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https://www.readbyqxmd.com/read/28343715/occurrence-profiles-and-toxic-equivalents-of-chlorinated-and-brominated-polycyclic-aromatic-hydrocarbons-in-e-waste-open-burning-soils
#1
Chiya Nishimura, Yuichi Horii, Shuhei Tanaka, Kwadwo Ansong Asante, Florencio Ballesteros, Pham Hung Viet, Takaaki Itai, Hidetaka Takigami, Shinsuke Tanabe, Takashi Fujimori
We conducted this study to assess the occurrence, profiles, and toxicity of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) and brominated polycyclic aromatic hydrocarbons (Br-PAHs) in e-waste open burning soils (EOBS). In this study, concentrations of 15 PAHs, 26 Cl-PAHs and 14 Br-PAHs were analyzed in EOBS samples. We found that e-waste open burning is an important emission source of Cl-PAHs and Br-PAHs as well as PAHs. Concentrations of total Cl-PAHs and Br-PAHs in e-waste open burning soil samples ranged from 21 to 2800 ng/g and from 5...
March 23, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28341125/corrigendum-to-reduction-of-dioxin-like-toxicity-in-effluents-by-additional-wastewater-treatment-and-related-effects-in-fish-ecotoxicol-environ-saf-132-2016-47-58
#2
D Maier, M Beníšek, L Bláha, F Dondero, J P Giesy, H-R Köhler, D Richter, M Scheurer, R Triebskorn
No abstract text is available yet for this article.
February 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28340459/transcriptional-profiling-of-porcine-granulosa-cells-exposed-to-2-3-7-8-tetrachlorodibenzo-p-dioxin
#3
Agnieszka Sadowska, Anna Nynca, Monika Ruszkowska, Lukasz Paukszto, Kamil Myszczynski, Karina Orlowska, Sylwia Swigonska, Tomasz Molcan, Jan P Jastrzebski, Renata E Ciereszko
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment. An exposure of living organisms to TCDD may result in numerous disorders, including reproductive pathologies. The aim of the current study was to examine the effects of TCDD on the transcriptome of porcine granulosa cell line AVG-16. By employing next-generation sequencing (NGS) we aimed to identify genes potentially involved in the mechanism of TCDD action and toxicity in porcine granulosa cells...
March 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28336320/preliminary-research-on-dna-methylation-changes-during-murine-palatogenesis-induced-by-tcdd
#4
Chen Wang, Xin-Gang Yuan, Cui-Ping Liu, Sha-Na Zhai, Ding-Wen Zhang, Yue-Xian Fu
2,3,7,8-Tetrachlrodibenzo-p-dioxin (TCDD) has been shown to induce cleft palate through growth factor and receptor expression changes during palatogenesis. DNA methylation is an important epigenetic modification that can regulate gene expressions and may be involved in TCDD-induced cleft palate. In this study, we investigated the effects of TCDD on the global and CpG DNA methylation status and the expression levels of DNA methyltransferases (Dnmts) in palate tissue of fetal mice. Pregnant C57BL/6J mice were administered with corn oil or TCDD 28 μg/kg at gestation day 10...
February 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28333458/declining-trends-of-polychlorinated-naphthalenes-in-seabird-eggs-from-the-canadian-arctic-1975-2014
#5
Birgit M Braune, Derek C G Muir
There are relatively few studies of polychlorinated naphthalenes (PCNs) for biota in polar regions and even fewer reports of temporal trends. We determined concentrations of PCNs in eggs of thick-billed murres (Uria lomvia) collected from the Canadian high Arctic between 1975 and 2014 and calculated their associated toxic equivalents (TEQs). Concentrations of Σ67PCN decreased significantly in the murre eggs between 1975 and 2014 at an average annual rate of -14.9 pg g(-1) wet weight. Although the penta- and tetra-CNs (predominantly CN-52/60 and CN-42) dominated the PCN profile, the hexa-CNs (mainly CN-66/67) accounted for the majority of the Σ67TEQ-PCN, concentrations of which also decreased significantly between 1975 to 2014...
March 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28316813/crystal-structure-of-poly-aqua-%C3%AE-2-3-di-hydro-thieno-3-4-b-1-4-dioxine-5-7-di-carboxyl-ato-%C3%AE%C2%BA-2-o-5-o-7-%C3%AE-di-pyridin-4-yl-sulfane-%C3%AE%C2%BA-2-n-n-zinc-0-26-hydrate
#6
Wen-Liang Wu, Bing Hu
The crystal structure of the title polymer, {[Zn(C8H4O6S)(C10H8N2S)(H2O)]·0.26H2O} n , is characterized by a layered arrangement parallel to the ab plane. The zinc cation is five-coordinated in a slightly distorted trigonal-bipyramidal coordination environment defined by two pyridine ligands, two carboxyl-ate groups of two thio-phene di-carboxyl-ate ligands, and by one water mol-ecule. The ethyl-ene bridge in the dioxine ligand is disordered over two sets of sites [occupancy ratio 0.624 (9):0.376 (9)]...
March 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28302560/2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd-induces-hepatic-stellate-cell-hsc-activation-and-liver-fibrosis-in-c57bl6-mouse-via-activating-akt-and-nf-%C3%AE%C2%BAb-signaling-pathways
#7
Ming Han, Xipeng Liu, Suyi Liu, Guanglei Su, Xikang Fan, Jie Chen, Qianting Yuan, Guangfei Xu
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant that could induce serious toxic effects in both humans and rodents. Some studies suggested that TCDD exposure may facilitate the activation of hepatic stellate cells (HSCs) and liver injury. However, the underlying molecular mechanism by which environmental pollutants promote liver injury remains poorly understood. In the present study, we established an animal model of TCDD exposure by intraperitoneal injection of TCDD in male C57BL/6J mice...
March 13, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28302335/theoretical-study-on-the-formation-mechanism-of-pre-intermediates-for-pxdd-fs-from-2-bromophenol-and-2-chlorophenol-precursors-via-radical-molecule-reactions
#8
Wenxiao Pan, Jianjie Fu, Aiqian Zhang
This study investigates reaction pathways for the formation of pre-PXDD/F intermediates via a radical/molecule mechanism. Thermodynamic and kinetic parameters for the combination reactions of 2-bromophenol (2-BP) and 2-chlorophenol (2-CP) precursors with key radical species including the phenoxy radicals, the phenyl radicals and the phenoxyl diradicals were calculated in detail. The couplings of phenoxy radicals with 2-B(C)P tend to produce pre-PXDD intermediates of halogenated o-phenoxyphenol. The combinations of phenyl and phenoxyl diradicals with 2-B(C)P produce two types of structures, i...
March 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28300844/il-27-triggers-il-10-production-in-th17-cells-via-a-c-maf-ror%C3%AE-t-blimp-1-signal-to-promote-the-progression-of-endometriosis
#9
Kai-Kai Chang, Li-Bing Liu, Li-Ping Jin, Bing Zhang, Jie Mei, Hui Li, Chun-Yan Wei, Wen-Jie Zhou, Xiao-Yong Zhu, Jun Shao, Da-Jin Li, Ming-Qing Li
Endometriosis is an estrogen-dependent inflammatory disease. The anti-inflammatory cytokine IL-10 is also increased in endometriosis. IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. However, the mechanism of inducing IL-10-producing Th17 cells is still largely unknown. The present study investigated the differentiation mechanism and role of IL-10-producing Th17 cells in endometriosis. Here, we report that IL-10(+)Th17 cells are significantly increased in the peritoneal fluid of women with endometriosis, along with an elevation of IL-27, IL-6 and TGF-β...
March 16, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28299486/the-influence-of-%C3%AE-tocopherol-on-serum-biochemical-markers-during-experimentally-induced-pleuritis-in-rats-exposed-to-dioxin
#10
Ireneusz Całkosiński, Kinga Gostomska-Pampuch, Jacek Majda, Anna Leśków, Maciej Janeczek, Oleg P Melnyk, Andrzej Gamian
Toxicity of dioxins is wide ranging. Amongst the organs, the liver is the most susceptible to damage by dioxins. Damage caused to liver cells results in promoting inflammatory processes. The aim of this work was to evaluate whether high doses of tocopherol will change the inflammatory response, monitored by biochemical indicators, by improving liver function in rats exposed to tetrachlorodibenzo-p-dioxin (TCDD). The study was conducted on a population of female Buffalo rats. The animals were divided into the following groups: Control Group A-representing physiological norms for the studied diagnostic indicators; Control Group B-subjects were administered a 1% ceragenin solution to induce pleuritis; Study Group 1-where rats were administered α-tocopherol acetate for 3 weeks, after which pleuritis was induced; Study Group 2-rats were administered a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), while 3 weeks later, pleuritis was induced; and Study Group 3-rats were administered a single dose of TCDD and next, were administered α-tocopherol acetate for 3 weeks, followed by pleuritis induction...
March 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28286111/spermatogenesis-disruption-by-dioxins-epigenetic-reprograming-and-windows-of-susceptibility
#11
REVIEW
J Richard Pilsner, Mikhail Parker, Oleg Sergeyev, Alexander Suvorov
Dioxins are a group of highly persistent chemicals that are generated as by-products of industrial and natural processes. Reduction in sperm counts are among the most sensitive endpoints of dioxin toxicity. The exact mechanism by which dioxins reduce sperm counts is not known. Recent data implicate the role of epididymal factors rather than disruption of spermatogenesis. Studies reviewed here demonstrate that dioxins induce the transfer of environmental conditions to the next generation via male germline following exposures during the window of epigenetic reprogramming of primordial germ cells...
March 7, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28284726/endocrine-disrupting-compounds-modulates-adiponectin-secretion-expression-of-its-receptors-and-action-on-steroidogenesis-in-ovarian-follicle
#12
Agnieszka Rak, Karolina Zajda, Ewa Łucja Gregoraszczuk
We determined the effect of dioxin-like polychlorinated naphtalenes (PCN) (Halowax 1051) (100pg/ml), benzo(a)pyrene [B(a)P] (2.5ng/ml), hexachlorobenzene (HCBz) (0.2ng/ml) and non-dioxin like polybrominated diphenyl ether (BDE-47) (25ng/ml) and bisphenol A (BPA) (20ng/ml) on ovarian adiponectin secretion (ELISA) and its receptors expression (Western blot). Ovarian cells co-culture was used to examine action of endocrine disruptors (EDCs) on adiponectin (10μg/ml) stimulated steroidogenesis. B(a)P, HCBz, testosterone (T) decreased adiponectin secretion and receptors expression, BPA, BDE-47, estradiol (E2) had the opposite effect, while PCN had inhibitory effect only on adiponectin secretion...
March 8, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28284547/levels-of-pcdd-fs-and-dioxin-like-pcbs-in-seafood-from-sydney-harbour-australia
#13
Therese M Manning, Anthony C Roach, Katelyn J Edge, Doug J Ferrell
Sydney Harbour, Australia is contaminated with polychlorinated dibenzo-p-dioxins and furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) due to a historical Union Carbide chemical manufacturing facility. We measured levels of PCDD/Fs and dl-PCBs in over 400 seafood samples (covering 20 species) collected throughout Sydney Harbour. Concentrations ranged from 0.1 to 193 pg total TEQ (WHO05)/g wet weight. These concentrations were above those considered safe for human consumption in many cases...
March 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28282589/lower-concentrations-of-receptor-for-advanced-glycation-end-products-and-epiregulin-in-amniotic-fluid-correlate-to-chemically-induced-cleft-palate-in-mice
#14
Xinhuan Wang, Jingjing Zhu, Yanjun Fang, Zhuan Bian, Liuyan Meng
This study investigated the correlation between differentially expressed proteins in amniotic fluid (AF) and cleft palate induced by all-trans retinoic acid (atRA), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. Seven proteins were differentially expressed at embryonic day (E) 16.5 in atRA and control groups as revealed by label-based mouse antibody array. Enzyme-linked immunosorbent assay was further used to detect the expression levels of these proteins in AF from E13.5 to E16.5 in atRA, TCDD, and control groups...
February 28, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28275726/enhanced-pedot-adhesion-on-solid-substrates-with-electrografted-p-edot-nh2
#15
Liangqi Ouyang, Bin Wei, Chin-Chen Kuo, Sheevangi Pathak, Brendan Farrell, David C Martin
Conjugated polymers, such as poly(3,4-ethylene dioxythiophene) (PEDOT), have emerged as promising materials for interfacing biomedical devices with tissue because of their relatively soft mechanical properties, versatile organic chemistry, and inherent ability to conduct both ions and electrons. However, their limited adhesion to substrates is a concern for in vivo applications. We report an electrografting method to create covalently bonded PEDOT on solid substrates. An amine-functionalized EDOT derivative (2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methanamine (EDOT-NH2), was synthesized and then electrografted onto conducting substrates including platinum, iridium, and indium tin oxide...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28270159/a-path-analysis-of-multiple-neurotoxic-chemicals-and-cognitive-functioning-in-older-us-adults-nhanes-1999-2002
#16
Jennifer Przybyla, E Andres Houseman, Ellen Smit, Molly L Kile
BACKGROUND: Polychlorinated biphenyls (PCBs) and metals (lead and cadmium) are neurotoxic and affect neurobehavioral performance. Yet little is known about the association between exposure to multiple neurotoxic compounds and cognitive functioning in older adults. METHODS: Using data from two consecutive cycles of the National Health and Nutrition and Examination Survey (1999-2002), path analysis was used to simultaneously evaluate the association between whole blood concentrations of 14 neurotoxic compounds and cognitive functioning measured by the Digit Symbol Coding Test of the Weschler Adult Intelligence Scale, 3(rd) Edition in participants 60-84 years of age (N = 498)...
March 7, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28268020/in-vivo-erod-assays-with-the-zebrafish-danio-rerio-as-rapid-screening-tools-for-the-detection-of-dioxin-like-activity
#17
Britta Kais, Sabrina Schiwy, Henner Hollert, Steffen H Keiter, Thomas Braunbeck
The present study compares two alternative in vivo approaches for the measurement of ethoxyresorufin-O-deethylase (EROD) activity in zebrafish (Danio rerio) following exposure to acetonic model sediment extracts: (1) the live-imaging EROD assay for the direct detection of EROD induction in individual livers via epifluorescence, and (2) the fish embryo EROD assay in subcellular fractions derived from entire zebrafish embryos after in vivo exposure. For toxicity assessment, each sediment extract was tested with the standard fish embryo test (FET)...
March 4, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28267985/in-vitro-modulatory-effects-of-functionalized-pyrimidines-and-piperidine-derivatives-on-aryl-hydrocarbon-receptor-ahr-and-glucocorticoid-receptor-gr-activities
#18
Muhammad Yar, Lubna Shahzadi, Ariba Farooq, Saima Jalil Imran, José P Cerón-Carrasco, Helena den-Haan, Sanjay Kumar, Jorge Peña-García, Horacio Pérez-Sánchez, Aneta Grycova, Zdenek Dvorak, Radim Vrzal
The development of biologically active molecules based on molecular recognition is an attractive and challenging task in medicinal chemistry and the molecules that can activate/deactivate certain receptors are of great medical interest. In this contribution, selected pyrimidine/piperidine derivatives were synthesized and tested for the ability to activate/deactivate Aryl hydrocarbon receptor (AhR) and Glucocorticoid receptor (GR). Tested compounds are shown to activate the receptors but to much lesser extent than positive controls, dioxin and dexamethasone for Ahr and GR, respectively...
February 21, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28263562/evaluation-of-externality-costs-in-life-cycle-optimization-of-municipal-solid-waste-management-systems
#19
Veronica Martinez-Sanchez, James W Levis, Anders Damgaard, Joseph F DeCarolis, Morton A Barlaz, Thomas F Astrup
The development of sustainable solid waste management (SWM) systems requires consideration of both economic and environmental impacts. Societal life-cycle costing (S-LCC) provides a quantitative framework to estimate both economic and environmental impacts, by including "budget costs" and "externality costs". Budget costs include market goods and services (economic impact), whereas externality costs include effects outside the economic system (e.g., environmental impact). This study demonstrates the applicability of S-LCC to SWM life-cycle optimization through a case study based on an average suburban U...
March 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28261155/environmental-factors-impacting-bone-relevant-chemokines
#20
Justin T Smith, Andrew D Schneider, Karina M Katchko, Chawon Yun, Erin L Hsu
Chemokines play an important role in normal bone physiology and the pathophysiology of many bone diseases. The recent increased focus on the individual roles of this class of proteins in the context of bone has shown that members of the two major chemokine subfamilies-CC and CXC-support or promote the formation of new bone and the remodeling of existing bone in response to a myriad of stimuli. These chemotactic molecules are crucial in orchestrating appropriate cellular homing, osteoblastogenesis, and osteoclastogenesis during normal bone repair...
2017: Frontiers in Endocrinology
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