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Endothelial dysfunction

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https://www.readbyqxmd.com/read/28230336/the-endothelial-border-to-health-mechanistic-evidence-of-the-hyperglycemic-culprit-of-inflammatory-disease-acceleration
#1
REVIEW
Nina Waerling Hansen, Anker Jon Hansen, Anette Sams
The endothelial cell (EC) layer constitutes a barrier that controls movements of fluid, solutes and cells between blood and tissue. Further, the endothelial layer regulates vascular tone and directs local humoral and cellular inflammatory processes. The strategic position makes it an important player for maintenance of health and for development of a number of diseases. Endothelial dysfunction is known to be an important component of type 2 diabetes, but is also assumed to be involved in many other diseases, for example, rheumatoid arthritis, inflammatory bowel disease, asthma, and cardiovascular diseases...
March 2017: IUBMB Life
https://www.readbyqxmd.com/read/28229431/hypertensive-disorders-of-pregnancy
#2
REVIEW
Sahar Naderi, Sandra A Tsai, Abha Khandelwal
PURPOSE OF REVIEW: Although pregnancy-related deaths are rare in the USA, they are on the rise and have more than doubled in the last 20 years. A substantial portion of these deaths are related to cardiovascular disease, specifically hypertensive disorders of pregnancy (HDP). In this review, we will discuss the definitions and proposed pathophysiology of HDP as well as its potential role in cardiovascular morbidity and mortality. RECENT FINDINGS: Placental hypoperfusion may lead to an imbalance in proangiogenic and antiangiogenic factors, notably an increase in soluble fms-like tyrosine kinsase-1 (sFlt-1), thereby leading to endothelial dysfunction...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28229321/cerebral-endothelial-dysfunction-in-reversible-cerebral-vasoconstriction-syndrome-a-case-control-study
#3
Hyun Ah Choi, Mi Ji Lee, Chin-Sang Chung
BACKGROUND: The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS). METHODS: We prospectively recruited patients with RCVS, age-matched controls with episodic migraine, and age-matched healthy controls at Samsung Medical Center from Apr 2015 to Jul 2016. All participants underwent transcranial Doppler evaluation, with a breath-holding maneuver, for the evaluation of bilateral middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), and the basilar artery (BA)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28229168/cd14-cd16-nonclassical-monocytes-are-associated-with-endothelial-dysfunction-in-patients-with-coronary-artery-disease
#4
Karol Urbanski, Dominik Ludew, Grzegorz Filip, Magdalena Filip, Agnieszka Sagan, Piotr Szczepaniak, Grzegorz Grudzien, Jerzy Sadowski, Barbara Jasiewicz-Honkisz, Tomasz Sliwa, Boguslaw Kapelak, Eilidh McGinnigle, Tomasz Mikolajczyk, Tomasz J Guzik
Endothelial dysfunction and inflammation are key mechanisms of vascular disease. We hypothesised that heterogeneity of monocyte subpopulations may be related to the development of vascular dysfunction in coronary artery disease (CAD). Therefore, we examined the relationships between monocyte subsets (CD14(++)CD16(-) "classical - Mon1", CD14(++)CD16(+) "intermediate - Mon2" and CD14(+)CD16(++) "nonclassical - Mon3"), endothelial function and risk factor profiles in 130 patients with CAD undergoing coronary artery bypass grafting...
February 23, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28228970/comparison-of-endothelial-function-improvement-estimated-with-reactive-hyperemia-index-between-ramipril-and-telmisartan-in-hypertensive-patients
#5
You-Jeong Ki, Jae-Bin Seo, Hack-Lyoung Kim, Woo-Hyun Lim, Hye Yeon Seo, Jin Yong Lee, Woo-Young Chung
BACKGROUND: Endothelium has a function to regulate vascular tone by releasing mediators either vasodilating or vasoconstricting blood vessels. Endothelial dysfunction can be measured conveniently by Reactive Hyperemia Index (RHI) with a peripheral arterial tonometry. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II (AT II) receptor blockers (ARBs) are considered to have beneficial effects on endothelium through inhibition of AT II. This study was performed to compare the effect of ACEIs or ARBs on endothelial function estimated by RHI in hypertensive patients...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28228736/stress-signal-network-between-hypoxia-and-er-stress-in-chronic-kidney-disease
#6
REVIEW
Hiroshi Maekawa, Reiko Inagi
Chronic kidney disease (CKD) is characterized by an irreversible decrease in kidney function and induction of various metabolic dysfunctions. Accumulated findings reveal that chronic hypoxic stress and endoplasmic reticulum (ER) stress are involved in a range of pathogenic conditions, including the progression of CKD. Because of the presence of an arteriovenous oxygen shunt, the kidney is thought to be susceptible to hypoxia. Chronic kidney hypoxia is induced by a number of pathogenic conditions, including renal ischemia, reduced peritubular capillary, and tubulointerstitial fibrosis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28228404/endothelial-colony-forming-cells-ameliorate-endothelial-dysfunction-via-secreted-factors-following-ischemia-reperfusion-injury
#7
Jason A Collett, Purvi Mehrotra, Allison Crone, W Christopher Shelley, Mervin C Yoder, David P Basile
Damage to endothelial cells contributes to acute kidney injury (AKI) by leading to impaired perfusion. Endothelial colony-forming cells (ECFCs) are endothelial precursor cells with high proliferative capacity, pro-angiogenic activity, and in vivo vessel forming potential. We hypothesized that ECFCs may ameliorate the degree of AKI and/or promote repair of the renal vasculature following ischemia/reperfusion (I/R). Rat pulmonary microvascular ECs (PMVEC) with high proliferative potential were compared with pulmonary artery ECs (PAEC) with low proliferative potential in rats subjected to renal I/R...
February 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28228349/identification-of-prdm-genes-in-human-corneal-endothelium
#8
Kostadin Rolev, G O'Donovan Dominic, Christiana Georgiou, Rajan Madhavan, Alexandra Chittka
Corneal endothelial cells (CECs) are essential for maintaining corneal stromal hydration and ensuring its transparency, which is necessary for normal vision. Dysfunction of CECs leads to stromal decompensation, loss of transparency and corneal blindness. Corneal endothelium has low proliferative potential compared to surface epithelial cells leading to poor regeneration of CEC following injury or age related decline in cellular density. The mechanisms which control proliferation and differentiation of neural crest derived CEC progenitors are yet to be clearly elucidated...
February 19, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28228072/curcumin-and-endothelial-function-evidence-and-mechanisms-of-protective-effects
#9
Maryam Saberi Karimian, Matteo Pirro, Thomas P Johnston, Muhammed Majeed, Amirhossein Sahebkar
BACKGROUND: The endothelium is a large paracrine organ regulating cell growth, vascular tone and thrombogenicity as well as platelet and leukocyte interactions. Endothelial function can be assessed by non-invasive techniques [e.g. flow-mediated vasodilation, nitroglycerin-mediated dilation and pulse wave velocity] and measuring specific circulating biomarkers [cell adhesion molecules, endothelial microparticles and endothelial progenitor cells]. Impaired endothelial function plays a key role in the development of atherosclerosis, arterial hypertension, heart failure, ischemia-reperfusion injury, Alzheimer's disease and other conditions...
February 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28225990/visceral-adiposity-index-and-triglyceride-high-density-lipoprotein-cholesterol-ratio-in-hypogonadism
#10
Cem Haymana, Alper Sonmez, Aydogan Aydogdu, Serkan Tapan, Yalcin Basaran, Coskun Meric, Kamil Baskoy, Mustafa Dinc, Mahmut Yazici, Abdullah Taslipinar, Cem Barcin, Mahmut Ilker Yilmaz, Erol Bolu, Omer Azal
Background: Cardiometabolic risk is high in patients with hypogonadism. Visceral adiposity index (VAI) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio are the practical markers of atherosclerosis and insulin resistance and independent predictors of cardiaovascular risk. To date, no study has evaluated VAI levels and TG/HDL-C ratio in hypogonadism. Subjects and methods: A total of 112 patients with congenital hypogonadotrophic hypogonadism (CHH) (mean age, 21...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28225475/stretching-exercises-improve-vascular-endothelial-dysfunction-through-attenuation-of-oxidative-stress-in-chronic-heart-failure-patients-with-an-implantable-cardioverter-defibrillator
#11
Michitaka Kato, Takashi Masuda, Michio Ogano, Kazuki Hotta, Hisato Takagi, Shinya Tanaka, Yumi Kamada, Ayako Akiyama, Daisuke Kamekawa, Ryosuke Shimizu, Minoru Tabata, Jun Tanabe, Takuya Umemoto
PURPOSE: Endurance training improves oxidative stress and vascular endothelial dysfunction in patients with chronic heart failure (CHF). However, patients with CHF and an implantable cardioverter defibrillator (ICD) or cardiac resynchronization therapy-defibrillator (CRT-D) often avoid endurance training for fear of ICD shock. Recent studies have reported that stretching exercises enhance antioxidant activity and improve vascular responses. Therefore, we aimed to assess the effects of 4 weeks of stretching exercises on oxidative stress and vascular endothelial function in patients with CHF with an ICD or CRT-D...
March 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28225018/choline-ameliorates-cardiovascular-damage-by-improving-vagal-activity-and-inhibiting-the-inflammatory-response-in-spontaneously-hypertensive-rats
#12
Longzhu Liu, Yi Lu, Xueyuan Bi, Man Xu, Xiaojiang Yu, Runqing Xue, Xi He, Weijin Zang
Autonomic dysfunction and abnormal immunity lead to systemic inflammatory responses, which result in cardiovascular damage in hypertension. The aim of this report was to investigate the effects of choline on cardiovascular damage in hypertension. Eight-week-old male spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats were intraperitoneally injected with choline or vehicle (8 mg/kg/day). After 8 weeks, choline restored the cardiac function of the SHRs, as evidenced by decreased heart rate, systolic blood pressure, left ventricle systolic pressure, and ±dp/dtmax and increased ejection fraction and fractional shortening...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224405/complications-of-acromegaly-cardiovascular-respiratory-and-metabolic-comorbidities
#13
REVIEW
Rosario Pivonello, Renata S Auriemma, Ludovica F S Grasso, Claudia Pivonello, Chiara Simeoli, Roberta Patalano, Mariano Galdiero, Annamaria Colao
Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory complications representing not only the most frequent comorbidities but also two of the main causes of deaths, whereas a minor role is played by metabolic complications, and particularly diabetes mellitus. The most prevalent cardiovascular complications of acromegaly include a cardiomyopathy, characterized by cardiac hypertrophy and diastolic and systolic dysfunction together with arterial hypertension, cardiac rhythm disorders and valve diseases, as well as vascular endothelial dysfunction...
February 21, 2017: Pituitary
https://www.readbyqxmd.com/read/28224261/determination-of-glucose-exchange-rates-and-permeability-of-erythrocyte-membrane-in-preeclampsia-and-subsequent-oxidative-stress-related-protein-damage-using-dynamic-19-f-nmr
#14
Elizabeth Dickinson, John R P Arnold, Julie Fisher
The cause of the pregnancy condition preeclampsia (PE) is thought to be endothelial dysfunction caused by oxidative stress. As abnormal glucose tolerance has also been associated with PE, we use a fluorinated-mimic of this metabolite to establish whether any oxidative damage to lipids and proteins in the erythrocyte membrane has increased cell membrane permeability. Data were acquired using (19)F Dynamic-NMR (DNMR) to measure exchange of 3-fluoro-3-deoxyglucose (3-FDG) across the membrane of erythrocytes from 10 pregnant women (5 healthy control women, and 5 from women suffering from PE)...
February 21, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28224128/upregulation-of-th-il-17-pathway-related-genes-in-human-coronary-endothelial-cells-stimulated-with-serum-of-patients-with-acute-coronary-syndromes
#15
Giovanni Cimmino, Loreta Pia Ciuffreda, Giovanni Ciccarelli, Paolo Calabrò, Fiorella Angelica Valeria Ferraiolo, Alessia Rivellino, Raffaele De Palma, Paolo Golino, Francesco Rossi, Plinio Cirillo, Liberato Berrino
BACKGROUND: Inflammation plays an essential role in the development and complications of atherosclerosis plaques, including acute coronary syndromes (ACS). Indeed, previous reports have shown that within the coronary circulation of ACS patients, several soluble mediators are released. Moreover, it has been demonstrated that endothelial dysfunction might play an important role in atherosclerosis as well as ACS pathophysiology. However, the mechanisms by which these soluble mediators might affect endothelial functions are still largely unknown...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28223818/an-evidence-based-review-on-urate-lowering-treatments-implications-for-optimal-treatment-of-chronic-hyperuricemia
#16
REVIEW
Marilisa Bove, Arrigo Francesco Giuseppe Cicero, Maddalena Veronesi, Claudio Borghi
Several studies suggest that chronic hyperuricemia, the main precursor of gout, is involved in the pathogenesis of different systemic disorders that affect cardiovascular and renal systems, such as hypertension, obesity, hypercholesterolemia, atherosclerosis, metabolic syndrome, chronic heart failure, and chronic kidney disease. Recent epidemiological evidence has shown an increasing trend in the prevalence of hyperuricemia and gout in the Western world: a number of population-based studies estimate a prevalence of up to 21% for hyperuricemia and 1%-4% for gout...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28223216/mir-181c-restrains-nitration-stress-of-endothelial-cells-in-diabetic-db-db-mice-through-inhibiting-the-expression-of-foxo1
#17
Guangwei Yang, Yuanbo Wu, Shandong Ye
Endothelial dysfunction played an important role in the progression of diabetes mellitus (DM). miR-181c has been implicated in many diseases, including DM. However, the molecular mechanisms of miR-181c regulate this process remained poorly understood. Healthy ICR mice were divided into control group (n = 10) and db/db DM group (n = 10). The expression of miR-181c and FoxO1 were both investigated in diabetic db/db mice or high glucose-induced endothelial cells (MAECs and END-D). Here we found that down-regulation of miR-181c and the activation of FoxO1/iNOS were observed in mice and endothelial cells...
February 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28222247/bile-acids-and-cardiovascular-function-in-cirrhosis
#18
Andrei Voiosu, Signe Wiese, Theodor Voiosu, Flemming Bendtsen, Søren Møller
Cirrhotic cardiomyopathy and the hyperdynamic syndrome are clinically important complications of cirrhosis but their exact pathogenesis is still partly unknown. Experimental models have proven the cardiotoxic effects of bile acidsand recent studies of their varied receptor-mediated functions offer new insight into their involvement in cardiovascular dysfunction in cirrhosis. Bile acid receptors such as farnesoid X-activated receptor and TGR5 are currently under investigation as potential therapeutic targets in a variety of pathological conditions...
February 21, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28220786/intrauterine-zika-virus-infection-of-pregnant-immunocompetent-mice-models-transplacental-transmission-and-adverse-perinatal-outcomes
#19
Meghan S Vermillion, Jun Lei, Yahya Shabi, Victoria K Baxter, Nathan P Crilly, Michael McLane, Diane E Griffin, Andrew Pekosz, Sabra L Klein, Irina Burd
Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine inoculation at embryonic day (E) 10, but not E14, with African, Asian or American strains of ZIKV reduces fetal viability and increases infection of placental and fetal tissues. ZIKV inoculation at E10 causes placental inflammation, placental dysfunction and reduces neonatal brain cortical thickness, which is associated with increased activation of microglia...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28220370/the-effect-of-candesartan-on-pentraxin-3-plasma-levels-as-marker-of-endothelial-dysfunction-in-patients-with-essential-arterial-hypertension
#20
V Buda, M Andor, C Cristescu, M Voicu, F Cochera, P Tuduce, L Petrescu, M C Tomescu
BACKGROUND: In the last decades, the studies performed on the field of endothelial dysfunction confirmed the fact that the starting point of this pathology is the inflammation. Several inflammatory biomarkers had been discovered and studied, ones showing systemic inflammation, and others being more specific biomarkers and showing the local inflammation. Pentraxin-3 (PTX3) is a new inflammatory biomarker, from the same family as high-selectivity C-reactive protein (hs-CRP), but it is a more specific biomarker, due to its local production: the endothelial cells and not the liver like in the case of hs-CRP...
February 21, 2017: Irish Journal of Medical Science
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