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https://www.readbyqxmd.com/read/28207955/can-an-injured-nerve-be-used-as-a-donor-nerve-for-distal-nerve-transfer-an-experimental-study-in-rats
#1
Chieh-Han John Tzou, Chuieng-Yi Johnny Lu, Tommy Naj-Jen Chang, David Chwei-Chin Chuang
BACKGROUND: Distal nerve transfer has proven efficacy. The purpose of this study was to investigate if an injured nerve can be used as a donor nerve for transfer, and to determine the threshold of injury. MATERIALS AND METHODS: Rat's left ulnar-nerves in the axilla with different degrees of injury were selected as the donor nerves for transfer, and the musculocutaneous-nerves the target nerves for being re-innervated. Six rats each served as positive and negative controls: Group A, intact ulnar-nerve transfer; and Group E, the ulnar-nerve was cut but no transfer...
February 16, 2017: Microsurgery
https://www.readbyqxmd.com/read/28112946/temporal-dynamics-of-in-field-bioreactor-populations-reflect-the-groundwater-system-and-respond-predictably-to-perturbation
#2
Andrew J King, Sarah P Preheim, Kathryn L Bailey, Michael S Robeson, Taniya Roy Chowdhury, Bryan R Crable, Richard A Hurt, Tonia L Mehlhorn, Kenneth A Lowe, Tommy J Phelps, Anthony V Palumbo, Craig C Brandt, Steven D Brown, Mircea Podar, Ping Zhang, William Andrew Lancaster, Farris L Poole, David B Watson, Matthew W W Fields, John-Marc Chandonia, Eric J Alm, Jizhong Zhou, Michael W W Adams, Terry C Hazen, Adam P Arkin, Dwayne A Elias
Temporal variability complicates testing the influences of environmental variability on microbial community structure and thus function. An in-field bioreactor system was developed to assess oxic versus anoxic manipulations on in-situ groundwater communities. Each sample was sequenced (16S SSU rRNA genes, average 10,000 reads) and biogeochemical parameters monitored by quantifying 53 metals, 12 organic acids, 14 anions and 3 sugars. Changes in dissolved oxygen (DO), pH, and other variables were similar across bioreactors...
January 23, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28080180/long-term-effects-on-the-incidence-of-second-primary-cancers-in-a-randomized-trial-of-two-and-five-years-of-adjuvant-tamoxifen
#3
Johan Rosell, Bo Nordenskjöld, Nils-Olof Bengtsson, Tommy Fornander, Thomas Hatschek, Henrik Lindman, Per-Olof Malmström, Arne Wallgren, Olle Stål, John Carstensen
BACKGROUND: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. MATERIAL AND METHODS: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cancer recurrence after two years of tamoxifen, and who were randomized to receive totally two or five years of therapy. RESULTS: Compared to patients randomized to two years of tamoxifen the incidence of contralateral breast cancer [hazard ratio (HR) 0...
January 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28070725/type-of-resection-whipple-vs-distal-does-not-affect-the-national-failure-to-provide-post-resection-adjuvant-chemotherapy-in-localized-pancreatic-cancer
#4
John R Bergquist, Tommy Ivanics, Christopher R Shubert, Elizabeth B Habermann, Rory L Smoot, Michael L Kendrick, David M Nagorney, Michael B Farnell, Mark J Truty
INTRODUCTION: Adjuvant chemotherapy improves survival after curative intent resection for localized pancreatic adenocarcinoma (PDAC). Given the differences in perioperative morbidity, we hypothesized that patients undergoing distal partial pancreatectomy (DPP) would receive adjuvant therapy more often those undergoing pancreatoduodenectomy (PD). METHODS: The National Cancer Data Base (2004-2012) identified patients with localized PDAC undergoing DPP and PD, excluding neoadjuvant cases, and factors associated with receipt of adjuvant therapy were identified...
January 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27893700/trans-presentation-of-il-6-by-dendritic-cells-is-required-for-the-priming-of-pathogenic-th17-cells
#5
Sylvia Heink, Nir Yogev, Christoph Garbers, Marina Herwerth, Lilian Aly, Christiane Gasperi, Veronika Husterer, Andrew L Croxford, Katja Möller-Hackbarth, Harald S Bartsch, Karl Sotlar, Stefan Krebs, Tommy Regen, Helmut Blum, Bernhard Hemmer, Thomas Misgeld, Thomas F Wunderlich, Juan Hidalgo, Mohamed Oukka, Stefan Rose-John, Marc Schmidt-Supprian, Ari Waisman, Thomas Korn
The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were essential for the generation of pathogenic TH17 cells. Using their IL-6 receptor α-chain (IL-6Rα), Sirpα(+) DCs trans-presented IL-6 to T cells during the process of cognate interaction. While ambient IL-6 was sufficient to suppress the induction of expression of the transcription factor Foxp3 in T cells, trans-presentation of IL-6 by DC-bound IL-6Rα (called 'IL-6 cluster signaling' here) was needed to prevent premature induction of interferon-γ (IFN-γ) expression in T cells and to generate pathogenic TH17 cells in vivo...
January 2017: Nature Immunology
https://www.readbyqxmd.com/read/27815781/health-effects-and-environmental-justice-concerns-of-exposure-to-uranium-in-drinking-water
#6
REVIEW
Laura Corlin, Tommy Rock, Jamie Cordova, Mark Woodin, John L Durant, David M Gute, Jani Ingram, Doug Brugge
We discuss the recent epidemiologic literature regarding health effects of uranium exposure in drinking water focusing on the chemical characteristics of uranium. While there is strong toxicologic evidence for renal and reproductive effects as well as DNA damage, the epidemiologic evidence for these effects in people exposed to uranium in drinking water is limited. Further, epidemiologic evidence is lacking for cardiovascular and oncogenic effects. One challenge in characterizing health effects of uranium in drinking water is the paucity of long-term cohort studies with individual level exposure assessment...
December 2016: Current Environmental Health Reports
https://www.readbyqxmd.com/read/27809356/the-effect-of-growth-hormone-replacement-on-the-thyroid-axis-in-patients-with-hypopituitarism-in-vivo-and-ex-vivo-studies
#7
Nigel Glynn, Helena Kenny, Leah Quisenberry, David J Halsall, Paul Cook, Tommy Kyaw Tun, John H McDermott, Diarmuid Smith, Christopher J Thompson, Donal J O'Gorman, Anita Boelen, Joaquin Lado-Abeal, Amar Agha
OBJECTIVE: Alterations in the hypothalamic-pituitary-thyroid axis have been reported following growth hormone (GH) replacement. The aim was to examine the relationship between changes in serum concentration of thyroid hormones and deiodinase activity in subcutaneous adipose tissue, before and after GH replacement. DESIGN: A prospective, observational study of patients receiving GH replacement as part of routine clinical care. PATIENTS: Twenty adult hypopituitary men...
November 3, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27745805/internet-resources-for-tommy-john-injuries-what-are-patients-reading
#8
Christine C Johnson, Grant H Garcia, Joseph N Liu, Jeffrey G Stepan, Ronak M Patel, Joshua S Dines
BACKGROUND: The quality of medical information on the Internet has come under scrutiny. This study investigates the quality, accuracy, and readability of online information regarding ulnar collateral ligament (UCL) injuries. METHODS: Three search terms ("elbow ulnar collateral ligament injury," "tommy john injury," and "pitcher's elbow") were entered into 3 Internet search engines. Three independent reviewers evaluated the content and accuracy of the information with a set of predetermined scoring criteria...
December 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27571922/research-update-for-articles-published-in-ejci-in-2014
#9
Rosa María Agra, Nasser M Al-Daghri, Lina Badimon, Vicente Bodi, Federico Carbone, Mao Chen, Judit Cubedo, Robin P F Dullaart, Sonia Eiras, Carmelo García-Monzón, Thomas Gary, Antonio Gnoni, Águeda González-Rodríguez, Thomas Gremmel, Franz Hafner, Tommi Hakala, Baotao Huang, Kelly Ickmans, Concetta Irace, Ivana Kholová, Nina Kimer, Ville Kytö, Winfried März, Tomasz Miazgowski, Søren Møller, Fabrizio Montecucco, Giampaolo Niccoli, Jo Nijs, Serkan Ozben, Tomris Ozben, Ioannis Papassotiriou, Maria Papastamataki, Marta Reina-Couto, Cesar Rios-Navarro, Andreas Ritsch, Shaun Sabico, Ian W Seetho, Anna Severino, Jussi Sipilä, Teresa Sousa, Aleksandra Taszarek, Federica Taurino, Uwe J F Tietge, Cesare Tripolino, Willemien Verloop, Michiel Voskuil, John P H Wilding
No abstract text is available yet for this article.
October 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27546172/mixed-hepatocellular-and-cholangiocarcinoma-a-rare-tumor-with-a-mix-of-parent-phenotypic-characteristics
#10
John R Bergquist, Ryan T Groeschl, Tommy Ivanics, Christopher R Shubert, Elizabeth B Habermann, Michael L Kendrick, Michael B Farnell, David M Nagorney, Mark J Truty, Rory L Smoot
BACKGROUND: Intrahepatic lesions of mixed hepatocellular (HCC) and intrahepatic cholangiocellular carcinoma (ICC) histology are rare. The aim was to describe the natural history of these tumors relative to monomorphic ICC or HCC utilizing the National Cancer Data Base (NCDB). METHODS: Patients with ICC, HCC, and mixed histology (cHCC-CCA) were identified in the NCDB (2004-2012). Inter-group comparisons were made. Kaplan-Meier and multivariable Cox Proportional Hazards analyzed overall survival...
November 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/27525185/chronic-ucl-injury-a-multimodal-approach-to-correcting-altered-mechanics-and-improving-healing-in-a-college-athlete-a-case-report
#11
Rachel Patrick, Josh McGinty, Ann Lucado, Beth Collier
BACKGROUND: Ulnar collateral ligament (UCL) tears and associated Tommy Johns surgical intervention from excessive and poor quality pitching has increased immensely-with more college and professional pitchers undergoing the surgery in 2014 alone than in the 1990s as a whole.(1) Faulty mechanics developed at young ages are often well-engrained by the late adolescent years and the minimal healing ability of the largely avascular UCL often leads to delayed safe return to sport.(2). PURPOSE: The purpose of this case study was to describe an innovative, multimodal approach to conservative management of a chronic UCL injury in a college-aged baseball pitcher...
August 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27495869/phase-3-evaluation-of-hp802-247-in-the-treatment-of-chronic-venous-leg-ulcers
#12
Robert S Kirsner, Wolfgang Vanscheidt, David H Keast, John C Lantis, Cyaandi R Dove, Shawn M Cazzell, Mher Vartivarian, Matthias Augustin, William A Marston, Nicholas D McCoy, D Innes Cargill, Tommy D Lee, Jaime E Dickerson, Herbert B Slade
In 2012 we reported promising results from a Phase 2 clinical trial of HP802-247, a novel spray-applied investigational treatment for chronic venous leg ulcers (VLU) consisting of human, allogeneic fibroblasts and keratinocytes. We now describe Phase 3 clinical testing of HP802-247, its failure to detect efficacy, and subsequent investigation into the root causes of the failure. Two randomized, controlled trials enrolled a total of 673 adult outpatients at 96 centers in North America and Europe. The primary endpoint was the proportion of ulcers with confirmed closure at the end of 12 weeks of treatment...
August 6, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27453469/human-srmatlas-a-resource-of-targeted-assays-to-quantify-the-complete-human-proteome
#13
Ulrike Kusebauch, David S Campbell, Eric W Deutsch, Caroline S Chu, Douglas A Spicer, Mi-Youn Brusniak, Joseph Slagel, Zhi Sun, Jeffrey Stevens, Barbara Grimes, David Shteynberg, Michael R Hoopmann, Peter Blattmann, Alexander V Ratushny, Oliver Rinner, Paola Picotti, Christine Carapito, Chung-Ying Huang, Meghan Kapousouz, Henry Lam, Tommy Tran, Emek Demir, John D Aitchison, Chris Sander, Leroy Hood, Ruedi Aebersold, Robert L Moritz
The ability to reliably and reproducibly measure any protein of the human proteome in any tissue or cell type would be transformative for understanding systems-level properties as well as specific pathways in physiology and disease. Here, we describe the generation and verification of a compendium of highly specific assays that enable quantification of 99.7% of the 20,277 annotated human proteins by the widely accessible, sensitive, and robust targeted mass spectrometric method selected reaction monitoring, SRM...
July 28, 2016: Cell
https://www.readbyqxmd.com/read/27439662/implications-of-ca19-9-elevation-for-survival-staging-and-treatment-sequencing-in-intrahepatic-cholangiocarcinoma-a-national-cohort-analysis
#14
John R Bergquist, Tommy Ivanics, Curtis B Storlie, Ryan T Groeschl, May C Tee, Elizabeth B Habermann, Rory L Smoot, Michael L Kendrick, Michael B Farnell, Lewis R Roberts, Gregory J Gores, David M Nagorney, Mark J Truty
BACKGROUND: Optimal management of patients with intrahepatic cholangiocarcinoma (ICCA) and elevated CA19-9 remains undefined. We hypothesized CA19-9 elevation above normal indicates aggressive biology and that inclusion of CA19-9 would improve staging discrimination. METHODS: The National Cancer Data Base (NCDB-2010-2012) was reviewed for patients with ICCA and reported CA19-9. Patients were stratified by CA19-9 above/below normal reference range. Unadjusted Kaplan-Meier and adjusted Cox-proportional-hazards analysis of overall survival (OS) were performed...
September 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27401932/early-health-economic-modelling-of-single-stage-cartilage-repair-guiding-implementation-of-technologies-in-regenerative-medicine
#15
Tommy S de Windt, Juliette C Sorel, Lucienne A Vonk, Michelle M A Kip, Maarten J Ijzerman, Daniel B F Saris
Both the complexity of clinically applied tissue engineering techniques for articular cartilage repair - such as autologous chondrocyte implantation (ACI) - plus increasing healthcare costs, and market competition, are forcing a shift in focus from two-stage to single-stage interventions that are more cost-effective. Early health economic models are expected to provide essential insight in the parameters driving the cost-effectiveness of new interventions before they are introduced into clinical practice. The present study estimated the likely incremental cost-effectiveness ratio (ICER) of a new investigator-driven single-stage procedure (IMPACT) compared with both microfracture and ACI, and identified those parameters that affect the cost-effectiveness...
July 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#16
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27177217/dust-is-the-dominant-source-of-heavy-metals-to-peat-moss-sphagnum-fuscum-in-the-bogs-of-the-athabasca-bituminous-sands-region-of-northern-alberta
#17
William Shotyk, Beatriz Bicalho, Chad W Cuss, M John M Duke, Tommy Noernberg, Rick Pelletier, Eiliv Steinnes, Claudio Zaccone
Sphagnum fuscum was collected from twenty-five ombrotrophic (rain-fed) peat bogs surrounding open pit mines and upgrading facilities of Athabasca Bituminous Sands (ABS) in northern Alberta (AB) in order to assess the extent of atmospheric contamination by trace elements. As a control, this moss species was also collected at a bog near Utikuma (UTK) in an undeveloped part of AB and 264km SW of the ABS region. For comparison, this moss was also collected in central AB, in the vicinity of the City of Edmonton which is approximately 500km to the south of the ABS region, from the Wagner Wetland which is 22km W of the City, from Seba Beach (ca...
July 2016: Environment International
https://www.readbyqxmd.com/read/27172277/whole-body-hyperthermia-for-the-treatment-of-major-depressive-disorder-a-randomized-clinical-trial
#18
Clemens W Janssen, Christopher A Lowry, Matthias R Mehl, John J B Allen, Kimberly L Kelly, Danielle E Gartner, Angelica Medrano, Tommy K Begay, Kelly Rentscher, Joshua J White, Andrew Fridman, Levi J Roberts, Megan L Robbins, Kay-U Hanusch, Steven P Cole, Charles L Raison
IMPORTANCE: Limitations of current antidepressants highlight the need to identify novel treatments for major depressive disorder. A prior open trial found that a single session of whole-body hyperthermia (WBH) reduced depressive symptoms; however, the lack of a placebo control raises the possibility that the observed antidepressant effects resulted not from hyperthermia per se, but from nonspecific aspects of the intervention. OBJECTIVE: To test whether WBH has specific antidepressant effects when compared with a sham condition and to evaluate the persistence of the antidepressant effects of a single treatment...
August 1, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27171519/small-cell-carcinoma-of-the-pancreas-a-surgical-disease
#19
Tommy Ivanics, John R Bergquist, Christopher R Shubert, Rory L Smoot, Elizabeth B Habermann, Mark J Truty
OBJECTIVES: Primary pancreatic small cell carcinomas (PSCCs) are rare, and benefits of surgery are unknown. Utilizing the National Cancer Data Base, surgical outcomes of PSCC were determined and compared with pancreatic ductal adenocarcinoma (PDAC). METHODS: Patients with histologically confirmed PSCC (n = 541) and PDAC (n = 156,733) were identified from the National Cancer Data Base (1998-2011). Parametric comparisons of patient and outcomes data were made. Unadjusted Kaplan-Meier and Cox proportional hazards analyses were performed...
May 11, 2016: Pancreas
https://www.readbyqxmd.com/read/27001411/an-evaluation-of-nursing-students-perceptions-on-the-efficacy-of-high-fidelity-clinical-simulation-to-enhance-their-confidence-understanding-and-competence-in-managing-psychiatric-emergencies
#20
Tommy Dickinson, John Hopton, Mark Pilling
No abstract text is available yet for this article.
May 2016: Journal of Clinical Nursing
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