keyword
MENU ▼
Read by QxMD icon Read
search

Dioxin

keyword
https://www.readbyqxmd.com/read/29136567/persistent-organic-pollutants-in-red-and-white-blooded-high-antarctic-notothenioid-fish-from-the-remote-weddell-sea
#1
Anneli Strobel, Peter Schmid, Patricia Burkhardt-Holm, Helmut Segner, Markus Zennegg
It has been suggested that High-Antarctic waters, despite their remoteness from human activities, are impacted by anthropogenic pollution, and that the local biota are accumulating the contaminants. At present, no data exist on persistent organic pollutant (POP) body burdens for notothenioid fish inhabiting the High-Antarctic Weddell Sea. We determined the pollutant load in white muscle tissue of red- and white-blooded notothenoids from the Weddell Sea (Trematomus loennbergii and Chionodraco hamatus, respectively), and compared them to our previous measurements of POPs in Low-Antarctic notothenioids...
November 7, 2017: Chemosphere
https://www.readbyqxmd.com/read/29135489/endocrine-disrupters-and-pubertal-timing
#2
Louise C Greenspan, Mary M Lee
PURPOSE OF REVIEW: The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing. RECENT FINDINGS: In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty...
November 11, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/29128804/hexachlorobenzene-as-a-persistent-organic-pollutant-toxicity-and-molecular-mechanism-of-action
#3
REVIEW
Beata Starek-Świechowicz, Bogusława Budziszewska, Andrzej Starek
Hexachlorobenzene (HCB) is an organochlorine pesticide widely distributed in the environment. Chronic exposure of humans to HCB leads to a number of effects, such as triggering of porphyria, microsomal enzyme induction, thyroid dysfunctions, neurological symptoms, and immunological disorders. In animals, HCB induced hepatic porphyria, neurotoxic effects, and toxic effects on the thyroid function, reproductive system, and immune system. HCB as a dioxin-like compound and a weak ligand of the aryl hydrocarbon receptor (AhR) is a hormonal disruptor...
July 1, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29127834/comparison-of-chlordecone-and-ndl-pcb-decontamination-dynamics-in-growing-male-kids-after-cessation-of-oral-exposure-is-there-a-potential-to-decrease-the-body-levels-of-these-pollutants-by-dietary-supplementation-of-activated-carbon-or-paraffin-oil
#4
Marie-Laure Lastel, Agnès Fournier, Stefan Jurjanz, Jean-Pierre Thomé, Célia Joaquim-Justo, Harry Archimède, Maurice Mahieu, Cyril Feidt, Guido Rychen
Sixteen weaned male Alpine kids (Capra hircus) were subjected to a 21-day oral daily exposure of 0.05 mg kg(-1) BW. d(-1) of chlordecone (CLD) and 0.30 μg kg(-1) BW. d(-1) of each non-dioxin-like polychlorinated biphenyls (NDL-PCBs, congeners 28, 52, 101, 138, 153 and 180). Four kids, identified as the CONTA group, were slaughtered at the end of the exposure, while the remaining animals (n = 12) were fed with specific diets for an additional 21-day decontamination period before slaughtering. Kids from the DECONTA (n = 4) group were fed a control diet, while those from the AC10% and PO8% group received pellets supplemented with 10% activated carbon (AC) and 8% paraffin oil (PO), respectively...
October 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/29127629/identification-of-potential-aryl-hydrocarbon-receptor-ligands-by-virtual-screening-of-industrial-chemicals
#5
Malin Larsson, Domenico Fraccalvieri, C David Andersson, Laura Bonati, Anna Linusson, Patrik L Andersson
We have developed a virtual screening procedure to identify potential ligands to the aryl hydrocarbon receptor (AhR) among a set of industrial chemicals. AhR is a key target for dioxin-like compounds, which is related to these compounds' potential to induce cancer and a wide range of endocrine and immune system-related effects. The virtual screening procedure included an initial filtration aiming at identifying chemicals with structural similarities to 66 known AhR binders, followed by 3 enrichment methods run in parallel...
November 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29125581/occurrence-of-polychlorinated-dibenzo-p-dioxins-and-dibenzofurans-and-polychlorinated-biphenyls-in-fruit-and-vegetables-from-the-land-of-fires-area-of-southern-italy
#6
Mauro Esposito, Antonella De Roma, Stefania Cavallo, Gianfranco Diletti, Loredana Baldi, Giampiero Scortichini
The concentrations of polychlorinated dibenzo-p-concentrations dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) (PCDD/Fs), and polychlorinated biphenyls (PCBs) were determined in fruit and vegetables collected in farms located in the well-known "Land of Fires" area of Southern Italy, in an effort to learn more about the environmental pollution of this high-risk area due to illegal waste dumping and uncontrolled burning near cultivated fields. Concentrations were in the range 0.011-2.26 ng g(-1) for the six "indicator" non-dioxin-like PCBs (NDL-PCBs), and 0...
November 10, 2017: Toxics
https://www.readbyqxmd.com/read/29119490/influence-of-pyrolysis-temperature-and-production-unit-on-formation-of-selected-pahs-oxy-pahs-n-pacs-pcdds-and-pcdfs-in-biochar-a-screening-study
#7
Eva Weidemann, Wolfram Buss, Mar Edo, Ondřej Mašek, Stina Jansson
The influence of reactor type and operating conditions of the pyrolysis unit on the final concentration of toxic contaminants in biochar remains unclear. Therefore, we determined the concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs), nitrogen-containing polycyclic aromatic compounds (N-PACs), polychlorinated dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) in biochars produced from three different feedstocks (softwood, wheat straw, and anaerobic digestate)...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29112726/reconstructed-genomes-of-novel-dehalococcoides-mccartyi-strains-from-1-2-3-4-tetrachlorodibenzo-p-dioxin-dechlorinating-enrichment-cultures-reveal-divergent-reductive-dehalogenase-gene-profiles
#8
Hang T Dam, John Vollmers, Anne-Kristin Kaster, Max M Häggblom
Polychlorinated dibenzo-p-dioxin (PCDD) contaminated sites are widespread and associated with a variety of anthropogenic sources. PCDDs and other organohalide pollutants can serve as terminal electron acceptors for anaerobic respiration by specialized bacteria containing reductive dehalogenases (RdhA). These microorganisms, therefore, play an important role in bioremediation of PCDD contaminated sites. Two anaerobic enrichment cultures established using sediments collected from the PCDD polluted Hackensack (USA) and Kymijoki (Finland) rivers showed robust reductive dechlorination of 1,2,3,4-tetrachlorodibenzo-p-dioxin (1,2,3,4-TeCDD)...
November 3, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29111584/recent-applications-of-gc-with-high-resolution-ms
#9
REVIEW
Ivan Špánik, Andrea Machyňáková
Gas chromatography coupled to high-resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high-resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semi-volatile organic compounds. Gas chromatography with high-resolution mass spectrometry quantitative analyses were previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards...
November 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29109131/carbidopa-a-selective-ah-receptor-modulator-sahrm
#10
Stephen Safe
The aryl hydrocarbon receptor (AhR) was discovered as the intracellular receptor that bound with high affinity to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the AhR is required for mediating the toxicity induced by TCDD. Subsequent studies show that the AhR binds structurally diverse chemicals including plant-derived compounds that promote health and several AhR-active pharmaceuticals that exhibit anticancer activity. In this issue, there is a report that carbidopa, a drug used for treating Parkinson's disease, is also an AhR ligand, and this compound inhibits pancreatic cancer cell and tumor growth...
November 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29107893/lung-regeneration-after-toxic-injury-is-improved-in-absence-of-dioxin-receptor
#11
Antonio Morales-Hernández, Ana Nacarino-Palma, Nuria Moreno-Marín, Eva Barrasa, Beroé Paniagua-Quiñones, Inmaculada Catalina-Fernández, Alberto Alvarez-Barrientos, Xosé R Bustelo, Jaime M Merino, Pedro M Fernández-Salguero
Recent experimental evidences from cellular systems and from mammalian and non-mammalian animal models highlight novel functions for the aryl hydrocarbon/dioxin receptor (AhR) in maintaining cell differentiation and tissue homeostasis. Notably, AhR depletion stimulates an undifferentiated and pluripotent phenotype likely associated to a mesenchymal transition in epithelial cells and to increased primary tumorigenesis and metastasis in melanoma. In this work, we have used a lung model of epithelial regeneration to investigate whether AhR regulates proper tissue repair by adjusting the expansion of undifferentiated stem-like cells...
October 12, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29107582/perinatal-exposure-to-endocrine-disrupting-compounds-and-the-control-of-feeding-behavior-an-overview
#12
REVIEW
Sabrina N Walley, Troy A Roepke
Endocrine disrupting compounds (EDCs) are ubiquitous environmental contaminants that can interact with steroid and nuclear receptors or alter hormone production. Many studies have reported that perinatal exposure to EDC including bisphenol A, PCB, dioxins, and DDT disrupt energy balance, body weight, adiposity, or glucose homeostasis in rodent offspring. However, little information exists on the effects of perinatal EDC exposure on the control of feeding behaviors and meal pattern (size, frequency, duration), which may contribute to their obesogenic properties...
October 28, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29107226/the-fingerprint-nature-of-pcdd-in-iron-ore-sinter-strand-emissions-the-effect-of-suppressants-and-alternative-fuels-and-the-potential-for-comparison-with-the-isomer-profile-of-pcdf
#13
Tze C Ooi, Dennis Thompson, David R Anderson, Ray Fisher
It has been previously shown that the isomer profile of PCDF emissions from iron ore sinter plant only varies within limits even when suppressants or alternative fuels are added, to the extent that it can be said to have a 'fingerprint'. The isomer profiles of PCDD from tetra- to hexacholrodibenzo-p-dioxin from the same samples examined for PCDF emissions have been obtained, and show the same tendency for a 'fingerprint ' isomer distribution to occur. Occasional exceptionally high isomer abundances are observed, but these are uncommon...
October 19, 2017: Chemosphere
https://www.readbyqxmd.com/read/29100623/pathogenesis-of-deep-endometriosis
#14
REVIEW
Stephan Gordts, Philippe Koninckx, Ivo Brosens
The pathophysiology of (deep) endometriosis is still unclear. As originally suggested by Cullen, change the definition "deeper than 5 mm" to "adenomyosis externa." With the discovery of the old European literature on uterine bleeding in 5%-10% of the neonates and histologic evidence that the bleeding represents decidual shedding, it is postulated/hypothesized that endometrial stem/progenitor cells, implanted in the pelvic cavity after birth, may be at the origin of adolescent and even the occasionally premenarcheal pelvic endometriosis...
October 31, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29100482/equilibrium-model-analysis-of-waste-plastics-gasification-using-co2-and-steam
#15
P Kannan, G Lakshmanan, A Al Shoaibi, C Srinivasakannan
Utilization of carbon dioxide (CO2) in thermochemical treatment of waste plastics may significantly help to improve CO2 recycling, thus simultaneously curtailing dioxins/furans and CO2 emissions. Although CO2 is not such an effective gasifying agent as steam, a few investigations have explored the utilization of CO2 in conjunction with steam to achieve somewhat higher carbon conversion. This work presents a comparative evaluation study of CO2 and steam gasification of a typical post-consumer waste plastics mixture using an Aspen Plus equilibrium model...
November 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/29096953/pcdd-f-determination-in-sewage-sludge-composting-influence-of-aeration-and-the-presence-of-pcp
#16
Maria Muñoz, M Angeles Garrido, M Francisca Gomez-Rico, Rafael Font
Composting of sewage sludge is a common practice for sludge disposal. Some previous studies found high levels of polychorodibenzo-p-dioxins and polychorodibenzofurans (PCDD/Fs) after composting, especially octachlorodibenzo-p-dioxin (OCDD) but also 1234678-heptachlorodibenzo-p-dioxin (1234678-HpCDD) to a lesser extent. In this work, the concentrations of OCDD, 1234678-HpCDD and the rest of the 17 toxic congeners of PCDD/Fs were determined in compost obtained under different conditions. Although the toxicity of the two compounds mentioned above is small, their generation may reach undesirable levels...
October 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29096558/expression-of-aryl-hydrocarbon-receptor-inflammatory-cytokines-and-incidence-of-rheumatoid-arthritis-in-vietnamese-dioxin-exposed-people
#17
Chi Hung Nguyen, Taisuke Nakahama, Truong Tien Dang, Hoang Ha Chu, Luong Van Hoang, Tadamitsu Kishimoto, Nam Trung Nguyen
Many Vietnamese citizens have been and continue to be inadvertently exposed to dioxins and dioxin-like compounds deposited in the country during the Vietnam War. Dioxins may be involved in the pathogenesis of inflammatory diseases in part via by affecting expression of aryl hydrocarbon receptor (Ahr) and inflammatory cytokines in animal models. As the role of the Ahr in dioxin-exposed people is not well defined, a study was conducted to examine gene expression levels of Ahr, inflammatory cytokines, and the incidence of diseases in dioxin-exposed citizens who had/still resided near a heavily dioxin-contaminated area in Vietnam...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29093374/-molecular-mechanism-whereby-maternal-exposure-to-dioxin-suppresses-sexual-maturation-of-the-offspring-after-growing-up
#18
Tomoki Takeda
 Dioxins, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), are responsible for producing serious toxic effects in the next generation, such as sexual immaturity. Our laboratory found that treating pregnant rats on gestational day 15 with TCDD (1 μg/kg orally) targets pituitary luteinizing hormone (LH) to attenuate testicular steroidogenesis in fetuses. Because sex steroids during a short window ("the critical period") in the perinatal stage stimulate brain differentiation closely linked to sexual maturation, it is likely that TCDD imprints sexual immaturity on the offspring due to the lowered expression of LH during the fetal period...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29092071/the-regulation-mechanisms-of-ahr-by-molecular-chaperone-complex
#19
Ikuru Kudo, Miki Hosaka, Asami Haga, Noriko Tsuji, Yuhtaroh Nagata, Hirotaka Okada, Kana Fukuda, Yuka Kakizaki, Tomoya Okamoto, Ewa Grave, Hideaki Itoh
The AhR, so called the dioxin receptor, is a member of the nuclear receptor superfamily. The ligand-free AhR forms a cytosolic protein complex with the molecular chaperone HSP90, co-chaperone p23, and XAP2 in the cytoplasm. Following ligand binding like 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the AhR translocates into the nucleus. Although it has been reported that HSP90 regulates the translocation of the AhR to the nucleus, the precise activation mechanisms of the AhR have not yet been fully understood...
October 28, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/29091793/differential-sensitivities-to-dioxin-like-compounds-pcb-126-and-pecdf-between-tg-cyp1a-gfp-transgenic-medaka-and-zebrafish-larvae
#20
Hongyan Xu, Caixia Li, Pacharaporn Suklai, Qinghua Zeng, Raymond Chong, Zhiyuan Gong
It has been intensively documented that there are species-differences in the sensitivity to dioxin-like compounds (DLCs) in mammalian and avian. However, this issue is still unclear in fish. This study aimed at evaluating the differential sensitivities to DLCs in fish larvae. Here, larvae of Tg(cyp1a:gfp) medaka and Tg(cyp1a:gfp) zebrafish were tested with 2,3,7,8-Tetrachlorodibenzodioxin (TCDD), polychlorinated biphenyl 126 (PCB 126) and 2,3,4,7,8,-Pentachlorodibenzofuran (PeCDF). Comparative analyses were performed on induction of GFP fluorescence, expression of endogenous cyp1a mRNAs and EROD activity between the two species after exposure to these chemicals...
October 29, 2017: Chemosphere
keyword
keyword
21348
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"