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JOURNAL ARTICLE
Jiaqi Zhang, Ying Tian, Xiangning Xu, Bicheng Wang, Ziqi Huang, Ke Song, Shuo Lou, Jingyi Kang, Ningning Zhang, Jingyu Li, Jing Weng, Yuanjing Liang, Wei Ma
PLD1 has been implicated in cytoskeletal reorganization and vesicle trafficking in somatic cells; however, its function remains unclear in oocyte meiosis. Herein, we found PLD1 stably expresses in mouse oocytes meiosis, with direct interaction with spindle, RAB11A+ vesicles and macroautophagic/autophagic vacuoles. The genetic or chemical inhibition of PLD1 disturbed MTOC clustering, spindle assembly and its cortical migration, also decreased PtdIns(4,5)P2 , phosphorylated CFL1 (p-CFL1 [Ser3]) and ACTR2, and their local distribution on MTOC, spindle and vesicles...
March 27, 2024: Autophagy
#2
JOURNAL ARTICLE
Pengfei Hao, Qiaoqiao Qu, Zhaoxia Pang, Letian Li, Shouwen Du, Limin Shang, Chaozhi Jin, Wang Xu, Zhuo Ha, Yuhang Jiang, Jing Chen, Zihan Gao, Ningyi Jin, Jian Wang, Chang Li
Rotavirus (RV) is an important zoonosis virus, which can cause severe diarrhea and extra-intestinal infection. To date, some proteins or carbohydrates have been shown to participate in the attachment or internalization of RV, including HGBAs, Hsc70, and integrins. This study attempted to indicate whether there were other proteins that would participate in the entry of RV; thus, the RV VP4-interacting proteins were identified by proximity labeling. After analysis and verification, it was found that VIM and ACTR2 could significantly promote the proliferation of RV in intestinal cells...
November 22, 2023: Journal of Virology
#3
JOURNAL ARTICLE
Maryam Ahmed S Al Barashdi, Ahlam Ali, Mary Frances McMullin, Ken Mills
Myeloid malignancies are a group of blood disorders characterized by the proliferation of one or more haematopoietic myeloid cell lineages, predominantly in the bone marrow, and are often caused by aberrant protein tyrosine kinase activity. The protein tyrosine phosphatase CD45 is a trans-membrane molecule expressed on all haemopoietic blood cells except that of platelets and red cells. CD45 regulates various cellular physiological processes including proliferation, apoptosis, and lymphocyte activation. However, its role in chemotherapy response is still unknown; therefore, the aim of this study was to investigate the role of CD45 in myeloid malignancies in terms of cellular growth, apoptosis, and response to chemotherapy...
November 2, 2023: Annals of Hematology
#4
JOURNAL ARTICLE
Xu He, Jiansong Fang, Mingli Gong, Juqi Zhang, Ran Xie, Dai Zhao, Yanlun Gu, Lingyue Ma, Xiaocong Pang, Yimin Cui
Pulmonary arterial hypertension (PAH) comprises a heterogeneous group of diseases with diverse aetiologies. It is characterized by increased pulmonary arterial pressure and right ventricular (RV) failure without specific drugs for treatment. Emerging evidence suggests that inflammation and autoimmune disorders are common features across all PAH phenotypes. This provides a novel idea to explore the characteristics of immunological disorders in PAH and identify immune-related genes or biomarkers for specific anti-remodelling regimens...
September 27, 2023: Journal of Cellular and Molecular Medicine
#5
JOURNAL ARTICLE
Hui Zhao, Lan Wang, Yi Yan, Qin-Hua Zhao, Jing He, Rong Jiang, Ci-Jun Luo, Hong-Ling Qiu, Yu-Qing Miao, Su-Gang Gong, Ping Yuan, Wen-Hui Wu
Pulmonary fibrosis (PF) and pulmonary hypertension (PH) have common pathophysiological features, such as the significant remodeling of pulmonary parenchyma and vascular wall. There is no effective specific drug in clinical treatment for these two diseases, resulting in a worse prognosis and higher mortality. This study aimed to screen the common key genes and immune characteristics of PF and PH by means of bioinformatics to find new common therapeutic targets. Expression profiles are downloaded from the Gene Expression Database...
2023: Frontiers in Immunology
#6
JOURNAL ARTICLE
Changqiang Wei, Yiyun Wei, Jinlian Cheng, Xuemei Tan, Zhuolin Zhou, Shanshan Lin, Lihong Pang
BACKGROUND: Recurrent pregnancy loss defined as the occurrence of two or more pregnancy losses before 20-24 weeks of gestation, is a prevalent and significant pathological condition that impacts human reproductive health. However, the underlying mechanism of RPL remains unclear. This study aimed to investigate the biomarkers and molecular mechanisms associated with RPL and explore novel treatment strategies for clinical applications. METHODS: The GEO database was utilized to retrieve the RPL gene expression profile GSE165004...
2023: Frontiers in Immunology
#7
JOURNAL ARTICLE
Wei-Zhou Wang, Xue Cao, Li Bian, Yue Gao, Ming Yu, Yi-Ting Li, Jian-Guo Xu, Yang-Hao Wang, He-Feng Yang, Ding-Yun You, Yong-Wen He
BACKGROUND: Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcinoma (OSCC). However, a lack of comprehensive molecular biological analysis leaves the regulatory mechanisms of CAFs-Exo in OSCC unclear. METHODS: We used platelet derived growth factor-BB (PDGF-BB) to induce the transformation of human oral mucosa fibroblast (hOMF) into CAFs, and extracted exosomes from the supernatant of CAFs and hOMF...
June 26, 2023: BMC Cancer
#8
JOURNAL ARTICLE
Liqian Yin, Yansheng Ding, Yang Wang, Chengdong Wang, Kuisheng Sun, Liquan Wang
BACKGROUND: MicroRNAs influence the growth and metastasis of breast cancer (BC) by regulating their target genes. Our study aims to screen and identify miRNAs that are closely related to the development of breast cancer, and explore the role of these miRNAs and their target genes in breast cancer. METHODS: Bioinformatics tools were applied to screen breast cancer-associated miRNAs and predict their potential target genes. Serum miRNAs were measured using RT-PCR...
2023: International Journal of General Medicine
#9
JOURNAL ARTICLE
Hao Yu Chen, Christian Dina, Aeron M Small, Christian M Shaffer, Rebecca T Levinson, Anna Helgadóttir, Romain Capoulade, Hans Markus Munter, Andreas Martinsson, Benjamin J Cairns, Linea C Trudsø, Mary Hoekstra, Hannah A Burr, Thomas W Marsh, Scott M Damrauer, Line Dufresne, Solena Le Scouarnec, David Messika-Zeitoun, Dilrini K Ranatunga, Rachel A Whitmer, Amélie Bonnefond, Garðar Sveinbjornsson, Ragnar Daníelsen, David O Arnar, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daníel F Gudbjartsson, Hilma Hólm, Jonas Ghouse, Morten Salling Olesen, Alex H Christensen, Susan Mikkelsen, Rikke Louise Jacobsen, Joseph Dowsett, Ole Birger Vesterager Pedersen, Christian Erikstrup, Sisse R Ostrowski, Christopher J O'Donnell, Matthew J Budoff, Vilmundur Gudnason, Wendy S Post, Jerome I Rotter, Mark Lathrop, Henning Bundgaard, Bengt Johansson, Johan Ljungberg, Ulf Näslund, Thierry Le Tourneau, J Gustav Smith, Quinn S Wells, Stefan Söderberg, Kári Stefánsson, Jean-Jacques Schott, Daniel J Rader, Robert Clarke, James C Engert, George Thanassoulis
AIMS: Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. METHODS AND RESULTS: A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10-8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2-SORT1, NLRP6, and SMC2...
April 11, 2023: European Heart Journal
#10
JOURNAL ARTICLE
Nai-Ning Wang, Yan Zhang, Feng Jiang, Dong-Li Zhu, Chen-Xi Di, Shou-Ye Hu, Xiao-Feng Chen, Li-Qiang Zhi, Yu Rong, Xin Ke, Yuan-Yuan Duan, Shan-Shan Dong, Tie-Lin Yang, Zhi Yang, Yan Guo
Genome-wide association studies (GWASs) have repeatedly reported multiple non-coding single-nucleotide polymorphisms (SNPs) at 2p14 associated with rheumatoid arthritis (RA), but their functional roles in the pathological mechanisms of RA remain to be explored. In this study, we integrated a series of bioinformatics and functional experiments and identified three intronic RA SNPs (rs1876518, rs268131, and rs2576923) within active enhancers that can regulate the expression of SPRED2 directly. At the same time, SPRED2 and ACTR2 influence each other as a positive feedback signal amplifier to strengthen the protective role in RA by inhibiting the migration and invasion of rheumatoid fibroblast-like synoviocytes (FLSs)...
April 6, 2023: American Journal of Human Genetics
#11
JOURNAL ARTICLE
Dandan Chen, Lili Jiang
This investigation mainly explores the roles of actin-related protein 2 (ACTR2) in diffuse large B-cell lymphoma (DLBCL). We first assessed the level of ACTR2 and its association with the overall survival (OS) of DLBCL. The results indicated that ACTR2 was upregulated in DLBCL and was associated with unfavorable prognosis of DLBCL. Next, the effect of ACTR2 knockdown or overexpression on DLBCL was evaluated in vitro . Our investigation revealed that ACTR2 depletion inhibited the malignant behaviors of DLBCL cells; whereas, ACTR2 abundance promoted those behaviors...
2022: Computational and Mathematical Methods in Medicine
#12
JOURNAL ARTICLE
Peiru Wei, Mingyou Dong, Yin Bi, Saiqiong Chen, Weiyu Huang, Ting Li, Bo Liu, Xiaoqian Fu, Yihua Yang
Recurrent miscarriage (RM) is a chronic, heterogeneous autoimmune disease that has serious social and personal consequences. No valid and reliable diagnostic markers or therapeutic targets for RM have been identified. Macrophages impact the innate immune system and can be used as diagnostic and prognostic markers for many diseases. We first collected 16 decidua and villi tissue samples from 5 normal patients and 3 RM patients for single-cell RNA sequencing data analysis and identified 1293 macrophage marker genes...
2022: Frontiers in Immunology
#13
JOURNAL ARTICLE
Jinpeng Zhuang, Jianing Zu, Changlong Zhou, Yi Sun, Pengyu Kong, Yongbin Jing
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) leads to significant morbidity. Other coadministered drugs may modulate the risk for BRONJ. The present study aimed to leverage bioinformatic data mining to identify drugs that potentially modulate the risk of BRONJ in cancer. Methods: A GEO gene expression dataset of peripheral blood mononuclear cells related to BRONJ in multiple myeloma patients was downloaded, and differentially expressed genes (DEGs) in patients with BRONJ versus those without BRONJ were identified...
2022: Disease Markers
#14
JOURNAL ARTICLE
Hua Fu, Ling Chu, Yi-Shu Yuan, Shan Liao, Guo-Hui Wang
Macrophages, associated with their heterogenous and dynamic polarization status, actively shape the development of renal fibrosis (RF). In this study, we revealed the significance of a signalling axis, circular RNA ACTR2 (circACTR2)/miR-200c/Yes-associated protein (YAP), in regulating macrophage polarization and the development of RF. A unilateral urethral obstruction (UUO)-induced RF model was established in vivo. In vitro, interferon-γ (IFNγ) and interleukin (IL)-4 were applied to induce M1 and M2 polarization, respectively...
August 4, 2022: Immunology
#15
JOURNAL ARTICLE
Mourad Zerfaoui, Koji Tsumagari, Eman Toraih, Youssef Errami, Emmanuelle Ruiz, Mohammed Sohail M Elaasar, Moroz Krzysztof, Andrew B Sholl, Sameh Magdeldin, Mohamed Soudy, Zakaria Y Abd Elmageed, A Hamid Boulares, Emad Kandil
The presence of mutant BRAF V600E correlates with the risk of recurrence in papillary thyroid cancer (PTC) patients. However, not all PTC patients with BRAF V600E are associated with poor prognosis. Thus, understanding the mechanisms by which certain PTC patients with nuclear BRAF V600E become aggressive and develop resistance to a selective BRAF inhibitor, PLX-4032, is urgently needed. The effect of nuclear localization of BRAFV600E using in vitro studies, xenograft mouse-model and human tissues was evaluated...
2022: American Journal of Cancer Research
#16
JOURNAL ARTICLE
Hanna Lucie Sladitschek-Martens, Alberto Guarnieri, Giulia Brumana, Francesca Zanconato, Giusy Battilana, Romy Lucon Xiccato, Tito Panciera, Mattia Forcato, Silvio Bicciato, Vincenza Guzzardo, Matteo Fassan, Lorenzo Ulliana, Alessandro Gandin, Claudio Tripodo, Marco Foiani, Giovanna Brusatin, Michelangelo Cordenonsi, Stefano Piccolo
Ageing is intimately connected to the induction of cell senescence1,2 , but why this is so remains poorly understood. A key challenge is the identification of pathways that normally suppress senescence, are lost during ageing and are functionally relevant to oppose ageing3 . Here we connected the structural and functional decline of ageing tissues to attenuated function of the master effectors of cellular mechanosignalling YAP and TAZ. YAP/TAZ activity declines during physiological ageing in stromal cells, and mimicking such decline through genetic inactivation of YAP/TAZ in these cells leads to accelerated ageing...
July 2022: Nature
#17
JOURNAL ARTICLE
Hua Fu, Yong-Hong Gu, Juan Tan, Ye-Ning Yang, Guo-Hui Wang
The crosstalk between macrophages and tubular epithelial cells (TECs) actively regulates the progression of renal fibrosis. In the present study, we revealed the significance of circular RNA ACTR2 (circACTR2) in regulating macrophage inflammation, epithelial-mesenchymal transition (EMT) of TECs, and the development of renal fibrosis. Our results showed UUO-induced renal fibrosis was associated with increased inflammation and EMT, hypertrophy of contralateral kidney, up-regulations of circACTR2 and NLRP3, and the down-regulation of miR-561...
April 21, 2022: Cellular and Molecular Life Sciences: CMLS
#18
JOURNAL ARTICLE
Mingyi Yang, Haishi Zheng, Yani Su, Ke Xu, Qiling Yuan, Yirixiati Aihaiti, Yongsong Cai, Peng Xu
Objective: Rheumatoid arthritis (RA) is a nonspecific, chronic, systemic autoimmune disease characterized by symmetric polyarticular synovitis. Bioinformatics analysis of potential biomarkers, mRNA-miRNA-lncRNA axes, and signaling pathways in the pathogenesis of RA provides potential targets and theoretical basis for further research on RA. Methods: The GSE1919 and GSE77298 datasets were downloaded from the Gene Expression Omnibus database (https://www.ncbi.nlm.nih...
2022: International Journal of General Medicine
#19
JOURNAL ARTICLE
Hong Zhou, Limei Wu, Lijun Yu, Yabing Yang, Lili Kong, Shuo Liu, Wenhui Chen, Ruiman Li
The DNA damage repair (DDR) genes are increasingly gaining attention as potential therapeutic targets in cancers. In this study, we identified the DDR genes associated with the tumor mutation burden (TMB) and prognosis of cervical squamous cell carcinoma (CESC) based on The Cancer Genome Atlas (TCGA) database. Through LASSO Cox regression, the prognostic signature involving five DDR genes (ACTR2, TEX12, UBE2V1, HSF1, and FBXO6) was established, and the risk score was identified as an independent risk factor for CESC...
2022: Journal of Oncology
#20
JOURNAL ARTICLE
Kenshiro Tabata, Akihiko Ishiyama, Yoko Nakamura, Masayuki Sasaki, Ken Inoue, Yu-Ichi Goto
Microdeletions encompassing the 2p14 region have been reported to cause a novel microdeletion syndrome, characterised by mild intellectual disability (ID) and language impairment (LI), usually showing no congenital malformations or severe dysmorphisms. Actin-related protein 2 (ACTR2) and Ras-related protein Rab-1A (RAB1A) genes present in this region have been suggested to be associated with ID and/or LI pathogenesis on the basis of a few singleton cases with 2p14 microdeletions, although the effects of other deleted genes could not be ruled out...
February 5, 2022: European Journal of Medical Genetics
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