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Olfactory neuroblastoma

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https://www.readbyqxmd.com/read/29340776/ectopic-cushing-s-syndrome-secondary-to-olfactory-neuroblastoma
#1
Kenny Yu, Federico Roncaroli, Tara Kearney, David Ewins, Deepa Beeharry, Thomas Naylor, David Ray, Rajiv Bhalla, Kanna Gnanalingham
We present the case of a patient with Cushing's syndrome secondary to ectopic ACTH secretion. A MR of the head showed a left-sided nasal mass extending down from the cribriform plate. The patient underwent endoscopic resection with nearly complete removal of the mass. Histological examination showed an ACTH-secreting olfactory neuroblastoma (ONB). The patient's cortisol levels returned to normal range after surgery and have remained normal for over a year. ONB is a rare cause for ectopic ACTH secretion. This case highlights the diagnostic and management difficulties in patients with ectopic ACTH secretion, and provides a brief review of ONB...
January 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29324814/comprehensive-molecular-profiling-of-advanced-metastatic-olfactory-neuroblastomas
#2
Jasmina Topcagic, Rebecca Feldman, Anatole Ghazalpour, Jeffrey Swensen, Zoran Gatalica, Semir Vranic
Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. This study retrospectively evaluated 23 ONB samples profiled at Caris Life Sciences (Phoenix, Arizona) using DNA sequencing (Sanger/NGS [Illumina], n = 15) and gene fusions (Archer FusionPlex, n = 6), whole genome RNA microarray (HumanHT-12 v4 beadChip, Illumina, n = 4), gene copy number assays (chromogenic and fluorescent in situ hybridization), and immunohistochemistry...
2018: PloS One
https://www.readbyqxmd.com/read/29314070/diagnostic-reliability-of-pretreatment-biopsy-in-malignant-nasoethmoidal-tumors-a-retrospective-study-of-77-cases
#3
Alberto Schreiber, Vittorio Rampinelli, Marco Ferrari, Davide Mattavelli, Davide Farina, Simonetta Battocchio, Piero Nicolai
OBJECTIVES/HYPOTHESIS: Pretreatment biopsy is crucial in histology-based management of malignant nasoethmoidal tumors, because misdiagnosis can lead to inadequate therapeutic planning. Factors influencing the reliability of biopsy were retrospectively investigated in a tertiary referral center. STUDY DESIGN: Retrospective case series. METHODS: All patients who underwent biopsy, staging magnetic resonance, surgery, and histologic diagnosis for nasoethmoidal tumors in our hospital were retrospectively evaluated...
January 4, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29313083/-neuroendocrine-neoplasms-of-the-head-and-neck
#4
REVIEW
B Konukiewitz, A Agaimy, W Weichert, G Klöppel
Common to all neuroendocrine neoplasms (NENs), irrespective of their site of origin, is the expression of synaptophysin and chromogranin A. NENs of the head and neck region derive either from epithelial or neural/neuroectodermal tissues. The epithelial-type NENs express cytokeratins and include the well-differentiated typical and atypical carcinoids (also called low- and intermediate-grade neuroendocrine carcinomas by WHO), the poorly differentiated high-grade neuroendocrine carcinomas of small and large cell type and the mixed neuroendocrine-nonneuroendocrine neoplasms...
January 8, 2018: Der Pathologe
https://www.readbyqxmd.com/read/29226334/early-stage-olfactory-neuroblastoma-and-the-impact-of-resecting-dura-and-olfactory-bulb
#5
Ashley C Mays, Diana Bell, Renata Ferrarotto, Jack Phan, Dianna Roberts, Clifton D Fuller, Steven J Frank, Shaan M Raza, Michael E Kupferman, Franco DeMonte, Ehab Y Hanna, Shirley Y Su
OBJECTIVE: Compare outcomes of patients with olfactory neuroblastoma (ONB) without skull base involvement treated with and without resection of the dura and olfactory bulb. METHODS: Retrospective review of ONB patients treated from 1992 to 2013 at the MD Anderson Cancer Center (The University of Texas, Houston, Texas, U.S.A.). Primary outcomes were overall and disease-free survival. RESULTS: Thirty-five patients were identified. Most patients had Kadish A/B...
December 11, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29103747/the-clinicopathological-spectrum-of-olfactory-neuroblastoma-and-sinonasal-neuroendocrine-neoplasms-refinements-in-diagnostic-criteria-and-impact-of-multimodal-treatments-on-survival
#6
Mario Turri-Zanoni, Roberta Maragliano, Paolo Battaglia, Marta Giovannardi, Paolo Antognoni, Davide Lombardi, Maria Laura Morassi, Ernesto Pasquini, Paolo Tarchini, Sofia Asioli, Maria Pia Foschini, Fausto Sessa, Piero Nicolai, Paolo Castelnuovo, Stefano La Rosa
OBJECTIVES: To provide a comprehensive review of the clinical and histopathological features of olfactory neuroblastoma (ONB) and other sinonasal neuroendocrine neoplasms (NENs), in order to refine diagnostic criteria, analyze treatment outcomes, and identify prognostic factors. METHODS: Data from an Italian multi-institutional database were analyzed. Patients were treated surgically via a minimally-invasive endoscopic approach followed by adjuvant radiotherapy or radiochemotherapy...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29074286/endoscopic-surgery-of-the-olfactory-cleft
#7
R Jankowski, C Rumeau, P Gallet, D T Nguyen, A Russel, B Toussaint
The olfactory cleft is the specific site of development of many tumours (respiratory epithelial adenomatoid hamartoma, intestinal-type adenocarcinoma, neuroblastoma, inverted papilloma, glomangiopericytoma, etc.) and is also the site of CSF rhinorrhoea via the cribriform plate (cribri-rhinorrhoea). Olfactory cleft surgery must therefore be considered to be a specific type of surgery, complementary to ethmoidal labyrinth surgery and anterior skull base surgery. Olfactory cleft tumours can be resected according to five different surgical procedures: olfactory cleft mucosal resection, partial resection of the olfactory cleft, total resection of the olfactory cleft, unilateral endoscopic anterior skull base resection, and bilateral endoscopic anterior skull base resection...
October 23, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29061289/importance-of-neoadjuvant-chemotherapy-in-olfactory-neuroblastoma-treatment-series-report-and-literature-review
#8
Ricardo Bartel, Xavier Gonzalez-Compta, Enric Cisa, Francesc Cruellas, Alberto Torres, Aleix Rovira, Manel Manos
INTRODUCTION AND OBJECTIVES: Olfactory neuroblastoma (ONB) is a rare entity that constitutes less than 5% of nasosinusal malignancies. Mainstream treatment consists in surgical resection+/-adjuvant radiotherapy. By exposing results observed with apparition of new therapeutic options as neoadjuvant chemotherapy, the objective is to evaluate a series and a review of the current literature. METHODS: A retrospective review was conducted including patients diagnosed and followed-up for ONB from 2008 to 2015 in our institution...
October 20, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29056700/how-behavioral-changes-can-indicate-serious-cerebral-pathology-a-case-report-of-concomitant-olfactory-neuroblastoma-and-distemper-virus-encephalitis-in-a-swiss-shepherd-dog
#9
Dario Candini, Ilaria Biasato, Paulo Ricardo Dell'Armelina Rocha, Elena Grego, Maria Teresa Capucchio, Cristina Vercelli
Behavioral alterations in dogs are not easy to understand and cure. The situation is more difficult when an encephalitis due to Canine Distemper Virus (CDV) and a concomitant olfactory neuroblastoma are present. This case report deals with the story of a 5-year-old Swiss shepherd dog with behavioral changes, seizures, epistaxis and ataxia. Following clinical and laboratory exams, a suspected diagnosis of CDV infection was hypothesized, and a therapy based on Ω-interferon was administered. Every supporting therapy failed and the worsening of the clinical conditions led to the euthanasia of the patient...
August 28, 2017: Veterinary Sciences
https://www.readbyqxmd.com/read/29031735/the-temporal-expression-profile-of-a-nos3-related-natural-antisense-rna-in-the-brain-suggests-a-possible-role-in-neurogenesis
#10
Gabriela G Chavez, Gabriella Taylor, Jekaterina Garaliene, Guy P Richardson, Sergei A Korneev
Experimental work over the past several years has revealed an unexpected abundance of long natural antisense transcripts (NATs) in eukaryotic species. In light of the proposed role of such RNA molecules in the regulation of gene expression in the brain, attention is now focused on specific examples of neuronal NATs. Of particular interest are NATs that are complementary to mRNAs encoding nitric oxide synthase (NOS), the enzyme responsible for production of the important gaseous neurotransmitter nitric oxide (NO)...
October 12, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28945299/survival-outcomes-for-stage-matched-endoscopic-and-open-resection-of-olfactory-neuroblastoma
#11
Richard J Harvey, Sunny Nalavenkata, Raymond Sacks, Nithin D Adappa, James N Palmer, Michael T Purkey, Rodney J Schlosser, Carl Snyderman, Eric W Wang, Bradford A Woodworth, Robert Smee, Tom Havas, Richard Gallagher
BACKGROUND: Advanced-stage olfactory neuroblastoma requires multimodal therapy for optimal outcomes. Debate exists over endoscopic endonasal surgery in this situation. Stage-matched open and endoscopic surgical therapy were compared. METHODS: Patients from 6 cancer institutions were assessed. Stratification included dural involvement, Kadish stage, nodal disease, Hyams' grade, approach, and margin status. At follow-up, local control, nodal status, and evidence of distant metastases were recorded with any subsequent therapy...
September 25, 2017: Head & Neck
https://www.readbyqxmd.com/read/28833165/volumetric-analysis-of-olfactory-neuroblastoma-skull-base-laterality-and-implications-on-neck-disease
#12
John P Marinelli, Jamie J Van Gompel, Michael J Link, Eric J Moore, Daniel L Price, Katherine A Lees, Mark W Kaczor, Jeffrey R Janus
OBJECTIVE: To determine if the laterality of primary tumors in patients with olfactory neuroblastoma (ONB) influenced the pattern and development of neck disease. METHODS: Using a retrospective cohort study design from 1994 to 2015, the primary tumors of patients who either presented with or developed neck disease were volumetrically analyzed using iPlan software (version 3.0.0, BrainLAB, Feldkirchen, Germany) by two independent observers. Agreement of volume-derived sidedness was assessed with a kappa statistic, whereas agreement in volume-derived degree of tumor laterality was evaluated with an intraclass correlation coefficient...
August 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28775129/comprehensive-molecular-profiling-of-olfactory-neuroblastoma-identifies-potentially-targetable-fgfr3-amplifications
#13
Lorena Lazo de la Vega, Jonathan B McHugh, Andi K Cani, Komal Kunder, Frances M Walocko, Chia-Jen Liu, Daniel H Hovelson, Dan Robinson, Arul M Chinnaiyan, Scott A Tomlins, Paul W Harms
Olfactory neuroblastomas (ONBs), also known as esthesioneuroblastomas, are malignant round-cell tumors that represent up to 5% of sinonasal malignancies. Despite their aggressive course, molecular studies of ONBs have been limited, and targeted therapies are lacking. To identify potential oncogenic drivers and targetable pathways in ONBs, we characterized 20 ONBs, including archived ONBs profiled by targeted, multiplexed PCR (mxPCR)-based DNA next-generation sequencing (NGS) of the coding sequence of over 400 cancer-relevant genes (n = 16), mxPCR-based RNA NGS of 108 target genes (n = 15), and 2 ONBs profiled by comprehensive hybrid-capture-based clinical grade NGS of >1,500 genes...
August 3, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28694837/metastatic-neoplasms-to-the-thyroid-diagnosed-by-fine-needle-aspiration-core-needle-biopsy-clinicopathologic-and-cytomorphologic-correlation
#14
Mobeen Rahman, Ashley Rae Okada, Kevin Guan, Pamela Tauchi-Nishi
BACKGROUND: Although thyroid fine-needle aspiration (FNA) and core needle biopsy (CNB) are commonly utilized modalities in the evaluation of thyroid nodules, metastatic tumors to the thyroid are only rarely encountered. We aspired to determine the incidence and primary origin of metastases to the thyroid at our institution and to examine their clinicopathologic and cytomorphologic features. MATERIALS AND METHODS: A search of our database was undertaken to review all thyroid FNA and/or CNB examined between January 2004 and December 2013...
2017: CytoJournal
https://www.readbyqxmd.com/read/28689974/endoscopic-surgery-for-sinonasal-tumors-the-transcribriform-approach
#15
T Radulesco, M Penicaud, P Dessi, J Michel
Over the past 10 to 20 years, endoscopic endonasal surgery has become for many teams the preferred treatment for sinonasal tumors. Technical advances in the field of surgical instrumentation (good visualization, hemostasis…) and the progress of imaging guidance (to avoid neurovascular complication) has made those procedures simpler and safer. Nevertheless, endonasal endoscopic procedures require a trained surgical team of ENT specialist and neurosurgeon. Endoscopic endonasal surgery has been reported to be feasible for all types of sinonasal tumors whether benign tumors such as inverted papillomas, or malignant tumors...
September 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28670560/-syndrome-of-inappropriate-antidiuretic-hormone-secretion-as-a-diagnostic-and-a-prognostic-indicator-in-olfactory-neuroblastoma
#16
K Devaraja, Kapil Sikka, Rajeev Kumar, Prem Sagar
No abstract text is available yet for this article.
July 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28661554/differentiation-of-olfactory-neuroblastomas-from-nasal-squamous-cell-carcinomas-using-mr-diffusion-kurtosis-imaging-and-dynamic-contrast-enhanced-mri
#17
Zebin Xiao, Zuohua Tang, Jinwei Qiang, Wen Qian, Yufeng Zhong, Rong Wang, Jie Wang, Lingjie Wu, Wenlin Tang
PURPOSE: To evaluate the use of magnetic resonance (MR) diffusion kurtosis imaging (DKI) and dynamic contrast-enhanced MR imaging (DCE-MRI) in the differentiation of olfactory neuroblastomas (ONBs) from squamous cell carcinomas (SCCs). MATERIALS AND METHODS: DKI and DCE-MRI were performed in 17 patients with ONBs and 23 patients with SCCs on a 3T MR scanner. Parameters derived from DKI and DCE-MRI were measured and compared between ONBs and SCCs using an independent samples t-test...
June 29, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28653386/long-term-control-of-olfactory-neuroblastoma-in-a-dog-treated-with-surgery-and-radiation-therapy
#18
E Gumpel, A S Moore, D J Simpson, K L Hoffmann, D P Taylor
BACKGROUND: Olfactory neuroblastoma is a rare malignancy of the nasal cavity in dogs that is thought to arise from specialised sensory neuroendocrine olfactory cells derived from the neural crest. CASE REPORT: An 8-year-old dog was presented for reclusiveness and pacing. On CT and MRI, a contract-enhancing mass was disclosed within the rostral fossa, extending caudally from the cribriform plate into the left nasal sinus. Surgical excision was performed and the diagnosis was histological grade III (Hyams grading scheme) olfactory neuroblastoma...
July 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28653384/in-this-issue-july-2017-rhdv-vaccine-protects-against-both-strains-of-virus-%C3%A2-%C3%A2-%C3%A2-olfactory-neuroblastoma-in-a-malamute-%C3%A2-%C3%A2-%C3%A2-coincidental-conditions-affecting-dysphagia-in-a-miniature-poodle-%C3%A2-%C3%A2-%C3%A2-support-for-storing-high-quality-bovine-colostrum-%C3%A2-%C3%A2-%C3%A2-sarcoptic
#19
EDITORIAL
https://www.readbyqxmd.com/read/28640941/phox2b-reliably-distinguishes-neuroblastoma-among-small-round-blue-cell-tumours
#20
Yin P Hung, John P Lee, Andrew M Bellizzi, Jason L Hornick
AIMS: Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The aim of this study was to validate the specificity and diagnostic utility of PHOX2B for peripheral neuroblastic tumours. METHODS AND RESULTS: We evaluated 240 cases (133 in whole-tissue sections; 107 in tissue microarrays), including 76 peripheral neuroblastic tumours (median age 2 years; including four adults) and 164 other tumours: 44 Wilms tumours; 20 Ewing sarcomas; 10 each of CIC-rearranged round cell sarcomas, poorly differentiated synovial sarcomas, lymphoblastic lymphomas, alveolar rhabdomyosarcomas, embryonal rhabdomyosarcomas, mesenchymal chondrosarcomas, Merkel cell carcinomas, olfactory neuroblastomas, and melanomas; and five each of NUT midline carcinomas and desmoplastic small round cell tumours...
June 22, 2017: Histopathology
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