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Balance and parkinson's disease

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https://www.readbyqxmd.com/read/28812419/the-effects-of-exergaming-and-treadmill-training-on-gait-balance-and-cognition-in-a-person-with-parkinson-s-disease-a-case-study
#1
Srikant Vallabhajosula, Amy K McMillion, Jane E Freund
BACKGROUND: Parkinson's disease (PD) commonly impairs posture, gait, and cognition. Exercise in the form of aerobic activity as well as exergaming may improve motor ability and cognition in persons with PD. Exergaming and treadmill training can be a practical form of exercise within the home; however, there is minimal research on this combined multimodal intervention for persons with PD. OBJECTIVE: We investigated the effects of this combined intervention on cognition, balance, and gait in a person with PD through supervised lab sessions augmented by home-based sessions...
August 16, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28805568/complementary-and-alternative-medicine-and-exercise-in-nonmotor-symptoms-of-parkinson-s-disease
#2
Indu Subramanian
The use of complementary and alternative medicine (CAM) therapy in nonmotor symptoms (NMS) for Parkinson disease (PD) is growing worldwide. Well-performed, systematic evidence-based research is largely lacking in this area and many studies include various forms of CAM with small patient numbers and a lack of standardization of the approaches studied. Taichi, Qigong, dance, yoga, mindfulness, acupuncture, and other CAM therapies are reviewed and there is some evidence for the following: Taichi in sleep and PDQ39; dance in cognition, apathy, and a mild trend to improved fatigue; yoga in PDQ39; and acupuncture in depression, PDQ39, and sleep...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28794981/a-test-retest-study-on-parkinson-s-ppmi-dataset-yields-statistically-significant-white-matter-fascicles
#3
Martin Cousineau, Pierre-Marc Jodoin, Félix C Morency, Verena Rozanski, Marilyn Grand'Maison, Barry J Bedell, Maxime Descoteaux
In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular resolution diffusion imaging (HARDI) crossing fiber modeling and tractography robust to partial volume effects, we automatically dissected 50 white matter (WM) fascicles. These fascicles connect deep nuclei (thalamus, putamen, pallidum) to different cortical functional areas (associative, motor, sensorimotor, limbic), basal forebrain and substantia nigra...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28793808/the-efficacy-and-feasibility-of-aquatic-physiotherapy-for-people-with-parkinson-s-disease-a-systematic-review
#4
Aan Fleur Terrens, Sze-Ee Soh, Prue Elizabeth Morgan
PURPOSE: To critically evaluate the literature regarding the efficacy and feasibility of aquatic physiotherapy in people with Parkinson's disease. METHOD: Relevant studies were identified through searches in nine health-related databases. Two independent reviewers assessed study quality using either the PEDro scale or a customised tool for safety and feasibility. RESULTS: Database searches yielded 88 articles, of which 10 met the inclusion criteria...
August 9, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28790972/investigation-of-anticipatory-postural-adjustments-during-one-leg-stance-using-inertial-sensors-evidence-from-subjects-with-parkinsonism
#5
Gianluca Bonora, Martina Mancini, Ilaria Carpinella, Lorenzo Chiari, Maurizio Ferrarin, John G Nutt, Fay B Horak
The One-Leg Stance (OLS) test is a widely adopted tool for the clinical assessment of balance in the elderly and in subjects with neurological disorders. It was previously showed that the ability to control anticipatory postural adjustments (APAs) prior to lifting one leg is significantly impaired by idiopathic Parkinson's disease (iPD). However, it is not known how APAs are affected by other types of parkinsonism, such as frontal gait disorders (FGD). In this study, an instrumented OLS test based on wearable inertial sensors is proposed to investigate both the initial anticipatory phase and the subsequent unipedal balance...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28790012/mdivi-1-ameliorates-early-brain-injury-after-subarachnoid-hemorrhage-via-the-suppression-of-inflammation-related-blood-brain-barrier-disruption-and-endoplasmic-reticulum-stress-based-apoptosis
#6
Lin-Feng Fan, Ping-You He, Yu-Cong Peng, Qing-Hua Du, Yi-Jun Ma, Jian-Xiang Jin, Hang-Zhe Xu, Jian-Ru Li, Zhi-Jiang Wang, Sheng-Long Cao, Tao Li, Feng Yan, Chi Gu, Lin Wang, Gao Chen
Aberrant modulation of mitochondrial dynamic network, which shifts the balance of fusion and fission towards fission, is involved in brain damage of various neurodegenerative diseases including Parkinson's disease, Huntington's disease and Alzheimer's disease. A recent research has shown that the inhibition of mitochondrial fission alleviates early brain injury after experimental subarachnoid hemorrhage, however, the underlying molecular mechanisms have remained to be elucidated. This study was undertaken to characterize the effects of the inhibition of dynamin-related protein-1 (Drp1, a dominator of mitochondrial fission) on blood-brain barrier (BBB) disruption and neuronal apoptosis following SAH and the potential mechanisms...
August 5, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28772130/action-observation-in-the-modification-of-postural-sway-and-gait-theory-and-use-in-rehabilitation
#7
REVIEW
Mitesh Patel
The discovery of cortical neurons responsive to both the observation of another individual's movement and one's own physical movement has spurred scientists into utilising this interplay for rehabilitation. The idea that humans can quickly transfer motor programmes or refine existing motor strategies through observation has only recently gained interest in the context of gait rehabilitation but may offer significant promise as an adjunctive therapy to routine balance training. This review is the first dedicated to action observation in postural control or gait in healthy individuals and patients...
July 24, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28760440/the-effect-of-electroacupuncture-on-proteomic-changes-in-the-motor-cortex-of-6-ohda-parkinsonian-rats
#8
Min Li, Lijuan Li, Ke Wang, Wenting Su, Jun Jia, Xiaomin Wang
Electroacupuncture (EA) has been reported to alleviate motor deficits in Parkinson's disease (PD) patients, and PD animal models. However, the mechanisms by which EA improves motor function have not been investigated. We have employed a 6-hydroxydopamine (6-OHDA) unilateral injection induced PD model to investigate whether EA alters protein expression in the motor cortex. We found that 4 weeks of EA treatment significantly improved spontaneous floor plane locomotion and rotarod performance. High-throughput proteomic analysis in the motor cortex was employed...
July 28, 2017: Brain Research
https://www.readbyqxmd.com/read/28758519/perturbation-during-treadmill-training-improves-dynamic-balance-and-gait-in-parkinson-s-disease-a-single-blind-randomized-controlled-pilot-trial
#9
Simon Steib, Sarah Klamroth, Heiko Gaßner, Cristian Pasluosta, Björn Eskofier, Jürgen Winkler, Jochen Klucken, Klaus Pfeifer
BACKGROUND: Gait and balance dysfunction are major symptoms in Parkinson's disease (PD). Treadmill training improves gait characteristics in this population but does not reflect the dynamic nature of controlling balance during ambulation in everyday life contexts. OBJECTIVE: To evaluate whether postural perturbations during treadmill walking lead to superior effects on gait and balance performance compared with standard treadmill training. METHODS: In this single-blind randomized controlled trial, 43 PD patients (Hoehn & Yahr stage 1-3...
July 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28752333/significance-of-long-chain-polyunsaturated-fatty-acids-in-human-health
#10
REVIEW
Rafael Zárate, Nabil El Jaber-Vazdekis, Noemi Tejera, José A Pérez, Covadonga Rodríguez
In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease. Of particular interest is the study of omega-3 and omega-6 long chain polyunsaturated fatty acids (LC-PUFAs), notably EPA (eicosapentaenoic acid, 20:5n-3), DHA (docosahexaenoic acid, 22:6n-3), and ARA (arachidonic acid, 20:4n-6), and their transformation into bioactive lipid mediators...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28749970/effectiveness-of-physical-activity-on-patients-with-depression-and-parkinson-s-disease-a-systematic-review
#11
Pei-Ling Wu, Megan Lee, Tzu-Ting Huang
AIM: In this paper we aimed to systematically review the literature on physical activity's effect on depressive symptoms in Parkinson disease. BACKGROUND: Depression is a common symptom of Parkinson's disease and is associated with increased disability, rapid progression of motor symptoms, mortality, and adverse effects on Quality of Life. DESIGN: A systematic review of primary research was undertaken and conducted according to the Preferred Reporting Items for Systematic Reviews...
2017: PloS One
https://www.readbyqxmd.com/read/28745063/home-based-step-training-using-videogame-technology-in-people-with-parkinson-s-disease-a-single-blinded-randomised-controlled-trial
#12
Jooeun Song, Serene S Paul, Maria Joana D Caetano, Stuart Smith, Leland E Dibble, Rachelle Love, Daniel Schoene, Jasmine C Menant, Cathie Sherrington, Stephen R Lord, Colleen G Canning, Natalie E Allen
OBJECTIVES: To determine whether 12-week home-based exergame step training can improve stepping performance, gait and complementary physical and neuropsychological measures associated with falls in Parkinson's disease. DESIGN: A single-blinded randomised controlled trial. SETTING: Community (experimental intervention), university laboratory (outcome measures). SUBJECTS: Sixty community-dwelling people with Parkinson's disease...
July 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28740852/body-posture-postural-stability-and-metabolic-age-in-patients-with-parkinson-s-disease
#13
Jacek Wilczyński, Agnieszka Pedrycz, Dariusz Mucha, Tadeusz Ambroży, Dawid Mucha
BACKGROUND: The study aims to analyze the relationship between body posture and composition, as well as postural stability in Parkinson's disease patients. MATERIAL AND METHODS: 32 people were evaluated. The study was conducted in the Laboratory of Posturology at Jan Kochanowski University in Kielce (Poland). Body posture was examined using the optoelectronic body posture Formetric Diers Method III 4D. Postural stability was evaluated using the Biodex Balance System platform...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28735833/cannabis-use-in-people-with-parkinson-s-disease-and-multiple-sclerosis-a-web-based-investigation
#14
John H Kindred, Kaigang Li, Nathaniel B Ketelhut, Felix Proessl, Brett W Fling, Justin M Honce, William R Shaffer, Thorsten Rudroff
OBJECTIVES: Cannabis has been used for medicinal purpose for thousands of years; however the positive and negative effects of cannabis use in Parkinson's disease (PD) and Multiple Sclerosis (MS) are mostly unknown. Our aim was to assess cannabis use in PD and MS and compare results of self-reported assessments of neurological disability between current cannabis users and non-users. METHODS: An anonymous web-based survey was hosted on the Michael J. Fox Foundation and the National Multiple Sclerosis Society webpages from 15 February to 15 October 2016...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28716283/dalfampridine-in-parkinson-s-disease-related-gait-dysfunction-a-randomized-double-blind-trial
#15
Corneliu C Luca, Gloria Nadayil, Chuanhui Dong, Fatta B Nahab, Edelle Field-Fote, Carlos Singer
BACKGROUND: Disease-related gait dysfunction causes extensive disability for persons with Parkinson's disease (PD), with no effective therapies currently available. The potassium channel blocker dalfampridine has been used in multiple neurological conditions and improves walking in persons with multiple sclerosis. OBJECTIVES: We aimed to evaluate the effect of dalfampridine extended release (D-ER) 10mg tablets twice daily on different domains of walking in participants with PD...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28715936/selection-of-gait-parameters-for-differential-diagnostics-of-patients-with-de-novo-parkinson-s-disease
#16
Milica Djurić-Jovičić, Minja Belić, Iva Stanković, Saša Radovanović, Vladimir S Kostić
BACKGROUND: Gait disturbances are an integral part of clinical manifestations of Parkinson's disease (PD), even in the initial stages of the disease. Our goal was to identify the set of spatio-temporal gait parameters that bear the highest relevance for characterizing de novo PD patients. METHODS: Forty patients with de novo PD and forty healthy controls were recorded while walking over an electronic walkway in three different conditions: (1) base walking, (2) walking with an additional motor task, (3) walking with an additional mental task...
July 17, 2017: Neurological Research
https://www.readbyqxmd.com/read/28714199/the-effect-of-dopaminergic-medication-on-conflict-adaptation-in-parkinson-s-disease
#17
Marit F L Ruitenberg, Elger L Abrahamse, Patrick Santens, Wim Notebaert
Parkinson's disease (PD) is a neurological disorder associated primarily with motor symptoms such as tremor, slowness of movement, and difficulties with gait and balance. Most patients take dopaminergic medication to improve their motor functions. Previous studies reported indications that such medication can impair higher cognitive functions (cf. dopamine overdose hypothesis). In the present study, we examined the effect of medication status on conflict adaptation. PD patients performed a Stroop task in which we manipulated the proportion of congruent and incongruent items, thereby allowing us to explore conflict adaptation...
July 16, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28712331/feasibility-and-efficacy-of-mat-pilates-on-people-with-mild-to-moderate-parkinson-s-disease-a-preliminary-study
#18
Jose Maria Cancela, Irimia Mollinedo, Carlos Ayán Perez, Iris Machado de Oliveira
OBJECTIVES: This pilot study aimed at assessing the feasibility and efficacy of a Mat Pilates program in people with mild to moderate Parkinson's disease. Equipment and methods: The participants carried out a Mat Pilates program twice a week for 12 weeks. The Senior Fitness Test battery and the 39-item Parkinson's Disease Questionnaire were used to assess the effects of the program on the participants' fitness level and quality of life. RESULTS: A total of 16 patients with mild to moderate Parkinson's disease volunteered and finished the study...
July 16, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28698377/monomeric-and-fibrillar-%C3%AE-synuclein-exert-opposite-effects-on-the-catalytic-cycle-that-promotes-the-proliferation-of-a%C3%AE-42-aggregates
#19
Sean Chia, Patrick Flagmeier, Johnny Habchi, Veronica Lattanzi, Sara Linse, Christopher M Dobson, Tuomas P J Knowles, Michele Vendruscolo
The coaggregation of the amyloid-β peptide (Aβ) and α-synuclein is commonly observed in a range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. The complex interplay between Aβ and α-synuclein has led to seemingly contradictory results on whether α-synuclein promotes or inhibits Aβ aggregation. Here, we show how these conflicts can be rationalized and resolved by demonstrating that different structural forms of α-synuclein exert different effects on Aβ aggregation. Our results demonstrate that whereas monomeric α-synuclein blocks the autocatalytic proliferation of Aβ42 (the 42-residue form of Aβ) fibrils, fibrillar α-synuclein catalyses the heterogeneous nucleation of Aβ42 aggregates...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28697798/a-proteomic-analysis-of-lrrk2-binding-partners-reveals-interactions-with-multiple-signaling-components-of-the-wnt-pcp-pathway
#20
Alena Salašová, Chika Yokota, David Potěšil, Zbyněk Zdráhal, Vítězslav Bryja, Ernest Arenas
BACKGROUND: Autosomal-dominant mutations in the Park8 gene encoding Leucine-rich repeat kinase 2 (LRRK2) have been identified to cause up to 40% of the genetic forms of Parkinson's disease. However, the function and molecular pathways regulated by LRRK2 are largely unknown. It has been shown that LRRK2 serves as a scaffold during activation of WNT/β-catenin signaling via its interaction with the β-catenin destruction complex, DVL1-3 and LRP6. In this study, we examine whether LRRK2 also interacts with signaling components of the WNT/Planar Cell Polarity (WNT/PCP) pathway, which controls the maturation of substantia nigra dopaminergic neurons, the main cell type lost in Parkinson's disease patients...
July 11, 2017: Molecular Neurodegeneration
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