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Contrast enhanced breast imaging

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https://www.readbyqxmd.com/read/28226683/preliminary-imaging-results-and-sar-analysis-of-a-microwave-imaging-system-for-early-breast-cancer-detection
#1
Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ashkan Ghanbarzadeh Dagheyan, Ali Molaei, Richard Obermeier, Jose Martinez-Lorenzo, Ali Molaei, Ashkan Ghanbarzadeh Dagheyan, Jose Martinez-Lorenzo, Richard Obermeier
Currently X-ray-based imaging systems suffer from low contrast between malignant and healthy fibrous tissues in breast. Microwave Near-field Radar Imaging (NRI) shows a higher contrast between the aforementioned tissues and therefore can enhance tumor detection and diagnosis accuracy. In this work, we present the first imaging results of our developed NRI system that is equipped with a pair of Antipodal Vivaldi Antennas. We used a metal bearing ball immersed in oil as our object of interest, to keep the first measurement configuration simple...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28209330/role-of-magnetic-resonance-imaging-in-detection-of-pathologic-complete-remission-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy-a-meta-analysis
#2
REVIEW
Yan-Lin Gu, Si-Meng Pan, Jie Ren, Zhi-Xue Yang, Guo-Qin Jiang
Pathologic complete remission after neoadjuvant chemotherapy has a role in guiding the management of breast cancer. The present meta-analysis examined the accuracy of contrast-enhanced magnetic resonance imaging (CE-MRI) and diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting the response to neoadjuvant chemotherapy and compared CE-MRI with ultrasonography, mammography, and positron emission tomography/computed tomography (PET/CT). Medical subject heading terms and related keywords were searched to generate a compilation of eligible studies...
January 11, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28208155/pet-mr-in-invasive-ductal-breast-cancer-correlation-between-imaging-markers-and-histological-phenotype
#3
Onofrio Antonio Catalano, Gary Lloyd Horn, Alberto Signore, Carlo Iannace, Maria Lepore, Mark Vangel, Angelo Luongo, Marco Catalano, Constance Lehman, Marco Salvatore, Andrea Soricelli, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
BACKGROUND: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. METHODS: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28187012/preoperative-axillary-lymph-node-evaluation-in-breast-cancer-current-issues-and-literature-review
#4
Hee Young Choi, Minho Park, Mirinae Seo, Eunjee Song, So Youn Shin, Yu-Mee Sohn
Axillary lymph node (ALN) status is an important prognostic factor for overall breast cancer survival. In current clinical practice, ALN status is evaluated before surgery via multimodal imaging and physical examination. Mammography is typically suboptimal for complete ALN evaluation. Currently, ultrasonography is widely used to evaluate ALN status; nonetheless, results may vary according to operator. Ultrasonography is the primary imaging modality for evaluating ALN status. Other imaging modalities including contrast-enhanced magnetic resonance imaging, computed tomography, and positron emission tomography/computed tomography can play additional roles in axillary nodal staging...
February 9, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28181343/apparent-diffusion-coefficient-values-may-help-predict-which-mri-detected-high-risk-breast-lesions-will-upgrade-at-surgical-excision
#5
Safia Cheeney, Habib Rahbar, Brian N Dontchos, Sara H Javid, Mara H Rendi, Savannah C Partridge
PURPOSE: To investigate whether diffusion-weighted imaging (DWI) features could assist in determining which high-risk lesions identified on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and diagnosed on core needle biopsy (CNB) will upgrade to malignancy on surgical excision. MATERIALS AND METHODS: This Institutional Review Board (IRB)-approved prospective study included participants with MRI-detected Breast Imaging Reporting and Data System (BI-RADS) 4 or 5 lesions with high-risk pathology on CNB who underwent surgical excision...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28177554/identifying-relations-between-imaging-phenotypes-and-molecular-subtypes-of-breast-cancer-model-discovery-and-external-validation
#6
Jia Wu, Xiaoli Sun, Jeff Wang, Yi Cui, Fumi Kato, Hiroki Shirato, Debra M Ikeda, Ruijiang Li
PURPOSE: To determine whether dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) characteristics of the breast tumor and background parenchyma can distinguish molecular subtypes (ie, luminal A/B or basal) of breast cancer. MATERIALS AND METHODS: In all, 84 patients from one institution and 126 patients from The Cancer Genome Atlas (TCGA) were used for discovery and external validation, respectively. Thirty-five quantitative image features were extracted from DCE-MRI (1...
February 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28166261/radiomic-analysis-reveals-dce-mri-features-for-prediction-of-molecular-subtypes-of-breast-cancer
#7
Ming Fan, Hui Li, Shijian Wang, Bin Zheng, Juan Zhang, Lihua Li
The purpose of this study was to investigate the role of features derived from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and to incorporated clinical information to predict the molecular subtypes of breast cancer. In particular, 60 breast cancers with the following four molecular subtypes were analyzed: luminal A, luminal B, human epidermal growth factor receptor-2 (HER2)-over-expressing and basal-like. The breast region was segmented and the suspicious tumor was depicted on sequentially scanned MR images from each case...
2017: PloS One
https://www.readbyqxmd.com/read/28152264/prediction-of-malignancy-by-a-radiomic-signature-from-contrast-agent-free-diffusion-mri-in-suspicious-breast-lesions-found-on-screening-mammography
#8
Sebastian Bickelhaupt, Daniel Paech, Philipp Kickingereder, Franziska Steudle, Wolfgang Lederer, Heidi Daniel, Michael Götz, Nils Gählert, Diana Tichy, Manuel Wiesenfarth, Frederik B Laun, Klaus H Maier-Hein, Heinz-Peter Schlemmer, David Bonekamp
PURPOSE: To assess radiomics as a tool to determine how well lesions found suspicious on breast cancer screening X-ray mammography can be categorized into malignant and benign with unenhanced magnetic resonance (MR) mammography with diffusion-weighted imaging and T2 -weighted sequences. MATERIALS AND METHODS: From an asymptomatic screening cohort, 50 women with mammographically suspicious findings were examined with contrast-enhanced breast MRI (ceMRI) at 1.5T. Out of this protocol an unenhanced, abbreviated diffusion-weighted imaging protocol (ueMRI) including T2 -weighted, (T2 w), diffusion-weighted imaging (DWI), and DWI with background suppression (DWIBS) sequences and corresponding apparent diffusion coefficient (ADC) maps were extracted...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28150325/accuracy-of-contrast-enhanced-ultrasound-compared-with-magnetic-resonance-imaging-in-assessing-the-tumor-response-after-neoadjuvant-chemotherapy-for-breast-cancer
#9
Sandy C Lee, Edward Grant, Pulin Sheth, Agustin A Garcia, Bhushan Desai, Lingyun Ji, Susan Groshen, Darryl Hwang, Mary Yamashita, Linda Hovanessian-Larsen
OBJECTIVES: This pilot study compared contrast enhanced ultrasound (US) with contrast-enhanced magnetic resonance imaging (MRI) in assessing the treatment response in patients with breast cancer receiving preoperative neoadjuvant chemotherapy (NAC). METHODS: This prospective Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant study included 30 patients, from January 2014 to October 2015, with invasive breast cancer detected by mammography, conventional US imaging, or both and scheduled for NAC...
February 2, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28149923/investigation-of-x-ray-spectra-for-iodinated-contrast-enhanced-dedicated-breast-ct
#10
Stephen J Glick, Andrey Makeev
Screening for breast cancer with mammography has been very successful, resulting in part to a reduction of breast cancer mortality by approximately 39% since 1990. However, mammography still has limitations in performance, especially for women with dense breast tissue. Iodinated contrast-enhanced, dedicated breast CT (BCT) has been proposed to improve lesion analysis and the accuracy of diagnostic workup for patients suspected of having breast cancer. A mathematical analysis to explore the use of various x-ray filters for iodinated contrast-enhanced BCT is presented...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28142179/breast-mri-at-very-short-te-minte-image-analysis-of%C3%A2-minte-sequences-on-non-fat-saturated-subtracted-t1-weighted-images
#11
Evelyn Wenkel, Rolf Janka, Christian Geppert, Nadine Kaemmerer, Arndt Hartmann, Michael Uder, Matthias Hammon, Michael Brand
Purpose The aim was to evaluate a minimum echo time (minTE) protocol for breast magnetic resonance imaging (MRI) in patients with breast lesions compared to a standard TE (nTE) time protocol. Methods Breasts of 144 women were examined with a 1.5 Tesla MRI scanner. Additionally to the standard gradient-echo sequence with nTE (4.8 ms), a variant with minimum TE (1.2 ms) was used in an interleaved fashion which leads to a better temporal resolution and should reduce the scan time by approximately 50 %...
February 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28133745/technical-note-development-of-a-combined-molecular-breast-imaging-ultrasound-system-for-diagnostic-evaluation-of-mbi-detected-lesions
#12
Michael K O'Connor, Melissa M Morrow, Thuy Tran, Carrie B Hruska, Amy L Conners, Katie N Hunt
PURPOSE: The purpose of this study was to perform a pilot evaluation of an integrated molecular breast imaging/ultrasound (MBI/US) system designed to enable, in real-time, the registration of US to MBI and diagnostic evaluation of breast lesions detected on MBI. METHODS: The MBI/US system was constructed by modifying an existing dual-head cadmium zinc telluride (CZT)-based MBI gamma camera. The upper MBI detector head was replaced with a mesh panel, which allowed an ultrasound probe to access the breast...
December 9, 2016: Medical Physics
https://www.readbyqxmd.com/read/28133052/-intra-cystic-mucinous-carcinoma-of-the-breast-a-case-report
#13
Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Kenichi Sakurai, Makoto Makishima, Tsugumichi Koshinaga
A 75-year-old woman consulted our hospital for a lump on her left breast. The tumor was 5 cm in diameter and was palpable in the ABE area. The tumor was identified as an intra-cystic tumor using ultrasonography. Contrast-enhanced magnetic resonance imaging showed a tumor with cystic components that were slowly stained in a dynamic study. A fine needle aspiration biopsywas performed, and the pathological diagnosis was class V. Metastatic work-up revealed no evidence of metastasis. Therefore, we determined the clinical stage as T3N0M0, stage II B...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28112559/breast-radiation-dose-with-cesm-compared-with-2d-ffdm-and-3d-tomosynthesis-mammography
#14
COMPARATIVE STUDY
Judy R James, William Pavlicek, James A Hanson, Thomas F Boltz, Bhavika K Patel
OBJECTIVE: We aimed to compare radiation dose received during contrast-enhanced spectral mammography (CESM) using high- and low-energy projections with radiation dose received during 2D full field digital mammography (FFDM) and 3D tomosynthesis on phantoms and patients with varying breast thickness and density. MATERIALS AND METHODS: A single left craniocaudal projection was chosen to determine the doses for 6214 patients who underwent 2D FFDM, 3662 patients who underwent 3D tomosynthesis, and 173 patients who underwent CESM in this retrospective study...
February 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28106614/study-of-intrapatient-variability-and-reproducibility-of-quantitative-tumor-perfusion-parameters-evaluated-with-dynamic-contrast-enhanced-ultrasonography
#15
Nathalie Lassau, Bénédicte Coiffier, Laura Faivre, Baya Benatsou, Sophie Bidault, Elizabeth Girard, Bernard Asselain, Stéphanie Pitre-Champagnat, Serge Koscielny
OBJECTIVES: Dynamic contrast-enhanced (DCE) ultrasonography (US) is a functional imaging technique enabling quantitative assessment of solid tumor perfusion in metastatic patients treated with antiangiogenic therapies.The objective of this prospective single-center study was to evaluate in real-life conditions (in routine clinical practice) the intrapatient variability and reproducibility of DCE-US parameters. MATERIALS AND METHODS: Each patient provided written informed consent and had 2 DCE-US examinations (preprandial and postprandial) at baseline, day 15, and 1 month after treatment initiation...
March 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28102955/compound-speckle-model-detects-anti-angiogenic-tumor-response-in-preclinical-nonlinear-contrast-enhanced-ultrasonography
#16
Matthew R Lowerison, Justin J Tse, M Nicole Hague, Ann F Chambers, David W Holdsworth, James C Lacefield
PURPOSE: This paper proposes a method for analyzing the first-order speckle statistics of nonlinear contrast-enhanced ultrasound images from tumors. METHODS: Contrast signal intensity is modeled as a compound distribution of exponential probability density functions with a gamma weighting function. The gamma probability weighting function serves as an approximation for log-normally distributed flow velocities in a vascular network. The model was applied to sub-harmonic bolus-injection images acquired from a mouse breast cancer xenograft model treated with murine version bevacizumab...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28097214/location-and-lesion-dependent-estimation-of-mammographic-background-tissue-complexity
#17
Ali Avanaki, Kathryn Espig, Tom Kimpe
We specify a notion of perceived background tissue complexity (BTC) that varies with lesion shape, lesion size, and lesion location in the image. We propose four unsupervised BTC estimators based on: perceived pre and postlesion similarity of images, lesion border analysis (LBA; conspicuous lesion should be brighter than its surround), tissue anomaly detection, and local energy. The latter two are existing methods adapted for location- and lesion-dependent BTC estimation. For evaluation, we ask human observers to measure BTC (threshold visibility amplitude of a given lesion inserted) at specified locations in a mammogram...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28096667/hyaluronan-modified-superparamagnetic-iron-oxide-nanoparticles-for-bimodal-breast-cancer-imaging-and-photothermal-therapy
#18
Rui-Meng Yang, Chao-Ping Fu, Jin-Zhi Fang, Xiang-Dong Xu, Xin-Hua Wei, Wen-Jie Tang, Xin-Qing Jiang, Li-Ming Zhang
Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HA-SPIONs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28091804/baseline-results-from-the-uk-signify-study-a-whole-body-mri-screening-study-in-tp53-mutation-carriers-and-matched-controls
#19
Sibel Saya, Emma Killick, Sarah Thomas, Natalie Taylor, Elizabeth K Bancroft, Jeanette Rothwell, Sarah Benafif, Alexander Dias, Christos Mikropoulos, Jenny Pope, Anthony Chamberlain, Ranga Gunapala, Louise Izatt, Lucy Side, Lisa Walker, Susan Tomkins, Jackie Cook, Julian Barwell, Vicki Wiles, Lauren Limb, Diana Eccles, Martin O Leach, Susan Shanley, Fiona J Gilbert, Helen Hanson, David Gallagher, Bala Rajashanker, Richard W Whitehouse, Dow-Mu Koh, S Aslam Sohaib, D Gareth Evans, Rosalind A Eeles
In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to investigate the role of one-off non-contrast whole-body MRI (WB MRI) in the screening of asymptomatic TP53 mutation carriers. 44 TP53 mutation carriers and 44 population controls were recruited. Scans were read by radiologists blinded to participant carrier status. The incidence of malignancies diagnosed in TP53 mutation carriers against general population controls was calculated...
January 16, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28073839/unsupervised-clustering-of-quantitative-image-phenotypes-reveals-breast-cancer-subtypes-with-distinct-prognoses-and-molecular-pathways
#20
Jia Wu, Yi Cui, Xiaoli Sun, Guohong Cao, Bailiang Li, Debra M Ikeda, Allison W Kurian, Ruijiang Li
PURPOSE: To identify novel breast cancer subtypes by extracting quantitative imaging phenotypes of the tumor and surrounding parenchyma, and to elucidate the underlying biological underpinnings and evaluate the prognostic capacity for predicting recurrence-free survival (RFS). METHODS: We retrospectively analyzed dynamic contrast-enhanced magnetic resonance imaging data of patients from a single-center discovery cohort (n=60) and an independent multi-center validation cohort (n=96)...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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