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Mycobacterium avium

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https://www.readbyqxmd.com/read/28631071/oxidation-of-c18-hydroxy-polyunsaturated-fatty-acids-to-epoxide-or-ketone-by-catalase-related-hemoproteins-activated-with-iodosylbenzene
#1
Tarvi Teder, William E Boeglin, Alan R Brash
Small catalase-related hemoproteins with a facility to react with fatty acid hydroperoxides were examined for their potential mono-oxygenase activity when activated using iodosylbenzene. The proteins tested were a Fusarium graminearum 41 kD catalase hemoprotein (Fg-cat, gene FGSG_02217), a Pseudomonas fluorescens Pfl01 catalase (37.5 kD, accession number WP_011333788.1), and a Mycobacterium avium ssp. paratuberculosis 33 kD catalase (gene MAP-2744c). 13-Hydroxy-octadecenoic acids (which are normally unreactive) were selected as substrates because these enzymes react specifically with the corresponding 13S-hydroperoxides (Pakhomova et al...
June 19, 2017: Lipids
https://www.readbyqxmd.com/read/28629426/development-and-validation-of-a-prognostic-scoring-model-for-mycobacterium-avium-complex-lung-disease-an-observational-cohort-study
#2
Shogo Kumagai, Akihiro Ito, Toru Hashimoto, Satoshi Marumo, Hironobu Tokumasu, Aya Kotani, Haruka Yamaki, Masahiro Shirata, Koji Furuuchi, Motonari Fukui, Tadashi Ishida
BACKGROUND: Patients with Mycobacterium avium complex (MAC) lung disease (LD) have a heterogeneous prognosis. This study aimed to develop and validate a prognostic scoring model for these patients using independent risk factors for survival. METHODS: We retrospectively analyzed the data of patients with MAC-LD from two hospitals (cohort 1, n = 368; cohort 2, n = 118). Cohort 1 was evaluated using a multivariate Cox proportional hazards model to identify independent risk factors for overall survival (OS)...
June 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28629354/acetone-leaf-extracts-of-some-south-african-trees-with-high-activity-against-escherichia-coli-also-have-good-antimycobacterial-activity-and-selectivity-index
#3
Ishaku L Elisha, Francien S Botha, Balungile Madikizela, Lyndy J McGaw, Jacobus N Eloff
BACKGROUND: Tuberculosis is a world-wide problem affecting humans and animals. There is increasing development of resistance of the pathogens to current antimycobacterial agents. Many authors have investigated activities of extracts and isolated compounds from plants. The traditional uses of plants have frequently been the criterion to select plants investigated. In this contribution, we investigate whether plant extracts with very good activity against Escherichia coli may also be active against mycobacteria...
June 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28623935/variation-in-susceptibility-of-different-breeds-of-sheep-to-mycobacterium-avium-subspecies-paratuberculosis-following-experimental-inoculation
#4
D J Begg, A C Purdie, K de Silva, N K Dhand, K M Plain, R J Whittington
Exposure to Mycobacterium avium subspecies paratuberculosis (MAP) does not always lead to Johne's disease. Understanding differences in disease susceptibility of individual animals is a key aspect to controlling mycobacterial diseases. This study was designed to examine the susceptibility or resistance of various breeds of sheep to MAP infection. Merino, Suffolk first cross Merino, Border Leicester, and Poll Dorset sheep were orally inoculated with MAP and monitored for 14 months. Clinical disease occurred more frequently in the Merino (42%) and Suffolk first cross Merino (36%) compared to the Border Leicester (12%) and Poll Dorset (11%) breeds...
June 17, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28623492/recombinant-20-8-kda-protein-of-mycobacterium-avium-subsp-paratuberculosis-based-sero-diagnosis-of-paratuberculosis
#5
P P Goswami, Gokul Chand, N S Prasad, R Deb, S H Basagoudanavar
Johne's disease or paratuberculosis is a chronic infectious enteric disease of ruminants caused by the intracellular pathogen. The control of the Johne's disease is hampered by lack of specific diagnostic tests. In this study, we have cloned and expressed the N-terminal region of the locus tag Map 1637c encoding 20.8-kDa (r20.8) protein of Mycobacterium avium subsp. paratuberculosis. The recombinant protein r20.8 was expressed in high levels in Escherichia coli. The protein r20.8 was purified by single-step chromatography using Ni-NTA agarose...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28619158/low-genetic-diversity-of-bovine-mycobacterium-avium-subspecies-paratuberculosis-isolates-detected-by-miru-vntr-genotyping
#6
Marcel de Kruijf, Olga N Lesniak, Dermot Yearsley, Elvira Ramovic, Aidan Coffey, Jim O'Mahony
Mycobacterial interspersed repetitive unit and variable number tandem repeat (MIRU-VNTR) has been developed as a simple, rapid and cost efficient molecular typing method to differentiate Mycobacterium avium subspecies paratuberculosis (MAP) isolates. The aim of this study was to determine the genomic diversity of MAP across the Republic of Ireland by utilising the MIRU-VNTR typing method on a large collection of MAP isolates. A total of 114 MAP isolates originated from 53 herds across 19 counties in the Republic of Ireland were genotyped based on eight established MIRU-VNTR loci...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28619015/nontuberculosis-mycobacterial-infections-at-a-specialized-tuberculosis-treatment-centre-in-the-republic-of-korea
#7
Hee Jung Yoon, Hwa Young Choi, Moran Ki
BACKGROUND: The incidence of nontuberculous mycobacteria (NTM) infections is increasing worldwide, however formal evaluations of the epidemiology of NTM infections are limited. Understanding the trends and true prevalence of NTM is a major priority for optimizing infection control programmes and resources. The purpose of this study was to investigate the epidemiology, clinical manifestations, and radiologic findings in NTM-infected patients at specialized Tuberculosis (Tb) treatment centre in South Korea, which is endemic to Tb, and find solutions to control NTM infections...
June 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28616081/anaerobic-adaptation-of-mycobacterium-avium-subspecies-paratuberculosis-in-vitro-similarities-to-m-tuberculosis-and-differential-susceptibility-to-antibiotics
#8
Nicole Parrish, Aravinda Vadlamudi, Neil Goldberg
BACKGROUND: Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne's disease in ruminants and is associated with Crohn's disease (CD) in humans, although the latter remains controversial. In this study, we investigated the ability of MAP to adapt to anaerobic growth using the "Wayne" model of non-replicating persistence (NRP) developed for M. tuberculosis. RESULTS: All strains adapted to anaerobiosis over time in a manner similar to that seen with MTB...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28608707/modeling-environmental-transmission-of-map-infection-in-dairy-cows
#9
Kokum R De Silva, Shigetoshi Eda, Suzanne Lenhart
Johne's disease is caused by Mycobacterium avium subspecies paratuberculosis(MAP). It is a chronic, progressive, and inflammatory disease which has a long incubation period. One main problem with the disease is the reduction of milk production in infected dairy cows. In our study we develop a system of ordinary differential equations to describe the dynamics of MAP infection in a dairy farm. This model includes the progression of the disease and the age structure of the cows. To investigate the effect of persistence of this bacteria on the farm on transmission in our model, we include environmental compartments, representing the pathogen input in an explicit way...
August 1, 2017: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/28606745/the-characteristics-of-patients-with-pulmonary-mycobacterium-avium-intracellulare-complex-disease-diagnosed-by-bronchial-lavage-culture-compared-to-those-diagnosed-by-sputum-culture
#10
Koichi Maekawa, Megumi Naka, Saki Shuto, Yuka Harada, Yumiko Ikegami
BACKGROUND AND OBJECTIVE: The utility of bronchoscopy for the diagnosis of pulmonary Mycobacterium avium-intracellulare complex (MAC) disease has been reported; however, which patients require bronchoscopy remains unclear. Our objective was to identify the characteristics of the patients in whom bronchoscopy is needed for the diagnosis of MAC disease. METHODS: Fifty-four patients with pulmonary MAC disease were divided into two groups according to established diagnostic criteria: 39 patients were diagnosed by sputum culture and 15 patients were diagnosed by bronchial lavage culture...
June 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28600772/a-closed-tube-loop-mediated-isothermal-amplification-assay-for-the-visual-endpoint-detection-of-brucella-spp-and-mycobacterium-avium-subsp-paratuberculosis
#11
Marcos D Trangoni, Andrea K Gioffré, Silvio L Cravero
LAMP (loop-mediated isothermal amplification) is an isothermal nucleic acid amplification technique that is characterized by its efficiency, rapidity, high yield of final product, robustness, sensitivity, and specificity, with the blueprint that it can be implemented in laboratories of low technological complexity. Despite the conceptual complexity underlying the mechanistic basis for the nucleic acid amplification, the technique is simple to use and the amplification and detection can be carried out in just one step...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28600575/altered-humoral-immunity-to-mycobacterial-antigens-in-japanese-patients-affected-by-inflammatory-demyelinating-diseases-of-the-central-nervous-system
#12
Davide Cossu, Kazumasa Yokoyama, Yuji Tomizawa, Eiichi Momotani, Nobutaka Hattori
Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium bovis (BCG) have been associated to several human autoimmune diseases such as multiple sclerosis (MS), but there are conflicting evidence on the issue. The objective of this study is to evaluate their role in Japanese patients affected by inflammatory demyelinating disorders of the central nervous system (IDDs). A total of 97 IDDs subjects including 51 MS and 46 neuromyelitis optica spectrum disorder (NMOSD) patients, and 34 healthy controls (HCs) were tested for the detection of IgG, IgM and IgA against mycobacterial antigens by indirect ELISA...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28599612/mycobacterioses-in-dogs-and-cats-from-buenos-aires-argentina
#13
Soledad Barandiaran, Marcela Martínez Vivot, Elvira Falzoni, María Jimena Marfil, Gabriela Pérez Tort, Paula Rovatti, Mónica Fernández, Ricardo Iachini, Fernanda Satek, Adriana Duchene, Martín José Zumárraga
Mycobacterioses can produce nonspecific clinical signs in dogs and cats that make diagnosis difficult. Furthermore, the full characterization of mycobacterial agents is not always possible or practical. We characterized mycobacteria detected through cytology in 12 dogs and 7 cats with generalized clinical signs from the province of Buenos Aires in Argentina. In dogs, molecular testing confirmed the presence of Mycobacterium avium subsp. hominissuis (MAH) in 8 cases and M. fortuitum in 1 case. All dogs were Miniature Schnauzers, suggesting that this breed may be more susceptible to M...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28592210/incidence-of-disseminated-mycobacterium-avium-complex-infection-in-hiv-patients-receiving-antiretroviral-therapy-with-use-of-mycobacterium-avium-complex-prophylaxis
#14
Younghee Jung, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Myoung-Don Oh
The incidence of disseminated Mycobacterium avium complex (MAC) infection in HIV patients has fallen markedly since the introduction of effective antiretroviral therapy (ART). However, current guidelines still recommend primary prophylaxis. We conducted a retrospective cohort study in a university-affiliated hospital from January 1998 to January 2014. During that period, HIV patients who had at least one CD4 cell count below 50 cells/mm(3) and had been treated with ART were enrolled. We compared incidence of disseminated MAC infection in the 12 months after the first CD4 cell count below 50 cells/mm(3) between prophylaxis and nonprophylaxis groups...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28588774/solitary-pulmonary-caseating-granulomas-a-5-year-retrospective-single-center-analysis
#15
Hidehiro Watanabe, Tomonori Uruma, Ikuo Seita, Tsuyoshi Oishi, Yusuke Watanabe, Ayaka Tsukimori, Yoshiteru Haga, Shinji Fukushima, Akihiro Sato, Itaru Nakamura, Tetsuya Matsumoto
Solitary pulmonary caseating granulomas (SPCGs) are a characteristic type of tuberculomas associated with infection with non-tuberculous mycobacteria (NTM) and other microbes; however, their significance remains unclear. The aim of the present study was to describe the clinical characteristics of patients with SPCGs in terms of diagnosis, presence of lung cancer and treatment status. A retrospective analysis of 17 immunocompetent patients with histopathologically confirmed caseating granulomas after undergoing video-assisted thoracoscopic surgery (VATS) was conducted at our center between 2011 and 2015...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28588573/bovine-wc1-and-wc1-neg-%C3%AE-%C3%AE-t-lymphocytes-influence-monocyte-differentiation-and-monocyte-derived-dendritic-cell-maturation-during-in-vitro-mycobacterium-avium-subspecies-paratuberculosis-infection
#16
Monica M Baquero, Brandon L Plattner
During early Mycobacterium avium subspecies paratuberculosis (Map) infection, complex interactions occur between the bacteria, cells from the mononuclear phagocyte system (MPS) including both resident (macrophages and dendritic cells) and recruited (monocytes) cells, and other mucosal sentinel cells such as γδ T lymphocytes. Though the details of early host-pathogen interactions in cattle remain largely underexplored, our hypothesis is that these significantly influence development of host immunity and ultimate success or failure of the host to respond to Map infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28582488/treatment-outcomes-of-mycobacterium-avium-complex-lung-disease-a-systematic-review-and-meta-analysis
#17
Nakwon Kwak, Jimyung Park, Eunyoung Kim, Chang-Hoon Lee, Sung Koo Han, Jae-Joon Yim
Background: The advent of macrolides has led to therapeutic advances in the treatment of Mycobacterium avium complex lung disease (MAC-LD). The aim of this study was to elucidate the treatment outcomes of macrolide-containing regimens. Methods: We performed a systematic review and meta-analysis of published studies reporting treatment outcomes of macrolide-containing regimens for MAC-LD using the MEDLINE, EMBASE, and Cochrane Library databases until 31 July 2016...
June 3, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28579973/conflicting-role-of-mycobacterium-species-in-multiple-sclerosis
#18
REVIEW
Davide Cossu, Kazumasa Yokoyama, Nobutaka Hattori
Mycobacterium is a genus of aerobic and acid-fast bacteria, which include several pathogenic organisms that cause serious diseases in mammals. Previous studies have associated the immune response against mycobacteria with multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system with unknown etiology. The role of mycobacteria in the pathological process has been controversial and often conflicting. We provide a detailed review of the mycobacteria that have been linked to MS over the last three decades, with a focus on Mycobacterium bovis bacille Calmette-Guérin vaccine for human and oral exposure to Mycobacterium avium subsp...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28578219/identification-of-new-antigen-candidates-for-the-early-diagnosis-of-mycobacterium-avium-subsp-paratuberculosis-infection-in-goats
#19
Armel Souriau, Sandrine Freret, Benjamin Foret, Peter T J Willemsen, Douwe Bakker, Laurence A Guilloteau
Currently Mycobacterium avium subsp. paratuberculosis (MAP) infection is diagnosed through indirect tests based on the immune response induced by the infection. The antigens commonly used in IFN-γ release assays (IGRA) are purified protein derivative tuberculins (PPD). However, PPDs, lack both specificity (Sp) and sensitivity (Se) in the early phase of infection. This study investigated the potential of 16 MAP recombinant proteins and five lipids to elicit the release of IFN-γ in goats from herds with or without a history of paratuberculosis...
May 26, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28573139/analysis-of-differentially-expressed-proteins-in-mycobacterium-avium-infected-macrophages-comparing-with-mycobacterium-tuberculosis-infected-macrophages
#20
Dongjun Yang, Xin Fu, Shiyi He, Xueping Ning, Min Ling
Mycobacterium avium (MA) belongs to the intracellular parasitic bacteria. To better understand how MA survives within macrophages and the different pathogenic mechanisms of MA and Mycobacterium tuberculosis (MTB), tandem mass tag (TMT) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis have been used to determine the proteins which are differentially expressed in MA-infected and MTB-infected macrophages. 369 proteins were found to be differentially expressed in MA-infected cells but not in MTB-infected cells...
2017: BioMed Research International
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