keyword
MENU ▼
Read by QxMD icon Read
search

functional prediction

keyword
https://www.readbyqxmd.com/read/29475175/guiding-exploration-in-conformational-feature-space-with-lipschitz-underestimation-for-ab-initio-protein-structure-prediction
#1
Xiaohu Hao, Guijun Zhang, Xiaogen Zhou
Computing conformations which are essential to associate structural and functional information with gene sequences, is challenging due to the high dimensionality and rugged energy surface of the protein conformational space. Consequently, the dimension of the protein conformational space should be reduced to a proper level, and an effective exploring algorithm should be proposed. In this paper, a plug-in method for guiding exploration in conformational feature space with Lipschitz underestimation (LUE) for ab-initio protein structure prediction is proposed...
February 6, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29475173/presence-of-artisanal-gold-mining-predicts-mercury-bioaccumulation-in-five-genera-of-bats-chiroptera
#2
Anjali Kumar, Timothy J Divoll, Priya M Ganguli, Florencia A Trama, Carl H Lamborg
Mercury, a toxic trace metal, has been used extensively as an inexpensive and readily available method of extracting gold from fine-grained sediment. Worldwide, artisanal mining is responsible for one third of all mercury released into the environment. By testing bat hair from museum specimens and field collected samples from areas both impacted and unimpacted by artisanal gold mining in Perú, we show monomethylmercury (MMHg) has increased in the last 100 years. MMHg concentrations were also greatest in the highest bat trophic level (insectivores), and in areas experiencing extractive artisanal mining...
February 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29475126/snp-rs403212791-in-exon-2-of-the-mtnr1a-gene-is-associated-with-reproductive-seasonality-in-the-rasa-aragonesa-sheep-breed
#3
J H Calvo, M Serrano, A Martinez-Royo, B Lahoz, P Sarto, A Ibañez-Deler, J Folch, J L Alabart
The aim of this study was to characterize and identify causative SNPs in the MTNR1A gene responsible for the reproductive seasonality traits in the Rasa aragonesa sheep breed. A total of 290 ewes (155, 84 and 51 mature, young and ewe lambs, respectively) from one flock were controlled from January to August. The following three reproductive seasonality traits were considered: the total days of anoestrus (TDA) and the progesterone cycling months (P4CM); both ovarian function seasonality traits based on blood progesterone levels; and the oestrus cycling months (OCM) based on oestrous detection, which indicate behavioural signs of oestrous...
February 12, 2018: Theriogenology
https://www.readbyqxmd.com/read/29475104/distress-and-sleep-quality-in-young-amphetamine-type-stimulant-users-with-an-affective-or-psychotic-illness
#4
Jacob J Crouse, Rico S C Lee, Django White, Ahmed A Moustafa, Ian B Hickie, Daniel F Hermens
Misuse of amphetamine-type stimulant (ATS) drugs may disrupt key neurodevelopmental processes in young people and confer protracted neurocognitive and psychopathological harm. ATS users with a co-occurring psychiatric illness are typically excluded from research, reducing generalisability of findings. Accordingly, we conducted a cross-sectional examination of key clinical, sleep, socio-occupational and neurocognitive measures in current, past and never users of ATS drugs who were accessing a youth mental health service (headspace) for affective- or psychotic-spectrum illnesses...
February 17, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29475076/from-percept-to-concept-in-the-ventral-temporal-lobes-graded-hemispheric-specialisation-based-on-stimulus-and-task
#5
Paul Hoffman, Matthew A Lambon Ralph
The left and right ventral anterior temporal lobes (vATL) have been implicated as key regions for the representation of conceptual knowledge. However, the nature and degree of hemispheric specialisation in their function is unclear. To address this issue, we investigated hemispheric specialisation in the ventral temporal lobes using a distortion-corrected spin-echo fMRI protocol that enhanced signal in vATL. We employed an orthogonal manipulation of stimulus (written words vs pictured objects) and task (naming vs recognition)...
February 2, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29475055/toxic-stress-history-and-hypothalamic-pituitary-adrenal-axis-function-in-a-social-stress-task-genetic-and-epigenetic-factors
#6
Hannah E Lapp, Sarah Ahmed, Celia L Moore, Richard G Hunter
Histories of early life stress (ELS) or social discrimination can reach levels of severity characterized as toxic to mental and physical health. Such toxic social stress during development has been linked to altered acute hypothalamic-pituitary-adrenal (HPA) response to social stress in adulthood. However, there are important individual differences in the size and direction of these effects. We explored developmental, genetic, epigenetic, and contextual sources of individual differences in the relationship between ELS, discrimination, and adult responses to acute social stress in a standard laboratory test...
February 21, 2018: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29474946/functional-results-and-patient-satisfaction-after-long-fusion-for-spinal-deformity-in-parkinson-s-disease
#7
C Scemama, G Mangone, R Bonaccorsi, H Pascal-Moussellard
BACKGROUND: Patients with Parkinson's disease often present abnormal posture or severe sagittal malalignment, causing significant disability. Surgical fusion is these cases shows high rates of complications, but may nevertheless provide functional benefit; however, this remains to be assessed. HYPOTHESIS: Long fusion for patients with Parkinson's disease and postural disorder could alleviate disability despite the high risk of complications. METHODS: We retrospectively reviewed 18 Parkinson patients treated by long fusion for spinal deformity...
February 20, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29474932/profiling-g-protein-coupled-receptors-of-fasciola-hepatica-identifies-orphan-rhodopsins-unique-to-phylum-platyhelminthes
#8
Paul McVeigh, Erin McCammick, Paul McCusker, Duncan Wells, Jane Hodgkinson, Steve Paterson, Angela Mousley, Nikki J Marks, Aaron G Maule
G protein-coupled receptors (GPCRs) are established drug targets. Despite their considerable appeal as targets for next-generation anthelmintics, poor understanding of their diversity and function in parasitic helminths has thwarted progress towards GPCR-targeted anti-parasite drugs. This study facilitates GPCR research in the liver fluke, Fasciola hepatica, by generating the first profile of GPCRs from the F. hepatica genome. Our dataset describes 147 high confidence GPCRs, representing the largest cohort of GPCRs, and the largest set of in silico ligand-receptor predictions, yet reported in any parasitic helminth...
February 5, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29474894/the-two-processes-underlying-the-testing-effect-evidence-from-event-related-potentials-erps
#9
Xiaonan L Liu, Deborah H Tan, Lynne M Reder
Theoretical explanations of the testing effect (why people learn better from a test than a re-study) have largely focused on either the benefit of attempting to retrieve the answer or on the benefit of re-encoding the queried information after a successful retrieval. While a less parsimonious account, prior neuroimaging evidence has led us to postulate that both of these processes contribute to the benefit of testing over re-study. To provide further empirical support for our position, we recorded ERPs while subjects attempted to recall the second word of a pair when cued with the first...
February 20, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29474884/cardiopulmonary-exercise-testing-in-hepato-biliary-pancreas-cancer-surgery-a-systematic-review-are-we-any-further-than-walking-up-a-flight-of-stairs
#10
REVIEW
R Kumar, G Garcea
INTRODUCTION: Cardiopulmonary exercise testing (CPET) is a reliable, reproducible and non-invasive measure of functional capacity. CPET has been increasingly used to assess pre-operative risk and stratify patients at risk of mortality and morbidity following surgery. CPET parameters that predict outcomes within liver and pancreas cancer surgery still remain to be defined. METHODS: A systematic review to assess CPET use in predicting post-operative outcomes in liver and pancreas cancer surgery was carried out using the following databases AMED, CINAHL, Cochrane Library, EMBASE, Google Scholar and PubMED...
February 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29474866/targeted-proteomic-analysis-of-cognitive-dysfunction-in-remitted-major-depressive-disorder-opportunities-of-multi-omics-approaches-towards-predictive-preventive-and-personalized-psychiatry
#11
K Oliver Schubert, David Stacey, Georgia Arentz, Scott R Clark, Tracy Air, Peter Hoffmann, Bernhard T Baune
In order to accelerate the understanding of pathophysiological mechanisms and clinical biomarker discovery and in psychiatry, approaches that integrate multiple -omics platforms are needed. We introduce a workflow that investigates a narrowly defined psychiatric phenotype, makes use of the potent and cost-effective discovery technology of gene expression microarrays, applies Weighted Gene Co-Expression Network Analysis (WGCNA) to better capture complex and polygenic traits, and finally explores gene expression findings on the proteomic level using targeted mass-spectrometry (MS) technologies...
February 20, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29474819/direct-evidence-for-high-affinity-blockade-of-na-v-1-6-channel-subtype-by-huwentoxin-iv-spider-peptide-using-multiscale-functional-approaches
#12
Tânia C Gonçalves, Rachid Boukaiba, Jordi Molgó, Muriel Amar, Michel Partiseti, Denis Servent, Evelyne Benoit
The Chinese bird spider huwentoxin-IV (HwTx-IV) is well-known to be a highly potent blocker of NaV 1.7 subtype of voltage-gated sodium (NaV ) channels, a genetically validated analgesic target, and thus promising as a potential lead molecule for the development of novel pain therapeutics. In the present study, the interaction between HwTx-IV and NaV 1.6 channel subtype was investigated using multiscale (from in vivo to individual cell) functional approaches. HwTx-IV was approximatively 2 times more efficient than tetrodotoxin (TTX) to inhibit the compound muscle action potential recorded from the mouse skeletal neuromuscular system in vivo, and 30 times more effective to inhibit nerve-evoked than directly-elicited muscle contractile force of isolated mouse hemidiaphragms...
February 20, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29474699/rationale-and-design-of-the-eacvi-afib-echo-europe-registry-for-assessing-relationships-of-echocardiographic-parameters-with-clinical-thrombo-embolic-and-bleeding-risk-profile-in-non-valvular-atrial-fibrillation
#13
Maurizio Galderisi, Erwan Donal, Julien Magne, Francesco Lo Iudice, Eustachio Agricola, Leyla Elif Sade, Matteo Cameli, Ehud Schwammenthal, Nuno Cardim, Bernard Cosyns, Andreas Hagendorff, Alexandar N Neskovic, Josè Luis Zamorano, Patrizio Lancellotti, Gilbert Habib, Thor Edvardsen, Bogdan A Popescu
The European Society of Cardiology (ESC) guidelines for management of atrial fibrillation (AF) recommend the use of CHA2DS2VASc risk score for assessment of thromboembolic (TE) risk, whereas the stratification of bleeding risk should be obtained by HAS-Bleed to balance the most appropriate anticoagulation (OAC) therapy. However, men with CHA2DS2VASc score = 1 and women with CHA2DS2VASc = 2, who are at intermediate TE risk, represent a grey zone where guidelines do not provide a definite OAC indication...
March 1, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29474698/antibodies-in-the-diagnosis-prognosis-and-prediction-of-psychotic-disorders
#14
Thomas A Pollak, Jonathan P Rogers, Robert G Nagele, Mark Peakman, James M Stone, Anthony S David, Philip McGuire
Blood-based biomarker discovery for psychotic disorders has yet to impact upon routine clinical practice. In physical disorders antibodies have established roles as diagnostic, prognostic and predictive (theranostic) biomarkers, particularly in disorders thought to have a substantial autoimmune or infective aetiology. Two approaches to antibody biomarker identification are distinguished: a "top-down" approach, in which antibodies to specific antigens are sought based on the known function of the antigen and its putative role in the disorder, and emerging "bottom-up" or "omics" approaches that are agnostic as to the significance of any one antigen, using high-throughput arrays to identify distinctive components of the antibody repertoire...
February 21, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29474602/prospective-cohort-studies-of-beta-trace-protein-and-mortality-in-haemodialysis-patients-and-patients-undergoing-coronary-angiography
#15
Dietmar Enko, Andreas Meinitzer, Hubert Scharnagl, Tatjana Stojakovic, Marcus E Kleber, Graciela E Delgado, Sieglinde Zelzer, Christiane Drechsler, Bernhard K Krämer, Christoph Wanner, Winfried März, Rainer P Woitas
Background: Beta-trace protein (BTP) is a low-molecular-weight glycoprotein, which may serve as an endogenous biomarker of kidney function and cardiovascular risk. Methods: We examined cardiovascular and all-cause mortality according to BTP concentrations in 2962 individuals referred for coronary angiography from the Ludwigshafen Risk and Cardiovascular Health study and in 907 patients with Type 2 diabetes mellitus undergoing haemodialysis from the German Diabetes and Dialysis (4D) study...
February 20, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29474517/cost-function-network-based-design-of-protein-protein-interactions-predicting-changes-in-binding-affinity
#16
Clément Viricel, Simon de Givry, Thomas Schiex, Sophie Barbe
Motivation: Accurate and economic methods to predict change in protein binding free energy upon mutation are imperative to accelerate the design of proteins for a wide range of applications. Free energy is defined by enthalpic and entropic contributions. Following the recent progresses of Artificial Intelligence-based algorithms for guaranteed NP-hard energy optimization and partition function computation, it becomes possible to quickly compute minimum energy conformations and to reliably estimate the entropic contribution of side-chains in the change of free energy of large protein interfaces...
February 20, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29474352/a-biophysical-model-of-dynamic-balancing-of-excitation-and-inhibition-in-fast-oscillatory-large-scale-networks
#17
Romesh G Abeysuriya, Jonathan Hadida, Stamatios N Sotiropoulos, Saad Jbabdi, Robert Becker, Benjamin A E Hunt, Matthew J Brookes, Mark W Woolrich
Over long timescales, neuronal dynamics can be robust to quite large perturbations, such as changes in white matter connectivity and grey matter structure through processes including learning, aging, development and certain disease processes. One possible explanation is that robust dynamics are facilitated by homeostatic mechanisms that can dynamically rebalance brain networks. In this study, we simulate a cortical brain network using the Wilson-Cowan neural mass model with conduction delays and noise, and use inhibitory synaptic plasticity (ISP) to dynamically achieve a spatially local balance between excitation and inhibition...
February 23, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29474266/recovery-from-schizophrenia-is-it-possible
#18
Antonio Vita, Stefano Barlati
PURPOSE OF REVIEW: Schizophrenia has a heterogeneous range of end states, from severe cases requiring repeated hospitalization to cases in which a single illness episode is followed by complete remission. The purpose of the present review is to examine recent literature on recovery in schizophrenia, focusing on the predictive factors and on the possibility to achieve it. RECENT FINDINGS: Roughly half of schizophrenia patients recovered or significantly improved over the long term, suggesting that functional remission is possible...
February 22, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29474218/an-evaluation-of-output-signal-to-noise-ratio-as-a-predictor-of-cochlear-implant-speech-intelligibility
#19
Greg D Watkins, Brett A Swanson, Gregg J Suaning
OBJECTIVES: Cochlear implant (CI) sound processing strategies are usually evaluated in clinical studies involving experienced implant recipients. Metrics which estimate the capacity to perceive speech for a given set of audio and processing conditions provide an alternative means to assess the effectiveness of processing strategies. The aim of this research was to assess the ability of the output signal to noise ratio (OSNR) to accurately predict speech perception. It was hypothesized that compared with the other metrics evaluated in this study (1) OSNR would have equivalent or better accuracy and (2) OSNR would be the most accurate in the presence of variable levels of speech presentation...
February 22, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29474058/directed-evolution-of-membrane-transport-using-synthetic-selections
#20
Anne Pihl Bali, Hans Jasper Genee, Morten Sommer
Understanding and engineering solute transporters is important for metabolic engineering and the development of therapeutics. However, limited available experimental data on membrane transporters makes sequence-function relationships complex to predict. Here we apply a ligand-responsive biosensor systems that enable selective growth of E. coli cells only if they functionally express an importer that is specific to the biosensor ligand. Using this system in a directed evolution framework, we successfully engineer the specificity of nicotinamide riboside transporters, PnuC, to accept thiamine as a substrate...
February 23, 2018: ACS Synthetic Biology
keyword
keyword
21321
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"