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Body response to free radicals

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https://www.readbyqxmd.com/read/28539682/the-human-body-as-an-energetic-hybrid-new-perspectives-for-chronic-disease-treatment
#1
REVIEW
Michał Gajewski, Przemysław Rzodkiewicz, Sławomir Maśliński
Inflammatory response is accompanied by changes in cellular energy metabolism. Proinflammatory mediators like plasma C-reactive protein, IL-6, plasminogen activator inhibitor-1, TNF-α or monocyte chemoattractant protein-1 released in the site of inflammation activates immune cells and increase energy consumption. Increased demand for energy creates local hypoxia and lead in consequence to mitochondrial dysfunction. Metabolism of cells is switched to anaerobic glycolysis. Mitochondria continuously generate free radicals that what result in imbalance that causes oxidative stress, which results in oxidative damage...
2017: Reumatologia
https://www.readbyqxmd.com/read/28525944/oxidative-stress-and-some-biochemical-alterations-due-to-scorpion-leiurus-quinquestriatus-crude-venom-in-rats
#2
Muhammad M A Salman, Seddik Hammad
Scorpion envenomation is a common medical problem in many countries; it is an important cause of morbidity and mortality. The venom of Leiurus quinquestriatus (LQ) is responsible for a number of deaths in children and adults. It has been stated that specific pathophysiological conditions such as generation of oxygen free radicals may trigger the onset of multiple organ dysfunction; therefore, the present study aimed to assess the oxidative stress mediated by LQ crude venom and its effect on the biochemical parameters in rats...
May 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28521709/modulation-of-inflammatory-response-to-implanted-biomaterials-using-natural-compounds
#3
Maria Yanez, James Blanchette, Ehsan Jabbarzadeh
Tissue engineering offers a promising strategy to restore injuries resulting from trauma, infection, tumor resection, or other diseases. In spite of significant progress, the field faces a significant bottleneck; the critical need to understand and exploit the interdependencies of tissue healing, angiogenesis, and inflammation. Inherently, the balance of these interacting processes is affected by a number of injury site conditions that represent a departure from physiological environment, including reduced pH, increased concentration of free radicals, hypoglycemia, and hypoxia...
May 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28490331/quantifying-capture-stress-in-free-ranging-european-roe-deer-capreolus-capreolus
#4
Nikolaus Huber, Sebastian G Vetter, Alina L Evans, Petter Kjellander, Susanne Küker, Ulrika A Bergvall, Jon M Arnemo
BACKGROUND: To understand and reduce the concomitant effects of trapping and handling procedures in wildlife species, it is essential to measure their physiological impact. Here, we examined individual variation in stress levels in non-anesthetized European roe deer (Capreolus capreolus), which were captured in box traps and physically restrained for tagging, biometrics and bio-sampling. In winter 2013, we collected venous blood samples from 28 individuals during 28 capture events and evaluated standard measurements for stress (heart rate, body temperature, neutrophil to lymphocyte ratio, lactate and total cortisol)...
May 10, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28489094/theoretical-insights-into-the-mechanism-of-ferroptosis-suppression-via-inactivation-of-a-lipid-peroxide-radical-by-liproxstatin-1
#5
Xiehuang Sheng, Chao Shan, Jianbiao Liu, Jintong Yang, Bin Sun, Dezhan Chen
Ferroptosis is a recently discovered iron-dependent form of non-apoptotic cell death caused by the accumulation of membrane lipid peroxidation products, which is involved in various pathological conditions of the brain, kidney, liver and heart. A potent spiroquinoxalinamine derivative named liproxstatin-1 is discovered by high-throughput screening, which is able to suppress ferroptosis via lipid peroxide scavenging in vivo. Thus, molecular simulations, density functional theory (DFT) and variational transition-state theory with a small-curvature tunneling (SCT) coefficient are utilized to elucidate the detailed mechanisms of inactivation of a lipid peroxide radical by liproxstatin-1...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28482523/switchable-on-off-drug-release-from-gold-nanoparticles-grafted-dual-light-and-temperature-responsive-hydrogel-for-controlled-drug-delivery
#6
Mitra Amoli-Diva, Rasoul Sadighi-Bonabi, Kamyar Pourghazi
A switchable dual light- and temperature-responsive drug carrier using gold nanoparticles (Au NPs)-grafted poly(dimethylacrylamide-co-acrylamide)/poly acrylic acid [P(DMA-co-AAm)/PAAc] hydrogel was prepared by free radical polymerization procedure using N,N-methylenebisacrylamide as cross-linker and ammonium persulfate as initiator. Initial P(DMA-co-AAm) hydrogel and uniformly-distributed stable Au NPs, prepared by reduction of hydrogen tetrachloroaureate (III) hydrate in the presence of trisodium citrate, were synthesized separately...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28445896/total-serum-antioxidant-capacity-in-healthy-normal-weight-and-asymptomatic-overweight-adults
#7
Ana Petelin, Paola Tedeschi, Annalisa Maietti, Mihaela Jurdana, Vincenzo Brandolini, Zala Jenko Pražnikar
Obesity and overweight are major contributors to the burden of chronic disease. Both are defined as abnormal or excessive fat accumulation and by increased production of free radicals leading to oxidative stress. The aim of the present study was to evaluate whether overweight and fat accumulation is associated with serum total antioxidant capacity (TAC) in men and women, irrespective of nutritional habits, nutrient intakes, physical activity, smoking, and other confounders, which may be responsible for modifying the association between serum TAC and overweight/obesity measures...
April 26, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28374919/all-trans-retinoic-acid-ameliorates-arsenic-induced-oxidative-stress-and-apoptosis-in-the-rat-uterus-by-modulating-mapk-signaling-proteins
#8
Aniruddha Chatterjee, Urmi Chatterji
Exposure to arsenic leads to inhibition of the antioxidant defense mechanism of the body. Reactive oxygen species generated in response to arsenic causes reproductive failures in exposed females and also acts as an inducer of apoptosis. As a prospective remedial agent, all-trans retinoic acid (ATRA) was assessed for reversing arsenic-induced oxidative stress and apoptosis. Rats exposed to arsenic for 28 days were allowed to recover naturally or were treated simultaneously with ATRA for 28 days or up to 56 days...
April 4, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28238121/leukocyte-inos-is-required-for-inflammation-and-pathological-remodeling-in-ischemic-heart-failure
#9
Justin R Kingery, Tariq Hamid, Robert K Lewis, Mohamed Ameen Ismahil, Shyam S Bansal, Gregg Rokosh, Tim M Townes, Suzanne T Ildstad, Steven P Jones, Sumanth D Prabhu
In the failing heart, iNOS is expressed by both macrophages and cardiomyocytes. We hypothesized that inflammatory cell-localized iNOS exacerbates left ventricular (LV) remodeling. Wild-type (WT) C57BL/6 mice underwent total body irradiation and reconstitution with bone marrow from iNOS(-/-) mice (iNOS(-/-)c) or WT mice (WTc). Chimeric mice underwent coronary ligation to induce large infarction and ischemic heart failure (HF), or sham surgery. After 28 days, as compared with WTc sham mice, WTc HF mice exhibited significant (p < 0...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28236190/protective-role-of-tetrahydrocurcumin-an-active-polyphenolic-curcuminoid-on-cadmium-inducedoxidative-damage-in-rats
#10
Ramalingam Ramakrishnan, Perumal Elangovan, Leelavinothan Pari
In the present work, protective effect of tetrahydrocurcumin (THC) against oxidative damages in cadmium (Cd)-induced toxicity in rats was evaluated. Cd is an important environmental and industrial toxicant that affects almost all the organs, especially liver. Liver is the major organ responsible for the metabolism and the primary target for many toxic chemicals and drugs. Effect of THC, the curcumin-derived polyphenolic compound on Cd-induced oxidative stress and hepatic damage was evaluated using male albino Wistar rats...
February 24, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28190469/proanthocyanidins-from-vitis-vinifera-inhibit-oxidative-stress-induced-vascular-impairment-in-pulmonary-arteries-from-diabetic-rats
#11
Christian Pinna, Paolo Morazzoni, Angelo Sala
BACKGROUND: Vitis vinifera L. (grape seed extract) is a natural source of proanthocyanidins with antioxidant and free radical-scavenging activities. HYPOTHESIS: Grape seed extract supplementation may prevent vascular endothelium impairment associated with diabetes mellitus in rat pulmonary artery. STUDY DESIGN: We evaluated endothelial function of rat pulmonary artery ex-vivo at the intermediate stage (4 weeks) of streptozotocin (STZ)-induced diabetes mellitus...
February 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28149008/transforming-growth-factor-%C3%AE-1-smad3-signaling-and-redox-status-in-experimentally-induced-nephrotoxicity-impact-of-carnosine
#12
Walaa Arafa Keshk, Mohamed Alaa Katary
Exposure to various organic compounds including drugs and environmental toxins causes cellular damage through generation of free radicals. Carnosine a dipeptide was used in this study to evaluate its effect against CCl4-induced nephrotoxicity. Sixty male albino rats were involved in this study and were equally divided into four groups. CCl4 (3 ml/kg body weight; biweekly for 4 weeks) was given to group II and III. Carnosine (10 mg/kg body weight; once daily for 4 weeks) was given to group III and VI. Transforming growth factor-β1 (TGF-β1) level by immunoassay and Smad3 mRNA level by real-time PCR were estimated in addition to cytochrome P450 2E1 (CYP2E1) activity, renal functions, redox status assessment and histopathological examination of the kidney...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28111973/efficacy-of-crocin-and-safranal-as-protective-agents-against-genotoxic-stress-induced-by-gamma-radiation-urethane-and-procarbazine-in-mice
#13
A Koul, S K Abraham
Crocin (CRO) and safranal (SAF) are bioactive constituents of saffron (dried stigma of Crocus sativus flower), an expensive spice with medicinal properties. Aqueous extract of saffron is known for its antigenotoxic effect against environmental genotoxins/carcinogens. However, there is need to identify saffron constituents responsible for this antigenotoxic effect. The aim of our investigation was to ascertain the role of CRO and SAF as inhibitors of in vivo genotoxic stress. For this purpose, Swiss albino mice were pretreated with CRO (50-mg/kg body weight (bw))/SAF (0...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28002829/reduced-serum-levels-of-zinc-and-superoxide-dismutase-in-obese-individuals
#14
Khadijeh Torkanlou, Bahram Bibak, Alireza Abbaspour, Hamid Abdi, Masoud Saleh Moghaddam, Maryam Tayefi, Elham Mohammadzadeh, Hamideh Safarian Bana, Maliheh Aghasizade, Gordon A Ferns, Amir Avan, Majid Ghayour Mobarhan
The oxidant-stress (OS) has an essential role to play in the pathogenesis and progression of many diseases. OS is the outcome when the level of free-radical-formation is increased or protective-antioxidant-mechanisms are compromised. Its value is expected to increase, although its emerging roles have not been conclusive in different studies. The objective of this study was to explore the level of zinc, copper, and antioxidant in response to obesity-related-stress by measuring superoxide-dismutase (SOD) levels as a key antioxidant-enzyme in 706 individuals with/without obesity...
2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27965752/ascorbate-peroxidase-activity-of-aranda-broga-blue-orchid-protocorm-like-bodies-plbs-in-response-to-pvs2-cryopreservation-method
#15
Khor Soo Ping, Rahmad Zakaria, Sreeramanan Subramaniam
Throughout the cryopreservation process, plants were exposed to a series of abiotic stresses such as desiccation and osmotic pressure due to highly concentrated vitrification solution. Abiotic stress stimulates the production of reactive oxygen species (ROS) which include hydrogen peroxide, superoxide radicals, and singlet oxygen. Higher production of ROS may lead to oxidative stress which contributes to the major injuries in cryopreserved explants. Antioxidant enzymes in plant such as ascorbate peroxidase (APX) can protect plants from cell damage by scavenging the free radicals...
November 2016: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/27927194/melastoma-malabathricum-linn-attenuates-complete-freund-s-adjuvant-induced-chronic-inflammation-in-wistar-rats-via-inflammation-response
#16
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Dinesh Kumar Patel, Nikunj Sethi, Atul Kumar, Nikhil Kumar Sachan, Gaurav Kaithwas, F A Al-Abbasi, Firoz Anwar, Amita Verma
BACKGROUND: Natural products use for arthritis treatment is gaining importance in the medical worldt. Various studies reports medical importance of Melastoma malabathricum Linn. (MM) (Melastomataceae), also known as "putki," has a broad range of health benefits, for its free radical scavenging constituents. The current investigation scrutinizes the antioxidant and anti-inflammatory effect of MM against adjuvant-induced arthritis in experimental rats. METHODS: High-performance thin layer chromatography (HPTLC) was used for estimation of phytochemical-constituents present in the MM extract...
December 7, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27810732/tailored-poly-ethylene-glycol-dimethacrylate-based-shape-memory-polymer-for-orthopedic-applications
#17
G Jerald Maria Antony, Chethan S Jarali, S T Aruna, S Raja
Shape-memory polymers (SMPs) are stimuli-responsive materials known for their outstanding ability to be actuated from temporary shape into original shape. Because of this unique functionality SMPs are promising materials for diverse technological applications including smart biomedical devices. In this article, the work has been focused towards tailoring the SMP precursor and crosslinker wt% to obtain biocompatible acrylate based shape memory polymer with glass transition temperature (Tg) close to human body temperature...
January 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27781114/coenzyme-q10-ameliorates-trimethyltin-chloride-neurotoxicity-in-experimental-model-of-injury-in-dentate-gyrus-of-hippocampus-a-histopathological-and-behavioral-study
#18
Mohammad Hassan Sakhaie, Mansoureh Soleimani, Vahid Pirhajati, Sara Soleimani Asl, Zahra Madjd, Mehdi Mehdizadeh
BACKGROUND: Coenzyme Q10 has antioxidative and free radical scavenging effects. CoQ10 supplementation is known to have neuroprotective effects in some neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. OBJECTIVES: The aim of this study was to evaluate both histopathologic and behavioral whether Coenzyme Q10 is protective against trimethyltin chloride (TMT) induced hippocampal damage. MATERIALS AND METHODS: This was an experimental study...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27777382/prenatal-hyperbaric-normoxia-treatment-improves-healthspan-and-regulates-chitin-metabolic-genes-in-drosophila-melanogaster
#19
Suyeun Yu, Eunil Lee, Bodokhsuren Tsogbadrakh, Gwang-Ic Son, Mari Kim
Aging is a universal, irreversible process accompanied by physiological declines that culminate in death. Rapid progress in gerontology research has revealed that aging can be slowed through mild stress-induced hormesis. We previously reported that hyperbaric normoxia (HN, 2 atm absolute pressure with 10% O2) induces a cytoprotective response in vitro by regulating fibronectin. In the present study, we investigated the hormetic effects of prenatal HN exposure on Drosophila healthspan related to molecular defense mechanisms...
October 24, 2016: Aging
https://www.readbyqxmd.com/read/27759160/snapshot-implications-for-melatonin-in-endoplasmic-reticulum-homeostasis
#20
REVIEW
Wei Hu, Zhiqiang Ma, Shouyin Di, Shuai Jiang, Yue Li, Chongxi Fan, Yang Yang, Dongjin Wang
The endoplasmic reticulum (ER) is an important intracellular membranous organelle. Previous studies have demonstrated that the ER is responsible for protein folding and trafficking, lipid synthesis and the maintenance of calcium homeostasis. Interestingly, the morphology and structure of the ER were recently found to be important. Melatonin is a hormone that anticipates the daily onset of darkness in mammals, and it is well known that melatonin acts as an antioxidant by scavenging free radicals and increasing the activity of antioxidant enzymes in the body...
December 2016: British Journal of Pharmacology
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