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https://www.readbyqxmd.com/read/28544014/survey-on-the-presence-of-non-dioxine-like-pcbs-ndl-pcbs-in-loggerhead-turtles-caretta-caretta-stranded-in-south-mediterranean-coasts-sicily-southern-italy
#1
Gaetano Cammilleri, Enza Calvaruso, Licia Pantano, Giovanni Lo Cascio, Barbara Randisi, Andrea Macaluso, Mirella Vazzana, Giulia Caracappa, Giuseppe Giangrosso, Antonio Vella, Vincenzo Ferrantelli
A total of 71 loggerhead turtles (Caretta caretta) stranded along the coasts of Sicily (Southern Italy) were examined for Non Dioxine Like-PCB (NDL-PCB) levels in muscle and adipose tissue by a GC-MS/MS method. The results revealed high six indicator congeners (∑6 PCBIND ) levels in the 45% of the loggerhead turtles examined with mean values of 980.39 ± 2508.39 ng g(-1 ) w.w. in adipose tissue and 102.53 ± 238.58 ng g(-1 ) w.w. in muscle. The hexachloro and heptachloro PCB congeners were the most abundant in both the sample types...
May 23, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28540547/chlorinated-polycyclic-aromatic-hydrocarbons-in-surface-sediment-from-maowei-sea-guangxi-china-occurrence-distribution-and-source-apportionment
#2
Yu-Jie Wang, Ri-Quan Liao, Wen-Long Liu, Kurunthachalam Kannan, Takeshi Ohura, Ming-Hong Wu, Jing Ma
Chlorinated polycyclic aromatic hydrocarbons (ClPAHs) with three to five aromatic rings have been documented to ubiquitously occur in environmental matrices. In this study, residual concentrations and profiles of 20 individual ClPAHs were determined in 35 surface sediment samples from Maowei Sea, a semi-enclosed shallow inland bay located in the northwestern part of South China Sea. The concentrations of ΣClPAHs in sediment ranged from 313 to 9650 pg/g dw with a detection rate of 43-100%. Of the individual ClPAH congeners, 9-ClPhe was the most abundant in Maowei Sea with the concentrations that ranged from 99...
May 24, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28536913/histopathological-changes-in-zebrafish-embryos-exposed-to-dlpcbs-extract-from-zhanjiang-coastal-sediment
#3
Yunpeng Yu, Fanghong Nie, Anthony Hay, Hongying Lin, Yi Ma, Xianghong Ju, Dongliang Gong, Jinjun Chen, Ravi Gooneratne
Dioxin-like polychlorinated biphenyls (DLPCBs) are ubiquitous persistent pollutants that cause adverse effects in many environmental organisms. DLPCBs in marine sediments can be absorbed by benthic organisms, bioaccumulate, and biomagnify through the food chain and threaten animal and human health. There are no reports of DLPCBs concentrations in the Zhanjiang Gulf seabed. This study was designed to investigate the concentration of DLPCBs in the Zhanjiang coastal sediment and histopathological changes in zebrafish (Diano rerio) embryos exposed to environmentally relevant concentrations of DLPCBs...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28536482/nad-loss-a-new-player-in-ahr-biology-prevention-of-thymus-atrophy-and-hepatosteatosis-by-nad-repletion
#4
Silvia Diani-Moore, Jenny Shoots, Rubi Singh, Joshua B Zuk, Arleen B Rifkind
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a carcinogenic and highly toxic industrial byproduct that persists in the environment and produces a pleiotropic toxicity syndrome across vertebrate species that includes wasting, hepatosteatosis, and thymus atrophy. Dioxin toxicities require binding and activation of the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. However, after nearly 50 years of study, it remains unknown how AhR activation by dioxin produces toxic effects...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28533309/aryl-hydrocarbon-receptor-inhibition-promotes-hemato-lymphoid-development-from-human-pluripotent-stem-cells
#5
Mathew G Angelos, Paige N Ruh, Beau R Webber, Robert H Blum, Caitlin D Ryan, Laura Bendzick, Seonhui Shim, Ashley M Yingst, Dejene M Tufa, Michael R Verneris, Dan S Kaufman
The aryl hydrocarbon receptor (AHR) plays an important physiological role in hematopoiesis. AHR is highly expressed in hematopoietic stem/progenitor cells (HSPCs) and inhibition of AHR results in a marked expansion of human umbilical cord blood-derived HSPCs following cytokine stimulation. It is unknown whether AHR also contributes earlier in human hematopoietic development. To model hematopoiesis, human embryonic stem cells (hESCs) were allowed to differentiate in defined conditions in the presence of the AHR antagonist StemReginin-1 (SR-1) or AHR agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)...
May 22, 2017: Blood
https://www.readbyqxmd.com/read/28528419/a-risk-based-characterization-of-sediment-contamination-by-legacy-and-emergent-contaminants-of-concern-in-coastal-british-columbia-canada
#6
Carmen Morales-Caselles, Jean-Pierre W Desforges, Neil Dangerfield, Peter S Ross
Sediments have long been used to help describe pollution sources, contaminated sites, trends over time, and habitat quality for marine life. We collected surficial sediments from 12 sites at an average seawater depth of 25 m in three near-urban areas of the Salish Sea (British Columbia, Canada) to investigate habitat quality for marine life, including heavily contaminated killer whales. Samples were analyzed using high-resolution instrumentation for a wide variety of congeners of polychlorinated biphenyls (PCBs), polybrominated diphenylethers (PBDEs), hexabromocyclododecane (HBCDD), polybrominated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans, organochlorine pesticides, and polychlorinated naphthalenes (PCNs)...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28527750/estimating-serum-concentrations-of-dioxin-like-compounds-in-the-u-s-population-effective-2005-2006-and-2007-2008-a-multiple-imputation-and-trending-approach-incorporating-nhanes-pooled-sample-data
#7
Anne Bichteler, Daniele S Wikoff, Francis Loko, Mark A Harris
Dioxin-like compounds (DLCs) are monitored in the U.S. population using data collected with the National Health and Nutrition Examination Survey (NHANES). Until recently, participants' serum samples have been analyzed individually, and summary statistics defining reference ranges by age, gender, and race/ethnicity have served as the background by which other biomonitoring data can be evaluated. In the most recent NHANES DLC data, 2005-2006 and 2007-2008, participants' sera have been physically pooled prior to laboratory analysis, introducing major challenges to their utility as a reference population: variability among individuals and relations with covariates are lost, and individual design effects cannot be applied...
May 18, 2017: Environment International
https://www.readbyqxmd.com/read/28527418/atmospheric-pcdd-f-concentration-and-source-apportionment-in-typical-rural-agent-orange-hotspots-and-industrial-areas-in-vietnam
#8
Tuan Hung Ngo, To Thi Hien, Ngo Thi Thuan, Nguyen Hung Minh, Kai Hsien Chi
Vietnam has a double burden of dioxin from both industrial sources and historical sources. To evaluate the concentration of PCDD/Fs in ambient air in different areas of Vietnam and their possible sources, atmospheric samples were collected from three areas namely Son La (rural area) and Da Nang (harbor - Agent Orange hotspot area), and Ho Chi Minh City (metropolitan - industrial city). Vapor and solid phases of PCDD/Fs were collected and analyzed following the TO-9A sampling method. Principal Component Analysis and Positive Matrix Factorization model were applied to characterize the possible source...
May 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28514839/occurrence-of-brominated-dioxins-in-a-study-using-various-firefighting-methods
#9
Filip Bjurlid, Anna Kärrman, Niklas Ricklund, Jessika Hagberg
The use of different firefighting methods influences how fast a fire is extinguished and how fast the temperature drops in the area affected by the fire. These differences may also influence the formation of harmful pollutants during firefighting of an accidental fire. The aim was to study occurrence of brominated dibenzo-p-dioxins and furans (PBDD/Fs) in gas and soot during five fire scenarios resembling a small apartment fire and where different firefighting methods were used. Samples of gas and soot were taken both during the buildup of the fire and during the subsequent extinguishing of the fire while using different firefighting methods (nozzle, compressed air foam system, cutting extinguisher) and an extinguishing additive...
May 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28511039/occurrence-composition-source-and-regional-distribution-of-halogenated-flame-retardants-and-polybrominated-dibenzo-p-dioxin-dibenzofuran-in-the-soils-of-guiyu-china
#10
Pengjun Xu, Bu Tao, Zhiguang Zhou, Shuang Fan, Ting Zhang, Aimin Liu, Shuping Dong, Jingli Yuan, Hong Li, Jiping Chen, Yeru Huang
Guiyu, China, is well-known for the crude disposal of electronic waste (EW) and severe persistent organic pollutants (POPs). Therefore, in this study, the occurrence, composition, and source of polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB153), some novel brominated flame retardants (NBFRs), Dechlorane Plus (DP) and polybrominated dibenzo-p-dioxins/dibenzofurans (PBDD/Fs) in farmland soils covering Guiyu were studied. In EW disposal area soils, PBDEs were the most abundant FRs, with concentrations of 13-1014 ng g(-1)...
May 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28508954/-perceived-risks-of-food-contaminants
#11
REVIEW
Severine Koch, Mark Lohmann, Astrid Epp, Gaby-Fleur Böl
BACKGROUND: Food contaminants can pose a serious health threat. In order to carry out adequate risk communication measures, the subjective risk perception of the public must be taken into account. In this context, the breadth of the topic and insufficient terminological delimitations from residues and food additives make an elaborate explanation of the topic to consumers indispensable. A representative population survey used language adequate for lay people and a clear definition of contaminants to measure risk perceptions with regard to food contaminants among the general public...
May 16, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28508335/toxic-potential-of-organic-constituents-of-submicron-particulate-matter-pm1-in-an-urban-road-site-barcelona
#12
Sofia R Mesquita, Barend L van Drooge, Manuel Dall'Osto, Joan O Grimalt, Carlos Barata, Natividade Vieira, Laura Guimarães, Benjamin Piña
Atmospheric particulate matter (PM) is a recognized risk factor contributing to a number of diseases in human populations and wildlife globally. Organic matter is a major component of PM, but its contribution to overall toxicity of PM has not been thoroughly evaluated yet. In the present work, the biological activity of organic extracts from PM1 (particles with less than 1 μm of aerodynamic diameter) collected from an urban road site in the centre of Barcelona (NE Spain) was evaluated using a yeast-based assay (AhR-RYA) and different gene expression markers in zebrafish embryos...
May 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28508231/role-of-the-aryl-hydrocarbon-receptor-in-carcinogenesis-and-potential-as-an-anti-cancer-drug-target
#13
REVIEW
Siva Kumar Kolluri, Un-Ho Jin, Stephen Safe
The aryl hydrocarbon receptor (AhR) was initially identified as the receptor that binds and mediates the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and structurally related halogenated aromatics. Other toxic compounds including some polynuclear aromatic hydrocarbons act through the AhR; however, during the last 25 years, it has become apparent that the AhR plays an essential role in maintaining cellular homeostasis. Moreover, the scope of ligands that bind the AhR includes endogenous compounds such as multiple tryptophan metabolites, other endogenous biochemicals, pharmaceuticals and health-promoting phytochemicals including flavonoids, indole-3-carbinol and its metabolites...
May 15, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28501025/effects-of-unintentional-pcbs-in-pigments-and-chemical-products-on-transcriptional-activity-via-aryl-hydrocarbon-and-nuclear-hormone-receptors
#14
Shinji Takeuchi, Katsunori Anezaki, Hiroyuki Kojima
In recent years, some pigments and chemical products have been reported to contain polychlorinated biphenyl (PCB) congeners as unintentional byproducts, and these have also been detected in residential environments from indoor air and house dust. In this study, using in vitro reporter gene assays, we characterized the agonistic and antagonistic activities of a total of 25 PCB congeners contained in pigments (PCB-1 to -16, -20, -35, -40, -52, -56, -77, -101, -126, and -153) against five nuclear hormone receptors, (estrogen receptor (ER) α/β, glucocorticoid receptor (GR), androgen receptor (AR), thyroid hormone receptor (TR) α1) and aryl hydrocarbon receptor (AhR)...
May 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28498411/mitochondrial-activity-and-oxidative-stress-functions-are-influenced-by-the-activation-of-ahr-induced-cyp1a1-overexpression-in-cardiomyocytes
#15
Bing Zhou, Xi Wang, Feng Li, Yingting Wang, Lei Yang, Xiaolong Zhen, Wuhong Tan
There is an endemic cardiomyopathy currently occurring in China, termed, Keshan disease (KD). The authors previously compared mitochondrial‑associated gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from KD patients and normal controls, using mitochondria‑focused cDNA microarray technology. The results detected an upregulation of the enzyme‑associated CYP1A1 gene, (ratios ≥2.0). The aryl hydrocarbon receptor (AhR) regulates the expression of numerous cytochrome P450 (CYP) genes including members of the CYP1 family; CYP1A1 and CYP1A2...
May 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28490068/micropollutants-and-chemical-residues-in-organic-and-conventional-meat
#16
Gaud Dervilly-Pinel, Thierry Guérin, Brice Minvielle, Angélique Travel, Jérôme Normand, Marie Bourin, Eric Royer, Estelle Dubreil, Sophie Mompelat, Frédéric Hommet, Marina Nicolas, Vincent Hort, Chanthadary Inthavong, Mailie Saint-Hilaire, Claude Chafey, Julien Parinet, Ronan Cariou, Philippe Marchand, Bruno Le Bizec, Eric Verdon, Erwan Engel
The chemical contamination levels of both conventional and organic meats were assessed. The objective was to provide occurrence data in a context of chronic exposure. Environmental contaminants (17 polychlorinated dibenzodioxins/dibenzofurans, 18 polychlorinated biphenyls (PCBs), 3 hexabromocyclododecane (HBCD) isomers, 6 mycotoxins, 6 inorganic compounds) together with chemical residues arising from production inputs (75 antimicrobials, 10 coccidiostats and 121 pesticides) have been selected as relevant compounds...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28487818/modeling-adsorption-of-brominated-chlorinated-and-mixed-bromo-chloro-dibenzo-p-dioxins-on-c60-fullerene-using-nano-qspr
#17
Piotr Urbaszek, Agnieszka Gajewicz, Celina Sikorska, Maciej Haranczyk, Tomasz Puzyn
Many technological implementations in the field of nanotechnology have involved carbon nanomaterials, including fullerenes such as the buckminsterfullerene, C60. The unprecedented properties of such organic nanomaterials (in particular their large surface area) gained extensive attention for their potential use as organic pollutant sorbents. Sorption interactions can be very hazardous and useful at the same time. This work investigates the influence of halogenation by bromine and/or chlorine in dibenzo-p-dioxins on their sorption ability on the C60 fullerene surface...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28487374/dioxin-induced-increase-in-leukotriene-b4-biosynthesis-through-the-aryl-hydrocarbon-receptor-and-its-relevance-to-hepatotoxicity-owing-to-neutrophil-infiltration
#18
Tomoki Takeda, Yukiko Komiya, Takayuki Koga, Takumi Ishida, Yuji Ishii, Yasushi Kikuta, Michio Nakaya, Hitoshi Kurose, Takehiko Yokomizo, Takao Shimizu, Hiroshi Uchi, Masutaka Furue, Hideyuki Yamada
Dioxin and related chemicals alter the expression of a number of genes by activating the aryl hydrocarbon receptors (AHRs) to produce a variety of disorders including hepatotoxicity. However, it remains largely unknown how these changes in gene expression are linked to toxicity. To address this issue, we initially examined the effect of 2,3,7,8-tetrachrolodibenzo-p-dioxin (TCDD), a most toxic dioxin, on the hepatic and serum metabolome in male pubertal rats. The results obtained showed that TCDD causes many changes in the level of fatty acids, bile acids, amino acids and their metabolites...
May 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28486186/a-review-on-the-application-of-constructed-wetlands-for-the-removal-of-priority-substances-and-contaminants-of-emerging-concern-listed-in-recently-launched-eu-legislation
#19
REVIEW
Ana M Gorito, Ana R Ribeiro, C M R Almeida, Adrián M T Silva
The presence of organic pollutants in the aquatic environment, usually found at trace concentrations (i.e., between ng L(-1) and μg L(-1) or even lower, known as micropollutants), has been highlighted in recent decades as a worldwide environmental concern due to their difficult elimination by conventional water and wastewater treatment processes. The relevant information on constructed wetlands (CWs) and their application for the removal of a specific group of pollutants, 41 organic priority substances/classes of substances (PSs) and 8 certain other substances with environmental quality standards (EQS) listed in Directive 2013/39/EU as well as 17 contaminants of emerging concern (CECs) of the Watch List of Decision 2015/495/EU, is herein reviewed...
May 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28485586/conjugative-transfer-of-dioxin-catabolic-megaplasmids-and-bioaugmentation-prospects-of-a-rhodococcus-sp
#20
Jiao Sun, Yilun Qiu, Pengfei Ding, Peng Peng, Haiyan Yang, Li Li
Genetic bioaugmentation, in which bacteria harboring conjugative plasmids provide catabolic functions, is a promising strategy to restore dioxin-contaminated environments. Here we examined the conjugative transfer of the dioxin-catabolic plasmids pDF01 and pDF02 harbored by Rhodococcus sp. strain p52. A mating experiment was performed using strain p52 as a donor and a Pseudomonas aeruginosa strain as a recipient. The results showed that pDF01 and pDF02 were transferred concomitantly from strain p52 to the recipient strain at a conjugation frequency of 3×10(-)4 colonies per recipient...
May 9, 2017: Environmental Science & Technology
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