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https://www.readbyqxmd.com/read/27915407/analysis-of-the-antioxidant-activity-of-4-5-chloro-2-hydroxyphenylamino-4-oxobut-2-enoic-acid-derivatives-using-quantum-chemistry-descriptors-and-molecular-docking
#1
Ahmed Taki Eddine Ardjani, Sidi Mohamed Mekelleche
In the present work, the molecular structure and the antioxidant activity of 4-(5-chloro-2-hydroxyphenylamino)-4-oxobut-2-enoic acid (A) and its derivatives (B-E) have been studied at the B3LYP/6-31++G(2d,2p) computational level. The obtained results indicate that the hydrogen atom transfer (HAT mechanism) is thermodynamically more favored in gas phase; whereas, the sequential proton loss-electron transfer (SPLET mechanism) is more preferred in polar solvents. The antioxidant activity of compounds A-E is also analyzed by the calculation of atomic spin densities, chemical hardnesses, dipole moments, and lipophilicity indexes...
December 2016: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/27915174/molecular-and-physiological-responses-of-iranian-perennial-ryegrass-as-affected-by-trinexapac-ethyl-paclobutrazol-and-abscisic-acid-under-drought-stress
#2
Mohammad Hossein Sheikh Mohammadi, Nematollah Etemadi, Mohammad Mehdi Arab, Mostafa Aalifar, Mostafa Arab, Mohammad Pessarakli
Drought stress is the major limiting factor which affects turfgrass management in area with restricted rainfall or irrigation water supply. Trinexapac ethyl (TE), Paclobutrazol (PAC) and Abscisic acid (ABA) are three plant growth regulators (PGRs) that are commonly used on turf species for increasing their tolerance to different environmental stresses such as drought. However, little is known about the impact of PGRs on stress tolerance of Iranian Perennial ryegrass (Lolium perenne). The present study was conducted to examine the visual and physiological changes of Iranian Perennial ryegrass in response to foliar application of TE, PAC, and ABA under drought stress conditions...
November 27, 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27915161/intestinal-multidrug-resistance-associated-protein-2-is-down-regulated-in-fructose-fed-rats
#3
Ana Sofía Londero, Maite Rocío Arana, Virginia Gabriela Perdomo, Guillermo Nicolás Tocchetti, Felipe Zecchinati, Carolina Inés Ghanem, María Laura Ruiz, Juan Pablo Rigalli, Aldo Domingo Mottino, Fabiana García, Silvina Stella Maris Villanueva
Expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2) and glutathione-S-transferase (GST) were examined in fructose fed Wistar rats, an experimental model of metabolic syndrome. Animals were fed on (a) control diet or (b) control diet plus 10% w/vol fructose in the drinking water. Mrp2 and the α class of GST proteins as well as their corresponding mRNAs were decreased, suggesting a transcriptional regulation by fructose. Confocal microscopy studies reaffirmed down-regulation of Mrp2...
November 9, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27915148/antioxidant-response-of-the-hard-shelled-mussel-mytilus-coruscus-exposed-to-reduced-ph-and-oxygen-concentration
#4
Yanming Sui, Menghong Hu, Yueyong Shang, Fangli Wu, Xizhi Huang, Sam Dupont, Daniela Storch, Hans-Otto Pörtner, Jiale Li, Weiqun Lu, Youji Wang
Ocean acidification (OA) and hypoxic events are increasing worldwide problems, their interactive effects have not been well clarified, although their co-occurrence is prevalent. The East China Sea (the Yangtze River estuary area) suffers from not only coastal hypoxia but also pH fluctuation, representing an ideal study site to explore the combined effect of OA and hypoxia on marine bivalves. We experimentally evaluated the antioxidant response of the mussel Mytilus coruscus exposed to three pH levels (8.1, 7...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27915147/highly-sensitive-optical-interferometric-technique-reveals-stress-dependent-instantaneous-nanometric-growth-fluctuations-of-chinese-chive-leaf-under-heavy-metal-stress
#5
Kokge Thilini Kanchana Muthumali DeSilva, Uma Maheswari Rajagopalan, Hirofumi Kadono
Plant growth apart from being a complex and highly dynamic is dependent on its immediate environment. Leaf expansion measurements using Statistical Interferometry Technique, a sensitive interferometric technique at nanometric accuracy and at sub-second levels revealed the presence of characteristic nanometric intrinsic fluctuations [Plant Biotechnology 31, 195 (2014)]. In this paper, we demonstrate that the nanometric intrinsic fluctuations are sensitive enough that they change under exposure of heavy metals, essential micronutrient zinc and non-essential element cadmium, at relatively low concentrations in the leaves of Chinese chive (Allium tuberosum)...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27915144/antioxidant-enzyme-and-osmotic-adjustment-changes-in-bean-seedlings-as-affected-by-biochar-under-salt-stress
#6
Salar Farhangi-Abriz, Shahram Torabian
Salinity damaged cellular membranes through overproduction of reactive oxygen species (ROS), while osmolytes and antioxidant capacities play a vital role in protecting plants from salinity caused oxidative damages. Biochar also could alleviate the negative impacts of salt stress in crops. The pot experiment was conducted to investigate the effects of biochar on some antioxidant enzyme activities and osmolyte adjustments of common bean (Phaseolus vulgaris L. cv. Derakhshan) under salinity stress. Bean plants were subjected to three salinity levels (non-saline, 6 and 12 dSm(-1) of NaCl) and biochar treatments (non-biochar, 10% and 20% total pot mass)...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27915142/atrazine-triggers-hepatic-oxidative-stress-and-apoptosis-in-quails-coturnix-c-coturnix-via-blocking-nrf2-mediated-defense-response
#7
Cong Zhang, Xue-Nan Li, Li-Run Xiang, Lei Qin, Jia Lin, Jin-Long Li
The bioaccumulation and environmental persistence of atrazine (ATZ) poses a severe hazard to animal ecosystem. Quail has strong sensitivity to environmental pollutant, thus it is one of the most important ecological pollution indicator. However, true proof for the effects of ATZ exposure on the liver of quails is lacking. To evaluate the liver injury and the role of Nrf2-mediated defense responses during ATZ exposure, male quails were treated with ATZ (0, 50, 250 and 500mg/kg) by oral gavage for 45 days. Histopathological and ultrastructural changes, oxidative stress indices, apoptosis-related factors and Nrf2 pathway were detected...
December 1, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27915048/protective-effects-of-green-tea-and-its-main-constituents-against-natural-and-chemical-toxins-a-comprehensive-review
#8
REVIEW
Maryam Rameshrad, Bibi Marjan Razavi, Hossein Hosseinzadeh
Toxins are natural or chemical poisonous substances with severe side effects on health. Humans are generally exposed by widespread toxic contaminations via air, soil, water, food, fruits and vegetables. Determining a critical antidote agent with extensive effects on different toxins is an ultimate goal for all toxicologists. Traditional medicine is currently perceived as a safe and natural approach against toxins. In this regard, we focused on the protective effects of green tea (Camellia sinensis) and its main components such as catechin, epicatechin, epicatechin gallate, gallocatechin, epigallocatechin and epigallocatechin gallate as a principal source of antioxidants against both natural and chemical toxins...
November 30, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27915041/garlic-active-constituent-s-allyl-cysteine-protects-against-lipopolysaccharide-induced-cognitive-deficits-in-the-rat-possible-involved-mechanisms
#9
Mahboubeh Zarezadeh, Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Mehrdad Roghani
Neuroinflammation is known as a risk factor for cognitive deficit and dementia and its incidence increased with aging. S-allyl cysteine (SAC) is the active and main component of aged garlic extract with anti-inflammatory, neuroprotective, and nootropic potential. In this study, the protective effect of SAC against lipopolysaccharide (LPS)-induced cognitive deficit in the rat was investigated. For induction of learning and memory impairment and neuroinflammation, LPS was intraperitoneally injected at a dose of 167 μg/kg for 7 days and SAC was administered p...
November 30, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27914996/long-term-organic-selenium-supplementation-overcomes-the-trade-off-between-immune-and-antioxidant-systems-in-pacu-piaractus-mesopotamicus
#10
Leonardo Susumu Takahashi, Jaqueline Dalbello Biller-Takahashi, Cleber Fernando Menegasso Mansano, Elisabeth Criscuolo Urbinati, Rodrigo Yukihiro Gimbo, Marcos Vinícius Saita
Selenium (Se) is an essential nutrient for antioxidant defenses in fish because of its role in preventing immunosuppression caused by oxidative stress. In this study it was demonstrated the relation between the oxidative stress and immune status after a long Se supplementation period, as a result of the evaluation of immunological, hematological and antioxidant responses, as well as growth performance of pacu fed diets supplemented with different concentrations of organic selenium (0, 0.3, 0.6, 0.9, and 1.8 mg Se-yeast/kg, but the final analyzed selenium concentrations were 0...
November 30, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27914990/presence-of-melanopsin-in-human-crystalline-lens-epithelial-cells-and-its-role-in-melatonin-synthesis
#11
Hanan Awad Alkozi, Xiaoyu Wang, Maria Jesus Perez de Lara, Jesus Pintor
Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is considered to have light regulated tasks among other functions. In the present work, melanopsin presence in human lens epithelial cells as well as in human lens tissue is described for the first time. Moreover, studying the concentration of melatonin and its synthesising enzyme AANAT proved a clear link between melanopsin activation and the suppression of melatonin synthesis. Melanopsin sensitivity to specific wavelength (465-480 nm, blue) was confirmed after making temporal studies incubating lens epithelial cells under light, red, green, blue and total darkness for 2, 4, 8, 12 h and analysing the concentration of both melatonin and its synthesising enzyme AANAT, discovering that melatonin levels after submitting cells to total darkness are significantly higher to ones submitted to white or specifically blue light (***p < 0...
November 30, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27914964/antioxidant-and-hemolytic-activities-and-effects-in-rat-cutaneous-wound-healing-of-a-novel-polysaccharide-from-fenugreek-trigonella-foenum-graecum-seeds
#12
Naourez Ktari, Imen Trabelsi, Sana Bardaa, Mehdi Triki, Intidhar Bkhairia, Rabab Ben Slama-Ben Salem, Moncef Nasri, Riadh Ben Salah
The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenum-graecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes. The application of FWEP hydrogel on the wound site in a rat model enhanced significantly wound healing activity and accelerated the wound closure after 14days of wound induction...
November 30, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27914891/antioxidant-capacities-of-fucoxanthin-producing-algae-as-influenced-by-their-carotenoid-and-phenolic-contents
#13
Su Chern Foo, Fatimah Md Yusoff, Maznah Ismail, Mahiran Basri, Sook Kun Yau, Nicholas M H Khong, Kim Wei Chan, Mahdi Ebrahimi
Natural antioxidants from sustainable sources are favoured to accommodate worldwide antioxidant demand. In addition to bioprospecting for natural and sustainable antioxidant sources, this study aimed to investigate the relationship between the bioactives (i.e. carotenoid and phenolic acids) and the antioxidant capacities in fucoxanthin-producing algae. Total carotenoid, phenolic acid, fucoxanthin contents and fatty acid profile of six species of algae (five microalgae and one macroalga) were quantified followed by bioactivity evaluation using four antioxidant assays...
November 30, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27914828/oleuropein-protects-l-02-cells-against-h2o2-induced-oxidative-stress-by-increasing-sod1-gpx1-and-cat-expression
#14
Ce Shi, Xiangrong Chen, Zuojia Liu, Rizeng Meng, Xingchen Zhao, Zonghui Liu, Na Guo
Oleuropein (OL), a natural phenolic compound, comprises the major constituent of Olea europea leaves and unprocessed olives, and OL is considered to be the principal components that confer the characteristic taste and stability of olive oil. Oxidative damage induced by H2O2 treatment can irreversibly damage the L-02 cells, resulting in cell death and apoptosis. Whether the effects of oxidative stress could be attenuated in cultured human L-02 cells by incubation with OL is still unknown. In this research, the function of OL in protecting human L-02 cells against H2O2 induced cell death and cell apoptosis was investigated, and the mechanism by which OL underlies the effect was also examed...
November 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27914825/amelioration-of-ischemia-reperfusion-induced-functional-and-biochemical-deficit-in-mice-by-ocimum-kilimandscharicum-leaf-extract
#15
Varinder Singh, Pawan Krishan, Nirmal Singh, Amit Kumar, Richa Shri
The genus Ocimum (family Lamiaceae) has been revered for its diverse biological activities. Various species have been used traditionally to treat CNS disorders and are proven to have neuroprotective effect that is often attributed to their significant antioxidant activity. Ocimum kilimandscharicum (Karpoora Thulasi), a prominent member of this genus is reported to have marked antioxidant activity but its neuroprotective potential has not been explored. Thus, present study was designed to evaluate the cerebroprotective effect of O...
November 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27914822/effects-of-sodium-thiosulfate-versus-observation-on-development-of-cisplatin-induced-hearing-loss-in-children-with-cancer-accl0431-a-multicentre-randomised-controlled-open-label-phase-3-trial
#16
David R Freyer, Lu Chen, Mark D Krailo, Kristin Knight, Doojduen Villaluna, Bonnie Bliss, Brad H Pollock, Jagadeesh Ramdas, Beverly Lange, David Van Hoff, Michele L VanSoelen, John Wiernikowski, Edward A Neuwelt, Lillian Sung
BACKGROUND: Sodium thiosulfate is an antioxidant shown in preclinical studies in animals to prevent cisplatin-induced hearing loss with timed administration after cisplatin without compromising the antitumour efficacy of cisplatin. The primary aim of this study was to assess sodium thiosulfate for prevention of cisplatin-induced hearing loss in children and adolescents. METHODS: ACCL0431 was a multicentre, randomised, open-label, phase 3 trial that enrolled participants at 38 participating Children's Oncology Group hospitals in the USA and Canada...
November 30, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27914541/two-new-fatty-acids-esters-were-detected-in-ginseng-stems-by-the-application-of-azoxystrobin-and-the-increasing-of-antioxidant-enzyme-activity-and-ginsenosides-content
#17
Shuang Liang, Xuan-Wei Xu, Xiao-Feng Zhao, Zhi-Guang Hou, Xin-Hong Wang, Zhong-Bin Lu
Panax ginseng C.A. Meyer is a valuable herb in China that has also gained popularity in the West because of its pharmacological properties. The constituents isolated and characterized in ginseng stems include ginsenosides, fatty acids, amino acids, volatile oils, and polysaccharides. In this study, the effects of fungicide azoxystrobin applied on antioxidant enzyme activity and ginsenosides content in ginseng stems was studied by using Panax ginseng C. A. Mey. cv. (the cultivar of Ermaya) under natural environmental conditions...
November 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27914539/the-effects-of-alpha-cypermethrin-exposure-on-biochemical-and-redox-parameters-in-pregnant-rats-and-their-newborns
#18
Leila Hocine, Hafida Merzouk, Sid Ahmed Merzouk, Hafeda Ghorzi, Meriem Youbi, Michel Narce
Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined...
November 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27914532/identification-of-antioxidant-activity-of-two-new-aromatic-ring-butyrolactone-derivatives-from-dictamnus-dasycarpus-turcz
#19
Li-Na Guo, Yue-Hu Pei, Fei-Xiang Xie, Lei Liu, Huan Cong, Hong-Xia Cui, Xiao-Li Wang, Wen-Jing Li, Bai-Yu Jian, Ji-Cheng Liu
The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A (1) and dasycarpusphenol acid B (2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC50 values being 28.95 and 41.76 mg·mL(-1), respectively.
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914512/moderate-intake-of-docosahexaenoic-acid-raises-plasma-and-platelet-vitamin-e-levels-in-cystic-fibrosis-patients
#20
Evelyne Véricel, Stéphane Mazur, Romain Colas, Véronique Delaup, Catherine Calzada, Philippe Reix, Isabelle Durieu, Michel Lagarde, Gabriel Bellon
Patients with cystic fibrosis have increased oxidative stress and impaired antioxidant systems. Moderate intake of docosahexaenoic acid (DHA) may favor the lowering of oxidative stress. In this randomized, double-blind, cross-over study, DHA or placebo capsules, were given daily to 10 patients, 5mg/kg for 2 weeks then 10mg/kg DHA for the next 2 weeks (or placebo). After 9 weeks of wash-out, patients took placebo or DHA capsules. Biomarkers of lipid peroxidation and vitamin E were measured at baseline, and after 2 and 4 weeks of treatment in each phase...
December 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
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