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https://www.readbyqxmd.com/read/28447232/distribution-seasonal-variation-and-inhalation-risks-of-polychlorinated-dibenzo-p-dioxins-and-dibenzofurans-polychlorinated-biphenyls-and-polybrominated-diphenyl-ethers-in-the-atmosphere-of-beijing-china
#1
Yanfen Hao, Yingming Li, Thanh Wang, Yongbiao Hu, Huizhong Sun, Julius Matsiko, Shucheng Zheng, Pu Wang, Qinghua Zhang
Spatial distribution, seasonal variation and potential inhalation risks of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) were investigated in the atmosphere of Beijing, using passive air samplers equipped with polyurethane foam disks. Concentrations of ΣPCDD/Fs, ΣPCBs and ΣPBDEs ranged from 8.4 to 179 fg WHO2005-TEQ/m(3), 38.6-139 and 1.5-176 pg/m(3), respectively. PCDFs showed higher air concentrations than those of PCDDs, indicating the influence of industrial activities and other combustion processes...
April 26, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28441591/preliminary-study-of-possible-relationships-between-exposure-to-pcdd-fs-and-dl-pcbs-in-ambient-air-and-the-length-of-life-of-people
#2
Grzegorz Dziubanek, Ewa Marchwińska-Wyrwał, Małgorzata Ćwieląg-Drabek, Anna Spychała, Monika Rusin, Agata Piekut, Ilona Hajok
There is a lack of studies on the impact of very toxic and persistent organic compounds as polychlorinated dibenzodioxins (PCDDs), dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) on the population life expectancy. Preliminary studies on the relations between exposure to PCDD/Fs and dl-PCBs in ambient air and the length of life of residents of 12 cities (2 million people) in the Silesia province has been undertaken. The average length of life of inhabitants in 12 cities of Silesia province was calculated on the basis of register of deaths after excluding deaths caused by external causes and the concentration of PCDD/Fs and dl-PCBs were measured...
April 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28434239/pcb-126-effects-on-aryl-hydrocarbon-receptor-ubiquitin-and-p53-expression-levels-in-a-fish-product-sparus-aurata-l
#3
Calò Margherita, Bitto Alessandra, Lo Cascio Patrizia, Giarratana Filippo, Altavilla Domenica, Gervasi Teresa, Campone Luca, Cicero Nicola, Licata Patrizia
The aim of the present study is to determine if Ahr ligands as PCB-126, a dioxin-like, might contribute to inhibition of the tumour suppressor p53 by promoting its degradation through proteasome-ubiquitin system (UPS). The findings show, in the presence of PCB-126, a significant increase in p53 immunoreactivity in fish compared to the control. Subsequently, there is a decrease in p53 immunoreactivity at 24 h which is maintained even at 72 h. There is also a slight decrease in ubiquitin immunoreactivity to 12 h compared to the control and a marked decrease to 24 and 72 h...
April 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28433925/low-dose-pollutant-mixture-triggers-metabolic-disturbances-in-female-mice-leading-to-common-and-specific-features-as-compared-to-a-high-fat-diet
#4
Emmanuel Labaronne, Claudie Pinteur, Nathalie Vega, Sandra Pesenti, Benoit Julien, Emmanuelle Meugnier-Fouilloux, Hubert Vidal, Danielle Naville, Brigitte Le Magueresse-Battistoni
Environmental pollutants are potential etiologic factors of obesity and diabetes that reach epidemic proportions worldwide. However, it is important to determine if pollutants could exert metabolic defects without directly inducing obesity. The metabolic disturbances triggered in nonobese mice lifelong exposed to a mixture of low-dose pollutants (2,3,7,8-tetrachlorodibenzo-p-dioxine, polychlorinated biphenyl 153, diethylhexyl-phthalate, and bisphenol A) were compared with changes provoked by a high-fat high-sucrose (HFHS) diet not containing the pollutant mixture...
April 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28433708/toxicological-characterisation-of-two-novel-selective-aryl-hydrocarbon-receptor-modulators-in-sprague-dawley-rats
#5
Selma Mahiout, Jere Lindén, Javier Esteban, Ismael Sánchez-Pérez, Satu Sankari, Lars Pettersson, Helen Håkansson, Raimo Pohjanvirta
The aryl hydrocarbon receptor (AHR) mediates the toxicity of dioxins, but also plays important physiological roles. Selective AHR modulators, which elicit some effects imparted by this receptor without causing the marked toxicity of dioxins, are presently under intense scrutiny. Two novel such compounds are IMA-08401 (N-acetyl-N-phenyl-4-acetoxy-5-chloro-1,2-dihydro-1-methyl-2-oxo-quinoline-3-carboxamide) and IMA-07101 (N-acetyl-N-(4-trifluoromethylphenyl)-4-acetoxy-1,2-dihydro-5-methoxy-1-methyl-2-oxo-quinoline-3-carboxamide)...
April 19, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28432629/aquatic-photolysis-of-hydroxylated-polybromodiphenyl-ethers-under-direct-uv-irradiation-a-case-study-of-2-ho-bde-68
#6
Bentuo Xu, Minghong Wu, Chenyuan Pan, Yan Sun, Debao Yuan, Liang Tang, Gang Xu
Hydroxylated polyhalodiphenyl ethers (HO-PXDEs) have attracted considerable scientific interest as examples of emerging aquatic pollutants. However, a comprehensive assessment of disposal methods for this particular pollutant was seldom investigated. This study examined the UV light degradation of HO-PXDEs, using 2'-HO-2, 3', 4, 5'-tetrabromodiphenyl ether (2'-HO-BDE-68) as a case study. The results showed that UV light was superior to visible light and electron beam irradiation for producing a high degradation rate of 2'-HO-BDE-68...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28423456/progesterone-resistance-in-endometriosis-origins-consequences-and-interventions
#7
Bansari G Patel, Martin Rudnicki, Jie Yu, Yimin Shu, Robert N Taylor
Endometriosis is a common cause of pelvic pain and affects up to 10% of women of reproductive age. Aberrant progesterone signaling in the endometrium plays a significant role in impaired decidualization and establishment of ectopic endometrial implants. Eutopic endometrial cells from women with endometriosis fail to downregulate genes needed for decidualization, such as those involved in cell cycle regulation, leading to unbridled proliferation. Several causes of progesterone resistance in the endometrium have been postulated, including congenital "preconditioning", whereby the in utero environment renders infants susceptible to neonatal uterine bleeding and endometriosis...
April 19, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28422034/endocrine-disruptors-and-prostate-cancer
#8
Eduardo Sénchez de Badajoz, José Maria Lage-Sánchez, Pilar Sánchez-Gallegos
OBJECTIVES: Although prostate cancer is probably the most frequent cancer in men, little is known about its etiology. Clear evidence exists about variations in the incidence of prostate cancer between populations living in different countries. These variations could be explained by differences in lifestyle and a possible association with a set of substances that are able to intervene in the origin of the disease. METHODS: The reason that lifestyle may be the cause of prostate cancer is related to endocrine disruptors...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28421523/response-of-marine-benthic-fauna-to-thin-layer-capping-with-activated-carbon-in-a-large-scale-field-experiment-in-the-grenland-fjords-norway
#9
Göran S Samuelsson, Caroline Raymond, Stefan Agrenius, Morten Schaanning, Gerard Cornelissen, Jonas S Gunnarsson
A field experiment with thin-layer capping was conducted in the Grenland fjords, Norway, for remediation in situ of mercury and dioxin-contaminated sediments. Experimental fields at 30 and 95 m depth were capped with (i) powdered activated carbon (AC) mixed with clay (AC+cla`y), (ii) clay, and (iii) crushed limestone. Ecological effects on the benthic community and species-feeding guilds were studied 1 and 14 months after capping, and a total of 158 species were included in the analyses. The results show that clay and limestone had only minor effects on the benthic community, while AC+clay caused severe perturbations...
April 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28420543/serum-persistent-organic-pollutants-pops-and-prostate-cancer-risk-a-case-cohort-study
#10
Jung-Eun Lim, Chungmo Nam, Jiyeon Yang, Koon Ho Rha, Kyung-Min Lim, Sun Ha Jee
It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk. Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured...
April 10, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28416887/a-preliminary-study-of-pcbs-pahs-pesticides-and-trace-metals-contamination-in-cold-pressed-rapeseed-oils-from-conventional-and-ecological-cultivations
#11
Małgorzata Wroniak, Agnieszka Rękas
The purpose of this study was to investigate the levels of polycyclic aromatic hydrocarbons [benzo(a)anthracene, chrysene, benzo(b)fluoranthene, and benzo(a)pyrene], polychlorinated biphenyls (6 marker and 12 dioxin-like), pesticides (74 compounds) and heavy metals (Pb, Cd, As, Hg, Fe, Cu), in the cold-pressed rapeseed oils from conventional (RC) and ecological cultivations (RE). Similar level of PAHs, PCBs and heavy metals was found in the investigated cold-pressed oils; moreover, no effect of rapeseeds cultivation practice on the level of pesticide residues was found...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28413084/brominated-dioxins-furans-and-hydroxylated-polybrominated-diphenyl-ethers-occurrences-in-commercial-1-2-bis-2-4-6-tribromophenoxy-ethane-btbpe-and-2-4-6-tribromophenol-and-formation-during-synthesis-of-btbpe
#12
Man Ren, Hao Zeng, Ping-An Peng, Hui-Ru Li, Cai-Ming Tang, Jian-Fang Hu
Polybrominated dibenzo-p-dioxins (PBDDs) and hydroxylated polybrominated diphenyl ethers (OH-PBDEs) can be formed from bromophenols (BPs) by thermal degradation, biosynthesis or phototransformation. However, it is unknown whether PBDDs and OH-PBDEs can be formed during the chemical production processes that utilize BPs as raw materials. 2,4,6-tribromophenol (2,4,6-TBP) is an important raw material for the synthesis of 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), a novel brominated flame retardant. In this study, PBDDs, polybrominated dibenzofurans (PBDFs) and OH-PBDEs have been identified and quantified in commercially available BTBPE and 2,4,6-TBP...
April 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28412653/the-relationship-between-dioxins-exposure-and-risk-of-prostate-cancer-with-steroid-hormone-and-age-in-vietnamese-men
#13
Xian Liang Sun, Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni, Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le Ke Son
Although Vietnam's massive herbicide exposure in 1960s and 1970s was clearly injurious to health, not all causal relationships have been clarified. We therefore explored associations among dioxins, steroid hormones, age and prostate cancer risk in men. We compared serum levels of dioxin, steroid hormones and prostate specific antigen (PSA) in men aged 56-81years from herbicide-exposed hotspots (n=50) with those from non-sprayed regions (n=48). Mean serum levels of dioxin congeners in the hotspot group were 1...
April 13, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28405246/modulation-of-benzo-a-pyrene-dna-adduct-formation-by-cyp1-inducer-and-inhibitor
#14
REVIEW
Kazuhiro Shiizaki, Masanobu Kawanishi, Takashi Yagi
Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA adducts. This enzyme is strongly induced by many different chemical agents, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which binds to the aryl hydrocarbon receptor (AhR). Therefore, AhR activators are suspected to have the potential to aggravate the toxicity of BaP through the induction of CYP1A1...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28403572/development-and-application-of-a-probabilistic-risk-benefit-assessment-model-for-infant-feeding-integrating-microbiological-nutritional-and-chemical-components
#15
Géraldine Boué, Enda Cummins, Sandrine Guillou, Jean-Philippe Antignac, Bruno Le Bizec, Jeanne-Marie Membré
A probabilistic and interdisciplinary risk-benefit assessment (RBA) model integrating microbiological, nutritional, and chemical components was developed for infant milk, with the objective of predicting the health impact of different scenarios of consumption. Infant feeding is a particular concern of interest in RBA as breast milk and powder infant formula have both been associated with risks and benefits related to chemicals, bacteria, and nutrients, hence the model considers these three facets. Cronobacter sakazakii, dioxin-like polychlorinated biphenyls (dl-PCB), and docosahexaenoic acid (DHA) were three risk/benefit factors selected as key issues in microbiology, chemistry, and nutrition, respectively...
April 12, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28402200/elimination-of-dioxins-in-milk-by-dairy-cows-after-the-long-term-intake-of-contaminated-sugar-beet-pellets
#16
Jadwiga Piskorska-Pliszczynska, Sebastian Maszewski, Szczepan Mikolajczyk, Marek Pajurek, Pawel Strucinski, Marek Olszowy
Dried feed materials, such as sugar beet pellets, may be a source of high levels of PCDD/Fs. The studies followed up dioxin congener elimination from contaminated milk (5.02 ± 1.39 pg WHO PCDD/F-PCBs-TEQ g(-1) fat) up to 338 days after withdrawal of polluted feed ingredient (4.37 ± 0.25 ng PCDD/F/DL-PCBs-TEQ kg(-1) feed). The main objectives of the study were to estimate the length of the time needed to achieve an acceptable PCDD/F milk level as set by European Union law, to track the fate of the PCDD/F congeners, and to assess the potential risk for consumers associated with long-term consumption of contaminated milk...
April 12, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28399455/dioxins-degradation-and-reformation-during-mechanochemical-treatment
#17
Zhiliang Chen, Qiongjing Mao, Shengyong Lu, Alfons Buekens, Shuaixi Xu, Xu Wang, Jianhua Yan
Mechanochemical dechlorination and destruction of polychlorinated dibenzo-p-dioxins and -furans (PCDD/F) on fly ash from Municipal Solid Waste Incineration was tested with and without additives (CaO and CaO/aluminium powder). The first results disappointed because of obvious PCDD/F-reformation and a second test series was conducted after removing soluble salts (NaCl, KCl …) by thorough two-stage water washing. This second test series was successful and demonstrated good destruction results, especially with combined CaO/aluminium powder as additive...
April 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28397117/pcdd-f-formation-during-thermal-desorption-of-p-p-ddt-contaminated-soil
#18
Zhonghua Zhao, Mingjiang Ni, Xiaodong Li, Alfons Buekens, Jianhua Yan
Thermal treatment of polychlorinated biphenyls (PCB) contaminated soil was shown in earlier work to generate polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF). In this study, the PCDD/F were studied arising during the remediation of p,p'-DDT contaminated soil by thermal desorption. Three kinds of soil (sandy, clayey and lateritic soil) were tested to investigate the effect of soil texture on PCDD/F formation. Those soils were artificially polluted with p,p'-DDT, obtaining a concentration level of 100 mg/kg...
April 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28396409/structural-hierarchy-controlling-dimerization-and-target-dna-recognition-in-the-ahr-transcriptional-complex
#19
Seung-Hyeon Seok, Woojong Lee, Li Jiang, Kaivalya Molugu, Aiping Zheng, Yitong Li, Sanghyun Park, Christopher A Bradfield, Yongna Xing
The aryl hydrocarbon receptor (AHR) belongs to the PAS (PER-ARNT-SIM) family transcription factors and mediates broad responses to numerous environmental pollutants and cellular metabolites, modulating diverse biological processes from adaptive metabolism, acute toxicity, to normal physiology of vascular and immune systems. The AHR forms a transcriptionally active heterodimer with ARNT (AHR nuclear translocator), which recognizes the dioxin response element (DRE) in the promoter of downstream genes. We determined the crystal structure of the mammalian AHR-ARNT heterodimer in complex with the DRE, in which ARNT curls around AHR into a highly intertwined asymmetric architecture, with extensive heterodimerization interfaces and AHR interdomain interactions...
April 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28391935/gas-phase-and-particle-phase-pcdd-f-congener-distributions-in-the-flue-gas-from-an-iron-ore-sintering-plant
#20
Xiaolong Liu, Meng Ye, Xue Wang, Wen Liu, Tingyu Zhu
The activated carbon injection-circulating fluidized bed (ACI-CFB)-bag filter coupling technique was studied in an iron ore sintering plant. For comparison, the removal efficiencies under the conditions without or with ACI technology were both evaluated. It was found that the polychlorinated dibenzo-p-dioxins and dibenzofuran (PCDD/F) removal efficiency for total international toxic equivalence quantity (I-TEQ) concentration was improved from 91.61% to 97.36% when ACI was employed, revealing that ACI was very conducive to further controlling the PCDD/F emissions...
April 2017: Journal of Environmental Sciences (China)
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