Jing-Rui Yi, Nian-Nian Zhong, Hao Lin, Xuan-Hao Liu, Ying Yang, Bing Liu, Qi Wen Man
Oral and maxillofacial tumors pose a significant clinical challenge due to their tendency to recur, despite advancements in surgical removal techniques. The jaw's intricate structure further complicates treatments and affects patient quality of life. Consequently, emphasis has shifted towards pharmacological interventions, to potentially reduce invasive surgical procedures. One promising approach targets BRAF mutations, specifically the common V600E mutation. BRAF, a critical protein kinase, regulates cell growth and differentiation via the RAS-RAF-MEK-ERK-MAP kinase pathway...
March 29, 2024: Journal of Stomatology, Oral and Maxillofacial Surgery