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https://www.readbyqxmd.com/read/29758568/social-media-in-shoulder-elbow-surgery-an-analysis-of-twitter-and-instagram
#1
Prem N Ramkumar, Sergio M Navarro, Margaret M Cornaghie, Heather S Haeberle, Hafsah Hameed, Mark S Schickendantz, Eric T Ricchetti, Joseph P Iannotti
Social media provide a unique method of analyzing outcomes and quality in medicine. The purpose of this observational study was to investigate the nature of social media content related to shoulder and elbow (S&E) surgery posted by patients, surgeons, and hospitals. A public search of Instagram for a two-year period yielded 1,177 patient-related posts. A categorical system assessed the perspective, timing, tone, and content of each post. Twitter accounts of 77 S&E specialists from the top five ranked U...
May 14, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29700964/refractive-regression-after-laser-in-situ-keratomileusis
#2
REVIEW
Mabel K Yan, John Sm Chang, Tommy Cy Chan
Uncorrected refractive errors are a leading cause of visual impairment across the world. In today's society, laser in-situ keratomileusis (LASIK) has become the most commonly performed surgical procedure to correct refractive errors. However, regression of the initially-achieved refractive correction has been a widely-observed phenomenon following LASIK since its inception more than two decades ago. Despite technological advances in laser refractive surgery and various proposed management strategies, post-LASIK regression is still frequently observed and has significant implications for the long-term visual performance and quality of life of patients...
April 26, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29658834/alterations-in-thyroid-hormone-levels-following-growth-hormone-replacement-exert-complex-biological-effects
#3
Nigel Glynn, Helena Kenny, Tarik Salim, David J Halsall, Diarmuid Smith, Tommy Kyaw Tun, John H McDermott, William Tormey, Christopher J Thompson, Brendan McAdam, Donal O' Gorman, Amar Agha
OBJECTIVE: Alterations in the thyroid axis are frequently observed following growth hormone (GH) replacement, but uncertainty exists regarding their clinical significance. We aimed to compare fluctuations in circulating thyroid hormone levels, induced by GH, to changes in sensitive biological markers of thyroid hormone action. METHODS: This was a prospective observational clinical study. Twenty hypopituitary men were studied before and after GH replacement. Serum thyroid-stimulating hormone (TSH), thyroid hormones, and insulin-like growth factor 1 were measured...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29601208/performance-and-return-to-sport-after-tommy-john-surgery-among-major-league-baseball-position-players
#4
Robert A Jack, Matthew B Burn, Kyle R Sochacki, Patrick C McCulloch, David M Lintner, Joshua D Harris
BACKGROUND: The anterior bundle of the medial ulnar collateral ligament (UCL) is the primary restraint to valgus stress at the elbow and is often injured among overhead throwing athletes. Despite prevention strategies, injuries to the elbow UCL are on the rise. PURPOSE: To determine (1) the return-to-sport (RTS) rate of Major League Baseball (MLB) position players after elbow medial UCL reconstruction, (2) postoperative career length and games per season, (3) pre- and postoperative performance, (4) postoperative performance versus matched control players, and (5) whether position players changed positions after UCL reconstruction...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29531959/rationale-and-design-of-the-screening-of-pulmonary-hypertension-in-systemic-lupus-erythematosus-sophie-study
#5
Duo Huang, Yang-Yang Cheng, Pak-Hei Chan, Jojo Hai, Kai-Hang Yiu, Hung-Fat Tse, Ka-Lam Wong, Katherine Fan, Ying Wah Li, Woon-Leung Ng, Cheuk-Wan Yim, Cheuk-Hon John Wong, Lai-Shan Tam, Priscilla C H Wong, Chi-Yuen Wong, Chup-Hei Ho, Alexander M H Leung, Chi-Chiu Mok, Ho Lam, Chak-Sing Lau, Tommy Cheung, Carmen Ho, Sharon W Y Law, Esther W Chan, Li-Xue Yin, Wen-Sheng Yue, Toi Meng Mok, Mario Alberto Evora, Chung-Wah Siu
Current guideline-recommended screening for pulmonary hypertension in patients with systemic sclerosis has not been evaluated in systemic lupus erythematosus (SLE), which is disproportionately prevalent in Asians. This multicentre, cross-sectional screening study aims to study the prevalence of pulmonary hypertension among SLE patients using these guidelines, and identify independent predictors and develop a prediction model for pulmonary hypertension in SLE patients. SLE patients from participating centres will undergo an echocardiography- and biomarker-based pulmonary hypertension screening procedure as in the DETECT study...
January 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29520054/patient-derived-xenograft-cryopreservation-and-reanimation-outcomes-are-dependent-on-cryoprotectant-type
#6
Tommy Ivanics, John R Bergquist, Gang Liu, Michael P Kim, Yaan Kang, Matthew H Katz, Mayrim V Rios Perez, Ryan M Thomas, Jason B Fleming, Mark J Truty
Patient-derived xenografts (PDX) are being increasingly utilized in preclinical oncologic research. Maintaining large colonies of early generation tumor-bearing mice is impractical and cost-prohibitive. Optimal methods for efficient long-term cryopreservation and subsequent reanimation of PDX tumors are critical to any viable PDX program. We sought to compare the performance of "Standard" and "Specialized" cryoprotectant media on various cryopreservation and reanimation outcomes in PDX tumors...
March 8, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29496648/adjuvant-systemic-therapy-after-resection-of-node-positive-gallbladder-cancer-time-for-a-well-designed-trial-results-of-a-us-national-retrospective-cohort-study
#7
John R Bergquist, Harsh N Shah, Elizabeth B Habermann, Matthew C Hernandez, Tommy Ivanics, Michael L Kendrick, Rory L Smoot, David M Nagorney, Mitesh J Borad, Robert R McWilliams, Mark J Truty
BACKGROUND: Ideal oncologic management of gallbladder carcinoma (GBCA) after complete surgical resection is unclear. We sought to define benefit of post-resection adjuvant systemic chemotherapy alone in T2 or greater gallbladder carcinoma utilising a large national dataset. STUDY DESIGN: The National Cancer Data Base (NCDB) 2004-2012 cohort was retrospectively reviewed for patients with GBCA (T2+) undergoing curative-intent resection and surviving at least 6 weeks...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29396982/use-of-social-media-and-an-online-survey-to-discuss-complex-reconstructive-surgery-a-case-of-upper-lip-reconstruction-with-402-responses-from-international-microsurgeons
#8
Soo-Ha Kwon, Che-Hsiung Lee, Angela Ting-Wei Hsu, Mark Shafarenko, Usama Farghaly Omar, Chieh-Han John Tzou, Julia Roka-Palkovits, Aldo G Beltrán P, Dimitri Liakos, Tommy Nai-Jen Chang
BACKGROUND: The best reconstructive strategy for upper lip defects is still in debate. The purpose of this study was to analyze the decisions made by international microsurgeons, who were participated through online questionnaire, distributed by email and social media network. MATERIALS AND METHODS: A case of a two-thirds upper lip oncologic defect was presented via an online questionnaire and 402 microsurgeons replied their treatment options. The data were then analyzed according to the geographic area, microsurgical fellowship, seniority, and subspecialty...
February 2, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29363625/rapid-calibration-of-an-intracortical-brain-computer-interface-for-people-with-tetraplegia
#9
David M Brandman, Tommy Hosman, Jad Saab, Michael C Burkhart, Benjamin E Shanahan, John G Ciancibello, Anish A Sarma, Daniel J Milstein, Carlos E Vargas-Irwin, Brian Franco, Jessica Kelemen, Christine Blabe, Brian A Murphy, Daniel R Young, Francis R Willett, Chethan Pandarinath, Sergey D Stavisky, Robert F Kirsch, Benjamin L Walter, A Bolu Ajiboye, Sydney S Cash, Emad N Eskandar, Jonathan P Miller, Jennifer A Sweet, Krishna V Shenoy, Jaimie M Henderson, Beata Jarosiewicz, Matthew T Harrison, John D Simeral, Leigh R Hochberg
OBJECTIVE: Brain-computer interfaces (BCIs) can enable individuals with tetraplegia to communicate and control external devices. Though much progress has been made in improving the speed and robustness of neural control provided by intracortical BCIs, little research has been devoted to minimizing the amount of time spent on decoder calibration. APPROACH: We investigated the amount of time users needed to calibrate decoders and achieve performance saturation using two markedly different decoding algorithms: the steady-state Kalman filter, and a novel technique using Gaussian process regression (GP-DKF)...
April 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29361175/intratumor-heterogeneity-of-the-estrogen-receptor-and-the-long-term-risk-of-fatal-breast-cancer
#10
Linda S Lindström, Christina Yau, Kamila Czene, Carlie K Thompson, Katherine A Hoadley, Laura J Van't Veer, Ron Balassanian, John W Bishop, Philip M Carpenter, Yunn-Yi Chen, Brian Datnow, Farnaz Hasteh, Gregor Krings, Fritz Lin, Yanhong Zhang, Bo Nordenskjöld, Olle Stål, Christopher C Benz, Tommy Fornander, Alexander D Borowsky, Laura J Esserman
Background: Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors influencing this risk are unknown. We aimed to determine whether high intratumor heterogeneity of ER predicts an increased long-term risk (25 years) of fatal breast cancer. Methods: The STO-3 trial enrolled 1780 postmenopausal lymph node-negative breast cancer patients randomly assigned to receive adjuvant tamoxifen vs not...
January 19, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29349935/pitfalls-in-the-measurement-of-muscle-mass-a-need-for-a-reference-standard
#11
Fanny Buckinx, Francesco Landi, Matteo Cesari, Roger A Fielding, Marjolein Visser, Klaus Engelke, Stefania Maggi, Elaine Dennison, Nasser M Al-Daghri, Sophie Allepaerts, Jurgen Bauer, Ivan Bautmans, Maria Luisa Brandi, Olivier Bruyère, Tommy Cederholm, Francesca Cerreta, Antonio Cherubini, Cyrus Cooper, Alphonso Cruz-Jentoft, Eugene McCloskey, Bess Dawson-Hughes, Jean-Marc Kaufman, Andrea Laslop, Jean Petermans, Jean-Yves Reginster, René Rizzoli, Sian Robinson, Yves Rolland, Ricardo Rueda, Bruno Vellas, John A Kanis
BACKGROUND: All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. METHODS: Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia...
April 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29261249/real-world-economic-value-of-a-21-gene-assay-in-early-stage-breast-cancer
#12
Stanley E Waintraub, Donna McNamara, Deena Mary Atieh Graham, Andrew L Pecora, John Min, Tommy Wu, Hyun Gi Noh, Jacqueline Connors, Ruth Pe Benito, Kelly Choi, Eric Schultz, Stuart L Goldberg
OBJECTIVES: Value-based payment reforms shift cost-containment responsibilities to the physician. Although gene expression profiling (GEP) utilizing a 21-gene panel among patients with early-stage, axillary lymph node-negative, hormone receptor-positive, HER2/neu oncogene-negative breast cancer is able to identify a cohort that may achieve excellent outcomes without adjuvant chemotherapy, high up-front costs (list price, $4175) could dissuade usage. STUDY DESIGN: Retrospective review of consecutive patients with breast cancer treated at a single cancer center...
December 1, 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29248758/poor-cognitive-ageing-vulnerabilities-mechanisms-and-the-impact-of-nutritional-interventions
#13
REVIEW
Sophie Miquel, Claire Champ, Jon Day, Esther Aarts, Ben A Bahr, Martijntje Bakker, Diána Bánáti, Vittorio Calabrese, Tommy Cederholm, John Cryan, Louise Dye, Jonathan A Farrimond, Aniko Korosi, Sophie Layé, Stuart Maudsley, Dragan Milenkovic, M Hasan Mohajeri, John Sijben, Alina Solomon, Jeremy P E Spencer, Sandrine Thuret, Wim Vanden Berghe, David Vauzour, Bruno Vellas, Keith Wesnes, Peter Willatts, Raphael Wittenberg, Lucie Geurts
BACKGROUND: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated...
March 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29183332/a-novel-ruminococcus-gnavus-clade-enriched-in-inflammatory-bowel-disease-patients
#14
Andrew Brantley Hall, Moran Yassour, Jenny Sauk, Ashley Garner, Xiaofang Jiang, Timothy Arthur, Georgia K Lagoudas, Tommi Vatanen, Nadine Fornelos, Robin Wilson, Madeline Bertha, Melissa Cohen, John Garber, Hamed Khalili, Dirk Gevers, Ashwin N Ananthakrishnan, Subra Kugathasan, Eric S Lander, Paul Blainey, Hera Vlamakis, Ramnik J Xavier, Curtis Huttenhower
BACKGROUND: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract that is associated with changes in the gut microbiome. Here, we sought to identify strain-specific functional correlates with IBD outcomes. METHODS: We performed metagenomic sequencing of monthly stool samples from 20 IBD patients and 12 controls (266 total samples). These were taxonomically profiled with MetaPhlAn2 and functionally profiled using HUMAnN2...
November 28, 2017: Genome Medicine
https://www.readbyqxmd.com/read/29170662/-salmonella-in-peripheral-lymph-nodes-of-healthy-cattle-at-slaughter
#15
Hattie E Webb, Dayna M Brichta-Harhay, Mindy M Brashears, Kendra K Nightingale, Terrance M Arthur, Joseph M Bosilevac, Norasak Kalchayanand, John W Schmidt, Rong Wang, Sophie A Granier, Tyson R Brown, Thomas S Edrington, Steven D Shackelford, Tommy L Wheeler, Guy H Loneragan
To more fully characterize the burden of Salmonella enterica in bovine peripheral lymph nodes (PLN), PLN ( n = 5,450) were collected from healthy cattle at slaughter in 12 commercial abattoirs that slaughtered feedlot-fattened (FF) cattle exclusively ( n = 7), cattle removed (or culled) from breeding herds ( n = 3), or both FF and cull cattle ( n = 2). Qualitative and quantitative methods were used to estimate prevalence and concentration of Salmonella in PLN. Isolates were subjected to a variety of phenotypic, serological, and molecular assays...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28981289/using-curvature-power-to-map-the-domain-of-inverse-micellar-cubic-phases-the-case-of-aliphatic-aldehydes-in-1-2-dioleoyl-sn-glycero-3-phosphoethanolamine
#16
Jamie Burrell, Marcus K Dymond, Richard James Gillams, Duncan J Parker, G John Langley, Ana Maria Labrador, Tommy Nylander, George S Attard
Oxylipins, or fatty aldehydes, are a class of molecules produced from membrane lipids as a result of oxidative stress or enzyme-mediated peroxidation. Here we report the effects of two biologically important fatty aldehydes, trans, trans-2,4-decanedienal (DD) and cis-11-hexadecenal (HD), on the phase behaviour of the lipid 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in water. We compare the phase behaviour of DD/DOPE and HD/DOPE mixtures to the phase behaviour of oleic acid/ DOPE mixtures and show that DD, HD and oleic acid have similar effects on the phase diagrams of DOPE...
October 5, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28941595/lipidome-as-a-predictive-tool-in-progression-to-type-2-diabetes-in-finnish-men
#17
Tommi Suvitaival, Isabel Bondia-Pons, Laxman Yetukuri, Päivi Pöhö, John J Nolan, Tuulia Hyötyläinen, Johanna Kuusisto, Matej Orešič
BACKGROUND: There is a need for early markers to track and predict the development of type 2 diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In this study we tested whether the plasma molecular lipidome has biomarker potential to predicting the onset of T2DM. METHODS: We applied global lipidomic profiling on plasma samples from well-phenotyped men (107 cases, 216 controls) participating in the longitudinal METSIM study at baseline and at five-year follow-up...
January 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28924479/marked-hyperandrogenicity-in-a-60-year-old-woman
#18
Khaled Aljenaee, Sulaiman Ali, Seong Keat Cheah, Owen MacEneaney, Niall Mulligan, Neil Hickey, Tommy Kyaw Tun, Seamus Sreenan, John H McDermott
Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Her serum testosterone level was markedly elevated at 21 nmol/L (normal range: 0...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28887421/impact-of-raised-without-antibiotics-beef-cattle-production-practices-on-occurrences-of-antimicrobial-resistance
#19
Amit Vikram, Pablo Rovira, Getahun E Agga, Terrance M Arthur, Joseph M Bosilevac, Tommy L Wheeler, Paul S Morley, Keith E Belk, John W Schmidt
The specific antimicrobial resistance (AMR) decreases that can be expected from reducing antimicrobial (AM) use in United States (US) beef production have not been defined. To address this data gap, feces were recovered from 36 lots of "raised without antibiotics" (RWA) and 36 lots of "conventional" (CONV) beef cattle. Samples (N = 719) were collected during harvest and distributed over a year. AMR was assessed by: i) culture of six AM-resistant bacteria (ARB); ii) qPCR for 10 AMR genes (ARGs); iii) an qPCR array of 84 ARGs; and iv) metagenomic sequencing...
September 8, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28878267/carbonyl-reductase-1-catalyzes-20%C3%AE-reduction-of-glucocorticoids-modulating-receptor-activation-and-metabolic-complications-of-obesity
#20
Ruth A Morgan, Katharina R Beck, Mark Nixon, Natalie Z M Homer, Andrew A Crawford, Diana Melchers, René Houtman, Onno C Meijer, Andreas Stomby, Anna J Anderson, Rita Upreti, Roland H Stimson, Tommy Olsson, Tom Michoel, Ariella Cohain, Arno Ruusalepp, Eric E Schadt, Johan L M Björkegren, Ruth Andrew, Christopher J Kenyon, Patrick W F Hadoke, Alex Odermatt, John A Keen, Brian R Walker
Carbonyl Reductase 1 (CBR1) is a ubiquitously expressed cytosolic enzyme important in exogenous drug metabolism but the physiological function of which is unknown. Here, we describe a role for CBR1 in metabolism of glucocorticoids. CBR1 catalyzes the NADPH- dependent production of 20β-dihydrocortisol (20β-DHF) from cortisol. CBR1 provides the major route of cortisol metabolism in horses and is up-regulated in adipose tissue in obesity in horses, humans and mice. We demonstrate that 20β-DHF is a weak endogenous agonist of the human glucocorticoid receptor (GR)...
September 6, 2017: Scientific Reports
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