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https://www.readbyqxmd.com/read/28324998/prediction-of-the-outcome-in-cardiac-arrest-patients-undergoing-hypothermia-using-eeg-wavelet-entropy
#1
Hana Moshirvaziri, Nima Ramezan-Arab, Shadnaz Asgari
Cardiac arrest (CA) is the leading cause of death in the United States. Induction of hypothermia has been found to improve the functional recovery of CA patients after resuscitation. However, there is no clear guideline for the clinicians yet to determine the prognosis of the CA when patients are treated with hypothermia. The present work aimed at the development of a prognostic marker for the CA patients undergoing hypothermia. A quantitative measure of the complexity of Electroencephalogram (EEG) signals, called wavelet sub-band entropy, was employed to predict the patients' outcomes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324978/influence-of-electrode-configuration-on-the-electric-field-distribution-during-transcutaneous-spinal-direct-current-stimulation-of-the-cervical-spine
#2
Sofia R Fernandes, Ricardo Salvador, Cornelia Wenger, Mamede A de Carvalho, Pedro C Miranda
Transcutaneous spinal direct current stimulation (tsDCS) is a recent technique with promising neuromodulatory effects on spinal neuronal circuitry. The main objective of the present study was to perform a finite element analysis of the electric field distribution in tsDCS in the cervical spine region, with varying electrode configurations and geometry. A computational model of a human trunk was generated with nine tissue meshes. Three electrode configurations were tested: A) rectangular saline-soaked sponge target and return electrodes placed over C3 and T3 spinous processes, respectively; B1) circular saline-soaked sponge target and return electrodes placed over C7 spinous process and right deltoid muscle, respectively; B2) same configuration as B1, considering circular shaped electrodes with sponge and rubber layers and a small circular connector on the top surface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324952/the-influence-of-the-pre-stimulation-neural-state-on-the-post-stimulation-neural-dynamics-via-distributed-microstimulation-of-the-hippocampus
#3
Mark J Connolly, Robert E Gross, Babak Mahmoudi
In this study we investigated how the neural state influences how the brain responds to electrical stimulation using a 16-channel microelectrode array with 8 stimulation and recording channels implanted in the rat hippocampus. In two experiments we identified the stimulation threshold at which the brain changes to an afterdischarge state. In one experiment a range of suprathreshold stimulations were applied, and in another the stimulation was not changed. The neural state was measured by the power spectral density prior to stimulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324946/characterization-of-motor-cortex-activity-of-the-lower-limb-region
#4
Fadi Mikhail, Karthikeyan Balasubramanian, Matthew D Best, Kazutaka Takahashi, Nicholas G Hatsopoulos
Understanding the functional properties of the motor cortex is a key step to developing effective neuroprosthetic and computer interfaces for amputees and patients with spinal cord injury. Most efforts have been directed towards studying the upper limb region of the motor cortex. Little has been done in the way of addressing lower limb motor cortical physiology. In this study, we implanted multiple microelectrode arrays along the central sulcus in the primary motor cortex of a macaque monkey. Using intracortical microstimulation, we identified neurons that evoked leg movements, either exclusively or mostly, and we studied their firing activity during a center-out arm movement task...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324890/regulation-of-itga3-by-the-dual-stranded-microrna-199-family-as-a-potential-prognostic-marker-in-bladder-cancer
#5
Takashi Sakaguchi, Hirofumi Yoshino, Masaya Yonemori, Kazutaka Miyamoto, Satoshi Sugita, Ryosuke Matsushita, Toshihiko Itesako, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
BACKGROUND: Based on the microRNA (miRNA) signature of bladder cancer (BC) by deep sequencing, we recently found that several double-stranded mature miRNAs derived from the same pre-miRNAs were sufficiently expressed and acted as tumour suppressors by regulating common target genes in BC. Our deep-sequencing signature of BC showed that all miR-199 family members (miR-199a-3p/-5p and miR-199b-3p/-5p) were also downregulated. We hypothesised that these miRNAs may function as tumour suppressors by regulating common target genes...
March 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28324829/interactive-effects-of-an-insecticide-and-a-fungicide-on-different-organism-groups-and-ecosystem-functioning-in-a-stream-detrital-food-web
#6
Mohab Dawoud, Mirco Bundschuh, Willem Goedkoop, Brendan G McKie
Freshwater ecosystems are often affected by cocktails of multiple pesticides targeting different organism groups. Prediction and evaluation of the ecosystem-level effects of these mixtures is complicated by the potential not only for interactions among the pesticides themselves, but also for the pesticides to alter biotic interactions across trophic levels. In a stream microcosm experiment, we investigated the effects of two pesticides targeting two organism groups (the insecticide lindane and fungicide azoxystrobin) on the functioning of a model stream detrital food web consisting of a detritivore (Ispoda: Asellus aquaticus) and microbes (an assemblage of fungal hyphomycetes) consuming leaf litter...
March 9, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28324779/frontocingulate-cerebral-blood-flow-and-cerebrovascular-reactivity-associated-with-antidepressant-response-in-late-life-depression
#7
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
BACKGROUND: Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical course. The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response. METHODS: 21 depressed elders completed cranial 3T MRI, including a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition on both room air and during a hypercapnia challenge...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28324707/chemical-structure-based-predictive-model-for-the-oxidation-of-trace-organic-contaminants-by-sulfate-radical
#8
Tiantian Ye, Zongsu Wei, Richard Spinney, Chong-Jian Tang, Shuang Luo, Ruiyang Xiao, Dionysios D Dionysiou
Second-order rate constants [Formula: see text] for the reaction of sulfate radical anion (SO4(•-)) with trace organic contaminants (TrOCs) are of scientific and practical importance for assessing their environmental fate and removal efficiency in water treatment systems. Here, we developed a chemical structure-based model for predicting [Formula: see text] using 32 molecular fragment descriptors, as this type of model provides a quick estimate at low computational cost. The model was constructed using the multiple linear regression (MLR) and artificial neural network (ANN) methods...
March 6, 2017: Water Research
https://www.readbyqxmd.com/read/28324696/online-neural-monitoring-of-statistical-learning
#9
Laura J Batterink, Ken A Paller
The extraction of patterns in the environment plays a critical role in many types of human learning, from motor skills to language acquisition. This process is known as statistical learning. Here we propose that statistical learning has two dissociable components: (1) perceptual binding of individual stimulus units into integrated composites and (2) storing those integrated representations for later use. Statistical learning is typically assessed using post-learning tasks, such that the two components are conflated...
February 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28324301/neuroimaging-in-epilepsy
#10
REVIEW
Erik H Middlebrooks, Lawrence Ver Hoef, Jerzy P Szaflarski
In recent years, the field of neuroimaging has undergone dramatic development. Specifically, of importance for clinicians and researchers managing patients with epilepsies, new methods of brain imaging in search of the seizure-producing abnormalities have been implemented, and older methods have undergone additional refinement. Methodology to predict seizure freedom and cognitive outcome has also rapidly progressed. In general, the image data processing methods are very different and more complicated than even a decade ago...
April 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28324258/optimizing-irrigation-and-nitrogen-for-wheat-through-empirical-modeling-under-semi-arid-environment
#11
Umer Saeed, Syed Aftab Wajid, Tasneem Khaliq, Zahir Ahmad Zahir
Nitrogen fertilizer availability to plants is strongly linked with water availability. Excessive or insufficient use of nitrogen can cause reduction in grain yield of wheat and environmental issues. The per capita per annum water availability in Pakistan has reduced to less than 1000 m(3) and is expected to reach 800 m(3) during 2025. Irrigating crops with 3 or more than 3 in. of depth without measuring volume of water is not a feasible option anymore. Water productivity and economic return of grain yield can be improved by efficient management of water and nitrogen fertilizer...
March 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28324176/bhlha9-regulates-apical-ectodermal-ridge-formation-during-limb-development
#12
Kensuke Kataoka, Takahide Matsushima, Yoshiaki Ito, Tempei Sato, Shigetoshi Yokoyama, Hiroshi Asahara
Split hand/foot malformation (SHFM) and SHFM combined with long-bone deficiency (SHFLD) are congenital dysgeneses of the limb. Although six different loci/mutations (SHFM1-SHFM6) have been found from studies on families with SHFM, the causes and associated pathogenic mechanisms for a large number of patients remain unidentified. On the basis of the identification of a duplicated gene region involving BHLHA9 in some affected families, BHLHA9 was identified as a novel SHFM/SHFLD-related gene. Although Bhlha9 is predicted to participate in limb development as a transcription factor, its precise function is unclear...
March 21, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28324171/risk-factors-for-delayed-gastric-emptying-after-esophagectomy
#13
Frank Benedix, Tobias Willems, Siegfried Kropf, Daniel Schubert, Patrick Stübs, Stephanie Wolff
PURPOSE: Delayed gastric emptying (DGE) is a common functional disorder after esophagectomy with gastric tube reconstruction. Little is known about risk factors that can predict this debilitating complication. METHODS: Patients who underwent elective esophagectomy from 2008 to 2016 in a single center were retrospectively reviewed. Diagnosis of DGE was based on clinical, radiological, and endoscopic findings. Uni- and multivariate analyses were performed to identify patient-, tumor-, and procedure-related factors that increase the risk of DGE...
March 21, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28324169/roles-of-centromedian-parafascicular-nuclei-of-thalamus-and-cholinergic-interneurons-in-the-dorsal-striatum-in-associative-learning-of-environmental-events
#14
REVIEW
Ko Yamanaka, Yukiko Hori, Takafumi Minamimoto, Hiroshi Yamada, Naoyuki Matsumoto, Kazuki Enomoto, Toshihiko Aosaki, Ann M Graybiel, Minoru Kimura
The thalamus provides a massive input to the striatum, but despite accumulating evidence, the functions of this system remain unclear. It is known, however, that the centromedian (CM) and parafascicular (Pf) nuclei of the thalamus can strongly influence particular striatal neuron subtypes, notably including the cholinergic interneurons of the striatum (CINs), key regulators of striatal function. Here, we highlight the thalamostriatal system through the CM-Pf to striatal CINs. We consider how, by virtue of the direct synaptic connections of the CM and PF, their neural activity contributes to the activity of CINs and striatal projection neurons (SPNs)...
March 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28324106/clinical-features-of-early-and-late-postoperative-hypothyroidism-after-lobectomy
#15
Suyeon Park, Min Ji Jeon, Eyun Song, Hye-Seon Oh, Mijin Kim, Hyemi Kwon, Tae Yong Kim, Suck Joon Hong, Young Kee Shong, Won Bae Kim, Tae-Yon Sung, Won Gu Kim
Context: Lobectomy is preferred in thyroid cancer to decrease surgical complications and avoid lifelong thyroid-hormone replacement. However, postoperative hypothyroidism, requiring thyroid-hormone replacement, may occur. Objective: We aimed to identify the incidence and risk factors of postoperative hypothyroidism to develop a surveillance strategy after lobectomy for papillary thyroid microcarcinoma (PTMC). Methods: This historical cohort study involved 335 PTMC patients treated by lobectomy...
January 11, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323985/utility-of-fdg-pet-imaging-for-risk-stratification-of-pancreatic-neuroendocrine-tumours-in-men-1
#16
E R Kornaczewski Jackson, O P Pointon, R Bohmer, J R Burgess
Context: Patients with Multiple Endocrine Neoplasia Type 1 (MEN 1) are at high risk of malignant pancreatic Neuroendocrine Tumours (pNETs). Structural imaging is typically used to screen for pNETs, but is suboptimal for stratifying malignant potential. Objective: To determine the utility of Fluorodeoxyglucose (18F) positron emission tomography/computed tomography (18F-FDG PET/CT) for predicting the malignant potential of pNETs in MEN 1. Design: Retrospective observational study...
March 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323946/outcome-of-non-functioning-pituitary-adenomas-that-regrow-after-primary-treatment-a-study-from-two-large-uk-centers
#17
Metaxia Tampourlou, Georgia Ntali, Shahzada Ahmed, Wiebke Arlt, John Ayuk, James V Byrne, Swarupsinh Chavda, Simon Cudlip, Neil Gittoes, Ashley Grossman, Rosalind Mitchell, Michael W O'Reilly, Alessandro Paluzzi, Andrew Toogood, John Ah Wass, Niki Karavitaki
Context: Despite the significant risk of regrowth of clinically non-functioning pituitary adenomas (CNFAs) after primary treatment, systematic data on the probability of further tumor progression and the effectiveness of management approaches are lacking. Objective: To assess the probability of further regrowth(s), predictive factors and outcomes of management approaches in patients with CNFA who have been diagnosed with adenoma regrowth after primary treatment...
March 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323801/predicting-acute-compartment-syndrome-pacs-the-role-of-continuous-monitoring
#18
Andrew H Schmidt, Michael J Bosse, Katherine P Frey, Robert V OʼToole, Daniel J Stinner, Daniel O Scharfstein, Vadim Zipunnikov, Ellen J MacKenzie
The diagnosis of acute compartment syndrome (ACS) is a common clinical challenge among patients who sustain high-energy orthopaedic trauma, largely because no validated criteria exist to reliably define the presence of the condition. In the absence of validated diagnostic standards, concern for the potential clinical and medicolegal impact of a missed compartment syndrome may result in the potential overuse of fasciotomy in "at-risk" patients. The goal of the Predicting Acute Compartment Syndrome Study was to develop a decision rule for predicting the likelihood of ACS that would reduce unnecessary fasciotomies while guarding against potentially missed ACS...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28323719/passive-leg-raising-for-assessment-of-volume-responsiveness-a-review
#19
Jaume Mesquida, Guillem Gruartmoner, Ricard Ferrer
PURPOSE OF REVIEW: To evaluate the existing evidence on the passive leg raising (PLR) test for fluid responsiveness prediction. RECENT FINDINGS: It has been well established that either insufficient or excessive fluid administration derives in worse outcomes in critically ill patients, highlighting that a more accurate assessment of fluid management is required. Accordingly, several cardiovascular indices have been tested to improve our ability to predict patients' response to fluid loading at the bedside, the so-called functional hemodynamic monitoring...
March 20, 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28323718/posterior-distraction-and-instrumentation-cannot-always-reduce-displaced-and-rotated-posterosuperior-fracture-fragments-in-thoracolumbar-burst-fracture
#20
Xiao-Bin Wang, Guo-Hua Lü, Jing Li, Bing Wang, Chang Lu, Kevin Phan
STUDY DESIGN: A retrospective clinical study. OBJECTIVE: To determine the imaging features that can be used to predict failure of reduction of a retropulsed fracture fragment by posterior ligamentotaxis in thoracolumbar burst fractures. SUMMARY OF BACKGROUND DATA: Posterior instrumentation and distraction with ligamentotaxis has been successfully used to shift retropulsed fragments anteriorly in thoracolumbar burst fractures. However, posterior longitudinal ligament rupture can lead to treatment failure...
April 2017: Clinical Spine Surgery
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