Sorin Constantinescu, Adelina-Gabriela Niculescu, Ariana Hudiță, Valentina Grumezescu, Dragoș Rădulescu, Alexandra Cătălina Bîrcă, Gabriela Dorcioman, Oana Gherasim, Alina Maria Holban, Bianca Gălățeanu, Bogdan Ștefan Vasile, Alexandru Mihai Grumezescu, Alexandra Bolocan, Radu Rădulescu
To modulate the bioactivity and boost the therapeutic outcome of implantable metallic devices, biodegradable coatings based on polylactide (PLA) and graphene oxide nanosheets (nGOs) loaded with Zinforo™ (Zin) have been proposed in this study as innovative alternatives for the local management of biofilm-associated periprosthetic infections. Using a modified Hummers protocol, high-purity and ultra-thin nGOs have been obtained, as evidenced by X-ray diffraction (XRD) and transmission electron microscopy (TEM) investigations...
February 17, 2024: International Journal of Molecular Sciences