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Muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/28319171/a-reported-20-gene-expression-signature-to-predict-lymph-node-positive-disease-at-radical-cystectomy-for-muscle-invasive-bladder-cancer-is-clinically-not-applicable
#1
Kim E M van Kessel, Harmen J G van de Werken, Irene Lurkin, Angelique C J Ziel-van der Made, Ellen C Zwarthoff, Joost L Boormans
BACKGROUND: Neoadjuvant chemotherapy (NAC) for muscle-invasive bladder cancer (MIBC) provides a small but significant survival benefit. Nevertheless, controversies on applying NAC remain because the limited benefit must be weight against chemotherapy-related toxicity and the delay of definitive local treatment. Therefore, there is a clear clinical need for tools to guide treatment decisions on NAC in MIBC. Here, we aimed to validate a previously reported 20-gene expression signature that predicted lymph node-positive disease at radical cystectomy in clinically node-negative MIBC patients, which would be a justification for upfront chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28314306/expression-of-indoleamine-2-3-dioxygenase-gene-is-a-feature-of-poorly-differentiated-non-muscle-invasive-urothelial-cell-bladder-carcinomas
#2
Tvrtko Hudolin, Chantal Mengus, Julie Coulot, Zeljko Kastelan, Ahmad El-Saleh, Giulio C Spagnoli
AIM: To evaluate indoleamine 2,3-dioxygenase (IDO) gene expression in non-muscle-invasive urothelial cell bladder carcinoma (NMIBC). PATIENTS AND METHODS: Seventy-four patients undergoing surgical treatment for NMIBC were enrolled in the study. IDO gene expression was assessed by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: IDO gene expression was detectable significantly more frequently (48/74, 64.86% vs. 5/21, 23...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28293425/podocalyxin-like-and-rna-binding-motif-protein-3-are-prognostic-biomarkers-in-urothelial-bladder-cancer-a-validatory-study
#3
Karolina Boman, Gustav Andersson, Christoffer Wennersten, Björn Nodin, Göran Ahlgren, Karin Jirström
BACKGROUND: Urothelial bladder cancer (UBC) is a disease that often is discovered when the tumour is non-muscle invasive, i.e. in Ta or T1 stage. Some patients will progress into muscle-invasive disease, a potentially deadly condition. Although there are some prognostic models, the need for prognostic and predictive biomarkers is considerate and urgent. Membranous expression of podocalyxin-like protein 1 (PODXL) and low expression of the RNA-binding motif 3 (RBM3) has previously been shown to be associated with an aggressive tumour phenotype and poor prognosis in several forms of cancer, including UBC...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28291636/correlation-between-messenger-rna-expression-and-protein-expression-of-immune-checkpoint-associated-molecules-in-bladder-urothelial-carcinoma-a-retrospective-study
#4
Constance Le Goux, Diane Damotte, Sophie Vacher, Mathilde Sibony, Nicolas Barry Delongchamps, Anne Schnitzler, Benoit Terris, Marc Zerbib, Ivan Bieche, Géraldine Pignot
OBJECTIVES: Immunotherapy for bladder cancer seems to have promising results. Here, we evaluated the association between messenger RNA (mRNA) and protein levels and possible prognostic value of the programmed cell death 1/programmed cell death ligand 1 (PD-1/PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) immune checkpoint pathways during bladder carcinogenesis. METHODS AND MATERIALS: Tumor samples were obtained from 155 patients (84 with muscle-invasive bladder cancer [MIBC], and 71 non-muscle-invasive bladder cancer [NMIBC]) and normal bladder tissue from 15 patients...
March 10, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28290459/contemporary-update-on-neoadjuvant-therapy-for-bladder-cancer
#5
REVIEW
Daniel P Nguyen, George N Thalmann
Administration of neoadjuvant chemotherapy preceding radical cystectomy in patients with bladder cancer remains a matter of debate. Results of prospective, randomized studies have demonstrated an overall absolute survival benefit of 5% at 5 years, provided cisplatin-based combination regimens are used. Owing to the perception of a modest survival benefit, the medical community has been slow to adopt the use of neoadjuvant chemotherapy. Other reasons for the underuse of neoadjuvant chemotherapy range from patient ineligibility to fear of delaying potentially curative surgery in nonresponders...
March 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28286068/efficacy-of-bacillus-calmette-guerin-strains-for-the-treatment-of-non-muscle-invasive-bladder-cancer-a-systematic-review-and-network-meta-analysis
#6
REVIEW
Brock E Boehm, John E Cornell, Hanzhang Wang, Neelam Mukherjee, Jacob S Oppenheimer, Robert S Svatek
PURPOSE: To determine the efficacy of genetically distinct Bacillus Calmette-Guérin (BCG) strains in preventing disease recurrence for patients with non-muscle invasive bladder cancer (NMIBC). EXPERIMENTAL DESIGN: We conducted a systematic review and network meta-analysis of trials evaluating BCG strains against all possible comparators (different BCG strains, chemotherapy, and non-BCG biologic therapies) and intravesical chemotherapy as the common comparator. MEDLINE served as the primary data source, with search from inception to October 2016 for clinical trials involving patients with NMIBC receiving BCG...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28283914/transurethral-resection-of-bladder-tumors-improving-quality-through-new-techniques-and-technologies
#7
REVIEW
Daniel Zainfeld, Siamak Daneshmand
PURPOSE OF REVIEW: Cystoscopy with transurethral resection of bladder tumors (TURBT) is essential in the diagnosis of bladder cancer as well as the management of non-muscle-invasive disease yet remains a comparatively imprecise procedure secondary to variability among patients, tumors, and surgeons alike. We will review evolving technologies and techniques used to enhance safety and efficacy of TURBT performance and education in the management of bladder cancer. RECENT FINDINGS: Though a generally safe procedure, efficacy of TURBT in terms of complete tumor excision, appropriate pathologic diagnosis, and absence of complications can vary significantly with direct impact on patient outcomes...
May 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28281310/effectiveness-of-platinum-based-adjuvant-chemotherapy-for-muscle-invasive-bladder-cancer-a-weighted-propensity-score-analysis
#8
Fumitaka Shimizu, Satoru Muto, Masataka Taguri, Takeshi Ieda, Akira Tsujimura, Yoshiro Sakamoto, Kazuhiko Fujita, Takatsugu Okegawa, Raizo Yamaguchi, Shigeo Horie
OBJECTIVES: To evaluate the clinical benefit of adjuvant platinum-based chemotherapy after radical cystectomy for muscle-invasive bladder cancer in routine clinical practice. METHODS: The present observational study was carried out to compare the effectiveness of adjuvant chemotherapy versus observation post-radical cystectomy in patients with clinically muscle-invasive bladder cancer. Cancer-specific survival and overall survival between the adjuvant chemotherapy group and radical cystectomy alone group were compared using Kaplan-Meier method and log-rank test...
March 9, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28280928/urothelial-carcinoma-in-first-histological-diagnosis-of-patients-over-80%C3%A2-years-has-distinctive-histological-features-a-retrospective-single-institution-study-of-185-patients
#9
Adeline Furudoï, Justine Varinot, Véronique Phe, Morgan Roupret, Marc-Olivier Bitker, Eva Compérat
Few histological data are known about patients with a first diagnosis of bladder cancer (BC) at the age ≥80 years. We describe the largest series in this patient group and their distinctive histological features. This unicentric retrospective study included patients at the age ≥80 years with a first diagnosis of bladder cancer between 2005 and 2015. All diagnosis was made by one senior uropathologist according to the WHO 2016 classification, pTNM 7th edition 2009. We examined samples of 185 patients, sex ratio M:W = 2...
March 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28279796/tetrahydroporphyrin-tetratosylat-thpts-a-near-infrared-photosensitizer-for-targeted-and-efficient-photodynamic-therapy-pdt-of-human-bladder-carcinoma-an-in-vitro-study
#10
Mandy Berndt-Paetz, Annett Weimann, Nadine Sieger, Stanislaw Schastak, Yasser M Riyad, Jan Griebel, Vinodh K A Arthanareeswaran, Jens-Uwe Stolzenburg, Jochen Neuhaus
BACKGROUND: Efficacy of PDT in muscle-invasive bladder cancer is hampered by low tissue penetration of most photosensitizers by short excitation wavelength. THPTS is excitable at near-infrared (760nm) allowing tissue penetration up to 15mm. We examined the cellular effects of THPTS-PDT in human bladder cancer cells. MATERIAL AND METHODS: We used four human transitional carcinoma cell lines, epithelial bladder progenitors (HBLAK) and bladder smooth muscle cells (HBSMC)...
March 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28279061/development-and-validation-of-the-korean-version-of-the-european-organization-for-research-and-treatment-of-cancer-quality-of-life-questionnaire-for-patients-with-non-muscle-invasive-bladder-cancer-eortc-qlq-nmibc24
#11
Jinsung Park, Dong Wook Shin, Tae-Hwan Kim, Seung Il Jung, Jong Kil Nam, Seung Chol Park, Sungwoo Hong, Jae Hung Jung, Hong-Wook Kim, Won Tae Kim
Purpose: We aimed to evaluate psychometric properties of the Korean version of the EORTC QLQ-NMIBC24 when applied to Korean non-muscle invasive bladder cancer (NMIBC) patients. Materials and Methods: A total of 249 patients who underwent curative transurethral resection of bladder tumor (TURBT) for primary or recurrent NMIBC were asked to complete the Korean version of EORTC QLQ-C30 and NMIBC24 questionnaires three times (preoperative, post-TURBT 3 months and 6 months)...
March 10, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28275520/the-value-of-extended-good-quality-transurethral-resection-of-bladder-tumour-in-the-treatment-of-the-newly-diagnosed-bladder-cancer
#12
Mohamed Adel Atta, Ahmed Fouad Kotb, Mohamed Sharafeldeen, Ahmed Elabbady, Mohamed Mohie Hashad
OBJECTIVE: To report our experience for the initial management of patients with newly diagnosed bladder tumours using our team approach for each case and using an aggressive extended transurethral resection of bladder tumour (TURBT) in order to investigate the real need for a routine 'second-look' cystoscopy in the current era. PATIENTS AND METHODS: The study included 50 consecutive patients admitted to the urology department, of our tertiary care centre, for management of newly diagnosed bladder cancer...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28274590/role-of-inflammation-in-the-perioperative-management-of-urothelial-bladder-cancer-with-squamous-cell-features-impact-of-neutrophil-to-lymphocyte-ratio-on-outcomes-and-response-to-neoadjuvant-chemotherapy
#13
Oscar Buisan, Anna Orsola, Mario Oliveira, Roberto Martinez, Olatz Etxaniz, Joan Areal, Luis Ibarz
BACKGROUND: Neutrophil-to-lymphocyte ratio (NLR) might reflect an increased neutrophilic inflammatory response, and urothelial tumors with squamous-cell features (SqD) have been linked to inflammation. We hypothesized that NLR could be prognostic in these patients. PATIENTS AND METHODS: In patients with SqD muscle-invasive bladder cancer treated with curative intent, NLR and relationships with outcomes were analyzed by Cox regression, log-rank, and Kaplan-Meier analysis...
February 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28272009/neoadjuvant-chemotherapy-a-new-standard-for-muscle-invasive-bladder-cancer
#14
Nabil Ismaili
Bladder cancer is the seventh most common cancer and the ninth most common cause of cancer deaths for men worldwide. Cystectomy with pelvic lymph nodes dissection is the standard local treatment of muscle invasive bladder cancer (MIBC) (T2-T4). In the last decade, the management of MIBC had become multidisciplinary involving peri-operative chemotherapy (neo- or adjuvant chemotherapy). Randomized trials and meta-analyses confirmed the survival benefit of neoadjuvant chemotherapy before local treatment (surgery and/or radiotherapy)...
January 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28270951/applicability-of-the-eortc-risk-tables-to-predict-outcomes-in-non-muscle-invasive-bladder-cancer-in-turkish-patients
#15
Muhammet Fatih Kılınç, Göksel Bayar, Ayhan Dalkılıç, Nurettin Cem Sönmez, Serdar Arısan, Soner Güney
OBJECTIVE: To evaluate the consistency of the results of patients who were treated for non-muscle-invasive bladder cancer (NMIBC) in our clinic with the European Organization for Research and Treatment of Cancer (EORTC) risk table. MATERIAL AND METHODS: Data were retrospectively analyzed from 452 patients who had undergone transurethral resection of bladder tumor (TUR-BT) between the years 2002, and 2010 for primary or recurrent NMIBC. Our study had a retrospective design but based on prospective cohort study...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28270945/what-is-new-in-non-muscle-invasive-bladder-cancer-in-2016
#16
REVIEW
Ashish M Kamat, Murat Bağcıoğlu, Emre Huri
Approximately 75% of bladder cancers are non-muscle-invasive bladder cancer (NMIBC), and 50% of NMIBC patients who are treated with transurethral resection (TUR) have a recurrence of the disease and 5-25% of these patients progressed to muscle-invasive disease after repeated recurrences. NMIBC patients receive various treatments aimed at reducing disease recurrence and progression. Although the recurrence rate of disease remains above target, thus increasing treatment cost, the true rate of recurrence after the primary surgery is controversial...
March 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28268259/intravesical-bacillus-calmette-gu%C3%A3-rin-with-interferon-alpha-versus-intravesical-bacillus-calmette-gu%C3%A3-rin-for-treating-non-muscle-invasive-bladder-cancer
#17
REVIEW
Andrew Rh Shepherd, Emily Shepherd, Nicholas R Brook
BACKGROUND: Despite local therapies, commonly transurethral resection (TUR) followed by adjuvant treatments, non-muscle-invasive bladder cancer (NMIBC) has a high rate of recurrence and progression. Intravesical Bacillus Calmette-Guérin (BCG) has been shown to reduce recurrence and progression in people with NMIBC following TUR, however many people do not respond to treatment, have recurrence shortly after, or cannot tolerate standard-dose therapy. The potential for synergistic antitumour activity of interferon (IFN)-alpha (α) and BCG provides some rationale for combination therapy for people who do not tolerate or respond to standard-dose BCG therapy...
March 8, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28266904/clinical-relevance-of-narrow-band-imaging-in-flexible-cystoscopy-the-dablaca-7-study
#18
Ditte Drejer, Sami Béji, Anna Munk Nielsen, Søren Høyer, Gitte Wrist Lam, Jørgen B Jensen
OBJECTIVE: This multicenter study investigated whether the use of narrow-band imaging (NBI) in flexible cystoscopy could improve diagnostics to a degree where clinical management was relevantly changed. MATERIALS AND METHODS: From May 2014 to June 2015, 955 patients were enrolled at three Danish urological departments. Patients had either hematuria (n = 483) or known recurrent non-muscle-invasive bladder cancer (NMIBC) (n = 472). High-definition (HD) cystoscopy was performed in white light (WL) and a preliminary clinical decision was made...
March 7, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28266813/generation-of-potent-cytotoxic-t-lymphocytes-against-in-male-patients-with-non-muscle-invasive-bladder-cancer-by-dendritic-cells-loaded-with-dying-t24-bladder-cancer-cells
#19
Eu Chang Hwang, Seung Il Jung, Hyun-Ju Lee, Je-Jung Lee, Dong Deuk Kwon
BACKGROUND: In order to induce a potent cytotoxic T lymphocyte (CTL) response in dendritic cell (DC)-based immunotherapy for bladder cancer, various tumor antigens can be loaded onto DCs. OBJECTIVE: The aim of this study was to establish a method of immunotherapy for male patients with non-muscle invasive bladder cancer (NMIBC), using bladder cancer-specific CTLs generated in vitro by DCs. MATERIALS AND METHODS: Monocyte-derived DCs from bladder cancer patients were induced to mature in a standard cytokine cocktail (IL-1β, TNF-α, IL-6, and PGE2: standard DCs, sDCs) or anα-type 1-polarized DC (αDC1) cocktail (IL-1β, TNF-α, IFN-α, IFN-γ, and polyinosinic:polycytidylic acid) and loaded with the UVB-irradiated bladder cancer cell line, T24...
March 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28261684/evaluation-of-zinc-finger-e-box-binding-homeobox-1-and-transforming-growth-factor-beta2-expression-in-bladder-cancer-tissue-in-comparison-with-healthy-adjacent-tissue
#20
Ali Mahdavinezhad, Reza Yadegarazari, Seyed Habibollah Mousavi-Bahar, Jalal Poorolajal, Mohammad Jafari, Mohammad Ali Amirzargar, Hosein Effatpanah, Massoud Saidijam
PURPOSE: The fifth most common cancer is allocated to bladder cancer (BC) worldwide. Understanding the molecular mechanisms of BC invasion and metastasis to identify target therapeutic strategies will improve disease survival. So the aim of this study was to measure expression rate of zinc finger E-box binding homeobox 1 (ZEB1) and transforming growth factor-beta2 (TGF-β2) mRNA in tissue samples of patients with BC and its healthy adjacent tissue samples and their association with muscle invasion, size and grade of the tumor...
March 2017: Investigative and Clinical Urology
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