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https://www.readbyqxmd.com/read/27855375/three-circulating-lncrna-predict-early-progress-of-esophageal-squamous-cell-carcinoma
#1
Hai-Bo Hu, Hong-Ying Jie, Xiang-Xiang Zheng
BACKGROUND/AIMS: Previous studies revealed that circulating (either from plasma or serum) long non-coding RNA may predict the occurrence or prognosis of multiple human malignant tumors. In this study, we mainly explored whether circulating lncRNAs can be utilized as biomarkers predicting the development of human esophageal squamous cell carcinoma (ESCC). METHODS: LncRNA microarray was applied to screen the potential biomarkers for ESCC. Each group contained three individual plasma samples...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27770461/depletion-of-myeloid-cells-exacerbates-hepatitis-and-induces-an-aberrant-increase-in-histone-h3-in-mouse-serum
#2
Xuehua Piao, Soh Yamazaki, Sachiko Komazawa-Sakon, Sanae Miyake, Osamu Nakabayashi, Takeyuki Kurosawa, Tetsuo Mikami, Minoru Tanaka, Nico Van Rooijen, Masaki Ohmuraya, Akira Oikawa, Yuko Kojima, Soichiro Kakuta, Yasuo Uchiyama, Masato Tanaka, Hiroyasu Nakano
: Tissue-resident macrophages and bone marrow (BM)-derived monocytes play a crucial role in the maintenance of tissue homeostasis; however, their contribution to recovery from acute tissue injury is not fully understood. To address this issue, we generated an acute murine liver injury model using hepatocyte-specific Cflar-deficient (Cflar(Hep-low) ) mice. Cellular FLICE-inhibitory protein expression was down-regulated in Cflar-deficient hepatocytes, which thereby increased susceptibility of hepatocytes to death receptor-induced apoptosis...
October 22, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27721066/short-form-flice-inhibitory-protein-promotes-tnf%C3%AE-induced-necroptosis-in-fibroblasts-derived-from-cflars-transgenic-mice
#3
Ryodai Shindo, Soh Yamazaki, Masaki Ohmuraya, Kimi Araki, Hiroyasu Nakano
Cellular FLICE-inhibitory protein (cFLIP) is a catalytically inactive homolog of the initiator caspase, caspase 8 and blocks apoptosis through binding to caspase 8. Human CFLAR gene encodes two proteins, a long form cFLIP (cFLIPL) and a short form cFLIP (cFLIPs) due to an alternative splicing. Recent studies have shown that expression of cFLIPs, but not cFLIPL promotes programmed necrosis (also referred to as necroptosis) in an immortalized human keratinocyte cell line, HaCaT. Here, we found that expression of cFLIPs similarly promoted necroptosis in immortalized fibroblasts...
October 6, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27690003/decreased-expression-of-srsf2-splicing-factor-inhibits-apoptotic-pathways-in-renal-cancer
#4
Hanna Kędzierska, Piotr Popławski, Grażyna Hoser, Beata Rybicka, Katarzyna Rodzik, Elżbieta Sokół, Joanna Bogusławska, Zbigniew Tański, Anna Fogtman, Marta Koblowska, Agnieszka Piekiełko-Witkowska
Serine and arginine rich splicing factor 2(SRSF2) belongs to the serine/arginine (SR)-rich family of proteins that regulate alternative splicing. Previous studies suggested that SRSF2 can contribute to carcinogenic processes. Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, highly aggressive and difficult to treat, mainly due to resistance to apoptosis. In this study we hypothesized that SRSF2 contributes to the regulation of apoptosis in ccRCC. Using tissue samples obtained from ccRCC patients, as well as independent validation on The Cancer Genome Atlas (TCGA) data, we demonstrate for the first time that expression of SRSF2 is decreased in ccRCC tumours when compared to non-tumorous control tissues...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27385439/fas-apoptosis-inhibitory-molecules-more-than-death-receptor-antagonists-in-the-nervous-system
#5
REVIEW
Laura Planells-Ferrer, Jorge Urresti, Elena Coccia, Koen M O Galenkamp, Isabel Calleja-Yagüe, Joaquín López-Soriano, Paulina Carriba, Bruna Barneda-Zahonero, Miguel F Segura, Joan X Comella
The importance of death receptor (DR) signaling in embryonic development and physiological homeostasis is well established, as is the existence of several molecules that modulate DRs function, among them Fas Apoptotis Inhibitory Molecules. Although FAIM1, FAIM2, and FAIM3 inhibit Fas-induced cell death, they are not structurally related, nor do they share expression patterns. Moreover, they inhibit apoptosis through completely different mechanisms. FAIM1 and FAIM2 protect neurons from DR-induced apoptosis and are involved in neurite outgrowth and neuronal plasticity...
October 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27186395/methyl-jasmonate-induces-apoptosis-and-pro-apoptotic-autophagy-via-the-ros-pathway-in-human-non-small-cell-lung-cancer
#6
Mutian Zhang, Ling Su, Zhenna Xiao, Xianfang Liu, Xiangguo Liu
Methyl jasmonate (MJ) is a botanical hormone that serves as a signal transduction intermediate and regulates cell death in stressed plants. MJ induces cell cycle arrest, apoptosis and non-apoptotic cell death selectively in cancer cells. However, the underlying mechanism of MJ-induced apoptosis remains unclear. In this study, we examined the molecular mechanism through which MJ induces apoptosis in human non-small cell lung cancer (NSCLC). We found that MJ triggered apoptosis via the DDIT3-TNFRSF10B-CASP axis...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27057733/atp13a2-expression-in-the-periaqueductal-gray-is-decreased-in-the-pink1-rat-model-of-parkinson-disease
#7
Cynthia A Kelm-Nelson, Sharon A Stevenson, Michelle R Ciucci
Vocal communication deficits are common in Parkinson disease (PD). Widespread alpha-synuclein pathology is a common link between familial and sporadic PD, and recent genetic rat models based on familial genetic links increase the opportunity to explore vocalization deficits and their associated neuropathologies. Specifically, the Pink1 knockout (-/-) rat presents with early, progressive motor deficits, including significant vocal deficits, at 8 months of age. Moreover, this rat model exhibits alpha-synuclein pathology compared to age-matched non-affected wildtype (WT) controls...
May 16, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27056574/developmental-checkpoints-guarded-by-regulated-necrosis
#8
REVIEW
Christopher P Dillon, Bart Tummers, Katherine Baran, Douglas R Green
The process of embryonic development is highly regulated through the symbiotic control of differentiation and programmed cell death pathways, which together sculpt tissues and organs. The importance of programmed necrotic (RIPK-dependent necroptosis) cell death during development has recently been recognized as important and has largely been characterized using genetically engineered animals. Suppression of necroptosis appears to be essential for murine development and occurs at three distinct checkpoints, E10...
June 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27042300/differential-changes-in-gene-expression-in-human-neutrophils-following-tnf-%C3%AE-stimulation-up-regulation-of-anti-apoptotic-proteins-and-down-regulation-of-proteins-involved-in-death-receptor-signaling
#9
Direkrit Chiewchengchol, Helen L Wright, Huw B Thomas, Connie W Lam, Kate J Roberts, Nattiya Hirankarn, Michael W Beresford, Robert J Moots, Steven W Edwards
Responses of human neutrophils to TNF-α are complex and multifactorial. Exposure of human neutrophils to TNF-α in vitro primes the respiratory burst, delays apoptosis and induces the expression of several genes including chemokines, and TNF-α itself. This study aimed to determine the impact of TNF-α exposure on the expression of neutrophil genes and proteins that regulate apoptosis. Quantitative PCR and RNA-Seq, identified changes in expression of several apoptosis regulating genes in response to TNF-α exposure...
March 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/26798068/balance-between-short-and-long-isoforms-of-cflip-regulates-fas-mediated-apoptosis-in-vivo
#10
Daniel R Ram, Vladimir Ilyukha, Tatyana Volkova, Anton Buzdin, Albert Tai, Irina Smirnova, Alexander Poltorak
cFLIP, an inhibitor of apoptosis, is a crucial regulator of cellular death by apoptosis and necroptosis; its importance in development is exemplified by the embryonic lethality in cFLIP-deficient animals. A homolog of caspase 8 (CASP8), cFLIP exists in two main isoforms: cFLIPL (long) and cFLIPR (short). Although both splice variants regulate death receptor (DR)-induced apoptosis by CASP8, the specific role of each isoform is poorly understood. Here, we report a previously unidentified model of resistance to Fas receptor-mediated liver failure in the wild-derived MSM strain, compared with susceptibility in C57BL/6 (B6) mice...
February 9, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26686423/network-assisted-analysis-of-primary-sj%C3%A3-gren-s-syndrome-gwas-data-in-han-chinese
#11
Kechi Fang, Kunlin Zhang, Jing Wang
Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder. So far, genetic research in pSS has lagged far behind and the underlying biological mechanism is unclear. Further exploring existing genome-wide association study (GWAS) data is urgently expected to uncover disease-related gene combination patterns. Herein, we conducted a network-based analysis by integrating pSS GWAS in Han Chinese with a protein-protein interactions network to identify pSS candidate genes. After module detection and evaluation, 8 dense modules covering 40 genes were obtained for further functional annotation...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26440064/identification-of-functional-networks-associated-with-cell-death-in-the-retina-of-oxys-rats-during-the-development-of-retinopathy
#12
Darya V Telegina, Elena E Korbolina, Nikita I Ershov, Nataliya G Kolosova, Oyuna S Kozhevnikova
Age-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of early events in AMD is poorly understood. Senescence-accelerated OXYS rats develop AMD-like retinopathy. The aim of this study was to explore the differences in retinal gene expression between OXYS and Wistar (control) rats at age 20 d and to identify the pathways of retinal cell death involved in the OXYS retinopathy initiation and progression. Retinal mRNA profiles of 20-day-old OXYS and Wistar rats were generated at the sequencing read depth 40 mln, in triplicate, using Illumina GAIIx...
2015: Cell Cycle
https://www.readbyqxmd.com/read/26392551/cd31-signals-confer-immune-privilege-to-the-vascular-endothelium
#13
Kenneth Cheung, Liang Ma, Guosu Wang, David Coe, Riccardo Ferro, Marco Falasca, Christopher D Buckley, Claudio Mauro, Federica M Marelli-Berg
Constitutive resistance to cell death induced by inflammatory stimuli activating the extrinsic pathway of apoptosis is a key feature of vascular endothelial cells (ECs). Although this property is central to the maintenance of the endothelial barrier during inflammation, the molecular mechanisms of EC protection from cell-extrinsic, proapoptotic stimuli have not been investigated. We show that the Ig-family member CD31, which is expressed by endothelial but not epithelial cells, is necessary to prevent EC death induced by TNF-α and cytotoxic T lymphocytes in vitro...
October 27, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26389741/analysis-of-immunological-viral-genetic-and-environmental-factors-that-might-be-associated-with-decreased-susceptibility-to-hiv-infection-in-serodiscordant-couples-in-florian%C3%A3-polis-southern-brazil
#14
Íris M Santos, Elis A da Rosa, Tiago Gräf, Luiz G E Ferreira, Andrea Petry, Fernanda Cavalheiro, Edna M Reiche, Carlos R Zanetti, Aguinaldo R Pinto
Individuals who have been exposed to human immunodeficiency virus (HIV) and have not been infected might possess natural resistance mechanisms. An understanding of the sociodemographic and immunological conditions that influence resistance to HIV is a challenge, and very little is known about the role of intrinsic antiviral factors that restrict HIV infection. The aim of this study was to analyze potential factors responsible for resistance to HIV infection in serodiscordant couples by comparing HIV-exposed seronegative individuals (HESN) to HIV-seropositive individuals treated with antiretroviral therapy (HIV-ART) along with healthy controls (HC)...
November 2015: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/26279947/histone-deacetylase-inhibition-protects-hearing-against-acute-ototoxicity-by-activating-the-nf-%C3%AE%C2%BAb-pathway
#15
W S Layman, D M Williams, J A Dearman, M A Sauceda, J Zuo
Auditory hair cells have repeatedly been shown to be susceptible to ototoxicity from a multitude of drugs including aminoglycoside antibiotics. Here, we found that systemic HDAC inhibition using suberoylanilide hydroxamic acid (SAHA) on adult mice offers almost complete protection against hair cell loss and hearing threshold shifts from acute ototoxic insult from kanamycin potentiated with furosemide. We also found that the apparent lack of hair cell loss was completely independent of spontaneous or facilitated (ectopic Atoh1 induction) hair cell regeneration...
2015: Cell Death Discovery
https://www.readbyqxmd.com/read/26121980/genome-wide-association-analysis-identified-splicing-single-nucleotide-polymorphism-in-cflar-predictive-of-triptolide-chemo-sensitivity
#16
Lata Chauhan, Gregory D Jenkins, Neha Bhise, Tanya Feldberg, Taraswi Mitra-Ghosh, Brooke L Fridley, Jatinder K Lamba
BACKGROUND: Triptolide is a therapeutic diterpenoid derived from the Chinese herb Tripterygium wilfordii Hook f. Triptolide has been shown to induce apoptosis by activation of pro-apoptotic proteins, inhibiting NFkB and c-KIT pathways, suppressing the Jak2 transcription, activating MAPK8/JNK signaling and modulating the heat shock responses. RESULTS: In the present study, we used lymphoblast cell lines (LCLs) derived from 55 unrelated Caucasian subjects to identify genetic markers predictive of cellular sensitivity to triptolide using genome wide association study...
June 30, 2015: BMC Genomics
https://www.readbyqxmd.com/read/25922834/nod-like-receptor-signaling-in-cholesteatoma
#17
Anke Leichtle, Christin Klenke, Joerg Ebmeyer, Markus Daerr, Karl-Ludwig Bruchhage, Anna Sophie Hoffmann, Allen F Ryan, Barbara Wollenberg, Holger Sudhoff
Background. Cholesteatoma is a destructive process of the middle ear resulting in erosion of the surrounding bony structures with consequent hearing loss, vestibular dysfunction, facial paralysis, or intracranial complications. The etiopathogenesis of cholesteatoma is controversial but is associated with recurrent ear infections. The role of intracellular innate immune receptors, the NOD-like receptors, and their associated signaling networks was investigated in cholesteatoma, since mutations in NOD-like receptor-related genes have been implicated in other chronic inflammatory disorders...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25577277/chronic-hepatitis-c-virus-infection-triggers-spontaneous-differential-expression-of-biosignatures-associated-with-t-cell-exhaustion-and-apoptosis-signaling-in-peripheral-blood-mononucleocytes
#18
Muttiah Barathan, Kaliappan Gopal, Rosmawati Mohamed, Rada Ellegård, Alireza Saeidi, Jamuna Vadivelu, Abdul W Ansari, Hussin A Rothan, M Ravishankar Ram, Keivan Zandi, Li Y Chang, Ramachandran Vignesh, Karlhans F Che, Adeeba Kamarulzaman, Vijayakumar Velu, Marie Larsson, Tunku Kamarul, Esaki M Shankar
Persistent hepatitis C virus (HCV) infection appears to trigger the onset of immune exhaustion to potentially assist viral persistence in the host, eventually leading to hepatocellular carcinoma. The role of HCV on the spontaneous expression of markers suggestive of immune exhaustion and spontaneous apoptosis in immune cells of chronic HCV (CHC) disease largely remain elusive. We investigated the peripheral blood mononuclear cells of CHC patients to determine the spontaneous recruitment of cellular reactive oxygen species (cROS), immunoregulatory and exhaustion markers relative to healthy controls...
April 2015: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/25331537/nanosecond-pulsed-electric-fields-modulate-the-expression-of-fas-cd95-death-receptor-pathway-regulators-in-u937-and-jurkat-cells
#19
Larry E Estlack, Caleb C Roth, Gary L Thompson, William A Lambert, Bennett L Ibey
In this publication, we demonstrate that exposure of Jurkat and U937 cells to nanosecond pulsed electrical fields (nsPEF) can modulate the extrinsic-mediated apoptotic pathway via the Fas/CD95 death receptor. An inherent difference in survival between these two cell lines in response to 10 ns exposures has been previously reported (Jurkat being more sensitive to nsPEF than U937), but the reason for this sensitivity difference remains unknown. We found that exposure of each cell line to 100, 10 ns pulses at 50 kV/cm caused a marked increase in expression of cFLIP (extrinsic apoptosis inhibitor) in U937 and FasL (extrinsic apoptosis activator) in Jurkat, respectively...
December 2014: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/25218824/hsa-mir-1246-hsa-mir-320a-and-hsa-mir-196b-5p-inhibitors-can-reduce-the-cytotoxicity-of-ebola-virus-glycoprotein-in-vitro
#20
MiaoMiao Sheng, Ying Zhong, Yang Chen, JianChao Du, XiangWu Ju, Chen Zhao, GuiGen Zhang, LiFang Zhang, KangTai Liu, Ning Yang, Peng Xie, DangSheng Li, Michael Q Zhang, ChengYu Jiang
Ebola virus (EBOV) causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91% in Zaire, the most lethal strain. Though the viral envelope glycoprotein (GP) mediates widespread inflammation and cellular damage, these changes have mainly focused on alterations at the protein level, the role of microRNAs (miRNAs) in the molecular pathogenesis underlying this lethal disease is not fully understood. Here, we report that the mi-RNAs hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells (HUVECs) following expression of EBOV GP...
October 2014: Science China. Life Sciences
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