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Balance and parkinson's disease

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https://www.readbyqxmd.com/read/28433105/symptomatic-treatment-of-neurologic-symptoms-in-wilson-disease
#1
Tomasz Litwin, Petr Dušek, Anna Członkowska
Wilson disease (WD) is a potentially treatable neurodegenerative disorder. In the majority of cases, treatment with drugs that induce a negative copper balance (usually chelators or zinc salts) leads to improvements in liver function and neurologic signs. However, some patients show severe neurologic symptoms at diagnosis, such as tremor, dystonia, parkinsonism, and chorea. In this patient group, some neurologic deficits may persist despite adequate treatment, and further neurologic deterioration may be observed after treatment initiation...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28395171/the-validity-of-the-gait-variability-index-for-individuals-with-mild-to-moderate-parkinson-s-disease
#2
Linda Rennie, Espen Dietrichs, Rolf Moe-Nilssen, Arve Opheim, Erika Franzén
Increased step-to-step variability is a feature of gait in individuals with Parkinson's disease (PD) and is associated with increased disease severity and reductions in balance and mobility. The Gait Variability Index (GVI) quantifies gait variability in spatiotemporal variables where a score ≥100 indicates a similar level of gait variability as the control group, and lower scores denote increased gait variability. The study aim was to explore mean GVI score and investigate construct validity of the index for individuals with mild to moderate PD...
March 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28393348/housing-accessibility-problems-for-people-with-parkinson-s-disease
#3
B Slaug, S Iwarsson, J A Ayala, M H Nilsson
OBJECTIVES: Promoting accessible housing for all citizens is high on the political agenda. Knowledge is, however, limited regarding housing accessibility problems for people with Parkinson's disease (PD). The objectives were to investigate housing accessibility problems among people with PD at different stages of disease severity and to analyze the potential impact of improved functional ability on accessibility problems. MATERIALS AND METHODS: The study included 253 participants with PD (61% men; mean age 70 years)...
April 9, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28381488/increased-neuromuscular-consistency-in-gait-and-balance-after-partnered-dance-based-rehabilitation-in-parkinson-s-disease
#4
Jessica L Allen, J Lucas McKay, Andrew Sawers, Madeleine Eve Hackney, Lena H Ting
Here we examined changes in muscle coordination associated with improved motor performance after partnered, dance-based rehabilitation in individuals with mild-moderate idiopathic Parkinson's disease. Using motor module (a.k.a muscle synergy) analysis we identified changes in the modular control of overground walking and standing reactive balance that accompanied clinically meaningful improvements on behavioral measures of balance, gait, and disease symptoms after three-weeks of daily Adapted Tango classes...
April 5, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28373849/deep-brain-stimulation-in-anorexia-nervosa-hope-for-the-hopeless-or-exploitation-of-the-vulnerable-the-oxford-neuroethics-gold-standard-framework
#5
Rebecca J Park, Ilina Singh, Alexandra C Pike, Jacinta O A Tan
Neurosurgical interventions for psychiatric disorders have a long and troubled history (1, 2) but have become much more refined in the last few decades due to the rapid development of neuroimaging and robotic technologies (2). These advances have enabled the design of less invasive techniques, which are more focused, such as deep brain stimulation (DBS) (3). DBS involves electrode insertion into specific neural targets implicated in pathological behavior, which are then repeatedly stimulated at adjustable frequencies...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28365858/sagittal-balance-is-correlated-with-parkinson-s-disease-clinical-parameters-an-overview-of-spinopelvic-alignment-on-175-consecutive-cases
#6
Luciano Bissolotti, Pedro Berjano, Paola Zuccher, Andrea Zenorini, Riccardo Buraschi, Jorge Hugo Villafañe, Stefano Negrini
PURPOSE: The aim of this study was to describe the disease-related sagittal balance changes in relation to the sacro-pelvic morphology of Parkinson's Disease patients with different duration of disease. METHODS: One hundred and seventy-five consecutive Parkinson's Disease (PD) patients (102 males, 73 females; age: 55-83 years) participated in the cross-sectional study. The clinical assessment included: Hoehn Yahr (H&Y) score; Tinetti score; plumb line (PL) distance from the spinous process of C7, L3 and S1 and kyphosis apex...
April 1, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28364292/continuous-subcutaneous-apomorphine-infusion-in-advanced-parkinson-s-disease-10-year-experience-with-230-patients
#7
Ángel Sesar, Gustavo Fernández-Pajarín, Begoña Ares, María Teresa Rivas, Alfonso Castro
Continuous apomorphine infusion (APO) is one of the treatments available for advanced Parkinson disease (PD). Over 10 years, we have treated 230 patients with APO. Mean age was 66.8 and average evolution time at APO onset was 13.0 years. Mean duration of the treatment was 26.3 months. As of June 2016, 93 remained on the medication (active group), while 137 had stopped. This active group had mean age 67.3 at recruitment and mean evolution 14.2 years. The main indication for APO was lack of deep brain stimulation criteria (DBS)...
March 31, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28361249/does-trajectory-matter-a-study-looking-into-the-relationship-of-trajectory-with-target-engagement-and-error-accommodation-in-subthalamic-nucleus-deep-brain-stimulation
#8
David Anthony Steel, Surajit Basu
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is now a key treatment choice for advanced Parkinson's disease. The optimum target area within the STN is well established. However, no emphasis on the impact of trajectory exists. The ellipsoid shape of the STN and the off-centre traditional target point mean that variation in the electrode inclination should affect STN engagement. Understanding of this relationship could inform trajectory selection during planning by improving STN engagements and margins for error...
March 30, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28350890/quantification-of-motor-network-dynamics-in-parkinson-s-disease-by-means-of-landscape-and-flux-theory
#9
Han Yan, Jin Wang
The basal ganglia neural circuit plays an important role in motor control. Despite the significant efforts, the understanding of the principles and underlying mechanisms of this modulatory circuit and the emergence of abnormal synchronized oscillations in movement disorders is still challenging. Dopamine loss has been proved to be responsible for Parkinson's disease. We quantitatively described the dynamics of the basal ganglia-thalamo-cortical circuit in Parkinson's disease in terms of the emergence of both abnormal firing rates and firing patterns in the circuit...
2017: PloS One
https://www.readbyqxmd.com/read/28349030/treadmill-exercise-alleviates-nigrostriatal-dopaminergic-loss-of-neurons-and-fibers-in-rotenone-induced-parkinson-rats
#10
Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Eun-Sang Ji, Baek-Vin Lim
Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exercise on motor performance, dopaminergic loss of neurons and fibers, and α-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the induction of Parkinson rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running was conducted for 30 min once a day during 14 consecutive days...
February 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28331638/effect-on-gait-speed-balance-motor-symptom-rating-and-quality-of-life-in-those-with-stage-i-parkinson-s-disease-utilizing-lsvt-big%C3%A2
#11
Beth Millage, Erin Vesey, Marsha Finkelstein, Mattie Anheluk
Individuals with Parkinson's Disease (PD) are often not referred to Physical Therapy (PT) until there are issues with mobility in later Hoehn and Yahr Stages. There have been no studies outlining the benefits of PT intervention in Stage I only. For persons with PD, deficits in motor function increase over time due to destruction of dopamine-producing cells. LSVT BIG, an exercise program for PD, has been shown to be effective in improving mobility. The purpose of this study was to assess participants functional improvement at a level of minimal clinically important difference (MCID) in one of four outcome measures: Gait Speed, Berg Balance Assessment, Functional Gait Assessment, and Unified Parkinson's Disease Rating Scale Motor Section...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28286168/predcar-site-carbonylation-sites-prediction-in-proteins-using-support-vector-machine-with-resolving-data-imbalanced-issue
#12
Md Al Mehedi Hasan, Jinyan Li, Shamim Ahmad, Md Khademul Islam Molla
The carbonylation is found as an irreversible post-translational modification and considered a biomarker of oxidative stress. It plays major role not only in orchestrating various biological processes but also associated with some diseases such as Alzheimer's disease, diabetes, and Parkinson's disease. However, since the experimental technologies are costly and time-consuming to detect the carbonylation sites in proteins, an accurate computational method for predicting carbonylation sites is an urgent issue which can be useful for drug development...
March 9, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28285031/evolution-and-complications-after-surgery-for-spine-deformation-in-patients-with-parkinson-s-disease
#13
Bouyer Benjamin, Scemama Caroline, P Roussouly, F Laouissat, I Obeid, L Boissière, F-H Parent, S Schuller, J-P Steib, H Pascal-Moussellard, P Guigui, Wolff Stéphane, Riouallon Guillaume
INTRODUCTION: Surgical treatment of spinal deformity is high risk in patients suffering from Parkinson's disease (PD). Several series have already reported a high rate of complications. However, none of these studies included more than 40 patients and none of the risk factors of complications were described. The aim of this study was to describe the rate and risk factors of revision surgery as well as the clinical outcome at the last visit in a large multicenter study of PD patients operated for spinal deformities...
March 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28281005/a-clinical-study-of-the-coronal-plane-deformity-in-parkinson-disease
#14
Xiaoyun Ye, Danning Lou, Xueping Ding, Chaoyan Xie, Jixiang Gao, Yuting Lou, Zhidong Cen, Yuxiang Xiao, Qianzhuang Miao, Fei Xie, Xiaosheng Zheng, Jianxin Wu, Fangcai Li, Wei Luo
BACKGROUND: Postural deformities in the coronal plane were frequent and disabling complications of PD, which reduces the quality of life of patients. This study aimed to garner greater attention to the Parkinson disease (PD)-related postural trunk deviations in the coronal plane by exploring a method for diagnosis because of the lack of any uniform diagnostic criteria and epidemiological studies. It also aimed to provide correlation data in the Chinese PD patients. METHODS: In this cross-sectional study, 503 consecutive outpatients with PD were enrolled who underwent standardized clinical evaluation...
March 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28275542/parkinson-s-disease-diffusion-mri-is-not-affected-by-acute-antiparkinsonian-medication
#15
Jae Woo Chung, Roxana G Burciu, Edward Ofori, Priyank Shukla, Michael S Okun, Christopher W Hess, David E Vaillancourt
OBJECTIVE: A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. METHODS: Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45 min after their usual dose of antiparkinsonian medication...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28274814/the-role-of-aquaporin-4-in-synaptic-plasticity-memory-and-disease
#16
REVIEW
Jacqueline A Hubbard, Jenny I Szu, Devin K Binder
Since the discovery of aquaporins, it has become clear that the various mammalian aquaporins play critical physiological roles in water and ion balance in multiple tissues. Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis. In this review, we summarize new and exciting studies indicating that AQP4 also plays critical and unanticipated roles in synaptic plasticity and memory formation. Next, we consider the role of AQP4 in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), neuromyelitis optica (NMO), epilepsy, traumatic brain injury (TBI), and stroke...
March 6, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28270047/instruction-prioritization-in-task-based-balance-training-for-individuals-with-idiopathic-parkinson-s-disease
#17
Vaithiamanithi Perumal, Ganeswara Rao Melam, Adel A Alhusaini, Syamala Buragadda, Neha Sharma
The objective of the study was to evaluate the effect of prioritization of instruction in balance training for individuals with Parkinson's disease (PD). Thirty-six participants were evaluated before and after the training using the Berg Balance Scale, Dynamic Gait Index, and Geriatric Depression Scale. Results show that dual task training with variable priority instruction is as effective as single task training in improving the balance performance of individuals with idiopathic PD.
March 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28268966/attractor-shape-descriptors-for-balance-impairment-assessment-in-parkinson-s-disease
#18
Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga
In this paper, we propose a computational framework using high-dimensional shape descriptors of reconstructed attractors of center-of-pressure (CoP) tracings collected from subjects with Parkinson's disease while performing dynamical posture shifts, to quantitatively assess balance impairment. Using a dataset collected from 60 subjects, we demonstrated that the proposed method outperforms traditional methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263252/flexed-truncal-posture-in-parkinson-disease-measurement-reliability-and-relationship-with-physical-and-cognitive-impairments-mobility-and-balance
#19
Aimi L Forsyth, Serene S Paul, Natalie E Allen, Catherine Sherrington, Victor S C Fung, Colleen G Canning
BACKGROUND AND PURPOSE: Flexed truncal posture is common in people with Parkinson disease (PD); however, little is known about the mechanisms responsible or its effect on physical performance. This cross-sectional study aimed to establish the reliability of a truncal posture measurement and explore relationships between PD impairments and truncal posture, as well as truncal posture and balance and mobility. METHODS: A total of 82 people with PD participated. Truncal posture was measured in standing as the distance between vertebra C7 and a wall...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28258168/inhibition-of-l-type-ca-2-channels-by-trpc1-stim1-complex-is-essential-for-the-protection-of-dopaminergic-neurons
#20
Yuyang Sun, Haopeng Zhang, Senthil Selvaraj, Pramod Sukumaran, Saobo Lei, Lutz Birnbaumer, Brij B Singh
Loss of dopaminergic (DA) neurons leads to Parkinson's disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood. We demonstrate that TRPC1 regulates the L-type Ca(2+) channel that contributes to the rhythmic activity of adult DA neurons in the substantia nigra region. Store depletion that activates TRPC1, via STIM1, inhibits the frequency and amplitude of the rhythmic activity in DA neurons of wild-type, but not in TRPC1(-/-), mice. Similarly, TRPC1(-/-) substantia nigra neurons showed increased L-type Ca(2+) currents, decreased stimulation-dependent STIM1-Cav1...
March 22, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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