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Muscle invasive bladder cancer

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https://www.readbyqxmd.com/read/28938555/exosomes-of-invasive-urothelial-carcinoma-cells-are-characterized-by-a-specific-mirna-expression-signature
#1
Sophie Baumgart, Sebastian Hölters, Carsten-Henning Ohlmann, Rainer Bohle, Michael Stöckle, Marie Stampe Ostenfeld, Lars Dyrskjøt, Kerstin Junker, Joana Heinzelmann
Muscle-invasive bladder cancer (MIBC) represents a highly aggressive tumor type compared to non-muscle-invasive tumors. MIBC is characterized by specific molecular alterations, which may also modulate extracellular tumorigenic effects. Tumor-associated exosomes, especially exosomal miRNAs, are important regulators in the interaction between tumor cells and tumor microenvironment by affecting tumor-promoting processes in target cells. It is important to analyze whether their exosomal patterns also reflect the specific molecular characteristics of MIBC...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936147/lymph-node-density-in-muscle-invasive-transitional-cell-carcinoma-of-the-urinary-bladder-de-novo-versus-progressive-disease
#2
Ahmed Elabbady, Mohamed Mohieeldin Hashad, Ahmed Fouad Kotb, Dina Mohamed Abdullah, Ahmad Beltagy
OBJECTIVE: The prognosis of bladder cancer patients with positive lymph node (LN) disease is affected by both the extent of lymphadenectomy and LN density retrieved during radical cystectomy. This study aimed at assessing the differences in LN metastasis between patients who presented primarily with muscle-invasive transitional cell carcinoma of the bladder "de novo disease" versus "progressive disease." The latter is defined as patients who progressed to muscle-invasive bladder cancer (MIBC) following prior conservative management of a non-muscle-invasive disease...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28928159/bmp4-induces-m2-macrophage-polarization-and-favors-tumor-progression-in-bladder-cancer
#3
Víctor G Martínez, Carolina Rubio, Mónica Martínez-Fernández, Cristina Segovia, Fernando López-Calderón, Marina Garín, Alicia Teijeira, Ester Munera-Maravilla, Alberto Varas, Rosa Sacedón, Felix Guerrero-Ramos, Felipe Villacampa, Federico de la Rosa, Daniel Castellano, Eduardo López-Collazo, Jesus M Paramio, Ángeles Vicente, Marta Dueñas
PURPOSE: Bladder cancer (BC) is a current clinical and social problem. At diagnosis, most patients present non-muscle invasive tumors, characterized by a high recurrence rate, which could progress to muscle invasive disease and metastasis. Bone morphogenetic protein (BMP)-dependent signaling arising from stromal bladder tissue mediates urothelial homeostasis by promoting urothelial cell differentiation. However, the possible role of BMP ligands in BC is still unclear. EXPERIMENTAL DESIGN: Tumor and normal tissue from 68 patients with urothelial cancer were prospectively collected and analyzed for expression of BMP and macrophage markers...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28923700/venous-thromboembolism-risk-in-patients-with-locoregional-urothelial-tract-tumors
#4
Jorge D Ramos, Jonathan T Wingate, Roman Gulati, Elizabeth R Plimack, Lauren C Harshman, Thomas Powles, Simon J Crabb, Guenter Niegisch, Joaquim Bellmunt, Sylvain Ladoire, Ugo De Giorgi, Syed Hussain, Ajjai S Alva, Jack Baniel, Neeraj Agarwal, Jonathan E Rosenberg, Ulka N Vaishampayan, Matthew D Galsky, Evan Y Yu
BACKGROUND: Venous thromboembolism (VTE) is common in cancer patients, but there is limited data on patients with urothelial tract tumors (UTT). We previously identified several associative factors for increased VTE rates in patients with metastatic UTT. In this study, we assessed the frequency, associative factors, and impact on survival of VTE in patients with locoregional UTT. METHODS: Patients with locoregional bladder, upper urinary tract, or urethral cancer were included in this multi-center study from 29 academic institutions...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28920525/can-urologists-accurately-stage-and-grade-urothelial-bladder-cancer-by-assessing-endoscopic-photographs
#5
Snir Dekalo, Haim Matzkin, Nicola J Mabjeesh
Introduction Assessment of urothelial bladder cancer during cystoscopy or transurethral resection of bladder tumour has a significant impact on the urologist's decision-making: treatment with simple outpatient fulguration, required depth of resection, and need of immediate post-surgical intravesical therapy. These choices depend heavily on the urologist's ability to accurately assess pre-biopsy tumour stage and grade. The aim of the study was to determine whether evaluation of photographs taken during transurethral resection of bladder tumour can reliably characterize a tumour's stage and grade...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28916862/monitoring-the-response-of-urothelial-precancerous-lesions-to-bacillus-calmette-guerin-at-the-proteome-level-in-an-in-vivo-rat-model
#6
Kerem Teke, Nil Guzel, Ali Kemal Uslubas, Murat Kasap, Hasan Yilmaz, Gurler Akpinar, Demir Kursat Yildiz, Ozdal Dillioglugil
Intravesical Bacillus Calmette-Guerin (BCG) is the best treatment modality for progression of non-muscle invasive bladder cancer. We aimed to monitor changes at the proteome level to identify putative protein biomarkers associated with the response of urothelial precancerous lesions to intravesical BCG treatment. The rats were divided into three groups (n = 10/group): control, non-treated, and BCG-treated groups. The non-treated and BCG-treated groups received N-methyl-N-nitrosourea intravesically. BCG Tice-strain was instilled into bladder in BCG-treated group...
September 15, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28916253/the-place-of-transanal-endoscopic-surgery-in-the-treatment-of-recto-urethral-fistula
#7
X Serra-Aracil, M Labro-Ciurans, L Mora-Lopez, J Muñoz-Rodriguez, R Martos-Calvo, J Prats-López, S Navarro-Soto
OBJECTIVES: To assess the role of TEO/TEM in recto-urethral fistulas (RUF). RUF may appear after radical prostatectomy. Their treatment represents a challenge; many therapies have been proposed, from conservative to aggressive surgical approaches. Transanal endoscopic surgery (TEO/TEM) is a minimally invasive technique to access the site of the RUF to perform repair. METHODS: Observational study with prospective data collection, conducted between September 2006 and December 2015...
September 12, 2017: Urology
https://www.readbyqxmd.com/read/28913158/dosimetry-and-first-human-experience-with-89-zr-panitumumab
#8
Liza Lindenberg, Stephen Adler, Ismail B Turkbey, Francesca Mertan, Anita Ton, Khanh Do, Shivaani Kummar, Esther Mena Gonzalez, Sibaprasad Bhattacharyya, Paula M Jacobs, Peter Choyke
(89)Zr-panitumumab is a novel immuno-PET radiotracer. A fully humanized IgG2 antibody, panitumumab binds with high affinity to the extracellular ligand binding domain of EGFR. Immuno-PET with radiolabeled panitumumab is a non-invasive method that could characterize EGFR expression in tumors and metastatic lesions. It might also assist in selecting patients likely to benefit from targeted therapy as well as monitor response and drug biodistribution for dosing guidance. Our objective was to calculate the maximum dosing for effective imaging with minimal radiation exposure in a small subset...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28911924/sialyl-tn-identifies-muscle-invasive-bladder-cancer-basal-and-luminal-subtypes-facing-decreased-survival-being-expressed-by-circulating-tumor-cells-and-metastases
#9
Luís Lima, Manuel Neves, Marta I Oliveira, Lorena Dieguez, Rui Freitas, Rita Azevedo, Cristiana Gaiteiro, Janine Soares, Dylan Ferreira, Andreia Peixoto, Elisabete Fernandes, Diana Montezuma, Ana Tavares, Ricardo Ribeiro, Ana Castro, Manuel Oliveira, Avelino Fraga, Celso A Reis, Lúcio Lara Santos, José Alexandre Ferreira
OBJECTIVES: To evaluate the potential of sialyl-Tn (STn), a cancer-associated glycan antigen present in membrane glycoproteins, to improve a recent molecular model for stratification and prognostication of advanced stage bladder tumors based on keratins (KRT14, 5, and 20) expression. In addition, determine the association between STn and disease dissemination based on the evaluation of circulating tumor cells (CTCs) and the metastasis, which is a critical matter to improve patient management...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28902383/-bcgitis-with-involvement-of-lung-liver-and-bone-marrow%C3%A2-after-immunotherapy-of-urothelial-cancer
#10
Hilte Friederike Geerdes-Fenge, Franziska Stubbe, Micha Löbermann, Philipp Warnke, Andreas Erbersdobler, Emil Christian Reisinger
Medical history A 77-year-old patient with transurethral resection of a bladder tumor was transferred due to persistent fever and progressive dyspnea despite antibiotic therapy for suspected urinary tract infection. Repeating the medical history revealed that a BCG immunotherapy of his non-muscle-invasive bladder carcinoma was performed the day before fever developed. Therefore, BCGitis was suspected. Examinations Laboratory parameters showed pancytopenia, elevated liver enzymes, eleveated C-reactive protein and hypoxemia...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28899722/effect-of-nonurothelial-histologic-variants-on-the-outcomes-of-radical-cystectomy-for-nonmetastatic-muscle-invasive-urinary-bladder-cancer
#11
Malte W Vetterlein, Thomas Seisen, Jeffrey J Leow, Mark A Preston, Maxine Sun, David F Friedlander, Christian P Meyer, Felix K-H Chun, Stuart R Lipsitz, Mani Menon, Adam S Kibel, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
INTRODUCTION: Knowledge of the comparative oncologic outcomes of histologic variants after radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) relies on small case series. We compared the effect of pure squamous cell carcinoma, adenocarcinoma, and neuroendocrine carcinoma compared with pure urothelial carcinoma (PUC) on overall survival (OS) and pathologic tumor, lymph node, and surgical margin status after RC. PATIENTS AND METHODS: Using the National Cancer Database, we retrospectively examined patients undergoing RC for MIBC from 2003 to 2011...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28898400/intravesical-electromotive-drug-administration-for-non-muscle-invasive-bladder-cancer
#12
REVIEW
Jae Hung Jung, Ahmet Gudeloglu, Halil Kiziloz, Gretchen M Kuntz, Alea Miller, Badrinath R Konety, Philipp Dahm
BACKGROUND: Electromotive drug administration (EMDA) is the use of electrical current to improve the delivery of intravesical agents to reduce the risk of recurrence in people with non-muscle invasive bladder cancer (NMIBC). It is unclear how effective this is in comparison to other forms of intravesical therapy. OBJECTIVES: To assess the effects of intravesical EMDA for the treatment of NMIBC. SEARCH METHODS: We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EMBASE), two clinical trial registries and a grey literature repository...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28890885/evaluation-of-microrna-99a-and-microrna-205-expression-levels-in-bladder-cancer
#13
Sajjad Mohammad Ganji, Massoud Saidijam, Razieh Amini, Seyed Habibollah Mousavi-Bahar, Nooshin Shabab, Saman Seyedabadi, Ali Mahdavinezhad
Bladder cancer is the second most common cancer in the genitourinary tract, showing often recurrence and progress into invasive states. Epigenetic changes, such as microRNA alteration are involved in bladder cancer tumorigenesis through a variety of signaling pathways. The epigenetic state depends on geographic and lifestyle conditions. The aim of this study was to investigate the expression level of microRNA-99a and microRNA-205 in bladder cancer in Iranian populations and to determine the relationship between their expressions with clinicophatological features...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28889382/urothelial-carcinoma-stem-cells-current-concepts-controversies-and-methods
#14
Jiri Hatina, Hamendra Singh Parmar, Michaela Kripnerova, Anastasia Hepburn, Rakesh Heer
Cancer stem cells are defined as a self-renewing and self-protecting subpopulation of cancer cells able to differentiate into morphologically and functionally diverse cancer cells with a limited lifespan. To purify cancer stem cells, two basic approaches can be applied, the marker-based approach employing various more of less-specific cell surface marker molecules and a marker-free approach largely based on various self-protection mechanisms. Within the context of urothelial carcinoma, both methods could find use...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28889377/molecular-subtype-profiling-of-urothelial-carcinoma-using-a-subtype-specific-immunohistochemistry-panel
#15
Gottfrid Sjödahl
Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. For analysis of MI tumors, 13 markers are needed...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28888813/gender-specific-differences-in-recurrence-of-non-muscle-invasive-bladder-cancer-a-systematic-review-and-meta-analysis
#16
REVIEW
Annemarie Uhlig, Arne Strauss, Ali Seif Amir Hosseini, Joachim Lotz, Lutz Trojan, Marianne Schmid, Johannes Uhlig
CONTEXT: The incidence of urothelial carcinoma of the bladder (UCB) is lower in women; however, women tend to present with more advanced disease. To date, there is no quantitative synthesis of studies reporting gender-specific outcomes in non-muscle-invasive UCB. OBJECTIVE: To conduct a meta-analysis evaluating gender-specific differences in recurrence of non-muscle-invasive urinary bladder cancer (NMIBC). EVIDENCE ACQUISITION: An unrestricted systematic literature search of the MEDLINE, EMBASE, and Cochrane libraries was conducted...
September 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28888228/transperineal-cryotherapy-for-unresectable-muscle-invasive-bladder-cancer-preliminary-experience-with-7-male-patients
#17
Qing Zhang, Shiwei Zhang, Shun Zhang, Wei Wang, Xiaozhi Zhao, Yongming Deng, Huibo Lian, Hongqian Guo
BACKGROUND: Radical cystectomy (RC) with pelvic lymph node dissection (PLND) and urinary diversion (UD) is considered the standard treatment for muscle invasive bladder cancer (MIBC). In a part of patients, RC procedure is aborted due to unresectable disease, other followed treatment like systemic chemotherapy, radiotherapy or cryotherapy may be a better option. The aim of present study was to report the preliminary results of transperineal cryotherapy for unresectable muscle invasive bladder cancer...
September 9, 2017: BMC Urology
https://www.readbyqxmd.com/read/28882129/igf1r-activation-and-the-in-vitro-antiproliferative-efficacy-of-igf1r-inhibitor-are-inversely-correlated-with-igfbp5-expression-in-bladder-cancer
#18
Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi, Isabelle Bernard-Pierrot
BACKGROUND: The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway - insulin growth factor receptors (INSR, IGF1R, IGF2R), ligands (INS, IGF1, IGF2), and binding proteins (IGFBP1-7, IGF2BP1-3) - in bladder cancer and its correlation with IGF1R activation, and the anti-proliferative efficacy of an IGF1R kinase inhibitor in this setting. METHODS: We analyzed transcriptomic data from two independent bladder cancer datasets, corresponding to 200 tumoral and five normal urothelium samples...
September 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28881802/mek-inhibition-enhances-efficacy-of-bacillus-calmette-gu%C3%A3-rin-on-bladder-cancer-cells-by-reducing-release-of-toll-like-receptor-2-activated-antimicrobial-peptides
#19
Young Mi Whang, Su Bin Jin, Serk In Park, In Ho Chang
Bacillus Calmette-Guérin (BCG) is one of the standard treatment options for non-muscle-invasive bladder cancer. The details of the biological defense mechanisms against BCG remain unclear. Here, we investigated whether BCG-induced release of antimicrobial peptides (AMPs; e.g., human β-defensin-2, -3, and cathelicidin) is involved with mitogen-activated protein kinase (MAPK) pathways, and investigated the enhanced anticancer effect of BCG through the down-regulation of Toll-like receptors (TLRs) and MAPK pathways in bladder cancer cells...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881595/effects-of-increased-kindlin-2-expression-in-bladder-cancer-stromal-fibroblasts
#20
Jitao Wu, Cuicui Yu, Li Cai, Youyi Lu, Lei Jiang, Chu Liu, Yongwei Li, Fan Feng, Zhenli Gao, Zhe Zhu, Shengqiang Yu, Hejia Yuan, Yuanshan Cui
Kindlin-2 is a focal adhesion protein highly expressed in bladder cancer stromal fibroblasts. We investigated the prognostic significance of Kindlin-2 in bladder cancer stromal fibroblasts and evaluated the effects of Kindlin-2 on the malignant behaviors of tumor cells. Immunohistochemical staining of 203 paraffin-embedded bladder cancer tissues showed that Kindlin-2 expression correlated with advanced stage, high grade, and relapse of bladder cancer. Kaplan-Meier survival analysis demonstrated that patients exhibiting high Kindlin-2 expression had shorter survival times than those with low Kindlin-2 expression (p < 0...
August 1, 2017: Oncotarget
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