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https://www.readbyqxmd.com/read/29169189/lifelong-voluntary-exercise-modulates-age-related-changes-in-oxidative-stress
#1
Mohamed Amine Bouzid, Edith Filaire, Régis Matran, Sophie Robin, Claudine Fabre
The hypothesis that aging and regular physical activity could influence oxidative stress has been studied by comparing antioxidant activities (superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GR), ascorbic acid and α-Tocopherol) and malondialdehyde level (MDA) in four groups: young sedentary (n=15; age: 20.3±2.8 years; YS), young active (n=16; age: 21.4±1.9 years; YA), old sedentary (n=15; age: 65.1±3.5 years; OS) and old active (n=17; age: 67.2±4.8 years; OA). Antioxidant activities and MDA level were assessed at rest and after an incremental exercise...
November 23, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29169180/mitochondria-targeted-antioxidant-mito-tempo-protects-against-aldosterone-induced-renal-injury-in-vivo
#2
Wei Ding, Tingyan Liu, Xiao Bi, Zhiling Zhang
BACKGROUND/AIMS: Growing evidence suggests mitochondrial dysfunction (MtD) and the Nlrp3 inflammasome play critical roles in chronic kidney disease (CKD) progression. We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome. Here we aimed to determine whether a mitochondria-targeted antioxidant (Mito-Tempo) could prevent Aldo-induced kidney damage in vivo...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169174/melatonin-induced-changes-in-cytosolic-calcium-might-be-responsible-for-apoptosis-induction-in-tumour-cells
#3
Barbora Chovancova, Sona Hudecova, Lubomira Lencesova, Petr Babula, Ingeborg Rezuchova, Adela Penesova, Marian Grman, Roman Moravcik, Michal Zeman, Olga Krizanova
BACKGROUND/AIMS: Melatonin is a hormone transferring information about duration of darkness to the organism and is known to modulate several signaling pathways in the cells, e.g. generation of endoplasmic reticulum stress, oxidative status of the cells, etc. Melatonin has been shown to exert antiproliferative and cytotoxic effects on various human cancers. We proposed that this hormone can differently affect tumour cells and healthy cells. METHODS: We compared the effect of 24 h melatonin treatment on calcium transport (by fluorescent probes FLUO-3AM and Rhod-5N), ER stress (determined as changes in the expression of CHOP, XBP1 and fluorescently, using Thioflavin T), ROS formation (by CellROX® Green/Orange Reagent) and apoptosis induction (by Annexin-V-FLUOS/propidiumiodide) in two tumour cell lines - ovarian cancer cell line A2780 and stable cell line DLD1 derived from colorectal carcinoma, with non-tumour endothelial cell line EA...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169133/alterations-of-mitochondrial-antioxidant-indexes-and-apoptosis-in-duck-livers-caused-by-molybdenum-or-and-cadmium
#4
Xueyan Dai, Chenghong Xing, Huabin Cao, Junrong Luo, Tiancheng Wang, Ping Liu, Xiaoquan Guo, Guoliang Hu, Caiying Zhang
Cadmium (Cd) and high Molybdenum (Mo) can lead to adverse reactions on animals, but the co-induced toxicity of Mo and Cd to liver in ducks was not well understood. To investigate the co-induced toxic effects of Mo combined with Cd on mitochondrial oxidative stress and apoptosis in duck livers. 240 healthy 11-day-old ducks were randomly divided into 6 groups (control, LMo group, HMo group, Cd group, LMoCd group and HMoCd group). After being treated for 30, 60, 90 and 120 days, liver mitochondrial antioxidant indexes, ceruloplasmin (CP), metallothionein (MT), Bak-1 and Caspase-3 genes mRNA expression levels, and ultrastructural changes were evaluated...
November 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/29169111/identification-of-phenolic-components-via-lc-ms-analysis-and-biological-activities-of-two-centaurea-species-c-drabifolia-subsp-drabifolia-and-c-lycopifolia
#5
Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Paraskev Nedialkov, Andrei Mocan, Ana Ćirić, Jasmina Glamočlija, Marina Soković, Abdurrahman Aktumsek, M Fawzi Mahomoodally
The Centaurea genus has great potential in traditional systems and has attracted much interest in the design of novel drug formulations. The present study was focused on the chemical fingerprints and biological properties of Centaurea drabifolia subsp. drabifolia and Centaurea lycopifolia extracts. Spectrophotometric and LC-MS techniques were used to establish the chemical profiles of the studied extracts. Enzyme inhibitory potential was assessed against key enzymes linked to global health problems, namely neurodegenerative diseases (acetylcholinesterase), pigmentation (tyrosinase), and diabetes (α-amylase and α-glucosidase)...
November 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169042/synthesis-of-aromatic-and-indole-alpha-glucosinolates
#6
Quan V Vo, Simone Rochfort, Pham C Nam, Tuan L Nguyen, Trung T Nguyen, Adam Mechler
Aromatic and indole glucosinolates are important members of the glucosinolate family of compounds du to their potential medicinal properties. They are known to exert antioxidant and anti-carcinogenic activity either by the natural products themselves, or their metabolic products including indole-3-carbinol and isothiocyanates. Natural glucosinolates are all β-glucosinolates; however, α-glucosinolates are also promising compounds for medicinal applications and hence have to be produced synthetically for any bio-activity studies...
November 20, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29169010/oxidative-stress-burden-inhibits-spermatogenesis-in-adult-male-rats-testosterone-protective-effect
#7
Samy Makary, Mohamed Abdo, Ereny Fekry
In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MTX has been shown to induce oxidative stress and exhibit antiproliferative effects in the testes. Adult male rats received oral saline gavage (control group with no treatment), the potential protective agents (LET, GSE, or Tp) alone, MTX alone, or a combination of one of the potential protective agents and MTX...
November 23, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29168872/organoselenium-compounds-as-mimics-of-selenoproteins-and-thiol-modifier-agents
#8
REVIEW
Nilda V Barbosa, Cristina W Nogueira, Pablo A Nogara, Andreza F de Bem, Michael Aschner, João B T Rocha
Selenium is an essential trace element for animals and its role in the chemistry of life relies on a unique functional group: the selenol (-SeH) group. The selenol group participates in critical redox reactions. The antioxidant enzymes glutathione peroxidase (GPx) and thioredoxin reductase (TrxR) exemplify important selenoproteins. The selenol group shares several chemical properties with the thiol group (-SH), but it is much more reactive than the sulfur analogue. The substitution of S by Se has been exploited in organic synthesis for a long time, but in the last 4 decades the re-discovery of ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) and the demonstration that it has antioxidant and therapeutic properties has renovated interest in the field...
November 23, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29168867/the-protective-effect-of-phloretin-in-osteoarthritis-an-in-vitro-and-in-vivo-study
#9
Wenhao Zheng, Chunhui Chen, Chuanxu Zhang, Leyi Cai, Hua Chen
Osteoarthritis (OA) is a degenerative joint disease characterized by the degradation and inflammation of cartilage. Phloretin, a type of dihydrochalcone mainly found in apples and apple-derived products, has been reported to possess various potent biological effects such as antioxidant, anticancer, anti-inflammatory, and immunomodulatory. However, the anti-inflammatory effects of phloretin on OA have not been reported. This study was aimed at assessing the effects of phloretin on human OA chondrocytes. Human OA chondrocytes were pretreated with phloretin (10, 30, and 100 μM) for 2 h and subsequently stimulated with IL-1β for 24 h...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168866/chemical-composition-and-bioactive-properties-of-the-wild-mushroom-polyporus-squamosus-huds-fr-a-study-with-samples-from-romania
#10
Andrei Mocan, Ângela Fernandes, Lillian Barros, Gianina Crişan, Marija Smiljković, Marina Soković, Isabel C F R Ferreira
In Eastern Europe, wild mushrooms are widely collected in mountain areas and used for their medicinal properties or as healthy foods. This study aimed at determining the chemical composition (nutritional value, free sugars, organic acids, phenolic compounds, fatty acids and tocopherols) and bioactive properties (antioxidant, antimicrobial and antiquorum sensing) of wild Polyporus squamosus (Huds.) Fr from Romania. The results indicate that the fruiting bodies of P. squamosus are rich in carbohydrates (74.22 g per 100 g dw) and proteins (18...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168862/inhibition-of-advanced-glycation-endproducts-during-fish-sausage-preparation-by-transglutaminase-and-chitosan-oligosaccharides-induced-enzymatic-glycosylation
#11
Jing Wang, Long Zou, Fangzhou Yuan, Liangtao Lv, Shenglan Tian, Zhenxing Li, Hong Lin
Advanced glycation endproducts (AGEs) are the harmful products of non-enzymatic reactions in foods formed during the heating process. In order to reduce the content of AGEs in foods, the inhibitory effect of different proportions of transglutaminase (TGase) and chitosan oligosaccharides (COS) on the AGEs of seabream fish meat sausage was studied. The results indicated that the TGase/COS ratio of 1 : 1 could inhibit the formation of AGEs, showing especially a decreased N(ε)-carboxymethyl-lysine (CML) content and a twice higher inhibition rate (36...
November 23, 2017: Food & Function
https://www.readbyqxmd.com/read/29168797/role-of-vitamin-e-in-the-treatment-of-alzheimer-s-disease-evidence-from-animal-models
#12
REVIEW
Agnese Gugliandolo, Placido Bramanti, Emanuela Mazzon
Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of dementia. It is characterized by memory loss, and cognitive and behavioral decline. In particular, the hallmarks of the pathology are amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), formed by aggregated hyperphosphorylated tau protein. Oxidative stress plays a main role in AD, and it is involved in initiation and progression of AD. It is well known that Aβ induced oxidative stress, promoting reactive oxygen species (ROS) production and consequently lipid peroxidation, protein oxidation, tau hyperphosphorylation, results in toxic effects on synapses and neurons...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168781/structural-diversity-and-biological-activities-of-the-cyclodipeptides-from-fungi
#13
REVIEW
Xiaohan Wang, Yuying Li, Xuping Zhang, Daowan Lai, Ligang Zhou
Cyclodipeptides, called 2,5-diketopiperazines (2,5-DKPs), are obtained by the condensation of two amino acids. Fungi have been considered to be a rich source of novel and bioactive cyclodipeptides. This review highlights the occurrence, structures and biological activities of the fungal cyclodipeptides with the literature covered up to July 2017. A total of 635 fungal cyclodipeptides belonging to the groups of tryptophan-proline, tryptophan-tryptophan, tryptophan-Xaa, proline-Xaa, non-tryptophan-non-proline, and thio-analogs have been discussed and reviewed...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168774/carotenoids-from-marine-organisms-biological-functions-and-industrial-applications
#14
REVIEW
Christian Galasso, Cinzia Corinaldesi, Clementina Sansone
As is the case for terrestrial organisms, carotenoids represent the most common group of pigments in marine environments. They are generally biosynthesized by all autotrophic marine organisms, such as bacteria and archaea, algae and fungi. Some heterotrophic organisms also contain carotenoids probably accumulated from food or partly modified through metabolic reactions. These natural pigments are divided into two chemical classes: carotenes (such as lycopene and α- and β-carotene) that are composed of hydrogen and carbon; xanthophylls (such as astaxanthin, fucoxanthin and lutein), which are constituted by hydrogen, carbon and oxygen...
November 23, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29168734/impact-of-ohmic-assisted-decoction-on-bioactive-components-extracted-from-yacon-smallanthus-sonchifolius-poepp-leaves-comparison-with-conventional-decoction
#15
Forough Khajehei, Mehrdad Niakousari, Maral Seidi Damyeh, Nikolaus Merkt, Wilhelm Claupein, Simone Graeff-Hoenninger
Yacon (Smallanthus sonchifolius Poepp.) leaves are a potentially rich source of bioactive compounds, such as phenolic acids and flavonoids. In this study, the effect of the extraction method (ohmic-assisted decoction (OH-DE) and decoction (DE)), yacon cultivar (red and white), and leaf age (young and old) on the quality/quantity of extracted phytochemicals were investigated. Extraction yield, energy consumption, total phenolic content (TPC), total flavonoid content (TFC), ABTS and DPPH radical scavenging activity, and ferric reducing antioxidant power (FRAP) were determined...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168585/the-prognostic-impact-of-serum-bilirubin-in-stage-iv-colorectal-cancer-patients
#16
Lin Yang, Lu-Yao Ge, Ting Yu, Yan Liang, Ying Yin, Hong Chen
BACKGROUND: Bilirubin played a great role in antioxidation and anticancer and has been considered as a promising prognostic factor of non-liver disease-related death in various cancers. The aim of this study was to assess the prognostic value of pre-treatment serum bilirubin in stage IV CRC patients. METHODS: Serum bilirubin including TBIL, DBIL, and IBI which were tested at pre-treatment were investigated in 154 stage IV CRC patients in Zhongda Hospital, Nanjing, China, from July 2005 to July 2011...
November 23, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29168580/resveratrol-pterostilbene-and-dementia
#17
REVIEW
Klaus W Lange, Shiming Li
Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia...
November 23, 2017: BioFactors
https://www.readbyqxmd.com/read/29168405/acrylamide-attenuated-immune-tissues-function-via-induction-of-apoptosis-and-oxidative-stress-protection-by-l-carnitine
#18
E Zamani, M Shokrzadeh, A Ziar, S Abedian-Kenari, F Shaki
Acrylamide (ACR), with high prevalence in starchy food, has been associated with the development of several organ toxicities such as immunotoxicity. This study aimed to demonstrate the role of oxidative stress and apoptosis as the mechanisms involved in ACR-induced immunotoxicity in mice. Mice were randomly assigned to six groups and treated as follows: control (normal saline), cyclophosphamide (200 mg kg(-1)), ACR groups (12.5, 25 and 50mg kg(-1), orally), and l-carnitine (l-CAR; 100 mg kg(-1)) + ACR (50 mg kg(-1))...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29168398/paraoxonase-arylesterase-and-lactonase-activities-of-paraoxonase-1-pon1-in-obese-and-severely-obese-women
#19
Carlo Cervellati, Gloria Bonaccorsi, Alessandro Trentini, Giuseppe Valacchi, Juana M Sanz, Monica Squerzanti, Manuela Spagnolo, Leo Massari, Ilaria Crivellari, Pantaleo Greco, Roberta Parladori, Angelina Passaro, Giorgio Ricci
Obesity is independently associated with disturbances in lipid and lipoprotein metabolism, oxidative stress, and is a well-established independent risk factor for cardiovascular diseases (CVD). Human paraoxonase 1 (PON1) is a pleotropic high-density lipoprotein (HDL)-associated enzyme with antioxidant and anti-inflammatory proprieties that have been suggested to contribute to the athero-protective function of the lipoprotein. The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration...
November 23, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29168281/a-review-of-urban-impacts-on-avian-life-history-evolution-does-city-living-lead-to-slower-pace-of-life
#20
REVIEW
Tuul Sepp, Kevin J McGraw, Ants Kaasik, Mathieu Giraudeau
The concept of a pace-of-life syndrome describes inter- and intraspecific variation in several life-history traits along a slow-to-fast pace-of-life continuum, with long lifespans, low reproductive and metabolic rates, and elevated somatic defences at the slow end of the continuum and the opposite traits at the fast end. Pace-of-life can vary in relation to local environmental conditions (e.g. latitude, altitude), and here we propose that this variation may also occur along an anthropogenically modified environmental gradient...
November 23, 2017: Global Change Biology
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