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https://www.readbyqxmd.com/read/29244733/the-association-of-triiodothyronine-to-thyroxine-ratio-with-body-mass-index-in-obese-nigerian-children-and-adolescents
#1
Mathias Abiodun Emokpae, Progress Arhenrhen Obazelu
The interest in the relationship between thyroid dysfunction and obesity is on the increase. This study compares the triiodothyronine-to-thyroxine (T3/T4) ratio in obese and lean children and adolescents, and correlates thyroid hormones with body mass index (BMI) in obese Nigerian children. It is a retrospective study of records of 76 obese children and adolescents with a BMI of 31.7 ± 0.1 kg/m² (26 males aged 10.9 ± 0.35 years, and 50 females aged 10.8 ± 0.4 years) that were referred to the laboratory for thyroid hormone evaluation because of their obese status...
December 15, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29243843/signaling-cascades-in-thyroid-cancer-increasing-the-armory-of-archers-to-hit-bullseye
#2
Faiza Abdul Rashid, Qaisar Mansoor, Hafsa Aziz, Sobia Tabassum, Waleed O Arfat, George E Naoum, Muhammad Ismail, Ammad Ahmad Farooqi
Thyroid cancer is a multifaceted and therapeutically challenging disease and rapidly accumulating experimentally verified findings have considerably improve our understanding of the molecular mechanisms which underlie its development. Substantial fraction of information has been added into existing landscape of molecular oncology and we have started to develop a sharper understanding of the underlying mechanisms of thyroid cancer. Wealth of information demystified different intracellular signaling cascades which are frequently deregulated in thyroid cancer...
December 15, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29243735/orbital-decompression-for-thyroid-eye-disease-methods-outcomes-and-complications
#3
J M Jefferis, R K Jones, Z I Currie, J H Tan, S M Salvi
PurposeTo determine the safety and effectiveness of orbital decompression for thyroid eye disease (TED) in our unit. To put this in the context of previously published literature.Patients and methodsA retrospective case review of all patients undergoing orbital decompression for TED under the care of one orbital surgeon (SMS) between January 2009 and December 2015. A systematic literature review of orbital decompression for TED.ResultsWithin the reviewed period, 93 orbits of 55 patients underwent decompression surgery for TED...
December 15, 2017: Eye
https://www.readbyqxmd.com/read/29243502/evidence-based-management-of-incidental-focal-uptake-of-fluorodeoxyglucose-on-pet-ct
#4
Deborah Pencharz, Malavika Nathan, Thomas L Wagner
Focal incidental uptake, with or without CT abnormalities, is a common finding on FDG PET/CT and evidence based management for this type of uptake is lacking. This article reviews the evidence on focal incidental uptake including the incidence of malignancy, differential diagnosis and imaging criteria which can be used to further characterise it. The article focusses on PET rather than CT criteria. The strength of the evidence base is highly variable ranging from systematic reviews and meta-analyses to a virtual absence of evidence...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29243180/transoral-thyroidectomy-a-viable-surgical-option-with-unprecedented-complications-a-case-series
#5
S Bakkar, M Al Hyari, M Naghawi, C Corsini, P Miccoli
PURPOSE: To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS: From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the need to convert to cervicotomy, the length of hospital stay and post-operative pain and morbidity. Unconventional complications regarded as specific for TOETVA were reported...
December 14, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29243128/measurement-of-131i-activity-in-air-indoor-polish-nuclear-medical-hospital-as-a-tool-for-an-internal-dose-assessment
#6
K Brudecki, A Szczodry, T Mróz, A Kowalska, J W Mietelski
This paper presents results of 131I air activity measurements performed within nuclear medical hospitals as a tool for internal dose assessment. The study was conducted at a place of preparation and administration of 131I ("hot room") and at a nurse station. 131I activity measurements were performed for 5 and 4 consecutive working days, at the "hot room" and nurse station, respectively. Iodine from the air was collected by a mobile HVS-30 aerosol sampler combined with a gas sampler. Both the gaseous and aerosol fractions were measurement...
December 14, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29243023/lef-1-is-a-sensitive-marker-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma
#7
Shalini Mohindra, Hany Sakr, Charles Sturgis, Deborah J Chute
Cribriform morular variant of PTC (CMV-PTC) frequently shows activation of the CTNNB1/Wnt pathway with nuclear accumulation of beta catenin. The utility of LEF-1, also in the CTNNB1/WNT pathway, in the diagnosis of CMV-PTC has not been previously studied. LEF-1 immunohistochemistry was performed on seven CMV-PTC, 52 benign cases and 101 malignant thyroid neoplasms. LEF-1 was scored by stain intensity (0 = no nuclear stain, 1 = weak nuclear stain, less than lymphocyte and 2 = strong nuclear stain, intense as lymphocyte) and percentage of positive cells at each intensity, for a maximum total score of 200...
December 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29242746/a-practical-method-of-i-131-thyroid-cancer-therapy-dose-optimization-using-estimated-effective-renal-clearance
#8
Brandon A Howard, Olga G James, Jennifer M Perkins, Robert A Pagnanelli, Salvador Borges-Neto, Robert E Reiman
In thyroid cancer patients with renal impairment or other complicating factors, it is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung damage. We developed a web-based calculator based on a modified Benua and Leeper method to calculate the maximum I-131 dose to reduce the risk of these toxicities, based on the effective renal clearance of I-123 as measured from two whole-body I-123 scans, performed at 0 and 24 h post-administration.
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29242744/lung-talaromyces-marneffei-infection-in-an-indonesian-papillary-thyroid-carcinoma-patient
#9
Surya Darma, Yusrizal Djam'an Saleh, Tri Wibawa
Talaromycosis, a disseminated and progressive infection caused by Talaromyces marneffei, is highly endemic in the tropical region of Asia. However, accumulated data show very low incidence in Indonesia. Here, we report a case of papillary thyroid carcinoma with pulmonary T. marneffei infection. Screening of T. marneffei in this immunocompromised Indonesian patient is recommended even though the reported incidence of this particular fungal infection in Indonesia is low.
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29242723/spect-ct-in-the-treatment-of-differentiated-thyroid-cancer
#10
REVIEW
Sang-Woo Lee
Single-photon emission computed tomography with integrated computed tomography (SPECT/CT) systems has been applied in a wide range of clinical circumstances, and differentiated thyroid cancer (DTC) is one of the most important indications of SPECT/CT imaging. In the treatment of DTC, SPECT/CT images have been reported to have many advantages over conventional planar whole-body scintigraphy based on its precise localization and characterization of abnormal foci of radioactive iodine (RAI) accumulation, influencing the staging, risk stratification, and clinical management as well as reader confidence...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29242704/effects-of-prolonged-treatment-with-co-trimoxazole-on-the-thyroid-gland-liver-and-epididymal-sperm-reserve-in-dogs
#11
Davinson C Anyogu, Vincent So Shoyinka, John I Ihedioha
Co-trimoxazole is an antimicrobial drug gotten from potentiation of sulfamethoxazole with trimethoprim. It is widely used for the treatment of bacterial and protozoan infections in humans. It is also used in veterinary clinics against susceptible microorganisms, but thyroid dysfunction has raised concern especially in dogs. This study aimed to determine the effects of prolonged treatment with co-trimoxazole in euthyroid dogs. Dogs were given co-trimoxazole at 30, 60, and 120 mg/kg body weight at 12-hour intervals for 21 days...
2017: Clinical Medicine Insights. Pathology
https://www.readbyqxmd.com/read/29242703/clinical-characteristics-of-patients-with-renal-cell-carcinoma-and-metastasis-to-the-thyroid-gland
#12
Gregory Jackson, Nora Fino, Rhonda L Bitting
Introduction: Renal cell carcinoma (RCC) is the most common malignancy to metastasize to the thyroid gland. The aims of this study are as follows: (1) to analyze the clinical characteristics of patients with thyroid involvement of RCC and (2) in patients with RCC thyroid metastasis, to determine whether RCC metastasis to glandular organs only portends a better prognosis compared with other patterns of RCC metastasis. Methods: Patients from Wake Forest Baptist Medical Center (WFBMC) diagnosed with thyroid metastasis from RCC were identified and medical records retrospectively examined...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29242418/subclinical-hypothyroidism-a-prospective-observational-study-from-southern-india
#13
Mathrubootham Sridhar, Shriraam Mahadevan, Latha Vishwanathan, Anbezhil Subbarayan
OBJECTIVE: To assess the natural history and progression of subclinical hypothyroidism and to study factors which help predict evolution of subclinical hypothyroidism into overt hypothyroidism. METHODS: Longitudinal study in 40 children (2-16 yrs) presenting with subclinical hypothyroidism in a tertiary care unit in Chennai, India. Patients showing evidence of overt hypothyroidism or thyroid stimulating hormone ≥ 15 mIU/mL during follow-up were started on thyroxine...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29242405/digitalis-like-compounds-restore-hnis-expression-and-iodide-uptake-capacity-in-anaplastic-thyroid-cancer
#14
Marika H Tesselaar, Thomas Crezee, Imke Schuurmans, Danny Gerrits, James Nagarajah, Otto C Boerman, Ilse van Engen-van Grunsven, Johannes W A Smit, Romana T Netea-Maier, Theo S Plantinga
Purpose: Anaplastic thyroid cancer (ATC) is a rare malignancy that accounts for 1-2% of all thyroid cancers. ATC is one of the most aggressive human cancers, with rapid growth, tumor invasion and development of distant metastases. The median survival is only 5 months and the 1-year survival is less than 20%. Moreover, as a result of severe dedifferentiation including the loss of human sodium iodide symporter (hNIS) expression, radioactive iodide (RAI) therapy is ineffective. Recently, we have demonstrated beneficial effects of autophagy activating digitalis-like compounds (DLCs) on redifferentiation and concomitant restoration of iodide uptake in RAI-refractory papillary and follicular thyroid cancer cell lines...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29242360/imaging-of-anaplastic-thyroid-carcinoma
#15
S Ahmed, M P Ghazarian, M E Cabanillas, M E Zafereo, M D Williams, T Vu, D F Schomer, J M Debnam
Anaplastic thyroid carcinoma is fatal if unresectable. However, improved survival has been reported after gross total resection and multimodality therapy. In this report, we describe the contrast-enhanced high-resolution CT characteristics of anaplastic thyroid carcinoma in 57 patients. Anaplastic thyroid carcinoma presented as a large neck mass with necrosis in 82% of cases. The tumors demonstrated common extrathyroidal extension (91%). Sixty-two percent of tumors demonstrated calcification. Visceral space invasion involved the esophagus (62%), trachea (57%), and larynx (29%)...
December 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29241682/editorial-get-inspired-lessons-learned-from-evolution-of-thyroid-hormone-signaling-in-developmental-processes
#16
EDITORIAL
Robert Opitz, Josef Köhrle
No abstract text is available yet for this article.
December 25, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29241579/punicalagin-from-pomegranate-promotes-human-papillary-thyroid-carcinoma-bcpap-cell-death-by-triggering-atm-mediated-dna-damage-response
#17
Xin Yao, Xian Cheng, Li Zhang, Huixin Yu, Jiandong Bao, Haixia Guan, Rongrong Lu
Punicalagin (PUN), a component derived from pomegranate, is well known for its anticancer activity. Our previous work revealed that PUN induces autophagic cell death in papillary thyroid carcinoma cells. We hypothesized that PUN triggers DNA damage associated with cell death because DNA damage was reported as an inducer of autophagy. Our results showed that PUN treatment caused DNA breaks as evidenced by the significant enhancement in the phosphorylation of H2A.X. However, reactive oxygen species and DNA conformational alteration, 2 common inducing factors in DNA damage, were not involved in PUN-induced DNA damage...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29241377/current-and-future-immunotherapies-for-thyroid-cancer
#18
Alessandro Antonelli, Silvia Martina Ferrari, Poupak Fallahi
Cancer immunotherapies were approved in recent years, including immune checkpoint inhibitors. Experience with ipilimumab (CTLA-4 antagonist), nivolumab and pembrolizumab (PD-1 antagonists), and atezolizumab (PD-L1 antagonist) has shown that the impact on overall survival in cancer patients is paramount. Immune checkpoint inhibitors target the immune system and they can be applied across multiple cancers; the response rate is ranging from 20 to 40%. Many studies have shown that thyroid cancer (TC) cells produce cytokines and chemokines, inducing several tumor-promoting effects...
December 15, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29241201/cot-death-history-of-an-iatrogenic-disaster
#19
Michael Obladen
Since antiquity, cot death has been explained as accidental suffocation, overlaying, or smothering. Parents were blamed for neglect or drunkenness. A cage called arcuccio was invented around 1570 to protect the sleeping infant. Up to the 19th century, accidents were registered as natural causes of death. From 1830, accidental suffocation became unacceptable for physicians and legislators, and "natural" explanations for the catastrophe were sought, with parents being consoled rather than blamed. Two assumed causes had serious consequences: thymus hyperplasia was irradiated, causing thyroid cancer, and the concept of central apnea was widely accepted, which led to home monitors and distracted from epidemiological evidence...
December 15, 2017: Neonatology
https://www.readbyqxmd.com/read/29240902/dose-dependency-and-a-functional-cut-off-for-tpo-antibody-positivity-during-pregnancy
#20
Tim I M Korevaar, Victor J Pop, Layal Chaker, Mariette Goddijn, Yolanda B de Rijke, Peter H Bisschop, Maarten A Broeren, Vincent W V Jaddoe, Marco Medici, Theo J Visser, Eric A P Steegers, Tanja G Vrijkotte, Robin P Peeters
Objective: To investigate a dose-dependency of TPOAb concentrations in relation to thyroid function and premature delivery, and define a population-based, pregnancy-specific, functional cut-off for TPOAb positivity. Design: Individual participant meta-analysis of three prospective birth cohorts (Generation R, ABCD study and HAPPY study). Setting: Population-based studies in the Netherlands (2002-2014). Participants: 11 212 pregnant women (<20 weeks)...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
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