Larissa Fabritz, Winnie Chua, Victor R Cardoso, Christoph Al-Taie, Katrin Borof, Anna Suling, Linda Krause, Shino Kany, Christina Magnussen, Karl Wegscheider, Guenter Breithardt, Harry J G M Crijns, A John Camm, George Gkoutos, Patrick T Ellinor, Andreas Goette, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Renate B Schnabel, Antonia Zapf, Paulus Kirchhof
BACKGROUND: Atrial fibrillation (AF) and concomitant cardiometabolic disease processes interact and combine to lead to adverse events such as stroke, heart failure, myocardial infarction, and cardiovascular death. Circulating biomolecules provide quantifiable proxies for cardiometabolic disease processes. Their role in defining subphenotypes of AF is not known. METHODS AND RESULTS: This prespecified analysis of the EAST-AFNET4 biomolecule study assigned patients to clusters using polytomous variable latent class analysis (poLCA) based on baseline concentrations of thirteen precisely-quantified biomolecules potentially reflecting ageing, cardiac fibrosis, metabolic dysfunction, oxidative stress, cardiac load, endothelial dysfunction, and inflammation...
April 13, 2024: Cardiovascular Research