Hyun Woo Chung, Kyoung Sik Park, Ilhan Lim, Woo Chul Noh, Young Bum Yoo, Sang Eun Nam, Young So, Eun Jeong Lee
Breast cancer, with its global prevalence and impact on women's health, necessitates effective early detection and accurate staging for optimal patient outcomes. Traditional imaging modalities such as mammography, ultrasound, and dynamic contrast-enhanced magnetic resonance imaging (MRI) play crucial roles in local-regional assessment, while bone scintigraphy and 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) aid in evaluating distant metastasis. Despite the proven utility of 18 F-FDG PET/CT in various cancers, its limitations in breast cancer, such as high false-negative rates for small and low-grade tumors, have driven exploration into novel targets for PET radiotracers, including estrogen receptor, human epidermal growth factor receptor-2, fibroblast activation protein, and hypoxia...
January 12, 2024: Biomedicines