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https://www.readbyqxmd.com/read/29651820/seroprevalence-of-opsonophagocytic-antibodies-against-serotype-ia-ib-ii-iii-and-v-group-b-streptococcus-among-korean-population
#1
Ji Hyen Lee, Han Wool Kim, Kyung Hyo Kim
BACKGROUND: Invasive Streptococcus agalactiae (group B streptococcus, GBS) infection most commonly occurs in infants; however, cases of GBS infection in adults, particularly in the elderly with significant underlying diseases, are being increasingly reported. We analyzed the serotype specific opsonophagocytic antibodies (the major mechanism of protection against GBS) in infants, adults, and the elderly. METHODS: The opsonization indices (OIs) of antibodies against serotype Ia, Ib, II, III, and V GBS were studied in 89 infants, 35 adults (age, 30-50 years), and 62 elderly individuals (age, 65-85 years) according to the University of Alabama at Birmingham GBS opsonophagocytic killing assay protocol (www...
April 16, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29649134/-gnothi-seauton-leveraging-the-host-response-to-improve-influenza-virus-vaccine-efficacy
#2
REVIEW
Hannah D Stacey, Neda Barjesteh, Jonathan P Mapletoft, Matthew S Miller
Vaccination against the seasonal influenza virus is the best way to prevent infection. Nevertheless, vaccine efficacy remains far from optimal especially in high-risk populations such as the elderly. Recent technological advancements have facilitated rapid and precise identification of the B and T cell epitopes that are targets for protective responses. While these discoveries have undoubtedly brought the field closer to "universal" influenza virus vaccines, choosing the correct antigen is only one piece of the equation...
April 12, 2018: Vaccines
https://www.readbyqxmd.com/read/29643881/urinary-tract-infections-in-the-geriatric-patients
#3
Yesim Alpay, Nevil Aykin, Pinar Korkmaz, Hakki Mustafa Gulduren, Figen Cevik Caglan
Objective: Urinary tract infections (UTI) are the second most common infection in geriatric population. This study investigated clinical findings, diagnostic approaches, complicating factors, prognosis, causative microorganisms and antimicrobial susceptibility in geriatric patients diagnosed with UTI. Methods: A total of 140 hospitalised patients with UTIs were evaluated within three years between January 2011-January 2015 at the Eskisehir Yunus Emre State Hospital...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643543/-airway-foreign-body-caused-by-aspiration-of-artificial-nasal-sponge-a-case-report
#4
T X Fu, X Wang, M L Liu
57-year-old male was admitted to hospital for severe headache and seizure attacks on November 6th, 2016. After radiology and spinal fluid examination, he was diagnosed with viral encephalitis and treated with antiviral medicine, antibiotics and mannitol, but he was in sustained unconsciousness and weak in expectorating. The patient was given oxygen through artificial nasal after bedside tracheotomy. At 1:00 am on January 12th, 2016, there was a sudden drop in blood pressure, heart rate and oxygen saturation with left lung breath sounds slightly lower than the other side...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29628687/megaprosthesis-versus-allograft-prosthesis-composite-for-massive-skeletal-defects
#5
REVIEW
Deepak Gautam, Rajesh Malhotra
Massive skeletal defects are encountered in the setting of tumors necessitating excision, failed total hip arthroplasty with periprosthetic bone loss, periprosthetic fracture, complex trauma, multiple failed osteosynthesis and infection. Reconstruction of the segmental defects poses a tremendous challenge to the orthopaedic surgeons. The goal of osseous reconstruction of these defects is to restore the bone length and function. Currently the most commonly employed methods for reconstruction are either a megaprosthesis or an Allograft Prosthesis Composite (APC)...
January 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29626296/real-world-efficacy-and-safety-of-ledipasvir-and-sofosbuvir-in-patients-with-hepatitis-c-virus-genotype-1-infection-a-nationwide-multicenter-study-by-the-japanese-red-cross-liver-study-group
#6
Keiji Tsuji, Masayuki Kurosaki, Jun Itakura, Nami Mori, Shintaro Takaki, Chitomi Hasebe, Takehiro Akahane, Kouji Joko, Hitoshi Yagisawa, Jirou Takezawa, Ryou Nakata, Atsunori Kusakabe, Yuji Kojima, Hiroyuki Kimura, Takashi Tamada, Haruhiko Kobashi, Akeri Mitsuda, Masahiko Kondou, Chikara Ogawa, Yasushi Uchida, Tetsuro Sohda, Ryouichi Narita, Namiki Izumi
BACKGROUND: We aimed to describe the real-world efficacy and safety of combination therapy with ledipasvir and sofosbuvir (LDV/SOF) for chronic hepatitis C virus (HCV) genotype 1 (GT1) infection. METHODS: This retrospective analysis of a prospective, nationwide, multicenter registry included GT1-infected patients treated with LDV/SOF for 12 weeks. We assessed the rate of sustained virological response at 12 weeks post-treatment (SVR12), incidence of adverse events, and serum markers of hepatocellular carcinoma (HCC)...
April 6, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29626027/lesson-of-the-month-1-massive-spontaneous-haematomas-in-an-elderly-man
#7
Francesco Fiorini, Louise Braddick, Hasnain Hashim, Robert M Ayto, Alana Jacobs, Yetunde Baoku, Shahir S Hamdulay
A 73-year-old man presented with bilateral leg pain and swelling, and no history of trauma or bleeding disorders. Clinical examination, biochemistry and magnetic resonance imaging of the thighs were suggestive of muscle haematomas. These progressed significantly during the admission, requiring blood transfusion. Normal vascular anatomy on computed tomography, renal and liver function, and absence of infection made a bleeding diathesis more likely. This may be caused by coagulation defects, platelet disorders and vascular fragility...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29626024/pyrexia-of-unknown-origin
#8
Cristina Fernandez, Nick J Beeching
The syndrome of pyrexia of unknown origin (PUO) was first defined in 1961 but remains a clinical challenge for many physicians. Different subgroups with PUO have been suggested, each requiring different investigative strategies: classical, nosocomial, neutropenic and HIV-related. This could be expanded to include the elderly as a fifth group. The causes are broadly divided into four groups: infective, inflammatory, neoplastic and miscellaneous. Increasing early use of positron emission tomography-computed tomography (PET-CT) and the development of new molecular and serological tests for infection have improved diagnostic capability, but up to 50% of patients still have no cause found despite adequate investigations...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29624886/burden-and-epidemiology-of-influenza-and-respiratory-syncytial-virus-associated-severe-acute-respiratory-illness-hospitalization-in-madagascar-2011-2016
#9
Joelinotahina H Rabarison, Stefano Tempia, Aina Harimanana, Julia Guillebaud, Norosoa H Razanajatovo, Maherisoa Ratsitorahina, Jean-Michel Heraud
BACKGROUND: Influenza and respiratory syncytial virus (RSV) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza- and RSV-associated hospitalization are limited in Africa. METHODS: We conducted hospital-based surveillance for laboratory-confirmed influenza- and RSV-associated severe acute respiratory illness (SARI) at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011-2016...
April 6, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29624866/factors-associated-with-recovery-delay-in-a-sample-of-patients-diagnosed-by-mers-cov-rrt-pcr-a-saudi-arabian-multicenter-retrospective-study
#10
Anwar E Ahmed, Hamdan Al-Jahdali, Mody Alaqeel, Salma S Siddiq, Hanan A Alsaab, Ezzeldin A Sakr, Hamed A Alyahya, Munzir M Alandonisi, Alaa T Subedar, Yosra Z Ali, Hazza Al Otaibi, Nouf M Aloudah, Salim Baharoon, Sameera Al Johani, Mohammed G Alghamdi
AIM: Research evidence exists that poor prognosis is common in Middle East Respiratory Syndrome Coronavirus (MERS-CoV) patients. This study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected MERS-CoV and diagnosed by rRT-PCR assay. METHOD: A multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by rRT-PCR procedures to have MERS-CoV and non-MERS-CoV infection in which 396 achieved recovery...
April 6, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29623673/the-relationship-between-age-and-chronic-kidney-disease-in-patients-undergoing-pancreatic-resection
#11
Derrick Antoniak, Chandrakanth Are, Chad Vokoun, Kaeli Samson, Lynette Smith, Jason Shiffermiller
BACKGROUND: Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65. METHODS: Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Primary outcomes were all-cause mortality and major complication, defined as myocardial infarction, cardiac arrest, stroke, venous thromboembolism, respiratory failure, deep surgical site infection, pneumonia, acute kidney injury, coma > 24 h, or re-operation occurring within 30 days of surgery...
April 5, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29621602/neutrophil-extracellular-traps-possess-anti-human-respiratory-syncytial-virus-activity-possible-interaction-with-the-viral-f-protein
#12
Priscila Silva Sampaio Souza, Lia Vezenfard Barbosa, Larissa Figueiredo Alves Diniz, Gabriel Soares da Silva, Bruno Rafael Pereira Lopes, Pedro Miyadaira Ribeiro Souza, Gabriela Campos de Araujo, Diogo Pessoa, Juliana de Oliveira, Fátima Pereira Souza, Karina Alves Toledo
Human respiratory syncytial virus (hRSV) is one of the main etiological agents of diseases of the lower respiratory tract, and is often responsible for the hospitalization of children and the elderly. To date, treatments are only palliative and there is no vaccine available. The airways of patients infected with hRSV exhibit intense neutrophil infiltration, which is responsible for the release of neutrophil extracellular traps (NETs). These are extracellular structures consisting of DNA associated with intracellular proteins, and are efficient in capturing and eliminating various microorganisms, including some viruses...
April 2, 2018: Virus Research
https://www.readbyqxmd.com/read/29617492/influence-of-advanced-age-on-postoperative-outcomes-and-total-loss-following-breast-reconstruction-a-critical-assessment-of-560-cases
#13
Walter Koiti Matsumoto, Alexandre Mendonça Munhoz, Alberto Okada, Eduardo Montag, Eduardo Gustavo Arruda, Alexandre Fonseca, Orlando Ferrari, José Augusto Brasil, Lia Pretti, José Roberto Filassi, Rolf Gemperli
OBJECTIVE: to evaluate the role of age in the risk of postoperative complications in patients submitted to unilateral breast reconstruction after mastectomy, with emphasis on total reconstruction loss. METHODS: we conducted a retrospective study of patients submitted to breast reconstruction, whose variables included: oncological and reconstruction data, postoperative complications, including loss of reconstruction and complications of surgical wound. We divided the patients into two groups, according to the classification of the Brazilian National Elderly Policy and the Statute of the Elderly: young (age <60 years) and elderly (60 years or more)...
March 29, 2018: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29616390/the-impact-of-aging-on-cd4-t-cell-responses-to-influenza-infection
#14
REVIEW
Erica C Lorenzo, Jenna M Bartley, Laura Haynes
CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearance and prolonged inflammation leading to increased pathology. Current research employing animal models and human subjects has provided new insights into the description and mechanisms of age-related CD4+ T cell changes...
April 3, 2018: Biogerontology
https://www.readbyqxmd.com/read/29609923/evaluation-on-clinical-efficacy-of-fuzheng-jiedu-huayu-decoction-combined-with-antibiotics-in-the-treatment-of-pneumonia-in-the-elderly-a-multi-center-double-blind-parallel-randomized-controlled-trial
#15
Hongri Xu, Meng Li, Chengxiang Wang, Renyi Yin, Jie Ma, Mingzhe Wang, Quan Ming Tan, Liangduo Jiang, Miao Cheng, Xianhai Chen, Lishan Zhang, Huiping Su, Ruifu Hao, Yang Jiao, Caihua Wang, Hanlin Wei, Cuiling Feng, Hui Luo, Chuanyun Ren, Shaozhong Zhou, Shengxian Wu, Pingan Zhou
OBJECTIVE: To evaluate the efficacy and safety of Fuzheng Jiedu Huayu Decoction (FJHD) in treating pneumonia in the elderly. METHODS: Adopting a multi-center, double-blind, parallel, randomized controlled trial, 284 elderly pneumonia patients were enrolled and randomly allocated to the standard treatment with FJHD (treatment group, TG) and the standard treatment with placebo group (control group, CG). Efficacy and safety was evaluated through mortality rate, curative rate, symptom improvement, chest X-ray (CXR) lesion absorption, arterial blood gas (ABG), peripheral blood leukocyte count (PBLC) and adverse events...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29608971/more-intensive-cmv-infection-in-chronic-heart-failure-patients-contributes-to-higher-t-lymphocyte-differentiation-degree
#16
Marco Antonio Moro-García, Fernando López-Iglesias, Raquel Marcos-Fernández, Eva Bueno-García, Beatriz Díaz-Molina, José Luis Lambert, Francisco Manuel Suárez-García, Cesar Morís de la Tassa, Rebeca Alonso-Arias
Immunosenescence in chronic heart failure (CHF) is characterized by a high frequency of differentiated T-lymphocytes, contributing to an inflammatory status and a deficient ability to generate immunocompetent responses. CMV is the best known inducer of T-lymphocyte differentiation, and is associated with the phenomenon of immunosenescence. In this study, we included 58 elderly chronic heart failure patients (ECHF), 60 healthy elderly controls (HEC), 40 young chronic heart failure patients (YCHF) and 40 healthy young controls (HYC)...
March 30, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29605709/intra-peri-and-postoperative-complications-in-pelvic-organ-prolapse-surgery-in-geriatric-women
#17
Marc Körnig, Esther Brühlmann, Andreas Günthert, Corina Christmann
OBJECTIVE: Pelvic organ prolapse is a common problem among geriatric women. Advanced age is associated with a high prevalence of comorbidities that can lead to restrictive use of surgical treatment. With rising life expectancy it is predicted that surgical treatment in these women will be seen more frequently. Inconsistently there is a lack of clinical trials giving attention to elderly women suffering from pelvic organ prolapse. The aim of this study was to quantify the rate of complications in elderly women undergoing surgery for pelvic organ prolapse...
March 23, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29605189/outbreak-of-invasive-group-a-streptococcus-investigations-using-agar-settle-plates-detects-perineal-shedding-from-a-healthcare-worker
#18
Nikunj Mahida, Katie Prescott, Carl Yates, Fay Spencer, Vivienne Weston, Tim Boswell
BACKGROUND: Outbreaks of group A streptococcus (GAS) infections can occur in healthcare settings. Transmission to patients is sometimes linked to colonised healthcare workers and/or a contaminated environment. AIM: This report describes the investigation and control of an outbreak of healthcare-associated GAS on an elderly care medical ward, over six months. METHODS: Four patients developed septicaemia due to GAS infection without a clinically obvious site of infection...
March 29, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29605057/first-nations-people-s-perspectives-on-barriers-and-supports-for-enhancing-hpv-vaccination-foundations-for-sustainable-community-driven-strategies
#19
R I Henderson, M Shea-Budgell, C Healy, A Letendre, L Bill, B Healy, R A Bednarczyk, K Mrklas, C Barnabe, J Guichon, N Bedingfield, S MacDonald, A Colquhoun, S Glaze, T Nash, C Bell, J Kellner, R Richardson, T Dixon, J Starlight, G Runner, G Nelson
OBJECTIVE: In Canada, Indigenous people have higher human papillomavirus (HPV) infection rates, lower screening rates for cervical cancer, and higher rates of invasive cancer, leading to worse cervical cancer-related outcomes than observed in non-Indigenous Canadian women. Lingering harms from European colonization drive these health inequities and create public health challenges. Policy guidance is needed to optimize HPV vaccination rates and, thereby, decrease the burden of HPV-related illness, including high-morbidity surgical procedures and chemo-radiotherapy...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29605009/troglostrongylus-brevior-a-feline-lungworm-of-paediatric-concern
#20
Maria Alfonsa Cavalera, Roberta Iatta, Vito Colella, Filipe Dantas-Torres, Angelo Corsaro, Emanuele Brianti, Domenico Otranto
The immature immune system of cats in their paediatric age (i.e., first six months of life) favours the establishment of infectious respiratory tract diseases mainly caused by well recognized viruses and bacteria species. Conversely, lungworm infections are less investigated during respiratory disorders in kittens. In the last decade, Troglostrongylus brevior has been found affecting the respiratory tract of cats, along with the better-known Aelurostrongylus abstrusus. Given the scant data available on the epidemiology of feline troglostrongylosis, faecal samples from 575 domestic animals living in three Italian municipalities (i...
April 15, 2018: Veterinary Parasitology
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