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https://www.readbyqxmd.com/read/28214984/dl-3-n-butylphthalide-nbp-provides-neuroprotection-in-the-mice-models-after-traumatic-brain-injury-via-nrf2-are-signaling-pathway
#1
Zhengwei Liu, Handong Wang, Xiaofeng Shi, Liwen Li, Mengliang Zhou, Hui Ding, Youqing Yang, Xiang Li, Ke Ding
The present study was aimed to evaluate the neuroprotective effects of NBP in the mice models of TBI, as well as the possible role of Nrf2-ARE pathways in the assumptive neuroprotection. In mice,a modified Marmarou's weight-drop model was employed to induce TBI. ICR mice were randomly assigned to four experimental groups: sham, TBI, TBI+vehicle(V) and TBI+NBP. NBP (100 mg/kg) was administered via an intraperitoneal (i.p.) injection at 1 h following TBI. The administration of NBP significantly ameliorated the effects of the brain injury, including neurological deficits, brain water content, and cortical neuronal apoptosis...
February 18, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28214972/avocado-oil-induces-long-term-alleviation-of-oxidative-damage-in-kidney-mitochondria-from-type-2-diabetic-rats-by-improving-glutathione-status
#2
Omar Ortiz-Avila, María Del Consuelo Figueroa-García, Claudia Isabel García-Berumen, Elizabeth Calderón-Cortés, Jorge A Mejía-Barajas, Alain R Rodriguez-Orozco, Ricardo Mejía-Zepeda, Alfredo Saavedra-Molina, Christian Cortés-Rojo
Hyperglycemia and mitochondrial ROS overproduction have been identified as key factors involved in the development of diabetic nephropathy. This has encouraged the search for strategies decreasing glucose levels and long-term improvement of redox status of glutathione, the main antioxidant counteracting mitochondrial damage. Previously, we have shown that avocado oil improves redox status of glutathione in liver and brain mitochondria from streptozotocin-induced diabetic rats; however, the long-term effects of avocado oil and its hypoglycemic effect cannot be evaluated because this model displays low survival and insulin depletion...
February 18, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/28214935/promotive-role-of-5-aminolevulinic-acid-on-chromium-induced-morphological-photosynthetic-and-oxidative-changes-in-cauliflower-brassica-oleracea-botrytis-l
#3
Rehan Ahmad, Shafaqat Ali, Fakhir Hannan, Muhammad Rizwan, Muhammad Iqbal, Zaidul Hassan, Nudrat Aisha Akram, Saliha Maqbool, Farhat Abbas
Chromium (Cr) is among the most toxic pollutants in the environment that adversely affect the living organisms and physiological processes in different plants. The present study investigated the effect of 15 mg L(-1) of 5-aminolevulinic acid (ALA) on morpho-physiological attributes of cauliflower (Brassica oleracea botrytis L.) under different Cr concentrations (0, 10, 100, and 200 μM) in the growth medium. The results showed that Cr stress decreased the growth, biomass, photosynthetic, and gas exchange parameters...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214934/the-effect-of-low-molecular-weight-organic-acids-on-copper-toxicity-in-e-fetida-in-an-acute-exposure-system
#4
Chuifan Zhou, Meiying Huang, Jiaoda Yu, Ying Li, Aiqin Liu
In the present study, the effects of low-molecular-weight organic acids (OAs) on the toxicity of copper (Cu) to the earthworm Eisenia fetida (E. fetida) were investigated in a simulated soil solution. We exposed E. fetida to soil solution containing Cu and a variety of OAs (acetic acid, oxalic acid, citric acid, and EDTA). We found that the addition of OAs reduced the toxicity of Cu to E. fetida, where the reduction was strongest in EDTA and weakest in acetic acid. These compounds decreased the mortality rate of E...
February 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28214728/lipid-signalling-mediated-by-pld-pa-modulates-proline-and-h2o2-levels-in-barley-seedlings-exposed-to-short-and-long-term-chilling-stress
#5
Micaela Peppino Margutti, Matias Reyna, María Verónica Meringer, Graciela E Racagni, Ana Laura Villasuso
Phospholipase D (PLD) hydrolyses phospholipids to yield phosphatidic acid (PA) and a head group, and is involved in responses to a variety of environmental stresses, including chilling and freezing stress. Barley responses to chilling stress (induced by incubating seedlings at 4 °C) are dynamic and the duration of stress, either short (0-180 min) or long-term (24-36 h) had a significant impact on the response. We investigated the roles of PLD/PA in responses of barley (Hordeum vulgare) seedlings to short and long-term chilling stress, based on regulation of proline and reactive oxygen species (ROS) levels...
February 10, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28214706/influence-of-oxygen-partial-pressure-on-the-characteristics-of-human-hepatocarcinoma-cells
#6
Jenifer Trepiana, Susana Meijide, Rosaura Navarro, M Luisa Hernández, José Ignacio Ruiz-Sanz, M Begoña Ruiz-Larrea
Most of the in vitro studies using liver cell lines have been performed under atmospheric oxygen partial pressure (21% O2). However, the oxygen concentrations in the liver and cancer cells are far from this value. In the present study, we have evaluated the influence of oxygen on 1) the tumor cell lines features (growth, steady-state ROS levels, GSH content, activities of antioxidant enzymes, p66 Shc and SOD expressions, metalloproteinases secretion, migration, invasion, and adhesion) of human hepatocellular carcinoma cell lines, and b) the response of the cells to an oxidant stimulus (aqueous leaf extract of the V...
February 13, 2017: Redox Biology
https://www.readbyqxmd.com/read/28214685/role-of-laxative-and-antioxidant-properties-of-malva-sylvestris-leaves-in-constipation-treatment
#7
Mohamed-Amine Jabri, Dalanda Wannes, Najla Hajji, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
INTRODUCTION: Mallaw (Malva sylvestris L.) is a medicinal plant who is traditionally being used as an antiulcer, laxative and anti-hemorrhoid, besides of its culinary use as a food in Tunisian cuisine. The present study was carried out to evaluate the protective effect of Malva sylvestris aqueous extract (MSAE) on constipation- induced by loperamide in male Wistar rats. METHODS: Rats were divided into six groups of six animals each: Control, Loperamide (LOP), LOP+ yohimbine (2mg/kg b...
February 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28214625/curcumin-functionalized-silk-biomaterials-for-anti-aging-utility
#8
Lei Yang, Zhaozhu Zheng, Cheng Qian, Jianbing Wu, Yawen Liu, Shaozhe Guo, Gang Li, Meng Liu, Xiaoqin Wang, David L Kaplan
Curcumin is a natural antioxidant that is isolated from turmeric (Curcuma longa) and exhibits strong free radical scavenging activity, thus functional for anti-aging. However, poor stability and low solubility of curcumin in aqueous conditions limit its biomedical applications. Previous studies have shown that the anti-oxidation activity of curcumin embedded in silk fibroin films could be well preserved, resulting in the promoted adipogenesis from human mesenchymal stem cells (hMSCs) cultured on the surface of the films...
February 2, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28214600/intestine-oxidative-stress-and-immune-response-to-sulfide-stress-in-pacific-white-shrimp-litopenaeus-vannamei
#9
Yafei Duan, Hongbiao Dong, Yun Wang, Hua Li, Qingsong Liu, Yue Zhang, Jiasong Zhang
The effects of sulfide stress on oxidative stress and immune response in intestine of Pacific white shrimp Litopenaeus vannamei were evaluated in the present study. Oxidative stress parameters, immune enzymes activity and immune gene mRNA expression level were detected in intestine of L. vannamei after the exposure of 5.0 mg/L sulfide stress 72 h. The duration of sulfide stress influenced the shrimp survival, and the cumulative mortality rate was 30.0% and 33.3% at 48 h and 72 h respectively. HE staining showed that sulfide stress caused the intestine tissue damage symptoms...
February 15, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28214539/lumbee-traditional-medicine-neuroprotective-activities-of-medicinal-plants-used-to-treat-parkinson-s-disease-related-symptoms
#10
Aurélie de Rus Jacquet, Michael Timmers, Sin Ying Ma, Andrew Thieme, George P McCabe, Jay Hansford C Vest, Mary Ann Lila, Jean-Christophe Rochet
ETHNOPHARMACOLOGICAL RELEVANCE: Parkinson's disease (PD) is a neurodegenerative disorder characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta and the presence in surviving neurons of Lewy body inclusions enriched with aggregated forms of the presynaptic protein α-synuclein (aSyn). Although current therapies provide temporary symptomatic relief, they do not slow the underlying neurodegeneration in the midbrain. In this study, we analyzed contemporary herbal medicinal practices used by members of the Lumbee tribe to treat PD-related symptoms, in an effort to identify safe and effective herbal medicines to treat PD...
February 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28214348/organo-protective-and-antioxidant-properties-of-leaf-extracts-of-syzygium-guineense-var-macrocarpum-against-ferric-nitriloacetate-induced-stress-of-wistar-rats
#11
Francine Tankeu Nzufo, Constant Anatole Pieme, Jacques Romain Njimou, Prosper Cabral Biapa Nya, Bruno Moukette Moukette, Bravi Marco, Chianese Angelo, Ngogang Jeanne Yonkeu
Background The present study focused on the antioxidant, phenolic profile and free radical scavenging-mediated protective effect of leaves extracts of Syzygium guineense var. macrocarpum against ferric nitriloacetate-induced stress in the liver, heart, kidney and brain tissues of Wistar rats homogenates. Methods Spectrophotometric standardized methods were used to determine the free radical scavenging potential, antioxidant and protective properties of plant extracts on rat homogenates. Results All the extracts showed a concentration-dependent free radical quenching potential, and the ability to protect all the tested organs by inhibiting the lipid peroxidation and potentiating or restoring the activity of enzymatic and non enzymatic markers...
February 16, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28214344/neferine-potentiates-the-antitumor-effect-of-cisplatin-in-human-lung-adenocarcinoma-cells-via-a-mitochondria-mediated-apoptosis-pathway
#12
Kalai Selvi Sivalingam, Poornima Paramasivan, Ching Feng Weng, Viswanadha Vijaya Padma
Cisplatin is one of the most potent chemotherapeutic agents for the treatment of many types of solid tumors but its efficacy is often limited by the development of resistance and dose limiting toxicity. Neferine is an alkaloid isolated from seed embryo of Nelumbo nucifera, it has recently been shown to have anticancer effects in various human cancer cell lines. The present investigation is designed to study the chemosensitizing ability of neferine with cisplatin in A549 cells. Neferine potentiates the cisplatin induced apoptosis through the exploration of characteristic apoptotic morphological changes, induced sub-G0/G1 cell cycle arrest, ROS hypergeneration, significant loss of cellular antioxidant enzymes as well as loss of mitochondrial membrane potential (ΔΨM)...
February 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28214329/-p-clphse-2-reduces-hepatotoxicity-induced-by-monosodium-glutamate-by-improving-mitochondrial-function-in-rats
#13
Caroline B Quines, Pietro M Chagas, Diane Hartmann, Nélson R Carvalho, Félix A Soares, Cristina W Nogueira
It is has been demonstrated that mitochondrial dysfunction, oxidative stress and chronic inflammatory process are associated with progress of morbid obesity in human patients. For this reason, the searching for safe and effective antiobesity drugs has been the subject of intense research. In this context, the organic selenium compounds have attracted much attention due to their pharmacological properties, such as antihyperglycemic, antioxidant and anti-inflammatory. The aim of this study was to evaluate the hepatoprotective action of p-chloro-diphenyl diselenide (p-ClPhSe)2 , an organic selenium compound, in a model of obesity induced by monosodium glutamate (MSG) administration in rats...
February 18, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28214191/potential-of-different-am-fungi-native-from-as-contaminated-and-uncontaminated-soils-for-supporting-leucaena-leucocephala-growth-in-as-contaminated-soil
#14
Jerusa Schneider, Jochen Bundschuh, Wesley de Melo Rangel, Luiz Roberto Guimarães Guilherme
Arbuscular mycorrhizal (AM) fungi inoculation is considered a potential biotechnological tool for an eco-friendly remediation of hazardous contaminants. However, the mechanisms explaining how AM fungi attenuate the phytotoxicity of metal(oid)s, in particular arsenic (As), are still not fully understood. The influence of As on plant growth and the antioxidant system was studied in Leucaena leucocephala plants inoculated with different isolates of AM fungi and exposed to increasing concentrations of As (0, 35, and 75 mg dm(-3)) in a Typic Quartzipsamment soil...
February 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28213900/c-h-direct-arylated-6h-indolo-2-3-b-quinoxaline-derivative-as-thickness-dependent-hole-injection-layer
#15
Dai Dong, Da Fang, Hairong Li, Caixia Zhu, Xianghua Zhao, Jiewei Li, Lingzhi Jin, Linghai Xie, Lin Chen, Jianfeng Zhao, Hongmei Zhang, Wei Huang
A novel perfluoro-1,4-phenylenyl 6H-indolo[2,3-b]quinoxaline derivative (TFBIQ) was designed and synthesized via C-H direct arylation. The opto-electrical properties of the obtained TFBIQ were fully characterized by UV-vis and photoluminescence, cyclic voltammetry, film morphology and Alq3-based green organic light emitting diodes (OLEDs). Device A using 0.5 nm thick TFBIQ as the interfacial modification layer exhibits the best five advantages of device performance including the lowest minimum turn-on voltage (Von) as low as 3...
February 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28213772/the-effect-of-purinergic-signaling-via-the-p2y11-receptor-on-vascular-function-in-a-rat-model-of-acute-inflammation
#16
Maria D Dănilă, Andreea Privistirescu, Oana M Duicu, Corina D Rațiu, Denis Angoulvant, Danina M Muntean, Adrian Sturza
There is a growing body of evidence pointing to the role of purinergic signaling in the development and progression of various conditions that have inflammation as a common pathogenetic denominator. The aim of the present study was to assess the involvement of P2Y11 purinergic receptors in the regulation of vascular function in aortic segments obtained using an experimental model of acute inflammation, the lipopolysaccharide (LPS, 8 mg/kg, i.p)-treated rats. Twelve hours after LPS administration, thoracic aortas were isolated and used for studies of vascular reactivity in the organ bath and for the measurement of reactive oxygen species (ROS) generation, respectively...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28213388/effects-of-dopamine-donor-pretreatment-on-graft-survival-after-kidney-transplantation-a-randomized-trial
#17
Peter Schnuelle, Wilhelm H Schmitt, Christel Weiss, Antje Habicht, Lutz Renders, Martin Zeier, Felix Drüschler, Katharina Heller, Przemyslaw Pisarski, Bernhard Banas, Bernhard K Krämer, Matthias Jung, Kai Lopau, Christoph J Olbricht, Horst Weihprecht, Peter Schenker, Johan W De Fijter, Benito A Yard, Urs Benck
BACKGROUND AND OBJECTIVES: Donor dopamine improves initial graft function after kidney transplantation due to antioxidant properties. We investigated if a 4 µg/kg per minute continuous dopamine infusion administered after brain-death confirmation affects long-term graft survival and examined the exposure-response relationship with treatment duration. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Five-year follow-up of 487 renal transplant patients from 60 European centers who had participated in the randomized, multicenter trial of dopamine donor pretreatment between 2004 and 2007 (ClinicalTrials...
February 17, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28213332/shear-stress-enhances-ca-2-sparks-through-nox2-dependent-mitochondrial-reactive-oxygen-species-generation-in-rat-ventricular-myocytes
#18
Joon-Chul Kim, Jun Wang, Min-Jeong Son, Sun-Hee Woo
Shear stress enhances diastolic and systolic Ca(2+) concentration in ventricular myocytes. Here, using confocal Ca(2+) imaging in rat ventricular myocytes, we assessed the effects of shear stress (~16dyn/cm(2)) on the frequency of spontaneous Ca(2+) sparks and explored the mechanism underlying shear-mediated Ca(2+) spark regulation. The frequency of Ca(2+) sparks was immediately increased by shear stress (by ~80%), and increased further (by ~150%) during prolonged exposure (20s). The 2-D size and duration of individual sparks were increased by shear stimulation...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28213323/growth-inhibition-and-efficiency-of-the-antioxidant-system-in-spring-barley-and-common-radish-grown-on-soil-polluted-ionic-liquids-with-iodide-anions
#19
Robert Biczak, Martyna Śnioszek, Arkadiusz Telesiński, Barbara Pawłowska
Ionic liquids (ILs) constitute a huge group of substances that are increasingly common in the commercial use. This situation may lead to the contamination of the soil environment which being the basic of plants vegetation. This paper presents the effect of four ILs with I(-) anion on the growth and development of spring barley (Hordeum vulgare) and common radish (Raphanus sativus L. subvar. radicula Pers) and changes in metabolism of the plants. Seedlings of spring barley and common radish cultivated on soil with increasing ILs concentration exhibited typical phytotoxicity symptoms...
February 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28213291/hepatoprotective-effect-of-2-o-galloylhyperin-against-oxidative-stress-induced-liver-damage-through-induction-of-nrf2-are-mediated-antioxidant-pathway
#20
Peng Wang, Yi-Meng Gao, Xing Sun, Na Guo, Ji Li, Wei Wang, Li-Ping Yao, Yu-Jie Fu
2'-O-galloylhyperin (2'-O-GH), an active compound isolated from Pyrola calliantha, possesses remarkable antioxidant activity. The aims of this study were to investigate the hepatoprotective effect of 2'-O-GH against oxidative stress and elucidate the underlying mechanistic signaling pathways in HepG2 cells as well as in an animal model. Results showed that 2'-O-GH significantly inhibited hydrogen peroxide (H2O2)-induced HepG2 cell death in a dose dependent manner. The mitogen-activated protein kinase activation, ROS production, mitochondrial membrane potential, intracellular calcium level and subsequent apoptotic protein activation in H2O2-stimulated HepG2 cells were remarkably inhibited by 2'-O-GH...
February 14, 2017: Food and Chemical Toxicology
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