keyword
MENU ▼
Read by QxMD icon Read
search

childhood cancer outcomes

keyword
https://www.readbyqxmd.com/read/29143289/agents-in-development-for-childhood-acute-lymphoblastic-leukemia
#1
REVIEW
Kelly W Maloney, Lia Gore
Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. Standard chemotherapy has afforded outstanding outcomes for many patients; however, there remain some sub-groups with high-risk features, refractory disease, and patients that  relapse who have a poor prognosis with conventional treatments. Over the past decade, there have been significant advances in newer treatment options, including improved monoclonal antibody therapies, T cell engagers, and chimeric antigen T-cell receptor products, all of which have changed the landscape for patients who relapse...
November 15, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/29130290/parent-patient-and-health-professional-perspectives-regarding-enteral-nutrition-in-paediatric-oncology
#2
Jennifer Cohen, Claire E Wakefield, Linda C Tapsell, Karen Walton, Richard J Cohn
AIM: Enteral tube feeding (ETF) is an important part of treatment for paediatric cancer patients. Without nutritional therapy, the prevalence of under-nutrition during treatment for childhood cancer may be as high as 50%. To ensure that the appropriate initiation of ETF is optimised, information on the views of key stakeholders regarding ETF is needed. METHODS: In total, 48 interviews were conducted with parents of paediatric cancer patients (n = 20), patients (n = 10) and members of the paediatric oncology health-care team (n = 18)...
November 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29126510/long-term-outcomes-of-pediatric-inflammatory-bowel-disease
#3
Soheila Nasiri, Mary Ellen Kuenzig, Eric I Benchimol
The incidence and prevalence of childhood-onset inflammatory bowel diseases (IBD), including subtypes Crohn's disease and ulcerative colitis, have risen dramatically in recent years, and have emerged globally as important pediatric chronic diseases. Therefore, health care providers are more frequently encountering very young children with IBD, a chronic and incurable condition requiring life-long therapy. These children are living long lives with IBD and therefore knowledge of long-term outcomes is increasingly important to better counsel families and determine the best course of treatment...
December 2017: Seminars in Pediatric Surgery
https://www.readbyqxmd.com/read/29124416/prevalence-and-correlates-of-health-information-seeking-among-hispanic-and-non-hispanic-childhood-cancer-survivors
#4
Kimberly A Miller, Cynthia N Ramirez, Katherine Y Wojcik, Anamara Ritt-Olson, Lourdes Baezconde-Garbanati, Stefanie M Thomas, David R Freyer, Ann S Hamilton, Joel E Milam
PURPOSE: Childhood cancer survivors (CCS) report high unmet information needs. This study examined the prevalence of cancer-related information-seeking among CCS and investigated associations between information-seeking behavior and positive health outcomes such as follow-up care. METHODS: Participants (n = 193) were young adult CCS diagnosed with cancer in Los Angeles County, 54% of Hispanic ethnicity, with a mean age of 19.87, in remission, and at least 2 years from completion of treatment...
November 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29121606/pattern-of-hematological-malignancies-in-adolescents-and-young-adults-in-bangladesh
#5
Md Mahbub Hasan, Enayetur Raheem, Tanvira Afroze Sultana, Mohammad Sorowar Hossain
INTRODUCTION: The adolescent and young adult (AYA) age group (15-39 years) bears distinct characteristics in terms of cancer biology, long-term health and treatment-related complications and psychosocial aspects. The overall scenario of cancer including hematological malignancies (HMs) is largely unknown in Bangladesh, where a significant proportion of people (44% of total population) belong to AYA age group. This study aims to describe the patterns of HM among AYA in the context of Bangladesh METHODS: Two previously published datasets (on hematological malignancies and childhood and adolescent cancer) were merged to construct a comprehensive dataset focusing exclusively on HMs in AYA age group...
November 6, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29117847/the-impact-of-school-visits-on-siblings-of-children-with-cancer
#6
Isabelle Sjoberg, Jason D Pole, Marilyn Cassidy, Claudette Boilard, Sharon Costantini, Donna L Johnston
BACKGROUND: Childhood cancer affects the entire family. Siblings experience similar stress to that of the ill child, including anger, depression, jealousy, guilt, and social isolation. School reentry programs are shown to be positive interventions for patients, it is hypothesized that similar outcomes exist for siblings. OBJECTIVE: To examine the feasibility of studying the impact of the Ontario Oncology Nurse School Visitation Program on the well-being and school adjustment of siblings of pediatric cancer patients...
November 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29115964/the-matex-cohort-a-finnish-population-register-birth-cohort-to-study-health-effects-of-prenatal-exposures
#7
Isabell K Rumrich, Kirsi Vähäkangas, Matti Viluksela, Mika Gissler, Heljä-Marja Surcel, Hanna de Ruyter, Jukka Jokinen, Otto Hänninen
BACKGROUND: The prevalence of chronic diseases, such as immune, neurobehavioral, and metabolic disorders has increased in recent decades. According to the concept of Developmental Origin of Health and Disease (DOHaD), developmental factors associated with environmental exposures and maternal lifestyle choices may partly explain the observed increase. Register-based epidemiology is a prime tool to investigate the effects of prenatal exposures over the whole life course. Our aim is to establish a Finnish register-based birth cohort, which can be used to investigate various (prenatal) exposures and their effects during the whole life course with first analyses focusing on maternal smoking and air pollution...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29108844/liver-transplantation-for-primary-hepatic-malignancies-of-childhood-the-unos-experience
#8
Emma C Hamilton, Julius Balogh, Duc T Nguyen, Edward A Graviss, Andras A Heczey, Mary T Austin
BACKGROUND/PURPOSE: The purpose of this study was to determine factors associated with patient and graft survival following orthotopic liver transplantation (OLT) in children and adolescents with primary hepatic malignancies. METHODS: The United Network for Organ Sharing (UNOS) database was queried for all patients <18years old who received an OLT with a primary malignant liver tumor between 1987 and 2012 (n=544). Five-year patient and graft survival were determined using Kaplan-Meier methodology, and independent predictors of survival were determined using multivariate Cox proportional hazards model...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29106578/cancer-risk-in-children-born-after-donor-art
#9
C L Williams, K J Bunch, M F G Murphy, C A Stiller, B J Botting, W H Wallace, M C Davies, A G Sutcliffe
STUDY QUESTION: Do children born after donor ART have an increased risk of developing childhood cancer in comparison to the general population? SUMMARY ANSWER: This study showed no overall increased risk of childhood cancer in individuals born after donor ART. WHAT IS KNOWN ALREADY: Most large population-based studies have shown no increase in overall childhood cancer incidence after non-donor ART; however, other studies have suggested small increased risks in specific cancer types, including haematological cancers...
November 2, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29095680/prediction-of-ischemic-heart-disease-and-stroke-in-survivors-of-childhood-cancer
#10
Eric J Chow, Yan Chen, Melissa M Hudson, Elizabeth A M Feijen, Leontien C Kremer, William L Border, Daniel M Green, Lillian R Meacham, Daniel A Mulrooney, Kirsten K Ness, Kevin C Oeffinger, Cécile M Ronckers, Charles A Sklar, Marilyn Stovall, Helena J van der Pal, Irma W E M van Dijk, Flora E van Leeuwen, Rita E Weathers, Leslie L Robison, Gregory T Armstrong, Yutaka Yasui
Purpose We aimed to predict individual risk of ischemic heart disease and stroke in 5-year survivors of childhood cancer. Patients and Methods Participants in the Childhood Cancer Survivor Study (CCSS; n = 13,060) were observed through age 50 years for the development of ischemic heart disease and stroke. Siblings (n = 4,023) established the baseline population risk. Piecewise exponential models with backward selection estimated the relationships between potential predictors and each outcome. The St Jude Lifetime Cohort Study (n = 1,842) and the Emma Children's Hospital cohort (n = 1,362) were used to validate the CCSS models...
November 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29095311/the-relationship-between-iron-bone-marrow-stores-and-response-to-treatment-in-pediatric-acute-lymphoblastic-leukemia
#11
Alireza Moafi, Mozhdeh Ziaie, Marjan Abedi, Soheila Rahgozar, Nahid Reisi, Pardis Nematollahi, Hadi Moafi
Iron is an intracellular element whose accumulation in the body is associated with tissue damage. This study examines the effect of iron on pediatric acute lymphoblastic leukemia (ALL) and its "response to treatment." At the end of the first year of treatment, bone marrow iron store (BMIS) was evaluated in children with ALL and the relationship between iron store and minimal residual disease was investigated. Moreover, the 3-year disease-free survival (3-DFS) of patients was determined. Patients' BMIS were compared with that of subjects with normal bone marrow...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29067473/the-dawn-of-immune-revolution-in-children-early-experiences-with-checkpoint-inhibitors-in-childhood-malignancies
#12
REVIEW
Maurizio Lucchesi, Iacopo Sardi, Gianfranco Puppo, Antonio Chella, Claudio Favre
Modern immunotherapy with checkpoint inhibitors has changed clinical practice of adult patients with advanced cancer. Blockade of CTLA-4 and PD-1 pathways have shown survival benefits in different diseases. In children, combination of surgery, radiotherapy and chemotherapy have improved survival rates of solid tumors. However, the outcomes for subsets of patients such as those with high-grade, refractory, or metastatic disease remain extremely poor. Currently, the treatment of these patients is almost exclusively based on standard chemotherapy...
October 24, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29065109/risk-stratification-of-childhood-cancer-survivors-necessary-for-evidence-based-clinical-long-term-follow-up
#13
Clare Frobisher, Adam Glaser, Gill A Levitt, David J Cutter, David L Winter, Emma R Lancashire, Kevin C Oeffinger, Joyeeta Guha, Julie Kelly, Raoul C Reulen, Michael M Hawkins
BACKGROUND: Reorganisation of clinical follow-up care in England was proposed by the National Cancer Survivorship Initiative (NCSI), based on cancer type and treatment, ranging from Level 1 (supported self-management) to Level 3 (consultant-led care). The objective of this study was to provide an investigation of the risks of serious adverse health-outcomes associated with NCSI Levels of clinical care using a large population-based cohort of childhood cancer survivors. METHODS: The British Childhood Cancer Survivor Study (BCCSS) was used to investigate risks of specific causes of death, subsequent primary neoplasms (SPNs) and non-fatal non-neoplastic outcomes by NCSI Level...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29061788/expression-of-truncated-neurokinin-1-receptor-in-childhood-neuroblastoma-is-independent-of-tumor-biology-and-stage
#14
Alexandra Pohl, Roland Kappler, Jakob Mühling, Dietrich VON Schweinitz, Michael Berger
BACKGROUND: Neuroblastoma is an embryonal malignancy arising from the aberrant growth of neural crest progenitor cells of the sympathetic nervous system. The tachykinin receptor 1 (TACR1) - substance P complex is associated with tumoral angiogenesis and cell proliferation in a variety of cancer types. Inhibition of TACR1 was recently described to impede growth of NB cell lines. However, the relevance of TACR1 in clinical settings is unknown. PATIENTS AND METHODS: We investigated gene expression levels of full-length and truncated TACR1 in 59 neuroblastomas and correlated these data with the patients' clinical parameters such as outcome, metastasis, International Neuroblastoma Staging System (INSS) status, MYCN proto-oncogene, bHLH transcription factor (MYCN) status, gender and age...
November 2017: Anticancer Research
https://www.readbyqxmd.com/read/29046041/development-and-content-validation-of-the-transition-readiness-inventory-item-pool-for-adolescent-and-young-adult-survivors-of-childhood-cancer
#15
Lisa A Schwartz, Jessica L Hamilton, Lauren D Brumley, Lamia P Barakat, Janet A Deatrick, Dava E Szalda, Katherine B Bevans, Carole A Tucker, Lauren C Daniel, Eliana Butler, Anne E Kazak, Wendy L Hobbie, Jill P Ginsberg, Alexandra M Psihogios, Elizabeth Ver Hoeve, Lisa K Tuchman
Objective: The development of the Transition Readiness Inventory (TRI) item pool for adolescent and young adult childhood cancer survivors is described, aiming to both advance transition research and provide an example of the application of NIH Patient Reported Outcomes Information System methods. Methods: Using rigorous measurement development methods including mixed methods, patient and parent versions of the TRI item pool were created based on the Social-ecological Model of Adolescent and young adult Readiness for Transition (SMART)...
October 1, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29024558/overweight-obesity-and-adiposity-in-survivors-of-childhood-brain-tumours-a-systematic-review-and-meta-analysis
#16
REVIEW
K-W Wang, A Fleming, D L Johnston, S M Zelcer, S R Rassekh, S Ladhani, A Socha, J Shinuda, S Jaber, S Burrow, S K Singh, L Banfield, R J de Souza, L Thabane, M C Samaan
Survivors of childhood brain tumours (SCBT) have increased cardiometabolic risks, but the determinants of these risks are unclear. This systematic review aims to compare the prevalence of overweight and obesity as well as adiposity measures between SCBT and non-cancer controls. The PubMed, EMBASE, MEDLINE, CINAHL and the Cochrane Library databases were searched. The primary outcomes were the prevalence of overweight and obesity based on body mass index. The secondary outcomes were adiposity measures including percent fat mass, waist-to-hip and waist-to-height ratios...
October 11, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29023764/liver-diseases-in-adult-life-after-childhood-cancer-in-scandinavia-aliccs-a-population-based-cohort-study-of-32-839-one-year-survivors
#17
Trine Gade Bonnesen, Jeanette F Winther, Klaus K Andersen, Peter H Asdahl, Sofie de Fine Licht, Thorgerdur Gudmundsdottir, Anna Sällfors Holmqvist, Laura-Maria Madanat-Harjuoja, Laufey Tryggvadottir, Finn Wesenberg, Carsten Heilmann, Jørgen H Olsen, Henrik Hasle
Information on late onset liver complications after childhood cancer is scarce. To ensure an appropriate follow-up of childhood cancer survivors and reducing late liver complications, the need for comprehensive and accurate information is presented. We evaluate the risk of liver diseases in a large childhood cancer survivor cohort. We included all one-year survivors of childhood cancer treated in the five Nordic countries. A Cox proportional hazards model was used to estimate hospitalisation rate (hazard) ratios (HRs) for each liver outcome according to type of cancer...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28992218/long-term-consequences-of-renal-insufficiency-in-children-lessons-learned-from-the-dutch-leric-study
#18
Jaap W Groothoff, Martin Offringa, Martha Grootenhuis, Kitty J Jager
Few data exist on the prospects in adulthood for children on chronic renal replacement therapy (RRT). This article summarizes the results of a comprehensive Dutch long-term follow-up study performed in 2000 and 2010 of patients with RRT onset at age <15 years between 1972 and 1992. After a median of 25.5 RRT years, patients had stayed 23% of RRT time on dialysis. We observed a 30 times greater mortality risk compared with age-matched peers with cardiovascular disease (CVD) as the main cause of death during 1972-2000 and infections during 2000-10...
July 7, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28960781/whole-lung-irradiation-in-stage-iv-wilms-tumor-patients-thyroid-dosimetry-and-outcomes
#19
Tiffany M Morgan, Hasan Danish, Ronica H Nanda, Natia Esiashvili, Lillian R Meacham
PURPOSE: To report the thyroid dosimetry and long-term follow-up of childhood cancer survivors treated with whole lung irradiation (WLI) for Wilms tumor. METHODS: Twenty-eight patients with pulmonary metastases from Wilms tumor who underwent WLI from 2000 TO 2012 at a single institution were reviewed. Radiation dose to the thyroid gland in each case was calculated. Postradiation thyroid function test (TFT) results and management of thyroid function abnormalities were extracted from the medical records...
September 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28949788/care-at-end-of-life-influences-grief-a-nationwide-long-term-follow-up-among-young-adults-who-lost-a-brother-or-sister-to-childhood-cancer
#20
Malin Lövgren, Josefin Sveen, Tommy Nyberg, Alexandra Eilegård Wallin, Holly G Prigerson, Gunnar Steineck, Ulrika Kreicbergs
BACKGROUND: A majority of cancer-bereaved siblings report long-term unresolved grief, thus it is important to identify factors that may contribute to resolving their grief. OBJECTIVE: To identify modifiable or avoidable family and care-related factors associated with unresolved grief among siblings two to nine years post loss. DESIGN: This is a nationwide Swedish postal survey. MEASUREMENTS: Study-specific questions and the standardized instrument Hospital Anxiety and Depression Scale...
September 26, 2017: Journal of Palliative Medicine
keyword
keyword
21281
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"