keyword
MENU ▼
Read by QxMD icon Read
search

Dioxin

keyword
https://www.readbyqxmd.com/read/28648904/mixture-effects-of-30-environmental-contaminants-on-incident-metabolic-syndrome-a-prospective-study
#1
Lars Lind, Samira Salihovic, Erik Lampa, P Monica Lind
BACKGROUND: Several cross-sectional studies have linked different environmental contaminants to the metabolic syndrome (MetS). However, mixture effects have not been investigated and no prospective studies exist regarding environmental contaminants and the MetS. OBJECTIVES: To study mixture effects of contaminants on the risk of incident MetS in a prospective fashion. METHODS: Our sample consisted of 452 subjects from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (50% women, all aged 70years) free from the MetS at baseline, being followed for 10years...
June 22, 2017: Environment International
https://www.readbyqxmd.com/read/28648731/degradation-characteristics-of-dioxin-in-the-fly-ash-by-washing-and-ball-milling-treatment
#2
Baohua Li, Zhiyi Deng, Wenxiang Wang, Hongsheng Fang, Haibiao Zhou, Fangxin Deng, Ling Huang, Huiying Li
In this study, samples were taken from different types of municipal waste incineration plants in the Pearl River Delta, China. Analyzing the distributive characters of elements and dioxin congeners in fly ash, the method of washing-ball milling was utilized to remove chloride and degrade dioxin in fly ash. The results showed that more than 90% of particles were in the range of 1∼50μm and most of dioxin and metals existed in 0.030∼0.075mm of particles. K, Na, Cl and Br in fly ash could be removed by washing efficiently, however dioxin and other metals remained in the solid phase...
June 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28639323/molecular-interactions-of-dioxins-and-dlcs-with-the-xenosensors-pxr-and-car-an-in-silico-risk-assessment-approach
#3
Garima Verma, Mohemmed Faraz Khan, Mohammad Shaquiquzzaman, Wasim Akhtar, Mymoona Akhter, Syed Misbahul Hasan, Mohammad Mumtaz Alam
Dioxins and dioxin-like compounds (DLCs) are known to cause endocrine disruption in humans and animals. Being lipophilic xenobiotic chemicals, they can be easily absorbed into the biological system from the surrounding environments, thereby causing various health dysfunctions. In the present study, a total of 100 dioxins and DLCs were taken, and their binding pattern was assessed with the xenosensors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in comparison with the corresponding known inhibitors and a well-studied endocrine disrupting xenobiotic, bisphenol A (BPA)...
June 22, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28639016/accumulation-properties-of-polychlorinated-biphenyl-congeners-in-yusho-patients-and-prediction-of-their-cytochrome-p450-dependent-metabolism-by-in-silico-analysis
#4
Shusaku Hirakawa, Takashi Miyawaki, Tsuguhide Hori, Jumboku Kajiwara, Susumu Katsuki, Masashi Hirano, Yuka Yoshinouchi, Hisato Iwata, Chikage Mitoma, Masutaka Furue
In what has become known as the Yusho incident, thousands of people in western Japan were poisoned by the accidental ingestion of rice bran oil contaminated with polychlorinated biphenyls (PCBs) and various dioxins and dioxin-like compounds. In this study, we investigated the accumulation patterns of 69 PCB congeners in the blood of Yusho patients in comparison with those of non-exposed controls. The blood samples were collected at medical check-ups in 2004 and 2005. To compare the patterns of PCB congeners, we calculated the concentration ratio of each congener relative to the 2,2',4,4',5,5'-hexaCB (CB153) concentration...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28634910/the-complex-biology-of-the-aryl-hydrocarbon-receptor-and-its-role-in-the-pituitary-gland
#5
REVIEW
Robert Formosa, Josanne Vassallo
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes. Therefore, the AHR has been studied mostly in the context of xenobiotic signaling. However, several studies have shown that the AHR is constitutively active and plays an important role in general cell physiology, independently of its activity as a xenobiotic receptor and in the absence of exogenous ligands...
June 20, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/28633911/fate-of-metals-and-emissions-of-organic-pollutants-from-torrefaction-of-waste-wood-msw-and-rdf
#6
Mar Edo, Nils Skoglund, Qiuju Gao, Per-Erik Persson, Stina Jansson
Torrefaction of municipal solid waste (MSW), refuse-derived fuel (RDF), and demolition and construction wood (DC) was performed at 220°C and a residence time of 90min in a bench-scale reactor. The levels of toxic polychlorinated dibenzo-p-dioxins (PCDD) and dibenzofurans (PCDF) contained in emission from the torrefaction process were evaluated. In addition, main ash-forming elements and trace metals in the raw feedstock and char were determined. The use of MSW in fuel blends with DC resulted in lower PCDD and PCDF emissions after torrefaction, compared with the RDF blends...
June 17, 2017: Waste Management
https://www.readbyqxmd.com/read/28632453/survey-of-polychlorinated-dibenzo-p-dioxins-polychlorinated-dibenzofurans-and-non-ortho-polychlorinated-biphenyls-in-u-s-meat-and-poultry-from-2012-2013-toxic-equivalency-levels-patterns-temporal-trends-and-implications
#7
Sara J Lupton, Margaret O'Keefe, Jorge G Muñiz-Ortiz, Nelson Clinch, Pat Basu
The U.S. Department of Agriculture (USDA) conducts a statistically-based survey of the domestic meat supply (beef, pork, chicken, and turkey) to determine current levels of polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and non-ortho-polychlorinated biphenyls (no-PCBs) every five years. Fat samples for each slaughter class were collected from U.S. federally licensed slaughter facilities. The samples were processed and analyzed for 17 PCDD/Fs and 3 no-PCBs. The sum of PCDD, PCDF, and no-PCB toxic equivalencies (sum-TEQ) calculated using 2005 toxic equivalency factors for all slaughter classes, ranged from non-detect (nd) to 6...
June 20, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28621812/tcdd-induces-ubch7-expression-and-synphilin-1-protein-degradation-in-the-mouse-ventral-midbrain
#8
Emmanuel González-Barbosa, Alejandro Mejía-García, Elizabeth Bautista, Frank J Gonzalez, José Segovia, Guillermo Elizondo
UbcH7 is an ubiquitin-conjugating enzyme that interacts with parkin, an E3 ligase. The UbcH7-parkin complex promotes the ubiquitination and degradation of several proteins via the 26S proteasome. Cellular accumulation of the UbcH7-parkin targets alpha-synuclein, and synphilin-1 has been associated with Parkinson disease. In mouse liver, 2,3,7,8-tetrachlorodibenzo-p-dioxin, an aryl hydrocarbon receptor ligand, induces UbcH7 expression. Therefore, the aim of the present study was to determine whether 2,3,7,8-tetrachlorodibenzo-p-dioxin induces Ubch7 mRNA and UbcH7 protein expression in the mouse brain, to characterize the molecular mechanism, and the effect on synphilin-1 half-life...
June 16, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28621543/estimating-particulate-exposure-from-modern-municipal-waste-incinerators-in-great-britain
#9
Philippa Douglas, Anna Freni-Sterrantino, Maria Leal Sanchez, Danielle C Ashworth, Rebecca E Ghosh, Daniela Fecht, Anna Font, Marta Blangiardo, John Gulliver, Mireille B Toledano, Paul Elliott, Kees de Hoogh, Gary W Fuller, Anna L Hansell
Municipal Waste Incineration (MWI) is regulated through the European Union Directive on Industrial Emissions (IED), but there is ongoing public concern regarding potential hazards to health. Using dispersion modeling, we estimated spatial variability in PM10 concentrations arising from MWIs at postcodes (average 12 households) within 10 km of MWIs in Great Britain (GB) in 2003-2010. We also investigated change points in PM10 emissions in relation to introduction of EU Waste Incineration Directive (EU-WID) (subsequently transposed into IED) and correlations of PM10 with SO2, NOx, heavy metals, polychlorinated dibenzo-p-dioxins/furan (PCDD/F), polycyclic aromatic hydrocarbon (PAH) and polychlorinated biphenyl (PCB) emissions...
June 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28618207/effect-of-dioxin-and-17%C3%AE-estradiol-on-the-expression-of-cytochrome-p450-1a1-gene-via-an-estrogen-receptor-dependent-pathway-in-cellular-and-xenografted-models
#10
Ryeo-Eun Go, Kyung-A Hwang, Cho-Won Kim, Yong-Sub Byun, Ki-Hoan Nam, Kyung-Chul Choi
Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. Especially, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known as an agonist of AhR. In estrogen responsive cancers, 17β-estradiol (E2) may influence on AhR dependent expression of CYP1 family via the interaction between estrogen receptor (ER) and AhR. In the present study, the effect of E2/ER on the expression of AhR and CYP1A1 genes was investigated for MCF-7 clonal variant (MCF-7 CV) breast cancer cells expressing ER...
June 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28616149/is-iron-unique-in-promoting-electrical-conductivity-in-mofs
#11
Lei Sun, Christopher H Hendon, Sarah S Park, Yuri Tulchinsky, Ruomeng Wan, Fang Wang, Aron Walsh, Mircea Dincă
Identifying the metal ions that optimize charge transport and charge density in metal-organic frameworks is critical for systematic improvements in the electrical conductivity in these materials. In this work, we measure the electrical conductivity and activation energy for twenty different MOFs pertaining to four distinct structural families: M2(DOBDC)(DMF)2 (M = Mg(2+), Mn(2+), Fe(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+)); H4DOBDC = 2,5-dihydroxybenzene-1,4-dicarboxylic acid; DMF = N,N-dimethylformamide), M2(DSBDC)(DMF)2 (M = Mn(2+), Fe(2+); H4DSBDC = 2,5-disulfhydrylbenzene-1,4-dicarboxylic acid), M2Cl2(BTDD)(DMF)2 (M = Mn(2+), Fe(2+), Co(2+), Ni(2+); H2BTDD = bis(1H-1,2,3-triazolo[4,5-b],[4',5'-i]dibenzo[1,4]dioxin), and M(1,2,3-triazolate)2 (M = Mg(2+), Mn(2+), Fe(2+), Co(2+), Cu(2+), Zn(2+), Cd(2+))...
June 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28608896/cyclic-gas-phase-heterogeneous-process-in-a-metal-organic-framework-involving-a-nickel-nitrosyl-complex
#12
D Denysenko, D Volkmer
The cubic metal-organic framework MFU-4l ([Zn5Cl4(BTDD)3], H2-BTDD = bis(1H-1,2,3-triazolo[4,5-b],[4',5'-i])dibenzo[1,4]dioxin) featuring large pore apertures can be modified post-synthetically via partial or complete substitution of peripheral metal sites and chloride side-ligands, thus opening a route towards a large variety of functionalized MOFs. In this way, Ni-MFU-4l-nitrite (or Ni-MFU-4l-NO2) with an analytically determined chemical composition [Zn2.6Ni2.4(NO2)2.9Cl1.1(BTDD)3], containing accessible Ni-NO2 units, was prepared...
June 13, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28605331/classification-source-and-effect-of-environmental-pollutants-and-their-biodegradation
#13
REVIEW
Blessy Baby Mathew, Himani Singh, Vinai George Biju, N B Krishnamurthy
Any foreign chemical substance that is unusually present within an organism or is unexpectedly found in the environment at a higher concentration than the permissible limits can be termed a xenobiotic or a pollutant. Such substances include carcinogens, drugs, food additives, hydrocarbons, dioxins, polychlorinated biphenyls, pesticides or even some natural compounds. Pollutants are known for their higher persistence and pervasiveness, and along with their transformed products, they can remain in and interact with the environment for prolonged periods...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/28602820/structural-basis-for-aryl-hydrocarbon-receptor-mediated-gene-activation
#14
Kathrin Wiebke Schulte, Edward Green, Annabel Wilz, Michael Platten, Oliver Daumke
The aryl hydrocarbon receptor (AHR) and the AHR nuclear translocator (ARNT) constitute a heterodimeric basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain containing transcription factor with central functions in development and cellular homeostasis. AHR is activated by xenobiotics, notably dioxin, as well as by exogenous and endogenous metabolites. Modulation of AHR activity holds promise for the treatment of diseases featuring altered cellular homeostasis, such as cancer or autoimmune disorders. Here, we present the crystal structure of a heterodimeric AHR:ARNT complex containing the PAS A and bHLH domain bound to its target DNA...
May 30, 2017: Structure
https://www.readbyqxmd.com/read/28592194/2-3-4-4-5-pentachlorobiphenyl-impairs-insulin-induced-no-production-partly-through-excessive-ros-production-in-endothelial-cells
#15
Yang Long, Can Huang, Jian Wu, Jin-Nan Cheng, Guan-Nan Liang, Chun-Xia Jiang, Qin Wan
Polychlorinated biphenyls (PCBs) have been reported to be associated with increased risk to hypertension, atherosclerosis, cardiovascular disease, et al. 2,3',4,4',5-Pentachlorobiphenyl, known as PCB118, is a member of coplanar PCBs which renders their structure similar to polychlorinated dibenzo-p-dioxins (PCDDs) and has dioxin-like activity. In our current study, we investigated the effect of PCB118 exposure on nitric oxide (NO) production and the underlying mechanisms in vitro. Exposure of PCB 118 impaired insulin-induced NO production and endothelial nitric oxide synthase (eNOS) activity in human umbilical vein endothelial cells (HUVECs) with no significant effect on cell viability...
June 7, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28577146/historical-and-future-emission-of-hazardous-air-pollutants-haps-from-gas-fired-combustion-in-beijing-china
#16
Yifeng Xue, Lei Nie, Zhen Zhou, Hezhong Tian, Jing Yan, Xiaoqing Wu, Linglong Cheng
The consumption of natural gas in Beijing has increased in the past decade due to energy structure adjustments and air pollution abatement. In this study, an integrated emission inventory of hazardous air pollutants (HAPs) emitted from gas-fired combustion in Beijing was developed for the period from 2000 to 2014 using a technology-based approach. Future emission trends were projected through 2030 based on current energy-related and emission control policies. We found that emissions of primary HAPs exhibited an increasing trend with the rapid increase in natural gas consumption...
June 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28573564/effect-of-solid-waste-landfill-organic-pollutants-on-groundwater-in-three-areas-of-sicily-italy-characterized-by-different-vulnerability
#17
Serena Indelicato, Santino Orecchio, Giuseppe Avellone, Sergio Bellomo, Leopoldo Ceraulo, Rossella Di Leonardo, Vita Di Stefano, Rocco Favara, Esterina Gagliano Candela, Leonardo La Pica, Sabina Morici, Giovannella Pecoraino, Antonino Pisciotta, Claudio Scaletta, Fabio Vita, Salvatrice Vizzini, David Bongiorno
The aim of this study was to obtain information on the presence and levels of hazardous organic pollutants in groundwater located close to solid waste landfills. Eighty-two environmental contaminants, including 16 polycyclic aromatic hydrocarbons (PAHs), 20 volatile organic compounds (VOCs), 29 polychlorinated biphenyls (PCBs), 7 dioxins (polychlorinated dibenzo-p-dioxins, PCDDs) and 10 furans (polychlorinated dibenzofurans, PCDFs) were monitored in areas characterised by different geological environments surrounding three municipal solid waste landfills (Palermo, Siculiana and Ragusa) in Sicily (Italy) in three sampling campaigns...
June 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28573516/-persistent-organic-contaminants-in-food-exposure-hazard-potential-and-health-assessment
#18
REVIEW
Ulrike Pabel, Thorsten Buhrke, Klaus Abraham, Thilo Nölke, Matthias Gehling, Alfonso Lampen, Monika Lahrssen-Wiederholt, Reiner Wittkowski
Environmental emissions of organic contaminants are caused by man-made and natural combustion processes, industrial production facilities, and the release from products. Food represents the main source of human exposure for some of these compounds. This is the case for three groups of persistent organic contaminants: (1) per- and polyfluoroalkyl substances (PFAS), (2) polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs), and for (3) polycyclic aromatic hydrocarbons (PAHs)...
June 1, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28570974/photodegradation-of-micropollutants-using-v-uv-uv-c-processes-triclosan-as-a-model-compound
#19
Alfiya Yuval, Friedler Eran, Westphal Janin, Olsson Oliver, Dubowski Yael
Non-potable reuse of treated wastewater is becoming widespread as means to address growing water scarcity. Removal of micropollutants (MPs) from such water often requires advanced oxidation processes using OH radicals. OH can be generated in-situ via water photolysis under vacuum-UV (λ<200nm) irradiation. The aim of this study was to investigate the potential of unmasking V-UV radiation from low pressure Hg lamps (emitting at 185 and 254nm), commonly used in decentralized treatment systems, for enhancing MPs removal efficiency...
May 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28569646/mapping-exposure-to-multi-pollutants-using-environmental-biomonitors-a-multi-exposure-index
#20
Helena C Serrano, Melanie Köbel, José Palma-Oliveira, Pedro Pinho, Cristina Branquinho
Atmosphere is a major pathway for transport and deposition of pollutants in the environment. In industrial areas, organic compounds are released or formed as by-products, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F's). Inorganic chemical elements, including lead and arsenic, are also part of the pollutants mixture, and even in low concentrations may potentially be toxic and carcinogenic. However, assessing the spatial pattern of their deposition is difficult due to high spatial and temporal heterogeneity...
June 1, 2017: Journal of Toxicology and Environmental Health. Part A
keyword
keyword
21348
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"