keyword
MENU ▼
Read by QxMD icon Read
search

Markers of endothelial injury

keyword
https://www.readbyqxmd.com/read/27902983/perinatal-asphyxia-and-erythropoietin-and-vegf-serial-serum-and-cerebrospinal-fluid-responses
#1
Deirdre U Sweetman, Chike Onwuneme, William R Watson, John F A Murphy, Eleanor J Molloy
BACKGROUND: Infants with neonatal encephalopathy (NE) of hypoxic-ischaemic origin are at risk of oxidative and ischaemia-reperfusion injury, which may induce abnormal inflammatory responses involving excessive cytokine production and release in serum and cerebrospinal fluid (CSF). Systemic inflammation is found in infants with NE, and we therefore were interested in cytokines associated with hypoxia, including vascular endothelial growth factor (VEGF) and erythropoietin (Epo). OBJECTIVE: To investigate the relationship between Epo, VEGF levels, brain injury and outcome in a group of term infants exposed to perinatal asphyxia (PA) compared to controls...
December 1, 2016: Neonatology
https://www.readbyqxmd.com/read/27881939/can-pregnancy-associated-plasma-protein-a-be-a-marker-for-the-assessment-of-atherosclerosis-risk-in-patients-with-chronic-plaque-psoriasis
#2
Mualla Polat, Guler Bugdayci, Asli Sahin, Hatice Kaya, Tuna Sezer, Serkan Ozturk
INTRODUCTION: Psoriasis is an immune-mediated chronic inflammatory dermatosis. Several studies have shown that patients with psoriasis have a much greater risk of cardiovascular diseases than the normal population. The chronic inflammation observed in psoriasis is thought to have a role in the development of atherosclerosis and vascular endothelial injury. AIM: To examine serum pregnancy-associated plasma protein-A (PAPP-A) levels, which has been regarded as a marker of early stage atherosclerosis in patients with psoriasis that do not have concurrent conventional cardiovascular risk markers...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27865159/dietary-glutamine-supplementation-enhances-endothelial-progenitor-cell-mobilization-in-streptozotocin-induced-diabetic-mice-subjected-to-limb-ischemia
#3
Shiau-Tsz Su, Chiu-Li Yeh, Yu-Chen Hou, Man-Hui Pai, Sung-Ling Yeh
Diabetes is a metabolic disorder with increased risk of vascular diseases. Tissue ischemia may occur with diabetic vascular complications. Bone marrow-derived endothelial progenitor cells (EPCs) constitute a reparative response to ischemic injury. This study investigated the effects of oral glutamine (GLN) supplementation on circulating EPC mobilization and expression of tissue EPC-releasing markers in diabetic mice subjected to limb ischemia. Diabetes was induced by a daily intraperitoneal injection of streptozotocin for 5 days...
October 29, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27846156/plasma-c4d-endothelial-microvesicles-increase-in-acute-antibody-mediated-rejection
#4
Cindy M Tower, Morayma Reyes, Karen Nelson, Nicolae Leca, Niamh Kieran, Kimberly Muczynski, Jonathan A Jefferson, Christopher Blosser, Aleksandra Kukla, David Maurer, Wayne Chandler, Behzad Najafian
BACKGROUND: Antibody mediated rejection (AMR) is a major cause of kidney allograft loss. Currently, AMR diagnosis relies on biopsy which is an invasive procedure. A noninvasive biomarker of acute AMR could lead to early diagnosis and treatment of this condition and improve allograft outcome. Microvesicles are membrane bound vesicles released from the cell surface following injury. We hypothesized that since AMR is associated with allograft endothelial injury and C4d deposition, plasma microvesicles positive for endothelial (CD144) marker and C4d are increased in this condition...
November 15, 2016: Transplantation
https://www.readbyqxmd.com/read/27844250/differential-response-of-human-cardiac-stem-cells-and-bone-marrow-mesenchymal-stem-cells-to-hypoxia-reoxygenation-injury
#5
Deepthi Sreerengam RajendranNair, Jayakumar Karunakaran, Renuka R Nair
Cardiosphere-derived cells (CDCs) and bone marrow mesenchymal stem cells (MSCs) are popularly used in stem cell therapy for myocardial regeneration. The cell type that survives and maintains stem cell characteristics in the adverse microenvironment following ischemia-reperfusion injury is presumed to be ideal for transplantation. The study was therefore aimed at identifying the cell type with relatively greater resistance to ischemia-reperfusion injury. CDCs were isolated from the right atrial appendage and MSCs from bone marrow of patients who underwent coronary artery bypass graft surgery...
November 14, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27834190/differentiated-smooth-muscle-cells-generate-a-subpopulation-of-resident-vascular-progenitor-cells-in-the-adventitia-regulated-by-klf4
#6
Mark W Majesky, Henrick Horita, Allison Ostriker, Sizhao Lu, Jenna N Regan, Ashim K Bagchi, Xiu R Dong, Joanna M Poczobutt, Raphael A Nemenoff, Mary C Weiser-Evans
RATIONALE: The vascular adventitia is a complex layer of the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells. Adventitial progenitors express the stem cell markers, Sca1 and CD34 (AdvSca1 cells), have the potential to differentiate in vitro into multiple lineages, and potentially contribute to intimal lesions in vivo. OBJECTIVE: While emerging data support the existence of AdvSca1 cells, the goal of this study was to determine their origin, degree of multipotency and/or heterogeneity, and contribution to vessel remodeling...
November 9, 2016: Circulation Research
https://www.readbyqxmd.com/read/27825158/regeneration-of-the-aging-lung-a-mini-review
#7
Sonia Navarro, Barbara Driscoll
Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. Aging strongly correlates with the development and incidence of chronic respiratory diseases, including cancer and idiopathic pulmonary fibrosis, but is most strongly linked with development of chronic obstructive pulmonary disease...
November 9, 2016: Gerontology
https://www.readbyqxmd.com/read/27824721/antiperoxynitrite-treatment-ameliorates-vasorelaxation-of-resistance-arteries-in-aging-rats-involvement-with-protection-of-circulating-endothelial-progenitor-cells
#8
Qi Sun, Yu Dong, Huanyuan Wang, Kun Jiao, Jiahui Xu, Lu Ma, Haixia Huang, Huirong Liu, Wen Wang
Numerous studies have found that the age-associated structural and functional alterations in arteries were characterized by increased endothelial dysfunction. In this study, young (3 months), adult (9 months), and aging (20 months) male Sprague-Dawley rats were randomly divided into 6 groups, including control groups and FeTMPyP (peroxynitrite scavenger) groups receiving saline and FeTMPyP, respectively, for 5 administrations once every 3 days through intraperitoneal injection. The aged-related proteins beta-galactosidase, p53, and p16 as well as the nitrotyrosine and endothelial marker endothelial nitric oxide synthase and von Willebrand factor (vWF) in vascular tissues were measured by immunohistochemistry...
November 2016: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/27824430/dietary-fructose-induced-hepatic-injury-in-male-and-female-rats-influence-of-resveratrol
#9
M B Pektas, G Yücel, H B Koca, G Sadi, O G Yıldırım, G Öztürk, F Akar
Purpose: Relatively little is known about gender-dependent susceptibility to hepatic injury induced by nutritional factors. In the current study, we investigated dietary fructose-induced hepatic degeneration and roles of endothelial nitric oxide synthase (eNOS), insulin receptor (IRβ) and substrate-1 (IRS-1) expressions in association with inflammatory markers in male and female rats. Moreover, we examined potential effect of resveratrol on fructose-induced changes. Methods: Male and female rats were divided into 4 groups as control, resveratrol, fructose and resveratrol plus fructose...
November 7, 2016: Drug Research
https://www.readbyqxmd.com/read/27823723/chitinase-3-like-protein-1-ykl-40-as-a-marker-of-endothelial-dysfunction-in-obstructive-sleep-apnea
#10
Behrouz Jafari, Vahid Mohsenin
BACKGROUND: Obstructive sleep apnea (OSA) is a highly prevalent disorder affecting 15-24% of adults and triples the risk for hypertension independent of other risk factors. The exact mechanisms of endothelial dysfunction and variable susceptibility to hypertension in OSA are not entirely clear. No biomarker to date has been found to be associated with hypertension in OSA. Chitinase-3-like protein-1(YKL-40) is a circulating moiety with roles in injury, repair and angiogenesis that is dysregulated in atherosclerosis and correlates with increased cardiovascular morbidity and mortality...
September 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27785026/amorphous-silica-nanoparticles-trigger-vascular-endothelial-cell-injury-through-apoptosis-and-autophagy-via-reactive-oxygen-species-mediated-mapk-bcl-2-and-pi3k-akt-mtor-signaling
#11
Caixia Guo, Man Yang, Li Jing, Ji Wang, Yang Yu, Yang Li, Junchao Duan, Xianqing Zhou, Yanbo Li, Zhiwei Sun
Environmental exposure to silica nanoparticles (SiNPs) is inevitable due to their widespread application in industrial, commercial, and biomedical fields. In recent years, most investigators focus on the evaluation of cardiovascular effects of SiNPs in vivo and in vitro. Endothelial injury and dysfunction is now hypothesized to be a dominant mechanism in the development of cardiovascular diseases. This study aimed to explore interaction of SiNPs with endothelial cells, and extensively investigate the exact effects of reactive oxygen species (ROS) on the signaling molecules and cytotoxicity involved in SiNPs-induced endothelial injury...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27780829/exposure-to-fine-particulate-air-pollution-is-associated-with-endothelial-injury-and-systemic-inflammation
#12
C A Pope, Aruni Bhatnagar, James McCracken, Wesley T Abplanalp, Daniel J Conklin, Timothy E O'Toole
RATIONALE: Epidemiologic evidence indicates that exposures to fine particulate matter air pollution (PM2.5) contribute to global burden of disease, primarily as a result of increased risk of cardiovascular morbidity and mortality. However, mechanisms by which PM2.5 exposure induces cardiovascular injury remain unclear. PM2.5-induced endothelial dysfunction and systemic inflammation have been implicated, but direct evidence is lacking. OBJECTIVE: To examine whether acute exposure to PM2...
October 25, 2016: Circulation Research
https://www.readbyqxmd.com/read/27780127/highly-sensitive-turn-on-fluorescence-detection-of-thrombomodulin-based-on-fluorescence-resonance-energy-transfer
#13
Liyan Kong, Jiaming Zhu, Wen Wang, Lehe Jin, Yanjiao Fu, Bohui Duan, Liang Tan
As an integral glycoprotein on the surface of endothelial cells, thrombomodulin (TM) has very high affinity for thrombin. TM has been regarded to be a marker of endothelial damage since it can be released during endothelial cell injury. In this work, a highly sensitive fluorescence method for the quantitative detection of TM was developed. TM antibody (Ab) and bovine serum albumin (BSA) were bound on gold nanoparticles (AuNPs) to construct BSA-AuNPs-Ab nanocomposites and they were characterized by transmission electron microscope and UV-vis spectrophotometry...
October 17, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27779706/effect-of-colorectal-cancer-on-the-number-of-normal-stem-cells-circulating-in-peripheral-blood
#14
Wojciech Marlicz, Katarzyna Sielatycka, Karol Serwin, Ewa Kubis, Marta Tkacz, Rafał Głuszko, Andrzej Białek, Teresa Starzyńska, Mariusz Z Ratajczak
Bone marrow (BM) residing stem cells are mobilized from their BM niches into peripheral blood (PB) in several pathological situations including tissue organ injury and systemic inflammation. We recently reported that the number of BM-derived stem cells (SCs) increases in patients with pancreatic and stomach cancer. Accordingly, we observed higher numbers of circulating very small embryonic/epiblast‑like stem cells (VSELs) and mesenchymal stem cells (MSCs) that were associated with the activation of pro-mobilizing complement cascade and an elevated level of sphingosine-1 phosphate (S1P) in PB plasma...
October 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27777141/angiogenic-factors-correlate-with-t-cell-immune-reconstitution-and-clinical-outcomes-after-double-unit-umbilical-cord-blood-transplantation-in-adults
#15
Ioannis Politikos, Haesook Kim, Theodoros Karantanos, Julia Brown, Sean McDonough, Lequn Li, Corey Cutler, Joseph H Antin, Karen K Ballen, Jerome Ritz, Vassiliki A Boussiotis
Umbilical cord blood (UCB) is a valuable graft source for allogeneic hematopoietic stem cell transplantation (HSCT) in patients who lack adult donors. UCB transplantation (UCBT) in adults results in delayed immune reconstitution, leading to high infection-related morbidity and mortality. Angiogenic factors and markers of endothelial dysfunction have biologic and prognostic significance in conventional HSCT, but their role in UCBT has not been investigated. Furthermore, the interplay between angiogenesis and immune reconstitution has not been studied...
October 21, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27761886/comparison-between-effects-of-pressure-support-and-pressure-controlled-ventilation-on-lung-and-diaphragmatic-damage-in-experimental-emphysema
#16
Gisele de A Padilha, Lucas F B Horta, Lillian Moraes, Cassia L Braga, Milena V Oliveira, Cíntia L Santos, Isalira P Ramos, Marcelo M Morales, Vera Luiza Capelozzi, Regina C S Goldenberg, Marcelo Gama de Abreu, Paolo Pelosi, Pedro L Silva, Patricia R M Rocco
BACKGROUND: In patients with emphysema, invasive mechanical ventilation settings should be adjusted to minimize hyperinflation while reducing respiratory effort and providing adequate gas exchange. We evaluated the impact of pressure-controlled ventilation (PCV) and pressure support ventilation (PSV) on pulmonary and diaphragmatic damage, as well as cardiac function, in experimental emphysema. METHODS: Emphysema was induced by intratracheal instillation of porcine pancreatic elastase in Wistar rats, once weekly for 4 weeks...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27756187/endocan-and-albuminuria-in-type-2-diabetes-mellitus
#17
Mehmet Ali Cikrikcioglu, Zeynep Erturk, Elif Kilic, Kenan Celik, Iskender Ekinci, Ayse Irem Yasin Cetin, Tuba Ozkan, Guven Cetin, Shute Ailia Dae, Rumeyza Kazancioglu, Reha Erkoc
BACKGROUND: Endocan is a newly identified proteoglycan released from endothelium, stimulating angiogenesis and when increased, indicates endothelial activation (inflammation). Our aim was to examine the association between serum endocan levels and urine albumin-creatinine ratio (UACR). METHOD: One hundred and thirty-seven patients with type 2 diabetes mellitus and normal serum creatinine who had no co-morbidities other than hypertension, diabetic nephropathy, retinopathy, or neuropathy were divided into normoalbuminuria (G1), microalbuminuria (G2), and macroalbuminuria (G3) groups and compared cross-sectionally regarding serum endocan levels...
October 18, 2016: Renal Failure
https://www.readbyqxmd.com/read/27753903/os-02-03-effect-of-high-glucose-exposure-on-endothelial-microparticle-formation-and-composition
#18
Maddison Turner, Larissa Reid, Mercedes Munkonda, Dylan Burger
OBJECTIVE: Diabetes and hypertension are cognate diseases that often coexist, potentiating one's risk for cardiovascular complications. Both diseases are typified by the development of endothelial dysfunction and are accompanied by increased circulating endothelial microparticles (eMPs). Microparticles are small membrane-derived vesicles that are secreted ubiquitously following cell stress. We have previously shown that eMPs are sensitive markers of vascular injury in hypertension and identified eMP-mediated signaling pathways that lead to endothelial injury...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27747196/shiga-toxin-mediated-neurologic-changes-in-murine-model-of-disease
#19
Suman Pradhan, Christine Pellino, Kayleigh MacMaster, Dennis Coyle, Alison A Weiss
Seizures and neurologic involvement have been reported in patients infected with Shiga toxin (Stx) producing E. coli, and hemolytic uremic syndrome (HUS) with neurologic involvement is associated with more severe outcome. We investigated the extent of renal and neurologic damage in mice following injection of the highly potent form of Stx, Stx2a, and less potent Stx1. As observed in previous studies, Stx2a brought about moderate to acute tubular necrosis of proximal and distal tubules in the kidneys. Brain sections stained with hematoxylin and eosin (H&E) appeared normal, although some red blood cell congestion was observed...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27729946/status-of-stem-cells-in-diabetic-nephropathy-predictive-and-preventive-potentials
#20
Babak Baban, Jun Yao Liu, Samuel Payne, Worku Abebe, Jack C Yu, Mahmood S Mozaffari
BACKGROUND: Recruitment of stem cells to sites of tissue injury constitutes an important mechanism aimed at tissue repair and regeneration. However, it is not clear how the diabetic milieu affects the viability of endogenous stem cells. Thus, we tested the hypothesis that diabetes mellitus is associated with increased apoptosis which, in turn, contributes to reduction in stem cells and the manifestation of type 2 diabetic nephropathy. METHODS: Sixteen-week-old male obese type 2 diabetic db/db mice, and their appropriate controls, were used for assessment of the status of endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), and hematopoetic stem cells (HSCs) in the peripheral blood and renal tissue using specific cell markers...
2016: EPMA Journal
keyword
keyword
21304
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"