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https://www.readbyqxmd.com/read/29778078/an-effective-and-low-cost-carbon-based-clean-up-method-for-pcdd-fs-and-pcbs-analysis-in-food
#1
Kleopatra Kedikoglou, Danae Costopoulou, Irene Vassiliadou, Evangelos Bakeas, Leondios Leondiadis
Sample preparation is of critical importance in dioxin analysis of food and feed samples. It is a complex procedure that includes lipid extraction followed by the application of chromatographic separation techniques, aiming in removing undesirable interferences from the matrix. The separation of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) from polychlorinated biphenyls (PCBs) is achieved by carbon-based materials which should have high fat capacity in order to be suitable for lipid-containing matrices...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778059/tracking-pollutants-in-dietary-fish-oil-from-ocean-to-table
#2
Sheng-Xiang Sun, Xue-Ming Hua, Yun-Yun Deng, Yun-Ni Zhang, Jia-Min Li, Zhao Wu, Samwel Mchele Limbu, Da-Sheng Lu, Hao-Wen Yin, Guo-Quan Wang, Rune Waagbø, Frøyland Livar, Mei-Ling Zhang, Zhen-Yu Du
Dietary fish oil used in aquafeed transfers marine pollutants to farmed fish. However, the entire transfer route of marine pollutants in dietary fish oil from ocean to table fish has not been tracked quantitatively. To track the entire transfer route of marine pollutants from wild fish to farmed fish through dietary fish oil and evaluate the related human health risks, we obtained crude and refined fish oils originating from the same batch of wild ocean anchovy and prepared fish oil-containing purified aquafeeds to feed omnivorous lean Nile tilapia and carnivorous fatty yellow catfish for eight weeks...
May 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29775880/photocatalytic-reductive-dechlorination-of-2-chlorodibenzo-p-dioxin-by-pd-modified-g-c-3-n-4-photocatalysts-under-uv-vis-irradiation-efficacy-kinetics-and-mechanism
#3
Jiafeng Ding, Gaoyuan Long, Yang Luo, Runze Sun, Mengxia Chen, Yajun Li, Yanfang Zhou, Xinhua Xu, Weirong Zhao
Polychlorinated dibenzo-p-dioxins (PCDDs), as a group of notorious anthropogenic environmental toxicants, are arguably ubiquitous in nature. In this study, we investigated the photocatalytic reductive dechlorination of 2-chlorodibenzo-p-dioxin (2-CDD) over Pd/g-C3 N4 catalysts under UV-vis irradiation. The g-C3 N4 and a series of Pd/g-C3 N4 catalysts were prepared by thermal polymerization and mechanical mixing-illumination method and characterized by XRD, TEM, BET, SEM and UV-vis DRS analyses. Among all the samples, the Pd/g-C3 N4 (5 wt%) yielded the optimal dechlorination activity with a total 2-CDD conversion of 54% within 4 h, and 76% of those converted 2-CDD were evolved to dibenzo-p-dioxin (DD)...
May 9, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29763869/exposure-of-dioxin-like-chemicals-in-participants-of-the-anniston-community-health-survey-follow-up
#4
Eric Yang, Marian Pavuk, Andreas Sjödin, Michael Lewin, Richard Jones, Jim Olson, Linda Birnbaum
The 2014 follow-up of the Anniston Community Health Survey (ACHS II) consisted of 338 surviving participants from the 2005-2007 baseline study (ACHS) who had previous polychlorinated biphenyl (PCB) measurements, were not pregnant, and were not institutionalized. Questionnaires and blood samples provided the demographic, personal history, and chemical concentration data of the Anniston residents. Approximately 51% of participants were African American, 72% were female, and the mean age was 63 years old. The objectives of this study were to provide an exposure assessment of dioxin-like chemicals in the ACHS II participants and compare the measurements with the general United States (U...
May 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29763690/the-citrus-flavonone-hesperetin-attenuates-the-nuclear-translocation-of-aryl-hydrocarbon-receptor
#5
Yan Qin Tan, Leo Clement Chiu-Leung, Shu-Mei Lin, Lai K Leung
The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Hesperetin is a flavonone found abundantly in citrus fruits and has been shown to be a biologically active agent. In the present study, the effect of hesperetin on the nuclear translocation of AhR and the downstream gene expression was investigated in MCF-7 cells. Confocal microscopy indicated that 7, 12-dimethylbenz[α]anthracene (DMBA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) -induced nuclear translocation of AhR was deterred by hesperetin treatment...
May 12, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29758879/inhibition-of-element-sulfur-and-calcium-oxide-on-the-formation-of-pcdd-fs-during-co-combustion-experiment-of-municipal-solid-waste
#6
Hongting Ma, Na Du, Xueyin Lin, Chaofan Liu, Jingyu Zhang, Zhuangzhuang Miao
In order to investigate the effect of element sulfur (S) and calcium oxide (CaO) on the formation of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) during municipal solid waste (MSW) combustion process, MSW was incinerated with S or CaO in a laboratory-scale incinerator and heated in the flow of N2 -O2 gas mixture at 800°C. It can be concluded that 25% of oxygen concentration is the best condition for the following inhibitors experiments through a series of oxygen variation experiments...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29753751/the-aryl-hydrocarbon-receptor-is-indispensable-for-dioxin-induced-defects-in-sexually-dimorphic-behaviors-due-to-the-reduction-in-fetal-steroidogenesis-of-the-pituitary-gonadal-axis-in-rats
#7
Yukiko Hattori, Tomoki Takeda, Arisa Nakamura, Kyoko Nishida, Yuko Shioji, Haruki Fukumitsu, Hideyuki Yamada, Yuji Ishii
Many forms of the toxic effects produced by dioxins and related chemicals take place following activation of the aryl hydrocarbon receptor (AHR). Our previous studies have demonstrated that treating pregnant rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic dioxin, attenuates the pituitary expression of gonadotropins to reduce testicular steroidogenesis during the fetal stage, resulting in the impairment of sexually-dimorphic behaviors after the offspring reach maturity. To investigate the contribution of AHR to these disorders, we examined the effects of TCDD on AHR-knockout (AHR-KO) Wistar rats...
May 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29753148/sex-related-differences-in-the-associations-between-maternal-dioxin-like-compounds-and-reproductive-and-steroid-hormones-in-cord-blood-the-hokkaido-study
#8
Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi
BACKGROUND: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. OBJECTIVE: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. METHODS: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29752697/biofortification-of-safflower-an-oil-seed-crop-engineered-for-ala-targeting-better-sustainability-and-plant-based-omega-3-fatty-acids
#9
Arti Rani, Asha Panwar, Manjary Sathe, Karunakara Alageri Chandrashekhara, Anil Kush
Alpha-linolenic acid (ALA) deficiency and a skewed n6:n3 fatty acid ratio in the diet is a major explanation for the prevalence of cardiovascular diseases and inflammatory/autoimmune diseases. There is mounting evidence of the health benefits associated with omega-3 long chain polyunsaturated fatty acids (LC PUFA's). Although present in abundance in fish, a number of factors limit our consumption of fish based omega-3 PUFA's. To name a few, overexploitation of wild fish stocks has reduced their sustainability due to increased demand of aquaculture for fish oil and meal; the pollution of marine food webs has raised concerns over the ingestion of toxic substances such as heavy metals and dioxins; vegetarians do not consider fish-based sources for supplemental nutrition...
May 11, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29752597/the-higher-prevalence-of-developmental-defects-of-enamel-in-the-dioxin-affected-region-than-non-dioxin-affected-region-result-from-a-cross-sectional-study-in-vietnam
#10
Vo Truong Nhu Ngoc, Le Thi Huong, Bui Van Nhon, Ngo Thi Minh Tan, Pham Van Thuc, Vo Thi Thu Hien, Truong Manh Dung, Ngo Van Toan, Le Quynh Anh, Le Hoang Son, Thien Chu-Dinh, Dinh-Toi Chu
Developmental defects of enamel (DDE) are induced and regulated by several factors including genetics and the environment. There is evidence showing that dioxin in polluted areas has a strong effect on the health and development of teeth. However, there has been no study on DDE in the dioxin-affected regions in Vietnam. To identify the effect of dioxin on the prevalence of DDE in studied areas in Vietnam, a cross-sectional study was conducted in 2200 adults in the A Luoi district in the Thua Thien Hue province (the dioxin-affected region) and in the Kim Bang district in the Ha Nam province (dioxin-unaffected region) in 2015...
May 11, 2018: Odontology
https://www.readbyqxmd.com/read/29752288/comparison-of-hepatic-nrf2-and-ahr-binding-in-2-3-7-8-tetrachlorodibenzo-p-dioxin-tcdd-treated-mice-demonstrates-nrf2-independent-pkm2-induction
#11
Rance Nault, Claire M Doskey, Kelly A Fader, Cheryl E Rockwell, Timothy R Zacharewski
2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) induces hepatic oxidative stress following activation of the aryl hydrocarbon receptor (AhR). Our recent studies showed TCDD induced pyruvate kinase muscle isoform 2 ( Pkm2 ) as a novel antioxidant response in normal differentiated hepatocytes. To investigate cooperative regulation between nuclear factor, erythroid derived 2, like 2 ( Nrf2 ) and the AhR in the induction of Pkm2 , hepatic ChIP-seq analyses were integrated with RNA-seq time course data from mice treated with TCDD for 2 - 168h...
May 11, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29751587/pcbs-and-pcdd-fs-in-bluefin-tuna-occurrence-and-dietary-intake
#12
Grazia Barone, Arianna Storelli, Rita Garofalo, Rosanna Mallamaci, Nicoletta C Quaglia, Maria Maddalena Storelli
Polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-furans (PCDD/Fs) were measured in Mediterranean bluefin tuna ( Thunnus thynnus ) to verify the compliance with the EU regulations for food commercialization. The estimated intakes were also evaluated. The analyses were performed by gas chromatography-ion trap tandem mass spectrometry (GC-MS-MS). The PCBs were dominant (1132.0 ng g−1 l.w.), followed by PCDFs (23.2 pg g−1 l.w.) and PCDDs (8.5 pg g−1 l.w.). The pollutant levels (dl-PCBs: 0...
May 3, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29751436/prenatal-dioxin-exposure-estimated-from-dioxins-in-breast-milk-and-sex-hormone-levels-in-umbilical-cord-blood-in-vietnamese-newborn-infants
#13
Hitomi Boda, Tran Ngoc Nghi, Muneko Nishijo, Pham Ngoc Thao, Pham The Tai, Hoang Van Luong, Tran Hai Anh, Yuko Morikawa, Yoshikazu Nishino, Hisao Nishijo
Dioxin concentrations remain elevated in the environment and humans residing near the former US Air Force base in Bien Hoa city, South Vietnam. We recruited 210 mother-infant pairs for whom breast milk dioxin levels were reported in our previous study. Cord blood samples were collected from 162 mother-infant pairs. We selected 16 cord blood samples with a volume over 20mL and fat content of ≥0.03g. Toxic equivalent levels of polychlorinated dibenzodioxins and polychlorinated dibenzofurans (TEQ-PCDD/Fs) and concentrations of 17 congeners, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD), in cord blood were measured and compared with levels in breast milk (Study 1)...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751429/association-of-prenatal-exposure-to-pcdd-fs-and-pcbs-with-maternal-and-infant-thyroid-hormones-the-hokkaido-study-on-environment-and-children-s-health
#14
Toshiaki Baba, Sachiko Ito, Motoyuki Yuasa, Eiji Yoshioka, Chihiro Miyashita, Atsuko Araki, Seiko Sasaki, Sumitaka Kobayashi, Jumboku Kajiwara, Tsuguhide Hori, Shizue Kato, Reiko Kishi
Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and biphenyls (PCBs) are persistent organic pollutants that are universally detected. Some congeners of PCDDs, PCDFs or PCBs have dioxin-like toxicity, whereas non-dioxin-like PCBs are considered to have different toxicity. Reports of the relationships between prenatal exposure to PCDDs, PCDFs or PCBs and thyroid homeostasis in pregnant women and infants have been inconsistent. The aim of this study was to investigate the effect of maternal serum PCDD/F or PCB levels on maternal and neonatal thyroid hormone (TH) levels in a prospective cohort...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751420/birth-cohorts-in-asia-the-importance-advantages-and-disadvantages-of-different-sized-cohorts
#15
Reiko Kishi, Atsuko Araki, Machiko Minatoya, Sachiko Itoh, Houman Goudarzi, Chihiro Miyashita
Asia contains half of the world's children, and the countries of Asia are the most rapidly industrializing nations on the globe. Environmental threats to the health of children in Asia are myriad. Several birth cohorts were started in Asia in early 2000, and currently more than 30 cohorts in 13 countries have been established for study. Cohorts can contain from approximately 100-200 to 20,000-30,000 participants. Furthermore, national cohorts targeting over 100,000 participants have been launched in Japan and Korea...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751400/2-3-7-8-tetrachlorodibenzo-p-dioxin-induces-alterations-in-myogenic-differentiation-of-c2c12-cells
#16
Heidi Q Xie, Yingjie Xia, Tuan Xu, Yangsheng Chen, Hualing Fu, Yunping Li, Yali Luo, Li Xu, Karl W K Tsim, Bin Zhao
Dioxin-induced toxicities that affect the development of the motor system have been proposed since many years. However, cellular evidence and the molecular basis for the effects are limited. In this study, a cultured mouse myoblast cell line, C2C12, was utilized to examine the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on myogenic differentiation and expression of acetylcholinesterase (AChE), a neuromuscular transmission-related gene. The results showed that TCDD exposure at 10-10  M repressed the myotube formation of C2C12 cells by disturbing the fusion process and suppressing the expression of myosin heavy chain, a myobute structural protein, and not by induction of cytotoxicity...
April 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29748732/site-specific-bioaccumulation-of-polychlorinated-dibenzo-p-dioxins-and-polychlorinated-dibenzofurans-pcdd-pcdfs-in-mothers-and-their-infants-living-in-vicinity-of-bien-hoa-airbase-southern-vietnam
#17
Nguyen Thi Minh Hue, Nguyen Van Thuong, Pham Thi Ngoc Mai, Nguyen Hung Minh
Bien Hoa airbase is located in Dong Nai Province (Southern Vietnam). Several sites within the airbase are highly contaminated by Agent Orange/Dioxin, and thus, they are also commonly named as an Agent Orange/Dioxin hotpot. In the present study, 36 maternal milk samples were collected from primiparas who have lived at least 5 years in four wards, Buu Long, Quang Vinh, Trung Dung and Tan Phong, which are closed to Bien Hoa airbase in order to investigate the level and distribution of Agent Orange/Dioxin exposure in different local communities...
May 10, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29743862/the-aryl-hydrocarbon-receptor-and-retinoid-receptors-cross-talk-at-the-cyp1a1-promoter-in-vitro
#18
Stefanie Hessel-Pras, Anke Ehlers, Albert Braeuning, Alfonso Lampen
The epithelium of the small intestine plays an important role in detoxification processes due to the presence of various xenobiotic-metabolizing enzymes from phase I and II, as well as transport proteins of the ATP-binding cassette superfamily. Exposure to xenobiotics induces the expression of these proteins in the small intestine, with multiple signaling pathways stimulated by exogenous compounds converging at individual gene promoters by mechanisms which have not been fully understood yet. In this context the promoter region of the CYP1A1 gene, encoding the phase I monooxygenase cytochrome P450 1A1, was analyzed by chromatin immunoprecipitation with regard to binding of xeno-sensing receptors following stimulation of Caco-2 cells with agonists of the aryl hydrocarbon receptor (AHR) and retinoid receptors...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29742706/impact-of-presumed-service-connected-diagnosis-on-the-department-of-veterans-affairs-healthcare-utilization-patterns-of-vietnam-theater-veterans-a-cross-sectional-study
#19
Dennis A Fried, Mangala Rajan, Chin-Lin Tseng, Drew Helmer
During the Vietnam War, the US military sprayed almost 20 million gallons of Agent Orange (AO), an herbicide contaminated with dioxin, over Vietnam. Approximately, 2.7 million US military personnel may have been exposed to AO during their deployment. Ordinarily, veterans who can demonstrate a nexus between a diagnosed condition and military service are eligible for Department of Veterans Affairs (VA) service-connected disability compensation. Vietnam Veterans have had difficulty, however, establishing a nexus between AO exposure and certain medical conditions that developed many years after the war...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29741588/paternal-developmental-toxicant-exposure-is-associated-with-epigenetic-modulation-of-sperm-and-placental-pgr-and-igf2-in-a-mouse-model
#20
Tianbing Ding, Shilpa Mokshagundam, Paolo F Rinaudo, Kevin G Osteen, Kaylon L Bruner-Tran
Preterm birth (PTB), parturition prior to 37 weeks gestation, is the leading cause of neonatal mortality. The causes of spontaneous PTB are poorly understood; however, recent studies suggest this condition may arise as a consequence of the parental fetal environment. Specifically, we previously demonstrated that developmental exposure of male mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with reduced sperm quantity/quality in adulthood and control female partners frequently delivered preterm...
May 7, 2018: Biology of Reproduction
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