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Balance and parkinson's disease

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https://www.readbyqxmd.com/read/28350890/quantification-of-motor-network-dynamics-in-parkinson-s-disease-by-means-of-landscape-and-flux-theory
#1
Han Yan, Jin Wang
The basal ganglia neural circuit plays an important role in motor control. Despite the significant efforts, the understanding of the principles and underlying mechanisms of this modulatory circuit and the emergence of abnormal synchronized oscillations in movement disorders is still challenging. Dopamine loss has been proved to be responsible for Parkinson's disease. We quantitatively described the dynamics of the basal ganglia-thalamo-cortical circuit in Parkinson's disease in terms of the emergence of both abnormal firing rates and firing patterns in the circuit...
2017: PloS One
https://www.readbyqxmd.com/read/28331638/effect-on-gait-speed-balance-motor-symptom-rating-and-quality-of-life-in-those-with-stage-i-parkinson-s-disease-utilizing-lsvt-big%C3%A2
#2
Beth Millage, Erin Vesey, Marsha Finkelstein, Mattie Anheluk
Individuals with Parkinson's Disease (PD) are often not referred to Physical Therapy (PT) until there are issues with mobility in later Hoehn and Yahr Stages. There have been no studies outlining the benefits of PT intervention in Stage I only. For persons with PD, deficits in motor function increase over time due to destruction of dopamine-producing cells. LSVT BIG, an exercise program for PD, has been shown to be effective in improving mobility. The purpose of this study was to assess participants functional improvement at a level of minimal clinically important difference (MCID) in one of four outcome measures: Gait Speed, Berg Balance Assessment, Functional Gait Assessment, and Unified Parkinson's Disease Rating Scale Motor Section...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28286168/predcar-site-carbonylation-sites-prediction-in-proteins-using-support-vector-machine-with-resolving-data-imbalanced-issue
#3
Md Al Mehedi Hasan, Jinyan Li, Shamim Ahmad, Md Khademul Islam Molla
The carbonylation is found as an irreversible post-translational modification and considered a biomarker of oxidative stress. It plays major role not only in orchestrating various biological processes but also associated with some diseases such as Alzheimer's disease, diabetes, and Parkinson's disease. However, since the experimental technologies are costly and time-consuming to detect the carbonylation sites in proteins, an accurate computational method for predicting carbonylation sites is an urgent issue which can be useful for drug development...
March 9, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28285031/evolution-and-complications-after-surgery-for-spine-deformation-in-patients-with-parkinson-s-disease
#4
Bouyer Benjamin, Scemama Caroline, P Roussouly, F Laouissat, I Obeid, L Boissière, F-H Parent, S Schuller, J-P Steib, H Pascal-Moussellard, P Guigui, Wolff Stéphane, Riouallon Guillaume
INTRODUCTION: Surgical treatment of spinal deformity is high risk in patients suffering from Parkinson's disease (PD). Several series have already reported a high rate of complications. However, none of these studies included more than 40 patients and none of the risk factors of complications were described. The aim of this study was to describe the rate and risk factors of revision surgery as well as the clinical outcome at the last visit in a large multicenter study of PD patients operated for spinal deformities...
March 8, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28281005/a-clinical-study-of-the-coronal-plane-deformity-in-parkinson-disease
#5
Xiaoyun Ye, Danning Lou, Xueping Ding, Chaoyan Xie, Jixiang Gao, Yuting Lou, Zhidong Cen, Yuxiang Xiao, Qianzhuang Miao, Fei Xie, Xiaosheng Zheng, Jianxin Wu, Fangcai Li, Wei Luo
BACKGROUND: Postural deformities in the coronal plane were frequent and disabling complications of PD, which reduces the quality of life of patients. This study aimed to garner greater attention to the Parkinson disease (PD)-related postural trunk deviations in the coronal plane by exploring a method for diagnosis because of the lack of any uniform diagnostic criteria and epidemiological studies. It also aimed to provide correlation data in the Chinese PD patients. METHODS: In this cross-sectional study, 503 consecutive outpatients with PD were enrolled who underwent standardized clinical evaluation...
March 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28275542/parkinson-s-disease-diffusion-mri-is-not-affected-by-acute-antiparkinsonian-medication
#6
Jae Woo Chung, Roxana G Burciu, Edward Ofori, Priyank Shukla, Michael S Okun, Christopher W Hess, David E Vaillancourt
OBJECTIVE: A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. METHODS: Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45 min after their usual dose of antiparkinsonian medication...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28274814/the-role-of-aquaporin-4-in-synaptic-plasticity-memory-and-disease
#7
REVIEW
Jacqueline A Hubbard, Jenny I Szu, Devin K Binder
Since the discovery of aquaporins, it has become clear that the various mammalian aquaporins play critical physiological roles in water and ion balance in multiple tissues. Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS, brain and spinal cord), has been shown to mediate CNS water homeostasis. In this review, we summarize new and exciting studies indicating that AQP4 also plays critical and unanticipated roles in synaptic plasticity and memory formation. Next, we consider the role of AQP4 in Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), neuromyelitis optica (NMO), epilepsy, traumatic brain injury (TBI), and stroke...
March 6, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28270047/instruction-prioritization-in-task-based-balance-training-for-individuals-with-idiopathic-parkinson-s-disease
#8
Vaithiamanithi Perumal, Ganeswara Rao Melam, Adel A Alhusaini, Syamala Buragadda, Neha Sharma
The objective of the study was to evaluate the effect of prioritization of instruction in balance training for individuals with Parkinson's disease (PD). Thirty-six participants were evaluated before and after the training using the Berg Balance Scale, Dynamic Gait Index, and Geriatric Depression Scale. Results show that dual task training with variable priority instruction is as effective as single task training in improving the balance performance of individuals with idiopathic PD.
March 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28268966/attractor-shape-descriptors-for-balance-impairment-assessment-in-parkinson-s-disease
#9
Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga
In this paper, we propose a computational framework using high-dimensional shape descriptors of reconstructed attractors of center-of-pressure (CoP) tracings collected from subjects with Parkinson's disease while performing dynamical posture shifts, to quantitatively assess balance impairment. Using a dataset collected from 60 subjects, we demonstrated that the proposed method outperforms traditional methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263252/flexed-truncal-posture-in-parkinson-disease-measurement-reliability-and-relationship-with-physical-and-cognitive-impairments-mobility-and-balance
#10
Aimi L Forsyth, Serene S Paul, Natalie E Allen, Catherine Sherrington, Victor S C Fung, Colleen G Canning
BACKGROUND AND PURPOSE: Flexed truncal posture is common in people with Parkinson disease (PD); however, little is known about the mechanisms responsible or its effect on physical performance. This cross-sectional study aimed to establish the reliability of a truncal posture measurement and explore relationships between PD impairments and truncal posture, as well as truncal posture and balance and mobility. METHODS: A total of 82 people with PD participated. Truncal posture was measured in standing as the distance between vertebra C7 and a wall...
April 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28258168/inhibition-of-l-type-ca-2-channels-by-trpc1-stim1-complex-is-essential-for-the-protection-of-dopaminergic-neurons
#11
Yuyang Sun, Haopeng Zhang, Senthil Selvaraj, Pramod Sukumaran, Saobo Lei, Lutz Birnbaumer, Brij B Singh
Loss of dopaminergic (DA) neurons leads to Parkinson's disease, however, the mechanism(s) for the vulnerability of DA neurons is not fully understood. We demonstrate that TRPC1 regulates the L-type Ca(2+) channel that contributes to the rhythmic activity of adult DA neurons in the substantia nigra (SN) region. Store-depletion that activates TRPC1, via STIM1, inhibits the frequency and amplitude of the rhythmic activity in DA neurons of wild-type, but not in TRPC1(-/-) mice. Similarly, TRPC1(-/-) SN neurons showed increased L-type Ca(2+) currents, decreased stimulation-dependent STIM1-Cav1...
March 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28254636/land-plus-aquatic-therapy-versus-land-based-rehabilitation-alone-for-the-treatment-of-balance-dysfunction-in-parkinson-s-disease-a-randomized-controlled-study-with-6-month-follow-up
#12
Grazia Palamara, Francesco Gotti, Roberto Maestri, Rossana Bera, Roberto Gargantini, Fabiola Bossio, Ilaria Zivi, Daniele Volpe, Davide Ferrazzoli, Giuseppe Frazzitta
OBJECTIVES: To assess whether a specific land-based physical intervention with the inclusion of aquatic therapy is more effective than land-based rehabilitation alone for the treatment of balance dysfunction in patients with Parkinson's disease (PD). To test the effect of these rehabilitative approaches after a 6-month follow-up period. DESIGN: Randomized controlled study with 6-month follow-up. SETTING: Department of Parkinson's Disease and Brain Injury Rehabilitation of the 'Moriggia-Pelascini' Hospital - Gravedona ed Uniti (CO, Italy)...
February 27, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28251677/mitochondrial-dna-and-primary-mitochondrial-dysfunction-in-parkinson-s-disease
#13
REVIEW
Maria Pia Giannoccaro, Chiara La Morgia, Giovanni Rizzo, Valerio Carelli
In 1979, it was observed that parkinsonism could be induced by a toxin inhibiting mitochondrial respiratory complex I. This initiated the long-standing hypothesis that mitochondrial dysfunction may play a key role in the pathogenesis of Parkinson's disease (PD). This hypothesis evolved, with accumulating evidence pointing to complex I dysfunction, which could be caused by environmental or genetic factors. Attention was focused on the mitochondrial DNA, considering the occurrence of mutations, polymorphic haplogroup-specific variants, and defective mitochondrial DNA maintenance with the accumulation of multiple deletions and a reduction of copy number...
March 2, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28244545/the-effect-of-balance-training-on-postural-control-in-patients-with-parkinson-s-disease-using-a-virtual-rehabilitation-system
#14
Sergio Albiol-Pérez, José-Antonio Gil-Gómez, María-Teresa Muñoz-Tomás, Hermenegildo Gil-Gómez, Raquel Vial-Escolano, José-Antonio Lozano-Quilis
OBJECTIVES: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor clinical alterations among others. Postural problems have serious consequences for patients, not only limiting their daily life but also increasing some risks, like the risk of fall. Inadequate postural control and postural instability is a major problem in PD patients. A Virtual Motor Rehabilitation System (VMR) has been tested in patients with PD in the intervention period. Our purpose was to analyze the evolution of the spatial postural control during the intervention period, to see if there are any changes caused precisely by this intervention...
February 28, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28243821/the-impact-of-short-and-long-term-exercise-on-the-expression-of-arc-and-ampars-during-evolution-of-the-6-hydroxy-dopamine-animal-model-of-parkinson-s-disease
#15
P C Garcia, C C Real, L R Britto
The loss of nigral dopaminergic neurons typical in Parkinson's disease (PD) is responsible for hyperexcitability of medium spiny neurons resulting in abnormal corticostriatal glutamatergic synaptic drive. Considering the neuroprotective effect of exercise, the changes promoted by exercise on AMPA-type glutamate receptors (AMPARs), and the role of activity-regulated cytoskeleton-associated protein (Arc) in the AMPARs trafficking, we studied the impact of short and long-term treadmill exercise during evolution of the unilateral 6-hydroxy-dopamine (6-OHDA) animal model of PD...
April 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28242732/inhibitory-dysfunction-contributes-to-some-of-the-motor-and-non-motor-symptoms-of-movement-disorders-and-psychiatric-disorders
#16
REVIEW
Marjan Jahanshahi, John C Rothwell
Recently, it has been proposed that similar to goal-directed and habitual action mediated by the fronto-striatal circuits, the fronto-striato-subthalamic-pallidal-thalamo-cortical network may also mediate goal-directed and habitual (automatic) inhibition in both the motor and non-motor domains. Within this framework, some of the clinical manifestations of Parkinson's disease, dystonia, Tourette syndrome and obsessive-compulsive disorder can be considered to represent an imbalance between goal-directed and habitual action and inhibition...
April 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28238838/polyphenols-in-combination-with-%C3%AE-cyclodextrin-can-inhibit-and-disaggregate-%C3%AE-synuclein-amyloids-under-cell-mimicking-conditions-a-promising-therapeutic-alternative
#17
Saurabh Gautam, Sandip Karmakar, Radhika Batra, Pankaj Sharma, Prashant Pradhan, Jasdeep Singh, Bishwajit Kundu, Pramit K Chowdhury
Parkinson's disease is characterized by the presence of insoluble and neurotoxic aggregates (amyloid fibrils) of an intrinsically disordered protein α-synuclein. In this study we have examined the effects of four naturally occurring polyphenols in combination with β-cyclodextrin (β-CD) on the aggregation of α-synuclein in the presence of macromolecular crowding agents. Our results reveal that even at sub-stoichiometric concentrations of the individual components, the polyphenol-β-CD combination(s) not only inhibited the aggregation of the proteins but was also effective in disaggregating preformed fibrils...
February 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28229895/impulse-control-disorders-and-levodopa-induced-dyskinesias-in-parkinson-s-disease-an-update
#18
REVIEW
Valerie Voon, T Celeste Napier, Michael J Frank, Veronique Sgambato-Faure, Anthony A Grace, Maria Rodriguez-Oroz, Jose Obeso, Erwan Bezard, Pierre-Olivier Fernagut
Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists...
March 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28227173/attractor-shape-descriptors-for-balance-impairment-assessment-in-parkinson-s-disease
#19
Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga, Anirudh Som, Narayanan Krishnamurthi, Vinay Venkataraman, Pavan Turaga, Narayanan Krishnamurthi, Anirudh Som, Pavan Turaga
In this paper, we propose a computational framework using high-dimensional shape descriptors of reconstructed attractors of center-of-pressure (CoP) tracings collected from subjects with Parkinson's disease while performing dynamical posture shifts, to quantitatively assess balance impairment. Using a dataset collected from 60 subjects, we demonstrated that the proposed method outperforms traditional methods, such as dynamical shift indices and use of chaotic invariants, in assessment of balance impairment.
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225753/complement-drives-glucosylceramide-accumulation-and-tissue-inflammation-in-gaucher-disease
#20
Manoj K Pandey, Thomas A Burrow, Reena Rani, Lisa J Martin, David Witte, Kenneth D Setchell, Mary A Mckay, Albert F Magnusen, Wujuan Zhang, Benjamin Liou, Jörg Köhl, Gregory A Grabowski
Gaucher disease is caused by mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase (GCase). GBA1 mutations drive extensive accumulation of glucosylceramide (GC) in multiple innate and adaptive immune cells in the spleen, liver, lung and bone marrow, often leading to chronic inflammation. The mechanisms that connect excess GC to tissue inflammation remain unknown. Here we show that activation of complement C5a and C5a receptor 1 (C5aR1) controls GC accumulation and the inflammatory response in experimental and clinical Gaucher disease...
February 22, 2017: Nature
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