by DBS is an open-loop system where continuous stimulation is applied to a target area in the brain. This work demonstrates a fully automated closed-loop DBS system so that stimulation can be applied on-demand only when needed to treat PD symptoms...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mitsuru Yoneyama, Hiroshi Mitoma, Nobuo Sanjo, Maya Higuma, Hiroo Terashi, Takanori Yokota
Accelerometry-based gait analysis is a promising approach in obtaining insightful information on the gait characteristics of patients with neurological disorders such as dementia and Parkinson's disease (PD). In order to improve its practical use outside the laboratory or hospital, it is required to design new metrics capable of quantifying ambulatory gait and their extraction procedures from long-term acceleration data. This paper presents a gait analysis method developed for such a purpose. Our system is based on a single trunk-mounted accelerometer and analytical algorithm for the assessment of gait behavior that may be context dependent...
August 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
Thushara Perera, Shivanthan A C Yohanandan, Hugh J McDermott
Since the advent of electromyogram recording, precise measures of tremor and gait have been used to study movement disorders such as Parkinson's disease. Now, a wide range of accelerometers and other motion-tracking technologies exist to better inform researchers and clinicians, yet such systems are rarely tested for accuracy or suitability before use. Our inexpensive test-rig can produce sinusoidal displacements using a simple cantilever system driven by a subwoofer. Controlled sinusoids were generated using computer software, and the displacement amplitudes of the test-rig were verified with fiducial marker tracking...
March 2016: Medical & Biological Engineering & Computing
Alexandre Millecamps, Kristin A Lowry, Jennifer S Brach, Subashan Perera, Mark S Redfern, Ervin Sejdić
Gait accelerometry is an important approach for gait assessment. Previous contributions have adopted various pre-processing approaches for gait accelerometry signals, but none have thoroughly investigated the effects of such pre-processing operations on the obtained results. Therefore, this paper investigated the influence of pre-processing operations on signal features extracted from gait accelerometry signals. These signals were collected from 35 participants aged over 65years: 14 of them were healthy controls (HC), 10 had Parkinson׳s disease (PD) and 11 had peripheral neuropathy (PN)...
July 2015: Computers in Biology and Medicine
Malcolm K Horne, Sarah McGregor, Filip Bergquist
INTRODUCTION: Establishing the presence and severity of fluctuations is important in managing Parkinson's Disease yet there is no reliable, objective means of doing this. In this study we have evaluated a Fluctuation Score derived from variations in dyskinesia and bradykinesia scores produced by an accelerometry based system. METHODS: The Fluctuation Score was produced by summing the interquartile range of bradykinesia scores and dyskinesia scores produced every 2 minutes between 0900-1800 for at least 6 days by the accelerometry based system and expressing it as an algorithm...
2015: PloS One
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