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https://www.readbyqxmd.com/read/28339614/integrin-linked-kinase-regulates-syncytialization-of-bewo-trophoblast-cells%C3%A2
#1
Trina M Butler, Justin A Pater, Daniel J MacPhee
During placental development, mononuclear villous cytotrophoblast cells differentiate and fuse with the overlying syncytiotrophoblast. This process requires the dissolution of E-cadherin (CDH1)-containing adherens junctions in cytotrophoblast. Integrin linked kinase (ILK) can downregulate CDH1 through poly (ADP-ribose) polymerase 1 (PARP1) and Snail-1 (SNAI1) during epithelial-mesenchymal transition. ILK is known to be expressed in cytotrophoblast; thus, the role of a potential ILK-PARP1-SNAI1 pathway in aiding trophoblast syncytialization via the downregulation of CDH1 was examined...
January 27, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28337747/structure-dependent-effects-of-amyloid-%C3%AE-on-long-term-memory-in-lymnaea-stagnalis
#2
Lenzie Ford, Michael Crossley, Devkee M Vadukul, György Kemenes, Louise C Serpell
Amyloid-β (Aβ) peptides are implicated in the causation of memory loss, neuronal impairment, and neurodegeneration in Alzheimer's disease. Our recent work revealed that Aβ 1-42 and Aβ 25-35 inhibit long-term memory (LTM) recall in Lymnaea stagnalis (pond snail) in the absence of cell death. Here, we report the characterization of the active species prepared under different conditions, describe which Aβ species is present in brain tissue during the behavioral recall time point and relate the sequence and structure of the oligomeric species to the resulting neuronal properties and effect on LTM...
March 24, 2017: FEBS Letters
https://www.readbyqxmd.com/read/28337375/hmga2-regulates-cd44-expression-to-promote-gastric-cancer-cell-motility-and-sphere-formation
#3
Junying Sun, Baocun Sun, Dongwang Zhu, Xiulan Zhao, Yanhui Zhang, Xueyi Dong, Na Che, Jing Li, Fang Liu, Nan Zhao, Danfang Zhang, Tieju Liu, Xian Lin
High mobility group AT-hook 2 (HMGA2) is a transcriptional modulator that mediates motility and self-renewal in cancer stem cells. Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. GC contains a population of stem-like cells that promote tumor invasion and resistance to therapy. In the current study, we investigated the expression of HMGA2 and the cancer stem cell marker CD44 in 200 GC samples and found that HMGA2 and CD44 were significantly associated with distant metastasis, histological differentiation and poor prognosis in GC patients...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28335826/first-establishment-of-microsatellite-markers-in-clausiliid-snails-mollusca-gastropoda-clausiliidae
#4
Katharina Jaksch, Luise Kruckenhauser, Elisabeth Haring, Zoltán Fehér
BACKGROUND: Clausiliidae (door snails) are gastropods with a very high diversity concerning shell morphology, especially of their complex closing apparatus, which provides the most important diagnostic traits for classification of taxa. Due to the high variability, a high number of taxa has been described, though their systematics and taxonomy is partially controversially discussed. Montenegrina is the second most speciose door snail genus in Europe. It is an obligate rock-dwelling land snail and has, compared to its complex systematics, a rather small distribution range in the western parts of the Balkan Peninsula...
March 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28334022/effects-of-clothianidin-on-aquatic-communities-evaluating-the-impacts-of-lethal-and-sublethal-exposure-to-neonicotinoids
#5
Jesse C Miles, Jessica Hua, Maria S Sepulveda, Christian H Krupke, Jason T Hoverman
The widespread usage of neonicotinoid insecticides has sparked concern over their effects on non-target organisms. While research has largely focused on terrestrial systems, the low soil binding and high water solubility of neonicotinoids, paired with their extensive use on the landscape, puts aquatic environments at high risk for contamination via runoff events. We assessed the potential threat of these compounds to wetland communities using a combination of field surveys and experimental exposures including concentrations that are representative of what invertebrates experience in the field...
2017: PloS One
https://www.readbyqxmd.com/read/28332759/structural-adaptation-of-a-protein-to-increased-metal-stress-nmr-structure-of-a-marine-snail-metallothionein-with-an-additional-domain
#6
Christian Baumann, Andrea Beil, Simon Jurt, Michael Niederwanger, Oscar Palacios, Mercè Capdevila, Sílvia Atrian, Reinhard Dallinger, Oliver Zerbe
In this study, we present an NMR structure of the metallothionein (MT) from the snail Littorina littorea (LlMT) in complex with Cd(2+) . LlMT is capable of binding 9 Zn(2+) or 9 Cd(2+) ions. Sequence alignments with other snail MTs revealed that the protein is likely composed of three domains. The study revealed that the protein is divided into three individual domains, each of which folds into a single well-defined three-metal cluster. The central α2 and C-terminal β domains are positioned with a unique relative orientation...
March 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28332316/golph3-induces-epithelial-mesenchymal-transition-via-wnt-%C3%AE-catenin-signaling-pathway-in-epithelial-ovarian-cancer
#7
Jing Sun, Xiaoming Yang, Ru Zhang, Suqing Liu, Xupei Gan, Xiaowei Xi, Zhenbo Zhang, Youji Feng, Yunyan Sun
Golgi phosphoprotein 3 (GOLPH3), a newly recognized oncogene, is associated with tumor growth, metastasis, and poor prognosis in several types of cancer. However, its biological role and underlying mechanism in epithelial ovarian cancer (EOC) remain poorly understood. Here, we found that GOLPH3 was overexpressed in EOC tissues and cell lines. This overexpression promoted the migration and invasion of EOC cells. Moreover, GOLPH3 upregulated the expression of epithelial-mesenchymal transition (EMT) markers, such as N-cadherin and Snail, and the Wnt/β-catenin-related genes cyclin-D1 and c-Myc, which were restored via silencing of GOLPH3 expression...
March 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28331184/the-long-non-coding-rna-linc01013-enhances-invasion-of-human-anaplastic-large-cell-lymphoma
#8
I-Hsiao Chung, Pei-Hsuan Lu, Yang-Hsiang Lin, Ming-Ming Tsai, Yun-Wen Lin, Chau-Ting Yeh, Kwang-Huei Lin
Anaplastic large-cell lymphoma (ALCL) is a rare type of highly malignant, non-Hodgkin lymphoma (NHL). Currently, only studies on the chimeric oncogene NPM-ALK have reported a link to ALCL progression. However, the specific molecular mechanisms underlying the invasion of ALCL are still unclear. Here, we sought to investigate differentially expressed, long non-coding RNAs (lncRNAs) in ALCL and their potential biological function. Our microarray analyses revealed that LINC01013, a novel non-coding RNA gene, was highly expressed in clinical specimens of ALCL and was significantly upregulated in invasive ALCL cell lines...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330976/when-environmental-factors-become-stressors-interactive-effects-of-vermetid-gastropods-and-sedimentation-on-corals
#9
Julie A Zill, Michael A Gil, Craig W Osenberg
Environmental stressors often interact, but most studies of multiple stressors have focused on combinations of abiotic stressors. Here we examined the potential interaction between a biotic stressor, the vermetid snail Ceraesignum maximum, and an abiotic stressor, high sedimentation, on the growth of reef-building corals. In a field experiment, we subjected juvenile massive Porites corals to four treatments: (i) neither stressor, (ii) sedimentation, (iii) vermetids or (iv) both stressors. Unexpectedly, we found no effect of either stressor in isolation, but a significant decrease in coral growth in the presence of both stressors...
March 2017: Biology Letters
https://www.readbyqxmd.com/read/28330975/mitogenomes-and-relatedness-do-not-predict-frequency-of-tool-use-by-sea-otters
#10
Katherine Ralls, Nancy Rotzel McInerney, Roderick B Gagne, Holly B Ernest, M Tim Tinker, Jessica Fujii, Jesus Maldonado
Many ecological aspects of tool-use in sea otters are similar to those in Indo-Pacific bottlenose dolphins. Within an area, most tool-using dolphins share a single mitochondrial haplotype and are more related to each other than to the population as a whole. We asked whether sea otters in California showed similar genetic patterns by sequencing mitogenomes of 43 otters and genotyping 154 otters at 38 microsatellite loci. There were six variable sites in the mitogenome that yielded three haplotypes, one found in only a single individual...
March 2017: Biology Letters
https://www.readbyqxmd.com/read/28330919/moving-beyond-linear-food-chains-trait-mediated-indirect-interactions-in-a-rocky-intertidal-food-web
#11
Geoffrey C Trussell, Catherine M Matassa, Patrick J Ewanchuk
In simple, linear food chains, top predators can have positive indirect effects on basal resources by causing changes in the traits (e.g. behaviour, feeding rates) of intermediate consumers. Although less is known about trait-mediated indirect interactions (TMIIs) in more complex food webs, it has been suggested that such complexity dampens trophic cascades. We examined TMIIs between a predatory crab (Carcinus maenas) and two ecologically important basal resources, fucoid algae (Ascophyllum nodosum) and barnacles (Semibalanus balanoides), which are consumed by herbivorous (Littorina littorea) and carnivorous (Nucella lapillus) snails, respectively...
March 29, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28330510/an-integrated-environmental-improvement-of-marshlands-impact-on-control-and-elimination-of-schistosomiasis-in-marshland-regions-along-the-yangtze-river-china
#12
Le-Ping Sun, Wei Wang, Yin-Ping Zuo, Zheng-Qiu Zhang, Qing-Biao Hong, Guo-Jing Yang, Hong-Ru Zhu, You-Sheng Liang, Hai-Tao Yang
BACKGROUND: Schistosomiasis is a global snail-transmitted infectious disease of poverty. Transmission control had been achieved in China in 2015 after the control efforts for over 60 years. Currently, the remaining core regions endemic for Schistosoma japonicum are mainly located in the marshland and lake regions along the Yangtze River basin. METHODS: During the period from 2001 through 2015, an integrated environmental improvement of the marshlands was carried out through the implementation of industrial, agricultural and resources development projects in Yizheng County along the Yangtze River...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28329421/naproxen-inhibits-uvb-induced-basal-cell-and-squamous-cell-carcinoma-development-in-ptch1-skh-1-hairless-mice
#13
Sandeep C Chaudhary, Mohammad Waseem, Mehtab Rana, Hui Xu, Levy Kopelovich, Craig A Elmets, Mohammad Athar
Naproxen possesses anti-proliferative and pro-apoptotic effects besides its known anti-inflammatory functions. Here, we demonstrate the anti-cancer effects of naproxen against UVB-induced BCCs and SCCs in a highly susceptible murine model of UVB carcinogenesis. Naproxen significantly inhibited UVB-induced BCCs and SCCs in this model. Tumor number and volume were significantly decreased (p<0.005 and p<0.05, respectively). Inhibition in UVB-induced SCCs and BCCs was 77% and 86%, respectively, which was associated with reduced PCNA and cyclin D1 and increased apoptosis...
March 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28327967/genome-sequence-of-pacific-abalone-haliotis-discus-hannai-the-first-draft-genome-in-family-haliotidae
#14
Bo-Hye Nam, Woori Kwak, Young-Ok Kim, Dong-Gyun Kim, Hee Jeong Kong, Woo-Jin Kim, Jeong-Ha Kang, Jung Youn Park, Cheul Min An, Ji-Young Moon, Choul Ji Park, Jae Woong Yu, Joon Yoon, Minseok Seo, Kwondo Kim, Duk Kyung Kim, SaetByeol Lee, Samsun Sung, Chul Lee, Younhee Shin, Myunghee Jung, Byeong-Chul Kang, Shin Ga-Hee, Sojeong Ka, Kelsey Caetano-Anolles, Seoae Cho, Heebal Kim
Background: Abalones are large marine snails in the family Haliotidae and the genus Haliotis belonging to the class Gastropoda of the phylum Mollusca. The family Haliotidae contains only one genus, Haliotis, and this single genus is known to contain several species of abalone. With 18 additional subspecies, the most comprehensive treatment of Haliotidae considers 56 species valid [1]. Abalone is an economically important fishery and aquaculture animal which is considered a highly-prized seafood delicacy...
March 7, 2017: GigaScience
https://www.readbyqxmd.com/read/28327808/prevalence-and-distribution-of-angiostrongylus-cantonensis-nematoda-angiostrongylidae-in-achatina-fulica-mollusca-gastropoda-in-baixada-santista-s%C3%A3-o-paulo-brazil
#15
Laura Rocha Guerino, Iracy Lea Pecora, Marcel Sabino Miranda, Cryslaine Aguiar-Silva, Omar Dos Santos Carvalho, Roberta Lima Caldeira, Reinaldo José da Silva
INTRODUCTION: Angiostrongylus cantonensis is causes eosinophilic meningoencephalitis in humans. Worldwide expansion of this nematode is linked to the dispersion of their hosts. This study aimed to determine the prevalence of A. cantonensis infection in Achatina fulica in the nine municipalities that make up Baixada Santista, São Paulo, Brazil. METHODS: Angiostrongylus cantonensis larvae were analyzed using optical microscopy. We performed polymerase chain reaction and restriction fragment length polymorphism using restriction endonuclease ClaI, directed to the internal transcribed spacer region 2 of A...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327187/schistosomiasis-is-more-prevalent-than-previously-thought-what-does-it-mean-for-public-health-goals-policies-strategies-guidelines-and-intervention-programs
#16
REVIEW
Daniel G Colley, Tamara S Andros, Carl H Campbell
Mapping and diagnosis of infections by the three major schistosome species (Schistosoma haematobium, S. mansoni and S. japonicum) has been done with assays that are known to be specific but increasingly insensitive as prevalence declines or in areas with already low prevalence of infection. This becomes a true challenge to achieving the goal of elimination of schistosomiasis because the multiplicative portion of the life-cycle of schistosomes, in the snail vector, favors continued transmission as long as even a few people maintain low numbers of worms that pass eggs in their excreta...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28325369/the-compatibility-between-biomphalaria-glabrata-snails-and-schistosoma-mansoni-an-increasingly-complex-puzzle
#17
G Mitta, B Gourbal, C Grunau, M Knight, J M Bridger, A Théron
This review reexamines the results obtained in recent decades regarding the compatibility polymorphism between the snail, Biomphalaria glabrata, and the pathogen, Schistosoma mansoni, which is one of the agents responsible for human schistosomiasis. Some results point to the snail's resistance as explaining the incompatibility, while others support a "matching hypothesis" between the snail's immune receptors and the schistosome's antigens. We propose here that the two hypotheses are not exclusive, and that the compatible/incompatible status of a particular host/parasite couple probably reflects the balance of multiple molecular determinants that support one hypothesis or the other...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28322937/snail-induced-epithelial-to-mesenchymal-transition-enhances-p-gp-mediated-multi-drug-resistance-in-hcc827-cells
#18
Takumi Tomono, Kentaro Yano, Takuo Ogihara
Overexpression and/or activation of P-glycoprotein (P-gp), which mediates efflux transport of various anti-cancer drugs in cancer cells, are associated with multi-drug resistance (MDR). On the other hand, malignant cancer cells frequently undergo epithelial-to-mesenchymal transition (EMT), thereby acquiring high migratory mobility and invasive ability. Snail is a transcriptional factor that represses multiple other factors, and its overexpression is a trigger of EMT. Since both P-gp and Snail are involved in malignant evolution of cancer, in this work, we evaluated whether or not EMT induced by overexpression of Snail influences P-gp expression and/or activity...
March 17, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28322934/comparative-immunogenomics-of-molluscs
#19
Jonathan H Schultz, Coen M Adema
Comparative immunology, studying both vertebrates and invertebrates, provided the earliest descriptions of phagocytosis as a general immune mechanism. However, the large scale of animal diversity challenges all-inclusive investigations and the field of immunology has developed by mostly emphasizing study of a few vertebrate species. In addressing the lack of comprehensive understanding of animal immunity, especially that of invertebrates, comparative immunology helps toward management of invertebrates that are food sources, agricultural pests, pathogens, or transmit diseases, and helps interpret the evolution of animal immunity...
March 18, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28322847/identification-and-functional-characterization-of-oncomelania-hupensis-macrophage-migration-inhibitory-factor-involved-in-the-snail-host-innate-immune-response-to-the-parasite-schistosoma-japonicum
#20
Shuaiqin Huang, Yunchao Cao, Mingke Lu, Wenfeng Peng, Jiaojiao Lin, Chongti Tang, Liang Tang
Schistosomiasis, caused by parasitic trematodes of the genus Schistosoma, remains a devastating public health problem, with over 200 million people infected and 779 million people at risk worldwide, especially in developing countries. The freshwater amphibious snail Oncomelania hupensis is the obligate intermediate host of Schistosoma japonicum. This unique and long-standing host-parasite interaction highlights the biomedical importance of the molecular and cellular mechanisms involved in the snail immune defense response against schistosome infection...
March 18, 2017: International Journal for Parasitology
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