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Olfactory neuroblastoma

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https://www.readbyqxmd.com/read/27917732/olfactory-neuroblastoma-14-year-experience-at-an-australian-tertiary-centre-and-the-role-for-longer-term-surveillance
#1
C Schmidt, N Potter, S Porceddu, B Panizza
BACKGROUND: Olfactory neuroblastoma is a rare sinonasal malignancy, with poorly defined treatment protocols. Management at a tertiary centre was retrospectively evaluated to inform future treatment and follow up. METHODS: Cases treated with curative intent (2000-2014) were included. Data were collected, and overall and disease-free survival rates were calculated. RESULTS: Eleven cases were identified, with a median follow up of 87 months. One patient was Kadish stage A, one was stage B, eight were stage C and one was stage D...
December 5, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27882120/lutetium-177-dota-tate-therapy-for-esthesioneuroblastoma-a-case-report
#2
Juliano Guerra Sabongi, Mônica Carboni Pereira Gonçalves, Cira Danielle Casado Alves, João Alves, Cristovam Scapulatempo-Neto, Sonia Marta Moriguchi
Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare malignant tumor that accounts for 3% of all tumors of the nasal cavity. The incidence of ENB is 0.4 cases per million in the general population, and the most common symptoms are nasal obstruction and epistaxis. Previous studies have indicated the presence of somatostatin receptors in this tumor type. Common treatment strategies for ENB include resection and adjuvant radiotherapy and/or chemotherapy (combined treatment); however, the rate of recurrence is high...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27879303/smooth-muscle-tumour-of-uncertain-malignant-potential-smtump-in-the-nasal-cavity-an-incidental-finding
#3
Dipak Ranjan Nayak, Asheesh Dora Ghanpur, Apoorva N Reddy, Swati Sharma
Sino-nasal smooth muscle tumours of uncertain malignant potential (SMTUMP) are very rare neoplasms of mesenchymal origin with features in between a benign leiomyoma and a leiomyosarcoma. We report a rare case of SMTUMP in a 44-year-old woman, who presented with vague symptoms of pharyngitis. Nasal endoscopy revealed a smooth mass in left nasal cavity. Contrast-enhanced CT and MRI scans showed features likely to be inverted papilloma or olfactory neuroblastoma or meningioma. Excision was planned and intraoperatively, frozen section revealed a probable spindle cell lesion...
November 22, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27857871/sinonasal-carcinomas-with-neuroendocrine-features-histopathological-differentiation-and-treatment-outcomes
#4
Liuba Soldatova, Raewyn G Campbell, Ricardo L Carrau, Daniel M Prevedello, Paul Wakely, Bradley A Otto, Leo F Ditzel Filho
Objectives Sinonasal cancers with neuroendocrine features share similar clinical, radiological, and histopathological features; however, these tumors often exhibit varying degrees of aggressive behavior presenting significant treatment challenges. The objective of this study was to report our experience with these rare malignancies and to present a review of current literature. Methods Following institutional review board approval, the records of all patients with biopsy-proven sinonasal malignancies over a 5-year period were reviewed...
December 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27807758/olfactory-ensheathing-cell-conditioned-medium-reverts-a%C3%AE-25-35-induced-oxidative-damage-in-sh-sy5y-cells-by-modulating-the-mitochondria-mediated-apoptotic-pathway
#5
Qing-Qing Fu, Li Wei, Javier Sierra, Jian-Zhang Cheng, María Teresa Moreno-Flores, Hua You, Hua-Rong Yu
Olfactory ensheathing cells (OECs) are a type of glia from the mammalian olfactory system, with neuroprotective and regenerative properties. β-Amyloid peptides are a major component of the senile plaques characteristic of the Alzheimer brain. The amyloid beta (Aβ) precursor protein is cleaved to amyloid peptides, and Aβ25-35 is regarded to be the functional domain of Aβ, responsible for its neurotoxic properties. It has been reported that Aβ25-35 triggers reactive oxygen species (ROS)-mediated oxidative damage, altering the structure and function of mitochondria, leading to the activation of the mitochondrial intrinsic apoptotic pathway...
November 2, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27806104/long-term-prognostic-analysis-after-endoscopic-endonasal-surgery-for-olfactory-neuroblastoma-a-retrospective-study-of-13-cases
#6
Luyao Zhang, Kai Niu, Kang Zhu, Cui Xia, Jing Yan, Wei Zhao, Junrong Wei, Maoli Duan, Guoxi Zheng
OBJECTIVES: To summarize the characteristics and long-term outcomes of olfactory neuroblastoma through the analysis of 13 cases in single institution, with the assessment of treatment modality, prognostic factors. METHOD: A retrospective study of thirteen cases diagnosed as olfactory neuroblastoma and underwent combined treatments during the period 2000-2010. Statistical analysis was performed to search for prognostic factors and compared different treatment modalities...
2016: PloS One
https://www.readbyqxmd.com/read/27715372/aggressive-esthesioneuroblastoma-with-divergent-differentiation-a-taxonomic-dilemma
#7
Norman C Charles, Carisa K Petris, Eleanore T Kim
The authors describe an esthesioneuroblastoma (olfactory neuroblastoma) that occurred within the nasal cavity and brain in a 31-year-old man. Following excision, the tumor recurred in the left orbit and in mediastinal lymph nodes. Treatment included orbital excision and systemic chemotherapy. Histopathology showed a high-grade neuroepithelial tumor with positive immunohistochemical markers for neuroendocrine and epithelial components, an unusual combination raising issues concerning taxonomy.
August 12, 2016: Orbit
https://www.readbyqxmd.com/read/27644951/ini1-smarcb1-deficient-sinonasal-carcinoma-a-clinicopathologic-report-of-2-cases
#8
Jason K Wasserman, Brendan C Dickson, Bayardo Perez-Ordonez, John R de Almeida, Jonathan C Irish, Ilan Weinreb
Poorly differentiated sinonasal malignancies are amongst the hardest differential diagnoses in pathology, owing to the large number of rare entities that arise there. Complicating the matter is that most pathologists, including those with experience in head and neck pathology, have little experience in any one of these rare entities. Most patients with sinonasal carcinoma present with locally advanced disease and in the past a combination of chemotherapy, radiotherapy, and surgery would usually be recommended without the specific disease subtype playing a large part of the decision making...
September 19, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27633279/phytochemical-loaded-mesoporous-silica-nanoparticles-for-nose-to-brain-olfactory-drug-delivery
#9
Shital Lungare, Keith Hallam, Raj K S Badhan
Central nervous system (CNS) drug delivery is often hampered due to the insidious nature of the blood-brain barrier (BBB). Nose-to-brain delivery via olfactory pathways have become a target of attention for drug delivery due to bypassing of the BBB. The antioxidant properties of phytochemicals make them promising as CNS active agents but possess poor water solubility and limited BBB penetration. The primary aim of this study was the development of mesoporous silica nanoparticles (MSNs) loaded with the poorly water-soluble phytochemicals curcumin and chrysin which could be utilised for nose-to-brain delivery...
September 12, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27625887/olfactory-neuroblastoma-followed-by-emergency-surgery-for-symptomatic-intradural-spinal-metastasis-a-case-report
#10
Masatoshi Yunoki, Kenta Suzuki, Atsuhito Uneda, Kimihiro Yoshino
BACKGROUND: Olfactory neuroblastoma (ONB) is a rare, aggressive tumor of the nasal cavity. It may invade the paranasal cavities and anterior skull base locally but may also metastasize to the cervical lymph nodes, lungs, or distant central nervous system. CASE DESCRIPTION: Here, we report a case of ONB in which emergency surgery was performed for intradural spinal metastasis (ISM). The patient was a 52-year-old male who underwent surgery for ONB. The tumor extended from the nasal cavity to the intracranial space and was resected completely...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27609444/recurrent-olfactory-neuroblastoma-in-remote-leptomeninges-mimicking-intracranial-meningioma
#11
You-Sub Kim, Shin Jung, Woo-Youl Jang, Kyung-Hwa Lee, Kyung-Sub Moon, In-Young Kim
BACKGROUND: Olfactory neuroblastoma (ONB) is an uncommon neoplasm that arises from olfactory epithelium in the nasal cavity near the cribriform plate. Although local recurrence or direct extension along olfactory epithelium and metastasis to the central nervous system has been reported, remote leptomeningeal metastasis is quite rare. In our report of a leptomeningeal metastasis of ONB without recurrence of primary site, we discuss the possible pathogenesis of this rare phenomenon with a review of the literature...
September 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27601919/an-isolated-orbital-mass-with-proptosis-and-diplopia-an-uncommon-metastasis-from-intracranial-olfactory-neuroblastoma-in-a-chinese-patient
#12
Jianqin Shen, Hongguang Cui, Shi Feng
PURPOSE: Olfactory neuroblastoma (ONB) is a rare neuroectodermal malignant neoplasm that originates from the olfactory sensory epithelium. In reported cases involving the orbit, the primary neoplasms could invade the orbits through bone destruction or cranio-orbital communication anatomical structure. The present study reports a rare case of orbital metastatic tumor arising from an intracranial ONB in a Chinese patient, which is the first case demonstrating an uncommon route of ONB involving the orbit...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27576899/relationship-between-18-fdg-pet-and-different-types-of-sinonasal-malignancies
#13
Marylisa Felix-Ravelo, Ayoub Bey, Fabien Arous, Solène Paris-Grandpierre, Roger Jankowski, Duc Trung Nguyen
CONCLUSION: The sensitivity and specificity of a (18)FDG-PET scan may be different according to the histology. The SUVmax and SUV ratio may reflect the tumor's aggressive behavior. OBJECTIVES: To describe the characteristics of PET/CT scans, including the maximum standard uptake values (SUVmax), at initial diagnosis according to six main types of sinonasal malignancies: sinonasal adenocarcinoma (SNAC), sinonasal undifferentiated carcinoma (SNUC), adenoid cystic carcinoma (ACC), sinonasal malignant melanoma (SMM), olfactory neuroblastoma (ONB), and sinonasal neuroendocrine carcinoma (SNEC)...
August 31, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27543867/expression-pattern-of-isl-1-ttf-1-and-pax5-in-olfactory-neuroblastoma
#14
P Czapiewski, A Gorczyński, J Haybaeck, K Okoń, J Reszeć, W Skrzypczak, J Dzierżanowski, M Kunc, J Karczewska, W Biernat
Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated. TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63...
June 2016: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/27449859/-esthesioneuroblastoma-a-single-institution-s-experience-and-general-literature-review
#15
A Lapierre, I Selmaji, H Samlali, T Brahmi, S Yossi
PURPOSE: Olfactory neuroblastoma or esthesioneuroblastoma is a rare entity among head and neck neoplasms. In this paper, we report the experience of our institution and compare it with a comprehensive review of the literature. PATIENTS AND METHODS: We retrospectively analysed clinical and treatment data of patients referred to the Lyon Sud University Hospital (France) for histologically proven olfactive esthesioneuroblastoma. RESULTS: Ten patients treated between 1993 and 2015 have been analysed...
December 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27375694/olfactory-neuroblastoma-a-clinicopathological-experience-of-a-rare-entity-from-pakistan
#16
Saroona Haroon, Muhammad Usman Tariq, Aisha Memon, Saira Fatima, Sheema Habibul Hasan
OBJECTIVES: To present the clinicopathological experience of Olfactory Neuroblastoma (ONB) with emphasis on histopathological and immunohistochemical features. METHODS: A descriptive cross-sectional study was done on 36 cases of ONB, selected by non-probability purposive sampling. Theses cases of ONB were retrieved and reviewed from surgical pathology database of Aga Khan University Hospital reported between January 1993 and March 2015. RESULTS: Tumor size and age of presentation was wide in range without any distinct bimodal distribution...
May 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27256979/genetic-and-molecular-alterations-in-olfactory-neuroblastoma-implications-for-pathogenesis-prognosis-and-treatment
#17
Piotr Czapiewski, Michał Kunc, Johannes Haybaeck
Olfactory neuroblastoma (ONB, Esthesioneuroblastoma) is an infrequent neoplasm of the head and neck area derived from olfactory neuroepithelium. Despite relatively good prognosis a subset of patients shows recurrence, progression and/or metastatic disease, which requires additional treatment. However, neither prognostic nor predictive factors are well specified. Thus, we performed a literature search for the currently available data on disturbances in molecular pathways, cytogenetic changes and results gained by next generation sequencing (NGS) approaches in ONB in order to gain an overview of genetic alterations which might be useful for treating patients with ONB...
May 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27180059/ectopic-primary-olfactory-neuroblastoma-of-the-maxillary-sinus
#18
Margaret Holmes, Shirley Y Su, Diana Bell
Olfactory neuroblastoma (ONB) is a rare malignant tumor. Although the vast majority of cases arise in the nasal cavity, ONB is rarely reported in ectopic locations. We report a case of ONB in the maxillary sinus. A 63-year-old woman presented with left-sided nasal obstruction and epistaxis. Magnetic resonance imaging showed a nonenhancing left maxillary sinus tumor. Histologic sections showed ONB, Hyams grade IV, invading bone, skeletal muscle, and adjacent fibroadipose tissue. It is essential to be accurate when diagnosing sinonasal tumors because the differential diagnosis is broad, and one must consider the possibility of ectopic ONB, although it is rare...
June 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27168403/treatment-outcome-of-ion-beam-therapy-in-eight-patients-with-head-and-neck-cancers
#19
Jun-Ichi Ohkubo, Nobusuke Hohchi, Shoko Takeuchi, Shoji Ikezaki, Yasuhiro Kise, Hiroki Koizumi, Hideaki Suzuki
Ion beam therapy has enabled us to treat formerly untreatable malignant tumors. The aim of the present study was to investigate the long-term follow-up course of patients with head and neck cancers who received ion beam therapy. The subjects were 8 patients (3 men and 5 women aged 43-78 years) with head and neck cancers who visited our department from 2006 to 2015 and received ion beam therapy. Six patients received carbon ion beam therapy, and the other two patients received proton beam therapy. The medical records of the patients were retrospectively analyzed...
May 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27149458/recurrent-olfactory-neuroblastoma-treated-with-cetuximab-and-sunitinib-a-case-report
#20
Lizhi Wang, Yan Ding, Lai Wei, Dewei Zhao, Ruoyu Wang, Yuewei Zhang, Xuesong Gu, Zhiqiang Wang
Olfactory neuroblastoma (ONB) is a rare cancer originating in the olfactory epithelium of the nasal vault. The recurrence rate of ONB is high, as the standard treatment of surgery followed by radiotherapy and/or chemotherapy is usually unsuccessful. The use of targeted therapy based on individual genomic variations after cancer relapse has not been reported. Here, we present the case of a 44-year-old man who was diagnosed with recurrent ONB and treated with a regimen developed using whole exome sequencing. Potential targets were first identified and then matched to appropriate drugs...
May 2016: Medicine (Baltimore)
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