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https://www.readbyqxmd.com/read/29778322/history-of-non-muscle-invasive-bladder-cancer-may-have-a-worse-prognostic-impact-in-ct2-4an0m0-bladder-cancer-patients-treated-with-radical-cystectomy
#1
Emina Kayama, Eiji Kikuchi, Keishiro Fukumoto, Suguru Shirotake, Yasumasa Miyazaki, Kyohei Hakozaki, Gou Kaneko, Shunsuke Yoshimine, Nobuyuki Tanaka, Maeda Takahiro, Kunimitsu Kanai, Masafumi Oyama, Yosuke Nakajima, Satoshi Hara, Tetsuo Monma, Mototsugu Oya
PURPOSE: To investigate whether a history of non-muscle-invasive bladder cancer (NMIBC) plays a prognostic role in patients with muscle-invasive bladder cancer (MIBC) treated with radical cystectomy in the era when neoadjuvant chemotherapy was established as standard therapy for MIBC. PATIENTS AND METHODS: A total of 282 patients who were diagnosed with cT2-T4aN0M0 bladder cancer treated with open radical cystectomy at our institutions were included. Initially diagnosed MIBC without a history of NMIBC was defined as primary MIBC group (n = 231), and MIBC that progressed from NMIBC was defined as progressive MIBC (n = 51)...
April 28, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29776013/prognostic-pathologic-factors-in-radical-cystectomy-after-neoadjuvant-chemotherapy
#2
Fadi Brimo, Michelle R Downes, Tamara Jamaspishvili, David Berman, Guliz A Barkan, Daniel Athanazio, Schuharazad Abro, Kash Visram, Asli Yilmaz, Shraddha Solanki, Elan Hahn, Robert Siemens, Wassim Kassouf, Kiril Trpkov
We undertook a systematic evaluation of the prognostic value of numerous histologic factors in 165 radical cystectomies (RC) of patients with invasive urothelial carcinoma who underwent surgery after neoadjuvant chemotherapy (NAC). Tumor regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0+pN0) and 28% had no evidence of residual muscle invasive carcinoma (≤pT1+N0)...
May 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29774811/robot-assisted-radical-cystectomy-in-men-technique-of-spaces
#3
Youssef E Ahmed, Ahmed A Hussein, Justen Kozlowski, Khurshid A Guru
The past decade has witnessed a dramatic increase in utilization of robot-assisted radical cystectomy (RARC). RARC has been shown to offer some perioperative benefits in terms of blood loss, transfusion rates, hospital stay, and recovery when compared with its open counterpart without jeopardizing oncologic outcomes. In this article, we review the indications, perioperative care, and describe the "Technique of Spaces" of RARC employed at our institution, and highlight the key steps for male RARC.
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774757/extended-pelvic-lymph-node-dissection-in-bladder-cancer
#4
Roger Li, Firas G Petros, John W Davis
INTRODUCTION: Radical cystectomy and extended pelvic lymph node dissection (ePLND) are the gold standard treatment for muscle-invasive bladder cancer and BCG unresponsive nonmuscle-invasive bladder cancer. In this article, we review the rationale for ePLND in the treatment of bladder cancer and the evidence supporting the equipoise between robot-assisted (RA) and open ePLND. A step-by-step guide of robot-assisted ePLND (RA ePLND) is provided to illustrate the techniques currently employed at our institution...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29768132/post-operative-infections-among-patients-undergoing-radical-cystectomy-at-a-tertiary-center
#5
Krystian Kaczmarek, Artur Lemiński, Aleksandra Bańcarz, Alicja Zakrzewska, Marcin Słojewski
BACKGROUND: Post-operative infection after radical cystectomy is a common complication. It is essential to identify modifiable risk factors that can predict post-operative infection to reduce the incidence of infection after radical cystectomy. We investigated the incidence of post-operative infection, associated pathogens, and risk factors for post-operative infection after radical cystectomy. PATIENTS AND METHODS: Patients who underwent radical cystectomy for bladder cancer in a single urologic department from 2014 to 2016 were included...
May 2018: Surgical Infections
https://www.readbyqxmd.com/read/29765120/oncological-outcome-of-primary-and-secondary-muscle-invasive-bladder-cancer-a-systematic-review-and-meta-analysis
#6
Peng Ge, Li Wang, Meng Lu, Lijun Mao, Wang Li, Rumin Wen, Jian Lin, Junqi Wang, Jiacun Chen
Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIBC. Due to the varying reports, we conducted a systematic review and meta-analysis to compare survival outcomes between the two groups. Relevant studies were retrieved from Medline, Embase, the Cochrane Library, and Scopus using a comprehensive search approach...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29761225/pathological-characteristics-and-prognostic-indicators-of-different-histopathological-types-of-urinary-bladder-cancer-following-radical-cystectomy-in-a-large-single-center-egyptian-cohort
#7
Jeremy W Martin, Simone L Vernez, Yair Lotan, Ahmed Abdelhalim, Rahul Dutta, Ahmed Shokeir, Hassan Abol-Enein, Ahmed Mosbah, Mohamed Ghoneim, Ramy F Youssef
OBJECTIVE: To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients. METHODS: A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan-Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS)...
May 14, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29757568/acute-kidney-injury-following-radical-cystectomy-and-urinary-diversion-predictors-and-associated-morbidity
#8
Yasser Osman, Ahmed M Harraz, Samer El-Halwagy, Mahmoud Laymon, Ahmed Mosbah, Hassan Abol-Enein, Atalla A Shaaban
INTRODUCTION: Acute kidney injury (AKI) after major surgeries is associated with significant morbidity and mortality. We aim to report incidence, predictors and associated comorbidities of AKI after radical cystectomy in a large cohort of patients. MATERIALS AND METHODS: We conducted a retrospective analysis of 1000 patients who underwent open radical cystectomy in a tertiary referral center. Perioperative serum creatinine measurements were used to define AKI according to the RIFLE criteria (as Risk, Injury and Failure)...
March 18, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29755116/health-related-quality-of-life-after-treatment-for-bladder-cancer-in-england
#9
Samantha J Mason, Amy Downing, Penny Wright, Luke Hounsome, Sarah E Bottomley, Jessica Corner, Mike Richards, James W Catto, Adam W Glaser
BACKGROUND: Little is known about quality of life after bladder cancer treatment. This common cancer is managed using treatments that can affect urinary, sexual and bowel function. METHODS: To understand quality of life and inform future care, the Department of Health (England) surveyed adults surviving bladder cancer 1-5 years after diagnosis. Questions related to disease status, co-existing conditions, generic health (EQ-5D), cancer-generic (Social Difficulties Inventory) and cancer-specific outcomes (Functional Assessment of Cancer Therapy-Bladder)...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29752514/overall-survival-in-patients-with-residual-disease-after-radical-cystectomy-and-neoadjuvant-chemotherapy
#10
Izak Faiena, Amirali Salmasi, Neil Mendhiratta, Andrew T Lenis, Aydin Pooli, Alexandra Drakaki, Kiran Gollapudi, Jeremy Blumberg, Allan J Pantuck, Karim Chamie
BACKGROUND: Neoadjuvant chemotherapy (NAC) has been shown to improve survival in patients with urothelial carcinoma (UC). However, there are a subset of patients who do not respond or progress despite systemic treatment. METHODS: Data from the National Cancer Database on patients who underwent a radical cystectomy (RC) with or without NAC from 2006 to 2013 were abstracted. Covariates were balanced using inverse probability weighting methods. The primary outcome of overall survival in patients with residual disease by stage was evaluated using 90-day conditional landmark analysis and Cox proportional hazards modeling...
May 11, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29750321/improved-outcomes-of-enhanced-recovery-after-surgery-eras-protocol-for-radical-cystectomy-with-addition-of-a-multidisciplinary-care-process-in-a-us-comprehensive-cancer-care-center
#11
Sephalie Y Patel, Rosemarie E Garcia Getting, Brandon Alford, Karim Hussein, Braydon J Schaible, David Boulware, Jae K Lee, Scott M Gilbert, Julio M Powsang, Wade J Sexton, Philippe E Spiess, Michael A Poch
INTRODUCTION: Although enhanced recovery after surgery (ERAS) components include both anesthesia and surgical care processes, it is unclear whether a multidisciplinary approach to implementing ERAS care processes improves clinical outcomes. The addition of multidisciplinary care with anesthesiology-related components to an existing ERAS protocol for radical cystectomy at a US comprehensive cancer center provided an opportunity to compare short- and long-term outcomes. METHODS: We retrospectively compared the outcomes of 116 consecutive patients who underwent cystectomy after implementation of a multidisciplinary ERAS protocol with those of a historical control group of 143 consecutive patients who had been treated with a surgical ERAS protocol...
May 10, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29744601/asymptomatic-recurrence-detection-and-cost-effectiveness-in-urothelial-carcinoma
#12
REVIEW
Hiromichi Iwamura, Shingo Hatakeyama, Makoto Sato, Chikara Ohyama
For the management of muscle-invasive bladder cancer or upper tract urothelial carcinoma, the set guidelines recommend regular surveillance after radical cystectomy or radical nephroureterectomy. However, the prognostic benefit of regular oncological surveillance remains controversial in the absence of prospective studies although several retrospective studies with relatively large sample sizes have demonstrated the association between asymptomatic recurrence and better oncological outcomes. Seven out of eight studies reported that patients diagnosed with symptomatic recurrence showed significantly poorer prognosis in comparison to those diagnosed with asymptomatic recurrence...
May 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29744571/perioperative-outcomes-and-complications-of-intracorporeal-vs-extracorporeal-urinary-diversion-after-robot-assisted-radical-cystectomy-for-bladder-cancer-a-real-life-multi-institutional-french-study
#13
Louis Lenfant, Gregory Verhoest, Riccardo Campi, Jérôme Parra, Vivien Graffeille, Alexandra Masson-Lecomte, Dimitri Vordos, Alexandre de La Taille, Mathieu Roumiguie, Marine Lesourd, Lionel Taksin, Vincent Misraï, Pietro Grande, Christophe Vaessen, Guillaume Ploussard, Benjamin Granger, Morgan Rouprêt
PURPOSE: To compare perioperative outcomes and complications of extracorporeal (ECUD) vs intracorporeal urinary diversion (ICUD) in patients after undergoing robot-assisted radical cystectomy (RARC) at five referral centers in France. METHODS: We retrospectively reviewed our multi-institutional, prospectively-collected database to select patients undergoing RARC between 2010 and 2016 with at least 3 months of follow-up. At each center, the surgery was performed by one surgeon with extensive experience in robotic surgery and radical cystectomy but no prior experience in RARC...
May 9, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29742009/multicenter-prospective-phase-ii-trial-of-neoadjuvant-dose-dense-gemcitabine-plus-cisplatin-in-patients-with-muscle-invasive-bladder-cancer
#14
Gopa Iyer, Arjun V Balar, Matthew I Milowsky, Bernard H Bochner, Guido Dalbagni, S Machele Donat, Harry W Herr, William C Huang, Samir S Taneja, Michael Woods, Irina Ostrovnaya, Hikmat Al-Ahmadie, Maria E Arcila, Jamie C Riches, Andreas Meier, Caitlin Bourque, Maha Shady, Helen Won, Tracy L Rose, William Y Kim, Brooke E Kania, Mariel E Boyd, Catharine K Cipolla, Ashley M Regazzi, Daniela Delbeau, Asia S McCoy, Hebert Alberto Vargas, Michael F Berger, David B Solit, Jonathan E Rosenberg, Dean F Bajorin
Purpose Neoadjuvant chemotherapy followed by radical cystectomy (RC) is a standard of care for the management of muscle-invasive bladder cancer (MIBC). Dose-dense cisplatin-based regimens have yielded favorable outcomes compared with standard-dose chemotherapy, yet the optimal neoadjuvant regimen remains undefined. We assessed the efficacy and tolerability of six cycles of neoadjuvant dose-dense gemcitabine and cisplatin (ddGC) in patients with MIBC. Patients and Methods In this prospective, multicenter phase II study, patients received ddGC (gemcitabine 2,500 mg/m2 on day 1 and cisplatin 35 mg/m2 on days 1 and 2) every 2 weeks for 6 cycles followed by RC...
May 9, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29733795/muscle-invasive-bladder-and-urethral-cancer-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-review-of-305-patients
#15
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Samer El-Halwagy
OBJECTIVE: Bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC) is a common disease. Although the incidence and risk factors for the development of noninvasive bladder tumor have been reported in many series, rare studies have reported on muscle invasive bladder cancer (MIBC) and its urethral recurrence. We aimed to report the incidence, risk factors and survival rate for the development of MIBC and urethral tumors after surgical management of UTUC. MATERIAL AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29733363/bacillus-calmette-gu%C3%A3-rin-may-have-clinical-benefit-for-glandular-or-squamous-differentiation-in-non-muscle-invasive-bladder-cancer-patients-retrospective-multicenter-study
#16
Wakako Yorozuya, Naotaka Nishiyama, Tetsuya Shindo, Yuki Kyoda, Naoki Itoh, Shintaro Sugita, Tadashi Hasegawa, Naoya Masumori
Objectives: To clarify the efficacy of intravesical Bacillus Calmette-Guérin (BCG) instillation for non-muscle invasive bladder (NMIBC) cancer with variant histology, especially glandular differentiation or squamous differentiation. Materials and methods: From May 1991 through June 2016, 53 patients were diagnosed retrospectively as having NMIBC with variant histology. Among these patients, 47 NMIBC patients with squamous differentiation or glandular differentiation were analyzed for this study...
May 4, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29733077/challenges-facing-regionalization-of-radical-cystectomy
#17
EDITORIAL
David B Cahn, Christopher Foote, Marc C Smaldone
No abstract text is available yet for this article.
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29732390/prognostication-in-patients-treated-with-radical-cystectomy-for-urothelial-bladder-carcinoma-a-new-simplified-model-incorporating-histological-variants
#18
Ja Hyeon Ku, Hyeong Dong Yuk, Guiherme Godoy, Gilard E Amiel, Seth P Lerner
Purpose: The aim of this study was to evaluate the clinical significance of histological variants (HV) and to develop a new and simple prediction model incorporating variant forms in patients who underwent radical cystectomy for urothelial carcinoma (UC). Materials and methods: We analyzed the data of 365 patients. We evaluated whether HV were independent predictors of survival. A new scoring model was developed using the regression coefficients from the multivariate Cox proportional hazard model...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732387/transversus-abdominis-plane-blockade-as-part-of-a-multimodal-postoperative-analgesia-plan-in-patients-undergoing-radical-cystectomy
#19
Richard S Matulewicz, Mehul Patel, Brian J Jordan, Jacqueline Morano, Brendan Frainey, Yasin Bhanji, Mahreen Bux, Antoun Nader, Shilajit D Kundu, Joshua J Meeks
Background: Radical cystectomy (RC) is a morbid procedure with frequent complications that may benefit from implementation of an enhanced recovery after surgery (ERAS) protocol. Objective: To examine the benefits of a multimodal analgesic plan that uses continuous transversus abdominis plane (TAP) blockade as part of an ERAS protocol after RC. Methods: A retrospective comparison of consecutive patients undergoing RC over a 4-year period was conducted...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732385/thromboembolism-in-patients-with-bladder-cancer-incidence-risk-factors-and-prevention
#20
REVIEW
Piotr Zareba, Wilhelmina C M Duivenvoorden, Jehonathan H Pinthus
Patients with bladder cancer are at high risk of developing both venous and arterial thromboembolic events. Factors that contribute to this phenomenon include the hypercoagulable state induced by the malignancy itself, medical comorbidities that are common in this predominantly elderly patient population as well as treatments such as prolonged pelvic surgery and cisplatin-based chemotherapy. While formal guidelines address prevention of venous thromboembolism in patients undergoing radical cystectomy, consensus regarding the role of pharmacologic prophylaxis in patients with bladder cancer being treated with chemotherapy, either with neoadjuvant or adjuvant intent in conjunction with radical cystectomy, as part of bladder preservation protocols or for metastatic disease, has proved elusive...
April 26, 2018: Bladder Cancer
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