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Contrast enhanced breast imaging

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https://www.readbyqxmd.com/read/28626876/optical-molecular-imaging-guided-radiation-therapy-part-2-integrated-x-ray-and-fluorescence-molecular-tomography
#1
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT guided irradiator to improve tumor localization for image guided radiation. METHODS: The FMT system was aligned orthogonal to the cone beam CT onboard our previously developed image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28623558/a-method-to-recognize-anatomical-site-and-image-acquisition-view-in-x-ray-images
#2
Xiao Chang, Thomas Mazur, H Harold Li, Deshan Yang
A method was developed to recognize anatomical site and image acquisition view automatically in 2D X-ray images that are used in image-guided radiation therapy. The purpose is to enable site and view dependent automation and optimization in the image processing tasks including 2D-2D image registration, 2D image contrast enhancement, and independent treatment site confirmation. The X-ray images for 180 patients of six disease sites (the brain, head-neck, breast, lung, abdomen, and pelvis) were included in this study with 30 patients each site and two images of orthogonal views each patient...
June 16, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28622412/textural-analysis-of-early-phase-spatiotemporal-changes-in-contrast-enhancement-of-breast-lesions-imaged-with-an-ultrafast-dce-mri-protocol
#3
Jana Milenković, Mehmet Ufuk Dalmış, Janez Žgajnar, Bram Platel
PURPOSE: New ultrafast view-sharing sequences have enabled breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to be performed at high spatial and temporal resolution. The aim of this study is to evaluate the diagnostic potential of textural features that quantify the spatiotemporal changes of the contrast-agent uptake in computer-aided diagnosis of malignant and benign breast lesions imaged with high spatial and temporal resolution DCE-MRI. METHOD: The proposed approach is based on the textural analysis quantifying the spatial variation of six dynamic features of the early-phase contrast-agent uptake of a lesion's largest cross-sectional area...
June 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28609204/surveillance-of-women-with-the-brca1-or-brca2-mutation-by-using-biannual-automated-breast-us-mr-imaging-and-mammography
#4
Jan C M van Zelst, Roel D M Mus, Gwendolyn Woldringh, Matthieu J C M Rutten, Peter Bult, Suzan Vreemann, Mathijn de Jong, Nico Karssemeijer, Nicoline Hoogerbrugge, Ritse M Mann
Purpose To evaluate a multimodal surveillance regimen including yearly full-field digital (FFD) mammography, dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging, and biannual automated breast (AB) ultrasonography (US) in women with BRCA1 and BRCA2 mutations. Materials and Methods This prospective multicenter trial enrolled 296 carriers of the BRCA mutation (153 BRCA1 and 128 BRCA2 carriers, and 15 women with first-degree untested relatives) between September 2010 and November 2012, with follow-up until November 2015...
June 13, 2017: Radiology
https://www.readbyqxmd.com/read/28593433/additional-value-of-diffusion-weighted-imaging-to-evaluate-multifocal-and-multicentric-breast-cancer-detected-using-pre-operative-breast-mri
#5
Sung Eun Song, Eun Kyung Park, Kyu Ran Cho, Bo Kyoung Seo, Ok Hee Woo, Seung Pil Jung, Sung Bum Cho
OBJECTIVES: To investigate whether diffusion-weighted imaging (DWI) aids pre-operative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate additional lesions in breast cancer patients. METHODS: DCE-MRI and DWI were performed on 131 lesions, with available histopathological results. The apparent diffusion coefficient (ADC) of each lesion was measured, and the cut-off value for differentiation between malignant and benign lesions was calculated...
June 7, 2017: European Radiology
https://www.readbyqxmd.com/read/28583458/xanthomatous-hypophysitis-presenting-with-diabetes-insipidus-completely-cured-through-transsphenoidal-surgery-a-case-report-and-literature-review
#6
Wei Lin, Lu Gao, Xiaopeng Guo, Wenze Wang, Bing Xing
BACKGROUND: Xanthomatous hypophysitis (XH) is extremely rare. Only 27 cases have been reported in the literature. No XH patient presenting with diabetes insipidus (DI) has been completely cured through surgery. Here, we describe the first XH case of a DI patient whose pituitary function was normalized postoperatively, without hormone replacement therapy. CASE DESCRIPTION: A 41-year-old woman suffered from polydipsia, DI, headache and breast discharge. Laboratory investigation revealed hyperprolactinemia...
June 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28577335/application-of-whole-lesion-histogram-analysis-of-pharmacokinetic-parameters-in-dynamic-contrast-enhanced-mri-of-breast-lesions-with-the-caipirinha-dixon-twist-vibe-technique
#7
Zhiwei Li, Tao Ai, Yiqi Hu, Xu Yan, Marcel Dominik Nickel, Xiao Xu, Liming Xia
PURPOSE: To investigate the application of whole-lesion histogram analysis of pharmacokinetic parameters for differentiating malignant from benign breast lesions on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). MATERIALS AND METHODS: In all, 92 women with 97 breast lesions (26 benign and 71 malignant lesions) were enrolled in this study. Patients underwent dynamic breast MRI at 3T using a prototypical CAIPIRINHA-Dixon-TWIST-VIBE (CDT-VIBE) sequence and a subsequent surgery or biopsy...
June 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28570680/the-correlation-between-her-2-expression-and-the-ceus-and-arfi-characteristics-of-breast-cancer
#8
Xiao-Yan Wang, Qiao Hu, Meng-Yuan Fang, Yan He, Hai-Ming Wei, Xue-Xue Chen, Bing Zhang
OBJECTIVE: The purpose of the present study was to explore the correlation between the contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) characteristics of breast cancers and the expression of human epidermal growth factor receptor 2 (HER-2). METHODS: HER-2 expression levels in the tumor masses of 167 clearly diagnosed cases of breast cancer were measured and analyzed. The enhancement features and time intensity curve (TIC) of CEUS and virtual touch tissue imaging (VTI) and virtual touch tissue quantification (VTQ) technology of ARFI were employed to analyze the relationship between HER-2 expression and the CEUS and ARFI characteristics of breast cancer...
2017: PloS One
https://www.readbyqxmd.com/read/28567545/host-genetic-modifiers-of-nonproductive-angiogenesis-inhibit-breast-cancer
#9
Michael J Flister, Shirng-Wern Tsaih, Alexander Stoddard, Cody Plasterer, Jaidip Jagtap, Abdul K Parchur, Gayatri Sharma, Anthony R Prisco, Angela Lemke, Dana Murphy, Mona Al-Gizawiy, Michael Straza, Sophia Ran, Aron M Geurts, Melinda R Dwinell, Andrew S Greene, Carmen Bergom, Peter S LaViolette, Amit Joshi
PURPOSE: Multiple aspects of the tumor microenvironment (TME) impact breast cancer, yet the genetic modifiers of the TME are largely unknown, including those that modify tumor vascular formation and function. METHODS: To discover host TME modifiers, we developed a system called the Consomic/Congenic Xenograft Model (CXM). In CXM, human breast cancer cells are orthotopically implanted into genetically engineered consomic xenograft host strains that are derived from two parental strains with different susceptibilities to breast cancer...
May 31, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28563903/high-contrast-fluorescence-detection-of-metastatic-breast-cancer-including-bone-and-liver-micrometastases-via-size-controlled-ph-activatable-water-soluble-probes
#10
Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Kejin Zhou, Yihong Wan, Daniel J Siegwart
Breast cancer metastasis is the major cause of cancer death in women worldwide. Early detection would save many lives, but current fluorescence imaging probes are limited in their detection ability, particularly of bone and liver micrometastases. Herein, probes that are capable of imaging tiny (<1 mm) micrometastases in the liver, lung, pancreas, kidneys, and bone, that have disseminated from the primary site, are reported. The influence of the poly(ethylene glycol) (PEG) chain length on the performance of water-soluble, pH-responsive, near-infrared 4,4'-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) probes is systematically investigated to demonstrate that PEG tuning can provide control over micrometastasis tracking with high tumor-to-background contrast (up to 12/1)...
May 31, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28556576/ultrafast-dynamic-contrast-enhanced-mri-of-the-breast-using-compressed-sensing-breast-cancer-diagnosis-based-on-separate-visualization-of-breast-arteries-and-veins
#11
Natsuko Onishi, Masako Kataoka, Shotaro Kanao, Hajime Sagawa, Mami Iima, Marcel Dominik Nickel, Masakazu Toi, Kaori Togashi
PURPOSE: To evaluate the feasibility of ultrafast dynamic contrast-enhanced (UF-DCE) magnetic resonance imaging (MRI) with compressed sensing (CS) for the separate identification of breast arteries/veins and perform temporal evaluations of breast arteries and veins with a focus on the association with ipsilateral cancers. MATERIALS AND METHODS: Our Institutional Review Board approved this study with retrospective design. Twenty-five female patients who underwent UF-DCE MRI at 3T were included...
May 28, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28552888/cylindrical-inversion-pulse-for-the-reduction-of-cardiac-motion-artifacts-in-contrast-enhanced-breast-mri
#12
Masami Yoneyama, Masanobu Nakamura, Yuriko Ozawa, Makoto Obara, Tomoyuki Okuaki, Satoshi Tatsuno, Ryuji Sashi, Seishi Sawano, Marc Van Cauteren
We proposed a simple technique for reduction of cardiac-related motion artifacts on contrast-enhanced images in the breast by using cylindrical regional-suppression technique (CREST) that can directly suppress the heart signals. The purpose of this study was to select the optimal scan parameters and to evaluate the feasibility in the breast. We demonstrated that the optimized CREST could dramatically reduce the cardiac-related flow artifacts without any penalty to the acquisition time, signal-to-noise ratio and contrast-enhanced lesion-to-parenchyma contrast...
May 29, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28549292/globally-supported-radial-basis-function-based-collocation-method-for-evolution-of-level-set-in-mass-segmentation-using-mammograms
#13
Kanchan Lata Kashyap, Manish Kumar Bajpai, Pritee Khanna
Computer-aided detection systems play an important role for the detection of breast abnormalities using mammograms. Global segmentation of mass in mammograms is a complex process due to low contrast mammogram images, irregular shape of mass, speculated margins, and the presence of intensity variations of pixels. This work presents a new approach for mass detection in mammograms, which is based on the variational level set function. Mesh-free based radial basis function (RBF) collocation approach is employed for the evolution of level set function for segmentation of breast as well as suspicious mass region...
May 15, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28544159/simultaneous-measurement-of-t1-b1-and-pharmacokinetic-model-parameters-using-active-contrast-encoding-ace-mri
#14
Jin Zhang, Kerryanne Winters, Olivier Reynaud, Sungheon Gene Kim
The aim of this study was to assess the feasibility of combining dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with the measurement of the radiofrequency (RF) transmit field B1 and pre-contrast longitudinal relaxation time T10 . A novel approach has been proposed to simultaneously estimate B1 and T10 from a modified DCE-MRI scan that actively encodes the washout phase of the curve with different amounts of T1 and B1 weighting using multiple flip angles and repetition times, hence referred to as active contrast encoding (ACE)-MRI...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543761/experimental-characterization-of-a-direct-conversion-amorphous-selenium-detector-with-thicker-conversion-layer-for-dual-energy-contrast-enhanced-breast-imaging
#15
David A Scadutom, Olivier Tousignant, Wei Zhao
PURPOSE: Dual-energy contrast-enhanced imaging is being investigated as a tool to identify and localize angiogenesis in the breast, a possible indicator of malignant tumors. This imaging technique requires that x-ray images are acquired at energies above the k-shell binding energy of an appropriate radiocontrast agent. Iodinated contrast agents are commonly used for vascular imaging, and require x-ray energies greater than 33 keV. Conventional direct conversion amorphous selenium (a-Se) flat panel imagers for digital mammography show suboptimal absorption efficiencies at these higher energies...
May 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28541197/high-energy-resolution-hyperspectral-x-ray-imaging-for-low-dose-contrast-enhanced-digital-mammography
#16
Silvia Pani, Sarene Saifuddin, Filipa Ferreira, Nicholas Henthorn, Paul Seller, Paul Sellin, Philipp Stratmann, Matthew Veale, Matthew Wilson, Robert Cernik
Contrast-enhanced digital mammography (CEDM) is an alternative to conventional X-ray mammography for imaging dense breasts. However, conventional approaches to CEDM require a double exposure of the patient, implying higher dose and risk of incorrect image registration due to motion artifacts. A novel approach is presented, based on hyperspectral imaging, where a detector combining positional and high-resolution spectral information (in this case based on Cadmium Telluride) is used. This allows simultaneous acquisition of the two images required for CEDM...
May 18, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28533803/use-of-ultrasound-in-image-guided-high-dose-rate-brachytherapy-enumerations-and-arguments
#17
REVIEW
Susovan Banerjee, Tejinder Kataria, Deepak Gupta, Shikha Goyal, Shyam Singh Bisht, Trinanjan Basu, Ashu Abhishek
Inherently, brachytherapy is the most conformal radiotherapeutic technique. As an aid to brachytherapy, ultrasonography (USG) serves as a portable, inexpensive, and simple to use method allowing for accurate, reproducible, and adaptive treatments. Some newer brachytherapy planning systems have incorporated USG as the sole imaging modality. Ultrasonography has been successfully used to place applicator and dose planning for prostate, cervix, and anal canal cancers. It can guide placement of brachytherapy catheters for all other sites like breast, skin, and head and neck cancers...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28524656/multifunctional-and-redox-responsive-self-assembled-magnetic-nanovectors-for-protein-delivery-and-dual-modal-imaging
#18
Hong Yu Yang, Moon-Sun Jang, Yi Li, Jung Hee Lee, Doo Sung Lee
Nanoparticle (NP) based model carriers present an emerging strategy for protein delivery. However, constructing a multifunctional nanocarrier with high loading capacity, diagnostic imaging capacity, and controlled release capability is a tremendous challenge for protein delivery systems. Thus, we herein report on the fabrication of redox-responsive magnetic nanovectors (termed RMNs) through self- assembly of Fe3O4 NPs and redox-responsive polymer ligands, which could effectively transport protein and trigger intracellular protein release...
June 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28522877/dce-mri-background-parenchymal-enhancement-quantified-from-an-early-versus-delayed-post-contrast-sequence-association-with-breast-cancer-presence
#19
Shandong Wu, Margarita L Zuley, Wendie A Berg, Brenda F Kurland, Rachel C Jankowitz, Jules H Sumkin, David Gur
We investigated automated quantitative measures of background parenchymal enhancement (BPE) derived from an early versus delayed post-contrast sequence in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for association with breast cancer presence in a case-control study. DCE-MRIs were retrospectively analyzed for 51 cancer cases and 51 controls with biopsy-proven benign lesions, matched by age and year-of-MRI. BPE was quantified using fully-automated validated computer algorithms, separately from three sequential DCE-MRI post-contrast-subtracted sequences (SUB1, SUB2, and SUB3)...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521821/intratumoral-and-peritumoral-radiomics-for-the-pretreatment-prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-based-on-breast-dce-mri
#20
Nathaniel M Braman, Maryam Etesami, Prateek Prasanna, Christina Dubchuk, Hannah Gilmore, Pallavi Tiwari, Donna Pletcha, Anant Madabhushi
BACKGROUND: In this study, we evaluated the ability of radiomic textural analysis of intratumoral and peritumoral regions on pretreatment breast cancer dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to predict pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). METHODS: A total of 117 patients who had received NAC were retrospectively analyzed. Within the intratumoral and peritumoral regions of T1-weighted contrast-enhanced MRI scans, a total of 99 radiomic textural features were computed at multiple phases...
May 18, 2017: Breast Cancer Research: BCR
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