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Contrast enhanced breast imaging

Rüdiger Schulz-Wendtland, Caroline Preuss, Peter A Fasching, Christian R Loehberg, Michael P Lux, Julius Emons, Matthias W Beckmann, Michael Uder, Markus Mueller-Schimpfle
Introduction: For decades, conventional galactography was the only imaging technique capable of showing the mammary ducts. Today, diagnosis is based on a multimodal concept which combines high-resolution ultrasound with magnetic resonance (MR) mammography and ductoscopy/galactoscopy and has a sensitivity and specificity of up to 95%. This study used tomosynthesis in galactography for the first time and compared the synthetic digital 2D full-field mammograms generated with this technique with the images created using the established method of ductal sonography...
May 2018: Geburtshilfe und Frauenheilkunde
Marco Macchini, Martina Ponziani, Andrea Prochowski Iamurri, Mirco Pistelli, Mariagrazia De Lisa, Rossana Berardi, Gian Marco Giuseppetti
OBJECTIVE: The purpose of this retrospective study is to find a correlation between dynamic contrast-enhanced MR features with histological, immunohistochemical and loco-regional characteristics of breast cancer. MATERIALS AND METHODS: A total of 149 patients with histopathologically confirmed invasive breast carcinoma underwent MR imaging. Histological analysis included: histological features (histological type, necrosis, vascular invasion and Mib-1), immunohistochemical characterization (immunophenotype, receptor status, HER2-neu and grading) and loco-regional characteristics (T and N)...
June 5, 2018: La Radiologia Medica
Evanthia Kousi, Elizabeth A M O'Flynn, Marco Borri, Veronica A Morgan, Nandita M de Souza, Maria A Schmidt
PURPOSE: Baseline T2* relaxation time has been proposed as an imaging biomarker in cancer, in addition to Dynamic Contrast-Enhanced (DCE) MRI and diffusion-weighted imaging (DWI) parameters. The purpose of the current work is to investigate sources of error in T2* measurements and the relationship between T2* and DCE and DWI functional parameters in breast cancer. METHODS: Five female volunteers and thirty-two women with biopsy proven breast cancer were scanned at 3 T, with Research Ethics Committee approval...
May 31, 2018: Magnetic Resonance Imaging
Shinsuke Sasada, Norio Masumoto, Noriko Goda, Keiko Kajitani, Akiko Emi, Takayuki Kadoya, Morihito Okada
OBJECTIVES: To assess the factors causing tumor undetectability on ring-type dedicated breast positron emission tomography (DbPET). METHODS: A total of 265 patients (288 tumors) underwent DbPET and contrast-enhanced magnetic resonance imaging (MRI) in a prone position. The distance between the shallowest part of the breast tumor and the front end of the pectoralis major muscle on MRI was considered as the tumor-to-chest wall distance. RESULTS: Twenty-four tumors (8...
May 22, 2018: Clinical Imaging
Arwa A Alzaghal, Pamela J DiPiro
PURPOSE OF REVIEW: Advanced mammographic imaging modalities have been implemented in clinical practices throughout the USA. The most notable and widely used has been the three-dimensional derivative of digital mammography, known as digital breast tomosynthesis (DBT). In this article, we review the screening and diagnostic applications of DBT, along with its limitations. We also briefly address several supplemental breast imaging modalities. RECENT FINDINGS: The accumulating evidence from both small and large-scale trials has shown a significant reduction in recall rates and slight increase in cancer detection rates when using DBT...
May 29, 2018: Current Oncology Reports
Yongsik Jung, Seong Kyun Jeong, Doo Kyoung Kang, Yeorae Moon, Tae Hee Kim
OBJECTIVE: We quantitatively analyzed background parenchymal enhancement (BPE) in whole breast according to menstrual cycle and compared it with a qualitative analysis method. MATERIALS AND METHODS: A data set of breast magnetic resonance imaging (MRI) from 273 breast cancer patients was used. For quantitative analysis, we used semiautomated in-house software with MATLAB. From each voxel of whole breast, the software calculated BPE using following equation: [(signal intensity [SI] at 1 min 30 s after contrast injection - baseline SI)/baseline SI] × 100%...
June 2018: European Journal of Radiology
Depeng Wang, Dong Hyeun Lee, Haoyuan Huang, Tri Vu, Rachel Su Ann Lim, Nikhila Nyayapathi, Upendra Chitgupi, Maggie Liu, Jumin Geng, Jun Xia, Jonathan F Lovell
Photoacoustic computed tomography (PACT) is an emerging imaging modality. While many contrast agents have been developed for PACT, these typically cannot immediately be used in humans due to the lengthy regulatory process. We screened two hundred types of ingestible foodstuff samples for photoacoustic contrast with 1064 nm pulse laser excitation, and identified roasted barley as a promising candidate. Twenty brands of roasted barley were further screened to identify the one with the strongest contrast, presumably based on complex chemical modifications incurred during the roasting process...
May 17, 2018: Biomaterials
Joon Ho Choi, Ilhan Lim, Woo Chul Noh, Hyun-Ah Kim, Min-Ki Seong, Seonah Jang, Hyesil Seol, Hansol Moon, Byung Hyun Byun, Byung Il Kim, Chang Woon Choi, Sang Moo Lim
OBJECTIVE: The aim of this study is to assess tumor differentiation using parameters from sequential positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) in patients with breast cancer. METHODS: This retrospective study included 78 patients with breast cancer. All patients underwent sequential PET/CT and MRI. For fluorodeoxyglucose (FDG)-PET image analysis, the maximum standardized uptake value (SUVmax ) of FDG was assessed at both 1 and 2 h and metabolic tumor volume (MTV) and total lesion glycolysis (TLG)...
May 23, 2018: Annals of Nuclear Medicine
Mosa Alhamami, Weiran Cheng, Yuanyuan Lyu, Christine Allen, Xiao-An Zhang, Hai-Ling Margaret Cheng
Magnetic resonance imaging (MRI) contrast agents (CAs) are chemical compounds that can enhance image contrast on T1- or T2- weighted MR image. We have previously demonstrated the potential of MnCl2, a manganese-based CA, in cellular imaging of breast cancer using T1-weighted MRI. In this work, we examined the potential of another class of manganese-based CAs, manganese porphyrins (MnPs), for sensitive cellular detection of multiple clinical subtypes of breast cancer using quantitative MRI. Using a clinical 3...
2018: PloS One
Giuseppe Falco, Simone Mele, Maurizio Zizzo, Graziella Di Grezia, Paolo Cecinato, Giulia Besutti, Saverio Coiro, Gianluca Gatta, Rita Vacondio, Guglielmo Ferrari
INTRODUCTION: Metastatic spread in invasive lobular carcinoma (ILC) of breast mainly occurs in bones, gynecological organs, peritoneum, retroperitoneum, and gastrointestinal (GI) tract. Metastases to the GI tract may arise many years after initial diagnosis and can affect the tract from the tongue to the anus, stomach being the most commonly involved site. Clinical presentations are predominantly nonspecific, and rarely asymptomatic. CEA, CA 15-3, and CA 19-9 may be informative for symptomatic patients who have had a previous history of breast cancer...
May 2018: Medicine (Baltimore)
Johannes Uhlig, Annemarie Uhlig, Meike Kunze, Tim Beissbarth, Uwe Fischer, Joachim Lotz, Susanne Wienbeck
OBJECTIVE: The purpose of this study is to evaluate the diagnostic performance of machine learning techniques for malignancy prediction at breast cone-beam CT (CBCT) and to compare them to human readers. SUBJECTS AND METHODS: Five machine learning techniques, including random forests, back propagation neural networks (BPN), extreme learning machines, support vector machines, and K-nearest neighbors, were used to train diagnostic models on a clinical breast CBCT dataset with internal validation by repeated 10-fold cross-validation...
May 24, 2018: AJR. American Journal of Roentgenology
Cheng-Chuan Hu, Tsun-Hou Chang, Hsian-He Hsu, Yi-Jen Pen, Jyh-Cherng Yu
BACKGROUND Cholesterol granuloma is a benign condition that can be misdiagnosed as breast cancer on mammographic and ultrasound imaging. A case of concomitant cholesterol granuloma with invasive ductal carcinoma of the left breast was imaged with ultrasound elastography and magnetic resonance imaging (MRI) methods, including T1-weighted dynamic contrast-enhanced MRI (DCE-MRI), before biopsy and histopathology. CASE REPORT A 52-year-old woman, with a previous history of intraduct papillomas in both breasts, underwent six-monthly follow-up breast imaging...
May 23, 2018: American Journal of Case Reports
V Lehotska, K Rauova, L Vanovcanova
The aim was to analyze morphologico-functional characteristics of ductal carcinoma in situ (DCIS) in breast MRI to assess signs correlating with the degree of nuclear atypia. From 636 malignant lesions, 114 were DCIS (17.92%): 44 cases of high-grade (38.60%), 37 intermediate (32.45%), 33 low-grade (28.95%). MRI characteristics - T2 signal intensity (SI), shape, margins, contrast enhancement, peripheral/ductal enhancement, kinetic curve, presence of restriction of diffusion were correlated with the nuclear grade of DCIS...
March 14, 2018: Neoplasma
Bang-Bin Chen, Yen-Shen Lu, Chih-Wei Yu, Ching-Hung Lin, Tom Wei-Wu Chen, Shwu-Yuan Wei, Ann-Lii Cheng, Tiffany Ting-Fang Shih
OBJECTIVES: The aim of this study is to investigate the correlation of survival outcomes with imaging biomarkers from multiparametric magnetic resonance imaging (MRI) in patients with brain metastases from breast cancer (BMBC). METHODS: This study was approved by the institutional review board. Twenty-two patients with BMBC who underwent treatment involving bevacizumab on day 1, etoposide on days 2-4, and cisplatin on day 2 in 21-day cycles were prospectively enrolled for a phase II study...
May 16, 2018: European Radiology
Hideaki Ogata, Yukio Mitsuzuka, Naoko Honma, Miho Yoshida, Makoto Sumazaki, Fumi Saito, Masahiro Kobayashi, Kazutoshi Shibuya, Tetsuo Mikami, Hironori Kaneko
PURPOSE: Paget disease of the breast is a rare cancer that originates from the nipple-areolar complex. It is often overlooked and misdiagnosed as benign chronic eczema of the nipple. We aimed to retrospectively verify whether blood flow analysis using Doppler sonography was useful for detecting the presence of Paget disease. METHODS: In this retrospective study, 12 patients with pathologically proven unilateral nipple eczematous lesions (seven with Paget disease and five with simple dermatitis) were included...
2018: PloS One
John Dortch, Antonio J Forte, Candice Bolan, Pujan Kandel, Galen Perdikis
BACKGROUND: Venous congestion after deep inferior epigastric artery perforator (DIEP) flap breast reconstruction is a complication that may be partially attributable to variations in venous abdominal wall anatomy. In previous work, we have shown that ferumoxytol may be used as a bloodpool contrast agent to perform high-resolution venous imaging. Our current aim was to use this technology to perform a detailed analysis of the venous anatomy among patients undergoing DIEP flap breast reconstruction...
May 14, 2018: Annals of Plastic Surgery
Heather M Whitney, Nathan S Taylor, Karen Drukker, Alexandra V Edwards, John Papaioannou, David Schacht, Maryellen L Giger
RATIONALE AND OBJECTIVES: The objective of this study was to demonstrate improvement in distinguishing between benign lesions and luminal A breast cancers in a large clinical breast magnetic resonance imaging database by using quantitative radiomics over maximum linear size alone. MATERIALS AND METHODS: In this retrospective study, 212 benign lesions and 296 luminal A breast cancers were automatically segmented from dynamic contrast-enhanced breast magnetic resonance images...
May 10, 2018: Academic Radiology
Gopichandh Danala, Bhavika Patel, Faranak Aghaei, Morteza Heidari, Jing Li, Teresa Wu, Bin Zheng
Contrast-enhanced digital mammography (CEDM) is a promising imaging modality in breast cancer diagnosis. This study aims to investigate how to optimally develop a computer-aided diagnosis (CAD) scheme of CEDM images to classify breast masses. A CEDM dataset of 111 patients was assembled, which includes 33 benign and 78 malignant cases. Each CEDM includes two types of images namely, low energy (LE) and dual-energy subtracted (DES) images. A CAD scheme was applied to segment mass regions depicting on LE and DES images separately...
May 10, 2018: Annals of Biomedical Engineering
Beatrice Cavallo Marincola, Marianna Telesca, Fulvio Zaccagna, Frank Riemer, Michele Anzidei, Carlo Catalano, Federica Pediconi
Background The goals of neoadjuvant chemotherapy (NAC) are to reduce tumor volume and to offer a prognostic indicator in assessing treatment response. Contrast-enhanced magnetic resonance imaging (CE-MRI) is an established method for evaluating response to NAC in patients with breast cancer. Purpose To validate the role of unenhanced MRI (ue-MRI) compared to CE-MRI for assessing response to NAC in women with breast cancer. Material and Methods Seventy-one patients with ongoing NAC for breast cancer underwent MRI before, during, and at the end of NAC...
January 1, 2018: Acta Radiologica
Sibel Kul, Yavuz Metin, Musa Kul, Nurgul Metin, Ilker Eyuboglu, Oguzhan Ozdemir
BACKGROUND: Diffusion-weighted imaging (DWI) is a noncontrast-enhanced MRI technique. There are new promising studies on the use of DWI as a part of the enhanced or unenhanced abbreviated breast MRI protocols. PURPOSE: To evaluate the ability of breast DWI in the assessment of mass morphology and determine the contribution of this morphologic evaluation in their characterization. STUDY TYPE: Retrospective. POPULATION: In all, 213 consecutive women were breast MR imaged and had a later confirmed diagnosis...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
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