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Tommy John

Christine C Johnson, Grant H Garcia, Joseph N Liu, Jeffrey G Stepan, Ronak M Patel, Joshua S Dines
BACKGROUND: The quality of medical information on the Internet has come under scrutiny. This study investigates the quality, accuracy, and readability of online information regarding ulnar collateral ligament (UCL) injuries. METHODS: Three search terms ("elbow ulnar collateral ligament injury," "tommy john injury," and "pitcher's elbow") were entered into 3 Internet search engines. Three independent reviewers evaluated the content and accuracy of the information with a set of predetermined scoring criteria...
October 10, 2016: Journal of Shoulder and Elbow Surgery
Rosa María Agra, Nasser M Al-Daghri, Lina Badimon, Vicente Bodi, Federico Carbone, Mao Chen, Judit Cubedo, Robin P F Dullaart, Sonia Eiras, Carmelo García-Monzón, Thomas Gary, Antonio Gnoni, Águeda González-Rodríguez, Thomas Gremmel, Franz Hafner, Tommi Hakala, Baotao Huang, Kelly Ickmans, Concetta Irace, Ivana Kholová, Nina Kimer, Ville Kytö, Winfried März, Tomasz Miazgowski, Søren Møller, Fabrizio Montecucco, Giampaolo Niccoli, Jo Nijs, Serkan Ozben, Tomris Ozben, Ioannis Papassotiriou, Maria Papastamataki, Marta Reina-Couto, Cesar Rios-Navarro, Andreas Ritsch, Shaun Sabico, Ian W Seetho, Anna Severino, Jussi Sipilä, Teresa Sousa, Aleksandra Taszarek, Federica Taurino, Uwe J F Tietge, Cesare Tripolino, Willemien Verloop, Michiel Voskuil, John P H Wilding
No abstract text is available yet for this article.
October 2016: European Journal of Clinical Investigation
John R Bergquist, Ryan T Groeschl, Tommy Ivanics, Christopher R Shubert, Elizabeth B Habermann, Michael L Kendrick, Michael B Farnell, David M Nagorney, Mark J Truty, Rory L Smoot
BACKGROUND: Intrahepatic lesions of mixed hepatocellular (HCC) and intrahepatic cholangiocellular carcinoma (ICC) histology are rare. The aim was to describe the natural history of these tumors relative to monomorphic ICC or HCC utilizing the National Cancer Data Base (NCDB). METHODS: Patients with ICC, HCC, and mixed histology (cHCC-CCA) were identified in the NCDB (2004-2012). Inter-group comparisons were made. Kaplan-Meier and multivariable Cox Proportional Hazards analyzed overall survival...
August 18, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Rachel Patrick, Josh McGinty, Ann Lucado, Beth Collier
BACKGROUND: Ulnar collateral ligament (UCL) tears and associated Tommy Johns surgical intervention from excessive and poor quality pitching has increased immensely-with more college and professional pitchers undergoing the surgery in 2014 alone than in the 1990s as a whole.(1) Faulty mechanics developed at young ages are often well-engrained by the late adolescent years and the minimal healing ability of the largely avascular UCL often leads to delayed safe return to sport.(2). PURPOSE: The purpose of this case study was to describe an innovative, multimodal approach to conservative management of a chronic UCL injury in a college-aged baseball pitcher...
August 2016: International Journal of Sports Physical Therapy
Robert S Kirsner, Wolfgang Vanscheidt, David H Keast, John C Lantis, Cyaandi R Dove, Shawn M Cazzell, Mher Vartivarian, Matthias Augustin, William A Marston, Nicholas D McCoy, D Innes Cargill, Tommy D Lee, Jaime E Dickerson, Herbert B Slade
In 2012 we reported promising results from a Phase 2 clinical trial of HP802-247, a novel spray-applied investigational treatment for chronic venous leg ulcers (VLU) consisting of human, allogeneic fibroblasts and keratinocytes. We now describe Phase 3 clinical testing of HP802-247, its failure to detect efficacy, and subsequent investigation into the root causes of the failure. Two randomized, controlled trials enrolled a total of 673 adult outpatients at 96 centers in North America and Europe. The primary endpoint was the proportion of ulcers with confirmed closure at the end of 12 weeks of treatment...
August 6, 2016: Wound Repair and Regeneration
Ulrike Kusebauch, David S Campbell, Eric W Deutsch, Caroline S Chu, Douglas A Spicer, Mi-Youn Brusniak, Joseph Slagel, Zhi Sun, Jeffrey Stevens, Barbara Grimes, David Shteynberg, Michael R Hoopmann, Peter Blattmann, Alexander V Ratushny, Oliver Rinner, Paola Picotti, Christine Carapito, Chung-Ying Huang, Meghan Kapousouz, Henry Lam, Tommy Tran, Emek Demir, John D Aitchison, Chris Sander, Leroy Hood, Ruedi Aebersold, Robert L Moritz
The ability to reliably and reproducibly measure any protein of the human proteome in any tissue or cell type would be transformative for understanding systems-level properties as well as specific pathways in physiology and disease. Here, we describe the generation and verification of a compendium of highly specific assays that enable quantification of 99.7% of the 20,277 annotated human proteins by the widely accessible, sensitive, and robust targeted mass spectrometric method selected reaction monitoring, SRM...
July 28, 2016: Cell
John R Bergquist, Tommy Ivanics, Curtis B Storlie, Ryan T Groeschl, May C Tee, Elizabeth B Habermann, Rory L Smoot, Michael L Kendrick, Michael B Farnell, Lewis R Roberts, Gregory J Gores, David M Nagorney, Mark J Truty
BACKGROUND: Optimal management of patients with intrahepatic cholangiocarcinoma (ICCA) and elevated CA19-9 remains undefined. We hypothesized CA19-9 elevation above normal indicates aggressive biology and that inclusion of CA19-9 would improve staging discrimination. METHODS: The National Cancer Data Base (NCDB-2010-2012) was reviewed for patients with ICCA and reported CA19-9. Patients were stratified by CA19-9 above/below normal reference range. Unadjusted Kaplan-Meier and adjusted Cox-proportional-hazards analysis of overall survival (OS) were performed...
September 2016: Journal of Surgical Oncology
Tommy S de Windt, Juliette C Sorel, Lucienne A Vonk, Michelle M A Kip, Maarten J Ijzerman, Daniel B F Saris
Both the complexity of clinically applied tissue engineering techniques for articular cartilage repair - such as autologous chondrocyte implantation (ACI) - plus increasing healthcare costs, and market competition, are forcing a shift in focus from two-stage to single-stage interventions that are more cost-effective. Early health economic models are expected to provide essential insight in the parameters driving the cost-effectiveness of new interventions before they are introduced into clinical practice. The present study estimated the likely incremental cost-effectiveness ratio (ICER) of a new investigator-driven single-stage procedure (IMPACT) compared with both microfracture and ACI, and identified those parameters that affect the cost-effectiveness...
July 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
William Shotyk, Beatriz Bicalho, Chad W Cuss, M John M Duke, Tommy Noernberg, Rick Pelletier, Eiliv Steinnes, Claudio Zaccone
Sphagnum fuscum was collected from twenty-five ombrotrophic (rain-fed) peat bogs surrounding open pit mines and upgrading facilities of Athabasca Bituminous Sands (ABS) in northern Alberta (AB) in order to assess the extent of atmospheric contamination by trace elements. As a control, this moss species was also collected at a bog near Utikuma (UTK) in an undeveloped part of AB and 264km SW of the ABS region. For comparison, this moss was also collected in central AB, in the vicinity of the City of Edmonton which is approximately 500km to the south of the ABS region, from the Wagner Wetland which is 22km W of the City, from Seba Beach (ca...
July 2016: Environment International
Clemens W Janssen, Christopher A Lowry, Matthias R Mehl, John J B Allen, Kimberly L Kelly, Danielle E Gartner, Angelica Medrano, Tommy K Begay, Kelly Rentscher, Joshua J White, Andrew Fridman, Levi J Roberts, Megan L Robbins, Kay-U Hanusch, Steven P Cole, Charles L Raison
IMPORTANCE: Limitations of current antidepressants highlight the need to identify novel treatments for major depressive disorder. A prior open trial found that a single session of whole-body hyperthermia (WBH) reduced depressive symptoms; however, the lack of a placebo control raises the possibility that the observed antidepressant effects resulted not from hyperthermia per se, but from nonspecific aspects of the intervention. OBJECTIVE: To test whether WBH has specific antidepressant effects when compared with a sham condition and to evaluate the persistence of the antidepressant effects of a single treatment...
August 1, 2016: JAMA Psychiatry
Tommy Ivanics, John R Bergquist, Christopher R Shubert, Rory L Smoot, Elizabeth B Habermann, Mark J Truty
OBJECTIVES: Primary pancreatic small cell carcinomas (PSCCs) are rare, and benefits of surgery are unknown. Utilizing the National Cancer Data Base, surgical outcomes of PSCC were determined and compared with pancreatic ductal adenocarcinoma (PDAC). METHODS: Patients with histologically confirmed PSCC (n = 541) and PDAC (n = 156,733) were identified from the National Cancer Data Base (1998-2011). Parametric comparisons of patient and outcomes data were made. Unadjusted Kaplan-Meier and Cox proportional hazards analyses were performed...
May 11, 2016: Pancreas
Tommy Dickinson, John Hopton, Mark Pilling
No abstract text is available yet for this article.
May 2016: Journal of Clinical Nursing
Yingchang Lu, Felix R Day, Stefan Gustafsson, Martin L Buchkovich, Jianbo Na, Veronique Bataille, Diana L Cousminer, Zari Dastani, Alexander W Drong, Tõnu Esko, David M Evans, Mario Falchi, Mary F Feitosa, Teresa Ferreira, Åsa K Hedman, Robin Haring, Pirro G Hysi, Mark M Iles, Anne E Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R B Perry, Tune H Pers, Qibin Qi, Marianna Sanna, Ellen M Schmidt, William R Scott, Dmitry Shungin, Alexander Teumer, Anna A E Vinkhuyzen, Ryan W Walker, Harm-Jan Westra, Mingfeng Zhang, Weihua Zhang, Jing Hua Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer Singh Ahluwalia, Stephan J L Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S Buchman, Tommy Cederholm, Audrey C Choh, Hyung Jin Choi, Joanne E Curran, Lisette C P G M de Groot, Philip L De Jager, Rosalie A M Dhonukshe-Rutten, Anke W Enneman, Elodie Eury, Daniel S Evans, Tom Forsen, Nele Friedrich, Frédéric Fumeron, Melissa E Garcia, Simone Gärtner, Bok-Ghee Han, Aki S Havulinna, Caroline Hayward, Dena Hernandez, Hans Hillege, Till Ittermann, Jack W Kent, Ivana Kolcic, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G Lee, Jong-Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo-Pekka Lyytikäinen, Carolina Medina-Gomez, Karl Michaëlsson, Mike A Nalls, Carrie M Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A Sarzynski, Chan Soo Shin, Nina Smolej Narančić, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen-Thiessen, Yun Ju Sung, Karin M A Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie van der Velde, Natasja M van Schoor, Niek Verweij, Alan F Wright, Lei Yu, Joseph M Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne U Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian'an Luan, Anubha Mahajan, Satu Männistö, Cameron D Palmer, Janina S Ried, Robert A Scott, Alena Stancáková, Peter J Wagner, Ayse Demirkan, Angela Döring, Vilmundur Gudnason, Douglas P Kiel, Brigitte Kühnel, Massimo Mangino, Barbara Mcknight, Cristina Menni, Jeffrey R O'Connell, Ben A Oostra, Alan R Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M van Duijn, Peter Vollenweider, Charles C White, Michael Boehnke, Yvonne Boettcher, Richard S Cooper, Nita G Forouhi, Christian Gieger, Harald Grallert, Aroon Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika Kivimaki, Meena Kumari, Markku Laakso, Claudia Langenberg, Allan Linneberg, Amy Luke, Colin A Mckenzie, Aarno Palotie, Oluf Pedersen, Annette Peters, Konstantin Strauch, Bamidele O Tayo, Nicholas J Wareham, David A Bennett, Lars Bertram, John Blangero, Matthias Blüher, Claude Bouchard, Harry Campbell, Nam H Cho, Steven R Cummings, Stefan A Czerwinski, Ilja Demuth, Rahel Eckardt, Johan G Eriksson, Luigi Ferrucci, Oscar H Franco, Philippe Froguel, Ron T Gansevoort, Torben Hansen, Tamara B Harris, Nicholas Hastie, Markku Heliövaara, Albert Hofman, Joanne M Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Paul B Knekt, Seppo Koskinen, Peter Kovacs, Terho Lehtimäki, Lars Lind, Yongmei Liu, Eric S Orwoll, Clive Osmond, Markus Perola, Louis Pérusse, Olli T Raitakari, Tuomo Rankinen, D C Rao, Treva K Rice, Fernando Rivadeneira, Igor Rudan, Veikko Salomaa, Thorkild I A Sørensen, Michael Stumvoll, Anke Tönjes, Bradford Towne, Gregory J Tranah, Angelo Tremblay, André G Uitterlinden, Pim van der Harst, Erkki Vartiainen, Jorma S Viikari, Veronique Vitart, Marie-Claude Vohl, Henry Völzke, Mark Walker, Henri Wallaschofski, Sarah Wild, James F Wilson, Loïc Yengo, D Timothy Bishop, Ingrid B Borecki, John C Chambers, L Adrienne Cupples, Abbas Dehghan, Panos Deloukas, Ghazaleh Fatemifar, Caroline Fox, Terrence S Furey, Lude Franke, Jiali Han, David J Hunter, Juha Karjalainen, Fredrik Karpe, Robert C Kaplan, Jaspal S Kooner, Mark I McCarthy, Joanne M Murabito, Andrew P Morris, Julia A N Bishop, Kari E North, Claes Ohlsson, Ken K Ong, Inga Prokopenko, J Brent Richards, Eric E Schadt, Tim D Spector, Elisabeth Widén, Cristen J Willer, Jian Yang, Erik Ingelsson, Karen L Mohlke, Joel N Hirschhorn, John Andrew Pospisilik, M Carola Zillikens, Cecilia Lindgren, Tuomas Oskari Kilpeläinen, Ruth J F Loos
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass...
2016: Nature Communications
Shuijie Li, Stuart M Fell, Olga Surova, Erik Smedler, Karin Wallis, Zhi Xiong Chen, Ulf Hellman, John Inge Johnsen, Tommy Martinsson, Rajappa S Kenchappa, Per Uhlén, Per Kogner, Susanne Schlisio
KIF1Bβ is a candidate 1p36 tumor suppressor that regulates apoptosis in the developing sympathetic nervous system. We found that KIF1Bβ activates the Ca(2+)-dependent phosphatase calcineurin (CN) by stabilizing the CN-calmodulin complex, relieving enzymatic autoinhibition and enabling CN substrate recognition. CN is the key mediator of cellular responses to Ca(2+) signals and its deregulation is implicated in cancer, cardiac, neurodegenerative, and immune disease. We show that KIF1Bβ affects mitochondrial dynamics through CN-dependent dephosphorylation of Dynamin-related protein 1 (DRP1), causing mitochondrial fission and apoptosis...
January 25, 2016: Developmental Cell
Hmwe H Kyu, Christine Pinho, Joseph A Wagner, Jonathan C Brown, Amelia Bertozzi-Villa, Fiona J Charlson, Luc Edgar Coffeng, Lalit Dandona, Holly E Erskine, Alize J Ferrari, Christina Fitzmaurice, Thomas D Fleming, Mohammad H Forouzanfar, Nicholas Graetz, Caterina Guinovart, Juanita Haagsma, Hideki Higashi, Nicholas J Kassebaum, Heidi J Larson, Stephen S Lim, Ali H Mokdad, Maziar Moradi-Lakeh, Shaun V Odell, Gregory A Roth, Peter T Serina, Jeffrey D Stanaway, Awoke Misganaw, Harvey A Whiteford, Timothy M Wolock, Sarah Wulf Hanson, Foad Abd-Allah, Semaw Ferede Abera, Laith J Abu-Raddad, Fadia S AlBuhairan, Azmeraw T Amare, Carl Abelardo T Antonio, Al Artaman, Suzanne L Barker-Collo, Lope H Barrero, Corina Benjet, Isabela M Bensenor, Zulfiqar A Bhutta, Boris Bikbov, Alexandra Brazinova, Ismael Campos-Nonato, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Rajiv Chowdhury, Cyrus Cooper, John A Crump, Rakhi Dandona, Louisa Degenhardt, Robert P Dellavalle, Samath D Dharmaratne, Emerito Jose A Faraon, Valery L Feigin, Thomas Fürst, Johanna M Geleijnse, Bradford D Gessner, Katherine B Gibney, Atsushi Goto, David Gunnell, Graeme J Hankey, Roderick J Hay, John C Hornberger, H Dean Hosgood, Guoqing Hu, Kathryn H Jacobsen, Sudha P Jayaraman, Panniyammakal Jeemon, Jost B Jonas, André Karch, Daniel Kim, Sungroul Kim, Yoshihiro Kokubo, Barthelemy Kuate Defo, Burcu Kucuk Bicer, G Anil Kumar, Anders Larsson, Janet L Leasher, Ricky Leung, Yongmei Li, Steven E Lipshultz, Alan D Lopez, Paulo A Lotufo, Raimundas Lunevicius, Ronan A Lyons, Marek Majdan, Reza Malekzadeh, Taufiq Mashal, Amanda J Mason-Jones, Yohannes Adama Melaku, Ziad A Memish, Walter Mendoza, Ted R Miller, Charles N Mock, Joseph Murray, Sandra Nolte, In-Hwan Oh, Bolajoko Olubukunola Olusanya, Katrina F Ortblad, Eun-Kee Park, Angel J Paternina Caicedo, Scott B Patten, George C Patton, David M Pereira, Norberto Perico, Frédéric B Piel, Suzanne Polinder, Svetlana Popova, Farshad Pourmalek, D Alex Quistberg, Giuseppe Remuzzi, Alina Rodriguez, David Rojas-Rueda, Dietrich Rothenbacher, David H Rothstein, Juan Sanabria, Itamar S Santos, David C Schwebel, Sadaf G Sepanlou, Amira Shaheen, Rahman Shiri, Ivy Shiue, Vegard Skirbekk, Karen Sliwa, Chandrashekhar T Sreeramareddy, Dan J Stein, Timothy J Steiner, Lars Jacob Stovner, Bryan L Sykes, Karen M Tabb, Abdullah Sulieman Terkawi, Alan J Thomson, Andrew L Thorne-Lyman, Jeffrey Allen Towbin, Kingsley Nnanna Ukwaja, Tommi Vasankari, Narayanaswamy Venketasubramanian, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Elisabete Weiderpass, Robert G Weintraub, Andrea Werdecker, James D Wilkinson, Solomon Meseret Woldeyohannes, Charles D A Wolfe, Yuichiro Yano, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Maysaa El Sayed Zaki, Mohsen Naghavi, Christopher J L Murray, Theo Vos
IMPORTANCE: The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. OBJECTIVE: To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study...
March 2016: JAMA Pediatrics
Joseph N Liu, Grant H Garcia, Stan Conte, Neal ElAttrache, David W Altchek, Joshua S Dines
BACKGROUND: With the recent rise in the number of Tommy John surgeries, a proportionate rise in revisions is expected. However, much is unknown regarding the current revision rate of Tommy John surgery, return to play, and change in performance in Major League Baseball (MLB) pitchers. METHODS: Publicly available databases were used to obtain a list of all MLB pitchers who underwent primary and revision Tommy John surgery. Pitching performance preoperatively and postoperatively for pitchers who returned to 1 or more MLB games after revision surgery was compared with controls matched for age and position...
January 2016: Journal of Shoulder and Elbow Surgery
Ying Zhang, Jieqing Fan, Joshua W K Ho, Tommy Hu, Stephen C Kneeland, Xueping Fan, Qiongchao Xi, Michael A Sellarole, Wilhelmine N de Vries, Weining Lu, Salil A Lachke, Richard A Lang, Simon W M John, Richard L Maas
The developing lens is a powerful system for investigating the molecular basis of inductive tissue interactions and for studying cataract, the leading cause of blindness. The formation of tightly controlled cell-cell adhesions and cell-matrix junctions between lens epithelial (LE) cells, between lens fiber (LF) cells, and between these two cell populations enables the vertebrate lens to adopt a highly ordered structure and acquire optical transparency. Adhesion molecules are thought to maintain this ordered structure, but little is known about their identity or interactions...
January 15, 2016: Development
Tommy Cederholm, John E Morley
PURPOSE OF REVIEW: To highlight recent conundrums in the interface of nutrition, biology and aging. RECENT FINDINGS: A Mediterranean diet with extra virgin olive oil, or similar plant-based diets, including five helpings of fruit and vegetables, exercise and nonsmoking are the mainstays of aging successfully. Recent studies have questioned the utility of weight loss in older persons, the use of antioxidant vitamin supplements as well as the appropriate level of sodium intake...
January 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Jidong Hong, Zhongxing Liao, Yan Zhuang, Lawrence B Levy, Tommy Sheu, John V Heymach, Quynh-Nhu Nguyen, Ting Xu, Ritsuko Komaki, Daniel R Gomez
PURPOSE: We analyzed overall and disease-free survival (OS and DFS) after definitive (chemo)radiation for stage III non-small cell lung cancer with 2 statistical methods: Kaplan-Meier (KM) analysis, with diagnosis as index date, and conditional survival (CS) analysis, with a variety of disease-free index dates, and determined whether prognostic factors varied based on the reference date. MATERIALS AND METHODS: All 651 patients analyzed received definitive (chemo)radiotherapy for stage III non-small cell lung cancer in November 1998 to December 2010 at a single institution; all had Karnofsky performance status scores ≥60 and received ≥60 Gy...
November 3, 2015: American Journal of Clinical Oncology
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