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Contrast enhanced breast imaging

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https://www.readbyqxmd.com/read/28708462/heterogeneous-enhancement-patterns-of-tumor-adjacent-parenchyma-at-mr-imaging-are-associated-with-dysregulated-signaling-pathways-and-poor-survival-in-breast-cancer
#1
Jia Wu, Bailiang Li, Xiaoli Sun, Guohong Cao, Daniel L Rubin, Sandy Napel, Debra M Ikeda, Allison W Kurian, Ruijiang Li
Purpose To identify the molecular basis of quantitative imaging characteristics of tumor-adjacent parenchyma at dynamic contrast material-enhanced magnetic resonance (MR) imaging and to evaluate their prognostic value in breast cancer. Materials and Methods In this institutional review board-approved, HIPAA-compliant study, 10 quantitative imaging features depicting tumor-adjacent parenchymal enhancement patterns were extracted and screened for prognostic features in a discovery cohort of 60 patients. By using data from The Cancer Genome Atlas (TCGA), a radiogenomic map for the tumor-adjacent parenchymal tissue was created and molecular pathways associated with prognostic parenchymal imaging features were identified...
July 14, 2017: Radiology
https://www.readbyqxmd.com/read/28691102/dce-mri-texture-features-for-early-prediction-of-breast-cancer-therapy-response
#2
Guillaume Thibault, Alina Tudorica, Aneela Afzal, Stephen Y-C Chui, Arpana Naik, Megan L Troxell, Kathleen A Kemmer, Karen Y Oh, Nicole Roy, Neda Jafarian, Megan L Holtorf, Wei Huang, Xubo Song
This study investigates the effectiveness of hundreds of texture features extracted from voxel-based dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parametric maps for early prediction of breast cancer response to neoadjuvant chemotherapy (NAC). In total, 38 patients with breast cancer underwent DCE-MRI before (baseline) and after the first of the 6-8 NAC cycles. Quantitative pharmacokinetic (PK) parameters and semiquantitative metrics were estimated from DCE-MRI time-course data. The residual cancer burden (RCB) index value was computed based on pathological analysis of surgical specimens after NAC completion...
March 2017: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/28690116/evaluating-pathologic-response-of-breast-cancer-to-neoadjuvant-chemotherapy-with-computer-extracted-features-from-contrast-enhanced-ultrasound-videos
#3
Qi Zhang, Congcong Yuan, Wei Dai, Lei Tang, Jun Shi, Zuoyong Li, Man Chen
PURPOSE: To extract quantitative perfusion and texture features with computer assistance from contrast-enhanced ultrasound (CEUS) videos of breast cancer before and after neoadjuvant chemotherapy (NAC), and to evaluate pathologic response to NAC with these features. METHODS: Forty-two CEUS videos with 140,484 images were acquired from 21 breast cancer patients pre- and post-NAC. Time-intensity curve (TIC) features were calculated including the difference between area under TIC within a tumor and that within a computer-detected reference region (AUT_T-R)...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28688583/image-improvement-method-for-positron-emission-mammography
#4
Nikolai V Slavine, Stephen J Seiler, Roderick W McColl, Robert E Lenkinski
PURPOSE: To evaluate in clinical use a rapidly converging, efficient iterative deconvolution algorithm (RSEMD) for improving the quantitative accuracy of previously reconstructed breast images by a commercial positron emission mammography (PEM) scanner. MATERIALS AND METHODS: The RSEMD method was tested on imaging data from clinical Naviscan Flex Solo II PEM scanner. This method was applied to anthropomorphic like breast phantom data and patient breast images previously reconstructed with Naviscan software to determine improvements in image resolution, signal to noise ratio (SNR) and contrast to noise ratio (CNR)...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28685676/recent-advances-in-superparamagnetic-iron-oxide-based-nanoprobes-as-multifunctional-theranostic-agents-for-breast-cancer-imaging-and-therapy
#5
Jianjun Zheng, Wenzhi Ren, Tianxiang Chen, Jin Yinhua, Aijing Li, Kun Yan, Yijiao Wu, Aiguo Wu
Breast cancer accounts for nearly one in three cancers, and it is the most common cancer diagnosed among women. The death rate of breast cancer is estimated to 14%. Hence, accurate diagnosis in early stage and effective treatment in any stage are critical for the survival of breast cancer. Mammogram has been the most common technique administered to detect breast cancer. However, the radiation dose from mammogram is harmful to patients. Fortunately, magnetic resonance imaging (MRI) can diagnose breast cancer without any radiation dose, and enhanced MRI can make earlier and differential diagnosis...
July 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28683503/focal-breast-lesions-in-clinical-ct-examinations-of-the-chest-a-retrospective-analysis
#6
Kathrin Barbara Krug, Christian Houbois, Olga Grinstein, Jan Borggrefe, Michael Puesken, Bettina Hanstein, Wolfram Malter, David Maintz, Martin Hellmich
Purpose Based on radiological reports, the percentage of breast cancers visualized as incidental findings in routine CT examinations is estimated at ≤ 2 %. In view of the rising number of CT examinations and the high prevalence of breast cancer, it was the goal of the present study to verify the frequency and image morphology of false-negative senological CT findings. Materials and Methods All first contrast-enhanced CT examinations of the chest in adult female patients carried out in 2012 were retrospectively included...
July 6, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28681390/a-deep-feature-fusion-methodology-for-breast-cancer-diagnosis-demonstrated-on-three-imaging-modality-datasets
#7
Natalia Antropova, Benjamin Q Huynh, Maryellen L Giger
Deep learning methods for radiomics/computer-aided diagnosis (CADx) are often prohibited by small datasets, long computation time, and the need for extensive image preprocessing. We present a methodology that extracts and pools low- to mid-level features using a pre-trained convolutional neural network and fuses them with handcrafted radiomic features computed using conventional CADx methods. Our fusion-based method demonstrates significant improvements to previous breast cancer CADx methods across three clinical imaging modalities (dynamic contrast-enhanced MRI, full-field digital mammography, and ultrasound) in terms of predictive performance in the task of estimating lesion malignancy...
July 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28679773/bevacizumab-induces-acute-hypoxia-and-cancer-progression-in-patients-with-refractory-breast-cancer-multimodal-functional-imaging-and-multiplex-cytokine-analysis
#8
Shigeto Ueda, Toshiaki Saeki, Akihiko Osaki, Tomohiko Yamane, Ichiei Kuji
Bevacizumab, an antibody against endothelial growth factor, is a key but controversial drug in the treatment of metastatic breast cancer. We, therefore, aimed to determine the intrinsic resistance to bevacizumab at the physiological and molecular levels in advanced breast cancer using positron emission tomography (PET), dynamic contrast-enhanced MRI, diffuse optical spectroscopic imaging (DOSI), and multiplex cytokine assays.<br />Experimental Design: In total, 28 patients diagnosed with stage III/IV advanced breast cancer receiving single-agent bevacizumab for 1 week followed by paclitaxel combined with bevacizumab underwent (18)F-fluorodeoxyglucose (FDG)-PET, (18)F-fluoromisonidazole (FMISO)-PET, and MRI at both baseline and two courses after treatment initiation...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28678022/eigentumors-for-prediction-of-treatment-failure-in-patients-with-early-stage-breast-cancer-using-dynamic-contrast-enhanced-mri-a-feasibility-study
#9
Hui Shan M Chan, Bas H M van der Velden, Claudette E Loo, Kenneth G A Gilhuijs
We present a radiomics model to discriminate between patients at low risk and those at high risk of treatment failure at long-term follow-up based on eigentumors: principal components computed from volumes encompassing tumors in washin and washout images of pre-treatment dynamic contrast-enhanced (DCE-) MR images. Eigentumors were computed from the images of 563 patients from the MARGINS study. Subsequently, a least absolute shrinkage selection operator (LASSO) selected candidates from the components that contained 90% of the variance of the data...
July 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28675570/predicting-the-level-of-tumor-infiltrating-lymphocytes-in-patients-with-triple-negative-breast-cancer-usefulness-of-breast-mri-computer-aided-detection-and-diagnosis
#10
You Jin Ku, Hak Hee Kim, Joo Hee Cha, Hee Jung Shin, Eun Young Chae, Woo Jung Choi, Hee Jin Lee, Gyungyub Gong
PURPOSE: To evaluate the usefulness of magnetic resonance imaging (MRI) computer-aided detection and diagnosis (CAD) for the detection of tumor-infiltrating lymphocytes (TILs) in triple-negative breast cancer (TNBC) patients. TNBC is a heterogeneous malignancy with a varying prognosis. Recently, the importance of TILs in TNBC has been determined. MATERIALS AND METHODS: We retrospectively enrolled 60 lesions of TNBC. Either at 1.5T or 3T MRI, including T1 , T2 -weighted, and dynamic contrast-enhanced, images were obtained...
July 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28667313/nanoparticles-for-live-cell-microscopy-a-surface-enhanced-raman-scattering-perspective
#11
Maria Navas-Moreno, Majid Mehrpouyan, Tatyana Chernenko, Demet Candas, Ming Fan, Jian Jian Li, Ming Yan, James W Chan
Surface enhanced Raman scattering (SERS) nanoparticles are an attractive alternative to fluorescent probes for biological labeling because of their photostability and multiplexing capabilities. However, nanoparticle size, shape, and surface properties are known to affect nanoparticle-cell interactions. Other issues such as the formation of a protein corona and antibody multivalency interfere with the labeling properties of nanoparticle-antibody conjugates. Hence, it is important to consider these aspects in order to validate such conjugates for live cell imaging applications...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666767/towards-breast-cancer-rotational-radiotherapy-with-synchrotron-radiation
#12
Francesca Di Lillo, Giovanni Mettivier, Antonio Sarno, Roberta Castriconi, Paolo Russo
PURPOSE: We performed the first investigations, via measurements and Monte Carlo simulations on phantoms, of the feasibility of a new technique for synchrotron radiation rotational radiotherapy for breast cancer (SR(3)T). METHODS: A Monte Carlo (MC) code based on Geant4 toolkit was developed in order to simulate the irradiation with the SR(3)T technique and to evaluate the skin sparing effect in terms of centre-to-periphery dose ratio at different energies in the range 60-175keV...
June 27, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28662390/targeting-property-and-toxicity-of-a-novel-ultrasound-contrast-agent-microbubble-carrying-the-targeting-and-drug-loaded-complex-fa-cnts-ptx-on-mcf7-cells
#13
Jie Zhang, Yu Zhang, Junxi Liu, Guozhong Li, Zhaohui Wen, Yue Zhao, Xiangyu Zhang, Fenghua Liu
The application of ultrasound contrast agents not only is confined to the enhancement of ultrasound imaging but also has started to be used as a drug system for diagnosis and treatment. In this paper, Span60 and PEG1500 were used as membrane materials, and a new targeting and drug-loading multifunctional ultrasound contrast agent microbubble enveloping the FA-CNTs-PTX complex was successfully prepared by acoustic cavitation. With the breast cancer cell line MCF7 as the research target, the effects of the microbubble with FA-CNTs-PTX on the proliferation and toxicity of MCF7 cells were studied using a CCK-8 and AO/EB double-staining method...
June 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28656751/gadolinium-labeled-biodegradable-dendron-hyaluronic-acid-hybrid-and-its-subsequent-application-as-a-safe-and-efficient-magnetic-resonance-imaging-contrast-agent
#14
Chunhua Guo, Ling Sun, Hao Cai, Zhenyu Duan, Shiyong Zhang, Qiyong Gong, Kui Luo, Zhongwei Gu
Novel magnetic resonance imaging (MRI) contrast agents with high sensitivity and good biocompatibility are required for the diagnosis of cancer. Herein, we prepared and characterized the gadolinium [Gd(III)]-labeled peptide dendron-hyaluronic acid (HA) conjugate-based hybrid (dendronized-HA-DOTA-Gd) by combining the advantages of HA and the peptide dendron. The dendronized-HA-DOTA-Gd hybrid with 3.8% Gd(III) as weight percentage showed a negative zeta potential (-35 mV). The in vitro degradation results indicated that the dendronized-HA-DOTA-Gd hybrid degraded into products with low molecular weights in the presence of hyaluronidase...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28656455/malignancy-detection-on-mammography-using-dual-deep-convolutional-neural-networks-and-genetically-discovered-false-color-input-enhancement
#15
Philip Teare, Michael Fishman, Oshra Benzaquen, Eyal Toledano, Eldad Elnekave
Breast cancer is the most prevalent malignancy in the US and the third highest cause of cancer-related mortality worldwide. Regular mammography screening has been attributed with doubling the rate of early cancer detection over the past three decades, yet estimates of mammographic accuracy in the hands of experienced radiologists remain suboptimal with sensitivity ranging from 62 to 87% and specificity from 75 to 91%. Advances in machine learning (ML) in recent years have demonstrated capabilities of image analysis which often surpass those of human observers...
June 27, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28654337/newly-diagnosed-breast-cancer-comparison-of-contrast-enhanced-spectral-mammography-and-breast-mr-imaging-in-the-evaluation-of-extent-of-disease
#16
Stephanie A Lee-Felker, Leena Tekchandani, Mariam Thomas, Esha Gupta, Denise Andrews-Tang, Antoinette Roth, James Sayre, Guita Rahbar
Purpose To compare the diagnostic performances of contrast material-enhanced spectral mammography and breast magnetic resonance (MR) imaging in the detection of index and secondary cancers in women with newly diagnosed breast cancer by using histologic or imaging follow-up as the standard of reference. Materials and Methods This institutional review board-approved, HIPAA-compliant, retrospective study included 52 women who underwent breast MR imaging and contrast-enhanced spectral mammography for newly diagnosed unilateral breast cancer between March 2014 and October 2015...
June 26, 2017: Radiology
https://www.readbyqxmd.com/read/28647387/practical-considerations-for-the-use-of-breast-mri-for-breast-cancer-evaluation-in-the-preoperative-setting
#17
Debra L Monticciolo
Preoperative contrast-enhanced (CE) breast magnetic resonance imaging (MRI) remains controversial in the newly diagnosed breast cancer patient. Additional lesions are frequently discovered in these patients with CE breast MRI. As staging and treatment planning evolve to include more information on tumor biology and aggression, so should our consideration of extent of disease. Directing CE breast MRI to those patients most likely to have additional disease may be beneficial. We sought to develop practical guidance for the use of preoperative CE breast MRI in the newly diagnosed breast cancer patient based on recent scientific data...
June 21, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28639300/multiparametric-mri-of-the-breast-a-review
#18
REVIEW
Maria Adele Marino, Thomas Helbich, Pascal Baltzer, Katja Pinker-Domenig
During their development, cancers acquire several functional capabilities, which are defined as the hallmarks of cancer. For a deeper understanding of the hallmarks of cancer, and, consequently, improved personalized patient care, diagnostic tests must be multilayered and complex to identify the relevant underlying processes of cancer development and progression. In this context, magnetic resonance imaging (MRI) has emerged as an exceptionally powerful, versatile, and precise imaging technique. MRI of the breast is an essential tool in breast imaging, with multiple indications...
June 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28626876/optical-molecular-imaging-guided-radiation-therapy-part-2-integrated-x-ray-and-fluorescence-molecular-tomography
#19
Junwei Shi, Thirupandiyur S Udayakumar, Zhiqun Wang, Nesrin Dogan, Alan Pollack, Yidong Yang
PURPOSE: Differentiating tumor from its surrounding soft tissues is challenging for x-ray computed tomography (CT). Fluorescence molecular tomography (FMT) can directly localize the internal tumors targeted with specific fluorescent probes. A FMT system was developed and integrated onto a CT guided irradiator to improve tumor localization for image guided radiation. METHODS: The FMT system was aligned orthogonal to the cone beam CT onboard our previously developed image guided small animal arc radiation treatment system (iSMAART)...
June 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28623558/a-method-to-recognize-anatomical-site-and-image-acquisition-view-in-x-ray-images
#20
Xiao Chang, Thomas Mazur, H Harold Li, Deshan Yang
A method was developed to recognize anatomical site and image acquisition view automatically in 2D X-ray images that are used in image-guided radiation therapy. The purpose is to enable site and view dependent automation and optimization in the image processing tasks including 2D-2D image registration, 2D image contrast enhancement, and independent treatment site confirmation. The X-ray images for 180 patients of six disease sites (the brain, head-neck, breast, lung, abdomen, and pelvis) were included in this study with 30 patients each site and two images of orthogonal views each patient...
June 16, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
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