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https://www.readbyqxmd.com/read/29343719/the-significant-role-of-c-abl-kinase-in-barrier-altering-agonists-mediated-cytoskeletal-biomechanics
#1
X Wang, L Wang, J G N Garcia, S M Dudek, G S Shekhawat, V P Dravid
Exploration of human pulmonary artery endothelial cell (EC) as a prototypical biomechanical system has important pathophysiologic relevance because this cell type plays a key role in the development of a wide variety of clinical conditions. The complex hierarchical organization ranging from the molecular scale up to the cellular level has an intimate and intricate relationship to the barrier function between lung tissue and blood. To understand the innate molecule-cell-tissue relationship across varied length-scales, the functional role of c-Abl kinase in the cytoskeletal nano-biomechanics of ECs in response to barrier-altering agonists was investigated using atomic force microscopy...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340442/-psychological-violence-against-women-what-factors-increase-the-risk-of-this-kind-of-intimate-partner-abuse
#2
Ana Safranoff
Using data from Argentina's National Study on Violence Against Women [Estudio nacional sobre violencias contra las mujeres] carried out in 2015, the article identifies the risk factors that increase women's vulnerability to psychological abuse. Findings show that women who are more prone to be victims of this kind of partner violence are those who are less educated, older, do not earn a wage for their work, live with children at home, are involved in less "formal" long-term relationships, as well as those whose male partners have a lower educational level than their own and/or have alcohol problems and/or were victims or witnesses of violence during their childhood...
October 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29333730/day-to-day-mastery-and-self-efficacy-changes-during-a-smoking-quit-attempt-two-studies
#3
Lisa M Warner, Gertraud Stadler, Janina Lüscher, Nina Knoll, Sibylle Ochsner, Rainer Hornung, Urte Scholz
OBJECTIVE: In social-cognitive theory, it is hypothesized that mastery experiences (successfully implementing behaviour change) are a source of self-efficacy, and self-efficacy increases the opportunity for experiencing mastery. Vicarious experiences (seeing others succeed) are suggested as another source of self-efficacy. However, the hypothesis of this reciprocal relationship has not been tested using a day-to-day design. DESIGN: This article reports findings from two intensive longitudinal studies, testing the reciprocal relationship of self-efficacy and its two main sources within the naturally occurring process of quitting smoking (without intervention)...
January 15, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29332548/sociodemographic-and-incident-variables-as-predictors-of-victim-injury-from-intimate-partner-violence-findings-from-police-reports
#4
Marie E Karlsson, Kathryn Reid Quiñones, Cristina M López, Arthur R Andrews, Megan M Wallace, Alyssa Rheingold
Predictors of victim injury from intimate partner violence (IPV) were investigated using 1,292 police reports collected in South Carolina in 2009/2010. All cases were opposite sex adults. Results from bivariate statistics showed that IPV cases with ( n = 649) and without visible injuries ( n = 643) differed on victim gender, victim race, type of relationship, and perpetrator's alcohol use. Results from a logistic regression analysis predicting victim injury showed higher odds ratios for males, Whites, and couples identified as cohabitants...
November 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332513/the-meaning-of-choosing-a-spouse-among-ultra-orthodox-jewish-women-who-found-themselves-in-a-violent-relationship
#5
Tova Band-Winterstein, Ilanit Tuito
This research note addresses how ultra-Orthodox Jewish women in Israel coping with intimate partner violence experienced the spouse selection process. In-depth semistructured qualitative-phenomenological interviews were conducted with 17 women. Four major themes emerged: (a) "The matchmaker seemingly fell asleep on her watch"; (b) The parents' mistakes; (c) "The rabbi told me to jump into the water. Now he should hand me the paddles to get out!" The rabbi's role; and (d) "That's it . . . I follow it blindly": The system...
August 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332508/battered-wives-or-dependent-mothers-negotiating-familial-ideology-in-law
#6
Chulani Kodikara
More than a decade after its passing, Sri Lanka's Prevention of Domestic Violence Act (PDVA) remains a remedy of last resort for female survivors of intimate partner violence, as there is little support to take on a rights-defined identity as a battered woman both inside and outside the courtroom. However, large numbers of women are accessing the Maintenance Act of 1999 to exit violent relationships without the censure and stigma that attaches to the PDVA. The key to understanding this phenomenon is to consider how familial ideology works in unpredictable ways within the Sri Lankan judicial system...
September 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29332491/relationship-a-symmetries-and-violence-comparing-intimates-and-nonpartners
#7
Elizabeth Griffiths, Carolyn Yule, Rosemary Gartner
Violence between social equals differs in character from violence between persons in asymmetrical relationships. Specifically, issues of contention motivating violence vary by the relative status of opponents, such that violence over symbolic issues is more common between symmetrical than asymmetrical opponents. Recent studies have substantiated these predictions in nonpartner relationships. Using data from interviews of incarcerated women, this study explores how intimate partner violence compares with violence between nonpartner opponents...
June 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29330733/intergenerational-continuity-in-depression-the-importance-of-time-varying-effects-maternal-co-morbid-health-risk-behaviors-and-child-s-gender
#8
Megan Bears Augustyn, Celia J Fulco, Kimberly L Henry
Intergenerational continuity in depressive symptoms is well established between mother and child, but there are still important facets of this relationship that are underexplored. We examine intergenerational continuity in depressive symptoms between mother-child dyads as a flexible function of child age and account for the potential moderating role of maternal co-morbid health risk behaviors. Using prospective, self-report data collected yearly from 413 mother-child dyads (210 mother-son dyads and 203 mother-daughter dyads) between child ages 12-17, the results indicate that the effect of maternal depressive symptoms on daughters' depressive symptoms steadily increases throughout adolescence whereas the effect of maternal depressive symptoms on sons' depressive symptoms is relatively small, stable, and non-significant during mid-adolescence before increasing in effect in later adolescence...
January 12, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29327315/maternal-bonding-behavior-adult-intimate-relationship-and-quality-of-life
#9
Michaela Schmoeger, Matthias Deckert, Petra Wagner, Ulrike Sirsch, Ulrike Willinger
Continuity and discontinuity in the development of social relationships have been investigated by reviewing the course of social bonds and by analyzing the effects of a sound intimate relationship in adulthood in conjunction with recalled maternal bonding on the quality of life among students.A questionnaire-based study of 207 students was conducted. Perceptions of maternal bonding were designated as being representative of one of the two contrasting bonding types "optimal maternal bonding" and "affectionless maternal control" assessed by the Parental Bonding Instrument (PBI) and combined with perceptions of a sound intimate adult relationship measured by the Family Assessment Measure III Dyadic Relationships Scale (FAM-III-D)...
January 11, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29326196/young-adults-perspectives-on-living-with-kidney-failure-a-systematic-review-and-thematic-synthesis-of-qualitative-studies
#10
Phillippa K Bailey, Alexander J Hamilton, Rhian L Clissold, Carol D Inward, Fergus J Caskey, Yoav Ben-Shlomo, Amanda Owen-Smith
INTRODUCTION: Young adults fare worse than younger adolescents or older adults on a broad range of health indicators. Those with a chronic illness such as renal failure are a particularly vulnerable group, who experience poor outcomes compared with both children and older adults. Understanding how being in receipt of renal replacement therapy (RRT) affects the lives of young adults might help us to better prepare and support these individuals for and on RRT, and improve outcomes. This study aimed to synthesise research describing young adults' experiences of the psychosocial impact of kidney failure and RRT...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29325549/does-exposure-to-interparental-violence-increase-women-s-risk-of-intimate-partner-violence-evidence-from-nigeria-demographic-and-health-survey
#11
Bola Lukman Solanke
BACKGROUND: Exposure to interparental violence (EIPV) has been identified as a risk factor for intimate partner violence (IPV). However, studies in Nigeria have rarely and specifically examined exposure to interparental violence as a predictor of IPV. The objective of the study was to examine the relationship between exposure to interparental violence and women's experience of intimate partner violence. METHODS: The 2013 Nigeria Demographic and Health Survey (NDHS) women recode dataset was analysed...
January 11, 2018: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/29325505/the-relationship-between-cholesterol-level-and-alzheimer-s-disease-associated-app-proteolysis-a%C3%AE-metabolism
#12
Chaoqun Wang, Yikai Shou, Jie Pan, Yue Du, Cuiqing Liu, Huanhuan Wang
Globally, Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population, the hallmark of which is amyloid β (Aβ) peptide. Energy metabolism and AD pathogenesis are believed to influence one another. Different cholesterol levels are thought to influence various steps in neurotoxic Aβ generation, including amyloid precursor protein (APP) proteolysis and the corresponding activities of α-, β-, and γ-secretases. In addition, cholesterol has been proved to mediate Aβ metabolism, such as its fibrillation, transportation, degradation, and clearance processes...
January 11, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29322332/evaluation-of-age-dependent-morphometrics-of-the-meniscofemoral-ligaments-in-reference-to-the-posterior-cruciate-ligament-in-routine-mri
#13
Sebastian Röhrich, Franz Kainberger, Lena Hirtler
OBJECTIVES: To quantify the morphological correlation between the posterior cruciate ligament (PCL) and the meniscofemoral ligaments (MFLs), to propose normal ranges for different age populations, and to define guidelines for correct identification and differentiation of MFLs in routine MRI. METHODS: Three hundred forty-two subjects were included retrospectively and subdivided into five age groups. Morphometrics of the PCL and the MFLs were measured on standard MRI in the sagittal, coronal, and axial planes...
January 10, 2018: European Radiology
https://www.readbyqxmd.com/read/29321125/efficacy-of-a-web-based-safety-decision-aid-for-women-experiencing-intimate-partner-violence-randomized-controlled-trial
#14
Jane Koziol-McLain, Alain C Vandal, Denise Wilson, Shyamala Nada-Raja, Terry Dobbs, Christine McLean, Rose Sisk, Karen B Eden, Nancy E Glass
BACKGROUND: Intimate partner violence (IPV) is a human rights violation and leading health burden for women. Safety planning is a hallmark of specialist family violence intervention, yet only a small proportion of women access formal services. A Web-based safety decision aid may reach a wide audience of women experiencing IPV and offer the opportunity to prioritize and plan for safety for themselves and their families. OBJECTIVE: The aim of this study was to test the efficacy of a Web-based safety decision aid (isafe) for women experiencing IPV...
January 10, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29320383/the-mask-of-happiness-unmasking-coercive-control-in-intimate-relationships
#15
Nicole Schneider
While most mental health professionals know how to recognize the obvious and most concerning presentations of possible intimate partner violence, there are numerous ways in which a partner may be controlled, bullied, isolated, exploited, and manipulated that do not present such observable signs. The literature pertaining to domestic abuse has increasingly moved away from injury as a necessary marker and instead has begun to highlight the importance of more covert but similarly deleterious processes within certain intimate relationships...
January 2018: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29319844/gender-differences-in-intimate-conflict-initiation-and-escalation-tendencies
#16
Zeev Winstok, Ronit Smadar-Dror, Michael Weinberg
According to gender motivation theory, men are driven by a desire to enhance their status; whereas, women are motivated by a desire to reduce risk, and the behavioral expressions of those motivations are context-dependent. In order to test this theory in the context of intimate relationships, this study compared men's and women's escalatory tendencies in the initial development of intimate conflict. These tendencies were conceptualized in terms of four attributes: two attributes that represent response intention (decision and style) and two others that represent motivations for that intention (putting one's partner in his or her place and avoiding conflict)...
January 10, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29314492/the-binding-mode-of-a-repeat-like-tau-sequence-with-tubulin
#17
Harindranath Kadavath, Yunior Cabrales Fontela, Mariusz Jaremko, Lukasz Jaremko, Kerstin Overkamp, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstetter
The microtubule-associated protein Tau promotes the polymerization of tubulin and modulates the function of microtubules. Because of the dynamic nature of the Tau/tubulin interaction, the structural basis of this complex has remained largely elusive. Using a combination of NMR methods optimized for ligand-receptor interactions and site-directed mutagenesis we demonstrate that the flanking domain downstream of the four microtubule-binding repeats of Tau binds competitively to a site on the α-tubulin surface...
January 3, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29311715/the-bone-marrow-niche-in-mds-and-mgus-implications-for-aml-and-mm
#18
REVIEW
Irene M Ghobrial, Alexandre Detappe, Kenneth C Anderson, David P Steensma
Several haematological malignancies, including multiple myeloma (MM) and acute myeloid leukaemia (AML), have well-defined precursor states that precede the development of overt cancer. MM is almost always preceded by monoclonal gammopathy of undetermined significance (MGUS), and at least a quarter of all patients with myelodysplastic syndromes (MDS) have disease that evolves into AML. In turn, MDS are frequently anteceded by clonal haematopoiesis of indeterminate potential (CHIP). The acquisition of additional genetic and epigenetic alterations over time clearly influences the increasingly unstable and aggressive behaviour of neoplastic haematopoietic clones; however, perturbations in the bone-marrow microenvironment are increasingly recognized to have key roles in initiating and supporting oncogenesis...
January 9, 2018: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/29311621/high-temperature-limit-of-photosynthetic-excitons
#19
Margus Rätsep, Renata Muru, Arvi Freiberg
Excitons in light-harvesting complexes are known to significantly improve solar-energy harnessing. Here we demonstrate photosynthetic excitons at super-physiological temperatures reaching 60-80 °C in different species of mesophilic photosynthetic bacteria. It is shown that the survival of light-harvesting excitons in the peripheral LH2 antennae is restricted by thermal decomposition of the pigment-protein complex rather than by any intrinsic property of excitons. The regular spatial organization of the bacteriochlorophyll a pigments supporting excitons in this complex is lost upon the temperature-induced breakdown of its tertiary structure...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29309251/women-interact-more-comfortably-and-intimately-with-gay-men-but-not-straight-men-after-learning-their-sexual-orientation
#20
Eric M Russell, William Ickes, Vivian P Ta
Research suggests that the development of close, opposite-sex friendships is frequently impeded by men's often one-sided sexual attraction to women. But what if this element were removed? The current research tested the hypothesis that women engage in more comfortable and intimate interactions with a gay (but not a straight) man immediately after discovering his sexual orientation. In two studies, female participants engaged in imagined or actual initial interactions with either a straight man or a gay man...
January 1, 2018: Psychological Science
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