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Muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/29329898/-prognostic-of-older-age-for-patients-with-invasive-muscle-bladder-cancer-and-treated-by-radical-cystectomy
#1
Y Dehayni, M Tetou, Y Khdach, A Janane, M Alami, A Ameur
INTRODUCTION: Bladder tumor is a disease of older persons, but can also occur in young adults, because certainly an influence of environmental factors and a change of lifestyle. The aim of our retrospective analysis is to assess and evaluate the extent of the prognostic impact of age on the carcinological prognosis of invasive-muscle-bladder cancer treated by total cystotomy. METHODS: To evaluate the association of patient age with pathological characteristics and recurrence-free and disease survival, we retrospectively reviewed 345 patients with invasive bladder cancer between January 2000 and January 2015...
January 9, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29329894/neoadjuvant-dose-dense-mvac-versus-gc-in-patients-with-ct3-4an0m0-bladder-cancer-treated-with-radical-cystectomy
#2
Homayoun Zargar, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Trinity J Bivalacqua, Philippe E Spiess, Peter C Black, Wassim Kassouf
BACKGROUND: Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC. METHODS: We retrospectively reviewed records of patients with urothelial cancer who received NAC and underwent cystectomy at 20 contributing institutions from 2000-2015...
January 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29325739/anti-programmed-cell-death-1-ligand-1-pd-1-pd-l1-antibodies-for-the-treatment-of-urothelial-carcinoma-state-of-the-art-and-future-development
#3
REVIEW
Thomas Powles, Andrea Necchi, Galit Rosen, Subramanian Hariharan, Andrea B Apolo
Immunotherapy with programmed cell death 1/ligand 1 (PD-1/PD-L1) checkpoint inhibitors has expanded a previously limited pool of effective treatment options for patients with metastatic urothelial carcinoma, particularly those with recurring or refractory disease and those who are ineligible for cisplatin. This review reports key findings from completed and ongoing clinical trials that highlight the potential of PD-1/PD-L1 blockade in urothelial carcinoma. A literature search was performed of PubMed, Embase, ClinicalTrials...
December 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29323757/differentiation-associated-urothelial-cytochrome-p450-oxidoreductase-predicates-the-xenobiotic-metabolising-activity-of-luminal-muscle-invasive-bladder-cancers
#4
Simon C Baker, Volker M Arlt, Radek Indra, Madeleine Joel, Marie Stiborova, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H Phillips, Jennifer Southgate
Extra-hepatic metabolism of xenobiotics by epithelial tissues has evolved as a self-defence mechanism but has potential to contribute to the local activation of carcinogens. Bladder epithelium (urothelium) is bathed in excreted urinary toxicants and pro-carcinogens. This study reveals how differentiation affects cytochrome P450 (CYP) activity and the role of NADPH:P450 oxidoreductase (POR). CYP1A1 and CYP1B1 transcripts were inducible in normal human urothelial (NHU) cells maintained in both undifferentiated and functional barrier-forming differentiated states in vitro...
January 11, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29323062/role-of-p53-and-ki-67-immunomarkers-in-carcinoma-of-urinary-bladder
#5
Brijesh Thakur, Sanjeev Kishore, Kanika Dutta, Sanjay Kaushik, Aparna Bhardwaj
BACKGROUND: Urothelial carcinoma is common urinary malignancy responsible for a significant proportion of cancer morbidity and mortality. We carried out the present study to demonstrate the clinicohistopathological features and to correlate the p53 and Ki-67 immunoexpression with grade and stage of bladder carcinomas. MATERIALS AND METHODS: We investigated 110 cases of bladder tumor. Grading and staging were done according to the WHO-2004 and American Joint Committee on Cancer-TNM staging recommendations...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322799/predictors-and-prognostic-implications-of-clinical-decisions-in-patients-with-primary-high-risk-non-muscle-invasive-bladder-cancer-results-of-a-cross-country-retrospective-study
#6
S Poletajew, R Biernacki, P Buraczynski, J Chojnacki, S Czarniecki, D Gajewska, T Pohaba, J Sondka-Migdalska, M Skrzypczyk, T Suchojad, D Wojtkowiak, B Zaforemski, L Zapala, A Zemla, P Radziszewski
Adjuvant diagnostic and therapeutic procedures are available to reduce the risk of recurrence or progression in patients with high-risk non-muscle-invasive bladder cancer (NMIBC). However, their indications and efficacy remain a matter of debate. The aim of this study was to analyze therapeutic decisions in patients with primary high-risk NMIBC and to analyze the adherence to clinical guidelines in this field.545 consecutive patients, aged a median of 70.3 years, diagnosed with primary high-risk NMIBC in thirteen urological institutions, were enrolled into this retrospective study...
2018: Neoplasma
https://www.readbyqxmd.com/read/29319922/the-effect-of-timing-of-an-immediate-instillation-with-mitomycin-c-after-transurethral-resection-in-941-non-muscle-invasive-bladder-cancer-patients
#7
Judith Bosschieter, R Jeroen A van Moorselaar, André N Vis, Tessa van Ginkel, Birgit I Lissenberg-Witte, Goedele M A Beckers, Jakko A Nieuwenhuijzen
OBJECTIVES: To investigate whether timing of an immediate instillation (on the day of transurethral resection or one day later) has impact on time to recurrence of non-muscle-invasive bladder cancer. PATIENTS AND METHODS: All patients with non-muscle-invasive bladder cancer who were enrolled in a prospective trial between 1998 and 2003 and treated with an early mitomycin C instillation (on the day of transurethral resection or one day later), were selected. Statistical analysis was performed with Kaplan-Meier curves and multivariable Cox regression...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29319482/perioperative-chemotherapy-for-bladder-cancer-a-qualitative-study-of-physician-knowledge-attitudes-and-behaviour
#8
Melanie Walker, R Christopher Doiron, Simon D French, Deb Feldman-Stewart, D Robert Siemens, William J Mackillop, Christopher M Booth
INTRODUCTION: Use of chemotherapy for muscle-invasive bladder cancer (MIBC) is known to be low. To understand factors driving practice we use the Theoretical Domains Framework (TDF) to identify barriers and enablers of chemotherapy use. METHODS: A convenience sample of Canadian urologists, medical oncologists (MOs) and radiation oncologists (ROs) participated in individual, semi-structured, one-hour telephone interviews. An interview guide was developed using the TDF to assess potential barriers and enablers of chemotherapy use...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29316106/robotic-assisted-radical-cystectomy-with-intracorporeal-urinary-diversion-versus-open-early-australian-experience
#9
Ken Chow, Homayoun Zargar, Niall M Corcoran, Anthony J Costello, Justin S Peters, Philip Dundee
BACKGROUND: The aim of this study was to describe our initial Australian single surgeon experience with robotic-assisted radical cystectomy (RARC) and intracorporeal urinary diversion (ICUD) and to compare the outcomes with open radical cystectomy (ORC). METHODS: Between January 2014 and June 2016, consecutive patients diagnosed with muscle invasive and high-risk non-muscle invasive bladder cancer undergoing radical cystectomy were included. Treatment modalities included either RARC with ICUD or ORC...
January 8, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29313114/bladder-cancer-local-staging-multiparametric-mri-performance-following-transurethral-resection
#10
Christian B van der Pol, Atul B Shinagare, Sree Harsha Tirumani, Mark A Preston, Mark G Vangel, Stuart G Silverman
PURPOSE: To evaluate the performance of multiparametric MRI (mpMRI) for the local staging of bladder cancer following transurethral resection of bladder tumor. METHODS: This Institutional Review Board-approved, retrospective study identified 45 patients with pathology-proven bladder cancer who underwent transurethral resection followed by mpMRI between August 2011 and October 2016. Two radiologists reviewed each MRI independently and assigned T and N stage. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for the presence of muscle invasion (T2 or higher), peri-vesical invasion (T3 or higher), and regional nodal disease compared to findings at cystectomy as the reference standard...
January 9, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29310182/re-increasing-age-is-not-associated-with-toxicity-leading-to-discontinuation-of-treatment-in-patients-with-urothelial-non-muscle-invasive-bladder-cancer-randomised-to-receive-3-years-of-maintenance-bacille-calmette-gu%C3%A3-rin-results-from-european-organisation
#11
https://www.readbyqxmd.com/read/29307686/purified-protein-derivative-skin-test-prior-to-bacillus-calmette-gu%C3%A3-rin-therapy-may-have-therapeutic-impact-in-patients-with-non-muscle-invasive-bladder-cancer
#12
Naoya Niwa, Eiji Kikuchi, Kazuhiro Matsumoto, Takeo Kosaka, Ryuichi Mizuno, Mototsugu Oya
PURPOSE: To investigate the clinical impact of the purified protein derivative (PPD) skin test prior to bacillus Calmette-Guérin (BCG) therapy in patients with non-muscle-invasive bladder cancer (NMIBC) treated with adjuvant BCG therapy. MATERIALS AND METHODS: A total of 498 NMIBC patients treated with adjuvant BCG therapy were included, among which 320 received the PPD skin test 1 to 2 weeks prior to BCG therapy. Oncological outcomes and the rate of BCG-related side effects were statistically evaluated...
January 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29306498/concurrent-chemoradiotherapy-for-bladder-cancer-practice-patterns-and-outcomes-in-the-general-population
#13
Ketan Ghate, Kelly Brennan, Safiya Karim, D Robert Siemens, William J Mackillop, Christopher M Booth
BACKGROUND: Clinical trials have shown that chemoradiotherapy (CRT) improves survival compared to radiation therapy (RT) alone in muscle-invasive bladder cancer. We describe uptake of CRT and comparative effectiveness in routine practice. METHODS: Electronic treatment records were linked to the population-based Ontario Cancer Registry to identify all patients with bladder cancer treated with curative-intent RT in 1999-2013. Modified Poisson regression was used to analyze factors associated with use of CRT...
January 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29305205/associations-between-travel-distance-hospital-volume-and-outcomes-following-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#14
Leilei Xia, Benjamin L Taylor, Ronac Mamtani, John P Christodouleas, Thomas J Guzzo
OBJECTIVE: To explore the associations between travel distance, hospital volume, and outcomes following radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) METHODS: The 2006 to 2013 National Cancer Database (NCDB) was queried to identify patients with MIBC who underwent RC. Multivariable regressions alternately including travel distance, hospital volume, and both in the models were used. Travel distances and hospital volumes were categorized by quartiles. Outcomes of interest were overall survival and quality-of-care indicators...
January 2, 2018: Urology
https://www.readbyqxmd.com/read/29297169/clinical-decision-making-in-surveillance-of-non-muscle-invasive-bladder-cancer-the-evolving-roles-of-urinary-cytology-and-molecular-markers
#15
Tahlita C M Zuiverloon, Florus C de Jong, Dan Theodorescu
Cystoscopy and urine cytology are the gold-standard tests for detection of recurrent disease during follow-up in patients with a history of non-muscle-invasive bladder cancer (NMIBC). High associated costs, as well as side effects, have driven the desire for inexpensive, noninvasive, accurate, and easy-to-use urine markers to detect bladder cancer recurrence. While many urine markers have been developed, very few have been clinically implemented. In this article, we discuss the requirements for development and validation of urine markers and the factors that hamper their clinical implementation...
December 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/29289519/contemporary-patterns-of-multidisciplinary-care-in-patients-with-muscle-invasive-bladder-cancer
#16
Lauren C Harshman, Abhishek Tripathi, Matthew Kaag, Jason A Efstathiou, Andrea B Apolo, Jean H Hoffman-Censits, Walter M Stadler, Evan Y Yu, Bernard H Bochner, Eila C Skinner, Tracy Downs, Anne E Kiltie, Dean F Bajorin, Khurshid Guru, William U Shipley, Gary D Steinberg, Noah M Hahn, Srikala S Sridhar
BACKGROUND: Multidisciplinary clinics integrate the expertise of several specialties to provide effective treatment to patients. This exposure is especially relevant in the management of muscle-invasive bladder cancer (MIBC), which requires critical input from urology, radiation oncology, and medical oncology, among other supportive specialties. MATERIALS AND METHODS: In the present study, we sought to catalog the different styles of multidisciplinary care models used in the management of MIBC and to identify barriers to their implementation...
December 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29288007/overexpression-of-semaphorin-3a-in-patients-with-urothelial-cancer
#17
Zahava Vadasz, Jacob Rubinstein, Jacob Bejar, Hilla Sheffer, Sarel Halachmi
OBJECTIVE: A highly sensitive and specific urine marker for the detection of recurrent urothelial cancer and for screening healthy population or people at risk for urothelial cancer has not been found yet. As urine cytology is not sensitive enough, patients with non-muscle-invasive bladder cancer need lifelong follow-up involving multiple invasive cystoscopies. Our aims of study were to examine the expression of semaphorin 3A in urothelial cancer patients and to evaluate semaphorin 3A as a potential marker for urothelial cancer...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29288006/advancements-in-optical-techniques-and-imaging-in-the-diagnosis-and-management-of-bladder-cancer
#18
REVIEW
Tracy L Rose, Yair Lotan
Accurate detection and staging is critical to the appropriate management of urothelial cancer (UC). The use of advanced optical techniques during cystoscopy is becoming more widespread to prevent recurrent nonmuscle invasive bladder cancer. Standard of care for muscle-invasive UC includes the use of computed tomography and/or magnetic resonance imaging, but staging accuracy of these tests remains imperfect. Novel imaging modalities are being developed to improve current test performance. Positron emission tomography/computed tomography has a role in the initial evaluation of select patients with muscle-invasive bladder cancer and in disease recurrence in some cases...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29286018/miliary-pulmonary-infection-after-bcg-intravesical-instillation-a-rare-misdiagnosed-and-mistreated-complication
#19
Giorgio Calleris, Giancarlo Marra, Silvia Corcione, Marco Oderda, Chiara Cardellino, Sabrina Audagnotto, Bruno Frea, Francesco Giuseppe De Rosa, Paolo Gontero
Intravesical Bacillus Calmette-Guérin (BCG) immunotherapy decreases the progression risk of non-muscle-invasive bladder cancer, but potentially yields a broad spectrum of side effects. We report the case of a 73-year-old man affected by miliary pulmonary BCG infection, whose microbiological diagnosis was probably hindered by empiric fluoroquinolones, focusing on imaging and clinical work-up.
December 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/29284232/chromium-in-urothelial-carcinoma-of-the-bladder
#20
Tomasz Golabek, Katarzyna Socha, Jacek Kudelski, Barbara Darewicz, Renata Markiewicz-Zukowska, Piotr Chlosta, Maria Borawska
INTRODUCTION AND OBJECTIVES: Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, the involvement of heavy metals in tumourigenesis of urothelial carcinoma of the bladder has been poorly investigated. Therefore, the aim of this study was to examine the relationship between chromium (Cr) and bladder cancer. MATERIAL AND METHODS: Chromium concentration in two 36-sample series of bladder cancer tissue and sera from patients with this neoplasm were matched with those of a control group...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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