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Stat 3 IL6 cancer

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https://www.readbyqxmd.com/read/25163167/multiscale-agent-based-modelling-of-ovarian-cancer-progression-under-the-stimulation-of-the-stat-3-pathway
#1
Le Zhang, Yao Xue, Beini Jiang, Costas Strouthos, Zhenfeng Duan, Yukun Wu, Jing Su, Xiaobo Zhou
This research is developed to simulate ovarian cancer progression with signal transducers and activators of the transcription 3 (STAT 3) pathway. The main focus is on studying how the STAT 3 pathway affects the cancer cells' biomechanical phenotype under the stimulation of the interleukin-6 (IL-6) cytokine and various well-known microscopic factors. The simulated results agreed with recent experimental evidence that ovarian cancer cells with a stimulated STAT 3 pathway have high survival rates and drug resistance...
2014: International Journal of Data Mining and Bioinformatics
https://www.readbyqxmd.com/read/24434062/epithelial-gp130-stat3-functions-an-intestinal-signaling-node-in-health-and-disease
#2
REVIEW
Matthias Ernst, Stefan Thiem, Paul M Nguyen, Moritz Eissmann, Tracy L Putoczki
A contiguous intestinal epithelial barrier safeguards against aberrant activation of the immune system and therefore requires molecular mechanisms that ensure effective wound-healing responses. During this processes cytokine-producing myeloid cells serve as rheostats that link the degree of wounding and local inflammation to the epithelial repair response. Likewise, intestinal inflammation is an important factor by which the microenvironment promotes tumorigenesis and the progression of established cancers by facilitating neoplastic cell survival and proliferation...
February 2014: Seminars in Immunology
https://www.readbyqxmd.com/read/22121102/jak-stat-socs-signaling-pathway-and-colon-and-rectal-cancer
#3
Martha L Slattery, Abbie Lundgreen, Susan A Kadlubar, Kristina L Bondurant, Roger K Wolff
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in immune function and cell growth. We evaluated the association between genetic variation in JAK1 (10 SNPs), JAK2 (9 SNPs), TYK2 (5 SNPs), suppressors of cytokine signaling (SOCS)1 (2 SNPs), SOCS2 (2 SNPs), STAT1 (16 SNPs), STAT2 (2 SNPs), STAT3 (6 SNPs), STAT4 (21 SNPs), STAT5A (2 SNPs), STAT5B (3 SNPs), STAT6 (4 SNPs) with risk of colorectal cancer. We used data from population-based case-control studies (colon cancer nā€‰=ā€‰1555 cases, 1,956 controls; rectal cancer nā€‰=ā€‰754 cases, 959 controls)...
February 2013: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/21619876/the-r-h-oads-to-stat3-stat3-activation-by-the-rho-gtpases
#4
REVIEW
Leda Raptis, Rozanne Arulanandam, Mulu Geletu, James Turkson
The signal transducer and activator of transcription-3 (Stat3) is a member of the STAT family of cytoplasmic transcription factors. Overactivation of Stat3 is detected with high frequency in human cancer and is considered a molecular abnormality that supports the tumor phenotype. Despite concerted investigative efforts, the molecular mechanisms leading to the aberrant Stat3 activation and Stat3-mediated transformation and tumorigenesis are still not clearly defined. Recent evidence reveals a crosstalk close relationship between Stat3 signaling and members of the Rho family of small GTPases, including Rac1, Cdc42 and RhoA...
August 1, 2011: Experimental Cell Research
https://www.readbyqxmd.com/read/19088723/cross-talk-of-signals-between-egfr-and-il-6r-through-jak2-stat3-mediate-epithelial-mesenchymal-transition-in-ovarian-carcinomas
#5
M Colomiere, A C Ward, C Riley, M K Trenerry, D Cameron-Smith, J Findlay, L Ackland, N Ahmed
Epidermal growth factor receptor (EGFR) is overexpressed in ovarian carcinomas, with direct or indirect activation of EGFR able to trigger tumour growth. We demonstrate significant activation of both signal transducer and activator of transcription (STAT)3 and its upstream activator Janus kinase (JAK)2, in high-grade ovarian carcinomas compared with normal ovaries and benign tumours. The association between STAT3 activation and migratory phenotype of ovarian cancer cells was investigated by EGF-induced epithelial-mesenchymal transition (EMT) in OVCA 433 and SKOV3 ovarian cancer cell lines...
January 13, 2009: British Journal of Cancer
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