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https://www.readbyqxmd.com/read/28742983/should-adults-with-diabetes-mellitus-be-vaccinated-against-hepatitis-b-virus-a-systematic-review-of-diabetes-mellitus-and-the-progression-of-hepatitis-b-disease
#1
Zobair Younossi, Katrin Kochems, Marc de Ridder, Desmond Curran, Eveline M Bunge, Laurence de Moerlooze
Despite the burden of diabetes mellitus (DM), little is known about the role of this and other metabolic syndromes on the severity of hepatitis B virus (HBV) chronicity and liver disease progression. The value of hepatitis B vaccination and its impact on liver diseases and HCC has been largely demonstrated (ref), adult vaccination coverage is however suboptimal and DM diagnosis represents an opportunity for the HCP to discuss hepatitis B and other adult vaccinations. We performed a systematic literature search to identify studies (2000 to January 2017) describing liver disease progression among patients with HBV by DM status...
July 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28742866/contribution-of-factor-h-binding-protein-sequence-to-the-cross-reactivity-of-meningococcal-native-outer-membrane-vesicle-vaccines-with-over-expressed-fhbp-variant-group-1
#2
Arianna Marini, Omar Rossi, Maria Grazia Aruta, Francesca Micoli, Simona Rondini, Serafina Guadagnuolo, Isabel Delany, Ian R Henderson, Adam F Cunningham, Allan Saul, Calman A MacLennan, Oliver Koeberling
Factor H-binding protein (fHbp) is an important meningococcal vaccine antigen. Native outer membrane vesicles with over-expressed fHbp (NOMV OE fHbp) have been shown to induce antibodies with broader functional activity than recombinant fHbp (rfHbp). Improved understanding of this broad coverage would facilitate rational vaccine design. We performed a pair-wise analysis of 48 surface-exposed amino acids involved in interacting with factor H, among 383 fHbp variant group 1 sequences. We generated isogenic NOMV-producing meningococcal strains from an African serogroup W isolate, each over-expressing one of four fHbp variant group 1 sequences (ID 1, 5, 9, or 74), including those most common among invasive African meningococcal isolates...
2017: PloS One
https://www.readbyqxmd.com/read/28742139/acquisition-of-c1-inhibitor-by-bordetella-pertussis-virulence-associated-gene-8-results-in-c2-and-c4-consumption-away-from-the-bacterial-surface
#3
Elise S Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H M Rooijakkers, Ilse Jongerius
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on complement evasion strategies of this pathogen is limited. However, this is of great importance for future vaccine development as it has become apparent that a novel pertussis vaccine is needed. Here, we unravel the effect of Virulence associated gene 8 (Vag8) of B. pertussis on the human complement system at the molecular level...
July 24, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28740850/the-role-of-dog-population-management-in-rabies-elimination-a-review-of-current-approaches-and-future-opportunities
#4
REVIEW
Louise H Taylor, Ryan M Wallace, Deepashree Balaram, Joann M Lindenmayer, Douglas C Eckery, Beryl Mutonono-Watkiss, Ellie Parravani, Louis H Nel
Free-roaming dogs and rabies transmission are integrally linked across many low-income countries, and large unmanaged dog populations can be daunting to rabies control program planners. Dog population management (DPM) is a multifaceted concept that aims to improve the health and well-being of free-roaming dogs, reduce problems they may cause, and may also aim to reduce dog population size. In theory, DPM can facilitate more effective rabies control. Community engagement focused on promoting responsible dog ownership and better veterinary care could improve the health of individual animals and dog vaccination coverage, thus reducing rabies transmission...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28739327/patterns-of-use-of-human-papillomavirus-and-other-adolescent-vaccines-in-the-united-states
#5
Nadja A Vielot, Anne M Butler, M Alan Brookhart, Sylvia Becker-Dreps, Jennifer S Smith
PURPOSE: The purpose of the study was to describe the patterns of use of universally recommended adolescent vaccines in the United States. METHODS: We identified 11-year-olds using the MarketScan insurance claims database (2009-2014). Human papillomavirus (HPV), tetanus-diphtheria-acellular pertussis (Tdap), and meningococcal (MenACWY) vaccination claims were identified using diagnosis and procedure codes. Generalized linear models estimated vaccination incidence rates and correlates of adolescent vaccination and timely vaccination...
July 21, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28738137/public-health-and-economic-consequences-of-vaccine-hesitancy-for-measles-in-the-united-states
#6
Nathan C Lo, Peter J Hotez
Importance: Routine childhood vaccination is declining in some regions of the United States due to vaccine hesitancy, which risks the resurgence of many infectious diseases with public health and economic consequences. There are ongoing policy debates on the state and national level, including legislation around nonmedical (personal-belief) exemptions for childhood vaccination and possibly a special government commission on vaccine safety, which may affect vaccine coverage. Objective: To estimate the number of measles cases in US children and the associated economic costs under scenarios of different levels of vaccine hesitancy, using the case example of measles, mumps, and rubella (MMR) vaccination and measles...
July 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28737627/direct-and-indirect-effectiveness-of-the-ten-valent-pneumococcal-conjugate-vaccine-against-carriage-in-a-cluster-randomized-trial
#7
Arto A Palmu, Maija Toropainen, Tarja Kaijalainen, Lotta Siira, Mika Lahdenkari, Heta Nieminen, Ritva K Syrjänen, Terhi M Kilpi, Jukka Jokinen
Finnish Invasive Pneumococcal disease (FinIP) vaccine trial was designed to evaluate effectiveness of ten-valent pneumococcal conjugate vaccine (PHiD-CV10, GSK). We conducted two satellite studies to evaluate PHiD-CV10 effectiveness against pneumococcal carriage in FinIP-vaccinated children (long-term direct and indirect effectiveness combined) and in their unvaccinated siblings (indirect effectiveness within the family).FinIP was a cluster-randomized trial, where >47000 children <19 months of age were recruited 2009-2010...
July 21, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28737338/-attitudes-and-practices-towards-seasonal-influenza-vaccination-amongst-french-hospital-staff
#8
Max Maurette, Pierre Pinzelli, Aleksandar Yordanov Sandev, Francis Nock
<ce:para>This survey intends to describe the attitudes towards vaccination amongst the hospital staff in the region of Castres, in the south-west of France, and their influenza vaccination coverage. A questionnaire was attached to all pay slips in March 2014 and 471 questionnaires were completed (return rate: 22.4%). Seasonal influenza vaccination coverage rate was similar to that reported in other French surveys. Paramedical personnel were less commonly immunized against influenza compared to medical personnel and age was the major factor associated with vaccination...
April 27, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/28737075/socialization-indifference-and-convenience-exploring-the-uptake-of-influenza-vaccine-among-medical-students-and-early-career-doctors
#9
Rhiannon Edge, Dawn Goodwin, Rachel Isba, Thomas Keegan
The Chief Medical Officer recommends that all health care workers receive an influenza vaccination annually. High vaccination coverage is believed to be the best protection against the spread of influenza within a hospital, although uptake by health care workers remains low. We conducted semistructured interviews with seven medical students and nine early career doctors, to explore the factors informing their influenza vaccination decision making. Data collection and analysis took place iteratively, until theoretical saturation was achieved, and a thematic analysis was performed...
July 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28736200/the-web-and-public-confidence-in-mmr-vaccination-in-italy
#10
Francesco Aquino, Gabriele Donzelli, Emanuela De Franco, Gaetano Privitera, Pier Luigi Lopalco, Annalaura Carducci
Measles, mumps and rubella (MMR) vaccination coverage in Italy has been decreasing starting from 2012 and, at the present, none of the Italian regions has achieved the goal of 95% coverage target. A decision of the Court of Justice of Rimini in March 2012 that awarded vaccine-injury compensation for a case of autism has been indicated as a probable trigger event leading to a reduction of vaccine confidence in Italy. The aim of the study was to explore the relationship between MMR vaccination coverage to online search trends and social network activity on the topic "autism and MMR vaccine", during the period 2010-2015...
July 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28730379/vaccine-effectiveness-against-influenza-in-2015-16-in-hospital-and-ambulatory-medical-care-facilities-polish-results-of-the-european-i-move-multicenter-study
#11
Iwona Paradowska-Stankiewicz, Monika R Korczyńska, Katarzyna Cieślak, Dorota Kowalczyk, Karol Szymański, Lidia B Brydak
Influenza vaccination is the best measure available to prevent seasonal influenza infection. The majority of studies on vaccine effectiveness in the 2015/16 season conducted in the European I-MOVE+ Project, show that a match between the circulating influenza strains in the general public and those included in the vaccine for the Northern Hemisphere was low to moderate. As part of I-MOVE+, Poland has implemented a case control negative study design and molecular biology methods, such as real time RT-PCR, to assess the vaccine match and effectiveness...
July 21, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28729954/clinical-streptococcal-isolates-distinct-from-streptococcus-pneumoniae-but-containing-the-%C3%AE-glucosyltransferase-tts-gene-and-expressing-serotype-37-capsular-polysaccharide
#12
Carmen L Sheppard, Georgia Kapatai, Karen Broughton, Ulf Schaefer, Matthew Hannah, David J Litt, Norman K Fry
The major virulence factor of the pneumococcus, and target for conjugate vaccines, is the polysaccharide capsule, which is usually encoded by the highly variable cps locus. Serotype 37 is an unusual pneumococcal type in which the single β-glucosyltransferase gene responsible for serotype capsule production (tts) is located outside of the capsular operon region. Using a previously described automated whole genome sequence (WGS)-based serotyping bioinformatics tool, PneumoCaT, we identified and investigated seven clinical isolates (three from blood cultures) of non-pneumococcal streptococci containing a highly homologous tts and included them in a study panel of 20 isolates which included a 11 further clinical isolates of S...
2017: PeerJ
https://www.readbyqxmd.com/read/28729316/relationship-between-receipt-of-substitutable-for-fee-vaccines-and-completion-of-the-expanded-programme-on-immunisation-a-cross-sectional-study-in-fujian-china
#13
Jiang-Nan Wu, Da-Jin Li, Yong Zhou, Mei-Rong Du, Hai-Lan Piao
OBJECTIVE: The aim of this study was to evaluate the relationship between receipt of the substitutable-for-fee vaccines (SFV) and completion of the expanded programme on immunisation (EPI). DESIGN AND SETTINGS: A cross-sectional study was conducted in Fujian province, China. PARTICIPANTS: Children who were born from 1 September 2009 to 31 August 2011, and who had been residing in the township for at least 3 months, were randomly recruited from 34 townships...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28727678/progress-toward-measles-elimination-bangladesh-2000-2016
#14
Sudhir Khanal, Rajendra Bohara, Stephen Chacko, Mohammad Sharifuzzaman, Mohammad Shamsuzzaman, James L Goodson, Alya Dabbagh, Katrina Kretsinger, Deepak Dhongde, Jayantha Liyanage, Sunil Bahl, Arun Thapa
In 2013, at the 66th session of the Regional Committee of the World Health Organization (WHO) South-East Asia Region (SEAR), a regional goal was established to eliminate measles and control rubella and congenital rubella syndrome* by 2020 (1). WHO-recommended measles elimination strategies in SEAR countries include 1) achieving and maintaining ≥95% coverage with 2 doses of measles-containing vaccine (MCV) in every district, delivered through the routine immunization program or through supplementary immunization activities (SIAs)(†); 2) developing and sustaining a sensitive and timely measles case-based surveillance system that meets targets for recommended performance indicators; and 3) developing and maintaining an accredited measles laboratory network (2)...
July 21, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28722581/epidemiology-of-diphtheria-in-india-1996-2016-implications-for-prevention-and-control
#15
Manoj Murhekar
Diphtheria is an acute disease caused by exotoxin-producing Corynebacterium diphtheriae. Globally, diphtheria has been showing a declining trend due to effective childhood vaccination programs. A substantial proportion of global burden of diphtheria is contributed by India. Hospital-based surveillance studies as well as diphtheria outbreaks published in last 20 years (1996-2016) indicate that diphtheria cases are frequent among school-going children and adolescents. In some Indian states, Muslim children are affected more...
June 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721342/hepatitis-b-virus-genotype-e-infection-among-egyptian-health-care-workers
#16
Reem Elmaghloub, Ashraf Elbahrawy, Gamal El Didamony, Ahmed Elwassief, Abdel-Gawad Saied Mohammad, Ahmed Alashker, Hendawy Zedan, Abdallah Mahmoud Abdallah, Mahmoud Haddad Hemidah, Amr Elmestikawy, Mohamed El Fayoumei, Hossam Shahba, Ahmed Gawish, Mohamed Hanafy Morsy, Alaa Hashim, Mohamed Ali Abdelbaseer, Yoshihide Ueda, Tsutomu Chiba, Hafez Abdelhafeez
BACKGROUND AND OBJECTIVES: Health Care Workers (HCWs) are at a high risk of needle stick injuries and HBV infection in Egypt; this problem is further aggravated by low Hepatitis B (HB) vaccination coverage. Limited data are available on the prevalence of HBV infection in Egyptian HCWs. In this study, we aimed to assess the HBV infection rate and genotypes among Egyptian HCWs. METHODS: Five hundred and sixty-four (564) HCWs were included. Of them, 258 (45.74%) were health care providers and 306 (54...
June 2017: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/28720851/microneedle-patch-delivery-of-influenza-vaccine-during-pregnancy-enhances-maternal-immune-responses-promoting-survival-and-long-lasting-passive-immunity-to-offspring
#17
E Stein Esser, Joanna A Pulit-Penaloza, Haripriya Kalluri, Devin McAllister, Elena V Vassilieva, Elizabeth Q Littauer, Nadia Lelutiu, Mark R Prausnitz, Richard W Compans, Ioanna Skountzou
Influenza virus causes life-threatening infections in pregnant women and their newborns. Immunization during pregnancy is the most effective means of preventing maternal and infant mortality/morbidity; however, influenza vaccination rates of pregnant women remain under 50%. Furthermore, the availability of vaccines in low-resource populations is limited. Skin immunization with microneedle patches (MN) is a novel and safe vaccination platform featuring thermostable vaccine formulations. Cold-chain independence and the potential for self-administration can expand influenza vaccination coverage in developing countries...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720460/loss-of-chance-associated-with-sub-optimal-hpv-vaccination-coverage-rate-in-france
#18
Mathieu Uhart, Marjorie Adam, André Dahlab, Xavier Bresse
INTRODUCTION: Since 2007, HPV vaccination programs have been implemented in Europe. Significant real-life impact has already been reported in countries where the programs have been successfully implemented. In France, HPV vaccination coverage rate (VCR) is currently one of the lowest in Europe. This represents a missed opportunity for individuals who will not be protected. The study aimed to estimate the consequences of the sub-optimal VCR. METHODS: A dynamic transmission model was calibrated to the French setting...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720447/projected-impact-of-hpv-vaccination-and-primary-hpv-screening-on-cervical-adenocarcinoma-example-from-australia
#19
Megan A Smith, Karen Canfell
Cytology-based cervical screening appears to have had a limited effect on the incidence of adenocarcinoma, however HPV vaccination and HPV-based screening will likely play a role in reducing future burden. Using Australia as an example, we estimated the future burden (2015-2040) of adenocarcinoma in the absence of other interventions; and the impact of HPV vaccination (introduced 2007) and HPV-based screening (commencing 2017). Future burden was estimated considering underlying trends in adenocarcinoma, using national data (1982-2010)...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720445/moving-beyond-sex-assessing-the-impact-of-gender-identity-on-human-papillomavirus-vaccine-recommendations-and-uptake-among-a-national-sample-of-rural-residing-lgbt-young-adults
#20
Robert A Bednarczyk, Jennifer L Whitehead, Rob Stephenson
BACKGROUND: While national human papillomavirus (HPV) vaccination estimates exist by sex, little is known about HPV vaccination rates by gender identity. METHODS: We conducted a self-administered, anonymous online cross-sectional survey, with recruitment through Facebook ads, of lesbian, gay, bisexual, and transgender individuals in rural areas of the US. We compared HPV vaccine recommendation and uptake by self-reported sex assigned at birth and current gender identity...
June 2017: Papillomavirus Research
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