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https://www.readbyqxmd.com/read/28935624/the-brain-thermal-response-as-a-potential-neuroimaging-biomarker-of-cerebrovascular-impairment
#1
C C Fleischer, J Wu, D Qiu, S-E Park, F Nahab, S Dehkharghani
BACKGROUND AND PURPOSE: Brain temperature is critical for homeostasis, relating intimately to cerebral perfusion and metabolism. Cerebral thermometry is historically challenged by the cost and invasiveness of clinical and laboratory methodologies. We propose the use of noninvasive MR thermometry in patients with cerebrovascular disease, hypothesizing the presence of a measurable brain thermal response reflecting the tissue hemodynamic state. MATERIALS AND METHODS: Contemporaneous imaging and MR thermometry were performed in 10 patients (32-68 years of age) undergoing acetazolamide challenge for chronic, anterior circulation steno-occlusive disease...
September 21, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28935168/intimate-partner-violence-and-psychotic-experiences-in-four-u-s-cities
#2
Roma Shah, Tara Von Mach, Lisa Fedina, Bruce Link, Jordan DeVylder
BACKGROUND: A large body of research has established a relationship between trauma exposure, particularly during childhood, and psychotic experiences. Yet, there remains a general lack of research on adult trauma exposure, including intimate partner violence (IPV), as a risk factor for psychotic experiences. The purpose of this study is to investigate the association between IPV and psychotic experiences in U.S. cities. METHODS: Data were collected from 1615 participants in four U...
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28933950/women-s-experiences-of-pornography-a-systematic-review-of-research-using-qualitative-methods
#3
Sarah Ashton, Karalyn McDonald, Maggie Kirkman
Given the proliferation of pornography in personal, relational, and social realms, it is vital to understand women's experiences of this accessible, stimulating, and versatile sexual material. We therefore conducted the first systematic review of research using qualitative methods published in English in peer-reviewed journals. Our search of five databases yielded 22 eligible articles. Thematic analysis of results revealed four broad themes: women encountering pornography, pornography and the self, pornography in the context of relationships, and making sense of pornography...
September 21, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28933602/lactoferrin-structure-function-denaturation-and-digestion
#4
Bo Wang, Yakindra Prasad Timilsena, Ewan Blanch, Benu Adhikari
Lactoferrin (LF) is a multifunctional protein occurring in many biological secretions including milk. It possesses iron binding/transferring, antibacterial, antiviral, antifungal, anti-inflammatory and anti-carcinogenic properties. These functional properties intimately depend on the structural integrity of LF especially its higher order conformation. LF is primarily extracted from bovine milk and it is subsequently added into many commercial products such as nutritional supplements, infant formula, cosmetics and toothpaste...
September 21, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28930437/c-and-n-metalated-nitriles-the-relationship-between-structure-and-selectivity
#5
Xun Yang, Fraser F Fleming
Metalated nitriles are exceptional nucleophiles capable of forging highly hindered stereocenters in cases where enolates are unreactive. The excellent nucleophilicity emanates from the powerful inductive stabilization of adjacent negative charge by the nitrile, which has a miniscule steric demand. Inductive stabilization is the key to understanding the reactivity of metalated nitriles because this permits a continuum of structures that range from N-metalated ketenimines to nitrile anions. Solution and solid-state analyses reveal two different metal coordination sites, the formally anionic carbon and the nitrile nitrogen, with the site of metalation depending intimately on the solvent, counterion, temperature, and ligands...
September 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28930051/addiction-and-the-role-of-circadian-genes
#6
Laura A Forde, Gursharan Kalsi
OBJECTIVE: In mammals, intimate interactions exist between the circadian system and other molecular systems, and mounting evidence is suggesting that these relationships may affect substance use disorders. Research in preclinical models supports the role of circadian genes as risk factors for addiction. Here, we explore the evidence and review human genetic studies testing the association between specific circadian genes and substance use disorders. METHOD: A literature search was conducted in PubMed for studies testing variants in eight circadian genes known to be central to the functioning of the master clock in the brain...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28928959/cell-polarity-cell-adhesion-and-spermatogenesis-role-of-cytoskeletons
#7
REVIEW
Linxi Li, Ying Gao, Haiqi Chen, Tito Jesus, Elizabeth Tang, Nan Li, Qingquan Lian, Ren-Shan Ge, C Yan Cheng
In the rat testis, studies have shown that cell polarity, in particular spermatid polarity, to support spermatogenesis is conferred by the coordinated efforts of the Par-, Crumbs-, and Scribble-based polarity complexes in the seminiferous epithelium. Furthermore, planar cell polarity (PCP) is conferred by PCP proteins such as Van Gogh-like 2 (Vangl2) in the testis. On the other hand, cell junctions at the Sertoli cell-spermatid (steps 8-19) interface are exclusively supported by adhesion protein complexes (for example, α6β1-integrin-laminin-α3,β3,γ3 and nectin-3-afadin) at the actin-rich apical ectoplasmic specialization (ES) since the apical ES is the only anchoring device in step 8-19 spermatids...
2017: F1000Research
https://www.readbyqxmd.com/read/28927262/autophagy-is-pro-senescence-when-seen-in-close-up-but-anti-senescence-in-long-shot
#8
Yoojin Kwon, Ji Wook Kim, Jo Ae Jeoung, Mi-Sung Kim, Chanhee Kang
When mammalian cells and animals face a variety of internal or external stresses, they need to make homeostatic changes so as to cope with various stresses. To this end, mammalian cells are equipped with two critical stress responses, autophagy and cellular senescence. Autophagy and cellular senescence share a number of stimuli including telomere shortening, DNA damage, oncogenic stress and oxidative stress, suggesting their intimate relationship. Autophagy is originally thought to suppress cellular senescence by removing damaged macromolecules or organelles, yet recent studies also indicated that autophagy promotes cellular senescence by facilitating the synthesis of senescence-associated secretory proteins...
September 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28922073/the-effects-of-individual-and-network-level-factors-on-discussion-of-cancer-experiences-survivors-of-childhood-cancer-in-korea
#9
Min Ah Kim, Jaehee Yi, Kort C Prince, Elizabeth Nagelhout, Yelena Wu
This study aimed to identify young adult Korean cancer survivors' individual- (psychological distress, stigma, sociodemographic variables, and cancer-related variables) and network-level factors (relationship type, social support type) that influence discussion of their cancer experiences. Sixty-eight survivors of childhood cancer who were recruited using snowball sampling nominated 245 individuals from their networks, including family and intimate partners (40%) and friends and acquaintances (60%), as people with whom they most frequently interacted...
September 18, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28914730/family-and-environmental-influences-on-child-behavioral-health-the-role-of-neighborhood-disorder-and-adverse-childhood-experiences
#10
Xiafei Wang, Kathryn Maguire-Jack
OBJECTIVE: The Adverse Childhood Experiences study suggests childhood adversity is a "root" origin for health and human development. Newer research is examining the more immediate impact of adverse childhood experiences (ACEs) on child development and the impact of neighborhood environment on the likelihood of and prevention ACEs. The extent to which all of these aspects of the child context fit together remains unclear. The current study seeks to fill this gap examining the precursors for ACEs and the multitude of ways in which a child's home life can impact his or her development...
September 7, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28903719/social-support-in-intimate-relationships-the-role-of-relationship-autonomy
#11
Brian P Don, Matthew D Hammond
Prior research on effective support interactions in intimate relationships often focuses on support provision rather than how people seek support. The current study investigated how differences in relationship autonomy-authentic and self-determined relationship motivations-predicted the behavior and outcomes of couples ( N = 80) in support interactions. Results indicated that support seekers' motivation and behavior were the primary contributor to effective support interactions. Support seekers who were autonomously motivated tended to seek support in a more direct and positive manner, which in turn promoted greater levels of emotional, informational, and tangible support from their partners...
August 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/28902264/intimate-partner-violence-as-a-predictor-of-antenatal-care-service-utilization-in-honduras
#12
Anne K Sebert Kuhlmann, Janine Foggia, Qiang Fu, Manuel Sierra
Objective: To describe the relationship between exposure to physical and/or sexual intimate partner violence (IPV) and indicators of antenatal care (ANC) service utilization among Honduran women of reproductive age. Methods: Data from the 2011-2012 Honduras Demographic and Health Survey were analyzed to describe the relationship between self-reported exposure to IPV and two ANC outcomes: (1) sufficient ANC visits (defined by the Honduran Ministry of Health as five or more visits) and (2) early ANC initiation (within the first trimester)...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28894996/the-relationship-between-parents-intimate-partner-victimization-and-youths-adolescent-relationship-abuse
#13
Weiwei Liu, Elizabeth A Mumford, Bruce G Taylor
Witnessing inter-parental intimate partner violence has been found to be associated with adolescents' own relationship abuse. This study investigates the relationship between patterns of inter-parental intimate partner verbal and physical violence victimization reported by parents and their children's reports of dating abuse experiences and behavior. Latent class analysis was performed on a sample of 610 parents (42% male and 67% white) and their dating adolescent children (ages 12-21 years; 52% male). Parents reported five types of victimization by their partners in the past year, while youth concurrently reported their own victimization and perpetration within their dating relationships...
September 12, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28894000/disassembly-of-the-staphylococcus-aureus-hibernating-100s-ribosome-by-an-evolutionarily-conserved-gtpase
#14
Arnab Basu, Mee-Ngan F Yap
The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesis, translational repression, starvation responses, and ribosome turnover. In the opportunistic pathogen Staphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) homodimerizes the 70S ribosomes to form a translationally silent 100S complex. Conversely, the 100S ribosomes dissociate into subunits and are presumably recycled for new rounds of translation. The regulation and disassembly of the 100S ribosome are largely unknown because the temporal abundance of the 100S ribosome varies considerably among different bacterial phyla...
September 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28889042/marginal-en-bloc-resection-of-c2-3-chordoma-with-bilateral-vertebral-artery-preservation-and-mesh-cage-reconstruction-with-review-of-previously-published-cases
#15
Steven O Tenny, Landon D Ehlers, J Will Robbins, Christopher C Gillis
BACKGROUND: Chordomas arise from remnants of the notocord and occur throughout the neuroaxis. En bloc resection of chordomas can prove especially challenging in the upper cervical spine secondary to the unique structural anatomy and intimate relationship to the vertebral arteries and spinal cord. CASE DESCRIPTION: We describe the resection of a C2-3 chordoma in a 55 year old female in two stage fashion with preservation of the vertebral arteries. First a posterior instrumented fusion and removal of the posterior elements was performed, followed by an anterior transmandibular en bloc resection with cage reconstruction with kick-plate support achievable with off-the-shelf products...
September 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28888281/intergenerational-relations-before-and-after-offspring-arrive-a-within-person-investigation
#16
Antti O Tanskanen
The birth of a child may re-orientate the relations between adult children and their parents; however, the previous studies on the topic are both scarce and methodologically limited. The current study investigates whether younger adults' entry into parenthood (i.e., the birth of the first child) is associated with increased contact frequency, emotional closeness, intimacy and conflict with their own parents. The participants are from the German Panel Analysis of Intimate Relationships and Family Dynamics, which is a prospective survey of younger adults with six annual follow-up waves between 2009 and 2014 (n = 17,662 person-observations from 4821 persons)...
September 2017: Social Science Research
https://www.readbyqxmd.com/read/28887888/neurocognitive-impairment-addressing-couple-and-family-challenges
#17
John S Rolland
Conditions involving neurocognitive impairment pose enormous challenges to couples and families. However, research and practice tend to focus narrowly on immediate issues for individual caregivers and their dyadic relationship with the affected member. A broad family systems approach with attention to family processes over time is needed in training, practice, and research. In this paper, Rolland's Family Systems Illness model provides a guiding framework to consider the interaction of different psychosocial types of neurocognitive conditions and their evolution over time with individual, couple, and family life-course development...
September 9, 2017: Family Process
https://www.readbyqxmd.com/read/28884268/can-a-parenting-intervention-to-prevent-early-conduct-problems-interrupt-girls-risk-for-intimate-partner-violence-10%C3%A2-years-later
#18
Miriam K Ehrensaft, Heather Knous Westfall, Phyllis Holditch Niolon, Thailyn Lopez, Dimitra Kamboukos, Keng-Yen Huang, Laurie Miller Brotman
This study tests whether a parenting intervention for families of preschoolers at risk for conduct problems can prevent later risk for intimate partner violence (IPV). Ninety-nine preschoolers at familial risk for conduct problems were randomly assigned to intervention or control conditions. Ten years later, 45 preschoolers and 43 of their siblings completed an assessment of their romantic relationships, including measures of physical and psychological IPV. The study focuses on the 54 females, including targets (n = 27) and siblings (n = 27) who participated in a 10-year follow-up (M age = 16...
September 7, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28880104/intimate-relationships-individual-adjustment-and-coronary-heart-disease-implications-of-overlapping-associations-in-psychosocial-risk
#19
Timothy W Smith, Brian R W Baucom
Being married or involved in a similar intimate relationship is associated with reduced risk of coronary heart disease (CHD). However, the quality of these relationships matters, as strain and disruption are associated with increased risk. These effects are typically studied separately from well-established psychosocial factors for CHD that are aspects of personality and emotional adjustment, even though discord and disruption in intimate relationships are related to these same individual characteristics. Thus, research to date tends to parse correlated risks, often taking a piecemeal approach by focusing on intimate relationships without considering aspects of personality and emotional adjustment that contribute to risk and protection, or focusing on individual-level risks while largely ignoring closely related health-relevant relationships...
September 2017: American Psychologist
https://www.readbyqxmd.com/read/28873087/women-s-and-men-s-reports-of-past-year-prevalence-of-intimate-partner-violence-and-rape-and-women-s-risk-factors-for-intimate-partner-violence-a-multicountry-cross-sectional-study-in-asia-and-the-pacific
#20
Rachel Jewkes, Emma Fulu, Ruchira Tabassam Naved, Esnat Chirwa, Kristin Dunkle, Regine Haardörfer, Claudia Garcia-Moreno
BACKGROUND: Understanding the past-year prevalence of male-perpetrated intimate partner violence (IPV) and risk factors is essential for building evidence-based prevention and monitoring progress to Sustainable Development Goal (SDG) 5.2, but so far, population-based research on this remains very limited. The objective of this study is to compare the population prevalence rates of past-year male-perpetrated IPV and nonpartner rape from women's and men's reports across 4 countries in Asia and the Pacific...
September 2017: PLoS Medicine
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