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Radical cystectomy

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https://www.readbyqxmd.com/read/28447581/effect-of-cisplatin-based-neoadjuvant-chemotherapy-on-survival-in-patients-with-bladder-cancer-a-meta-analysis
#1
Gang Li, Hui-Min Niu, Hong-Tao Wu, Bao-Yu Lei, Xiao-Hua Wang, Xiao-Bo Guo, Shu-Lin Feng
PURPOSE: Cisplatin-based neoadjuvant chemotherapy (NAC) has been shown to improve survival in patients with muscle-invasive bladder cancer (MIBC) who underwent radical cystectomy as compared with patients who underwent surgery alone. It has also been suggested as current standard of care in surgically-fit patients with MIBC. This meta-analysis assessed the effect of cisplatin-based NAC on survival in patients with bladder cancer. SOURCE: PubMed, CENTRAL, and Embase were searched until November 22, 2016...
April 26, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28443141/finding-treatment-success-in-patients-unfit-for-radical-cystectomy
#2
Michael Leveridge
No abstract text is available yet for this article.
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28443140/chemoradiotherapy-in-octogenarians-as-primary-treatment-for-muscle-invasive-bladder-cancer
#3
Victor A McPherson, George Rodrigues, Glenn Bauman, Eric Winquist, Joseph Chin, Jonathan Izawa, Kylea Potvin, Scott Ernst, Varagur Venkatesan, Tracy Sexton, Belal Ahmad, Nicholas Power
INTRODUCTION: While radical cystectomy is the gold standard for muscle-invasive bladder cancer (MIBC), in octogenarians cystectomy results in a higher perioperative mortality rate (6.8-11.1%) than in younger patients (2.2%). Trimodality therapy is a bladder-sparing regimen composed of transurethral resection of bladder tumour (TURBT) and chemoradiotherapy, with intent for salvage cystectomy, and has a 62.5-90% initial complete response rate. In this study, we evaluate TURBT and chemoradiotherapy without salvage cystectomy in medically inoperable octogenarian patients...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28438212/primary-follicular-dendritic-cell-sarcoma-of-the-urinary-bladder-the-first-case-report-and-potential-diagnostic-pitfalls
#4
Guang-Jie Duan, You-Li Wu, Hui Sun, Lang Lang, Zhi-Wen Chen, Xiao-Chu Yan
BACKGROUND: Extranodal follicular dendritic cell sarcoma (FDCS) is a very rare malignancy with a variable clinical course. It is often not considered and has the potential to result in a misdiagnosis of other common sarcomas or sarcomatoid carcinomas. This is particularly true with the preoperative biopsy specimen, in which the tissue sample is often small. CASE PRESENTATION: A case of FDCS in a 63-year-old woman, arising in the urinary bladder, a previously unreported site, is described...
April 24, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28434947/effect-of-urinary-cytology-for-detecting-recurrence-in-remnant-urothelium-after-radical%C3%A2-cystectomy-insights-from-a-10-year-cytology-database
#5
Renate Pichler, Gennadi Tulchiner, Wilhelm Oberaigner, Georg Schaefer, Wolfgang Horninger, Andrea Brunner, Isabel Heidegger
BACKGROUND: We evaluated the diagnostic accuracy of urinary cytology (UCy) for detecting recurrence in the remnant urothelium (RRU) after radical cystectomy (RC) for urothelial cancer. PATIENTS AND METHODS: We conducted a 10-year retrospective analysis of a prospectively collected, single-center RC database comprising 177 patients who had undergone follow-up examinations at our department with ≥ 1 available postoperative UCy specimen. UCy specimens were classified using the Papanicolaou scheme...
March 30, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28434064/the-utility-of-ct-and-mri-in-detecting-male-urethral-recurrence-after-radical-cystectomy
#6
Jung Jae Park, Byung Kwan Park
PURPOSE: To evaluate the utility of computed tomography (CT) and magnetic resonance imaging (MRI) in detecting male urethral recurrence (UR). MATERIALS AND METHODS: Between December 2008 and March 2016, 12 men (age range 61-85 years; median, 74 years) with urethral bloody discharge or pain were histologically confirmed as UR after radical cystectomy due to urothelial carcinoma. Of these patients, eight underwent both CT and MRI. The remaining four patients underwent CT only...
April 22, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28433471/is-transurethral-resection-alone-enough-for-the-diagnosis-of-histological-variants-a-single-center-study
#7
Marco Moschini, Shahrokh F Shariat, Massimo Freschi, Francesco Soria, David D'Andrea, Mohammad Abufaraj, Beat Foerster, Paolo Dell'Oglio, Emanuele Zaffuto, Agostino Mattei, Andrea Salonia, Francesco Montorsi, Alberto Briganti, Andrea Gallina, Renzo Colombo
INTRODUCTION: To evaluate incidence of histological variants and grade agreement between transurethral resection (TUR) and radical cystectomy (RC) in patients with bladder cancer. METHODS: A total of 779 patients treated with TUR and subsequently with RC between 1990 and 2013 at a single center were analyzed retrospectively. Variant histology classifications used in our analyses were sarcomatoid, small cell, squamous, or micropapillary. Grade agreement was calculated using the Cohen kappa coefficient...
April 19, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28432572/micropapillary-bladder-cancer-a-clinico-pathological-characterization-and-treatment-analysis
#8
Z Li, H Liao, Z Tan, D Mao, Y Wu, Y M Xiao, S K Yang, L Zhong
PURPOSE: Micropapillary bladder cancer (MPBC) is a very rare and aggressive variant of urothelial carcinoma (UC). The aim of this study was to investigate the clinico-pathological characteristics, treatment, and prognosis of MPBC to improve the understanding of this invasive disease. METHODS: We reviewed the records of 6 patients with MPBC who were evaluated and treated at our hospital between 2009 and 2015, and additionally reviewed 38 cases reported in the literature...
April 21, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28420564/prognostic-role-of-neutrophil-to-lymphocyte-ratio-in-primary-non-muscle-invasive-bladder-cancer
#9
David D'Andrea, Marco Moschini, Kilian Gust, Mohammad Abufaraj, Mehmet Özsoy, Romain Mathieu, Francesco Soria, Alberto Briganti, Morgan Rouprêt, Pierre I Karakiewicz, Shahrokh F Shariat
INTRODUCTION: The purpose of this study was to assess the role of pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictor of clinical outcomes in patients treated with transurethral resection (TURB) for primary non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: Data from 918 patients treated with TURB for primary NMIBC were retrospectively collected. NLR was evaluated as binary variable with the cut-point of 3 based on the visual best correlation of the receiver operating curve analyses focusing on disease recurrence...
March 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28415929/retrospective-analysis-of-a-surgical-innovation-using-the-ideal-framework-radical-cystectomy-with-epidural-anaesthesia
#10
Holger Gerullis, Thorsten H Ecke, Dimitri Barski, Carsten Bantel, Andreas Weyland, Jens Uphoff, Thomas Jansen, Friedhelm Wawroschek, Alexander Winter
Objectives To retrospectively analyse experience of radical cystectomy using spinal/epidural anaesthesia and to classify this method using the IDEAL criteria. Methods Data from patients who had undergone radical cystectomy using spinal/epidural anaesthesia were evaluated retrospectively, focusing on clinical data, intraoperative and perioperative parameters and postoperative complications. Current literature reporting on this technique was reviewed and, together with the present study, evaluated according to the IDEAL recommendations...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28412065/comparative-effectiveness-of-trimodal-therapy-versus-radical-cystectomy-for-localized-muscle-invasive-urothelial-carcinoma-of-the-bladder
#11
Thomas Seisen, Maxine Sun, Stuart R Lipsitz, Firas Abdollah, Jeffrey J Leow, Mani Menon, Mark A Preston, Lauren C Harshman, Adam S Kibel, Paul L Nguyen, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
Given the lack of randomized evidence comparing trimodal therapy (TMT) to radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB), we performed an observational cohort study to examine the comparative effectiveness of these two definitive treatments. Within the National Cancer Data Base (2004-2011),we identified 1257 (9.8%) and 11 586 (90.2%) patients who received TMT and RC, respectively. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier analysis showed that median overall survival (OS) was similar between the TMT (40 mo, 95% confidence interval [CI] 34-46) and RC groups (43 mo 95% CI 41-45; p=0...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28412027/regionalization-of-radical-cystectomy-in-the-united-states
#12
Christopher B Anderson, Renee Gennarelli, Harry W Herr, Elena B Elkin
PURPOSE: Radical cystectomy (RC) has become increasingly regionalized to high-volume hospitals. Our objective was to describe changes in regional market concentration and the distribution of RCs among hospitals, and examine how these changes affect patient travel distance to surgery. MATERIALS AND METHODS: We used the surveillance, epidemiology, and end results-Medicare database to identify patients who had RC for bladder cancer from 2001 to 2011. We defined RC market concentration within each Hospital Referral Regions (HRR) in surveillance, epidemiology, and end results using the Hirschman-Herfindhal Index...
April 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28411100/w-pouch-with-modified-non-isolated-extra-limb-for-continence-in-cutaneous-diversion-after-radical-cystectomy
#13
Khaled M Abd Elwahab, Ahmed M Eliwa, Mohammed M Seleem, Maged M Ali, Islam M El-Babouly, Ahmed Ragab, Mohammed Naguib, Hamdy M Desouky, Esam A E Desoky, Mohammed Omran, Hussein M Kamel
OBJECTIVE: To report the functional results of continent cutaneous ileal urinary diversion using modified W-pouch with non-isolated extra limb for continence . PATIENTS & METHODS: From January 2013 to January 2016, 21 patients with muscle-invasive bladder cancer with with median (interquartile range) of 59 (56.5-62.5) years old underwent radical cystectomy with pelvic lymphadenectomy; they then had an ileal continent cutaneous pouch constructed from W-pouch with non-isolated extra limb for continence...
April 11, 2017: Urology
https://www.readbyqxmd.com/read/28410011/propensity-score-analysis-of-radical-cystectomy-versus-bladder-sparing-trimodal-therapy-in-the-setting-of-a-multidisciplinary-bladder-cancer-clinic
#14
Girish S Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J Bostrom, Cynthia Kuk, Kathy Li, Arnoud J Templeton, Srikala S Sridhar, Theodorus H van der Kwast, Peter Chung, Robert G Bristow, Michael Milosevic, Padraig Warde, Neil E Fleshner, Michael A S Jewett, Shaheena Bashir, Alexandre R Zlotta
Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder cancer (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care for muscle-invasive bladder cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection of bladder tumor, chemotherapy for radiation sensitization, and external beam radiotherapy has emerged as a valid treatment option. In the absence of randomized studies, this study compared the oncologic outcomes between patients treated with RC or TMT by using a propensity score matched-cohort analysis...
April 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28405873/erratum-to-robotic-radical-cystectomy-technical-tips-and-tricks
#15
S S Goonewardene, D M Bolton, N Lawrentschuk
No abstract text is available yet for this article.
April 12, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28403929/-conservative-placenta-percreta-management-using-uterine-arterial-embolization-procedure-a-series-of-12-cases
#16
C Hennetier, M Daudruy Brasseur, S Patrier, E Clavier, M L Thibault, E Verspyck
We report a retrospective series of 12 placentas percreta with bladder invasion and for which an expected initially multidisciplinary conservative surgical treatment associated with uterine artery embolization was programmed. Conservative surgical treatment was only performed in 7 women. Radical surgical treatment was necessary during the caesarean section and complicated by massive hemorrhage in three women and secondary in two other women for infectious diseases. Radical surgical treatment was associated with partial cystectomy complicated with urinary disorder sequelae in three women...
March 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28399521/neoadjuvant-chemotherapy-with-gemcitabine-plus-cisplatin-in-patients-with-locally-advanced-bladder-cancer
#17
Dora Niedersüss-Beke, Thomas Puntus, Thomas Kunit, Birgit Grünberger, Michael Lamche, Wolfgang Loidl, Reinhard Böhm, Nicole Kraischits, Stefan Kudlacek, Paul Schramek, Johannes G Meran
BACKGROUND: Neoadjuvant chemotherapy with methotrexate-vinblastine-doxorubicin-cisplatin (MVAC) is the standard of care for muscle-invasive urothelial bladder cancer. Gemcitabine plus cisplatin (GC) shows similar efficacy with less toxicity in the metastatic setting and has therefore often been used interchangeably with MVAC. We report on the efficacy and safety of neoadjuvant GC in patients with locally advanced urothelial cancer. MATERIALS AND METHODS: We prospectively evaluated 87 patients in 2 centers...
April 12, 2017: Oncology
https://www.readbyqxmd.com/read/28398951/challenges-in-pathologic-staging-of-bladder-cancer-proposals-for-fresh-approaches-of-assessing-pathologic-stage-in-light-of-recent-studies-and-observations-pertaining-to-bladder-histoanatomic-variances
#18
REVIEW
Gladell P Paner, Rodolfo Montironi, Mahul B Amin
The paradigm of pathologic stage (pT) categorization in bladder cancer remains the depth of invasion into the different histologic layers of the bladder wall. However, the approaches to assigning pT stage category toward an enhanced outcome stratification have been marked by challenges and innovations, due in part to our growing appreciation of the surprisingly perplexing bladder histoanatomy. Upstaging of pT1 tumors after radical cystectomy is substantial and underscores the potential value of pT1 substaging in transurethral resection (TUR) specimens...
May 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28397105/detecting-asymptomatic-recurrence-after-radical-cystectomy-contributes-to-better-prognosis-in-patients-with-muscle-invasive-bladder-cancer
#19
Ayumu Kusaka, Shingo Hatakeyama, Shogo Hosogoe, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Ken Fukushi, Takuma Narita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Chikara Ohyama
The prognostic benefit of oncological follow-up to detect asymptomatic recurrence after radical cystectomy (RC) remains unclear. We aimed to assess whether routine follow-up to detect asymptomatic recurrence after RC improves patient survival. We retrospectively analyzed 581 RC cases for muscle-invasive bladder cancer at four hospitals between May 1996 and February 2017. All patients had regular follow-up examinations with urine cytology, blood biochemical tests, and computed tomography after RC. We investigated the first site and date of tumor recurrence...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28396183/the-impact-of-health-literacy-and-clinicodemographic-factors-on-use-of-discharge-services-after-radical-cystectomy
#20
Stephen F Kappa, Kristen R Scarpato, Kathryn M Goggins, Sunil Kripalani, Kelvin A Moses
PURPOSE: There are few data regarding the relationship between health literacy and discharge disposition. We hypothesized that patient discharge needs after radical cystectomy (RC) are affected by health literacy. MATERIALS AND METHODS: We identified 504 patients who underwent RC and completed the validated Brief Health Literacy Screen (BHLS) since November 2010. Bivariate and logistic regression analyses were performed to determine if health literacy was associated with utilization of discharge resources after RC...
April 7, 2017: Journal of Urology
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