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Contrast enhanced breast imaging

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https://www.readbyqxmd.com/read/29471620/augmented-reality-for-breast-imaging
#1
Alberto Rancati, Claudio Angrigiani, Maurizio B Nava, Giuseppe Catanuto, Nicola Rocco, Fernando Ventrice, Julio Dorr
BACKGROUND: Augmented reality (AR) enables the superimposition of virtual reality reconstructions onto clinical images of a real patient, in real time. This allows visualization of internal structures through overlying tissues, thereby providing a virtual transparency vision of surgical anatomy. AR has been applied to neurosurgery, which utilizes a relatively fixed space, frames, and bony references; the application of AR facilitates the relationship between virtual and real data. Augmented Breast imaging (ABI) is described...
February 21, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29464004/biomimetic-nanoparticles-with-enhanced-affinity-towards-activated-endothelium-as-versatile-tools-for-theranostic-drug-delivery
#2
Jonathan O Martinez, Roberto Molinaro, Kelly A Hartman, Christian Boada, Roman Sukhovershin, Enrica De Rosa, Dickson Kirui, Shanrong Zhang, Michael Evangelopoulos, Angela M Carter, James A Bibb, John P Cooke, Ennio Tasciotti
Activation of the vascular endothelium is characterized by increased expression of vascular adhesion molecules and chemokines. This activation occurs early in the progression of several diseases and triggers the recruitment of leukocytes. Inspired by the tropism of leukocytes, we investigated leukocyte-based biomimetic nanoparticles (i.e., leukosomes) as a novel theranostic platform for inflammatory diseases. Methods : Leukosomes were assembled by combining phospholipids and membrane proteins from leukocytes...
2018: Theranostics
https://www.readbyqxmd.com/read/29461172/radiomics-based-on-adapted-diffusion-kurtosis-imaging-helps-to-clarify-most-mammographic-findings-suspicious-for-cancer
#3
Sebastian Bickelhaupt, Paul Ferdinand Jaeger, Frederik Bernd Laun, Wolfgang Lederer, Heidi Daniel, Tristan Anselm Kuder, Lorenz Wuesthof, Daniel Paech, David Bonekamp, Alexander Radbruch, Stefan Delorme, Heinz-Peter Schlemmer, Franziska Hildegard Steudle, Klaus Hermann Maier-Hein
Purpose To evaluate a radiomics model of Breast Imaging Reporting and Data System (BI-RADS) 4 and 5 breast lesions extracted from breast-tissue-optimized kurtosis magnetic resonance (MR) imaging for lesion characterization by using a sensitivity threshold similar to that of biopsy. Materials and Methods This institutional study included 222 women at two independent study sites (site 1: training set of 95 patients; mean age ± standard deviation, 58.6 years ± 6.6; 61 malignant and 34 benign lesions; site 2: independent test set of 127 patients; mean age, 58...
February 20, 2018: Radiology
https://www.readbyqxmd.com/read/29458284/technical-analysis-of-us-imaging-for-precise-microwave-ablation-for-benign-breast-tumours
#4
Changwen Li, Cuiying Li, Han Ge, Mengdi Liang, Ge Ma, Lijun Ling, Hong Pan, Haiyan Gong, Hui Xie, Qiang Ding, Wenbin Zhou, Shui Wang
PURPOSE: To determine thecharacteristicsof ultrasound (US) imaging of completelyablated cases and theeffects of duration and clinical experience on accurate microwave ablation (MWA) for the treatment of benign breast tumours. METHODS: With written informed consent and approval of the institutional ethics committee, patients with symptomatic or palpable benign breast tumours (longest diameter, 7-32mm), to whom MWA (2450MHz) was performed, were enrolled in this prospective nonrandomized study...
February 19, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29450800/the-endogenous-subcellular-localisations-of-the-long-chain-fatty-acid-activating-enzymes-acsl3-and-acsl4-in-sarcoma-and-breast-cancer-cells
#5
Yassmeen Radif, Haarith Ndiaye, Vasiliki Kalantzi, Ruth Jacobs, Andrew Hall, Shane Minogue, Mark G Waugh
Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxidation for ATP generation or the lipogenic routes that generate bioactive lipids such as the inositol phospholipids. Fatty acid activation by the addition of coenzyme A is catalysed by a family of enzymes called the acyl CoA synthetase ligases (ACSL). Furthermore, enhanced expression of particular ACSL isoforms, such as ACSL4, is a feature of some more aggressive cancers and may contribute to the oncogenic phenotype...
February 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29448628/functionalized-magnetic-plga-nanospheres-for-targeting-and-bioimaging-of-breast-cancer
#6
Seung-Jun Lee, Hee-Jin Kim, Yong-Min Huh, Il Won Kim, Jae Hyun Jeong, Jin-Chul Kim, Jong-Duk Kim
Superparamagnetic iron oxide nanoparticles (SPIONs) are actively used as highly sensitive imaging probes to provide contrast in MRI. In this study, we propose the use of SPIONs encapsulated with antibody-conjugated poly(lactic-co-glycolic acid) (PLGA) as a potent theragnostic agent. The SPIONs were synthesized by a chemical co-precipitation method of ferric and ferrous ions, and subsequently encapsulated with PLGA by using an emulsification-diffusion method. Herceptin was chemically conjugated to the SPION-encapsulating PLGA nanoparticles to target the human epidermal growth factor receptor 2 (Her2/neu) overexpressing breast cancers...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29446125/feasibility-of-high-spatiotemporal-resolution-for-an-abbreviated-3d-radial-breast-mri-protocol
#7
Jorge E Jimenez, Roberta M Strigel, Kevin M Johnson, Leah C Henze Bancroft, Scott B Reeder, Walter F Block
PURPOSE: To develop a volumetric imaging technique with 0.8-mm isotropic resolution and 10-s/volume rate to detect and analyze breast lesions in a bilateral, dynamic, contrast-enhanced MRI exam. METHODS: A local low-rank temporal reconstruction approach that also uses parallel imaging and spatial compressed sensing was designed to create rapid volumetric frame rates during a contrast-enhanced breast exam (vastly undersampled isotropic projection [VIPR] spatial compressed sensing with temporal local low-rank [STELLR])...
February 14, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29433060/dual-tumor-targeted-multifunctional-magnetic-hyaluronic-acid-micelles-for-enhanced-mr-imaging-and-combined-photothermal-chemotherapy
#8
Shaohui Zheng, Jiwon Han, Zhen Jin, Chang-Sei Kim, Sukho Park, Kyu-Pyo Kim, Jong-Oh Park, Eunpyo Choi
Multifunctional polymeric micelles were developed as a promising dual tumor-targeted drug delivery platform for magnetic resonance (MR) imaging and combined photothermal-chemotherapy. HA-C16 copolymers were synthesized via peptide formation process with subsequent co-encapsulation of therapeutic agent docetaxel (DTX) and superparamagnetic iron oxide nanoparticles (SPIONs) to form the multifunctional micelles. The micelles exhibited uniform nanosize and remarkable colloidal stability in aqueous solution. The sustained drug release behavior from HA micelles was observed over the test period...
February 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29430478/use-of-clinical-mri-maximum-intensity-projections-for-improved-breast-lesion-classification-with-deep-convolutional-neural-networks
#9
Natalia Antropova, Hiroyuki Abe, Maryellen L Giger
Deep learning methods have been shown to improve breast cancer diagnostic and prognostic decisions based on selected slices of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). However, incorporation of volumetric and temporal components into DCE-MRIs has not been well studied. We propose maximum intensity projection (MIP) images of subtraction MRI as a way to simultaneously include four-dimensional (4-D) images into lesion classification using convolutional neural networks (CNN). The study was performed on a dataset of 690 cases...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29430472/phantom-based-study-exploring-the-effects-of-different-scatter-correction-approaches-on-the-reconstructed-images-generated-by-contrast-enhanced-stationary-digital-breast-tomosynthesis
#10
Connor Puett, Christina Inscoe, Yueh Z Lee, Otto Zhou, Jianping Lu
Stationary digital breast tomosynthesis (sDBT) is an emerging technology in which the single rotating x-ray tube is replaced by a fixed array of multiple carbon nanotube-enabled sources, providing a higher spatial and temporal resolution. As such, sDBT offers a promising platform for contrast-enhanced (CE) imaging. However, given the minimal enhancement above background with standard operational tube settings and iodine dosing, CE breast imaging requires additional acquisition steps to isolate the iodine signal, using either temporal or dual energy subtraction (TS or DES) protocols...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29429940/review-of-novel-sentinel-lymph-node-biopsy-techniques-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#11
REVIEW
Yeliz Emine Ersoy, Huseyin Kadioglu
Breast cancer patients who present with nodal metastasis receive neoadjuvant chemotherapy (NAC) with increasing frequency and can have complete pathologic response after treatment. In this clinical scenario, sentinel node mapping and biopsy are gaining acceptance instead of axillary dissection to avoid morbidity. Biopsy proven positive lymph nodes must be reliably excised and examined after NAC to further decrease the false negativity rate of sentinel lymph node (SLN) surgery. The standard method for axillary staging in breast cancer patients even after NAC is SLN biopsy (SLNB) with a radioisotope, blue dye, or both (dual technique)...
January 31, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29428211/an-mri-based-radiomics-classifier-for-preoperative-prediction-of-ki-67-status-in-breast-cancer
#12
Cuishan Liang, Zixuan Cheng, Yanqi Huang, Lan He, Xin Chen, Zelan Ma, Xiaomei Huang, Changhong Liang, Zaiyi Liu
RATIONALE AND OBJECTIVES: This study aims to investigate the value of a magnetic resonance imaging-based radiomics classifier for preoperatively predicting the Ki-67 status in patients with breast cancer. MATERIALS AND METHODS: We chronologically divided 318 patients with clinicopathologically confirmed breast cancer into a training dataset (n = 200) and a validation dataset (n = 118). Radiomics features were extracted from T2-weighted (T2W) and contrast-enhanced T1-weighted (T1+C) images of breast cancer...
February 7, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29427210/a-study-of-association-of-oncotype-dx-recurrence-score-with-dce-mri-characteristics-using-multivariate-machine-learning-models
#13
Ashirbani Saha, Michael R Harowicz, Weiyao Wang, Maciej A Mazurowski
PURPOSE: To determine whether multivariate machine learning models of algorithmically assessed magnetic resonance imaging (MRI) features from breast cancer patients are associated with Oncotype DX (ODX) test recurrence scores. METHODS: A set of 261 female patients with invasive breast cancer, pre-operative dynamic contrast enhanced magnetic resonance (DCE-MR) images and available ODX score at our institution was identified. A computer algorithm extracted a comprehensive set of 529 features from the DCE-MR images of these patients...
February 9, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29399889/local-contrast-enhanced-mr-images-via-high-dynamic-range-processing
#14
Shekhar S Chandra, Craig Engstrom, Jurgen Fripp, Ales Neubert, Jin Jin, Duncan Walker, Olivier Salvado, Charles Ho, Stuart Crozier
PURPOSE: To develop a local contrast-enhancing and feature-preserving high dynamic range (HDR) image processing algorithm for multichannel and multisequence MR images of multiple body regions and tissues, and to evaluate its performance for structure visualization, bias field (correction) mitigation, and automated tissue segmentation. METHODS: A multiscale-shape and detail-enhancement HDR-MRI algorithm is applied to data sets of multichannel and multisequence MR images of the brain, knee, breast, and hip...
February 4, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29394537/-a-case-of-adenoma-of-the-nipple-suspected-of-breast-cancer
#15
Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Tamami Morisaki, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira
Adenoma of the nipple is a rare benign tumor, and it is important to distinguish from Paget's disease or breast cancer. A 45- year-old woman had found induration under the right areola before 2 months and visited our hospital. Ultrasonography showed a 2.4 cm solid tumor in a cystic lesion, which had high blood flow in E area of the right mammary gland. The tumor suspected as duct papillomatosis by core needle biopsy. No metastasis lesion was found by computed tomography and bone scintigraphy. But magnetic resonance imaging showed as a marginally clear tumor with contrast enhanced findings that were relatively early reinforced and prolonged...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29392160/distinguishing-benign-and-malignant-breast-tumors-preliminary-comparison-of-kinetic-modeling-approaches-using-multi-institutional-dynamic-contrast-enhanced-mri-data-from-the-international-breast-mr-consortium-6883-trial
#16
Anna G Sorace, Savannah C Partridge, Xia Li, Jack Virostko, Stephanie L Barnes, Daniel S Hippe, Wei Huang, Thomas E Yankeelov
Comparative preliminary analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data collected in the International Breast MR Consortium 6883 multicenter trial was performed to distinguish benign and malignant breast tumors. Prebiopsy DCE-MRI data from 45 patients with suspicious breast lesions were obtained. Semiquantitative mean signal-enhancement ratio ([Formula: see text]) was calculated for all lesions, and quantitative pharmacokinetic, parameters [Formula: see text], [Formula: see text], and [Formula: see text], were calculated for the subset with available [Formula: see text] maps ([Formula: see text])...
January 2018: Journal of Medical Imaging
https://www.readbyqxmd.com/read/29388800/stromal-fibrosis-imaging-features-with-diagnostic-contribution-of-diffusion-weighted-mr-imaging
#17
Ravza Yilmaz, Zuhal Bayramoglu, Merve Gulbiz Kartal, Emine Caliskan, Artur Salmaslioglu, Memduh Dursun, Gulden Acunas
OBJECTIVE: To describe magnetic resonance imaging (MRI) and ultrasonography (US) findings of breast stromal fibrosis (SF) and compare apparent diffusion coefficient (ADC) stromal fibrosis values with breast cancer and normal parenchyma. METHODS: Forty-five patients (ages 22‒74) with histopathologically proven SF who underwent MRI were included in this study. Their MRI and US features were examined and categorized. The mean ADC values for SF contralateral normal parenchyma, and breast malignancy of the control group values were calculated and compared among each other...
February 1, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29380033/contrast-enhanced-mri-after-neoadjuvant-chemotherapy-of-breast-cancer-lesion-to-background-parenchymal-signal-enhancement-ratio-for-discriminating-pathological-complete-response-from-minimal-residual-tumour
#18
Soo-Yeon Kim, Nariya Cho, Sung Ui Shin, Han-Byoel Lee, Wonshik Han, In Ae Park, Bo Ra Kwon, Soo Yeon Kim, Su Hyun Lee, Jung Min Chang, Woo Kyung Moon
OBJECTIVES: To retrospectively investigate whether the lesion-to-background parenchymal signal enhancement ratio (SER) on breast MRI can distinguish pathological complete response (pCR) from minimal residual cancer following neoadjuvant chemotherapy (NAT), and compare its performance with the conventional criterion. METHODS: 216 breast cancer patients who had undergone NAT and MRI and achieved pCR or minimal residual cancer on surgical histopathology were included...
January 29, 2018: European Radiology
https://www.readbyqxmd.com/read/29374745/intensity-and-pattern-of-enhancement-on-cesm-prognostic-significance-and-its-relation-to-expression-of-podoplanin-in-tumor-stroma-a-preliminary-report
#19
Elzbieta Luczynska, Joanna Niemiec, Sylwia Heinze, Agnieszka Adamczyk, Aleksandra Ambicka, Paulina Marcyniuk, Wojciech Rudnicki, Jerzy W Mitus, Sonia Dyczek, Janusz Rys, Beata Sas-Korczynska
BACKGROUND/AIM: It is possible that the degree of enhancement on contrast-enhanced spectral mammography (CESM), a new diagnostic method, might provide prognostic information for breast cancer patients. Therefore, in a group of 82 breast cancer patients, we analyzed the prognostic significance of degree and pattern of enhancement on CESM as well as its relation to: (a) breast cancer immunophenotype (based on ER/PR/HER2 status) (b) podoplanin expression in cancer stroma (lymphatic vessel density plus podoplanin-positivity of cancer-associated fibroblasts), and (c) other histological parameters...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29371992/prediction-of-low-risk-breast-cancer-using-quantitative-dce-mri-and-its-pathological-basis
#20
Tingting Xu, Lin Zhang, Hong Xu, Sifeng Kang, Yali Xu, Xiaoyu Luo, Ting Hua, Guangyu Tang
Purpose: This study aimed to evaluate the difference of mass in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) characteristics between low-risk and non-low-risk breast cancers and to explore the possible pathological basis. Materials and Methods: Approval from the institutional review board and informed consent were acquired for this study. The MR images of 104 patients with pathologically proven breast cancer (104 lesions) were prospectively analyzed...
December 26, 2017: Oncotarget
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