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Contrast enhanced breast imaging

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https://www.readbyqxmd.com/read/29028311/radiolabeled-antibody-conjugated-manganese-oxide-nanoparticles-for-tumor-vasculature-targeted-positron-emission-tomography-and-magnetic-resonance-imaging
#1
Yonghua Zhan, Sixiang Shi, Emily B Ehlerding, Stephen A Graves, Shreya Goel, Jonathan W Engle, Jimin Liang, Jie Tian, Weibo Cai
Manganese oxide nanoparticles (Mn3O4 NPs) have attracted a great deal of attention in the field of biomedical imaging because of their ability to create an enhanced imaging signal in MRI as novel potent T1 contrast agents. In this study, we present tumor vasculature-targeted imaging in mice using Mn3O4 NPs through conjugation to the anti-CD105 antibody TRC105 and radionuclide copper-64 ((64)Cu, t1/2: 12.7 h). The Mn3O4 conjugated NPs, (64)Cu-NOTA-Mn3O4@PEG-TRC105, exhibited sufficient stability in vitro and in vivo...
October 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29025210/up-to-date-doppler-techniques-for-breast-tumor-vascularity-superb-microvascular-imaging-and-contrast-enhanced-ultrasound
#2
Ah Young Park, Bo Kyoung Seo
Ultrasonographic Doppler techniques have improved greatly over the years, allowing more sophisticated evaluation of breast tumor vascularity. Superb microvascular imaging (SMI) and contrast-enhanced ultrasound (CEUS) with second-generation contrast agents are two representative up-to-date techniques. SMI is a sensitive Doppler technique that adopts an intelligent filter system to separate low-flow signals from artifacts. With the development of second-generation contrast agents, CEUS has also emerged as a useful Doppler technique for evaluating tumor microcirculation...
August 19, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28987661/contamination-artifact-that-mimics-in-situ-carcinoma-on-contrast-enhanced-digital-mammography
#3
Jill Gluskin, Michael Click, Richard Fleischman, Clarisse Dromain, Elizabeth A Morris, Maxine S Jochelson
PURPOSE: Contrast-enhanced digital mammography (CEDM) is an advanced breast imaging technique using iodinated intravenous contrast to detect breast cancer. This article describes imaging features of a skin contamination artifact on CEDM that mimics in-situ carcinoma in a case series. MATERIALS AND METHODS: Five patients were identified whose CEDM images demonstrated apparent calcifications and non-mass enhancement suspicious for in-situ carcinoma, with no subsequent evidence of disease...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28982848/lipofilling-outcomes-mimicking-breast-cancer-recurrence-case-report-and-update-of-the-literature
#4
REVIEW
Silvia Gigli, Maria Ida Amabile, Francesca DI Pastena, Alessandro DE Luca, Caterina Gulia, Lucia Manganaro, Massimo Monti, Laura Ballesio
Breast lipofilling uses autologous fat grafting to correct breast defects after radical or conservative surgery. After early concerns regarding its application in reconstruction after breast cancer (BC), in 2009 the American Society of Plastic Surgeons formed a task force to assess the indications, safety and efficacy of autologous fat grafting. We report the case of a woman who came to our attention for a painful swelling of the left breast. She had undergone breast-conserving therapy for BC, followed by lipofilling...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28982628/first-in-human-study-of-acoustic-angiography-in-the-breast-and-peripheral-vasculature
#5
Sarah E Shelton, Brooks D Lindsey, Paul A Dayton, Yueh Z Lee
Screening with mammography has been found to increase breast cancer survival rates by about 20%. However, the current system in which mammography is used to direct patients toward biopsy or surgical excision also results in relatively high rates of unnecessary biopsy, as 66.8% of biopsies are benign. A non-ionizing radiation imaging approach with increased specificity might reduce the rate of unnecessary biopsies. Quantifying the vascular characteristics within and surrounding lesions represents one potential target for assessing likelihood of malignancy via imaging...
October 2, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28980886/features-from-computerized-texture-analysis-of-breast-cancers-at-pretreatment-mr-imaging-are-associated-with-response-to-neoadjuvant-chemotherapy
#6
Foucauld Chamming's, Yoshiko Ueno, Romuald Ferré, Ellen Kao, Anne-Sophie Jannot, Jaron Chong, Atilla Omeroglu, Benoît Mesurolle, Caroline Reinhold, Benoit Gallix
Purpose To evaluate whether features from texture analysis of breast cancers were associated with pathologic complete response (pCR) after neoadjuvant chemotherapy and to explore the association between texture features and tumor subtypes at pretreatment magnetic resonance (MR) imaging. Materials and Methods Institutional review board approval was obtained. This retrospective study included 85 patients with 85 breast cancers who underwent breast MR imaging before neoadjuvant chemotherapy between April 10, 2008, and March 12, 2015...
October 4, 2017: Radiology
https://www.readbyqxmd.com/read/28977682/mri-to-predict-nipple-areola-complex-nac-involvement-an-automatic-method-to-compute-the-3d-distance-between-the-nac-and-tumor
#7
Valentina Giannini, Veronica Bianchi, Silvia Carabalona, Simone Mazzetti, Furio Maggiorotto, Franziska Kubatzki, Daniele Regge, Riccardo Ponzone, Laura Martincich
OBJECTIVES: To assess the role in predicting nipple-areola complex (NAC) involvement of a newly developed automatic method which computes the 3D tumor-NAC distance. PATIENTS AND METHODS: Ninety-nine patients scheduled to nipple sparing mastectomy (NSM) underwent magnetic resonance (MR) examination at 1.5 T, including sagittal T2w and dynamic contrast enhanced (DCE)-MR imaging. An automatic method was developed to segment the NAC and the tumor and to compute the 3D distance between them...
October 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28961567/abbreviated-mri-and-accelerated-mri-for-screening-and-diagnosis-of-breast-cancer
#8
Deepa Sheth, Hiroyuki Abe
Although published studies have revealed that magnetic resonance imaging (MRI) is by far the most effective imaging modality for cancer detection, it is currently considered cost-ineffective for screening women at an intermediate risk for breast cancer. The concept of an "abbreviated MRI" protocol has recently emerged as a possible solution for reducing the cost of MRI. The abbreviated MRI is a shortened version of the standard MRI, consisting of a single early phase dynamic contrast enhanced (DCE) series. Several clinical studies have shown that this MRI protocol would not affect sensitivity or specificity for breast MRI screening purposes...
October 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28949967/preoperative-indication-for-systemic-therapy-extended-to-patients-with-early-stage-breast-cancer-using-multiparametric-7-tesla-breast-mri
#9
A M T Schmitz, W B Veldhuis, M B E Menke-Pluijmers, W J M van der Kemp, T A van der Velden, M A Viergever, W P T M Mali, M C J M Kock, P J Westenend, D W J Klomp, K G A Gilhuijs
PURPOSE: To establish a preoperative decision model for accurate indication of systemic therapy in early-stage breast cancer using multiparametric MRI at 7-tesla field strength. MATERIALS AND METHODS: Patients eligible for breast-conserving therapy were consecutively included. Patients underwent conventional diagnostic workup and one preoperative multiparametric 7-tesla breast MRI. The postoperative (gold standard) indication for systemic therapy was established from resected tumor and lymph-node tissue, based on 10-year risk-estimates of breast cancer mortality and relapse using Adjuvant! Online...
2017: PloS One
https://www.readbyqxmd.com/read/28948442/correlation-between-voxel-wise-enhancement-parameters-on-dce-mri-and-pathological-prognostic-factors-in-invasive-breast-cancers
#10
Rubina Manuela Trimboli, Marina Codari, Katia Khouri Chalouhi, Ileana Ioan, Giovanna Lo Bue, Arianna Ottini, Daniela Casolino, Luca Alessandro Carbonaro, Francesco Sardanelli
PURPOSE: To investigate the correlation between enhancement parameters on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and pathologic prognostic factors in invasive breast cancers (BCs). MATERIALS AND METHODS: A total of 25 invasive BCs were included: 22 invasive ductal, 2 invasive lobular and 1 invasive mucinous. The tumor volume was segmented using a semi-automatic software (Olea Sphere). The following voxel-wise enhancement parameters were extracted: (1) time to peak enhancement; (2) signal intensity at peak (SIP); (3) peak enhancement percentage (PEP); (4) post-initial enhancement percentage (PIEP)...
September 25, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28947734/targeted-gadofullerene-for-sensitive-magnetic-resonance-imaging-and-risk-stratification-of-breast-cancer
#11
Zheng Han, Xiaohui Wu, Sarah Roelle, Chuheng Chen, William P Schiemann, Zheng-Rong Lu
Molecular imaging of cancer biomarkers is critical for non-invasive accurate cancer detection and risk-stratification in precision healthcare. A peptide-targeted tri-gadolinium nitride metallofullerene, ZD2-Gd3N@C80, is synthesised for sensitive molecular magnetic resonance imaging of extradomain-B fibronectin in aggressive tumours. ZD2-Gd3N@C80 has superior r 1 and r 2 relaxivities of 223.8 and 344.7 mM(-1 )s(-1) (1.5 T), respectively. It generates prominent contrast enhancement in aggressive MDA-MB-231 triple negative breast cancer in mice at a low dose (1...
September 25, 2017: Nature Communications
https://www.readbyqxmd.com/read/28946110/contrast-enhancement-on-cone-beam-breast-ct-for-discrimination-of-breast-cancer-immunohistochemical-subtypes
#12
Johannes Uhlig, Uwe Fischer, Eva von Fintel, Vera Stahnke, Christina Perske, Joachim Lotz, Susanne Wienbeck
PURPOSE: To evaluate whether contrast enhancement on cone-beam breast-CT (CBBCT) could aid in discrimination of breast cancer subtypes and receptor status. METHODS: This study included female patients age >40 years with malignant breast lesions identified on contrast-enhanced CBBCT. Contrast enhancement of malignant breast lesions was standardized to breast fat tissue contrast enhancement. All breast lesions were approved via image-guided biopsy or surgery. Immunohistochemical staining was conducted for expression of estrogen (ER), progesterone (PR), human epidermal growth factor receptor-2 (HER2) and Ki-67 index...
September 22, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28941757/contrast-enhanced-spectral-mammography-as-work-up-tool-in-patients-recalled-from-breast-cancer-screening-has-low-risks-and-might-hold-clinical-benefits
#13
I P L Houben, P Van de Voorde, C R L P N Jeukens, J E Wildberger, L F Kooreman, M L Smidt, M B I Lobbes
OBJECTIVE: Contrast-enhanced spectral mammography (CESM) is a reliable problem solving tool in the work-up of women recalled from breast cancer screening. We evaluated additional findings caused by CESM alone and outweighed them against the disadvantages of this technique. METHODS: From December 2012 to December 2015, all women recalled from screening who underwent CESM were considered for this study. Radiation exposure and number of adverse contrast reactions were analysed...
September 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28940426/effects-of-different-preprocessing-algorithms-on-the-prognostic-value-of-breast-tumour-microscopic-images
#14
D Kolarević, T Vujasinović, K Kanjer, J Milovanović, N Todorović-Raković, D Nikolić-Vukosavljević, M Radulovic
The purpose of this study was to improve the prognostic value of tumour histopathology image analysis methodology by image preprocessing. Key image qualities were modified including contrast, sharpness and brightness. The texture information was subsequently extracted from images of haematoxylin/eosin-stained tumour tissue sections by GLCM, monofractal and multifractal algorithms without any analytical limitation to predefined structures. Images were derived from patient groups with invasive breast carcinoma (BC, 93 patients) and inflammatory breast carcinoma (IBC, 51 patients)...
September 21, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28939952/2d-and-3d-texture-analysis-to-differentiate-brain-metastases-on-mr-images-proceed-with-caution
#15
Monika Béresová, Andrés Larroza, Estanislao Arana, József Varga, László Balkay, David Moratal
OBJECTIVE: To find structural differences between brain metastases of lung and breast cancer, computing their heterogeneity parameters by means of both 2D and 3D texture analysis (TA). MATERIALS AND METHODS: Patients with 58 brain metastases from breast (26) and lung cancer (32) were examined by MR imaging. Brain lesions were manually delineated by 2D ROIs on the slices of contrast-enhanced T1-weighted (CET1) images, and local binary patterns (LBP) maps were created from each region...
September 22, 2017: Magma
https://www.readbyqxmd.com/read/28938160/nilotinib-enhances-tumor-angiogenesis-and-counteracts-vegfr2-blockade-in-an-orthotopic-breast-cancer-xenograft-model-with-desmoplastic-response
#16
Sara Zafarnia, Jessica Bzyl-Ibach, Igor Spivak, Yongping Li, Susanne Koletnik, Dennis Doleschel, Anne Rix, Sibylle Pochon, Isabelle Tardy, Seena Koyadan, Marc van Zandvoort, Moritz Palmowski, Fabian Kiessling, Wiltrud Lederle
Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR)-targeted therapies predominantly affect nascent, immature tumor vessels. Since platelet-derived growth factor receptor (PDGFR) blockade inhibits vessel maturation and thus increases the amount of immature tumor vessels, we evaluated whether the combined PDGFR inhibition by nilotinib and VEGFR2 blockade by DC101 has synergistic therapy effects in a desmoplastic breast cancer xenograft model. In this context, besides immunohistological evaluation, molecular ultrasound imaging with BR55, the clinically used VEGFR2-targeted microbubbles, was applied to monitor VEGFR2-positive vessels noninvasively and to assess the therapy effects on tumor angiogenesis...
September 19, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28935459/clinical-and-pathologic-features-of-clinically-occult-synchronous-bilateral-breast-cancers
#17
Lumarie Santiago, Gary Whitman, Cuiyan Wang, Basak E Dogan
PURPOSE: To investigate clinicopathologic breast cancer characteristics associated with the identification of synchronous bilateral breast cancer (SBBC) on dynamic contrast-enhanced breast magnetic resonance imaging. METHODS: We performed a retrospective review of 311 consecutive patients newly diagnosed with breast cancer who underwent diagnostic mammography, ultrasonography, and dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI) at our institution...
August 24, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28932236/quantitative-evaluation-of-temporal-regularizers-in-compressed-sensing-dynamic-contrast-enhanced-mri-of-the-breast
#18
Dong Wang, Lori R Arlinghaus, Thomas E Yankeelov, Xiaoping Yang, David S Smith
PURPOSE: Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is used in cancer imaging to probe tumor vascular properties. Compressed sensing (CS) theory makes it possible to recover MR images from randomly undersampled k-space data using nonlinear recovery schemes. The purpose of this paper is to quantitatively evaluate common temporal sparsity-promoting regularizers for CS DCE-MRI of the breast. METHODS: We considered five ubiquitous temporal regularizers on 4...
2017: International Journal of Biomedical Imaging
https://www.readbyqxmd.com/read/28929243/discrimination-between-benign-and-malignant-breast-lesions-using-volumetric-quantitative-dynamic-contrast-enhanced-mr-imaging
#19
Ziliang Cheng, Zhuo Wu, Guangzi Shi, Zhilong Yi, Mingwei Xie, Weike Zeng, Chao Song, Chushan Zheng, Jun Shen
OBJECTIVE: To determine the diagnostic performance of volumetric quantitative dynamic contrast-enhanced MRI (qDCE-MRI) in differentiation between malignant and benign breast lesions. METHODS: DCE-MRI was performed in 124 patients with 136 breast lesions. Quantitative pharmacokinetic parameters K(trans), Kep, Ve, Vp and semi-quantitative parameters TTP, MaxCon, MaxSlope, AUC were obtained by using a two-compartment extended Tofts model and three-dimensional volume of interest...
September 19, 2017: European Radiology
https://www.readbyqxmd.com/read/28915312/dce-and-dw-mri-as-early-imaging-biomarkers-of-treatment-response-in-a-preclinical-model-of-triple-negative-breast-cancer
#20
Stephanie L Barnes, Anna G Sorace, Jennifer G Whisenant, J Oliver McIntyre, Hakmook Kang, Thomas E Yankeelov
This work evaluates quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted MRI (DW-MRI) parameters as early biomarkers of response in a preclinical model of triple negative breast cancer (TNBC). The standard Tofts' model of DCE-MRI returns estimates of the volume transfer constant (K(trans) ) and the extravascular extracellular volume fraction (ve ). DW-MRI returns estimates of the apparent diffusion coefficient (ADC). Mice (n = 38) were injected subcutaneously with MDA-MB-231...
September 15, 2017: NMR in Biomedicine
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