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Muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/28423532/implication-of-vascular-endothelial-growth-factor-a-and-c-in-revealing-diagnostic-lymphangiogenic-markers-in-node-positive-bladder-cancer
#1
Cédric Poyet, Linto Thomas, Tobias M Benoit, David Aquino Delmo, Laura Luberto, Irina Banzola, Michèle S Günthart, Giovanni Sais, Daniel Eberli, Tullio Sulser, Maurizio Provenzano
Several lymphangiogenic factors, such as vascular endothelial growth factors (VEGFs), have been found to drive the development of lymphatic metastasis in bladder cancer (BCa).Here, we have analyzed the gene expression of lymphangiogenic factors in tissue specimens from 12 non-muscle invasive bladder cancers (NMIBC) and 11 muscle invasive bladder cancers (MIBC), considering tumor and tumor-adjacent normal bladder areas obtained from the same organs. We then compared the results observed in patients with those obtained after treating human primary bladder microvascular endothelial cells (MEC) with either direct stimulation with VEGF-A or VEGF-C or by co-culturing (trans-well assay) MEC with bladder cancer cell lines varying in VEGF-A and VEGF-C production based on tumor grade...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423359/epithelial-mesenchymal-transition-induced-by-gro-%C3%AE-cxcr2-promotes-bladder-cancer-recurrence-after-intravesical-chemotherapy
#2
Lu Chen, Xiu-Wu Pan, Hai Huang, Yi Gao, Qi-Wei Yang, Lin-Hui Wang, Xin-Gang Cui, Dan-Feng Xu
Non-muscle invasive bladder cancers (NMIBC) are typically treated by transurethral resection with intravesical chemotherapy. However, the post-therapeutic incidence of tumor recurrence and progression to muscle invasive disease is high, and the underlying mechanism(s) remains unknown. In this study, we observed that recurrent bladder cancer cells exhibit a mesenchymal phenotype, which is initiated by the autocrine GRO-α signaling. Mechanically, the chemotherapeutic drug epidoxorubicin induces GRO-α expression in primary bladder cancer cells at G1/S phase via p38-dependent activation of NF-κB...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422550/evaluation-of-the-diagnostic-accuracy-of-ubc-%C3%A2-rapid-in-bladder-cancer-a-swedish-multicentre-study
#3
Johan Styrke, Helene Henriksson, Börje Ljungberg, Mudhar Hasan, Ingrid Silfverberg, Roland Einarsson, Per-Uno Malmström, Amir Sherif
OBJECTIVE: The aim of this study was to determine the diagnostic accuracy of UBC(®) Rapid - a urine-based marker for bladder cancer - in patients with bladder cancer and controls, and to compare the test results across risk groups. MATERIALS AND METHODS: This prospective phase II study was conducted at four Swedish hospitals. UBC Rapid was evaluated in four groups: A, newly diagnosed bladder cancer (n = 94); B, follow-up of non-muscle-invasive bladder cancer (n = 75); C, benign urinary tract diseases (n = 51); and D, healthy controls (n = 50)...
April 19, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28421294/a-prospective-comparison-of-intra-arterial-chemotherapy-combined-with-intravesical-chemotherapy-and-intravesical-chemotherapy-alone-after-transurethral-resection-with-a-thulium-laser-in-high-risk-non-muscle-invasive-bladder-cancer
#4
Feng Sun, Ruizhe Zhao, Yiyong Zhu, Di Cui, Xiaohai Wang, Bangmin Han, Shengjie Liang, Haitao Liu, Xiaowen Sun, Fujun Zhao, Dongliang Xu, Shujie Xia
Objective To compare intra-arterial chemotherapy combined with intravesical chemotherapy with intravesical chemotherapy alone in the treatment of high-risk non-muscle invasive bladder cancer (HRBC) after thulium laser resection of a bladder tumor (TmLRBT). MATERIALS AND METHODS: From January 2009 to December 2013, 283 patients with HRBC were randomly assigned to the combined group (group A, n = 141) or intravesical chemotherapy-alone group (group B, n = 142) after TmLRBT. Intra-arterial chemotherapy was administered after initial TmLRBT, with 3 courses at 4-week intervals...
April 18, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28420564/prognostic-role-of-neutrophil-to-lymphocyte-ratio-in-primary-non-muscle-invasive-bladder-cancer
#5
David D'Andrea, Marco Moschini, Kilian Gust, Mohammad Abufaraj, Mehmet Özsoy, Romain Mathieu, Francesco Soria, Alberto Briganti, Morgan Rouprêt, Pierre I Karakiewicz, Shahrokh F Shariat
INTRODUCTION: The purpose of this study was to assess the role of pretreatment neutrophil-to-lymphocyte ratio (NLR) as a predictor of clinical outcomes in patients treated with transurethral resection (TURB) for primary non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: Data from 918 patients treated with TURB for primary NMIBC were retrospectively collected. NLR was evaluated as binary variable with the cut-point of 3 based on the visual best correlation of the receiver operating curve analyses focusing on disease recurrence...
March 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28415801/identification-of-long-non-coding-rnas-that-stimulate-cell-survival-in-bladder-cancer
#6
Aleksandra M Dudek, Sabrina J Boer, Nanda Boon, J Alfred Witjes, Lambertus A L M Kiemeney, Gerald W Verhaegh
For many years, research on the biology underlying bladder cancer focused on protein-coding genes which cover only about 3% of the human genome. Recently, it was discovered that a large part of the human genome is actively transcribed as long non-coding RNAs (lncRNAs). LncRNAs are master regulators of gene expression and several lncRNAs were shown to play a role in bladder cancer development and progression. Here, we analyzed lncRNA expression in muscle-invasive bladder cancer (MIBC) using the MiTranscriptome database of cancer lncRNA expression profiles, and we studied their function in bladder cancer-derived tumor cells...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28412065/comparative-effectiveness-of-trimodal-therapy-versus-radical-cystectomy-for-localized-muscle-invasive-urothelial-carcinoma-of-the-bladder
#7
Thomas Seisen, Maxine Sun, Stuart R Lipsitz, Firas Abdollah, Jeffrey J Leow, Mani Menon, Mark A Preston, Lauren C Harshman, Adam S Kibel, Paul L Nguyen, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
Given the lack of randomized evidence comparing trimodal therapy (TMT) to radical cystectomy (RC) for muscle-invasive urothelial carcinoma of the bladder (UCB), we performed an observational cohort study to examine the comparative effectiveness of these two definitive treatments. Within the National Cancer Data Base (2004-2011),we identified 1257 (9.8%) and 11 586 (90.2%) patients who received TMT and RC, respectively. Inverse probability of treatment weighting (IPTW)-adjusted Kaplan-Meier analysis showed that median overall survival (OS) was similar between the TMT (40 mo, 95% confidence interval [CI] 34-46) and RC groups (43 mo 95% CI 41-45; p=0...
April 12, 2017: European Urology
https://www.readbyqxmd.com/read/28411100/w-pouch-with-modified-non-isolated-extra-limb-for-continence-in-cutaneous-diversion-after-radical-cystectomy
#8
Khaled M Abd Elwahab, Ahmed M Eliwa, Mohammed M Seleem, Maged M Ali, Islam M El-Babouly, Ahmed Ragab, Mohammed Naguib, Hamdy M Desouky, Esam A E Desoky, Mohammed Omran, Hussein M Kamel
OBJECTIVE: To report the functional results of continent cutaneous ileal urinary diversion using modified W-pouch with non-isolated extra limb for continence . PATIENTS & METHODS: From January 2013 to January 2016, 21 patients with muscle-invasive bladder cancer with with median (interquartile range) of 59 (56.5-62.5) years old underwent radical cystectomy with pelvic lymphadenectomy; they then had an ileal continent cutaneous pouch constructed from W-pouch with non-isolated extra limb for continence...
April 11, 2017: Urology
https://www.readbyqxmd.com/read/28410909/neoadjuvant-chemotherapy-in-elderly-patients-with-bladder-cancer-oncologic-outcomes-from-a-single-institution-experience
#9
Andrew R Leone, Kamran Zargar-Shoshtari, Gregory J Diorio, Pranav Sharma, David Boulware, Scott M Gilbert, Julio M Powsang, Jingsong Zhang, Wade J Sexton, Philippe E Spiess, Michael A Poch
INTRODUCTION: We conducted this study to determine if, in appropriately selected elderly patients receiving neoadjuvant chemotherapy (NAC), clinical outcomes including pathologic complete response/downstaging and overall survival were similar to a younger cohort. METHODS: Chart review was performed on patients receiving NAC for urothelial carcinoma of the bladder (UCB) from 2004 to 2013. A total of 116 patients were identified that underwent NAC from 2004 to 2013 for ≥ cT2N0M0 UCB...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28410011/propensity-score-analysis-of-radical-cystectomy-versus-bladder-sparing-trimodal-therapy-in-the-setting-of-a-multidisciplinary-bladder-cancer-clinic
#10
Girish S Kulkarni, Thomas Hermanns, Yanliang Wei, Bimal Bhindi, Raj Satkunasivam, Paul Athanasopoulos, Peter J Bostrom, Cynthia Kuk, Kathy Li, Arnoud J Templeton, Srikala S Sridhar, Theodorus H van der Kwast, Peter Chung, Robert G Bristow, Michael Milosevic, Padraig Warde, Neil E Fleshner, Michael A S Jewett, Shaheena Bashir, Alexandre R Zlotta
Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder cancer (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care for muscle-invasive bladder cancer (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection of bladder tumor, chemotherapy for radiation sensitization, and external beam radiotherapy has emerged as a valid treatment option. In the absence of randomized studies, this study compared the oncologic outcomes between patients treated with RC or TMT by using a propensity score matched-cohort analysis...
April 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28408175/an-oncofetal-glycosaminoglycan-modification-provides-therapeutic-access-to-cisplatin-resistant-bladder-cancer
#11
Roland Seiler, Htoo Zarni Oo, Davide Tortora, Thomas M Clausen, Chris K Wang, Gunjan Kumar, Marina Ayres Pereira, Maj S Ørum-Madsen, Mette Ø Agerbæk, Tobias Gustavsson, Mie A Nordmaj, Jamie R Rich, Nada Lallous, Ladan Fazli, Sherry S Lee, James Douglas, Tilman Todenhöfer, Shaghayegh Esfandnia, Dulguun Battsogt, John S Babcook, Nader Al-Nakouzi, Simon J Crabb, Igor Moskalev, Bernhard Kiss, Elai Davicioni, George N Thalmann, Paul S Rennie, Peter C Black, Ali Salanti, Mads Daugaard
BACKGROUND: Although cisplatin-based neoadjuvant chemotherapy (NAC) improves survival of unselected patients with muscle-invasive bladder cancer (MIBC), only a minority responds to therapy and chemoresistance remains a major challenge in this disease setting. OBJECTIVE: To investigate the clinical significance of oncofetal chondroitin sulfate (ofCS) glycosaminoglycan chains in cisplatin-resistant MIBC and to evaluate these as targets for second-line therapy. DESIGN, SETTING, AND PARTICIPANTS: An ofCS-binding recombinant VAR2CSA protein derived from the malaria parasite Plasmodium falciparum (rVAR2) was used as an in situ, in vitro, and in vivo ofCS-targeting reagent in cisplatin-resistant MIBC...
April 10, 2017: European Urology
https://www.readbyqxmd.com/read/28406993/topical-and-systemic-immunoreaction-triggered-by-intravesical-chemotherapy-in-an-n-butyl-n-4-hydroxybutyl-nitorosamine-induced-bladder-cancer-mouse-model
#12
Shunta Hori, Makito Miyake, Yoshihiro Tatsumi, Sayuri Onishi, Yosuke Morizawa, Yasushi Nakai, Nobumichi Tanaka, Kiyohide Fujimoto
Intravesical bacillus Calmette-Guerin (BCG) treatment is the most common therapy to prevent progression and recurrence of non-muscle invasive bladder cancer (NMIBC). Although the immunoreaction elicited by BCG treatment is well documented, those induced by intravesical treatment with chemotherapeutic agents are much less known. We investigated the immunological profiles caused by mitomycin C, gemcitabine, adriamycin and docetaxel in the N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced orthotopic bladder cancer mouse model...
2017: PloS One
https://www.readbyqxmd.com/read/28406148/bladder-cancer
#13
REVIEW
Oner Sanli, Jakub Dobruch, Margaret A Knowles, Maximilian Burger, Mehrdad Alemozaffar, Matthew E Nielsen, Yair Lotan
Bladder cancer is a highly prevalent disease and is associated with substantial morbidity, mortality and cost. Environmental or occupational exposures to carcinogens, especially tobacco, are the main risk factors for bladder cancer. Most bladder cancers are diagnosed after patients present with macroscopic haematuria, and cases are confirmed after transurethral resection of bladder tumour (TURBT), which also serves as the first stage of treatment. Bladder cancer develops via two distinct pathways, giving rise to non-muscle-invasive papillary tumours and non-papillary (solid) muscle-invasive tumours...
April 13, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28405683/bladder-intracavitary-hyperthermic-perfusion-chemotherapy-for-the-prevention-of-recurrence-of-non-muscle-invasive-bladder-cancer-after-transurethral-resection
#14
Mingchen Ba, Shuzhong Cui, Bin Wang, Hui Long, Zhaofei Yan, Shuai Wang, Yinbing Wu, Yuanfeng Gong
Preventing the recurrence of non-muscle invasive bladder cancer (NMIBC) post-transurethral resection (TUR) remains challenging. The aim of the present study was to investigate the effectiveness and safety of bladder intracavitary hyperthermic perfusion chemotherapy (BHPC) for prevention of NMIBC recurrence post-TUR. Between December 2006 and December 2014, 53 patients with NMIBC who underwent TUR were randomly assigned to receive BHPC (BHPC group, 28 patients) or intravesical chemotherapy alone (chemotherapy group, 25 patients) at the Intracelom Hyperthermic Perfusion Therapy Center of Guangzhou Medical University Cancer Hospital (Guangzhou, China)...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28403596/blue-light-cystoscopy-with-hexylaminolevulinate-our-7-years-experience
#15
Vito Lacetera, Ubaldo Cantoro, Lorenzo Montesi, Daniele Cantoro, Bernardo Cervelli, Antonio Cicetti, Giuliana Gabrielloni, Domenico Milella, Michele Montesi, Roberto Morcellini, Gianni Parri, Emilio Recanatini, Valerio Beatrici
AIM: The objective of the present study is to evaluate the diagnostic accuracy of hexylaminolevulinate (HAL) blue light cystoscopy compared with standard white light cystoscopy (WLC) in daily practice. MATERIALS AND METHODS: An observational, comparative, controlled (within patient) study was carried out at our Center. 61 consecutive patients with suspected or confirmed bladder cancer were recruited for the study from January 2008 until January 2015. Patients with suspected bladder cancer (positive cytology with negative WLC) or history of previous high-grade NMIBC or CIS were included in the study...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28400426/a-gene-signature-for-selecting-benefit-from-hypoxia-modification-of-radiotherapy-for-high-risk-bladder-cancer-patients
#16
Lingjian Yang, Janet Taylor, Amanda Eustace, Joely Irlam, Helen Denley, Peter J Hoskin, Jan Alsner, Francesca M Buffa, Adrian L Harris, Ananya Choudhury, Catharine M L West
Hypoxia modification improves overall survival in muscle invasive bladder cancer patients who undergo radiotherapy. There is evidence that hypoxic tumors benefit most from hypoxia modification. The study aimed to identify or derive a hypoxia gene signature that predicts benefit from hypoxia-modifying treatment in bladder cancer.<br /><br />Experimental Design: Published hypoxia signatures were tested and a new one derived by analyzing bladder cancer transcriptomic data from public databases. Tumor samples were available from the BCON phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON)...
April 11, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28399521/neoadjuvant-chemotherapy-with-gemcitabine-plus-cisplatin-in-patients-with-locally-advanced-bladder-cancer
#17
Dora Niedersüss-Beke, Thomas Puntus, Thomas Kunit, Birgit Grünberger, Michael Lamche, Wolfgang Loidl, Reinhard Böhm, Nicole Kraischits, Stefan Kudlacek, Paul Schramek, Johannes G Meran
BACKGROUND: Neoadjuvant chemotherapy with methotrexate-vinblastine-doxorubicin-cisplatin (MVAC) is the standard of care for muscle-invasive urothelial bladder cancer. Gemcitabine plus cisplatin (GC) shows similar efficacy with less toxicity in the metastatic setting and has therefore often been used interchangeably with MVAC. We report on the efficacy and safety of neoadjuvant GC in patients with locally advanced urothelial cancer. MATERIALS AND METHODS: We prospectively evaluated 87 patients in 2 centers...
April 12, 2017: Oncology
https://www.readbyqxmd.com/read/28398951/challenges-in-pathologic-staging-of-bladder-cancer-proposals-for-fresh-approaches-of-assessing-pathologic-stage-in-light-of-recent-studies-and-observations-pertaining-to-bladder-histoanatomic-variances
#18
REVIEW
Gladell P Paner, Rodolfo Montironi, Mahul B Amin
The paradigm of pathologic stage (pT) categorization in bladder cancer remains the depth of invasion into the different histologic layers of the bladder wall. However, the approaches to assigning pT stage category toward an enhanced outcome stratification have been marked by challenges and innovations, due in part to our growing appreciation of the surprisingly perplexing bladder histoanatomy. Upstaging of pT1 tumors after radical cystectomy is substantial and underscores the potential value of pT1 substaging in transurethral resection (TUR) specimens...
May 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28398114/voided-urine-versus-bladder-washing-cytology-for-detection-of-urothelial-carcinoma-which-is-better
#19
Anna Krarup Keller, Jørgen Bjerggaard Jensen
OBJECTIVE: Cytology is recommended as part of the follow-up of high-grade non-muscle-invasive bladder cancer (NMIBC). However, currently there are no solid guideline recommendations regarding the use of voided urine versus bladder washing for cytology as part of the diagnosis or follow-up of NMIBC. The aim of this study was to investigate whether the cytological outcome was equal regarding the two techniques. MATERIALS AND METHODS: The authors reviewed all outpatient flexible cystoscopies carried out in their department in 2013...
April 11, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28397105/detecting-asymptomatic-recurrence-after-radical-cystectomy-contributes-to-better-prognosis-in-patients-with-muscle-invasive-bladder-cancer
#20
Ayumu Kusaka, Shingo Hatakeyama, Shogo Hosogoe, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Ken Fukushi, Takuma Narita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Chikara Ohyama
The prognostic benefit of oncological follow-up to detect asymptomatic recurrence after radical cystectomy (RC) remains unclear. We aimed to assess whether routine follow-up to detect asymptomatic recurrence after RC improves patient survival. We retrospectively analyzed 581 RC cases for muscle-invasive bladder cancer at four hospitals between May 1996 and February 2017. All patients had regular follow-up examinations with urine cytology, blood biochemical tests, and computed tomography after RC. We investigated the first site and date of tumor recurrence...
May 2017: Medical Oncology
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