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Endothelial dysfunction

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https://www.readbyqxmd.com/read/29679467/salidroside-protects-against-advanced-glycation-end-products-induced-vascular-endothelial-dysfunction
#1
Peng Zhang, Yuanmin Li, Rong Guo, Wangfu Zang
BACKGROUND Salidroside, the major active compound in Rhodiola, has been reported to provide beneficial effects on cardiovascular diseases, but its effects on diabetes-induced vascular endothelial dysfunction are less known. Here, we examined the protective effects of salidroside on endothelial function in diabetes and explored the potential underlying mechanism. MATERIAL AND METHODS First, we assessed the endothelium-dependent relaxation response to acetylcholine, with or without salidroside treatment, in aortas isolated from Sprague-Dawley rats...
April 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29679259/dna-methylation-a-potential-source-of-mitochondria-dna-base-mismatch-in-the-development-of-diabetic-retinopathy
#2
Manish Mishra, Renu A Kowluru
In the development of diabetic retinopathy, retinal mitochondria are dysfunctional, and mitochondrial DNA (mtDNA) is damaged with increased base mismatches and hypermethylated cytosines. DNA methylation is also a potential source of mutation, and in diabetes, the noncoding region, the displacement loop (D-loop), experiences more methylation and base mismatches than other regions of the mtDNA. Our aim was to investigate a possible crosstalk between mtDNA methylation and base mismatches in the development of diabetic retinopathy...
April 21, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29678841/the-effect-of-hyperbaric-oxygen-therapy-on-myocardial-perfusion-after-the-implantation-of-drug-eluting-stents
#3
Yuan Li, Yafeng Hao, Tao Wang, Lingge Wei, Wei Wang, Yi Liang, Xuan Guo
AIM: The study is to investigate hyperbaric oxygen therapy (HBOT) on myocardial perfusion of patients after the implantation of drug-eluting stents (DES) METHODS: From December 2013 to December 2015, a total of 115 patients with CAD who received DES implantation were included in this retrospective study. They were divided into HBOT group (n=55) and control group (n=60) according to different treatments retrospectively. Gated myocardial perfusion single photon emission computed tomography (SPECT) was conducted in all the patients...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29677687/endothelial-dysfunction-as-a-long-term-effect-of-late-onset-hypertensive-pregnancy-disorders-high-bmi-is-key
#4
L J Alma, C J M De Groot, R X De Menezes, W Hermes, P L Hordijk, I Kovačević
OBJECTIVE: Hypertensive disorders during pregnancy increase cardiovascular risk later in life by 2 to 9-fold. Endothelial activation is one of the underlying mechanisms of cardiovascular risk. Therefore, we decided to investigate endothelial activation in primiparous women, 2.5 years after a hypertensive pregnancy disorder. STUDY DESIGN: Plasma samples were taken from women 2.5 years after gestational hypertension (GH) or late onset preeclampsia (cases) and from women 2...
April 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29677629/effects-of-gastric-bypass-surgery-followed-by-supervised-physical-training-on-inflammation-and-endothelial-function-a-randomized-controlled-trial
#5
Charlotte Røn Stolberg, Lene Hymøller Mundbjerg, Peter Funch-Jensen, Bibi Gram, Else-Marie Bladbjerg, Claus Bogh Juhl
BACKGROUND AND AIMS: Obesity and physical inactivity are both associated with low-grade inflammation and endothelial dysfunction. Bariatric surgery improves markers of inflammation and endothelial function, but it is unknown if physical training after bariatric surgery can improve these markers even further. Therefore, we aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) followed by physical training on markers of low-grade inflammation and endothelial function. METHODS: Sixty patients approved for RYGB underwent examinations pre-surgery, 6, 12, and 24 months post-surgery...
April 6, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29677517/gpr68-senses-flow-and-is-essential-for-vascular-physiology
#6
Jie Xu, Jayanti Mathur, Emilie Vessières, Scott Hammack, Keiko Nonomura, Julie Favre, Linda Grimaud, Matt Petrus, Allain Francisco, Jingyuan Li, Van Lee, Fu-Li Xiang, James K Mainquist, Stuart M Cahalan, Anthony P Orth, John R Walker, Shang Ma, Viktor Lukacs, Laura Bordone, Michael Bandell, Bryan Laffitte, Yan Xu, Shu Chien, Daniel Henrion, Ardem Patapoutian
Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction and a precursor to a wide array of vascular diseases, such as hypertension and atherosclerosis. Yet the molecules responsible for sensing flow (shear stress) within endothelial cells remain largely unknown. We designed a 384-well screening system that applies shear stress on cultured cells...
April 19, 2018: Cell
https://www.readbyqxmd.com/read/29676873/-bradykinin-and-cardiovascular-protection-role-of-perindopril-an-inhibitor-of-angiotensin-conversion-enzyme
#7
P Lancellotti, A Ancion, V D'Orio, O Gach, P Maréchal, J M Krzesinski
The endothelium plays a vital role as part of the cardiovascular continuum. Risk factors such as hypertension and dyslipidemia unbalance angiotensin II - bradykinin homeostasis, leading to endothelial dysfunction and changes in vascular structure that promote atherosclerosis and thrombosis. When dealing with risk factors, treatment should focus on the prevention and restoration of endothelial function. Not all cardiovascular drugs are able to reverse vascular and structural endothelial dysfunction. Increasing levels of bradykinin is an effect of the use of angiotensin-converting enzyme inhibitors (ACE-Is), and also a fundamental part of their mode of action...
April 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29676814/potential-of-carnosine-a-histamine-precursor-in-rat-model-of-bilateral-common-carotid-artery-occlusion-induced-vascular-dementia
#8
Nidhi Tiwari, Pankaj Bhatia, Amit Kumar, Amteshwar S Jaggi, Nirmal Singh
The present study investigates the potential of Carnosine a histamine precursor, in rat model of bilateral common carotid artery occlusion (BCCAo) induced vascular dementia (VaD). Wistar rats were subjected to BCCAo procedure under anesthesia to induce VaD. The rats were subjected to Morris water-maze (MWM) test (6th day onwards post-surgery). MWM test was employed to assess learning and memory of the animals whereby ELT (escape latency time), TSTQ (time spent in target quadrant) and Path length (distance travelled) taken as important parameters...
April 20, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29676291/pancreatic-kininogenase-improves-erectile-function-in-streptozotocin-induced-type-2-diabetic-rats-with-erectile-dysfunction
#9
Guo-Tao Chen, Bai-Bing Yang, Jian-Huai Chen, Zheng Zhang, Lei-Lei Zhu, He-Song Jiang, Wen Yu, Yun Chen, Yu-Tian Dai
Erectile dysfunction (ED) associated with type 2 diabetes is a severe problem that requires effective treatment. Pancreatic kininogenase (PK) has the potential to improve the erectile function of ED patients. This study aims to investigate the effect of PK on erectile function in streptozotocin-induced type 2 diabetic ED rats. To achieve this goal, we divided male Sprague-Dawley rats into five groups. One group was not treated, and the other four groups were treated with saline, sildenafil, PK or sildenafil, and PK, respectively, for 4 weeks after the induction of type 2 diabetic ED...
April 20, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29675623/influence-of-autoimmunity-and-inflammation-on-endothelial-function-and-thrombosis-in-systemic-lupus-erythematosus-patients
#10
Kamil Bugała, Adam Mazurek, Krzysztof Gryga, Monika Komar, Grzegorz Kopeć, Jacek Musiał, Piotr Podolec, Carlo Perricone, Wojciech Płazak
The aim of this study is to assess the relationship between autoimmunity and endothelial activation/damage (ICAM-1 and vWF serum levels) and the degree of prothrombotic activity (thrombin-antithrombin complexes-TAT serum levels) in SLE. In 60 clinically stable SLE patients, levels of the following parameters were estimated in their serum: lupus anticoagulant (LA), anticardiolipin antibodies in both IgG and IgM classes (aCL-IgG and aCL-IgM, respectively), antiβ2GPI antibodies in both IgG and IgM classes (antiβ2GPI-IgG and antiβ2GPI-IgM, respectively), ICAM, von Willebrand factor (vWF), TAT, CRP, C3c, C4, and IL-6...
April 20, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29675553/a-potential-strategy-for-treating-atherosclerosis-improving-endothelial-function-via-amp-activated-protein-kinase
#11
REVIEW
Feng Gao, Jiemei Chen, Haibo Zhu
Endothelial dysfunction is caused by many factors, such as dyslipidemia, endoplasmic reticulum (ER) stress, and inflammation. It has been demonstrated that endothelial dysfunction is the initial process of atherosclerosis. AMP-activated protein kinase (AMPK) is an important metabolic switch that plays a crucial role in lipid metabolism and inflammation. However, recent evidence indicates that AMPK could be a target for atherosclerosis by improving endothelial function. For instance, activation of AMPK inhibits the production of reactive oxygen species induced by mitochondrial dysfunction, ER stress, and NADPH oxidase...
April 16, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29675020/systemic-inflammation-and-cardiovascular-comorbidity-in-psoriasis-patients-causes-and-consequences
#12
REVIEW
Wolf-Henning Boehncke
Psoriasis is a common inflammatory skin disease characterized by the appearance of red scaly plaques that can affect any part of the body. High prevalence, chronicity, disfiguration, disability, and associated comorbidity make it a challenge for clinicians of multiple specialties. Likewise, its complex pathogenesis, comprising inflammation, hyperproliferation, and angioneogenesis, intrigues numerous scientific disciplines, namely, immunology. From a clinical perspective, the severity of psoriasis is highlighted by its increased mortality, with cardiovascular diseases contributing the highest excess risk...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29674475/effect-of-sfrp5-secreted-frizzled-related-protein-5-on-the-wnt5a-wingless-type-family-member-5a-induced-endothelial-dysfunction-and-its-relevance-with-arterial-stiffness-in-human-subjects
#13
Yun Kyung Cho, Yu Mi Kang, Seung Eun Lee, Yoo La Lee, So Mi Seol, Woo Je Lee, Joong-Yeol Park, Chang Hee Jung
OBJECTIVE: SFRP5 (secreted frizzled-related protein 5) is an endogenous inhibitor of WNT5A (wingless-type family member 5a), which has been implicated in atherosclerosis. However, contradictory results have been reported about the role of SFRP5 in atherosclerosis. We aimed to investigate whether SFRP5 could restore WNT5A-induced endothelial dysfunction in vitro and ex vivo. In addition, we sought to determine whether the serum concentration of SFRP5 is associated with atherosclerosis in humans...
April 19, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29674204/preeclamptic-plasma-stimulates-the-expression-of-mirnas-leading-to-a-decrease-in-endothelin-1-production-in-endothelial-cells
#14
Mayara Caldeira-Dias, Marcelo R Luizon, Elenice Deffune, Jose E Tanus-Santos, Paula P Freire, Robson F Carvalho, Heloisa Bettiol, Viviane C Cardoso, Marco Antonio Barbieri, Ricardo C Cavalli, Valéria C Sandrim
Preeclampsia is a major cause of maternal and fetal morbidity and mortality worldwide. It is a multisystem pregnancy syndrome characterized by general endothelial dysfunction caused mainly by plasma factors and debris in endothelial cells. It is widely accepted that endothelin-1 (ET-1) is involved in the pathophysiology of preeclampsia, and so it is of interest to ascertain whether the ET-1 gene (EDN1) can be targeted with tools such as miRNAs. Therefore, we investigated the relationship between the expression of miRNAs that putatively target EDN1 (and so affect ET-1 levels) in HUVECs incubated with plasma from preeclamptic women...
March 27, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673927/novel-adipokines-vaspin-and-irisin-as-risk-biomarkers-for-cardiovascular-diseases-in-type-2-diabetes-mellitus
#15
Dalia H El-Lebedy, Alshaymaa A Ibrahim, Ingy O Ashmawy
AIMS: Vaspin and irisin are novel cytokines proposed as potential new biomarkers of insulin resistance and endothelial dysfunction. This work is to investigate circulating levels of vaspin and irisin in patients with type 2 diabetes mellitus (T2DM) with and without cardiovascular disease (CVD) to study potential association with disease risk. MATERIALS AND METHODS: Circulating levels of vaspin and irisin were assayed in serum from 135 T2DM patients (with and without CVD) and 70 control subjects by ELISA...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29673628/-descemet-s-membrane-endothelial-keratoplasty-indication-surgical-technic-postoperative-management-and-review-of-literature
#16
REVIEW
V Kocaba, O Damour, C Auxenfans, C Burillon
Endothelial keratoplasty is currently the preferred method for the treatment of endothelial dysfunctions and dystrophies. Descemet Membrane Endothelial Keratoplasty (DMEK), described by Gerrit Melles in 2006, is performed by selectively replacing the damaged endothelium with a healthy counterpart. It leads to a faster visual recovery and better refractive outcomes with a limited risk of rejection compared to Descemet's Stripping Automated Endothelial Keratosplasty (DSAEK), which includes a thin stromal layer...
April 17, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29673584/a-30-minutes-supraceliac-aortic-clamping-in-the-rat-causes-death-due-to-an-inflammatory-response-and-pulmonary-lesions
#17
Antoine Monnot, Anaïs Dumesnil, Sylvanie Renet, Marie Laurence Roquet, Vincent Richard, Didier Plissonnier
BACKGROUND: The treatment of thoraco-abdominal aortic aneurysms through an open approach has general and pulmonary consequences of multiple etiologies. Our assumption was that the supraceliac aortic clamping needed for this operation causes a systemic inflammatory response associated with a pulmonary attack. MATERIAL AND METHODS: We developed a model of 30 min supraceliac aortic clamping in Wistar rats weighing 300 g. After 90 min of reperfusion the rats were sacrificed...
April 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29673469/thyroid-hormones-and-cardiovascular-function-and-diseases
#18
REVIEW
Salman Razvi, Avais Jabbar, Alessandro Pingitore, Sara Danzi, Bernadette Biondi, Irwin Klein, Robin Peeters, Azfar Zaman, Giorgio Iervasi
Thyroid hormone (TH) receptors are present in the myocardium and vascular tissue, and minor alterations in TH concentration can affect cardiovascular (CV) physiology. The potential mechanisms that link CV disease with thyroid dysfunction are endothelial dysfunction, changes in blood pressure, myocardial systolic and diastolic dysfunction, and dyslipidemia. In addition, cardiac disease itself may lead to alterations in TH concentrations (notably, low triiodothyronine syndrome) that are associated with higher morbidity and mortality...
April 24, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29673103/allopurinol-and-endothelial-function-a-systematic-review-with-meta-analysis-of-randomized-controlled-trials
#19
Manal M Alem
AIM: Oxidative stress and endothelial dysfunction are two inter-related conditions commonly seen in patients with cardiovascular risk factors. The enzyme, xanthine oxidase, is an important contributor to these phenomena but to a variable degree in different patient populations. This meta-analysis will summarize the effect of allopurinol, an established xanthine oxidase inhibitor, on endothelial function among patients with different co-morbidities. METHODS: Medline Complete, PubMed, ProQuest, ClinicalKey, Wiley Online Library and Cochrane Central Register of Controlled Trials were searched till 29th July, 2017...
April 19, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29672927/interleukin-33-contributes-to-ilc2-activation-and-early-inflammation-associated-lung-injury-during-abdominal-sepsis
#20
Hui Xu, Jing Xu, Li Xu, Shuqing Jin, Heth R Turnquist, Rosemary Hoffman, Patricia Loughran, Timothy R Billiar, Meihong Deng
Sepsis is defined as infection with organ dysfunction due to a dysregulated immune response. The lung is one of the most vulnerable organs at the onset of sepsis. Interleukin-33 (IL-33) can be released by injured epithelial and endothelial cells in the lung and regulate immune activation and infiltration. Therefore, we postulated that IL-33 would contribute to the immune response in the lung during sepsis. Using the cecal ligation and puncture (CLP) sepsis model, we show here that IL-33 contributes significantly to both sepsis-induced inflammation in the lung and systemic inflammatory response in the early phase of sepsis...
April 19, 2018: Immunology and Cell Biology
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