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https://www.readbyqxmd.com/read/28727999/drug-ion-co-delivery-multi-functional-nanocarrier-to-regenerate-infected-tissue-defect
#1
Jung-Hwan Lee, Ahmed El-Fiqi, Nandin Mandakhbayar, Hae-Hyoung Lee, Hae-Won Kim
Regeneration of infected tissues is a globally challenging issue in medicine and dentistry. Common clinical therapies involving a complete removal of infected areas together with a treatment of antimicrobial drugs are often suboptimal. Biomaterials with anti-bacterial and pro-regenerative potential can offer a solution to this. Here we design a novel nanocarrier based on a mesoporous silicate-calcium glass by doping with Ag ions and simultaneously loading antimicrobial drugs onto mesopores. The nanocarriers could controllably release multiple ions (silver, calcium, and silicate) and drugs (tetracycline or chlorohexidine) to levels therapeutically relevant, and effectively internalize to human dental stem cells (∼90%) with excellent viability, ultimately stimulating odontogenic differentiation...
July 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28727472/relieving-dry-mouth-varying-levels-of-ph-found-in-bottled-water
#2
Bailey Jean Fisher, Angela Spencer, Van Haywood, Gayathri Konchady
It is estimated that 30% of people older than 60 years suffer from hyposalivation or dry mouth. Drinking water frequently has been recommended as a safe, non-pharmacologic way to combat hyposalivation. The saliva in patients with dry mouth is acidic. Beverages consumed daily may have an erosive potential on teeth. The pH and the mineral content of the beverage determine its erosive potential. An acidic beverage, therefore, may have harmful effects on mineralized tooth structures, causing erosion of enamel, dentin, and cementum...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28727410/exosomes-mediate-epithelium-mesenchyme-crosstalk-in-organ-development
#3
Nan Jiang, Lusai Xiang, Ling He, Guodong Yang, Jinxuan Zheng, Chenglin Wang, Yimei Zhang, Sainan Wang, Yue Zhou, Tzong-Jen Sheu, Jiaqian Wu, Kenian Chen, Paulo G Coelho, Nicky M Tovar, Shin Hye Kim, Mo Chen, Yan-Heng Zhou, Jeremy J Mao
Organ development requires complex signaling by cells in different tissues. Epithelium and mesenchyme interactions are crucial for the development of the skin, hair follicles, kidney, lungs, prostate, major glands and the teeth. Despite myriad literature on cell-cell interactions and ligand-receptor binding, the roles extracellular vesicles in epithelium-mesenchyme interactions during organogenesis are poorly understood. Here, we discovered that ~100 nm exosomes were secreted by the epithelium and mesenchyme of a developing tooth organ, and diffused through the basement membrane...
July 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28722000/comparative-evaluation-of-shear-bond-strength-of-zirconia-restorations-cleansed-various-cleansing-protocols-bonded-with-two-different-resin-cements-an-in-vitro-study
#4
Sriram Sankar, Vijay Venkatesh Kondas, Sihi Vahanan Dhanasekaran, Prem Kumar Elavarasu
CONTEXT: Yttria partially stabilized tetragonal zirconia polycrystalline restorations have gained widespread use because of its enhanced strength and esthetics. During the try-in process, zirconia is likely to be contaminated with saliva. This contamination leads to a clear weakening of the bond between restorative material and cement. For this reason, zirconia surface should be cleaned before cementation. Hence, the purpose of this study is to compare the shear bond strength of zirconia restorations cleansed with various surface cleansing protocols bonded with two different resin cements...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28721317/ameloblastic-fibrodentinoma-a-case-with-varied-patterns-of-dysplastic-dentin
#5
Radhika M Bavle, Sudhakara Muniswammappa, Reshma Venugopal, Amulya S R
Ameloblastic fibrodentinoma is a benign odontogenic tumor belonging to the category of "odontogenic epithelium with odontogenic ectomesenchyme" along with recognition of induction in the form of dentin in atypical or dysplastic forms. The biological behaviour of ameloblastic fibrodentinoma is not very different from ameloblastic fibroma; hence, it is treated similarly by conservative procedures. It is important to understand the histopathogenesis of these rare tumors. Though rare, they are an independent entity awaiting recognition...
June 14, 2017: Curēus
https://www.readbyqxmd.com/read/28720286/stress-generation-during-pecking-motion-of-rotary-nickel-titanium-instruments-with-different-pecking-depth
#6
Jung-Hong Ha, Sang Won Kwak, Asgeir Sigurdsson, Seok Woo Chang, Sung Kyo Kim, Hyeon-Cheol Kim
INTRODUCTION: The aim of this study was to evaluate the effect of different pecking depth on the stress generated by the screw-in forces of a rotating endodontic file in simulated canals. METHODS: Twenty simulated resin blocks with a J-shaped curvature were used. Twenty OneG files (MicroMega, Besançon, France) were assigned for a screw-in test depending on the pecking depth in 2 groups (n = 10). The files were operated at 300 rpm, and the up and down speed was controlled at 1 mm/s stroke velocity and a 10-millisecond dwell time using a customized device...
July 15, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28718921/homology-homoplasy-and-cusp-variability-at-the-enamel-dentine-junction-of-hominoid-molars
#7
Alejandra Ortiz, Shara E Bailey, Jean-Jacques Hublin, Matthew M Skinner
Evolutionary studies of mammalian teeth have generally concentrated on the adaptive and functional significance of dental features, whereas the role of development on phenotypic generation and as a source of variation has received comparatively little attention. The present study combines an evolutionary biological framework with state-of-the-art imaging techniques to examine the developmental basis of variation of accessory cusps. Scholars have long used the position and relatedness of cusps to other crown structures as a criterion for differentiating between developmentally homologous and homoplastic features, which can be evaluated with greater accuracy at the enamel-dentine junction (EDJ)...
July 18, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28717800/from-molecules-to-macrostructures-recent-development-of-bioinspired-hard-tissue-repair
#8
REVIEW
Chunmei Ding, Zhuoxin Chen, Jianshu Li
Enamel, dentin and bone are calcified hard tissues in the human body that play significant roles in food mastication and movement support. Generally, hard tissues lack the ability of self-repair, except for the regeneration ability of bone for small-scale defects. Fabrication of man-made repair materials is therefore highly demanded. In this review, following a bioinspired strategy, we describe the composition and multiscale structures of different hard tissues, and highlight the key points for the reconstruction of hard tissues...
July 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28717792/accelerated-fatigue-resistance-%C3%A2-of-novel-design-histoanatomic-%C3%A2-implant-restorations-made-of-%C3%A2-cad-cam-bilaminar-assemblies
#9
Ivan Molina, Jack Goldberg, Claudia Maziero Volpato, Pascal Magne
OBJECTIVES: Evaluate the fatigue resistance and failure mode of novel-design implant restorations made of histoanatomic computer-assisted design/computer-assisted manufacturing (CAD/CAM) bilaminar bonded assemblies. MATERIAL AND METHODS: 60 screw-retained implant restorations were fabricated. Monolithic restorations were used as a control group (15 lithium disilicate: group CE; and 15 nanofilled composite resin: group CL), and compared with bilaminar restorations (15 dentin-shaped lithium disilicate mesostructures with a bonded nanofilled composite resin veneer: group CEL; and 15 dentin-shaped nanofilled composite resin mesostructures with a bonded lithium disilicate veneer: group CLE)...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28717633/cementum-and-dentin-repair-following-root-damage-caused-by-the-insertion-of-self-tapping-and-self-drilling-miniscrews
#10
Majid Ghanbarzadeh, Farzin Heravi, Reihaneh Abrishamchi, Hooman Shafaee, Narges Ghazi, Parya Heravi, Hamid Ghanbarzadeh
OBJECTIVE: The aim of this study was to evaluate the histological responses of cementum, root dentin, and pulp following intentional root injuries caused via self-tapping and self-drilling miniscrews. MATERIALS AND METHODS: Fourteen patients (with a mean age of 15.7 years and age range of 14-18 years) who were scheduled for the extraction of all four first premolars as part of their orthodontic treatment plan participated in this study. The roots of the right and the left quadrants' first premolars were designedly injured using self-tapping miniscrews and self-drilling miniscrews, respectively...
July 2017: Journal of Orthodontic Science
https://www.readbyqxmd.com/read/28716215/clinical-and-radiographic-assessment-of-the-efficacy-of-a-collagen-membrane-in-regenerative-endodontics-a-randomized-controlled-clinical%C3%A2-trial
#11
Xijun Jiang, He Liu, Chufang Peng
INTRODUCTION: Recent reviews confirm a general lack of randomized, controlled clinical studies on the efficacy of regenerative endodontics in immature teeth affected by pulp and periapical diseases. Moreover, we have no evidence of the curative efficacy of collagen membranes used as scaffolds in regenerative endodontics. Here, we evaluated whether a Bio-Gide collagen membrane (Geistlich Pharma AG, Wolhusen, Switzerland) has efficacy in promoting dentin formation in regenerative endodontics...
July 14, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28714191/disordered-conformation-with-low-pii-helix-in-phosphoproteins-orchestrates-biomimetic-apatite-formation
#12
Melika Sarem, Steffen Lüdeke, Ralf Thomann, Pavel Salavei, Zhaoyong Zou, Wouter Habraken, Admir Masic, V Prasad Shastri
The interplay between noncollagenous proteins and biomineralization is widely accepted, yet the contribution of their secondary structure in mineral formation remains to be clarified. This study demonstrates a role for phosvitin, an intrinsically disordered phosphoprotein, in chick embryo skeletal development, and using circular dichroism and matrix least-squares Henderson-Hasselbalch global fitting, unravels three distinct pH-dependent secondary structures in phosvitin. By sequestering phosvitin on a biomimetic 3D insoluble cationic framework at defined pHs, access is gained to phosvitin in various conformational states...
July 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28713769/fracture-fragment-reattachment-using-projectors-and-anatomic-everstick-post%C3%A2-an-ultraconservative-approach
#13
Velagala L Deepa, Satti Narayana Reddy, Venkata Charan Garapati, Srirama Rao Sudhamashetty, Padmasri Yadla
Traumatized anterior teeth require quick functional and esthetic repair. Tooth fragment reattachment is a simple and conservative clinical procedure to restore fractured anterior teeth. Different techniques of reattachment include enamel beveling, "v-" shaped internal enamel and dentin grooves, external chamfer, over contouring, and by placing fiber post, all of which were invasive methods. This article describes a novel technique of reattachment using canal projectors for stabilizing fractured fragments followed by endodontic therapy and internal reinforcement with custom fiber post (everStick Post™, GC Corporation, Tokyo, Japan)...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28713512/laboratory-evaluation-of-the-effect-of-unfilled-resin-after-the-use-of-self-etch-and-total-etch-dentin-adhesives-on-the-shear-bond-strength-of-composite-to-dentin
#14
Ehsan Baradaran Nasseri, Sara Majidinia, Davood Aghasizadeh Sharbaf
BACKGROUND: Based on the frequent application of composite resins as tooth-colored fillings, this method is considered a viable alternative to dental amalgam. However, this method has the low bond strength of the composite to dentin. To solve this issue, various dental adhesive systems with different characteristics have been developed by dentistry experts. AIM: To assess the effect of an additional layer of unfilled resin in self-etch and total-etch dentin adhesives on the shear bond strength (SBS) of composite to dentin...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28713017/intracellular-co-delivery-of-sr-ion-and-phenamil-drug-through-mesoporous-bioglass-nanocarriers-synergizes-bmp-signaling-and-tissue-mineralization
#15
Jung-Hwan Lee, Nandin Mandakhbayar, Ahmed El-Fiqi, Haw-Won Kim
Inducing differentiation and maturation of resident multipotent stem cells (MSCs) is an important strategy to regenerate hard tissues in mal-calcification conditions. Here we explore a co-delivery approach of therapeutic molecules comprised of ion and drug through a mesoporous bioglass nanoparticle (MBN) for this purpose. Recently, MBN has offered unique potential as a nanocarrier for hard tissues, in terms of high mesoporosity, bone bioactivity (and possibly degradability), tunable delivery of biomolecules, and ionic modification...
July 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28712739/biocompatibility-and-bond-degradation-of-poly-acrylic-acid-coated-copper-iodide-adhesives
#16
Adi ALGhanem, Gabriela Fernandes, Michelle Visser, Rosemary Dziak, Walter G Renné, Camila Sabatini
OBJECTIVE: To investigate the effect of poly-acrylic acid (PAA) copper iodide (CuI) adhesives on bond degradation, tensile strength, and biocompatibility. METHODS: PAA-CuI particles were incorporated into Optibond XTR, Optibond Solo and XP Bond in 0.1 and 0.5mg/ml. Clearfil SE Protect, an MDPB-containing adhesive, was used as control. The adhesives were applied to human dentin, polymerized and restored with composite in 2mm-increments. Resin-dentin beams (0.9±0...
July 13, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28712639/reduction-in-fracture-resistance-of-the-root-with%C3%A2-aging
#17
Weishi Yan, Carolina Montoya, Marit Øilo, Alex Ossa, Avina Paranjpe, Hai Zhang, Dwayne Arola
INTRODUCTION: The incidence of vertical root fracture in endodontically treated teeth increases with patient age. This study evaluated the microstructure, chemical composition, and mechanical properties of radicular dentin as a function of aging. METHODS: Single-rooted teeth were obtained from adult donors ranging from age 15 to older than 80 years. Beams were extracted from the middle third of the root and subjected to 4-point flexure to failure to evaluate strength of dentin in terms of donor age...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28712638/canal-transportation-unprepared-areas-and-dentin-removal-after-preparation-with-bt-race-and-protaper-next-systems
#18
Sabrina C Brasil, Marília F Marceliano-Alves, Márcia L Marques, João P Grillo, Mariane F L S Lacerda, Flávio R F Alves, José F Siqueira, José C Provenzano
INTRODUCTION: This study compared the shaping ability of ProTaper Next (Dentsply Sirona, Tulsa, OK) and BT-RaCe (FKG Dentaire, La Chaux-de-Fonds, Switzerland) instrument systems in the mesial canals of mandibular molars using micro-computed tomographic (micro-CT) imaging. METHODS: A total of 17 type IV mesial roots of extracted first mandibular molars were scanned using micro-CT imaging before and after root canal preparation with the 2 instrument systems. Both systems were used in the same root but alternating the mesial canals from root to root...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28709835/the-antimicrobial-peptide-human-%C3%AE-defensin-1-potentiates-in-vitro-osteoclastogenesis-via-activation-of-the-p44-42-mitogen-activated-protein-kinases
#19
Anupong Makeudom, Chayarop Supanchart, Pattanin Montreekachon, Sakornrat Khongkhunthian, Thanapat Sastraruji, Julaporn Krisanaprakornkit, Suttichai Krisanaprakornkit
Previous studies have demonstrated increased expression and raised levels of human β-defensin (hBD)-1 in gingival tissue and crevicular fluid of patients with chronic periodontitis and peri-implantitis, oral bone-resorbing diseases caused by enhanced osteoclastogenesis. Therefore, we aimed to investigate the effect of hBD-1 on osteoclast formation and function and to elucidate the involved signaling pathway in vitro. Human peripheral blood mononuclear cells (PBMCs) were first incubated with various doses of hBD-1 and cell viability was assayed by MTT...
July 11, 2017: Peptides
https://www.readbyqxmd.com/read/28708217/evaluation-of-calcium-ca2-and-hydroxide-oh-ion-diffusion-rates-of-indirect-pulp-capping-materials
#20
Merve Kurun Aksoy, Firdevs Tulga Oz, Kaan Orhan
INTRODUCTION: The aim of this study was to evaluate and compare the calcium (Ca2+) and hydroxide (OH-) ion release of 4 artificially produced pulp capping materials (MTA, Biodentin, TheraCal LC, Calsimol) used for indirect pulp capping treatment. METHODS: In total, 70 freshly extracted human third molar teeth were used for the study. Cavities of extracted teeth were prepared by round burs. The remaining dentin thickness (1 ± 0.3 mm) tissue was measured by a micrometer and cone beam computerized tomography...
July 8, 2017: International Journal of Artificial Organs
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