keyword
https://read.qxmd.com/read/38523196/modeling-time-varying-phytoplankton-subsidy-reveals-at-risk-species-in-a-chilean-intertidal-ecosystem
#21
JOURNAL ARTICLE
Casey Duckwall, John L Largier, Evie A Wieters, Fernanda S Valdovinos
The allometric trophic network (ATN) framework for modeling population dynamics has provided numerous insights into ecosystem functioning in recent years. Herein we extend ATN modeling of the intertidal ecosystem off central Chile to include empirical data on pelagic chlorophyll-a concentration. This intertidal community requires subsidy of primary productivity to support its rich ecosystem. Previous work models this subsidy using a constant rate of phytoplankton input to the system. However, data shows pelagic subsidies exhibit highly variable, pulse-like behavior...
March 24, 2024: Scientific Reports
https://read.qxmd.com/read/38515396/determination-of-in-vitro-and-in-vivo-effects-of-taxifolin-and-epirubicin-on-epithelial-mesenchymal-transition-in-mouse-breast-cancer-cells
#22
JOURNAL ARTICLE
Muhammet Ocak, Duygu Deniz Usta, Gokce Nur Arik Erol, Gulnur Take Kaplanoglu, Ece Konac, Atiye Seda Yar Saglam
Background: One of the most significant characteristics of cancer is epithelial-mesenchymal transition and research on the relationship between phenolic compounds and anticancer medications and epithelial-mesenchymal transition is widespread. Methods: In order to investigate the potential effects of Taxifolin on enhancing the effectiveness of Epirubicin in treating breast cancer, specifically in 4T1 cells and an allograft BALB/c model, the effects of Taxifolin and Epirubicin, both individually and in combination, were examined...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38515113/the-genetic-diversity-of-oncomelania-hupensis-robertsoni-intermediate-hosts-of-schistosoma-japonicum-in-hilly-regions-of-china-using-microsatellite-markers
#23
JOURNAL ARTICLE
Jing Song, Hongqiong Wang, Shizhu Li, Chunhong Du, Peijun Qian, Wenya Wang, Meifen Shen, Zongya Zhang, Jihua Zhou, Yun Zhang, Chunying Li, Yuwan Hao, Yi Dong
BACKGROUND: The elimination of schistosomiasis remains a challenging task, with current measures primarily focused on the monitoring and control of Oncomelania hupensis (O. hupensis) snail, the sole intermediate host of Schistosome japonicum. Given the emerging, re-emerging, and persistent habitats of snails, understanding their genetic diversity might be essential for their successful monitoring and control. The aims of this study were to analyze the genetic diversity of Oncomelania hupensis robertsoni (O...
March 21, 2024: Parasites & Vectors
https://read.qxmd.com/read/38513918/snail-transcription-factors-characteristics-regulation-and-molecular-targets-relevant-in-vital-cellular-activities-of-ovarian-cancer-cells
#24
REVIEW
Michal Kielbik, Izabela Szulc-Kielbik, Magdalena Klink
Snail transcription factors play essential roles in embryonic development and participate in many physiological processes. However, these genes have been implicated in the development and progression of various types of cancer. In epithelial ovarian cancer, high expression of these transcription factors is usually associated with the acquisition of a more aggressive phenotype and thus, considered to be a poor prognostic factor. Numerous molecular signals create a complex network of signaling pathways regulating the expression and stability of Snails, which in turn control genes involved in vital cellular functions of ovarian cancer cells, such as invasion, survival, proliferation and chemoresistance...
March 19, 2024: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/38512937/the-biocontrol-nematode-phasmarhabditis-hermaphrodita-infects-and-increases-mortality-of-monadenia-fidelis-a-non-target-terrestrial-gastropod-species-endemic-to-the-pacific-northwest-of-north-america-in-laboratory-conditions
#25
JOURNAL ARTICLE
Dee Denver, Dana K Howe, Andrew J Colton, Casey H Richart, Rory J Mc Donnell
Inundative biological control (biocontrol) efforts in pest management lead to the mass distribution of commercialized biocontrol agents. Many 'biocontrol gone awry' incidents have resulted in disastrous biodiversity impacts, leading to increased scrutiny of biocontrol efforts. The nematode Phasmarhabditis hermaphrodita is sold as a biocontrol agent on three continents and targets pest gastropods such as Deroceras reticulatum, the Grey Field Slug; P. hermaphrodita is not presently approved for use in the United States...
2024: PloS One
https://read.qxmd.com/read/38512035/-yes-associated-protein-yap-promotes-invasion-and-migration-of-cutaneous-squamous-cell-carcinoma-cells-by-activating-the-pi3k-akt-pathway
#26
JOURNAL ARTICLE
Zhenling Li, Fan Yang, Xuemei Jin, Xueyan Wang, Taiqin Chen, Chunji Quan
Objective To investigate the expression of Yes-associated protein (YAP) in cutaneous squamous cell carcinoma (cSCC) and its effects on invasion and migration. Methods Immunohistochemical staining was used to detect the expression of YAP in cSCC, Bowen disease (BD), and adjacent normal tissues, and analyzed the correlation between YAP expression and clinicopathological characteristics of cSCC. A stable cell line in A431 cells with YAP gene silencing was established through lentiviral infection. Tetramethylrhodamine isothiocyanate (TRITC)-phalloidin staining was performed to analyze the distribution and number of microfilaments in A431 cells...
March 2024: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://read.qxmd.com/read/38511855/discovery-of-the-tryptanthrin-derived-indoloquinazoline-as-an-anti-breast-cancer-agent-via-erk-jnk-activation
#27
JOURNAL ARTICLE
Chih-Shiang Chang, Li-Yuan Bai, Chang-Fang Chiu, Jing-Lan Hu, Jing-Ru Weng
Tryptanthrin, an alkaloid applied in traditional Chinese medicine, exhibits a variety of pharmacological activities. This study aimed to investigate the anti-tumor activity of the tryptanthrin derivative (8-cyanoindolo[2,1-b]quinazoline-6,12-dione [CIQ]) in breast cancer cells. In both MDA-MB-231 and MCF-7 breast cancer cells, CIQ inhibited cell viability and promoted caspase-dependent apoptosis. At the concentration- and time-dependent ways, CIQ increased the levels of p-ERK, p-JNK, and p-p38 in breast cancer cells...
March 21, 2024: Environmental Toxicology
https://read.qxmd.com/read/38509855/activities-of-pumpkin-seed-oil-against-biomphalaria-alexandrina-snails-and-the-infective-stages-of-schistosoma-mansoni-with-special-emphasis-on-genotoxic-and-histopathological-alterations
#28
JOURNAL ARTICLE
S E Mohammed, H S Mossalem, R M Gad El-Karim, A T Morsy, A M Ammar
Schistosomiasis is a serious health issue in tropical regions, and natural compounds have gained popularity in medical science. This study investigated the potential effects of pumpkin seed oil (PSO) on Biomphalaria [B.] alexandrina snails (Ehrenberg, 1831), Schistosoma [S.] mansoni (Sambon, 1907) miracidium, and cercariae. The chemical composition of PSO was determined using gas chromatography/mass spectrometry. A bioassay was performed to evaluate the effects of PSO on snails, miracidia, and cercariae. The results showed no significant mortality of B...
March 21, 2024: Journal of Helminthology
https://read.qxmd.com/read/38509853/nematodes-associated-with-terrestrial-gastropod-molluscs-in-belgium-and-additional-characterisation-of-pellioditis-californica-and-p-hermaphrodita
#29
JOURNAL ARTICLE
M A Cortes, W Bert, M Couvreur, D De Waele, P R Singh
A survey for slug- and snail-associated nematodes was conducted in forests, parks, botanical gardens, and nature reserves at 13 localities in Belgium to uncover more diversity of gastropod mollusc-associated nematodes and to characterise Pellioditis populations found in the country. A total of 319 slugs and snails belonging to nine species were examined. Arion vulgaris was the most commonly found mollusc species in this study (eight locations), and 19.4% of the examined mollusc specimens were found infected by nematodes...
March 21, 2024: Journal of Helminthology
https://read.qxmd.com/read/38509084/universal-control-of-a-bosonic-mode-via-drive-activated-native-cubic-interactions
#30
JOURNAL ARTICLE
Axel M Eriksson, Théo Sépulcre, Mikael Kervinen, Timo Hillmann, Marina Kudra, Simon Dupouy, Yong Lu, Maryam Khanahmadi, Jiaying Yang, Claudia Castillo-Moreno, Per Delsing, Simone Gasparinetti
Linear bosonic modes offer a hardware-efficient alternative for quantum information processing but require access to some nonlinearity for universal control. The lack of nonlinearity in photonics has led to encoded measurement-based quantum computing, which relies on linear operations but requires access to resourceful ('nonlinear') quantum states, such as cubic phase states. In contrast, superconducting microwave circuits offer engineerable nonlinearities but suffer from static Kerr nonlinearity. Here, we demonstrate universal control of a bosonic mode composed of a superconducting nonlinear asymmetric inductive element (SNAIL) resonator, enabled by native nonlinearities in the SNAIL element...
March 21, 2024: Nature Communications
https://read.qxmd.com/read/38508311/structural-analysis-of-a-u-superfamily-conotoxin-containing-a-mini-granulin-fold-insights-into-key-features-that-distinguish-between-the-ick-and-granulin-folds
#31
JOURNAL ARTICLE
Tiziano Raffaelli, David T Wilson, Sebastien Dutertre, Julien Giribaldi, Irina Vetter, Samuel D Robinson, Ashvriya Thapa, Antin Widi, Alex Loukas, Norelle L Daly
We are entering an exciting time in structural biology where artificial intelligence can be used to predict protein structures with greater accuracy than ever before. Extending this level of accuracy to the predictions of disulfide-rich peptide structures is likely to be more challenging, at least in the short term, given the tight packing of cysteine residues and the numerous ways that the disulfide bonds can potentially be linked. It has been previously shown in many cases that several disulfide bond connectivities can be accommodated by a single set of NMR-derived structural data without significant violations...
March 18, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38505602/fsh-induces-emt-in-ovarian-cancer-via-alkbh5-regulated-snail-m6a-demethylation
#32
JOURNAL ARTICLE
Xingyan Xu, Xuefen Zhuang, Haowei Yu, Ping Li, Xiaosa Li, Huiping Lin, Jian-Peng Teoh, Yiwen Chen, Yuanlan Yang, Yang Cheng, Weiyu Chen, Xiaodong Fu
Background: The therapeutic benefits of targeting follicle-stimulating hormone (FSH) receptor in treatment of ovarian cancer are significant, whereas the role of FSH in ovarian cancer progresses and the underlying mechanism remains to be developed. Methods: Tissue microarray of human ovarian cancer, tumor xenograft mouse model, and in vitro cell culture were used to investigate the role of FSH in ovarian carcinogenesis. siRNA, lentivirus and inhibitors were used to trigger the inactivation of genes, and plasmids were used to increase transcription of genes...
2024: Theranostics
https://read.qxmd.com/read/38503384/exploiting-transcription-factors-to-target-emt-and-cancer-stem-cells-for-tumor-modulation-and-therapy
#33
REVIEW
Abdul Q Khan, Adria Hasan, Snober S Mir, Khalid Rashid, Shahab Uddin, Martin Stienhoff
Transcription factors (TFs) are essential in controlling gene regulatory networks that determine cellular fate during embryogenesis and tumor development. TFs are the major players in promoting cancer stemness by regulating the function of cancer stem cells (CSCs). Understanding how TFs interact with their downstream targets for determining cell fate during embryogenesis and tumor development is a critical area of research. CSCs are increasingly recognized for their significance in tumorigenesis and patient prognosis, as they play a significant role in cancer initiation, progression, metastasis, and treatment resistance...
March 17, 2024: Seminars in Cancer Biology
https://read.qxmd.com/read/38503263/pak1-promotes-inflammation-induced-by-sepsis-through-the-snail-cxcl2-signaling-pathway
#34
JOURNAL ARTICLE
Miaomiao Chen, Liuhua Pan, Deyuan Chen, Yueming Wu, Jianping Ye, Ke Li, Ning Zhang, Junlong Xu
Sepsis is a severe syndrome characterized by organ dysfunction, resulting from a systemic imbalance in response to infection. PAK1 plays a critical role in various diseases. The present study aimed to explore and delineate the mechanism of PAK1 in inflammation induced by sepsis. Bioinformatics analysis was performed to assess PAK1, snail, and CXCL2 expression in the whole blood of septic patients and the pathways enriched with PAK1. To simulate the sepsis model, THP-1 cells were stimulated with lipopolysaccharide...
March 19, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38503108/dibutyl-phthalate-dbp-promotes-epithelial-mesenchymal-transition-emt-to-aggravate-liver-fibrosis-into-cirrhosis-and-portal-hypertension-pht-via-ros-tgf-%C3%AE-1-snail-1-signalling-pathway-in-adult-rats
#35
JOURNAL ARTICLE
Min Chen, Guang-Bo Wu, Shan Hua, Lei Zheng, Qiang Fan, Meng Luo
OBJECTIVE: The primary objective of this study was to investigate the toxicological impact of Dibutyl phthalate (DBP) on the process of liver fibrosis transitioning into cirrhosis and the subsequent development of portal hypertension (PHT) through the mechanism of epithelial-mesenchymal transition (EMT) mediated by the ROS/TGF-β/Snail-1 signaling pathway. METHOD: Carbon tetrachloride (CCl4 ) (1 mg/kg) was introduced in adult rats by oral feeding in CCl4 and CCl4 +DBP groups twice a week for 8 weeks, and twice for another 8 week in CCl4 group...
March 18, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38502474/differentiation-of-bulinus-senegalensis-and-bulinus-forskalii-snails-in-west-africa-using-morphometric-analysis
#36
JOURNAL ARTICLE
Peter S Andrus, Ebrima Joof, Christopher M Wade
PURPOSE: Accurate identification of medically important intermediate host and vector species is crucial for understanding disease transmission and control. Identifying Bulinus snails which act as intermediate host species for the transmission of schistosomiasis is typically undertaken using conchological and genital morphology as well as molecular methods. METHODS: Here, a landmark-based morphometric analysis of shell morphology was undertaken to determine its utility to distinguish the closely related and morphologically similar sister species Bulinus senegalensis and Bulinus forskalii...
March 19, 2024: Acta Parasitologica
https://read.qxmd.com/read/38501006/ursolic-acid-inhibits-glioblastoma-through-suppressing-tgf%C3%AE-mediated-epithelial-mesenchymal-transition-emt-and-angiogenesis
#37
JOURNAL ARTICLE
Bo Hei, Ru-En Liu, Meihua Li
Found in many fruits and plants, Ursolic acid (UA), a pentacyclic triterpene that occurs naturally, is recognized for its anti-cancer effects, especially in combating glioblastoma. However, the intricate molecular mechanisms underpinning its anti-tumor actions are still not fully understood, despite the recognition of these effects. By examining the functions of epithelial-mesenchymal transition (EMT) and angiogenesis, crucial for glioblastoma progression, and their regulation through Transforming Growth Factor Beta (TGFβ) - a key marker for glioblastoma, our research aims to fill this knowledge gap...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38500983/digenean-infections-in-snails-cercariae-stage-in-can-gio-mangrove-biosphere-reserve-ho-chi-minh-city-vietnam
#38
JOURNAL ARTICLE
Pham Cu Thien, Thi Duong Nguyen
Foodborne zoonotic trematodiasis is a public health problem in many countries. A study on digenean larvae (cercariae stage) obtained from snails in all ten main small canals and two rice fields was carried out in Can Gio Mangrove Biosphere Reserve, Ho Chi Minh city, Vietnam to identify the snail composition and digenean prevalence in snails. The snails were sampled in the dry season (January 2022) and the wet season (June 2022). In the ten canals, 23 snail species belonging to 16 genera, 10 families from the samplings were found; however, there were no cercariae in these 23 snail species...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38498490/the-who-atlas-for-female-genital-schistosomiasis-co-design-of-a-practicable-diagnostic-guide-digital-support-and-training
#39
JOURNAL ARTICLE
Santiago Gil Martinez, Pamela S Mbabazi, Motshedisi H Sebitloane, Bellington Vwalika, Sibone Mocumbi, Hashini N Galaphaththi-Arachchige, Sigve D Holmen, Bodo Randrianasolo, Borghild Roald, Femi Olowookorun, Francis Hyera, Sheila Mabote, Takalani G Nemungadi, Thembinkosi V Ngcobo, Tsakani Furumele, Patricia D Ndhlovu, Martin W Gerdes, Svein G Gundersen, Zilungile L Mkhize-Kwitshana, Myra Taylor, Roland E E Mhlanga, Eyrun F Kjetland
Up to 56 million young and adult women of African origin suffer from Female Genital Schistosomiasis (FGS). The transmission of schistosomiasis happens through contact with schistosomiasis infested fresh water in rivers and lakes. The transmission vector is the snail that releases immature worms capable of penetrating the human skin. The worm then matures and mates in the blood vessels and deposits its eggs in tissues, causing urogenital disease. There is currently no gold standard for FGS diagnosis. Reliable diagnostics are challenging due to the lack of appropriate instruments and clinical skills...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38497719/first-evidence-of-the-bioaccumulation-and-trophic-transfer-of-tire-additives-and-their-transformation-products-in-an-estuarine-food-web
#40
JOURNAL ARTICLE
Li-Ni Wei, Nian-Nian Wu, Ru Xu, Shan Liu, Heng-Xiang Li, Lang Lin, Rui Hou, Xiang-Rong Xu, Jian-Liang Zhao, Guang-Guo Ying
The discovery of the significant lethal impacts of the tire additive transformation product N -(1,3-dimethylbutyl)- N '-phenyl- p -phenylenediamine quinone (6PPD-Q) on coho salmon has garnered global attention. However, the bioaccumulation and trophic transfer of tire additives and their transformation products (TATPs) within food webs remain obscure. This study first characterized the levels and compositions of 15 TATPs in the Pearl River Estuary, estimated their bioaccumulation and trophic transfer potential in 21 estuarine species, and identified priority contaminants...
March 18, 2024: Environmental Science & Technology
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