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https://www.readbyqxmd.com/read/29793180/insulin-is-a-potential-antioxidant-for-diabetes-associated-cognitive-decline-via-regulating-nrf2-dependent-antioxidant-enzymes
#1
Ying Song, Wei Ding, Yun Bei, Yan Xiao, Hai-Da Tong, Li-Bo Wang, Li-Yao Ai
PURPOSE: To investigate the neuroprotective effects of insulin on diabetic encephalopathy and its mechanism. EXPERIMENTAL AND APPROACH: The diabetic model was established by injection of streptozotocin. Behavior examinations were conducted by the Morris water maze. Histopathological alterations were detected by HE staining. ROS, CAT levels and SOD activity were measured using a microplate reader. In vitro, the viability of wild type and knock-down PC12 cells was detected by MTT assay, the morphology of cells was monitored under a microscope...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793168/olive-oil-polyphenols-reduce-oxysterols-induced-redox-imbalance-and-pro-inflammatory-response-in-intestinal-cells
#2
Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M Paola Melis, Carlo I G Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial layer and thus contributing to the pathogenesis of human inflammatory bowel diseases and colon cancer. Extra virgin olive oil polyphenols possess antioxidant and anti-inflammatory properties, and concentrate in the intestinal lumen, where may help in preventing intestinal diseases...
May 16, 2018: Redox Biology
https://www.readbyqxmd.com/read/29792965/characterization-sulfated-modification-and-bioactivity-of-a-novel-polysaccharide-from-millettia-dielsiana
#3
Zhonghua Wang, Tongqiang Cai, Xipu He
Millettia dielsiana is a traditional herb medicine to treat rheumatic arthritis and gynecological diseases. In this study, a novel polysaccharide (MDP1) with a molecular weight of 139.54 kDa was isolated from Millettia dielsiana by DEAE-52 cellulose chromatography. Its sulfated derivative (S-MDP1) was prepared by the chlorosulfonic acid-pyridine method. Structural analysis indicated that MDP1 was a pectic polysaccharide and did not exhibit a triple helical conformation. In vitro, MDP1 and S-MDP1 had protective effect on H2 O2 -induced PC12 cells death...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792963/extraction-characterization-and-biological-activity-of-sulfated-polysaccharides-from-seaweed-dictyopteris-divaricata
#4
Yinxin Cui, Xin Liu, Shufang Li, Limin Hao, Juan Du, DaHai Gao, Qiaozhen Kang, Jike Lu
Dictyopteris divaricata is a kind of important brown algae with many biological activities. It has been receiving more and more attention, yet there are rarely studies done on its polysaccharides. In this study, the optimum extraction and biological activity of seaweed polysaccharides from Dictyopteris divaricata (DDSP) were investigated. Response surface methodology (RSM), based on a three-level, three-variable Box-Behnken design (BBD), was employed to obtain the best possible combinations for maximum polysaccharides yield...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792955/fisetin-alleviates-oxidative-stress-after-traumatic-brain-injury-via-the-nrf2-are-pathway
#5
Li Zhang, Handong Wang, Yali Zhou, Yihao Zhu, Maoxin Fei
Fisetin, a natural flavonoid, has neuroprotection properties in many brain injury models. However, its role in traumatic brain injury (TBI) has not been fully explained. In the present study, we aimed to explore the neuroprotective effects of fisetin in a mouse model of TBI. We found that fisetin improved neurological function, reduced cerebral edema, attenuated brain lesion and ameliorated blood-brain barrier (BBB) disruption after TBI. Moreover, the up-regulation of malondialdehyde (MDA) and the activity of glutathione peroxidase (GPx) were reversed by fisetin treatment...
May 21, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29792923/high-throughput-sequencing-identifies-chilling-responsive-genes-in-sweetpotato-ipomoea-batatas-lam-during-storage
#6
Zeyi Xie, Zhilin Zhou, Hongmin Li, Jingjing Yu, Jiaojiao Jiang, Zhonghou Tang, Daifu Ma, Baohong Zhang, Yonghua Han, Zongyun Li
Sweetpotato (Ipomoea batatas L.) is a globally important economic food crop. It belongs to Convolvulaceae family and origins in the tropics; however, sweetpotato is sensitive to cold stress during storage. In this study, we performed transcriptome sequencing to investigate the sweetpotato response to chilling stress during storage. A total of 110,110 unigenes were generated via high-throughput sequencing. Differentially expressed genes (DEGs) analysis showed that 18,681 genes were up-regulated and 21,983 genes were down-regulated in low temperature condition...
May 21, 2018: Genomics
https://www.readbyqxmd.com/read/29792813/metabolomics-reveals-the-molecular-mechanisms-of-copper-induced-cucumber-leaf-cucumis-sativus-senescence
#7
Lijuan Zhao, Yuxiong Huang, Kelly Paglia, Arpana Vaniya, Benjamin Wancewicz, Arturo A Keller
Excess copper may disturb plant photosynthesis and induce leaf senescence. The underlying toxicity mechanism is not well understood. Here, 3-week-old cucumber plants were foliar exposed to different copper concentrations (10, 100 and 500 mg/L) for a final dose of 0.21, 2.1 and 10 mg/plant, using CuSO4 as the Cu ion source for seven days, three times per day. Metabolomics quantified 149 primary and 79 secondary metabolites. A number of intermediates of the tricarboxylic acid (TCA) cycle were significantly down-regulated 1...
May 24, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29792358/in-vitro-activities-of-ceiba-speciosa-a-st-hil-ravenna-aqueous-stem-bark-extract
#8
Juliana Andréa Dörr, Shanna Bitencourt, Luísa Bortoluzzi, Celso Alves, Joana Silva, Stefani Stoll, Susete Pinteus, Aline Augusti Boligon, Roberto Christ Vianna Santos, Stefan Laufer, Rui Pedrosa, Márcia Inês Goettert
Several species of the genus Ceiba (Malvaceae) are ethnopharmacologically used. Thus, this study aimed to investigate the in vitro beneficial properties of the aqueous stem bark extract of Ceiba speciosa. The extract presented a great amount of phenolic compounds (117.4 ± 6.2 mg GAE/g). The antioxidant activity was assessed by DPPH (IC50  = 42.87 μg/mL), ORAC (2351.17 μmol TE/g) and FRAP (235.94 μM FeSO4 /g) methods. In addition, the extract reduced MCF-7 cell viability as assessed by MTT. However, it prevented mitochondrial membrane depolarization and reduced caspase-9 activity induced by hydrogen peroxide...
May 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29792351/peroxiredoxin-6-inhibits-osteogenic-differentiation-and-bone-formation-through-human-dental-pulp-stem-cells-and-induces-delayed-bone-development
#9
Kyung-Ran Park, Hyung-Mun Yun, In Jun Yeo, Sehyung Cho, Jin Tae Hong, Yong Seok Jeong
AIMS: Peroxiredoxins (PRDXs) are thiol-specific antioxidant enzymes that regulate redox balance that are critical for maintaining the cellular potential for self-renewal and stemness. Stem cell-based regenerative medicine is a promising approach in tissue reconstruction. However, to obtain functional cells for use in clinical applications, stem cell technology still requires improvements. RESULTS: In the present study, we found that PRDX6 levels were decreased during osteogenic differentiation in human dental pulp stem cells (hDPSCs)...
May 24, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29792236/evaluation-of-gamma-radiation-induced-biochemical-changes-in-skin-for-dose-assesment-a-study-on-small-experimental-animals
#10
Sandeep Kumar Soni, Mitra Basu, Priyanka Agrawal, Aseem Bhatnagar, Neelam Chhillar
OBJECTIVE: Researchers have been evaluating several approaches to assess acute radiation injury/toxicity markers owing to radiation exposure. Keeping in mind this background, we assumed that whole-body irradiation in single fraction in graded doses can affect the antioxidant profile in skin that could be used as an acute radiation injury/toxicity marker. METHODS: Sprague-Dawley rats were treated with CO-60 gamma radiation (dose: 1-5 Gy; dose rate: 0.85 Gy/minute)...
May 24, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29792214/association-of-serum-bilirubin-level-with-lung-function-decline-a-korean-community-based-cohort-study
#11
Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang, Ji Ye Jung
BACKGROUND: Bilirubin has been reported to be associated with respiratory diseases due to its antioxidant action. We aimed to evaluate the relationship between serum bilirubin concentration and annual lung function decline in the Korean general population. METHODS: The study included 7986 subjects aged 40-69 years from the Ansung-Ansan cohort database I (2001-2002)-III (2005-2006). We analyzed the relationships between serum bilirubin level and forced expiratory volume in 1 s (FEV1 ), forced vital capacity (FVC), FEV1 /FVC, and mean forced expiratory flow between 25 and 75% of FVC (FEF25-75% ) at baseline, as well as the annual average changes in these lung parameters...
May 23, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29792194/comparison-of-aqueous-polyethylene-glycol-aqueous-and-ethanolic-propolis-extracts-antioxidant-and-mitochondria-modulating-properties
#12
Loreta Kubiliene, Aiste Jekabsone, Modestas Zilius, Sonata Trumbeckaite, Daiva Simanaviciute, Rima Gerbutaviciene, Daiva Majiene
BACKGROUND: Propolis is multicomponent substance collected by honeybees from various plants. It is known for numerous biological effects and is commonly used as ethanolic extract because most of active substances of propolis are ethanol-soluble. However, water-based propolis extracts could be applied more safely, as this solvent is more biocompatible. On the other hand, water extracts has significantly smaller range and quantity of active compounds. The extraction power of water could be enhanced by adding co-solvent which increases both solubility and penetration of propolis compounds...
May 23, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29792126/neuropathological-profile-of-the-pentylenetetrazol-ptz-kindling-model
#13
E Samokhina, Alexander Samokhin
Epilepsy is a complex neurological disease characterized by spontaneous episodes of abnormal, simultaneous firing of a neuronal population and disturbances of consciousness (so-called seizures) of unknown cause. Antiepileptic drugs are only symptomatic treatment, and there is a strong demand for the search of an alternative treatment of epilepsy. For this purpose, animal models of epilepsy are an important prerequisite. There are various animal models with chronic brain dysfunctions thought to reflect the processes underlying human epilepsy...
May 23, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29792085/role-of-selenium-supplementation-in-prevention-of-late-onset-sepsis-among-very-low-birth-weight-neonates-a-systematic-review-of-randomized-controlled-trials
#14
Bhawan Garg, Anju Bansal, Nandkishor Kabra
BACKGROUND: Neonatal sepsis is one of the most common cause of neonatal morbidity and mortality. Selenium has antioxidant and immune-modulating properties. AIM: The aim of this systematic review is to evaluate role of selenium supplementation in the prevention of late onset sepsis (LOS) among very low birth weight (VLBW) neonates. METHODS: We searched literature for this review by searching the Cochrane Central Register of Controlled Trials (CENTRAL) electronic PubMed, Embase and Google Scholar...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29792055/the-effect-of-the-modes-of-delivery-on-the-maternal-and-neonatal-dynamic-thiol-disulfide-homeostasis
#15
Dilek Ulubas Isik, Yıldız Akdaş Reis, Ahmet Yagmur Bas, Sezin Unal, Beyza Ozcan, Leyla Mollamahmutoğlu, Salim Neselioglu, Ozcan Erel, Nihal Demirel
BACKGROUND: Thiols are organic compounds containing sulfhydryl groups which exert antioxidant effects via dynamic thiol-disulfide homeostasis. The shift towards disulfide indicates the presence of oxidative environment. The thiol-disulfide homeostasis has not been studied in different mode of delivery before. AIMS: To investigate the effects of mode of parturition on the thiol-disulfide homeostasis in mothers and term infants. STUDY DESIGN: The participants were grouped according to the mode of their delivery: vaginal delivery group (vaginal delivery (VD), n = 40) and cesarean group (C/S, n = 40)...
May 23, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29791976/a-cipk-protein-kinase-targets-sucrose-transporter-mdsut2-2-at-ser-254-for-phosphorylation-to-enhance-salt-tolerance
#16
Qi-Jun Ma, Mei-Hong Sun, Hui Kang, Jing Lu, Chun-Xiang You, Yu-Jin Hao
Soil salinity is one of the major abiotic stressors that negatively affect crop growth and yield. Salt stress can regulate antioxidants and the accumulation of osmoprotectants. In the study, a sucrose transporter MdSUT2.2 was identified in apple. Overexpression of MdSUT2.2 gene increased salt tolerance in the transgenic apple, compared with the WT control 'Gala'. In addition, it was found that protein MdSUT2.2 was phosphorylated at Ser254 site in response to salt. A DUAL membrane yeast hybridization system through an apple cDNA library demonstrated that a protein kinase MdCIPK13 interacted with MdSUT2...
May 23, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29791772/characterization-culture-medium-optimization-and-antioxidant-activity-of-an-endophytic-vitexin-producing-fungus-dichotomopilus-funicola-y3-from-pigeon-pea-cajanus-cajan-l-millsp
#17
C B Gu, H Ma, W J Ning, L L Niu, H Y Han, X H Yuan, Y J Fu
AIMS: The aim of this study was to characterize a fungal endophyte Y3 from pigeon pea (Cajanus cajan [L.] Millsp), as a novel producer of vitexin, and its culture medium optimization and antioxidant activity. METHODS AND RESULTS: The endophyte from the leaves of pigeon pea was identified as Dichotomopilus funicola by the morphological and molecular characteristics. The most important medium variables affecting vitexin production in liquid culture of D. funicola Y3 were screened by Plackett-Burman design, and three culture medium constituents (i...
May 23, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29791760/neopterin-7-8-dihydroneopterin-is-elevated-in-duchenne-muscular-dystrophy-patients-and-protects-mdx-skeletal-muscle-function
#18
Angus Lindsay, Alexandra Schmiechen, Christopher M Chamberlain, James M Ervasti, Dawn A Lowe
Macrophage infiltration is a hallmark of dystrophin-deficient muscle. We tested the hypothesis that Duchenne muscular dystrophy (DMD) patients would have elevated levels of the macrophage synthesized pterins, neopterin and 7,8-dihydroneopterin compared to unaffected age-matched controls. Urinary neopterin/creatinine and 7,8-dihydroneopterin/creatinine were elevated in DMD patients and 7,8-dihydroneopterin/creatinine was associated with patient age and ambulation. 7,8-dihydroneopterin correction with specific gravity was also elevated in DMD patients...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29791650/metabolic-syndrome-components-are-associated-with-oxidative-stress-in-overweight-and-obese-patients
#19
Nayara Rampazzo Morelli, Bruna Miglioranza Scavuzzi, Lucia Helena da Silva Miglioranza, Marcell Alysson Batisti Lozovoy, Andréa Name Colado Simão, Isaias Dichi
OBJECTIVE: The aim of this study is to evaluate the influence of the body mass index (BMI) and the metabolic syndrome (MetS) parameters on oxidative and nitrosative stress in overweight and obese subjects. SUBJECTS AND METHODS: Individuals were divided into three groups: the control group (G1, n = 131) with a BMI between 20 and 24.9 kg/m2, the overweight group (G2, n = 120) with a BMI between 25 and 29.9 kg/m2 and the obese group (G3, n = 79) with a BMI ≥ 30 kg/m2...
May 17, 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29791598/chemical-characterization-antioxidant-and-antimicrobial-activity-of-propolis-obtained-from-melipona-quadrifasciata-quadrifasciata-and-tetragonisca-angustula-stingless-bees
#20
A R Torres, L P Sandjo, M T Friedemann, M M Tomazzoli, M Maraschin, C F Mello, A R S Santos
In this study, we investigated the chemical composition, and antioxidant and antibacterial properties of ethanolic extracts of propolis (EEP) from Melipona quadrifasciata quadrifasciata and Tetragonisca angustula. Chemical composition of EEP was determined by colorimetry and chromatographic (HPLC-DAD and UPLC-Q/TOF-MS/MS) analysis. Antimicrobial activity of EEP was evaluated against gram-positive (S. aureus, methicillin-resistant S. aureus, E. faecalis) and gram-negative (E. coli and K. pneumoniae) bacteria by the minimal inhibitory concentration (MIC) test using the microdilution method...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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