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Keywords Cerebral vascular endothelial ...

Cerebral vascular endothelial injury

https://read.qxmd.com/read/38525134/protective-effect-of-cilostazol-on-vascular-injury-in-rats-with-acute-ischemic-stroke-complicated-with-chronic-renal-failure
#1
JOURNAL ARTICLE
Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Min
UNLABELLED: Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain...
April 2024: Toxicological Research
https://read.qxmd.com/read/38511722/high-frequency-repetitive-transcranial-magnetic-stimulation-promotes-ipsilesional-functional-hyperemia-and-motor-recovery-in-mice-with-ischemic-stroke
#2
JOURNAL ARTICLE
Li Liu, Ming Ding, Junfa Wu, Yuwen Zhang, Qianfeng Wang, Nianhong Wang, Lu Luo, Kewei Yu, Yunhui Fan, Jingjun Zhang, Yi Wu, Xiao Xiao, Qun Zhang
Neurovascular decoupling plays a significant role in dysfunction following an ischemic stroke. This study aimed to explore the effect of low- and high-frequency repetitive transcranial magnetic stimulation on neurovascular remodeling after ischemic stroke. To achieve this goal, we compared functional hyperemia, cerebral blood flow regulatory factors, and neurochemical transmitters in the peri-infract cortex 21 days after a photothrombotic stroke. Our findings revealed that low- and high-frequency repetitive transcranial magnetic stimulation increased the real-time cerebral blood flow in healthy mice and improved neurobehavioral outcomes after stroke...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38510579/fluid-biomarkers-of-the-neurovascular-unit-in-cerebrovascular-disease-and-vascular-cognitive-disorders-a-systematic-review-and-meta-analysis
#3
JOURNAL ARTICLE
Gurpreet Kaur Hansra, Tharusha Jayasena, Satoshi Hosoki, Anne Poljak, Ben Chun Pan Lam, Ruslan Rust, Abhay Sagare, Berislav Zlokovic, Anbupalam Thalamuthu, Perminder S Sachdev
BACKGROUND: The disruption of the neurovascular unit (NVU), which maintains the integrity of the blood brain barrier (BBB), has been identified as a critical mechanism in the development of cerebrovascular and neurodegenerative disorders. However, the understanding of the pathophysiological mechanisms linking NVU dysfunction to the disorders is incomplete, and reliable blood biomarkers to measure NVU dysfunction are yet to be established. This systematic review and meta-analysis aimed to identify biomarkers associated with BBB dysfunction in large vessel disease, small vessel disease (SVD) and vascular cognitive disorders (VCD)...
2024: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/38510106/5-ht-1f-receptor-agonism-induces-mitochondrial-biogenesis-and-increases-cellular-function-in-brain-microvascular-endothelial-cells
#4
JOURNAL ARTICLE
Natalie E Scholpa, Epiphani C Simmons, Austin D Thompson, Seth S Carroll, Rick G Schnellmann
INTRODUCTION: Vascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HT1F R) agonism induces mitochondrial biogenesis (MB) in multiple organ systems, including the CNS. METHODS: Lasmiditan is a selective 5-HT1F R agonist that is FDA-approved for the treatment of migraines...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38475929/amyloid-%C3%AE-oligomer-induces-cerebral-vasculopathy-via-pericyte-mediated-endothelial-dysfunction
#5
JOURNAL ARTICLE
Siqi Chen, Daji Guo, Yuanyuan Zhu, Songhua Xiao, Jiatian Xie, Zhan Zhang, Yu Hu, Jialin Huang, Xueying Ma, Zhiyuan Ning, Lin Cao, Jinping Cheng, Yamei Tang
BACKGROUND: Although abnormal accumulation of amyloid beta (Aβ) protein is thought to be the main cause of Alzheimer's disease (AD), emerging evidence suggests a pivotal vascular contribution to AD. Aberrant amyloid β induces neurovascular dysfunction, leading to changes in the morphology and function of the microvasculature. However, little is known about the underlying mechanisms between Aβ deposition and vascular injuries. Recent studies have revealed that pericytes play a substantial role in the vasculopathy of AD...
March 12, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38452844/cerebral-endothelial-cells-mediated-enhancement-of-brain-pericyte-number-and-migration-in-oxygen-glucose-deprivation-involves-the-hif-1%C3%AE-pdgf-%C3%AE-signaling
#6
JOURNAL ARTICLE
Shi-Na Song, Wen-Ping Dong, Xin-Xin Dong, Fang Guo, Lin Ren, Chang-Xin Li, Jian-Ming Wang
The present study focused on whether hypoxia-inducible factor-1alpha (HIF-1α) and platelet-derived factor-beta (PDGF-β) are involved in the crosstalk between brain microvascular endothelial cells (BMECs) and brain vascular pericytes (BVPs) under ischaemic-hypoxic conditions. Mono-cultures or co-cultures of BVPs and BMECs were made for the construction of the blood-brain barrier (BBB) model in vitro and then exposed to control and oxygen-glucose deprivation (OGD) conditions. BBB injury was determined by assessing the ability, apoptosis, and migration of BVPs and the transendothelial electrical resistance and horseradish peroxidase permeation of BMECs...
March 5, 2024: Brain Research
https://read.qxmd.com/read/38421088/activation-of-testosterone-androgen-receptor-mediates-cerebrovascular-protection-by-photobiomodulation-treatment-in-photothrombosis-induced-stroke-rats
#7
JOURNAL ARTICLE
Yu Feng, Zhihai Huang, Xiaohui Ma, Xuemei Zong, Celeste Yin-Chieh Wu, Reggie Hui-Chao Lee, Hung Wen Lin, Michael R Hamblin, Quanguang Zhang
RATIONALE: Numerous epidemiological studies have reported a link between low testosterone levels and an increased risk of cerebrovascular disease in men. However, there is ongoing controversy surrounding testosterone replacement therapy due to potential side effects. PBMT has been demonstrated to improve cerebrovascular function and promote testosterone synthesis in peripheral tissues. Despite this, the molecular mechanisms that could connect PBMT with testosterone and vascular function in the brain of photothrombosis (PT)-induced stroke rats remain largely unknown...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38417710/blood-based-biomarkers-of-cerebral-small-vessel-disease
#8
REVIEW
Liu-Yun Wu, Yuek Ling Chai, Irwin K Cheah, Rachel S L Chia, Saima Hilal, Thiruma V Arumugam, Christopher P Chen, Mitchell K P Lai
Age-associated cerebral small vessel disease (CSVD) represents a clinically heterogenous condition, arising from diverse microvascular mechanisms. These lead to chronic cerebrovascular dysfunction and carry a substantial risk of subsequent stroke and vascular cognitive impairment in aging populations. Owing to advances in neuroimaging, in vivo visualization of cerebral vasculature abnormities and detection of CSVD, including lacunes, microinfarcts, microbleeds and white matter lesions, is now possible, but remains a resource-, skills- and time-intensive approach...
March 2024: Ageing Research Reviews
https://read.qxmd.com/read/38403349/-tetramethylpyrazine-regulates-angiogenesis-of-endothelial-cells-in-cerebral-ischemic-stroke-injury-via-sirt1-vegfa-signaling-pathway
#9
JOURNAL ARTICLE
Meng-Qi Shu, Yao-Yao Dai, Li-Juan Song, Dong Ma, Ke-Xin Liu, Zhu-Yue Miao, Ru-Heng Wei, Jin-Zhu Yin, Cun-Gen Ma, Jian-Jun Huang
This study aims to investigate whether tetramethylpyrazine(TMP) can stimulate angiogenesis in cerebral microvascular endothelial cells and alleviate cerebral ischemic stroke(CIS) and to explore the underlying mechanisms. In the animal study, adult Sprague-Dawley rats(n=15) were assigned into sham surgery(sham), middle cerebral artery occlusion/reperfusion(MCAO/R), and MCAO/R+TMP(intraperitoneal injection of 20 mg·kg~(-1)) groups. The neurological function was evaluated by the Z-Longa method. The cerebral infarction volume was detected by TTC staining...
January 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38382829/vascular-stent-with-immobilized-anti-inflammatory-chemerin-15-peptides-mitigates-neointimal-hyperplasia-and-accelerates-vascular-healing
#10
REVIEW
Lan Wen, Hua Qiu, Shuang Li, Yan Huang, Qiufen Tu, Nan Lyu, Xiaohui Mou, Xia Luo, Jinyu Zhou, Yin Chen, Chaohua Wang, Nan Huang, Jianguo Xu
Endovascular stenting is a safer alternative to open surgery for use in treating cerebral arterial stenosis and significantly reduces the recurrence of ischemic stroke, but the widely used bare-metal stents (BMSs) often result in in-stent restenosis (ISR). Although evidence suggests that drug-eluting stents are superior to BMSs in the short term, their long-term performances remain unknown. Herein, we propose a potential vascular stent modified by immobilizing clickable chemerin 15 (C15) peptides on the stent surface to suppress coagulation and restenosis...
February 19, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38380477/advanced-age-and-female-sex-protect-cerebral-arteries-from-mitochondrial-depolarization-and-apoptosis-during-acute-oxidative-stress
#11
JOURNAL ARTICLE
Charles E Norton, Rebecca L Shaw, Safa, Beyoncé Dockery, Timothy L Domeier, Steven S Segal
Aging increases reactive oxygen species (ROS) which can impair vascular function and contribute to brain injury. However, aging can also promote resilience to acute oxidative stress. Therefore, we tested the hypothesis that advanced age protects smooth muscle cells (SMCs) and endothelial cells (ECs) of posterior cerebral arteries (PCAs; diameter, ∼80 μm) during exposure to H2 O2 . PCAs from young (4-6 months) and old (20-26 months) male and female C57BL/6 mice were isolated and pressurized (~70 mm Hg) to evaluate cell death, mitochondrial membrane potential (ΔΨm ), ROS production, and [Ca2+ ]i in response to H2 O2 (200 μM, 50 min)...
February 21, 2024: Aging Cell
https://read.qxmd.com/read/38379112/advancing-stroke-therapy-a-deep-dive-into-early-phase-of-ischemic-stroke-and-recanalization
#12
REVIEW
Qianyan He, Yueqing Wang, Cheng Fang, Ziying Feng, Meifang Yin, Juyang Huang, Yinzhong Ma, Zhizhun Mo
Ischemic stroke, accounting for the majority of stroke events, significantly contributes to global morbidity and mortality. Vascular recanalization therapies, namely intravenous thrombolysis and mechanical thrombectomy, have emerged as critical interventions, yet their success hinges on timely application and patient-specific factors. This review focuses on the early phase pathophysiological mechanisms of ischemic stroke and the nuances of recanalization. It highlights the dual role of neutrophils in tissue damage and repair, and the critical involvement of the blood-brain barrier (BBB) in stroke outcomes...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38362345/clonal-expansion-in-cardiovascular-pathology
#13
REVIEW
Alexander Lin, Mairi Brittan, Andrew H Baker, Stefanie Dimmeler, Edward A Fisher, Judith C Sluimer, Ashish Misra
Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding of cell clonality in the cardiovascular context. However, our knowledge of the underlying mechanisms behind this clonal selection is still severely limited. There is a transpiring pattern of clonal expansion of smooth muscle cells and endothelial cells-and, in some cases, macrophages-in numerous cardiovascular diseases irrespective of their differing microenvironments...
January 2024: JACC. Basic to Translational Science
https://read.qxmd.com/read/38341077/canagliflozin-protects-against-hyperglycemia-induced-cerebrovascular-injury-by-preventing-blood-brain-barrier-bbb-disruption-via-ampk-sp1-adenosine-a2a-receptor
#14
JOURNAL ARTICLE
Zhiyi Liu, Wei Hua, Sinan Jin, Yueying Wang, Yuxin Pang, Benshuai Wang, Nan Zhao, Jiping Qi, Yuejia Song
Diabetes mellitus causes brain microvascular endothelial cell (MEC) damage, inducing dysfunctional angiogenic response and disruption of the blood-brain barrier (BBB). Canagliflozin is a revolutionary hypoglycemic drug that exerts neurologic and/or vascular-protective effects beyond glycemic control; however, its underlying mechanism remains unclear. In the present study, we hypothesize that canagliflozin ameliorates BBB permeability by preventing diabetes-induced brain MEC damage. Mice with high-fat diet/streptozotocin-induced diabetes received canagliflozin for 8 weeks...
February 8, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38331020/vegf-overexpression-in-transplanted-nscs-promote-recovery-of-neurological-function-in-rats-with-cerebral-ischemia-by-modulating-the-wnt-signal-transduction-pathway
#15
JOURNAL ARTICLE
Yizhen Zhu, Ruojing Liu, Xue Zhao, Chaosheng Kang, Dan Yang, Guo Ge
Neural stem cell transplantation is a good method to treat stroke, but the mechanism is still unclear. Therefore, this study aims to explore the regulatory mechanism of VEGF overexpression in transplanted NSCs to promote the recovery of neural function in ischemic rats by regulating Wnt signal transduction pathways. We amplified VEGF gene fragments by PCR and transfected them into NSCs with Ad5 adenovirus. Rat brain IRI model was established by MCAO method, and VEGF transfected NSCs (VEGF-NSCs) were transplanted 24 h after successful IRI model...
February 6, 2024: Neuroscience Letters
https://read.qxmd.com/read/38322523/-mechanobiological-mechanisms-involved-in-the-regualation-of-the-blood-brain-barrier-by-fluid-shear-force
#16
JOURNAL ARTICLE
Lingyu DU, Bowen Xu, Lin Cheng, Hongyan Yue, Huaiyi Zhang, Yang Shen
OBJECTIVE: To explore the mechanobiological mechanism of fluid shear force (FSF) on the protection, injury, and destruction of the structure and function of the blood-brain barrier (BBB) under normal physiological conditions, ischemic hypoperfusion, and postoperative hyperperfusion conditions. BBB is mainly composed of brain microvascular endothelial cells. Rat brain microvascular endothelial cells (rBMECs) were used as model cells to conduct the investigation. METHODS: rBMECs were seeded at a density of 1×105 cells/cm2 and incubated for 48 h...
January 20, 2024: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://read.qxmd.com/read/38306519/endothelial-marker-profiles-in-cerebral-radiation-induced-vasculopathy-a-comparative-immunohistochemical-analysis
#17
JOURNAL ARTICLE
Mohammad Mohsen Mosleh, Moon-Jun Sohn, Han Seong Kim
Radiation therapy results in radiation-induced vasculopathy, characterized by alterations in the vascular architecture stemming from radiation exposure. The exact molecular pathways and associated pathologies of this condition have yet to be comprehensively understood. This study aimed to identify specific markers' roles in cerebral vascular endothelial injury pathogenesis after radiosurgery and explore their unique expression patterns in diverse pathologies post-stereotactic radiosurgery. A retrospective cohort study was conducted to assess the expression profiles of endothelial markers via immunohistochemical analysis in 25 adult patients (13 males and 12 females) who had undergone neurosurgical resection for various central nervous system pathologies following stereotactic radiosurgery or radiotherapy from 2001 to 2015...
February 2, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38287311/enhanced-meningeal-lymphatic-drainage-ameliorates-lipopolysaccharide-induced-brain-injury-in-aged-mice
#18
JOURNAL ARTICLE
Hongquan Dong, Xiaonan Dai, Yin Zhou, Chonglong Shi, Piplu Bhuiyan, Zhaochu Sun, Nana Li, Wenjie Jin
BACKGROUND: Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction caused by sepsis. Neuroinflammation induced by sepsis is considered a potential mechanism of SAE; however, very little is known about the role of the meningeal lymphatic system in SAE. METHODS: Sepsis was established in male C57BL/6J mice by intraperitoneal injection of 5 mg/kg lipopolysaccharide, and the function of meningeal lymphatic drainage was assessed. Adeno-associated virus 1-vascular endothelial growth factor C (AAV1-VEGF-C) was injected into the cisterna magna to induce meningeal lymphangiogenesis...
January 30, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38286334/new-insight-on-the-possible-role-of-statins-in-vascular-parkinsonism-a-need-for-presumptive-therapy
#19
REVIEW
Hayder M Al-Kuraishy, Majid S Jabir, Ali I Al-Gareeb, Ali K Albuhadily
Vascular Parkinsonism (VP) is clinical term represents a progressive ischemic changes and subcortical lacunar infarct leading to Parkinsonism mainly in the lower limbs so called lower body Parkinsonism. The VP neuropathology is differed from that of PD neuropathology which rarely associated with basal ganglion lesions. Dopamine transporters are normal in VP but are highly reduced in PD, and dopaminergic agonists had no effective role on VP. The neuropathological mechanisms of VP are related to vascular injury which induces the interruption of the neural connection between basal ganglion and cerebral cortex...
January 28, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38261283/-traumatic-brain-injury-as-risk-factor-of-alzheimer-s-disease-and-possibilities-of-pathogenetic-therapy
#20
JOURNAL ARTICLE
I V Litvinenko, K M Naumov, V Yu Lobzin, A Yu Emelin, P S Dynin, K A Kolmakova, V O Nikishin
The article examines the potential role of brain mechanical damage as a trigger for the development of neurodegenerative changes. Attention is paid to dysfunction of the neurovascular unit, and disruption of the functional and compensatory capabilities of blood flow. The importance of microhemorrhages that occur in the acute period of injury and the formation of first focal and then diffuse neuroinflammation is emphasized. The importance of mitochondrial dysfunction was separately determined as a significant factor in increasing the risk of developing Alzheimer's disease (AD) in patients after traumatic brain injury (TBI)...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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