María Alejandra Restrepo-Córdoba, Przemyslaw Chmielewski, Grażyna Truszkowska, María Luisa Peña-Peña, Miloš Kubánek, Alice Krebsová, Luis R Lopes, Álvaro García-Ropero, Marco Merlo, Alessia Paldino, Stacey Peters, Ruxandra Jurcut, Roberto Barriales-Villa, Esther Zorio, Mark Hazebroek, Jens Mogensen, Pablo García-Pavía
INTRODUCTION AND OBJECTIVES: Limited information is available on the safety of pregnancy in patients with genetic dilated cardiomyopathy (DCM) and in carriers of DCM-causing genetic variants without the DCM phenotype. We assessed cardiac, obstetric, and fetal or neonatal outcomes in this group of patients. METHODS: We studied 48 women carrying pathogenic or likely pathogenic DCM-associated variants (30 with DCM and 18 without DCM) who had 83 pregnancies. Adverse cardiac events were defined as heart failure (HF), sustained ventricular tachycardia, ventricular assist device implantation, heart transplant, and/or maternal cardiac death during pregnancy, or labor and delivery, and up to the sixth postpartum month...
April 17, 2024: Revista Española de Cardiología