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Circulatory biomarker of endothelial damage

Fan Deng, Shuang Wang, Liangqing Zhang
Circulatory hypoxia-related diseases (CHRDs), including acute coronary syndromes, stroke and organ transplantation, attract increased attention due to high morbidity and mortality. Mounting evidence shows that hypoxia-induced oxidative stress, coagulation, inflammation and angiogenesis play extremely important roles in the physiological and pathological processes of CHRD-related vascular endothelial injury. Interestingly, hypoxia, even hypoxia-induced oxidative stress, coagulation and inflammation can all induce release of endothelial microparticles (EMPs)...
September 2017: Journal of Cellular and Molecular Medicine
E Maffioli, F Aletti, S Nonnis, F Santagata, A Negri, F A DeLano, M H Santamaria, E B Kistler, G W Schmid-Schönbein, G Tedeschi
INTRODUCTION: Circulatory shock is a frequent cause of death and a most important unresolved medical problem. Reduction of blood supply to the intestine during ischemia disrupts the mucosal epithelial barrier allowing inflammatory materials in the lumen of the intestine, including digestive enzymes, to cross the intestinal wall (Fig. 1). The transport of digestive enzymes leads to uncontrolled digestive enzyme activity in the circulation, which generates cell/tissue damage and a strong inflammatory reaction...
October 2015: Shock
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