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https://www.readbyqxmd.com/read/27932487/mortality-risk-among-workers-with-exposure-to-dioxins
#1
J J Collins, K M Bodner, L L Aylward, T J Bender, S Anteau, M Wilken, C M Bodnar
BACKGROUND: In several studies, dioxin exposure has been associated with increased risk from several causes of death. AIMS: To compare the mortality experience of workers exposed to dioxins during trichlorophenol (TCP) and pentachlorophenol (PCP) production to that of the general population and to examine mortality risk by estimated exposure levels. METHODS: A retrospective cohort study which followed up workers' vital status from 1940 to 2011, with serum surveys to support estimation of historical dioxin exposure levels...
December 7, 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27928942/occurrence-of-polychlorinated-dibenzo-p-dioxins-pcdds-dibenzofurans-pcdfs-and-polychlorinated-biphenyls-pcbs-in-eggs-from-free-range-hens-in-campania-southern-italy-and-risk-evaluation
#2
Sara Lambiase, Francesco Paolo Serpe, Stefania Cavallo, Guido Rosato, Loredana Baldi, Bruno Neri, Mauro Esposito
Hens' eggs collected in home-producing farms located in different areas of the Campania region of southern Italy were analysed for six NDL-polychlorobiphenyls (PCB indicators), 17 polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs), and 12 congeners of dioxin-like PCBs (DL-PCBs). In the investigated area, waste from civil, industrial and hospital activities was illegally dumped and in many cases burned, so the area is called the 'Land of fire'. This illicit practice has been considered the main source of pollution in this territory and the cause of the persistent organic pollutants' (POPs) contamination in the neighbouring lands intended for agricultural use and livestock...
December 8, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27928578/reporter-gene-assays-in-ecotoxicology
#3
Tal Elad, Shimshon Belkin
The need for simple and rapid means for evaluating the potential toxic effects of environmental samples has prompted the development of reporter gene assays, based on tester cells (bioreporters) genetically engineered to report on sample toxicity by producing a readily quantifiable signal. Bacteria are especially suitable to serve as bioreporters owing to their fast responses, low cost, convenient preservation, ease of handling, and amenability to genetic manipulations. Various bacterial bioreporters have been introduced for general toxicity and genotoxicity assessment, and the monitoring of endocrine disrupting and dioxin-like compounds has been mostly covered by similarly engineered eukaryotic cells...
December 8, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27919152/-monitoring-plan-of-environmental-contaminants-in-sheep-milk-from-areas-next-to-an-italian-contaminated-site-named-%C3%A2-aree-industriali-di-porto-torres-e-discarica-di-calancoi%C3%A2-industrial-areas-of-porto-torres-and-landfill-of-calancoi-in-sardinia-region-southern
#4
Francesco Sgarangella, Giuseppe Bitti, Maria Caterina Suelzu, Pietro Desini, Patrizia Piras, Gianuario Fiori, Maurizio Cossu, Giannina Chessa
OBJECTIVES: to assess concentration levels of dioxins, PCBs, and chemical elements in sheep milk produced in areas close to the Italian contaminated site (CS) located in the North-West of Sardinia (Southern Italy), named «Aree industriali di Porto Torres e discarica di Calancoi» (i.e., industrial areas of Porto Torres and landfill of Calancoi). DESIGN: monitoring plan of environmental contaminants on zootechnical productions based on analysis of dioxins, PCBs, heavy metals (Cd, Hg, Pb), and other elements (As, Be, Cr, Ni, Tl , Zn) in sheep bulk milk...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27913140/comparative-analysis-of-tcdd-induced-ahr-mediated-gene-expression-in-human-mouse-and-rat-primary-b-cells
#5
Natalia Kovalova, Rance Nault, Robert Crawford, Timothy R Zacharewski, Norbert E Kaminski
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent environmental pollutant that activates the aryl hydrocarbon receptor (AhR) resulting in altered gene expression. In vivo, in vitro, and ex vivo studies have demonstrated that B cells are directly impaired by TCDD, and are a sensitive target as evidenced by suppression of antibody responses. The window of sensitivity to TCDD-induced suppression of IgM secretion among mouse, rat and human B cells is similar. Specifically, TCDD must be present within the initial 12h post B cell stimulation, indicating that TCDD disrupts early signaling network(s) necessary for B lymphocyte activation and differentiation...
November 29, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27913019/persistent-organic-pollutants-in-shallow-percolated-water-of-the-alps-karst-system-zugspitze-summit-germany
#6
Walkiria Levy, Marchela Pandelova, Bernhard Henkelmann, Silke Bernhöft, Norbert Fischer, Felix Antritter, Karl-Werner Schramm
In the German Calcareous Alps at the Zugspitze, percolated water close to a permafrost bedrock in a tunnel system was monitored long-term for polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), polychlorinated biphenyls (PCB), polycyclic aromatic hydrocarbons (PAH), and 28 organochlorine pesticides (OCP). Semi-permeable membrane devices (SPMD) were deployed in a temporary surface water system at the Zugspitze plateau and analysed for PCB, PAH, and OCP. The high-volume water sampling was successfully implemented and all compounds were identified in the water percolated through the Karst system...
November 30, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27909210/a-full-scale-study-on-thermal-degradation-of-polychlorinated-dibenzo-p-dioxins-and-dibenzofurans-in-municipal-solid-waste-incinerator-fly-ash-and-its-secondary-air-pollution-control-in-china
#7
Xingbao Gao, Bingjing Ji, Dahai Yan, Qifei Huang, Xuemei Zhu
Degradation of polychlorinated dibenzo-p-dioxins and dibenzofurans in municipal solid waste incinerator fly ash is beneficial to its risk control. Fly ash was treated in a full-scale thermal degradation system (capacity 1 t d(-1)) to remove polychlorinated dibenzo-p-dioxins and dibenzofurans. Apart from the confirmation of the polychlorinated dibenzo-p-dioxin and dibenzofuran decomposition efficiency, we focused on two major issues that are the major obstacles for commercialising this decomposition technology in China, desorption and regeneration of dioxins and control of secondary air pollution...
November 30, 2016: Waste Management & Research
https://www.readbyqxmd.com/read/27907097/levels-of-selected-persistent-organic-pollutants-pcb-pbde-and-pesticides-in-honey-bee-pollen-sampled-in-poland
#8
Marek Łukasz Roszko, Marta Kamińska, Krystyna Szymczyk, Renata Jędrzejczak
Chemical plant protection is a commonly discussed factor potentially responsible for decline in pollinators and other beneficial insect populations. Various groups of chemicals including persistent organic pollutants could impact a bee colony's welfare and are reported to be present in bee tissue and apiary products. The aim of this work was to evaluate the presence of selected persistent organic pollutant and pesticide residues in bee pollen originating from different geographical regions of Poland. Pesticide residues were identified in 60% of tested bee pollen samples...
2016: PloS One
https://www.readbyqxmd.com/read/27899901/association-of-aryl-hydrocarbon-receptor-related-gene-variants-with-the-severity-of-autism-spectrum-disorders
#9
Takashi X Fujisawa, Shota Nishitani, Ryoichiro Iwanaga, Junko Matsuzaki, Chisato Kawasaki, Mamoru Tochigi, Tsukasa Sasaki, Nobumasa Kato, Kazuyuki Shinohara
Exposure to environmental chemicals, such as dioxin, is known to have adverse effects on the homeostasis of gonadal steroids, thereby potentially altering the sexual differentiation of the brain to express autistic traits. Dioxin-like chemicals act on the aryl hydrocarbon receptor (AhR), polymorphisms, and mutations of AhR-related gene may exert pathological influences on sexual differentiation of the brain, causing autistic traits. To ascertain the relationship between AhR-related gene polymorphisms and autism susceptibility, we identified genotypes of them in patients and controls and determined whether there are different gene and genotype distributions between both groups...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27897234/association-between-dioxin-and-cancer-incidence-and-mortality-a-meta-analysis
#10
Jinming Xu, Yao Ye, Fang Huang, Hanwen Chen, Han Wu, Jian Huang, Jian Hu, Dajing Xia, Yihua Wu
The objective of the present study was to systematically assess the association between dioxin/2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and cancer incidence and mortality. Systematic literature searches were conducted until July 2015 in Pubmed, Embase and Cochrane library to identify relevant studies. A random-effects model was applied to estimate the pooled odds ratio (OR), risk ratio (RR), standard incidence ratio (SIR) or standard mortality ratio (SMR) for cancer incidence or mortality. In addition, dose-response, meta-regression, subgroup, and publication bias analyses were conducted...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27894695/the-performance-of-atmospheric-pressure-gas-chromatography-tandem-mass-spectrometry-compared-to-gas-chromatography-high-resolution-mass-spectrometry-for-the-analysis-of-polychlorinated-dioxins-and-pcbs-in-food-and-feed-samples
#11
Guillaume Ten Dam, Igor Cabreira Pussente, Georges Scholl, Gauthier Eppe, Alexander Schaechtele, Stefan van Leeuwen
Recently, gas chromatography tandem mass spectrometry (GC-MS/MS) has been added in European Union (EU) legislation as an alternative to magnetic sector high resolution mass spectrometry (HRMS) for the analysis of dioxins and dioxin like polychlorinated biphenyls (dl-PCB) in food and feed. In this study the performance of APGC-MS/MS compared to GC-HRMS is investigated and compared with EU legislation. The study includes the legislative parameters, relative intermediate precision standard deviation (SRw,rel), trueness, sensitivity, linear range and ion ratio tolerance...
November 22, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27888289/epigenetic-synergism-between-interleukin-4-and-aryl-hydrocarbon-receptor-in-human-macrophages
#12
Wei-Ting Liao, Jian-He Lu, Wei-Ting Wang, Chih-Hsing Hung, Chau-Chyun Sheu, Shau-Ku Huang
: The aryl hydrocarbon receptor (AhR)-ligand axis is involved in immune regulation, but its molecular basis remains to be fully elucidated. Chemokine (C-C motif) ligand 1 (CCL1) is an important chemoattractant, but how CCL1 is regulated remains to be defined. The role of AhR in regulating CCL1 expression in two major subsets of macrophage was investigated. We used a human THP-1 cell line, monocytes, and mouse peritoneal macrophages to generate M(IFN-γ/LPS) and M(IL-4) subsets, and the AhR's ligand effect was determined by the use of a combination of chromatin immunoprecipitation, PCR, and ELISA...
November 25, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27886538/study-of-the-presence-of-pcdds-pcdfs-on-zero-valent-iron-nanoparticles
#13
Blanca Calderon, Lisa Lundin, Ignacio Aracil, Andres Fullana
Studies show that nanoscale zero-valent iron (nZVI) particles enhance the formation of chlorinated compounds such as polychlorinated dioxins and furans (PCDD/Fs) during thermal processes. However, it is unclear whether nZVI acts as a catalyst for the formation of these compounds or contains impurities, such as PCDD/Fs, within its structure. We analyzed the presence of PCDD/Fs in nZVI particles synthesized through various production methods to elucidate this uncertainty. None of the 2,3,7,8-substituted congeners were found in the commercially-produced nZVI, but they were present in the laboratory-synthesized nZVI produced through the borohydride method, particularly in particles synthesized from iron (III) chloride rather than from iron sulfate...
November 22, 2016: Chemosphere
https://www.readbyqxmd.com/read/27883971/2-3-7-8-tetrachlorodibenzo-p-dioxin-and-the-viral-infection
#14
REVIEW
Filomena Fiorito, Rita Santamaria, Carlo Irace, Luisa De Martino, Giuseppe Iovane
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious agents. In particular, several studies have provided evidence that TCDD decreases resistance to numerous viruses. Indeed, in vivo and in vitro investigations showed that the presence of TCDD is able to interfere with the replication of both human and animal viruses, such as influenza A viruses, coxsackie virus B3, immunodeficiency virus type-1 (HIV-1), cytomegalovirus (CMV), herpes simplex II, and bovine herpesvirus 1...
November 21, 2016: Environmental Research
https://www.readbyqxmd.com/read/27876543/in-utero-and-childhood-ddt-dde-pbde-and-pcbs-exposure-and-sex-hormones-in-adolescent-boys-the-chamacos-study
#15
Brenda Eskenazi, Stephen A Rauch, Rachel Tenerelli, Karen Huen, Nina T Holland, Robert H Lustig, Katherine Kogut, Asa Bradman, Andreas Sjödin, Kim G Harley
Dichlorodiphenyltrichloroethane (DDT), polybrominated diphenyl ether (PBDE) flame retardants, and polychlorinated biphenyls (PCBs) are believed to be endocrine-disrupting chemicals (EDCs) in humans and animals. The purpose of this study is to examine the relationship of in utero and childhood exposure to these purported EDCs and reproductive hormones in adolescent boys who participated in CHAMACOS, an ongoing birth cohort in California's Salinas Valley. We measured o,p'- and p,p'-DDT, p,p'-DDE, PBDEs and PCBs in serum collected from mothers during pregnancy or at delivery and from their sons at 9 years...
November 14, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27869691/bacterial-biotransformation-of-pentachlorophenol-and-micropollutants-formed-during-its-production-process
#16
REVIEW
Eglantina Lopez-Echartea, Tomas Macek, Katerina Demnerova, Ondrej Uhlik
Pentachlorophenol (PCP) is a toxic and persistent wood and cellulose preservative extensively used in the past decades. The production process of PCP generates polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) as micropollutants. PCDD/Fs are also known to be very persistent and dangerous for human health and ecosystem functioning. Several physico-chemical and biological technologies have been used to remove PCP and PCDD/Fs from the environment. Bacterial degradation appears to be a cost-effective way of removing these contaminants from soil while causing little impact on the environment...
November 17, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27866764/thermodynamic-features-of-dioxins-adsorption
#17
Marina Prisciandaro, Vincenzo Piemonte, Giuseppe Mazziotti di Celso, Silvia Ronconi, Mauro Capocelli
In this paper, the six more poisonous species among all congeners of dioxin group are taken into account, and the P-T diagram for each of them is developed. Starting from the knowledge of vapour tensions and thermodynamic parameters, the theoretical adsorption isotherms are calculated according to the Langmuir's model. In particular, the Langmuir isotherm parameters (K and wmax) have been validated through the estimation of the adsorption heat (ΔHads), which varies in the range 20-24kJ/mol, in agreement with literature values...
November 14, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27866539/-the-relationships-of-polychlorinated-dibenzo-p-dioxins-and-dibenzofurans-pcdd-fs-inhalational-dose-and-oxidative-damage-in-foundry-workers
#18
J T He, S K Zhang, M Zhao, Z Zhang, T M Shi, W H Chen
Objective: To investigate the potential dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage to DNA and lipid in foundry workers. Methods: The participants were divided into three groups, including exposure group, administrator group and control group. The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in air environment were determined by isotope dilution high resolution capillary column gas chromatography/high resolution mass spectrometry (HRGC-HRMS)...
September 20, 2016: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/27865896/reduced-cytotoxicity-in-pcb-exposed-chinese-hamster-ovary-cho-cells-pretreated-with-vitamin-e
#19
Teuta Murati, Branimir Šimić, Jelka Pleadin, Maja Vukmirović, Marina Miletić, Ksenija Durgo, Jasna Kniewald, Ivana Kmetič
The aim of this study was to evaluate protective effects of vitamin E (50 -150 μM) in ovary cells upon cytotoxic effects induced by two structurally distinct PCB congeners - planar "dioxin-like" PCB 77 and non-planar di-ortho-substituted PCB 153 with an emphasis on identifying differences in the mechanism of vitamin E action depending on the structure of congeners. Application of three bioassays confirmed that PCBs decrease ovarian cell proliferation with slightly profound effects of PCB 77. PCB - induced ROS production and lipid peroxidation were significant for both congeners with also more noticeable effect for PCB 77...
November 16, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27865101/diagnostic-guide-enabling-distinction-between-taphonomic-stains-and-enamel-hypomineralisation-in-an-archaeological-context
#20
Elsa Garot, Christine Couture-Veschambre, David Manton, Vincent Rodriguez, Yannick Lefrais, Patrick Rouas
OBJECTIVE: Molar Incisor Hypomineralisation (MIH) is a structural anomaly that affects the quality of tooth enamel and has important consequences for oral health. The developmentally hypomineralised enamel has normal thickness and can range in colour from white to yellow or brown with or without surface breakdown. The possibility of finding MIH in 'ancient populations' could downplay several current aetiological hypotheses (e.g., dioxin derivatives, bisphenols, antibiotics) without excluding the possible multifactorial aspect of the anomaly...
November 10, 2016: Archives of Oral Biology
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