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https://www.readbyqxmd.com/read/29329084/sources-of-polychlorinated-dibenzo-p-dioxins-and-dibenzofurans-and-biphenyls-in-chinese-mitten-crabs
#1
Ying Han, Wenbin Liu, Wen Zhu, Kaifeng Rao, Ke Xiao, Lirong Gao, Guijin Su, Guorui Liu
Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in Chinese mitten crabs from several areas were determined. The toxic equivalents (TEQs) for the mean PCDD/F and total PCDD/F and dioxin-like PCBs were 2.9 ± 2.7 and 5.7 ± 4.0 pg TEQ g-1, respectively. The mean concentrations of PCBs and dl-PCBs were 282 and 59 times the concentrations of PCDD/Fs, respectively. PCDD/F and PCB sources in the crab food web were assessed. The total TEQ of PCDD/F and PCB supplied by crab compound feed was 2...
January 6, 2018: Chemosphere
https://www.readbyqxmd.com/read/29324662/aryl-hydrocarbon-receptor-antagonists-mitigate-the-effects-of-dioxin-on-critical-cellular-functions-in-differentiating-human-osteoblast-like-cells
#2
Chawon Yun, Karina M Katchko, Michael S Schallmo, Soyeon Jeong, Jonghwa Yun, Charlotte H Chen, Joseph A Weiner, Christian Park, Andrew George, Samuel I Stupp, Wellington K Hsu, Erin L Hsu
The inhibition of bone healing in humans is a well-established effect associated with cigarette smoking, but the underlying mechanisms are still unclear. Recent work using animal cell lines have implicated the aryl hydrocarbon receptor (AhR) as a mediator of the anti-osteogenic effects of cigarette smoke, but the complexity of cigarette smoke mixtures makes understanding the mechanisms of action a major challenge. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) is a high-affinity AhR ligand that is frequently used to investigate biological processes impacted by AhR activation...
January 11, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29320557/high-ahr-expression-in-breast-tumors-correlates-with-expression-of-genes-from-several-signaling-pathways-namely-inflammation-and-endogenous-tryptophan-metabolism
#3
Sophie Vacher, Patrice Castagnet, Walid Chemlali, François Lallemand, Didier Meseure, Marc Pocard, Ivan Bieche, Martine Perrot-Applanat
Increasing epidemiological and animal experimental data provide substantial support for the role of aryl hydrocarbon receptor (AhR) in mammary tumorigenesis. The effects of AhR have been clearly demonstrated in rodent models of breast carcinogenesis and in several established human breast cancer cell lines following exposure to AhR ligands or AhR overexpression. However, relatively little is known about the role of AhR in human breast cancers. AhR has always been considered to be a regulator of toxic and carcinogenic responses to environmental contaminants such as TCDD (dioxin) and benzo[a]pyrene (BaP)...
2018: PloS One
https://www.readbyqxmd.com/read/29317249/mechanisms-of-2-3-7-8-tetrachlorodibenzo-p-dioxin-induced-cardiovascular-toxicity-an-overview
#4
REVIEW
Mahdieh Sadat Mohsenzadeh, Bamdad Riahi Zanjani, Gholamreza Karimi
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is an environmental contaminant and its toxicity is mediated by the aryl hydrocarbon receptor (AHR). Mechanisms of TCDD cardiovascular toxicity consist of oxidative stress, growth factor modulation, and ionic current alteration. It is indicated that the rodent cardiovascular system is a target for TCDD cardiomyopathy. Here, our understanding of TCDD cardiovascular toxicity is reviewed.
January 6, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29315775/expression-of-aryl-hydrocarbon-receptor-regulated-genes-and-superoxide-dismutase-in-the-antarctic-eelpout-pachycara-brachycephalum-exposed-to-benzo-a-pyrene
#5
Anneli Strobel, Felix C Mark, Helmut Segner, Patricia Burkhardt-Holm
The aryl hydrocarbon receptor (AHR) pathway mediates many, if not all, responses of fish to dioxin-like compounds. The Southern Ocean is progressively exposed to increasing concentrations of anthropogenic pollutants. Antarctic fish are known to accumulate those pollutants, yet nothing is known about their capability to induce chemical biotransformation via the AHR pathway. The objective of this study was to investigate if Antarctic eelpout, Pachycara brachycephalum, respond to anthropogenic pollutants by activation of the AHR and its target gene cytochrome P4501A (CYP1A), and of superoxide dismutase (SOD) which served as a representative for oxidative stress...
January 5, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29308921/understanding-the-toxic-potencies-of-xenobiotics-inducing-tcdd-tcdf-like-effects
#6
A D Şahin, M T Saçan
Toxic potencies of xenobiotics such as halogenated aromatic hydrocarbons inducing 2,3,7,8-tetrachlorodibenzo-p-dioxin/2,3,7,8-tetrachlorodibenzofuran (TCDD/TCDF)-like effects were investigated by quantitative structure-toxicity relationships (QSTR) using their aryl hydrocarbon receptor (AhR) binding affinity data. A descriptor pool was created using the SPARTAN 10, DRAGON 6.0 and ADMET 8.0 software packages, and the descriptors were selected using QSARINS (v.2.2.1) software. The QSTR models generated for AhR binding affinities of chemicals with TCDD/TCDF-like effects were internally and externally validated in line with the Organization of Economic Co-operation and Development (OECD) principles...
January 8, 2018: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29307304/molten-salt-oxidation-of-organic-hazardous-waste-with-high-salt-content
#7
Chengqian Lin, Yong Chi, Yuqi Jin, Xuguang Jiang, Alfons Buekens, Qi Zhang, Jian Chen
Organic hazardous waste often contains some salt, owing to the widespread use of alkali salts during industrial manufacturing processes. These salts cause complications during the treatment of this type of waste. Molten salt oxidation is a flameless, robust thermal process, with inherent capability of destroying the organic constituents of wastes, while retaining the inorganic ingredients in the molten salt. In the present study, molten salt oxidation is employed for treating a typical organic hazardous waste with a high content of alkali salts...
January 1, 2018: Waste Management & Research
https://www.readbyqxmd.com/read/29304501/effects-of-characteristics-of-waste-incinerator-on-emission-rate-of-halogenated-polycyclic-aromatic-hydrocarbon-into-environments
#8
Qi Wang, Yuichi Miyake, Masahiro Tokumura, Takashi Amagai, Yuichi Horii, Kiyoshi Nojiri, Nobutoshi Ohtsuka
We determined the concentrations of halogenated polycyclic aromatic hydrocarbons (XPAHs), some of which are carcinogenic and/or mutagenic compounds, in fly and bottom ashes and stack gas collected from waste incinerators in Japan. The dominant XPAHs in stack gas were consistent with those in the urban atmosphere. The dioxin-like toxic equivalent (TEQ) concentration ranges of the XPAHs in stack gas, fly ash, and bottom ash were 0.00497-20.5ng-TEQm-3, 0.0541-101ng-TEQg-1, and 0.000914-2.00ng-TEQg-1, respectively...
January 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29298861/hypersensitive-assessment-of-aryl-hydrocarbon-receptor-transcriptional-activity-using-a-novel-truncated-cyp1a-promoter-in-zebrafish
#9
Juan-Juan Luo, Dong-Sheng Su, Shao-Lin Xie, Yi Liu, Pei Liu, Xiao-Jun Yang, De-Sheng Pei
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent organic pollutant (POP), an unintentional byproduct of various industrial processes, and a human carcinogen. The expression of the cytochrome P450 1A (cyp1a) gene is upregulated in the presence of TCDD through activating the aryl hydrocarbon receptor pathway in a dose-dependent manner. Several essential response elements, including the 8 potential xenobiotic response elements in the cyp1a promoter region, have been identified to be the main functional parts for the response to TCDD...
January 3, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29290573/corrigendum-to-environmental-health-risk-assessment-of-dioxin-in-foods-at-the-two-most-severe-dioxin-hot-spots-in-vietnam-int-j-hyg-environ-health-218-2015-471-478
#10
Tran Thi Tuyet-Hanh, Nguyen Hung Minh, Le Vu-Anh, Michael Dunne, Leisa-Maree Toms, Thomas Tenkate, Minh-Hue Nguyen Thi, Fiona Harden
No abstract text is available yet for this article.
December 28, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/29289296/identification-of-differentially-expressed-genes-response-to-tcdd-in-rat-brain-after-long-term-low-dose-exposure
#11
Yangsheng Chen, Li Xu, Heidi Q H Xie, Tuan Xu, Hualing Fu, Songyan Zhang, Rui Sha, Yingjie Xia, Bin Zhao
Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose (0.1μg/(kg▪bw)) dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the differentially expressed genes...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29289289/airborne-pcdd-fs-in-two-e-waste-recycling-regions-after-stricter-environmental-regulations
#12
Manwen Zhang, Guixian Feng, Wenhua Yin, Bing Xie, Mingzhong Ren, Zhencheng Xu, Sukun Zhang, Zongwei Cai
Since the 2010s, the authorities of Guangdong province and local governments have enhanced law enforcement and environmental regulations to abolish open burning, acid washing, and other uncontrolled e-waste recycling activities. In this study, ambient air and indoor dust near different kinds of e-waste recycling processes were collected in Guiyu and Qingyuan to investigate the pollution status of particles and polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) after stricter environmental regulations. PM2...
December 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/29287387/field-investigation-to-determine-the-environmental-source-of-pcbs-in-a-pig-farm
#13
Vincent Vaccher, Philippe Marchand, Mélanie Picherot, Gaud Dervilly-Pinel, Elodie Lesquin, Aline Brosseaud, Anaïs Venisseau, Bruno Le Bizec
During a national monitoring plan, a pork fat sample was declared non-compliant for the sum of dioxins and PCB-DL (EU regulation). The National Reference Laboratory together with competent authorities conducted extended investigations to determine rapidly the contamination source at the farm level. A range of samples (n = 129), representative of potential contamination sources, was selected for further characterization (fat, feed, materials, dust, soil) and was analyzed for PCDD/Fs and DL-PCBs by GC-HRMS...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29287180/neurocognitive-and-physical-functioning-in-the-seveso-women-s-health-study
#14
Jennifer Ames, Marcella Warner, Paolo Brambilla, Paolo Mocarelli, William A Satariano, Brenda Eskenazi
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is neurotoxic in animals but few studies have investigated its effects on the human brain. Related dioxin-like compounds have been linked to poorer cognitive and motor function in older adults, with effects more pronounced in women, perhaps due to the loss of neuro-protective estrogen in menopause. On 10 July 1976, a chemical explosion in Seveso, Italy, resulted in one of the highest known residential exposures to TCDD. In 1996, we initiated the Seveso Women's Health Study, a retrospective cohort study of the health of the women who were newborn to 40 years old in 1976...
December 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/29285822/rapid-qualitative-analysis-of-two-flavonoids-rutin-and-silybin-in-medical-pills-by-direct-analysis-in-real-time-mass-spectrometry-dart-ms-combined-with-in-situ-derivatization
#15
Tibor Nagy, Ákos Kuki, Lajos Nagy, Miklós Zsuga, Sándor Kéki
Direct analysis in real time mass spectrometry (DART-MS) with in situ silylation was used for the rapid analysis of the flavonoids silybin ((2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin-6-yl]chroman-4-one) and rutin (quercetin-3-O-rutinoside). Three different derivatization reagents, hexamethyldisilazane/trimethylchlorosilane/pyridine (HMDS/TMCS/pyridine), N,O-bis(trimethylsilyl)acetamide/trimethylchlorosilane/N-trimethylsilyimidazole (BSA/TMCS/TMSI) and N,O-bis(trimethylsilyl)trifluoroacetamide/trimethylchlorosilane (BSTFA/TMCS), were applied...
December 29, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29283566/interaction-mode-and-regioselectivity-in-vitamin-b12-dependent-dehalogenation-of-aryl-halides-by-dehalococcoides-mccartyi-strain-cbdb1
#16
Shangwei Zhang, Lorenz Adrian, Gerrit Schüürmann
The bacterium Dehalococcoides, strain CBDB1, transforms aromatic halides through reductive dehalogenation. So far, however, the structures of its vitamin B12-containing dehalogenases are unknown, hampering clarification of the catalytic mechanism and substrate specificity as basis for targeted remediation strategies. This study employs a quantum chemical donor-acceptor approach for the Co(I)-substrate electron transfer. Computational characterization of the substrate electron affinity at carbon-halogen bonds enables discriminating aromatic halides ready for dehalogenation by strain CBDB1 (active substrates) from non-dehalogenated (inactive) counterparts with 92% accuracy, covering 86 of 93 bromobenzenes, chlorobenzenes, chlorophenols, chloroanilines, polychlorinated biphenyls, and dibenzo-p-dioxins...
December 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29281099/pretty-good-or-pretty-bad-the-ovary-and-chemicals-in-personal-care-products
#17
Zelieann R Craig, Ayelet Ziv-Gal
Personal care products (PCP) contain a myriad of chemicals generally formulated to provide a safe and beneficial use. Nonetheless, an increasing amount of laboratory animal and human studies indicate that some chemicals in PCP are associated with decreased hormone production, diminished ovarian reserve, ovarian cancer, and early pregnancy loss. The ovary is key to female fertility by providing the eggs and sex steroid hormones for fertilization and maintenance of reproductive function, respectively. Thus, understanding how chemicals in PCP affect the ovary will shed some light on their potential effects on female fertility...
December 21, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29277905/aryl-hydrocarbon-receptor-based-bioassays-for-dioxin-detection-thinking-outside-the-box
#18
REVIEW
Gaston Otarola, Hector Castillo, Sylvain Marcellini
Despite intensive media coverage and international regulations, man-made persistent organic pollutants such as dioxins represent a serious environmental and health threat. Their detection by sophisticated chromatography technologies is highly complex, impeding the constant monitoring of food or environmental samples. This limitation has fostered the development of generations of bioassays exploiting the molecular function of the aryl hydrocarbon receptor (AhR), which binds toxic compounds and directly activates the transcription of target genes...
December 26, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29277037/environmental-pollutant-hexachlorobenzene-induces-hypertension-in-a-rat-model
#19
Rocío Castilla, Agustín Asuaje, Stéphanie Rivière, Caimi Giselle Romero, Pedro Martín, Gabriel Cao, Diana Kleiman de Pisarev, Verónica Milesi, Laura Alvarez
Hexachlorobenzene (HCB) is a dioxin-like environmental pollutant, widely distributed in the environment. New research links exposure to high levels of persistent organic environmental toxicants to cardiovascular disease, however little is known about the effect of HCB on vascular function and on blood pressure. The purpose of the present study was to evaluate biochemical and cardiovascular changes resulting from subchronic HCB exposure. Adult female Sprague-Dawley rats were treated with vehicle or HCB (5 or 500 mg/kg b...
November 22, 2017: Chemosphere
https://www.readbyqxmd.com/read/29276959/biota-monitoring-under-the-water-framework-directive-on-tissue-choice-and-fish-species-selection
#20
Annette Fliedner, Heinz Rüdel, Nina Lohmann, Georgia Buchmeier, Jan Koschorreck
The study addresses the topic of suitable matrices for chemical analysis in fish monitoring and discusses the effects of data normalization in the context of the European Water Framework Directive (WFD). Differences between species are considered by comparing three frequently monitored species of different trophic levels, i.e., chub (Squalius cephalus, n = 28), (bream, Abramis brama, n = 11), and perch (Perca fluviatilis, n = 19) sampled in the German Danube. The WFD priority substances dioxins, furans and dioxin-like polychlorinated biphenyls (PCDD/F + dl-PCB), polybrominated diphenyl ethers (PBDE), α-hexabromocyclododecane (α-HBCDD), hexachlorobenzene (HCB), mercury (Hg), and perfluorooctane sulfonic acid (PFOS) as well as non-dioxin-like (ndl)-PCB were analyzed separately in fillet and carcass and whole body concentrations were calculated...
December 22, 2017: Environmental Pollution
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