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Ceftaroline

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https://www.readbyqxmd.com/read/29045693/pharmacokinetics-of-ceftaroline-in-a-preterm-infant-with-methicillin-resistant-staphylococcus-aureus-pneumonia
#1
Sara N Salerno, Janice Bernhardt, Matthew Laughon, Ravi Jhaveri, Matthew Massaro, Daniel Gonzalez
We report here the first pharmacokinetic-pharmacodynamic relationship for ceftaroline in a preterm infant born at <28 weeks' gestational age who was given ceftaroline (8.5 mg/kg every 8 hours) for pneumonia attributable to methicillin-resistant Staphyloccocus aureus. This dose of ceftaroline was adequate to achieve the pharmacodynamic endpoint associated with efficacy for methicillin-resistant Staphyloccocus aureus.
October 16, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29034091/phenotypic-and-genotypic-characterization-of-antibiotic-resistance-of-methicillin-resistant-staphylococcus-aureus-isolated-from-hospital-food
#2
Farhad Safarpoor Dehkordi, Hasan Gandomi, Afshin Akhondzadeh Basti, Ali Misaghi, Ebrahim Rahimi
BACKGROUND: Pathogenic biotypes of the Methicillin-resistant Staphylococcus aureus (MRSA) strains are considered to be one of the major cause of food-borne diseases in hospitals. The present investigation was done to study the pattern of antibiotic resistance and prevalence of antibiotic resistance genes of different biotypes of the MRSA strains isolated from various types of hospital food samples. METHODS: Four-hundred and eighty-five raw and cooked hospital food samples were cultured and MRSA strains were identified using the oxacillin and cefoxitin disk diffusion tests and mecA-based PCR amplification...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29025325/versatility-of-targeted-antibiotic-loaded-gold-nanoconstructs-for-the-treatment-of-biofilm-associated-bacterial-infections
#3
Daniel G Meeker, Tengjiao Wang, Walter N Harrington, Vladimir P Zharov, Sarah A Johnson, Samir V Jenkins, Stephanie E Oyibo, Christopher M Walker, Weston B Mills, Mark E Shirtliff, Karen E Beenken, Jingyi Chen, Mark S Smeltzer
BACKGROUND: We previously demonstrated that a photoactivatable therapeutic approach employing antibiotic-loaded, antibody-conjugated, polydopamine (PDA)-coated gold nanocages (AuNCs) could be used for the synergistic killing of bacterial cells within a biofilm. The approach was validated with a focus on Staphylococcus aureus using an antibody specific for staphylococcal protein A (Spa) and an antibiotic (daptomycin) active against Gram-positive cocci including methicillin-resistant S...
October 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29018016/successful-treatment-of-community-acquired-methicillin-resistant-staphylococcus-aureus-purulent-myopericarditis
#4
Henry DeYoung, Adam Bloom, Sally Tamayo
A previously healthy 48-year-old active duty man, who had been treated for an elbow abscess 3 weeks earlier, presented to an emergency department in Bahrain with tachycardia, pericardial friction rub and jugular venous distention. Cardiac tamponade was confirmed on transthoracic echocardiogram and he was taken for emergent pericardiocentesis. Pericardial fluid cultures grew community-acquired methicillin-resistant Staphylococcus aureus Despite ongoing treatment with intravenous vancomycin, he developed a recurrent fibrinous pericardial effusion and constrictive pericarditis requiring pericardiectomy...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28980484/rate-and-incidence-of-adverse-reactions-associated-with-ceftaroline-exposure-importance-of-cutaneous-manifestations
#5
Jeffrey W Jansen, Ryan P Moenster
BACKGROUND: Ceftaroline is a broad-spectrum, methicillin-resistant Staphylococcus aureus (MRSA)-active β-lactam approved for acute bacterial skin and skin structure infections (ABSSSIs) and community-acquired pneumonia. Because of its favorable spectrum and pharmacokinetics, ceftaroline is frequently utilized for infections such as osteomyelitis and endocarditis. Ceftaroline has been associated with neutropenia, but evaluation of other adverse events remains limited. OBJECTIVE: To describe the rates and types of ceftaroline-associated adverse events and determine if patients' baseline allergies affect the rates of an adverse event...
October 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28961767/intraosteoblastic-activity-of-daptomycin-in-combination-with-oxacillin-and-ceftaroline-against-mssa-and-mrsa
#6
Céline Dupieux, Sophie Trouillet-Assant, Caroline Camus, Lélia Abad, Michèle Bes, Yvonne Benito, Christian Chidiac, Sébastien Lustig, Tristan Ferry, Florent Valour, Frédéric Laurent
Background: The Staphylococcus aureus intracellular reservoir is associated with bone and joint infection (BJI) chronicity. As daptomycin is increasingly prescribed in BJI, strategies for improving its reduced intracellular activity should be promoted. Objectives: Based on the known in vitro synergy of daptomycin with β-lactams, the aim of the present study was to evaluate the intracellular activity of these combinations in an ex vivo osteoblast infection model...
September 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28922808/the-discovery-of-ceftazidime-avibactam-as-an-anti-mycobacterium-avium-agent
#7
Devyani Deshpande, Shashikant Srivastava, Moti L Chapagain, Pooi S Lee, Kayle N Cirrincione, Jotam G Pasipanodya, Tawanda Gumbo
Objectives: To determine if ceftaroline and ceftazidime combined with avibactam are efficacious against pulmonary Mycobacterium avium complex (MAC) disease. Methods: First, we performed a concentration-effect study of ceftaroline and ceftaroline/avibactam against extracellular MAC in test tubes. Given the difficulty of obtaining avibactam at the time of experimentation, we used a single concentration of commercial ceftazidime/avibactam, and two sets of non-treated controls, one with ceftazidime/avibactam and the other without...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28910514/pharmacokinetics-of-single-dose-ceftaroline-fosamil-in-children-with-cystic-fibrosis
#8
Jennifer Le, John S Bradley, Sara Hingtgen, Shannon Skochko, Nanette Black, Ronald N Jones, Meerana Lim, Edmund V Capparelli
BACKGROUND: Single-dose pharmacokinetics (PK) and safety of ceftaroline fosamil with population pharmacokinetic/pharmacodynamic (PK/PD) modeling for staphylococcal pneumonia was performed in children with CF. METHODS: Subjects between 6 and 18 years old were evaluated in this phase 1, open-label, single-dose, prospective study using 10 mg/kg (up to 600 mg). Non-compartmental analysis and population-based PK analyses with Monte Carlo simulation (for doses 8-20 mg/kg every 8 h, infused over 1-4 h) were conducted...
September 14, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28885936/vancomycin-vs-vancomycin-piperacillin-tazobactam-associated-acute-kidney-injury-in-noncritically-ill-patients-at-a-tertiary-care-military-treatment-facility
#9
Caleb W Anderson, Kathy S Cazares, Michael B Lustik, Shivam M Patel, Troy M Denunzio
BACKGROUND: Broad-spectrum antibiotics are often used as initial empiric therapy in patients at risk for infections by multidrug-resistant organisms. Emerging literature and anecdotal reports within Tripler Army Medical Center indicate an increased incidence of vancomycin-associated acute kidney injury when used in combination with piperacillin-tazobactam. This is a retrospective, single-center study comparing the incidence of acute kidney injury in noncritically ill patients receiving either vancomycin or vancomycin in combination with piperacillin-tazobactam in a 206-bed tertiary care military training facility...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28800526/identification-and-determination-of-related-substances-of-ceftaroline-fosamil-in-medicinal-product-by-high-performance-liquid-chromatography-with-diode-array-detection-and-tandem-mass-spectrometry
#10
Izabela Karpiuk, Katarzyna Michalska, Katarzyna Bus, Monika Kiljan, Stefan Tyski
Ceftaroline fosamil, the prodrug of ceftaroline, is an advanced-generation cephalosporin antibacterial agent approved for treatment in the European Union in 2012. The drug is dedicated to curing complicated skin and soft tissue infections and community-acquired pneumonia. The developed analytical method of high performance liquid chromatography (HPLC) followed by diode array detector (DAD) set at 243nm was used to identify and determine degradation products of ceftaroline fosamil. The elaborated method demonstrated good selectivity and linearity [r>0...
October 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28777909/cave-canem-hbo%C3%A2-therapy-efficacy-on-capnocytophaga-canimorsus-infections-a-case-series
#11
Mariano Marmo, Romolo Villani, Raffaele Maria Di Minno, Giuseppe Noschese, Matteo Paganini, Silvia Quartesan, Alex Rizzato, Gerardo Bosco
BACKGROUND: Dog bites are a frequent injury, but the incidence and type of lesions vary across countries. Although only few patients develop complications, the treatment of advanced injuries has a considerable medical, social and economic impact. A frequently isolated pathogen in dog bite wounds is Capnocytophaga canimorsus, a bacterium that can cause sepsis or meningitis. Hyperbaric oxygen (HBO₂) therapy has been shown to be useful in treating anaerobic infections, most likely because it creates an inhospitable environment for the bacterium and enhances the patient's immune response...
March 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28755095/neurological-adverse-effects-attributable-to-%C3%AE-lactam-antibiotics-a-literature-review
#12
REVIEW
Samuel Deshayes, Antoine Coquerel, Renaud Verdon
β-lactam antibiotics are commonly prescribed antibiotic drugs. To describe the clinical characteristics, risk markers and outcomes of β-lactam antibiotic-induced neurological adverse effects, we performed a general literature review to provide updated clinical data about the most used β-lactam antibiotics. For selected drugs in each class available in France (ticarcillin, piperacillin, temocillin, ceftazidime, cefepime, cefpirome, ceftaroline, ceftobiprole, ceftolozane, ertapenem and aztreonam), a systematic literature review was performed up to April 2016 via an electronic search on PubMed...
July 28, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28732783/future-trends-in-the-treatment-of-methicillin-resistant-staphylococcus-aureus-mrsa-infection-an-in-depth-review-of-newer-antibiotics-active-against-an-enduring-pathogen
#13
REVIEW
A M Bal, M Z David, J Garau, T Gottlieb, T Mazzei, F Scaglione, P Tattevin, I M Gould
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major public health problem. Vancomycin and teicoplanin have been in clinical use for several decades but their drawbacks are well described. In the last 10 years, several antibiotics have been made available for clinical use. Daptomycin and linezolid have been extensively used during this period. Other agents such as ceftaroline, ceftobiprole, dalbavancin, oritavancin, tedizolid and telavancin have been approved by regulatory agencies since 2009...
September 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28720485/ceftaroline-modulates-the-innate-immune-and-host-defense-responses-of-immunocompetent-cells-exposed-to-cigarette-smoke
#14
A Bruno, C Cipollina, S Di Vincenzo, L Siena, P Dino, F Di Gaudio, M Gjomarkaj, E Pace
BACKGROUND: Cigarette smoke, the principal risk factor for chronic obstructive pulmonary disease (COPD), negatively influences the effectiveness of the immune system's response to a pathogen. The antibiotic ceftaroline exerts immune-modulatory effects in bronchial epithelial cells exposed to cigarette smoke. AIMS AND METHODS: The present study aims to assess the effects of ceftaroline on TLR2 and TLR4 expression, LPS binding and TNF-α and human beta defensin (HBD2) release in an undifferentiated and PMA-differentiated human monocyte cell line (THP-1) exposed or not to cigarette smoke extracts (CSE)...
September 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28705799/rapid-developing-empyema-by-group-f-beta-streptococcus-anginosus-group
#15
Muhammad Azharuddin, Dy Prudence, Prem Shanker Shukla, Ajay Mathur
A 43-year-old male had progressive pleuritic left-sided chest tightness with shortness of breath. He had dental caries and tenderness on palpation of the left lateral chest. Complete blood count showed leucocytosis. CT scan of the chest with pulmonary emboli protocol showed multiple pulmonary nodules and nodular pleural thickening at left posterior lateral pleura. Forty-eight hours post CTPE scan, CT scan of the chest, abdomen and pelvis displayed right lower lobe consolidation and left-sided pleural effusion with superimposed compressive atelectasis...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28702467/ceftaroline-for-severe-methicillin-resistant-staphylococcus-aureus-infections-a-systematic-review
#16
REVIEW
Reese A Cosimi, Nahal Beik, David W Kubiak, Jennifer A Johnson
Ceftaroline is approved by the Food and Drug Administration for acute bacterial skin and skin-structure infections and community-acquired bacterial pneumonia, including cases with concurrent bacteremia. Use for serious methicillin-resistant Staphylococcus aureus (MRSA) infections has risen for a multitude of reasons. The aim of this article is to review the literature evaluating clinical outcomes and safety of ceftaroline prescribed for serious MRSA infections. We conducted a literature search in Ovid (Medline) and PubMed for reputable case reports, clinical trials, and reviews focusing on the use of ceftaroline for treatment of MRSA infections...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28697650/ceftaroline-for-the-treatment-of-osteomyelitis-caused-by-methicillin-resistant-staphylococcus-aureus-a-case-series
#17
Karineh Lalikian, Rita Parsiani, Regina Won, Eric Chang, R Brigg Turner
Despite limited clinical data, ceftaroline is commonly used for treatment of complicated, invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA). A retrospective chart review was conducted of adult patients receiving ceftaroline for MRSA osteomyelitis admitted between April 2011 and March 2016 at a five-hospital system. Twelve patients met the inclusion criteria. All patients received prior antimicrobial therapy with a median time to switch to ceftaroline of 45.5 days. Five of the 12 patients (41...
July 11, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28666751/recently-approved-antibacterials-for-methicillin-resistant-staphylococcus-aureus-mrsa-and-other-gram-positive-pathogens-the-shock-of-the-new
#18
REVIEW
Michael Z David, Matthew Dryden, Thomas Gottlieb, Pierre Tattevin, Ian M Gould
A number of novel antimicrobial drugs with activity against Gram-positive bacterial pathogens have been licensed in the past 4 years. These drugs have the potential to enrich the group of intravenous drugs already available that are in common use against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci and other antibiotic-resistant Gram-positive pathogens. The advantages and disadvantages of these drugs are not yet fully appreciated. Here we review the five most promising newly approved compounds, namely ceftaroline, ceftobiprole, oritavancin, dalbavancin and tedizolid...
September 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28664412/early-use-of-ceftaroline-fosamil-in-the-united-states-veterans-health-care-system
#19
Rachel S Britt, Kirk E Evoy, Grace C Lee, Kelly R Reveles, Kimberly M Sorensen, Xavier Jones, Mary Bollinger, Christopher R Frei
BACKGROUND: Ceftaroline fosamil is US Food and Drug Administration-approved for acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia, but it is not known how ceftaroline is being used in real-world settings or how adverse effects (AEs) and mortality compare to clinical trials. OBJECTIVE: This study describes ceftaroline use, AEs, and mortality in US Veterans Health Administration (VHA) hospital patients. METHODS: This phase IV, population-based, epidemiologic study analyzed patients ≥18 years old who received one or more ceftaroline doses within 14 days of admission to 69 VHA hospitals in 41 US states/territories from 1 October 2010 to 30 September 2014...
August 2017: Drugs
https://www.readbyqxmd.com/read/28642145/new-and-improved-a-review-of-novel-antibiotics-for-gram-positive-bacteria
#20
REVIEW
M Abbas, M Paul, A Huttner
BACKGROUND: The number of antibiotics in the pipeline targeting Gram-positive pathogens has increased in recent years. AIMS: This narrative review aims to provide a summary of existing evidence on efficacy, microbiological spectrum and safety of novel systemic antibiotics that have either recently been licensed or completed phase III trials, and possess activity predominantly against Gram-positive organisms. SOURCES: A review of the published literature via the MEDLINE database was performed...
October 2017: Clinical Microbiology and Infection
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