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https://www.readbyqxmd.com/read/29346645/performance-of-an-easy-to-use-prediction-model-for-renal-patient-survival-an-external-validation-study-using-data-from-the-era-edta-registry
#1
Aline C Hemke, Martin B A Heemskerk, Merel van Diepen, Anneke Kramer, Johan de Meester, James G Heaf, José Maria Abad Diez, Marta Torres Guinea, Patrik Finne, Philippe Brunet, Bjørn E Vikse, Fergus J Caskey, Jamie P Traynor, Ziad A Massy, Cécile Couchoud, Jaap W Groothoff, Maurizio Nordio, Kitty J Jager, Friedo W Dekker, Andries J Hoitsma
Background: An easy-to-use prediction model for long-term renal patient survival based on only four predictors [age, primary renal disease, sex and therapy at 90 days after the start of renal replacement therapy (RRT)] has been developed in The Netherlands. To assess the usability of this model for use in Europe, we externally validated the model in 10 European countries. Methods: Data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry were used...
January 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29346031/2016-new-horizons-lecture-beyond-imaging-radiology-of-tomorrow
#2
Hedvig Hricak
This article is based on the New Horizons lecture delivered at the 2016 Radiological Society of North America Annual Meeting. It addresses looming changes for radiology, many of which stem from the disruptive effects of the Fourth Industrial Revolution. This is an emerging era of unprecedented rapid innovation marked by the integration of diverse disciplines and technologies, including data science, machine learning, and artificial intelligence-technologies that narrow the gap between man and machine. Technologic advances and the convergence of life sciences, physical sciences, and bioengineering are creating extraordinary opportunities in diagnostic radiology, image-guided therapy, targeted radionuclide therapy, and radiology informatics, including radiologic image analysis...
January 18, 2018: Radiology
https://www.readbyqxmd.com/read/29345754/long-term-follow-up-after-full-split-liver-transplantation-and-its-applicability-in-the-recent-transplant-era
#3
Uta Herden, Lutz Fischer, Martina Sterneck, Enke Grabhorn, Bjoern Nashan
INTRODUCTION: Full-split liver transplantation (LTX) offers the possibility to expand the donor pool by utilization of one liver for two adults. The aim of our study was to analyse the long-term outcome in a large series and its applicability in the recent transplant era. METHODS: We performed a retrospective analysis of all full-split LTX from deceased donors (1999-2015). Additionally, the potential of full-split LTX was retrospectively analysed in all whole organ LTX recipients between 2006 and 2015 (after introduction of the MELD allocation)...
January 18, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29345590/what-is-the-role-for-glycoprotein-iib-iiia-inhibitor-use-in-the-catheterisation-laboratory-in-the-current-era
#4
Andrea Rubboli, Giuseppe Patti
BACKGROUND: In the era of dual antiplatelet therapy of aspirin and clopidogrel and systematic stent implantation, glycoprotein IIb/IIIa inhibitors (GPI), including abciximab, eptifibatide and tirofiban, proved beneficial in improving early outcome of percutaneous coronary intervention (PCI), especially in higher risk clinical and/or anatomical subsets. This was associated however, with an increased incidence of bleeding complications. OBJECTIVE: To review whether the established results of GPI in PCI are maintained in the contemporary era of more effective antiplatelet agents (i...
January 16, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29345254/the-mtor-inhibitor-azd8055-overcomes-tamoxifen-resistance-in-breast-cancer-cells-by-down-regulating-hspb8
#5
Jia-Jie Shi, Si-Meng Chen, Chen-Liang Guo, Yi-Xue Li, Jian Ding, Ling-Hua Meng
Tamoxifen, an important endocrine therapeutic agent, is widely used for the treatment of estrogen receptor positive (ER+) breast cancer. However, de novo or acquired resistance prevents patients from benefitting from endocrine approaches and necessitates alternative treatments. In this study, we report that small heat protein beta-8 (HSPB8) may serve as an important molecule in tamoxifen resistance. HSPB8 expression is enhanced in MCF-7 cells resistant to tamoxifen (MCF-7/R) compared to parent cells. Moreover, high expression of HSPB8 associates with poor prognosis in ER+ breast cancer patients but not in patients without classification...
January 18, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29345081/screening-for-latent-tuberculosis-infection-among-patients-with-rheumatoid-arthritis-in-the-era-of-biologics-and-targeted-synthetic-disease-modifying-anti-rheumatic-drugs-in-india-a-high-burden-tb-country-the-importance-of-mantoux-and-quantiferon-tb-gold-tests
#6
Anand N Malaviya, Vishal K Aggarwal, Roopa Rawat, Sadhana Baghel, Ravita Thakran, Qamar Zaheer, Shriram Garg, Sanjiv Kapoor
AIM: To test the validity of an augmented tuberculosis skin test (a-TST) combined with Quantiferon TB-gold® (QFTG) test for the screening of latent tuberculosis infection (LTBI) in patients with rheumatoid arthritis (RA) being considered for treatment with biologic disease-modifying anti-rheumatic drugs or targeted synthetic disease-modifying anti-rheumatic drugs. METHOD: Standard TST using 1 tuberculin unit (TU) of purified protein derivative (PPD, RT23 strain) was carried out...
January 17, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29344885/microrna-networks-in-breast-cancer-cells
#7
Andliena Tahiri, Miriam R Aure, Vessela N Kristensen
A variety of molecular techniques can be used in order to unravel the molecular composition of cells. In particular, the microarray technology has been used to identify novel biomarkers that may be useful in the diagnosis, prognosis, or treatment of cancer. The microarray technology is ideal for biomarker discovery as it allows for the screening of a large number of molecules at once. In this review, we focus on microRNAs (miRNAs) which are key molecules in cells and regulate gene expression post-transcriptionally...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29344776/dawning-of-a-new-era-in-trp-channel-structural-biology-by-cryo-electron-microscopy
#8
REVIEW
M Gregor Madej, Christine M Ziegler
Cryo-electron microscopy (cryo-EM) permits the determination of atomic protein structures by averaging large numbers of individual projection images recorded at cryogenic temperatures-a method termed single-particle analysis. The cryo-preservation traps proteins within a thin glass-like ice layer, making literally a freeze image of proteins in solution. Projections of randomly adopted orientations are merged to reconstruct a 3D density map. While atomic resolution for highly symmetric viruses was achieved already in 2009, the development of new sensitive and fast electron detectors has enabled cryo-EM for smaller and asymmetrical proteins including fragile membrane proteins...
January 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29344752/transforming-dermatologic-imaging-for-the-digital-era-metadata-and-standards
#9
Liam J Caffery, David Clunie, Clara Curiel-Lewandrowski, Josep Malvehy, H Peter Soyer, Allan C Halpern
Imaging is increasingly being used in dermatology for documentation, diagnosis, and management of cutaneous disease. The lack of standards for dermatologic imaging is an impediment to clinical uptake. Standardization can occur in image acquisition, terminology, interoperability, and metadata. This paper presents the International Skin Imaging Collaboration position on standardization of metadata for dermatologic imaging. Metadata is essential to ensure that dermatologic images are properly managed and interpreted...
January 17, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29344433/one-click-away-digital-mentorship-in-the-modern-era
#10
REVIEW
Michael Gottlieb, Abra Fant, Andrew King, Anne Messman, Daniel Robinson, Guy Carmelli, Jonathan Sherbino
Mentorship is a valuable component of the career development of junior faculty. The digital era has allowed for greater access to mentors spanning geographic barriers and time zones. This article discusses the concept of digital mentorship, as well as strategies and techniques for developing and supporting a digital mentoring relationship in the modern era.
November 11, 2017: Curēus
https://www.readbyqxmd.com/read/29343870/-la-legge-italiana-n-24-2017-sulla-responsabilit%C3%A3-penale-del-medico-una-riforma-che-non-risolve-i-problemi-della-pratica-psichiatrica
#11
Gianluca Montanari Vergallo, Simona Zaami, Natale Mario Di Luca, Giuseppe Bersani, Raffaella Rinaldi
RIASSUNTO. Da anni gli psichiatri vivono in maniera pressante il rischio di essere sottoposti a processo penale per responsabilità professionale. Una delle ragioni di questa situazione sta nel fatto che il professionista non può contare su regole di comportamento chiare. Anzi, proprio in psichiatria è possibile che un giudice consideri colposa una condotta che per un altro Tribunale non è sanzionabile, come nei casi di dimissioni ospedaliere. Per rimediare a questa situazione il legislatore italiano ha emanato la legge 8 marzo 2017, n...
November 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29343672/applying-the-seattle-heart-failure-model-in-the-office-setting-in-the-era-of-electronic-medical-records
#12
Brent A Williams, Shikhar Agarwal
BACKGROUND: Prediction models such as the Seattle Heart Failure Model (SHFM) can help guide management of heart failure (HF) patients, but the SHFM has not been validated in the office environment. This retrospective cohort study assessed the predictive performance of the SHFM among patients with new or pre-existing HF in the context of an office visit.Methods and Results:SHFM elements were ascertained through electronic medical records at an office visit. The primary outcome was all-cause mortality...
January 18, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29343505/revisiting-criteria-for-plant-mirna-annotation-in-the-era-of-big-data
#13
Michael J Axtell, Blake C Meyers
No abstract text is available yet for this article.
January 17, 2018: Plant Cell
https://www.readbyqxmd.com/read/29343260/liquid-biomarkers-in-melanoma-detection-and-discovery
#14
REVIEW
Su Yin Lim, Jenny H Lee, Russell J Diefenbach, Richard F Kefford, Helen Rizos
A vast array of tumor-derived genetic, proteomic and cellular components are constantly released into the circulation of cancer patients. These molecules including circulating tumor DNA and RNA, proteins, tumor and immune cells are emerging as convenient and accurate liquid biomarkers of cancer. Circulating cancer biomarkers provide invaluable information on cancer detection and diagnosis, prognosticate patient outcomes, and predict treatment response. In this era of effective molecular targeted treatments and immunotherapies, there is now an urgent need to implement use of these circulating biomarkers in the clinic to facilitate personalized therapy...
January 17, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29343086/percutaneous-nephrolithotomy-and-spina-bifida-complex-major-stone-surgery
#15
Stephen Mitchell, Pratik Gurung, Simon Choong, Timothy Morris, Daron Smith, Christopher Woodhouse, Timothy Philp
Background The incidence of spina bifida (SB) is approx 1:1000, and risk of stone disease is substantially raised in SB. This is the unique published study of the outcome of patients with SB undergoing percutaneous nephrolithotomy (PCNL) compared to a neurologically intact historically matched control group at the same institution. Patients and Method A series of 96 PCNLs in 13 SB and 50 non-SB control patients was analysed. The following measurements were recorded: (1) Co-morbidities; (2) Pre-operative: (renal function, American Society of Anesthesiologists (ASA) score); (3) Intra-operative: (anaesthesia time, number of tracks, stone free rate) and (4) Post-operative: (sepsis, intensive therapy unit (ITU) and total length of stay, transfusion rate, stone composition, rate of stone disease-related nephrectomy)...
January 17, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29342498/patient-reminder-and-recall-interventions-to-improve-immunization-rates
#16
REVIEW
Julie C Jacobson Vann, Robert M Jacobson, Tamera Coyne-Beasley, Josephine K Asafu-Adjei, Peter G Szilagyi
BACKGROUND: Immunization rates for children and adults are rising, but coverage levels have not reached optimal goals. As a result, vaccine-preventable diseases still occur. In an era of increasing complexity of immunization schedules, rising expectations about the performance of primary care, and large demands on primary care providers, it is important to understand and promote interventions that work in primary care settings to increase immunization coverage. One common theme across immunization programs in many nations involves the challenge of implementing a population-based approach and identifying all eligible recipients, for example the children who should receive the measles vaccine...
January 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29342202/cells-containing-aragonite-crystals-mediate-responses-to-gravity-in-trichoplax-adhaerens-placozoa-an-animal-lacking-neurons-and-synapses
#17
Tatiana D Mayorova, Carolyn L Smith, Katherine Hammar, Christine A Winters, Natalia B Pivovarova, Maria A Aronova, Richard D Leapman, Thomas S Reese
Trichoplax adhaerens has only six cell types. The function as well as the structure of crystal cells, the least numerous cell type, presented an enigma. Crystal cells are arrayed around the perimeter of the animal and each contains a birefringent crystal. Crystal cells resemble lithocytes in other animals so we looked for evidence they are gravity sensors. Confocal microscopy showed that their cup-shaped nuclei are oriented toward the edge of the animal, and that the crystal shifts downward under the influence of gravity...
2018: PloS One
https://www.readbyqxmd.com/read/29341994/understanding-tuberculosis-in-an-era-of-global-travel
#18
Ramona A Benkert, Ann Clifton
With the resurgence of tuberculosis (TB), it is imperative that healthcare providers have the necessary skills to manage the specialized issues of prevention, recognition, and treatment of TB. The case study in this article illustrates these skills for NPs and other advanced practice providers.
February 16, 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29341970/does-the-use-of-indirect-calorimetry-change-outcome-in-the-icu-yes-it-does
#19
Elisabeth De Waele, Patrick M Honoré, Manu L N G Malbrain
PURPOSE OF REVIEW: To review the recent findings on metabolic monitoring and possible beneficial effects of an adequate nutrition therapy, based on indirect calorimetry as the golden standard to predict energy expenditure. RECENT FINDINGS: in the last decades, major steps are taken in the field of metabolism and nutrition, evolving from nutrition as a baseline support to a therapeutic intervention. The aspect of energy expenditure is of cardinal importance, and technical possibilities have impressively improved: from the first 'calorimetre' in 1789 to the new generation, clinical applicable indirect calorimeters and the high accuracy and easy use model reaching high technology readiness level [Oshima et al...
January 15, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29341290/early-failure-of-kidney-transplants-in-the-current-era-a-national-cohort-study
#20
Ilkka Helanterä, Juulia Räihä, Patrik Finne, Marko Lempinen
Although short-term outcome after kidney transplantation has improved, a small proportion of grafts are lost during the first year. We characterize in detail all early graft losses in the current era in a nationwide cohort of kidney transplant recipients. Altogether 2447 kidney transplantations, performed between June 2004 and October 2016, were included. All graft losses (return to dialysis or patient death) occurring during the first posttransplant year were characterized. During the first posttranplant year altogether 109 grafts were lost, 67 grafts failed, and 42 patients died...
January 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
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