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Circulatory biomarker of endothelial damage

E Maffioli, F Aletti, S Nonnis, F Santagata, A Negri, F A DeLano, M H Santamaria, E B Kistler, G W Schmid-Schönbein, G Tedeschi
INTRODUCTION: Circulatory shock is a frequent cause of death and a most important unresolved medical problem. Reduction of blood supply to the intestine during ischemia disrupts the mucosal epithelial barrier allowing inflammatory materials in the lumen of the intestine, including digestive enzymes, to cross the intestinal wall (Fig. 1). The transport of digestive enzymes leads to uncontrolled digestive enzyme activity in the circulation, which generates cell/tissue damage and a strong inflammatory reaction...
October 2015: Shock
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