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https://www.readbyqxmd.com/read/28923108/a-low-psoas-muscle-volume-correlates-with-a-longer-hospitalization-after-radical-cystectomy
#1
Yoko Saitoh-Maeda, Takashi Kawahara, Yasuhide Miyoshi, Sohgo Tsutsumi, Daiji Takamoto, Kota Shimokihara, Yuutaro Hayashi, Taku Mochizuki, Mari Ohtaka, Manami Nakamura, Yusuke Hattori, Jun-Ichi Teranishi, Yasushi Yumura, Kimito Osaka, Hiroki Ito, Kazuhide Makiyama, Noboru Nakaigawa, Masahiro Yao, Hiroji Uemura
BACKGROUND: Recently, sarcopenia has been reported as a new predictor for patient outcomes or likelihood of post-operative complications. The purpose of this study was to evaluate the association of the psoas muscle volume with the length of hospitalization among patients undergoing radical cystectomy. METHODS: A total of 63 (80.8%) male patients and 15 (19.2%) female patients who underwent radical cystectomy for their bladder cancer in our institution from 2000 to 2015 were analyzed...
September 18, 2017: BMC Urology
https://www.readbyqxmd.com/read/28919521/treatment-patterns-and-survival-outcomes-for-patients-with-small-cell-carcinoma-of-the-bladder
#2
Benjamin W Fischer-Valuck, Yuan James Rao, Lauren E Henke, Soumon Rudra, Caressa Hui, Brian C Baumann, Hiram A Gay, Jeff M Michalski
BACKGROUND: Small cell carcinoma of the bladder (SCCaB) is a rare tumor without a standard treatment algorithm. Treatment patterns and survival outcomes from the National Cancer Database (NCDB) may provide insight into optimal treatment strategies. OBJECTIVE: To investigate the relationship between overall survival (OS) and treatment strategy. DESIGN, SETTING, AND PARTICIPANTS: This was an observational study of treatment-naïve patients who received treatment from 2004 to 2013...
September 14, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28915599/copy-number-variations-of-circulating-cell-free-dna-in-urothelial-carcinoma-of-the-bladder-patients-treated-with-radical-cystectomy-a-prospective-study
#3
Armin Soave, Felix K-H Chun, Timo Hillebrand, Michael Rink, Lars Weisbach, Bettina Steinbach, Margit Fisch, Klaus Pantel, Heidi Schwarzenbach
The aim of the present study was to establish a rapid profiling method using multiplex ligation-dependent probe amplification (MLPA) and characterize copy number variations (CNV) in circulating, cell-free DNA (cfDNA) in 85 urothelial carcinoma of the bladder (UCB) patients treated with radical cystectomy (RC). MLPA was tested for the use of cfDNA extracted from serum and plasma by various commercial extraction kits. Eighteen probes served as reference to control denaturation, ligation and amplification efficiency...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913657/radical-cystectomy-for-recurrent-urothelial-carcinoma-after-prior-partial-cystectomy-perioperative-and-oncologic-outcomes
#4
Ross J Mason, Igor Frank, Bimal Bhindi, Matthew K Tollefson, R Houston Thompson, R Jeffrey Karnes, Robert Tarrell, Prabin Thapa, Stephen A Boorjian
PURPOSE: To evaluate perioperative and oncologic outcomes of patients undergoing radical cystectomy (RC) for recurrence of urothelial carcinoma (UC) after prior partial cystectomy (PC), and to compare these outcomes to patients undergoing primary RC. METHODS: Patients who underwent RC for recurrence of UC after prior PC were matched 1:3 to patients undergoing primary RC based on age, pathologic stage, and decade of surgery. Perioperative and oncologic outcomes were compared using Wilcoxon sign-rank test, McNemars test, the Kaplan-Meier method, and Cox proportional hazards regression analyses...
September 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28905486/perioperative-allogeneic-blood-transfusion-does-not-adversely-impact-oncological-outcomes-after-radical-cystectomy-for-urinary-bladder-cancer-a-propensity-score-weighted-european-multicenter-study
#5
Malte W Vetterlein, Philipp Gild, Luis A Kluth, Thomas Seisen, Michael Gierth, Hans-Martin Fritsche, Maximilian Burger, Chris Protzel, Oliver W Hakenberg, Nicolas von Landenberg, Florian Roghmann, Joachim Noldus, Philipp Nuhn, Armin Pycha, Michael Rink, Felix K-H Chun, Matthias May, Margit Fisch, Atiqullah Aziz
OBJECTIVES: To evaluate the effect of perioperative blood transfusion (PBT) on recurrence-free survival (RFS), overall survival (OS), cancer-specific mortality (CSM), and other-cause mortality (OCM) in patients undergoing radical cystectomy (RC), utilizing a contemporary European multicenter cohort. PATIENTS AND METHODS: The PROspective MulticEnTer RadIcal Cystectomy Series (PROMETRICS) includes data on 679 patients who underwent RC at 18 European tertiary care centers in 2011...
September 14, 2017: BJU International
https://www.readbyqxmd.com/read/28900840/risks-and-benefits-of-pelvic-lymphadenectomy-in-octogenarians-undergoing-radical-cystectomy-due-to-urothelial-carcinoma-of-the-bladder
#6
M Grabbert, T Grimm, A Buchner, A Kretschmer, M Apfelbeck, G Schulz, F Jokisch, B-S Schneevoigt, C G Stief, A Karl
OBJECTIVES: According to current guidelines, radical cystectomy (RC) should be combined with an extended pelvic lymphadenectomy (PLND) as therapeutic and staging instrument. Objective of this study was to analyze the influence of PLND on survival rates and complication rates in a selected group of elderly patients with a minimum age of 80 years. MATERIALS AND METHODS: In this single-center retrospective analysis, we evaluated 102 patients who underwent RC due to UCB from 2004 to 2015 at our institution...
September 12, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28899722/effect-of-nonurothelial-histologic-variants-on-the-outcomes-of-radical-cystectomy-for-nonmetastatic-muscle-invasive-urinary-bladder-cancer
#7
Malte W Vetterlein, Thomas Seisen, Jeffrey J Leow, Mark A Preston, Maxine Sun, David F Friedlander, Christian P Meyer, Felix K-H Chun, Stuart R Lipsitz, Mani Menon, Adam S Kibel, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
INTRODUCTION: Knowledge of the comparative oncologic outcomes of histologic variants after radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) relies on small case series. We compared the effect of pure squamous cell carcinoma, adenocarcinoma, and neuroendocrine carcinoma compared with pure urothelial carcinoma (PUC) on overall survival (OS) and pathologic tumor, lymph node, and surgical margin status after RC. PATIENTS AND METHODS: Using the National Cancer Database, we retrospectively examined patients undergoing RC for MIBC from 2003 to 2011...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28895201/long-term-kidney-transplant-survival-in-patients-with-continent-urinary-diversion
#8
Romain Fournier, Ricardo Codas-Duarte, Theresa Daily, Xavier Martin, Lionel Badet, Hakim Fassi-Fehri
OBJECTIVES: To report the long-term survival of transplanted kidneys in patients with a continent urinary diversion. METHODS: Between January 1987 and July 2015, 16 patients with a median age of 37 years (range 21-63 years) underwent kidney transplantation on a continent urinary diversion. A total of 14 patients presented irreversible dysfunction of the lower urinary tract, and two patients had required radical cystectomy because of bladder cancer. All continent urinary diversions were carried out before the transplantation...
September 11, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28890901/performing-all-major-surgical-procedures-robotically-will-prolong-wait-times-for-surgery
#9
Brian M Shinder, Nicholas J Farber, Robert E Weiss, Thomas L Jang, Isaac Y Kim, Eric A Singer, Sammy E Elsamra
This article aimed to assess the burden of scheduling major urologic oncology procedures if all cases were performed robotically and to determine whether this would increase the time a patient would have to wait for surgery. We retrospectively determined the number of prostatectomies, radical nephrectomies, partial nephrectomies, and cystectomies at a single institution for one calendar year. A hypothetical situation was then constructed where all procedures were performed robotically. Using the allotted number of days that each surgeon was able to schedule robotic procedures, we analyzed the amount of time it would take to schedule and complete all cases...
2017: Robot Surg
https://www.readbyqxmd.com/read/28890392/natural-history-and-predictors-of-parastomal-hernia-after-robot-assisted-radical-cystectomy-and-ileal-conduit-urinary-diversion
#10
Ahmed A Hussein, Youssef E Ahmed, Paul May, Taimoor Ali, Basim Ahmad, Sana Raheem, Kevin Stone, Adam Hasasnah, Omer Rana, Adam Cole, Derek Wang, Peter Loud, Khurshid A Guru
INTRODUCTION: We investigated the prevalence, variables associated with parastomal hernia (PSH), and its outcomes of after robot-assisted radical cystectomy (RARC) and ileal conduit (IC) for bladder cancer. METHODS: Retrospective review of RARC at our institution was conducted. PSH was defined as protrusion of abdominal contents through the stoma defect in the abdominal wall on cross sectional imaging. PSH was further described in terms of patient and hernia characteristics, symptoms, management and outcomes...
September 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28888228/transperineal-cryotherapy-for-unresectable-muscle-invasive-bladder-cancer-preliminary-experience-with-7-male-patients
#11
Qing Zhang, Shiwei Zhang, Shun Zhang, Wei Wang, Xiaozhi Zhao, Yongming Deng, Huibo Lian, Hongqian Guo
BACKGROUND: Radical cystectomy (RC) with pelvic lymph node dissection (PLND) and urinary diversion (UD) is considered the standard treatment for muscle invasive bladder cancer (MIBC). In a part of patients, RC procedure is aborted due to unresectable disease, other followed treatment like systemic chemotherapy, radiotherapy or cryotherapy may be a better option. The aim of present study was to report the preliminary results of transperineal cryotherapy for unresectable muscle invasive bladder cancer...
September 9, 2017: BMC Urology
https://www.readbyqxmd.com/read/28887096/predicting-local-failure-after-radical-cystectomy-in-patients-with-bladder-cancer-implications-for-the-selection-of-candidates-at-adjuvant-radiation-therapy
#12
Marco Moschini, Shahrokh F Shariat, Mohammad Abufaraj, Beat Foerster, David D Andrea, Francesco Soria, Paolo Dell Oglio, Agostino Mattei, Francesco Montorsi, Renzo Colombo, Alberto Briganti, Andrea Gallina
OBJECTIVE: To evaluate incidence and predictors of local failure (LF) after radical cystectomy (RC) due to bladder cancer. METHODS: We focused on 1,112 patients treated with RC, between 1990 and 2012, at a single center. LF was defined as imaging evidence of recurrence in the pelvic soft tissues or nodes below the aortic bifurcation at least 3 months before the detection of distant metastases. Competing risk analyses tested the relationship between clinical and pathological factors and the risk to develop LF...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28887095/psychological-distress-in-patients-undergoing-surgery-for-urological-cancer-a-single-centre-cross-sectional-study
#13
Antonio Luigi Pastore, Ana Mir, Serena Maruccia, Giovanni Palleschi, Antonio Carbone, Cristina Lopez, Nuria Camps, Joan Palou
PURPOSE: Interest in the disease-specific psychological well-being of patients with cancer has increased, and it has been estimated that less than half of all patients with cancer are properly identified and subsequently treated for anxiety or depression. The aim of this study is to evaluate psychological distress in uro-oncological patients undergoing different surgeries: radical cystectomy, radical prostatectomy, radical nephrectomy, or transurethral resection (TUR) before the surgery...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28885656/bladder-cancer-to-patients-younger-than-30-years-a-retrospective-study-and-review-of-the-literature
#14
Ioannis Katafigiotis, Stavros Sfoungaristos, Alberto Martini, Konstantinos Stravodimos, Ioannis Anastasiou, Ioannis Mykoniatis, Mordechai Duvdevani, Constantinos Constantinides
OBJECTIVES: The aim of this report was to study the specific characteristics of bladder cancer in patients younger than 30 years. MATERIALS AND METHODS: Five patients with a mean age of 24 ± 2.83 years were included in the study. All patients had painless macroscopic hematuria as the first symptom. Three patients had pTa as a first diagnosis, one had pT1 and one pT2. All the patients had smoking as a risk factor and at least one additional possible risk factor...
September 5, 2017: Urologia
https://www.readbyqxmd.com/read/28882404/health-related-quality-of-life-following-radical-cystectomy-comparative-analysis-from-the-medicare-health-outcomes-study
#15
Brian R Winters, Jonathan L Wright, Sarah K Holt, Atreya Dash, John L Gore, George R Schade
PURPOSE: Health related quality of life (HRQOL) after radical cystectomy (RC) and ileal conduit is not well quantified at the population level. We evaluated HRQOL in patients with bladder cancer (BC) compared with non-cancer controls (NCC) and colorectal cancer (CRC) patients using SEER-Medicare Health Outcomes Survey (MHOS) data. MATERIALS AND METHODS: SEER-MHOS data (1998-2013) was used to identify patients with BC and CRC undergoing extirpative surgery with ileal conduit or colostomy creation...
September 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28881475/the-cancer-of-the-bladder-risk-assessment-cobra-score-estimating-mortality-after-radical-cystectomy
#16
Christopher J Welty, Thomas H Sanford, Jonathan L Wright, Peter R Carroll, Matthew R Cooperberg, Maxwell V Meng, Sima P Porten
BACKGROUND: Risk stratification of patients with urothelial carcinoma of the bladder (UCB) after cystectomy has important clinical and research implications. The authors assessed the relative effect of tumor stage and lymph node status on cancer-specific survival (CSS) after cystectomy and developed a simplified risk-assessment tool. METHODS: In total, 14,828 patients who underwent cystectomy with lymph node dissection for UCB were identified from the Surveillance, Epidemiology, and End Results database (1988-2011)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28879675/mir-199a-3p-and-mir-214-3p-improve-the-overall-survival-prediction-of-muscle-invasive-bladder-cancer-patients-after-radical-cystectomy
#17
Thorsten H Ecke, Katja Stier, Sabine Weickmann, Zhongwei Zhao, Laura Buckendahl, Carsten Stephan, Ergin Kilic, Klaus Jung
To improve the clinical decision-making regarding further treatment management and follow-up scheduling for patients with muscle-invasive bladder cancer (MIBC) after radical cystectomy (RC), a better prediction accuracy of prognosis for these patients is urgently needed. The objective of this study was to evaluate the validity of differentially expressed microRNAs (miRNAs) based on a previous study as prognostic markers for overall survival (OS) after RC in models combined with clinicopathological data. The expression of six miRNAs (miR-100-5p, miR-130b-3p, miR-141-3p, miR-199a-3p, miR-205-5p, and miR-214-3p) was measured by RT-qPCR in formalin-fixed, paraffin-embedded tissue samples from 156 MIBC patients who received RC in three urological centers...
September 6, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28878595/neoadjuvant-platinum-based-chemotherapy-is-an-independent-predictor-for-preoperative-thromboembolic-events-in-bladder-cancer-patients-undergoing-radical-cystectomy
#18
Cliodhna Browne, Niall F Davis, William J Nolan, Eoin D MacCraith, Gerald M Lennon, David W Mulvin, David J Galvin, David M Quinlan
INTRODUCTION: Neoadjuvant chemotherapy (NAC) confers a significant survival benefit in patients with muscle invasive bladder cancer. Platinum-based chemotherapy increases the risk of thromboembolic events (TEE). We determined the effect of cisplatin-based NAC on the incidence of preoperative TEEs in radical cystectomy patients. MATERIALS AND METHODS: A retrospective matched case-control study was performed on 55 patients undergoing radical cystectomy for muscle invasive bladder cancer...
August 2017: Current Urology
https://www.readbyqxmd.com/read/28875611/oncologic-outcomes-and-predictive-factors-for-recurrence-following-robot-assisted-radical-cystectomy-for-urothelial-carcinoma-multicenter-study-from-korea
#19
Ji Sung Shim, Tae Gyun Kwon, Koon Ho Rha, Young Goo Lee, Ji Youl Lee, Byong Chang Jeong, Jae Yoon Kim, Jong Hyun Pyun, Sung Gu Kang, Seok Ho Kang
The aim of our study was to evaluate intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns in a multicenter series of patients treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma (UC) of the bladder. Between 2007 and 2015, 346 patients underwent RARC at multiple tertiary referral centers in Korea. Descriptive statistics were used for demographics and perioperative variables. Survival and recurrence were estimated with Kaplan-Meier analysis...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28872778/effects-of-thiazolidinedione-in-patients-with-active-bladder-cancer
#20
Roger Li, Michael J Metcalfe, J E Ferguson Rd, Sharada Mokkapati, Graciela M Nogueras González, Colin P Dinney, Neema Navai, David J McConkey, Sunil K Sahai, Ashish M Kamat
OBJECTIVE: To examine the influence of perioperative thiazolidinedione (TZD) on cancer-specific outcomes in patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC). DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort of 173 diabetic patients undergoing RC from 2005 to 2010 was identified. Of those, 53 were on TZD treatment at the time of surgery, with 33 patients taking pioglitazone. Baseline clincopathologic characteristics, as well as cancer specific survival (CSS), recurrence free survival (RFS), and overall survival (OS) were compared between the patients on and off of TZD at the time of RC...
September 5, 2017: BJU International
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