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https://www.readbyqxmd.com/read/29236333/effect-and-mechanism-of-lncrna-hotair-on-occurrence-and-development-of-gastric-cancer
#1
Xuan Feng, Suiping Huang
OBJECTIVE: In this study, we aimed at looking for the lncRNA abnormally expressed in gastric cancer (GC) tissues, and analyzing the association of its expression level with the clinicopathological feature and patient prognosis. The biological function of this lncRNA in occurrence and development of GC was studied in vivo and in vitro. The underlying molecular mechanism was further discussed. METHODS: We investigated the lncRNA expression level in GC tissues and normal gastric mucosa tissues by lncRNA chips analysis...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236256/integrated-analysis-of-mirna-and-mrna-expression-profiles-to-identify-mirna-targets
#2
Zhiming Li, Chi-Meng Tzeng
miRNAs are involved in various biological processes and different diseases through interacting with their target mRNAs. Therefore, deciphering miRNA targets is important for diagnostics and therapeutics. However, it is still complex and expensive to do large scale screening for miRNA alterations and identify their downstream miRNA targets. Recently, integrating analysis of miRNA expression profiles and mRNA expression levels has been used to successfully identify the most prominent interactions. Here, we present a protocol that combines both expression data and computational prediction to refine the microarray result for identifying the miRNA targets...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29236239/abdominal-aorta-and-pelvic-artery-calcifications-on-plain-radiographs-may-predict-mortality-in-chronic-kidney-disease-hemodialysis-and-renal-transplantation
#3
Sinee Disthabanchong, Kotcharat Vipattawat, Bunyong Phakdeekitcharoen, Chagriya Kitiyakara, Vasant Sumethkul
PURPOSE: Vascular calcification is common in chronic kidney disease (CKD) and predicts poor patient outcomes. While computed tomography is the gold standard for evaluation of vascular calcification, plain radiograph offers a simpler and less costly alternative. The calcification of abdominal aorta, iliac and femoral arteries has been evaluated by plain radiograph, but the data on their outcome predictabilities are still limited. The present study investigated the role of abdominal aortic calcification (AAC) and pelvic arterial calcification (PAC) in predicting overall morality in non-dialysis CKD stages 2-5 (CKD 2-5), maintenance hemodialysis (HD) and long-term kidney transplant (KT) patients...
December 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29236185/genome-wide-identification-and-cadmium-induced-expression-profiling-of-sulfate-transporter-sultr-genes-in-sorghum-sorghum-bicolor-l
#4
M Aydın Akbudak, Ertugrul Filiz, Kubra Kontbay
Sulfur is an essential element for all living organisms. Plants can convert inorganic sulfur into organic sulfur compounds by complex enzymatic steps. In this study, we conducted a genome-wide analysis of sulfate transporter genes (SULTRs) in the sorghum (Sorghum bicolor) genome and examined expression profiles of SbSULTR genes under 200 µM cadmium (Cd) exposure. As a result of sorghum genome analysis, 11 SULTR genes were identified, including SbSULTR1;1, SbSULTR1;2, SbSULTR1;3, SbSULTR2;1, SbSULTR2;2, SbSULTR3;1, SbSULTR3;2, SbSULTR3;3, SbSULTR3;4, SbSULTR3;5, and SbSULTR4...
December 13, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29236161/genetic-analysis-of-adults-heterozygous-for-alpl-mutations
#5
Agnès Taillandier, Christelle Domingues, Annika Dufour, Françoise Debiais, Pascal Guggenbuhl, Christian Roux, Catherine Cormier, Bernard Cortet, Valérie Porquet-Bordes, Fabienne Coury, David Geneviève, Jean Chiesa, Thierry Colin, Elaine Fletcher, Agnès Guichet, Rose-Marie Javier, Michel Laroche, Michael Laurent, Ekkehart Lausch, Bruno LeHeup, Cédric Lukas, Georg Schwabe, Ineke van der Burgt, Christine Muti, Brigitte Simon-Bouy, Etienne Mornet
Hypophosphatasia (HPP) is a rare inherited metabolic bone disease due to a deficiency of the tissue nonspecific alkaline phosphatase isoenzyme (TNSALP) encoded by the ALPL gene. Patients have consistently low serum alkaline phosphatase (AP), so that this parameter is a good hallmark of the disease. Adult HPP is heterogeneous, and some patients present only mild nonpathognomonic symptoms which are also common in the general population such as joint pain, osteomalacia and osteopenia, chondrocalcinosis, arthropathy and musculoskeletal pain...
December 13, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29235996/research-on-a-soft-measurement-model-of-sewage-treatment-based-on-a-case-based-reasoning-approach
#6
Jiayan Zhang, Cuicui Du, Xugang Feng
In this paper, the measurement of biochemical oxygen demand (BOD) in a wastewater treatment process is analyzed and an intelligent integrated prediction method based on case-based reasoning (CBR) is proposed in order to overcome difficulties. Due to the fact that there are many factors that influence the accuracy of the prediction model, the radial basis function, which is a neural network with a 3 layer feedforward network, is employed to reduce the dimension of input values. Under these circumstances, a back propagation neural network combining with a nearest neighbor retrieval strategy is adopted to match case...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235987/gene-free-methodology-for-cell-fate-dynamics-during-development
#7
Francis Corson, Eric D Siggia
Models of cell function that assign a variable to each gene frequently lead to systems of equations with many parameters whose behavior is obscure. Geometric models reduce dynamics to intuitive pictorial elements that provide compact representations for sparse in-vivo data and transparent descriptions of developmental transitions. To illustrate, a geometric model fit to vulval development in C. elegans, implies a phase diagram where cell-fate choices are displayed in a plane defined by EGF and Notch signaling levels...
December 13, 2017: ELife
https://www.readbyqxmd.com/read/29235863/entrance-effects-induced-rectified-ionic-transport-in-a-nanopore-channel
#8
Yu Ma, Jinxiu Guo, Laibing Jia, Yanbo Xie
The nanofluidic diode, as one of the emerging nanofluidic logic devices, has been used in many fields such as biosensors, energy harvesting and so on. However, the entrance effects of the nanofluidic ionic conductance were less discussed, which can be a crucial factor for the ionic conduction. Here we calculate the ionic conductance as a function of the length-to-pore ratio (L/r), which has a clear boundary between nanopore (surface dominated) and nanochannel (geometry dominated) electrically in diluted salt solution...
December 13, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29235470/upregulation-of-b7-h4-promotes-tumor-progression-of-intrahepatic-cholangiocarcinoma
#9
Nan Xie, Jia-Bin Cai, Lu Zhang, Peng-Fei Zhang, Ying-Hao Shen, Xuan Yang, Jia-Cheng Lu, Dong-Mei Gao, Qiang Kang, Li-Xin Liu, Chi Zhang, Xiao-Yong Huang, Hao Zou, Xin-Yu Zhang, Zheng-Ji Song, Hai-Xiang Sun, Bi-Mang Fu, Ai-Wu Ke, Guo-Ming Shi
Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression. However, its expression and role in intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, B7-H4 expression in ICC and peritumoral tissues was determined at the level of mRNA and protein, and its bioactivity in ICC cells was studied after modification of B7-H4 expression. Then, the mechanism related to tumor progression induced by B7-H4 expression in ICC cells was explored...
December 13, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29235352/systems-approaches-to-understanding-and-designing-allosteric-proteins
#10
Srivatsan Raman
The study of allostery has a central place in biology due to the myriad roles of allosteric proteins in cellular function. As technologies to probe spatiotemporal resolution of biomolecules have become increasingly sophisticated, so has our understanding of the diverse structural and molecular mechanisms of allosteric proteins. Studies have shown that allosteric signal is transmitted a through a network of residue-residue interactions connecting distal sites on a protein. Linking structural and dynamical changes to the functional role of individual residues will give a more complete molecular view of allostery...
December 13, 2017: Biochemistry
https://www.readbyqxmd.com/read/29235291/-rapid-determination-of-nine-components-in-the-first-extraction-process-of-xingnaojing-injection-by-using-ultraviolet-spectroscopy
#11
Kai-Yi Huang, Dan-Ni Wei, Jin-Yang Fang, Xi-Yuan Li, Bin-Jun Yan
In this study, an analytical method based on ultraviolet spectroscopy was established for the rapid determination of nine components including isophorone, 4-methylene-isophorone, curcumenone, curcumenol, curdione, curzerenone, furanodienone, curcumol and germacrone in the first extraction process of Xingnaojing injection. 166 distillate samples of Gardeniae Fructus and Radix Curcumae were collected in the first extraction process of Xingnaojing injection. The ultraviolet spectra of these samples were collected, and the contents of the nine components in these samples were determined by high performance liquid chromatography...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29235260/functional-polymorphisms-of-innate-immunity-receptors-are-not-risk-factors-for-the-non-sbp-type-bacterial-infections-in-cirrhosis
#12
Tamas Dinya, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, Boglárka Balogh, David Tornai, Peter Antal-Szalmas, Andrea Sumegi, Hajnalka Andrikovics, Andras Bors, Attila Tordai, Maria Papp
BACKGROUND&AIMS: Pattern recognition receptors (PRRs) have a key role in the innate host defense. Functional polymorphisms of various PRRs have been established to contribute to an increased susceptibility to spontaneous bacterial peritonitis (SBP). Their role in the development of cirrhosis-associated bacterial infections (BI), beyond SBP or progressive disease course related to pathological bacterial translocation (BT) remains unknown. METHODS: 349 patients with cirrhosis were genotyped for common NOD2 (R702W, G908R and L1007PfsinsC), TLR2 (-16934T>A), and TLR4 (D299G) variants...
December 13, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29235231/influencing-factors-in-quantitative-measurement-using-activated-platelet-levels-and-platelet-activating-capacity-for-the-assessment-of-thrombosis-in-pre-metabolic-syndrome-and-type-2-diabetes-mellitus
#13
Kozue Okano, Kazuki Shitamoto, Minako Araki, Chie Kawamoto, Reo Kawano, Hiroshi Nogaki
Activated platelet levels and platelet-activating capacity are well recognized as useful index parameters for the physiological and pharmacological prediction of thrombotic events. Recently, quantitative measurements for platelet functions using a flow cytometer have been increasing gradually. However, the relation of physiological factors, such as sex, aging, and laboratory tests, to platelet functions has not been well documented. We conducted a blood analysis of people with normal/pre-metabolic syndrome and patients with type 2 diabetes mellitus to clarify the pathological factors...
December 12, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29235146/development-of-metal-active-site-and-zinccluster-tool-to-predictactive-site-pockets
#14
M Ajitha, K Sundar, S Arul Mugilan, S Arumugam
The advent of whole genome sequencing leads to increasing number of proteins with known amino acid sequences. Despite many efforts, the number of proteins with resolved three dimensional structures is still low. One of the challenging tasks the structural biologists face is the prediction of the interaction of metal ion with any protein for which the structure is unknown. Based on the information available in PDB, a site (METALACTIVE INTERACTION) has been generated which displays information for significant high preferential and low-preferential combination of endogenous ligands for 49 metal ions...
December 13, 2017: Proteins
https://www.readbyqxmd.com/read/29235143/allostatic-load-but-not-medical-burden-predicts-memory-performance-in-late-life-bipolar-disorder
#15
REVIEW
Sophie R Vaccarino, Tarek K Rajji, Ariel G Gildengers, Sarah E S Waters, Meryl A Butters, Mahesh Menon, Daniel M Blumberger, Aristotle N Voineskos, Dielle Miranda, Benoit H Mulsant
OBJECTIVE: Older patients with bipolar disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes, and comorbidities increase the body's allostatic load. We assessed the extent to which allostatic load vs more traditional measures of medical burden account for the heterogeneity in cognition in this population. METHODS: Thirty-five older euthymic patients with BD and 30 age-equated, gender-equated, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load...
December 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29235142/assessment-of-data-assisted-prediction-by-inclusion-of-crosslinking-mass-spectrometry-and-small-angle-x-ray-scattering-data-in-the-12th-critical-assessment-of-protein-structure-prediction-experiment
#16
Giorgio E Tamò, Luciano A Abriata, Giulia Fonti, Matteo Dal Peraro
Integrative modeling approaches attempt to combine experiments and computation to derive structure-function relationships in complex molecular assemblies. Despite their importance for the advancement of life sciences, benchmarking of existing methodologies is rather poor. The 12th round of the Critical Assessment of protein Structure Prediction (CASP) offered a unique niche to benchmark data and methods from two kinds of experiments often used in integrative modeling, namely residue-residue contacts obtained through crosslinking/mass-spectrometry (CLMS), and small-angle X-ray scattering (SAXS) experiments...
December 13, 2017: Proteins
https://www.readbyqxmd.com/read/29235028/artificial-intelligence-and-regression-analysis-for-cd-ii-ion-biosorption-from-aqueous-solution-by-gossypium-barbadense-waste
#17
Manal Fawzy, Mahmoud Nasr, Heba Nagy, Shacker Helmi
In this study, batch biosorption experiments were conducted to determine the removal efficiency of Cd(II) ion from aqueous solutions by Gossypium barbadense waste. The biosorbent was characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) connected with energy dispersive X-ray (EDX). The sorption mechanism was described by complexation/chelation of Cd2+ with the functional groups of O-H, C=O, -COO-, and C-O, as well as, cation-exchange with Mg2+ and K+. At initial Cd(II) ion concentration (C o), 50 mg/L, the adsorption equilibrium of 89...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29234997/learning-epistatic-interactions-from-sequence-activity-data-to-predict-enantioselectivity
#18
Julian Zaugg, Yosephine Gumulya, Alpeshkumar K Malde, Mikael Bodén
Enzymes with a high selectivity are desirable for improving economics of chemical synthesis of enantiopure compounds. To improve enzyme selectivity mutations are often introduced near the catalytic active site. In this compact environment epistatic interactions between residues, where contributions to selectivity are non-additive, play a significant role in determining the degree of selectivity. Using support vector machine regression models we map mutations to the experimentally characterised enantioselectivities for a set of 136 variants of the epoxide hydrolase from the fungus Aspergillus niger (AnEH)...
December 12, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/29234939/the-role-of-preoperative-high-resolution-manometry-in-predicting-dysphagia-after-laparoscopic-nissen-fundoplication
#19
Sonam Kapadia, Turner Osler, Allen Lee, Edward Borrazzo
BACKGROUND: Laparoscopic fundoplication is an accepted surgical management of refractory gastro-esophageal reflux disease (GERD). The use of high resolution esophageal manometry (HRM) in preoperative evaluation is often applied to determine the degree of fundoplication to optimize reflux control while minimizing adverse sequela of postoperative dysphagia. OBJECTIVE: Assess the role of preoperative HRM in predicting surgical outcomes, specifically risk assessment of postoperative dysphagia and quality of life, among patients receiving laparoscopic Nissen fundoplication for GERD with immediate postoperative (< 4 weeks clinic), short-term (3-month clinic), and long-term (34 ± 10...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29234916/do-acute-effects-of-exercise-on-vascular-function-predict-adaptation-to-training
#20
Ellen A Dawson, N Timothy Cable, Daniel J Green, Dick H J Thijssen
PURPOSE: No previous study has explored the importance of exercise-induced changes in vascular function to prolonged adaptations. Therefore, the purpose was to explore the within-subject relationship between the acute post-exercise change in brachial artery endothelial function (flow-mediated dilation, FMD) and the change in resting FMD after a 2-week exercise training in healthy volunteers. METHODS: Twenty one healthy, young men (24 ± 5 years) underwent assessment of brachial artery FMD using high-resolution ultrasound before and after 30-min of moderate-intensity cycle exercise (80% maximal heart rate)...
December 12, 2017: European Journal of Applied Physiology
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