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Balance and parkinson's disease

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https://www.readbyqxmd.com/read/28097926/a-pilot-study-of-a-minimally-supervised-home-exercise-and-walking-program-for-people-with-parkinson-s-disease-in-jordan
#1
Hanan Khalil, Monica Busse, Lori Quinn, Mohammad Nazzal, Waleed Batyha, Shatha Alkhazaleh, Mahmoud A Alomari
AIM: This study aimed to evaluate the feasibility and cultural considerations of a minimally supervised, home-based exercise program in Jordan. METHODS: Quantitative and qualitative approaches were used. Thirty participants were randomly allocated to either an 8-week intervention group (n = 16), or a standard care group (n = 14). The intervention incorporated the home use of an exercise DVD, walking program and initial instructional sessions and weekly phone calls provided by a physiotherapist...
January 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28088064/improved-cognition-while-cycling-in-parkinson-s-disease-patients-and-healthy-adults
#2
Audrey A Hazamy, Lori J P Altmann, Elizabeth Stegemöller, Dawn Bowers, Hyo Keun Lee, Jonathan Wilson, Michael S Okun, Chris J Hass
Persons with Parkinson's disease (PD) are typically more susceptible than healthy adults to impaired performance when two tasks (dual task interference) are performed simultaneously. This limitation has by many experts been attributed to limitations in cognitive resources. Nearly all studies of dual task performance in PD employ walking or balance-based motor tasks, which are commonly impaired in PD. These tasks can be performed using a combination of one or two executive function tasks. The current study examined whether persons with PD would demonstrate greater dual task effects (DTEs) on cognition compared to healthy older adults (HOAs) during a concurrent cycling task...
January 11, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28067072/drug-target-identification-at-the-crossroad-of-neuronal-apoptosis-and-survival
#3
Barbara Maino, Simona Paparone, Cinzia Severini, Maria Teresa Ciotti, Velia D'Agata, Pietro Calissano, Sebastiano Cavallaro
Inappropriate activation of apoptosis may contribute to neurodegeneration, a multifaceted process that results in various chronic disorders, including Alzheimer's and Parkinson's diseases. Several in vitro and in vivo studies demonstrated that neuronal apoptosis is a multi-pathway cell-death program that requires RNA synthesis. Thus, transcriptionally activated genes whose products induce cell death can be triggered by different stimuli and antagonized by neurotrophic factors. Systems biology is now unveiling the series of intracellular signaling pathways and key drug targets at the intersection of neuronal apoptosis and survival...
January 8, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28061431/effect-of-subthalamic-nucleus-deep-brain-stimulation-on-balance-in-parkinson-s-disease-a-static-posturographic-analysis
#4
Beatriz De la Casa-Fages, Fernando Alonso-Frech, Francisco Grandas
BACKGROUND: The effect of subthalamic deep brain stimulation on balance in Parkinson's disease remains unclear. OBJECTIVE: To evaluate the effect of subthalamic nucleus stimulation on balance in Parkinson's disease using posturography. METHODS: 16 patients (9 women) who underwent subthalamic deep brain stimulation [mean age 59.6 years (46-70); mean disease duration 15.6 years (7-25); mean duration of subthalamic stimulation 32.1 months (3...
December 29, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28052701/potential-for-targeting-dopamine-darpp-32-signaling-in-neuropsychiatric-and-neurodegenerative-disorders
#5
Akinori Nishi, Takahide Shuto
Alterations in dopamine neurotransmission has been implicated in pathophysiology of neuropsychiatric and neurodegenerative disorders, and DARPP-32 plays a pivotal role in dopamine neurotransmission. DARPP-32 likely influences dopamine-mediated behaviors in animal models of neuropsychiatric and neurodegenerative disorders and therapeutic effects of pharmacological treatment. Areas covered: We will review animal studies on the biochemical and behavioral roles of DARPP-32 in drug addiction, schizophrenia and Parkinson's disease...
January 13, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28049396/oxidative-stress-and-antioxidant-potential-of-one-hundred-medicinal-plants
#6
Waseem Hassan, Hamsa Noreen, Shakila Rehman, Shehnaz Gul, Mohammad Amjad Kamal, Jean Paul Kamdem, Bakht Zaman, Joao B T da Rocha
Reactive species are produced in biological system because of redox reactions. The imbalance in pro-oxidant and antioxidant homeostasis leads to the production of toxic reactive oxygen and nitrogen species like hydrogen peroxide, organic peroxides, hydroxyl radicals, superoxide anion and nitric oxide. Inactivation of metabolic enzymes, oxidation of biomolecules and cellular damage are some of the prominent characteristics of reactive species. Similarly, oxidative stress has been associated with more than one hundred (100) pathologies such as atherosclerosis, diabetes, cardiovascular diseases, pancreatic and liver diseases, joint disorders, cardiac fibrosis, acute respiratory distress syndrome, neurological diseases (amyotrophic lateral sclerosis, Huntington's disorder, Parkinson's disease and Alzheimer's disease), ageing and cancer etc...
January 2, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28028942/effects-of-propofol-on-the-liver-oxidative-antioxidant-balance-in-a-rat-model-of-parkinson-s-disease
#7
Ewa B Romuk, Wioletta Szczurek, Przemysław G Nowak, Edyta Hudziec, Ewa Chwalińska, Ewa Birkner
BACKGROUND: Parkinson's disease is caused by the destruction of dopaminergic neurons in the substantia nigra of the midbrain. One of the possible factors involved in the pathogenesis of Parkinson's disease is impaired oxidativeantioxidative balance. OBJECTIVES: The present study aimed to evaluate selected parameters of the liver oxidative-antioxidative system in a Wistar rat model with Parkinson's disease treated with propofol. MATERIAL AND METHODS: Experiments were performed on 32 rats divided into 4 groups: 1 - control, 2 - Parkinson's disease, 3 - control with propofol, 4 - Parkinson's disease with propofol...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28027505/impairment-of-dynamic-thiol-disulphide-homeostasis-in-patients-with-idiopathic-parkinson-s-disease-and-its-relationship-with-clinical-stage-of-disease
#8
Gonul Vural, Sadiye Gumusyayla, Hesna Bektas, Orhan Deniz, Murat Alisik, Ozcan Erel
OBJECTIVE: The aim of this study was to investigate dynamic thiol-disulphide homeostasis in patients with idiopathic Parkinson's disease and to determine its relationship with the clinical stage as assessed by the modified Hoehn and Yahr scale. DESIGN AND METHODS: Fifty-two patients with Parkinson's disease (PD), diagnosed according to the United Kingdom Brain Bank Criteria for idiopathic PD, and 41 healthy individuals were included in the study. Clinical staging of patients was performed according to the Hoehn and Yahr scale...
December 23, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28000926/virtual-reality-for-rehabilitation-in-parkinson-s-disease
#9
REVIEW
Kim Dockx, Esther Mj Bekkers, Veerle Van den Bergh, Pieter Ginis, Lynn Rochester, Jeffrey M Hausdorff, Anat Mirelman, Alice Nieuwboer
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder that is best managed by a combination of medication and regular physiotherapy. In this context, virtual reality (VR) technology is proposed as a new rehabilitation tool with a possible added value over traditional physiotherapy approaches. It potentially optimises motor learning in a safe environment, and by replicating real-life scenarios could help improve functional activities of daily living. OBJECTIVES: The objective of this review was to summarise the current best evidence for the effectiveness of VR interventions for the rehabilitation of people with PD in comparison with 1) active interventions, and 2) passive interventions...
December 21, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27993586/imposed-faster-and-slower-walking-speeds-influence-gait-stability-differently-in-parkinson-fallers
#10
Michael H Cole, Matthew Sweeney, Zachary J Conway, Tim Blackmore, Peter A Silburn
OBJECTIVE: This cross-sectional study sought to evaluate the effect of imposed faster and slower walking speeds on postural stability in people with Parkinson's disease (PD). DESIGN: Cross-sectional cohort study; SETTING: General community PARTICIPANTS: 84 PD patients (51 with a falls history; 33 without) and 82 age-matched controls were invited to participate via neurology clinics and pre-existing databases. Of those contacted, 99 did not respond (PD=36; controls=63) and 27 were not interested (PD=18; controls=9)...
December 16, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27990316/subthalamus-stimulation-in-parkinson-disease-accounting-for-the-bilaterality-of-contacts
#11
Jean-Jacques Lemaire, Bruno Pereira, Philippe Derost, François Vassal, Miguel Ulla, Dominique Morand, Guillaume Coll, Jean Gabrillargues, Ana Marques, Bérangère Debilly, Jérôme Coste, Franck Durif
BACKGROUND: Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy. METHODS: Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27986997/risk-of-parkinsonism-induced-by-flunarizine-or-cinnarizine-a-population-based-study
#12
Hsiu-Li Lin, Hsiu-Chen Lin, Yuan-Fu Tseng, Shih-Chang Chen, Chien-Yeh Hsu
PURPOSE: This retrospective cohort study used a population-based dataset to test the risk for parkinsonism in patients receiving flunarizine and cinnarizine, compared with matched controls. METHODS: Data were obtained from the National Health Insurance Research Dataset of Taiwan. Patients receiving flunarizine or cinnarizine for more than 1 month between 2000 and 2005 were enrolled. Exclusion criteria included receiving flunarizine, cinnarizine, or antipsychotics for more than 1 month during 1997-1999, a history of neurodegenerative diseases, and an age of less than 30 years...
December 16, 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27984168/the-protective-mechanism-of-docosahexaenoic-acid-in-mouse-model-of-parkinson-the-role-of-hemeoxygenase
#13
Ayse Ozkan, Hande Parlak, Gamze Tanriover, Sayra Dilmac, Seher Nasircilar Ulker, Llknur Birsen, Aysel Agar
Parkinson's disease (PD) is characterized by degeneration of the dopaminergic neurons in substantia nigra (SN). Its major clinical symptoms are tremor, rigidity, bradykinesia and postural instability. Docosahexaenoic acid (DHA) is an essential fatty acid for neural functions that resides within the neural membrane. A decline in fatty acid concentration is observed in case of neurodegenerative diseases such as PD. The present study aimed to explore the role of the heme oxygenase (HO) enzyme in protective effects of DHA administration in an experimental model of PD by using the neurotoxin 1-Methly-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
October 27, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27984031/polestriding-intervention-improves-gait-and-axial-symptoms-in-mild-to-moderate-parkinson-s-disease
#14
Narayanan Krishnamurthi, Holly Shill, Darolyn O'Donnell, Padma Mahant, Johan Samanta, Abraham Lieberman, James Abbas
OBJECTIVE: To evaluate the effects of 12-week polestriding intervention on gait and disease severity in people with mild to moderate Parkinson's disease DESIGN: A-B-A withdrawal study design SETTING: Outpatient movement disorder center and community facility. PARTICIPANTS: Individuals (9 females and 8 males; mean age: 63.7 ± 4.9 years; range 53 - 72 years) with mild to moderate PD according to UK brain bank criteria with Hoehn and Yahr (H&Y) score from 2.5 to 3...
October 27, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27977521/exploring-the-effects-of-using-an-oral-appliance-to-reduce-movement-dysfunction-in-an-individual-with-parkinson-disease-a-single-subject-design-study
#15
Hillary Lane, Lindsey E Rose, Megan Woodbrey, David Arghavani, Michael Lawrence, James T Cavanaugh
BACKGROUND AND PURPOSE: Clinical reports suggest that wearing an oral appliance can improve the gait and balance of an individual with Parkinson disease (PD). Our primary purpose was to systematically explore this effect using a single-subject study design and quantitative motion analysis. Secondarily, we sought to examine the quality-of-life outcomes following 1-month of routine oral appliance wear. METHODS: The participant was a 73-year-old ambulatory man with mid-stage PD...
January 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/27977519/a-cross-sectional-analysis-of-the-characteristics-of-individuals-with-parkinson-disease-who-avoid-activities-and-participation-due-to-fear-of-falling
#16
Merrill R Landers, Morgan Lopker, Molly Newman, Russell Gourlie, Spencer Sorensen, Rithea Vong
BACKGROUND AND PURPOSE: Avoidance behavior can have deleterious consequences on health and quality of life for persons with Parkinson disease (PD); for this reason, it is important to identify potentially mitigable characteristics. We compared the characteristics of individuals with PD who exhibit fear of falling (FOF) avoidance behavior with those who do not. METHODS: Fifty-nine participants with PD were classified as avoiders (n = 27) or nonavoiders (n = 32) by using the Fear of Falling Avoidance Behavior Questionnaire and compared across 5 domains: demographic characteristics; PD-specific symptoms (subtype, Movement Disorder Society-Unified Parkinson's Disease Rating Scale [MDS-UPDRS], Hoehn and Yahr Scale, Parkinson's Disease Questionnaire-39 [PDQ-39]); balance and falls (fall history, Berg Balance Scale [BBS], Activities-Specific Balance Confidence [ABC] Scale, Impact of Events Scale, Consequences of Falling Questionnaire [CoFQ]); physical performance (30 Second Sit-to-Stand Test, Timed Up and Go Test, physical activity monitoring); and psychological factors (Zung Anxiety Scale, Beck Depression Inventory [BDI])...
January 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/27977464/clinical-utility-of-the-6-min-walk-test-for-patients-with-moderate-parkinson-s-disease
#17
Eiji Kobayashi, Nobuaki Himuro, Mitsuhiko Takahashi
The aim of this study was to test the clinical utility of the 6-min walk test (6MWT) for patients with moderate Parkinson's disease (PD) through a determination of factors related to this test. This was a descriptive, observational study carried out at a General Hospital, in-patients. Twenty-four patients with moderate PD were studied. We used Hoehn and Yahr stage ratings (HY stage), Unified Parkinson Disease Rating Scales (UPDRS) motor examination score, 6MWT, Berg Balance scale, Timed 'Up & Go' test (TUG), 10-m walk test (10-m walk speed, 10-m walk steps and cadence), and the energy cost of walking (Ec)...
December 13, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/27975173/acetyl-l-carnitine-via-upegulating-dopamine-d1-receptor-and-attenuating-microglial-activation-prevents-neuronal-loss-and-improves-memory-functions-in-parkinsonian-rats
#18
Sonu Singh, Akanksha Mishra, Neha Srivastava, Rakesh Shukla, Shubha Shukla
Parkinson's disease is accompanied by nonmotor symptoms including cognitive impairment, which precede the onset of motor symptoms in patients and are regulated by dopamine (DA) receptors and the mesocorticolimbic pathway. The relative contribution of DA receptors and astrocytic glutamate transporter (GLT-1) in cognitive functions is largely unexplored. Similarly, whether microglia-derived increased immune response affects cognitive functions and neuronal survival is not yet understood. We have investigated the effect of acetyl-L-carnitine (ALCAR) on cognitive functions and its possible underlying mechanism of action in 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonian rats...
December 14, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27965005/wearable-sensor-based-biofeedback-training-for-balance-and-gait-in-parkinson-s-disease-a-pilot-randomized-controlled-trial
#19
Ilaria Carpinella, Davide Cattaneo, Gianluca Bonora, Thomas Bowman, Laura Martina, Angelo Montesano, Maurizio Ferrarin
OBJECTIVES: To analyze the feasibility and efficacy of a novel system (Gamepad) for biofeedback rehabilitation in Parkinson's Disease (PD). It is hypothesized that Gamepad-based training is feasible and provides larger improvements of balance and gait, compared to physiotherapy without biofeedback. DESIGN: Randomized controlled trial. SETTINGS: Clinical rehabilitation gym. PARTICIPANTS: Forty-two PD subjects randomized into Experimental (EG) and Control Group (CG)...
December 10, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27914023/reliability-and-validity-of-the-persian-translation-of-berg-balance-scale-in-parkinson-disease
#20
Arash Babaei-Ghazani, Hosein Mohammadi, Gholam Ali Shahidi, Seyed Amir Hasan Habibi, Bijan Forogh, Tannaz Ahadi, Bina Eftekharsadat
PURPOSE: Parkinson disease (PD) is one of the common causes of imbalance, and the balance assessment is necessary for treatment and rehabilitation of these patients. The Berg Balance Scale (BBS) has been the main instrument used to evaluate balance impairment. The purpose of this study is to investigate reliability and validity of the Persian translation of BBS in Parkinson disease. METHODS: One hundred PD patients (with mean age of 56.8 ± 15.13 years) were included...
December 2, 2016: Aging Clinical and Experimental Research
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