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Ceftaroline

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https://www.readbyqxmd.com/read/29659853/in-vitro-activity-of-ceftaroline-against-clinical-staphylococcus-aureus-isolates-collected-during-a-national-survey-conducted-in-belgian-hospitals
#1
M Angeles Argudín, M Dodémont, M Taguemount, S Roisin, R de Mendonça, A Deplano, C Nonhoff, O Denis
No abstract text is available yet for this article.
April 5, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29651552/prevention-of-high-level-daptomycin-resistance-emergence-in-vitro-in-streptococcus-mitis-oralis-by-using-combination-antimicrobial-strategies
#2
Brianne Zapata, Danya N Alvarez, Sabrina Farah, Cristina Garcia-de-la-Maria, Jose M Miro, George Sakoulas, Arnold S Bayer, Nagendra N Mishra
Among the viridans group streptococci, S. mitis-oralis strains are frequently resistant to multiple β-lactams and tolerant to vancomycin (VAN). This scenario has led to the proposed clinical use of newer agents, like daptomycin (DAP) for such S. mitis-oralis strains. However, recent recognition of the rapid and durable emergence of high-level DAP-resistance (DAP-R; DAP MICs > 256 µg/ml) induced by DAP exposures in vitro and in vivo has dampened enthusiasm for such approaches. In this study, we evaluated a broad range of DAP combination regimens in vitro for their capacity to prevent emergence of high-level DAP-R in a prototype S...
April 12, 2018: Current Microbiology
https://www.readbyqxmd.com/read/29610208/avibactam-pharmacokinetic-pharmacodynamic-targets
#3
Wright W Nichols, Paul Newell, Ian Critchley, Todd Riccobene, Shampa Das
Avibactam is a novel non-β-lactam β-lactamase inhibitor that has been approved in the USA and Europe for use in combination with ceftazidime. Combinations of avibactam with aztreonam or ceftaroline fosamil have also been clinically evaluated. Until recently, there has been very little precedence of which pharmacokinetic/pharmacodynamic (PK/PD) indices and magnitudes are appropriate to use for β-lactamase inhibitors in population PK modeling for analyzing potential doses and susceptibility breakpoints. For avibactam, several preclinical studies using different in vitro and in vivo models have been conducted to identify the PK/PD index of avibactam and the magnitude of exposure necessary for effect in combination with ceftazidime, aztreonam, or ceftaroline fosamil...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29555635/beta-lactams-combinations-with-vancomycin-provide-synergy-against-vssa-hvisa-and-visa
#4
Kieu-Nhi Tran, Michael J Rybak
Background: Increasing utilization of vancomycin due to the high prevalence of methicillin-resistant S. aureus (MRSA) infections has lead to the emergence of vancomycin-intermediate S. aureus (VISA) and heterogeneous VISA (hVISA). In vitro data suggest the potential for potent synergy between several beta-lactams and vancomycin. The objective of this study is to evaluate the synergy between beta-lactams and vancomycin against MRSA that is vancomycin susceptible, vancomycin susceptible Staphylococcus aureus (VSSA), hVISA, and VISA...
March 19, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29508663/daptomycin-and-combination-daptomycin-ceftaroline-as-salvage-therapy-for-persistent-methicillin-resistant-staphylococcus-aureus-bacteremia
#5
Nicolas Cortes-Penfield, Nora T Oliver, Andrew Hunter, Maria Rodriguez-Barradas
No abstract text is available yet for this article.
March 6, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29506271/in-vitro-synergism-and-anti-biofilm-activity-of-ampicillin-gentamicin-ceftaroline-and-ceftriaxone-against-enterococcus-faecalis
#6
Lara Thieme, Mareike Klinger-Strobel, Anita Hartung, Claudia Stein, Oliwia Makarewicz, Mathias W Pletz
Background: Enterococci frequently cause severe biofilm-associated infections such as endocarditis. The combination of ampicillin/ceftriaxone has recently been clinically evaluated as non-inferior compared with the standard therapy of ampicillin/gentamicin for treatment of Enterococcus faecalis endocarditis. Ceftaroline is a novel cephalosporin with enhanced activity against Gram-positive bacteria. Objectives: To compare the in vitro effectiveness of the ceftaroline/ampicillin combination with those of gentamicin/ampicillin and ceftriaxone/ampicillin in planktonic and biofilm cultures of clinical E...
February 28, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29466931/comparative-in-vitro-activity-of-ceftaroline-and-comparator-agents-against-nosocomial-gram-negative-and-gram-positive-clinically-significant-bacterial-isolates-from-patients-in-a-teaching-hospital-in-kuwait
#7
Wafaa Jamal, Hayfaa Abdulkareem, Vincent O Rotimi
The objective was to test the in vitro activities of ceftaroline and comparator agents against clinical isolates of Gram-negative and Gram-positive bacteria. Isolates were identified with VITEK II. Susceptibility testing was with E test. A total of 1264 isolates were tested. Compared to other cephalosporins, ceftaroline demonstrated excellent in vitro activities (MIC90 , ≤0.5 mg/L) against Escherichia coli, Salmonella spp. and Haemophilus influenzae. When matched with the comparator cephalosporins, ceftaroline demonstrated the greatest activity against methicillin-susceptible Staphylococcus aureus (MSSA), with MIC90 of 0...
February 21, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29448981/treatment-and-prevention-of-invasive-pneumococcal-disease
#8
A R Domínguez-Alegría, V Pintado, I Barbolla
Invasive pneumococcal disease is a severe infection that mainly affects patients with associated comorbidity. The paediatric conjugate vaccination has resulted in a change in the adult vaccination strategy. The antibiotic resistance of pneumococcus is not currently a severe problem. Nevertheless, the World Health Organisation has included pneumococcus among the bacteria whose treatment requires the introduction of new drugs, such as ceftaroline and ceftobiprole. Although the scientific evidence is still limited, the combination of beta-lactams and macrolides is recommended as empiric therapy for bacteraemic pneumococcal pneumonia...
February 12, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29421316/in-vitro-activity-of-novel-anti-mrsa-comparator-agents-against-staphylococci-involved-in-prosthetic-joint-infections
#9
Christophe Isnard, Anne Dhalluin, Damasie Malandain, Quentin Bruey, Michel Auzou, Jocelyn Michon, Jean-Christophe Giard, François Guérin, Vincent Cattoir
OBJECTIVES: Ceftaroline and ceftobiprole are new parenteral cephalosporins with potent activity against methicillin-resistant (MR) staphylococci, which are the leading cause of prosthetic joint infections (PJIs). The aim of the study was to determine and compare in vitro activities of both molecules against staphylococcal isolates recovered from clinically-documented PJIs. METHODS: A collection of 200 non-redundant clinical isolates (100 Staphylococcus aureus and 100 coagulase-negative staphylococci [CoNS], including 19 and 27 MR isolates, respectively) was studied...
February 5, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29419605/ceftaroline-for-suspected-or-confirmed-invasive-methicillin-resistant-staphylococcus-aureus-a-pharmacokinetic-case-series
#10
Jeffrey J Cies, Wayne S Moore, Adela Enache, Arun Chopra
OBJECTIVES: To describe the ceftaroline pharmacokinetics in critically ill children treated for suspected or confirmed methicillin-resistant Staphylococcus aureus infections, including blood stream infection and describe the microbiological and clinical outcomes. DESIGN: Retrospective electronic medical record review. SETTINGS: Free-standing tertiary/quaternary pediatric children's hospital. PATIENTS: Critically ill children receiving ceftaroline monotherapy or combination therapy for suspected or confirmed methicillin-resistant S...
February 6, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29413881/evolution-of-methicillin-resistant-staphylococcus-aureus-evidence-of-positive-selection-in-a-penicillin-binding-protein-pbp-2a-coding-gene-meca
#11
Xiao-Yong Zhan, Qing-Yi Zhu
Methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) represents more and more S. aureus infections. MecA, the novel coding gene of penicillin-binding protein (PBP) 2a of MRSA, is the key resistance factor of β-lactam, but little is known about the evolution of this gene. Given the crucial role of mecA in S. aureus physiology and β-lactam resistance, the selective forces may contribute to adaptation of the bacteria to the special environments such as its host or antibiotics. To understand the evolution of this gene, we screened GenBank database and analyzed mecA of 249 S...
January 27, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29395713/antimicrobial-activity-of-ceftobiprole-and-comparator-agents-when-tested-against-contemporary-gram-positive-and-negative-organisms-collected-from-europe-2015
#12
M A Pfaller, R K Flamm, L R Duncan, J M Streit, M Castanheira, H S Sader
Susceptibility testing of ceftobiprole and comparators against 12,240 isolates was performed following CLSI/EUCAST guidelines. The percentage of susceptible MRSA isolates was higher for ceftobiprole (96.5% susceptible) than for ceftaroline (86.2% susceptible). Both ceftobiprole (MIC50/90, 0.5/2 mg/L) and ceftaroline (MIC50/90, 0.25/1 mg/L) demonstrated potent activity against coagulase-negative staphylococci. Ceftobiprole demonstrated good potency against Enterococcus faecalis (MIC50/90 values of 0.5/2 mg/L); ceftaroline (MIC50/90, 2/8 mg/L) was 4-fold less active against these strains...
January 3, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29344094/robotic-prostatectomy-leading-to-a-delayed-mrsa-infected-lymphocele-a-case-report-and-review-of-the-literature
#13
Monica Kaminski, Rose Recco, Steven Siegel
Prostate cancer is the second leading cancer-related cause of death in the USA with the majority presenting as localized disease. In the last decade minimally invasive, robotic-assisted laparascopic, radical prostatectomy has become the most favored treatment choice. A complication that has been observed in 27% of patients is the formation of an asymptomatic lymphocele. It is a very rare complication for these to become infected, and when they do 80% have occurred 2-12 months post-procedure. In this case report the patient presented with fever and leukocytosis of unknown origin and was found to have a methicillin-resistant Staphylococcus aureus (MRSA) infected lymphocele over 2 years after a radical prostatectomy...
January 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29343421/frequency-of-small-colony-variants-and-antimicrobial-susceptibility-of-methicillin-resistant-staphylococcus-aureus-in-cystic-fibrosis-patients
#14
Nuntra Suwantarat, Mayer Rubin, Latetia Bryan, Tsigereda Tekle, Michael P Boyle, Karen C Carroll, Mark T Jennings
BACKGROUND: Small-colony variants (SCVs) are a distinct phenotype of Staphylococcus aureus, known for their role in chronic, difficult to treat infections, including cystic fibrosis (CF) lung disease. The goal of this study was to characterize SCV MRSA infection in an adult and pediatric CF population and to identify antibiotic susceptibility patterns unique to SCV MRSA. METHODS: We recovered methicillin-resistant S. aureus (MRSA) from respiratory culture samples from CF patients at the Johns Hopkins Hospital during a 6month study period...
December 2, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29337085/disc-describing-infections-of-the-spine-treated-with-ceftaroline
#15
Richard R Watkins, George Yendewa, Steven D Burdette, Sophia Horattas, Nairmeen Awad Haller, Caroline Mangira, Robert A Salata, Robert A Bonomo
OBJECTIVES: Spine infections lead to considerable morbidity and high cost to the global health care system. Currently, the evidence for using ceftaroline, an advanced-generation cephalosporin active against methicillin-resistant Staphylococcus aureus (MRSA), in spine infections is limited. METHODS: Describing Infections of the Spine treated with Ceftaroline (DISC) is a multicenter retrospective cohort study that evaluated ceftaroline for treating spine infections...
January 11, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29290374/physical-compatibility-of-meropenem-and-vaborbactam-with-select-intravenous-drugs-during-simulated-y-site-administration
#16
James M Kidd, Lindsay M Avery, Tomefa E Asempa, David P Nicolau, Joseph L Kuti
PURPOSE: Meropenem/vaborbactam is a novel intravenous antibiotic combining the carbapenem, meropenem, with a novel β-lactamase inhibitor, vaborbactam. Meropenem/vaborbactam is administered as a 3-hour infusion given every 8 hours, thereby potentially restricting an intravenous line for 9 h/d. Intravenous medications may be given concurrently via Y-site when compatibility data are available. Herein, physical compatibility was determined for the identification which medications can be coadministered with meropenem/vaborbactam via Y-site...
February 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29273611/physical-compatibility-of-fosfomycin-for-injection-with-select-i-v-drugs-during-simulated-y-site-administration
#17
Marguerite L Monogue, Safa S Almarzoky Abuhussain, Joseph L Kuti, David P Nicolau
PURPOSE: The results of a study to determine the physical compatibility of ZTI-01 (fosfomycin for injection) in 0.9% sodium chloride or 5% dextrose during simulated Y-site administration with 37 i.v. antimicrobials and 58 nonantimicrobials are reported. METHODS: Fosfomycin, an epoxide antibiotic with broad-spectrum activity against multidrug-resistant bacteria, is marketed in the United States only in an oral formulation with limited bioavailability, but an i.v...
January 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29237024/comparative-analysis-of-neutropenia-in-patients-receiving-prolonged-treatment-with-ceftaroline
#18
R Brigg Turner, D Erin Wilson, Henry Saedi-Kwon, Eric Chang, Regina Won, Dominic Chan, Jacqueline Schwartz
Objectives: Ceftaroline is often used in durations greater than that studied in clinical trials. Several retrospective, non-comparative studies have suggested a higher than anticipated incidence of neutropenia in patients receiving prolonged treatment with ceftaroline. We sought to determine if ceftaroline was associated with neutropenia by comparing the incidence with ceftaroline treatment with treatment with several comparative antibiotics. Methods: Patients receiving 14 or more consecutive days of treatment with ceftaroline were compared with patients receiving cefazolin, daptomycin, linezolid, nafcillin or vancomycin (control group)...
December 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29173791/new-antimicrobial-agents-for-the-treatment-of-staphylococcal-infections-in-children
#19
REVIEW
Roopali Sharma, Densley Francois, Margaret R Hammerschlag
Several new antimicrobial agents-daptomycin, ceftaroline, telavancin, dalbavancin, and-tedizolid have been approved for the treatment of staphylococcal infections, including methicillin-resistant Staphylococcus aureus (MRSA), in adults. Ceftaroline and daptomycin have been approved by the US Food and Drug Administration for use in children. Ceftaroline, a beta-lactam antibiotic with activity against MRSA, has been approved for treatment of community-acquired bacterial pneumonia and complicated skin and skin structure infections...
December 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29158271/evaluation-of-the-in-vitro-activity-of-ceftaroline-and-comparators-against-s-pneumoniae-isolates-from-u-s-hospitals-results-from-7-years-of-the-aware-surveillance-program-2010-2016
#20
Michael A Pfaller, Rodrigo E Mendes, Leonard R Duncan, Robert K Flamm, Helio S Sader
We evaluated trends in Streptococcus pneumoniae antimicrobial susceptibility in United States hospitals in the 2010--2016 period. A total of 8,768 clinical isolates from 47 medical centers were tested for susceptibility by broth microdilution methods. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) rates decreased from 25.7/12.4% (MDR/XDR) in 2010 to 17.7%/3.6% in 2016. Susceptibility to most comparator antimicrobial agents increased, whereas susceptibility to ceftaroline, levofloxacin, linezolid, and tigecycline remained stable...
November 20, 2017: Antimicrobial Agents and Chemotherapy
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