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Cerebral vascular endothelial injury

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https://www.readbyqxmd.com/read/29299743/basic-fibroblast-growth-factor-protects-astrocytes-against-ischemia-reperfusion-injury-by-upregulating-the-caveolin-1-vegf-signaling-pathway
#1
Meixia Liu, Yudan Wu, Yidian Liu, Zhenzhen Chen, Shujuan He, Huimei Zhang, Liang Wu, Fengxia Tu, Yun Zhao, Chan Liu, Xiang Chen
A previous in vivo study demonstrated that intracerebroventricular injection of basic fibroblast growth factor (bFGF) in middle cerebral artery occlusion rats increased the expression of caveolin-1 (cav-1) and vascular endothelial growth factor (VEGF) in cerebral ischemia penumbra. Because astrocytes are the largest population in the brain, the aim of this in vitro study was to investigate the influence of bFGF on cav-1 and VEGF expression in rat astrocytes following oxygen glucose deprivation/reoxygenation (OGD/R)...
January 3, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29248560/vegf-attenuates-2-vo-induced-cognitive-impairment-and-neuronal-injury-associated-with-the-activation-of-pi3k-akt-and-notch1-pathway
#2
Ling Wang, Faqi Wang, Shuang Liu, Xuening Yang, Jiajia Yang, Dong Ming
Vascular endothelial growth factor (VEGF) has been identified as a potential treatment for effectively improving cognitive function in several neuropathological conditions. However, the underlying mechanism and the relevant downstream protective pathways that are activated in neurons by VEGF remain elusive, especially in chronic global cerebral ischemia. In this study, we intended to investigate the signaling mechanisms of VEGF in cognitive protection and anti-apoptosis in a rat model of chronic global cerebral ischemia induced by permanent bilateral common carotid artery occlusion (2-VO)...
December 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29247478/chinese-medicine-tongxinluo-capsule-alleviates-cerebral-microcirculatory-disturbances-in-ischemic-stroke-by-modulating-vascular-endothelial-function-and-inhibiting-leukocyte-endothelial-cell-interactions-in-mice-a-two-photon-laser-scanning-microscopy-study
#3
Shen Liu, Cong Wei, Ning Kang, Qilong He, Junqing Liang, Hongtao Wang, Liping Chang, Daohong Chen, Qiuyan Zhang, Chengcheng Chang, Junfang Zhang, Hong Ren, Yiling Wu
OBJECTIVE: The aim of this study was to examine the effect of Tongxinluo capsule (TXL), a Chinese medicine prescription, on cerebral microcirculatory disturbances after permanent middle cerebral artery occlusion (pMCAO) in mice using two-photon laser scanning microscopy (TPLSM) and further explore the underlying mechanisms. METHODS: C57BL/6J mice were subjected to pMCAO and orally administered with TXL (3.0, 1.5 and 0.75 g/kg/day) at 1h, 3h and 21h after pMCAO. The following parameters were examined at 6h and 24h after pMCAO: neurological deficit, infarct volume, blood-brain barrier (BBB) permeability, cerebral microvessel structure, brain microcirculation (TPLSM imaging), vasoactive factors and adhesion molecules...
December 15, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29209923/plasma-microparticles-in-alzheimer-s-disease-the-role-of-vascular-dysfunction
#4
Soheila Hosseinzadeh, Maryam Noroozian, Esmaeil Mortaz, Kazem Mousavizadeh
Cerebrovascular lesions, a potent stimulus for endothelial cell activation, trigger cognitive and degenerative changes and contribute to pathology of Alzheimer's disease (AD). Circulating microparticles (MPs) are actively involved in the pathogenesis of AD and cerebrovascular diseases, which share common vascular risk factors. We examined the plasma changes of endothelial MPs (EMPs) and platelet MPs (PMPs) in AD patients with vascular risk factors. The plasma Annexin V+ CD 41a- CD144+ EMPs and Annexin V+ CD41a+ CD144- PMPs of 37 patients with AD, with or without vascular risk factors (hypertension, diabetes, dyslipidemia, stroke, coronary artery disease, and smoking), and 10 age-matched controls were quantified by flow cytometry...
December 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29201838/ganoderma-lucidum-protects-rat-brain-tissue-against-trauma-induced-oxidative-stress
#5
Özevren Hüseyin, İrtegün Sevgi, Deveci Engin, Aşır Fırat, Pektanç Gülsüm, Deveci Şenay
Objective: Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. This study aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs) on brain injury in brain-traumatized rats. Methods: Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height. Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum (20 mL/kg per day via gastric gavage)...
October 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/29180303/effects-of-erythropoietin-on-astrocytes-and-brain-endothelial-cells-in-primary-culture-during-anoxia-depend-on-simultaneous-signaling-by-other-cytokines-and-on-duration-of-anoxia
#6
Hameed Al-Sarraf, Slava Malatiali, Mariam Al-Awadi, Zoran Redzic
Studies on animals revealed neuroprotective effects of exogenously applied erythropoietin (EPO) during cerebral ischemia/hypoxia. Yet, application of exogenous EPO in stroke patients often lead to haemorrhagic transformation. To clarify potential mechanism of this adverse effect we explored effects of EPO on viabilities of astrocytes and brain endothelial cells (BECs) in primary culture during anoxia of various durations, in the presence or absence of vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1), which are cytokines that are also released from the neurovascular unit during hypoxia...
November 24, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29176141/safflower-extract-and-aceglutamide-injection-promoting-recovery-of-peripheral-innervations-via-vascular-endothelial-growth-factor-b-signaling-in-diabetic-mice
#7
Dan Li, You-Gang Chen, Cui-Juan Zhang, Jing Tian, Xia Li
BACKGROUND: Safflower extract and aceglutamide (SA) has been used clinically for the treatment of cerebrovascular diseases such as cerebral embolism, hemorrhage, and mental deterioration. This study aimed to investigate the effect and mechanism of SA injection in the recovery of peripheral innervations of diabetic mice. METHODS: The C57BL/6 male mice were divided into four groups: normal control group (n = 44), diabetic group (n = 44), diabetic + SA group (diabetic mice treated with SA injection, n = 44), and diabetic + SA + vascular endothelial growth factor receptor (VEGFR)1-BL group (diabetic mice treated with SA injection and VEGFR 1 blocking antibody n = 24)...
December 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29175152/transplantation-of-human-umbilical-cord-blood-mononuclear-cells-attenuated-ischemic-injury-in-mcao-rats-via-inhibition-of-nf-%C3%AE%C2%BAb-andnlrp3inflammasome
#8
Lu Liu, Juan Cen, Yong Man, Jianbin Li, Dahuan Zhang, Fei Wang, Jinhua Li, Ji Ma, Xiaoming Wang, Biansheng Ji
Accumulated evidences displayed that transplantation of stem cells may be a promising approach for the treatment of neurological disorders. However, the underlying mechanisms remain to be well elucidated. Moreover, some investigators can not reproduce similar results as the previous. The present results showed that transplantation of fresh human umbilical cord blood mononuclear cells (cbMNCs) attenuated ischemic damage in middle cerebral artery occlusion (MCAO) rats, accompanied with improvement of neurologic deficits, learning and memory function...
November 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/29175057/simvastatin-blocks-soluble-ssao-vap-1-release-in-experimental-models-of-cerebral-ischemia-possible-benefits-for-stroke-induced-inflammation-control
#9
Ping Sun, Mar Hernandez-Guillamón, Mireia Campos-Martorell, Alba Simats, Joan Montaner, Mercedes Unzeta, Montse Solé
Beyond cholesterol reduction, statins mediate their beneficial effects on stroke patients through pleiotropic actions. They have shown anti-inflammatory properties by a number of different mechanisms, including the inhibition of NF-κB transcriptional activity and the consequent increase and release of adhesion molecules. We have studied simvastatin's effects on the vascular enzyme semicarbazide-sensitive amine oxidase/vascular adhesion protein 1 (SSAO/VAP-1), which is involved in stroke-mediated brain injury...
November 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29121798/angelica-sinensis-exerts-angiogenic-and-anti-apoptotic-effects-against-cerebral-ischemia-reperfusion-injury-by-activating-p38mapk-hif-1-formula-see-text-vegf-a-signaling-in-rats
#10
Chin-Yi Cheng, Tin-Yun Ho, Chien-Yun Hsiang, Nou-Ying Tang, Ching-Liang Hsieh, Shung-Te Kao, Yu-Chen Lee
This study evaluated the effects of Angelica sinensis extract [Dang Gui (DG)] administered before 60[Formula: see text]min of middle cerebral artery occlusion followed by 3[Formula: see text]d of reperfusion and investigated the involvement of mitogen-activated protein kinase (MAPK)/hypoxia-inducible factor (HIF)-1[Formula: see text] signaling in the cortical ischemic penumbra. DG was intraperitoneally administered at a dose of 0.25[Formula: see text]g/kg (DG-0.25g), 0.5[Formula: see text]g/kg (DG-0.5g), or 1[Formula: see text]g/kg (DG-1g) 30[Formula: see text]min before the onset of cerebral ischemia...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29098173/the-roles-of-endoglin-gene-in-cerebrovascular-diseases
#11
Wan Zhu, Li Ma, Rui Zhang, Hua Su
Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis. Angiogenesis is important in the development of cerebral vasculature and in the pathogenesis of cerebral vascular diseases. ENG is an essential component of the endothelial nitric oxide synthase activation complex. Animal studies showed that ENG deficiency impairs stroke recovery. ENG deficiency also impairs the regulation of vascular tone, which contributes to the pathogenesis of brain arteriovenous malformation (bAVM) and vasospasm...
2017: Neuroimmunology and Neuroinflammation
https://www.readbyqxmd.com/read/29061393/repulsive-guidance-molecule-a-suppresses-angiogenesis-after-ischemia-reperfusion-injury-of-middle-cerebral-artery-occlusion-in-rats
#12
Yu Wang, Rongrong Zhang, Xiangfeng Xing, Jia Guo, Fei Xie, Gang Zhang, Xinyue Qin
Repulsive guidance molecule a (RGMa) has now emerged as a molecule with pleiotropic roles, including repulsion, adhesion, migration and differentiation in the nervous system. In this study, adult male Sprague-Dawley (SD) rats received 90-min middle cerebral artery occlusion (MCAO) to observe RGMa/neogenin expression sites after ischemia/reperfusion injury and changes in angiogenesis after treatment with RNA interference using RGMa-specific recombinant adenovirus rAd5-shRNA-RGMa (rAd-shRGMa). To clarify how RGMa mediates angiogenesis, the RGMa function-blocking peptide six fibronectin type III (6FNIII) was also administered, and corresponding changes in vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang2), angiopoietin-1 (Ang1), and brain derived neurotrophic factor (BDNF) were determined by western blotting...
October 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29042193/microrna-126-3p-attenuates-blood-brain-barrier-disruption-cerebral-edema-and-neuronal-injury-following-intracerebral-hemorrhage-by-regulating-pik3r2-and-akt
#13
Tianyang Xi, Feng Jin, Ying Zhu, Jialu Wang, Ling Tang, Yanzhe Wang, David S Liebeskind, Zhiyi He
MiR-126, a microRNA implicated in blood vessel integrity, angiogenesis and vascular inflammation, is markedly decreased in the sera of patients with intracerebral hemorrhage (ICH). The current study aims to evaluate the potential therapeutic effect of miR-126-3p on brain injuries in a rat model of collagenase-induced ICH. Intracerebroventricular administration of a miR-126-3p mimic significantly alleviated behavioral defects 24 h after ICH, as examined by paw placement and corner tests. ICH led to increased blood-brain barrier (BBB) permeability and cerebral edema, both of which were attenuated by miR-126-3p mimic...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29039513/birc5-is-a-novel-target-of-peroxisome-proliferator%C3%A2-activated-receptor-%C3%AE-in-brain-microvascular-endothelium-cells-during-cerebral-ischemia
#14
Mingjing Xu, Xianli Yang, Qing Zeng, He He, Pengcheng Lu, Guozhi Huang
Cerebral ischemia is a leading cause of ischemic stroke, which may lead to severe disability and mortality worldwide. There are some key factors concerned in cardioprotection, such as peroxisome proliferator‑activated receptor γ (PPARγ), a ligand binding transcription factor involved in various biological functions including atherosclerosis, vascular dysfunction and hypertension, and baculoviral IAP repeat‑containing 5 (BIRC5), which may protect human brain endothelial cells from ischemia‑induced apoptosis...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038540/regulation-of-endothelial-intracellular-adenosine-via-adenosine-kinase-epigenetically-modulates-vascular-inflammation
#15
Yiming Xu, Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou, Xianqiu Zeng, Zhiping Liu, Xiaofei An, Haroldo A Toque, Zheng Dong, Xuejun Jiang, David J Fulton, Neal L Weintraub, Qinkai Li, Zsolt Bagi, Mei Hong, Detlev Boison, Chaodong Wu, Yuqing Huo
The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial inflammation by increasing endothelial ADK expression, reducing the level of intracellular adenosine in endothelial cells, and activating the transmethylation pathway through increasing the association of ADK with S-adenosylhomocysteine (SAH) hydrolase (SAHH)...
October 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/29023577/sevoflurane-protects-rat-brain-endothelial-barrier-structure-and-function-after-hypoxia-reoxygenation-injury
#16
Tanja Restin, Marie-Elisabeth Kajdi, Martin Schläpfer, Birgit Roth Z'graggen, Christa Booy, Claudia Dumrese, Beatrice Beck-Schimmer
BACKGROUND: After cerebral injury blood-brain barrier disruption significantly impairs brain homeostasis. Volatile anesthetics have been shown to be protective in ischemia-reperfusion injury scenarios. Their impact on brain endothelial cells after hypoxia-reoxygenation (H/R) has not yet been studied in detail. METHODS: Rat brain endothelial cells (RBE4) were exposed to severe hypoxia and reoxygenated in air in the presence or absence of sevoflurane. Changes in dextran permeability and architecture of the cellular junctional proteins ZO-1 and β-catenin were measured...
2017: PloS One
https://www.readbyqxmd.com/read/28986333/protective-effect-of-danhong-injection-combined-with-naoxintong-capsule-on-cerebral-ischemia-reperfusion-injury-in-rats
#17
Jiayang Wan, Haofang Wan, Rongbin Yang, Haitong Wan, Jiehong Yang, Yu He, Huifen Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Danhong Injection (DHI) and Naoxintong Capsule (NXT) are renowned traditional Chinese medicine in China. The drug combination of DHI and NXT is frequently applied for the treatment of cardiovascular and cerebrovascular diseases in clinic. However, there had been no pharmacological experiment studies of interaction between DHI and NXT. Due to the drug interactions, exploring their interaction profile is of great importance. MATERIAL AND METHODS: In this study, focal cerebral I/R injury in adult male Sprague-Dawley rats were induced by transient middle cerebral artery occlusion (tMCAO) for 1h followed by reperfusion...
October 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28983620/implantation-of-bone-mesenchymal-stem-cells-overexpressing-mirna%C3%A2-705-mitigated-ischemic-brain-injury
#18
Meng Ji, Wei Wang, Shujuan Li, Wenli Hu
Ischemic brain damage remains the major cause of death and disability worldwide. Bone mesenchymal stem cell (BMSC) transplantation has been identified to serve important roles in cerebral infarction due to its multi‑directional differentiation and proliferative ability. However, the function of miR‑705 combined with BMSCs on ischemic brain injury remains to be fully elucidated. In the present study, an ischemic brain injury mouse model was constructed, and the mice were injected with BMSCs infected by lentiviral particles expressing miR‑705 (BMSCs‑Ad‑miR‑705) to explore the mechanism by which BMSCs‑Ad‑miR‑705 mitigates neurological deficits in ischemic brain damage...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28974571/endothelial-mineralocorticoid-receptor-mediates-parenchymal-arteriole-and-posterior-cerebral-artery-remodeling-during-angiotensin-ii-induced-hypertension
#19
Janice M Diaz-Otero, Courtney Fisher, Kelsey Downs, M Elizabeth Moss, Iris Z Jaffe, William F Jackson, Anne M Dorrance
The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral perfusion. Mineralocorticoid receptor (MR) antagonism prevents hypertensive cerebral artery remodeling, but the vascular cell types involved have not been defined. In the periphery, the endothelial MR mediates hypertension-induced vascular injury, but cerebral and peripheral arteries are anatomically distinct; thus, these findings cannot be extrapolated to the brain...
December 2017: Hypertension
https://www.readbyqxmd.com/read/28969386/genetic-variants-influencing-elevated-myeloperoxidase-levels-increase-risk-of-stroke
#20
Chia-Ling Phuah, Tushar Dave, Rainer Malik, Miriam R Raffeld, Alison M Ayres, Joshua N Goldstein, Anand Viswanathan, Steven M Greenberg, Jeremiasz M Jagiella, Björn M Hansen, Bo Norrving, Jordi Jimenez-Conde, Jaume Roquer, Alexander Pichler, Christian Enzinger, Joan Montaner, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Reinhold Schmidt, Alessandro Biffi, Natalia Rost, Carl D Langefeld, Hugh S Markus, Braxton D Mitchell, Brad B Worrall, Steven J Kittner, Daniel Woo, Martin Dichgans, Jonathan Rosand, Christopher D Anderson
Primary intracerebral haemorrhage and lacunar ischaemic stroke are acute manifestations of progressive cerebral microvascular disease. Current paradigms suggest atherosclerosis is a chronic, dynamic, inflammatory condition precipitated in response to endothelial injury from various environmental challenges. Myeloperoxidase plays a central role in initiation and progression of vascular inflammation, but prior studies linking myeloperoxidase with stroke risk have been inconclusive. We hypothesized that genetic determinants of myeloperoxidase levels influence the development of vascular instability, leading to increased primary intracerebral haemorrhage and lacunar stroke risk...
October 1, 2017: Brain: a Journal of Neurology
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