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https://www.readbyqxmd.com/read/28919117/global-regional-and-national-incidence-prevalence-and-years-lived-with-disability-for-328-diseases-and-injuries-for-195-countries-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#1
(no author information available yet)
BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. METHODS: We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28917267/distance-delivered-physical-activity-interventions-for-childhood-cancer-survivors-a-systematic-review-and-meta-analysis
#2
REVIEW
David Mizrahi, Claire E Wakefield, Joanna E Fardell, Veronica F Quinn, Qishan Lim, Briana K Clifford, David Simar, Kirsten K Ness, Richard J Cohn
This review aimed to determine the feasibility of distance-delivered physical activity (PA) interventions in childhood cancer survivors (CCS), and assess the effect on PA levels, and physical, physiological and psychological outcomes. We searched electronic databases until May 2016, including studies following intensive treatment. Meta-analyses were conducted on randomized controlled trials. We calculated the effect of interventions on PA levels and physical, physiological and psychological health outcomes...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28915338/neurocognitive-psychosocial-and-quality-of-life-outcomes-in-adult-survivors-of-childhood-non-hodgkin-lymphoma
#3
Matthew J Ehrhardt, Daniel A Mulrooney, Chenghong Li, Malek J Baassiri, Kari Bjornard, John T Sandlund, Tara M Brinkman, I-Chan Huang, Deo Kumar Srivastava, Kirsten K Ness, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Children with non-Hodgkin lymphoma (NHL) undergo treatment with central nervous system-directed therapy, the potentially neurotoxic effects of which have not been reported in NHL survivors. METHODS: NHL survivors (n = 187) participating in the St. Jude Lifetime Cohort who were 10 or more years from their diagnosis and were 18 years old or older underwent neurocognitive, emotional distress (Brief Symptom Inventory 18), and health-related quality of life (HRQOL) assessments (36-Item Short Form Health Survey)...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28900876/improving-diagnostic-and-therapeutic-outcomes-in-pediatric-brain-tumors
#4
REVIEW
Sydney T Grob, Jean M Mulcahy Levy
Pediatric brain tumors are the primary cause of cancer-related death during childhood. Unfortunately, the number of primary and metastatic brain tumors is steadily increasing while the mortality rates for many central nervous system (CNS) lesions have remained stagnant. Molecularly defined tumor classes have been added to the most recent 2016 World Health Organization (WHO) Classification System of Central Nervous System Brain Tumors, driving potential new treatments and identifying targets to improve survival for these patients...
September 12, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28894229/vegf-expression-correlates-with-neuronal-differentiation-and-predicts-a-favorable-prognosis-in-patients-with-neuroblastoma
#5
Wen-Chin Weng, Kuan-Hung Lin, Pei-Yi Wu, Ya-Hsuan Ho, Yen-Lin Liu, Bo-Jeng Wang, Chien-Chin Chen, Yueh-Chien Lin, Yung-Feng Liao, Wang-Tso Lee, Wen-Ming Hsu, Hsinyu Lee
Neuroblastoma (NB) is a childhood cancer with a low survival rate and great metastatic potential. Vascular endothelial growth factor (VEGF), an angiogenesis factor, has been found to be involved in CRT-related neuronal differentiation of NB cells. In this study, we further confirmed the role VEGF in NB through mouse xenograft model and clinical analysis from NB patients. In xenograft experiments, CRT overexpression effectively inhibited the tumor growth. In addition, the mRNA and protein levels of VEGF and differentiation marker GAP-43 were upregulated by induced CRT expression...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888809/childhood-maltreatment-psychological-resources-and-depressive-symptoms-in-women-with-breast-cancer
#6
Kate Ryan Kuhlman, Chloe C Boyle, Michael R Irwin, Patricia A Ganz, Catherine M Crespi, Arash Asher, Laura Petersen, Julienne E Bower
Childhood maltreatment is associated with elevated risk for depression across the human lifespan. Identifying the pathways through which childhood maltreatment relates to depressive symptoms may elucidate intervention targets that have the potential to reduce the lifelong negative health sequelae of maltreatment exposure. In this cross-sectional study, 271 women with early-stage breast cancer were assessed after their diagnosis but before the start of adjuvant treatment (chemotherapy, radiation, endocrine therapy)...
September 7, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28887601/is-there-a-role-for-epithelial-mesenchymal-transition-in-adrenocortical-tumors
#7
Daniel Bulzico, Paulo Antônio Silvestre de Faria, Camila Bravo Maia, Marcela Pessoa de Paula, Davi Coe Torres, Gerson Moura Ferreira, Bruno Ricardo Barreto Pires, Rocio Hassan, Eliana Abdelhay, Mario Vaisman, Leonardo Vieira Neto
PURPOSE: Epithelial-mesenchymal transition (EMT) is a biological dynamic process by which epithelial cells lose their epithelial phenotype and acquire mesenchymal invasive and migratory characteristics. This has been postulated as an essential step during cancer progression and metastasis. Although this is well described in other tumors, the role of EMT in adrenocortical tumors (ACT) has yet to be addressed. METHODS: The aim of this study was to evaluate the expression of EMT markers e-cadherin, vimentin, and fibronectin, along with EMT-transcription factors (EMT-TFs), TWIST1, SIP1, and SNAIL in 24 adrenocortical carcinoma (ACC), 19 adrenocortical adenomas (ACA), 27 childhood-onset adrenocortical tumors (CAT), and 12 normal adrenal glands...
September 8, 2017: Endocrine
https://www.readbyqxmd.com/read/28859039/clinical-profile-and-outcome-of-influenza-a-h1n1-in-pediatric-oncology-patients-during-the-2015-outbreak-a-single-center-experience-from-northern-india
#8
Nishant Verma, Vishal Pooniya, Archana Kumar
BACKGROUND: Owing to their immunocompromised status, childhood cancer patients on chemotherapy are at a greater risk for Influenza infection and its associated complications. There is limited data available on the clinical profile and outcome of Influenza A/H1N1 in this subset of patients. METHODS: A retrospective study was performed of Influenza A/H1N1 cases diagnosed between January 2015 to December 2015 in the in-patients of Pediatric Oncology unit of a tertiary care hospital from Northern India...
August 30, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28853979/the-effect-of-atorvastatin-on-vascular-function-and-structure-in-young-adult-survivors-of-childhood-cancer-a-randomized-placebo-controlled-pilot-clinical-trial
#9
Kara L Marlatt, Julia Steinberger, Kyle D Rudser, Donald R Dengel, Karim T Sadak, Jill L Lee, Anne H Blaes, Daniel A Duprez, Joanna L Perkins, Julie A Ross, Aaron S Kelly
PURPOSE: Many adult survivors of childhood cancer are at high-risk of developing cardiovascular disease. Cancer therapy may cause damage to the vascular endothelium, thereby initiating atherosclerosis. Atorvastatin has been shown to improve endothelial function independent of reducing cholesterol, as well as reduce/slow arterial stiffness and thickening, yet has never been studied in childhood cancer survivors (CCS). METHODS: Twenty-seven young adult (age 26.8 ± 6...
August 30, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28853208/clinical-outcomes-and-toxicity-following-palliative-radiotherapy-for-childhood-cancers
#10
Kimberley S Mak, Stephanie W Lee, Tracy A Balboni, Karen J Marcus
BACKGROUND: Few reports of palliative radiotherapy (RT) for pedialltric malignancies have been published. We described clinical indications, outcomes, and toxicities for children who received palliative RT. PROCEDURE: Pediatric patients (age ≤18 years) treated with palliative RT for incurable cancer from January 1 2008 to February 26, 2014 were included. Diagnosis, details of RT, treatment response, toxicity, and survival were retrospectively reviewed. RESULTS: Forty-six patients received 76 RT courses...
August 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28837384/adverse-health-outcomes-and-associations-with-self-reported-general-health-in-childhood-lymphoma-survivors
#11
Inga M R Johannsdottir, Hanne Hamre, Sophie D Fosså, Jon Håvard Loge, Liv Drolsum, May Brit Lund, Lars Nordsletten, Cecilie Kiserud
BACKGROUND: The increased incidence of physical and psychosocial adverse health outcomes (AHOs) in childhood lymphoma survivors (CLSs) is well known, but these AHOs' association with self-reported general health is rarely described. AIM: We explored this association among long-term CLSs. METHODS: In 124 CLSs (Hodgkin: 81; non-Hodgkin: 43; median age: 33 years), physical AHOs were graded based on slightly modified common toxicity criteria for adverse effects (CTCAE)-4 recommendations (Grade 0-3)...
September 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28822593/decreased-expression-of-microrna-122-is-associated-with-an-unfavorable-prognosis-in-childhood-acute-myeloid-leukemia-and-function-analysis-indicates-a-therapeutic-potential
#12
Juan Yang, Yufang Yuan, Xiaochun Yang, Ze Hong, Lijuan Yang
MicroRNA (miR)-122 functions as a tumor suppressor in various human cancers. However, its involvement in childhood acute myeloid leukemia (AML) remains unknown. In this study, quantitative real-time PCR assay demonstrated that miR-122 expression in bone marrow specimens from AML children were significantly lower than that in non-malignant controls (P<0.001). Statistically, AML children with low miR-122 expression more frequently had large white blood cell count (P=0.022), French-American-British classification subtype M7 (P<0...
June 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28817372/financial-burden-in-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#13
Ryan D Nipp, Anne C Kirchhoff, Douglas Fair, Julia Rabin, Kelly A Hyland, Karen Kuhlthau, Giselle K Perez, Leslie L Robison, Gregory T Armstrong, Paul C Nathan, Kevin C Oeffinger, Wendy M Leisenring, Elyse R Park
Purpose Survivors of childhood cancer may experience financial burden as a result of health care costs, particularly because these patients often require long-term medical care. We sought to evaluate the prevalence of financial burden and identify associations between a higher percentage of income spent on out-of-pocket medical costs (≥ 10% of annual income) and issues related to financial burden (jeopardizing care or changing lifestyle) among survivors of childhood cancer and a sibling comparison group. Methods Between May 2011 and April 2012, we surveyed an age-stratified, random sample of survivors of childhood cancer and a sibling comparison group who were enrolled in the Childhood Cancer Survivor Study...
August 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28812191/improved-outcome-of-childhood-acute-myeloid-leukemia-in-an-eastern-european-country-lithuanian-experience
#14
Igne Kairiene, Ramune Pasauliene, Nadezda Lipunova, Goda Vaitkeviciene, Lina Rageliene, Jelena Rascon
The reported treatment outcomes of children treated for cancer in Eastern European countries are inferior to those in Northern/Western Europe. We hypothesized that recent survival rates could be comparable to the current standards and performed a population-based analysis of treatment outcome of childhood acute myeloid leukemia (AML) in Lithuania, a small Eastern European country. Children < 18 years old who were treated for AML from 2000 to 2013 were included (n = 54). Estimates of 5-year event-free (EFS5y) and overall survival (OS5y) rates were analyzed...
August 15, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28807009/adverse-mental-health-outcomes-in-breast-cancer-survivors-compared-to-women-who-did-not-have-cancer-systematic-review-protocol
#15
Helena Carreira, Rachael Williams, Martin Müller, Rhea Harewood, Krishnan Bhaskaran
BACKGROUND: Recent increasing trends in breast cancer incidence and survival have resulted in unprecedented numbers of cancer survivors in the general population. A cancer diagnosis may have a profound psychological impact, and breast cancer treatments often cause long-term physical sequelae, potentially affecting women's mental health. The aim of this systematic review is to identify and summarise all studies that have compared mental health outcomes in breast cancer survivors, versus women who did not have cancer...
August 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28802171/parental-occupational-exposure-to-benzene-and-the-risk-of-childhood-cancer-a-census-based-cohort-study
#16
Ben Daniel Spycher, Judith Eva Lupatsch, Anke Huss, Johannes Rischewski, Christina Schindera, Adrian Spoerri, Roel Vermeulen, Claudia Elisabeth Kuehni
BACKGROUND: Previous studies on occupational exposures in parents and cancer risks in their children support a link between solvents and paints with childhood leukaemia. Few studies have focused specifically on benzene. OBJECTIVES: To examine whether parental occupational exposure to benzene is associated with an increased cancer risk in a census-based cohort of children. METHODS: From a census-based cohort study in Switzerland, we included children aged <16years at national censuses (1990, 2000)...
August 9, 2017: Environment International
https://www.readbyqxmd.com/read/28801389/the-role-of-rehabilitation-measures-in-reintegration-of-children-with-brain-tumours-or-leukaemia-and-their-families-after-completion-of-cancer-treatment-a-study-protocol
#17
Mona Leandra Peikert, Laura Inhestern, Corinna Bergelt
INTRODUCTION: For ill children as well as for their parents and siblings, childhood cancer poses a major challenge. Little is known about the reintegration into daily life of childhood cancer survivors and their families. The aim of this prospective observational study is to further the understanding of the role of rehabilitation measures in the reintegration process of childhood leukaemia or brain tumour survivors and their family members after the end of cancer treatment. METHODS AND ANALYSIS: This prospective observational study consists of three study arms: a quantitative study in cooperation with three German paediatric oncological study registries (study arm 1), a quantitative study in cooperation with a rehabilitation clinic that offers a family-oriented paediatric oncological rehabilitation programme (study arm 2) and a qualitative study at 12-month follow-up including families from the study arms 1 and 2 (study arm 3)...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28798906/cerebral-sinovenous-thrombosis
#18
REVIEW
Rebecca Ichord
Cerebral sinovenous thrombosis (CSVT) is a rare but serious cerebrovascular disorder affecting children from the newborn period through childhood and adolescence. The incidence is estimated at 0.6/100,000/year, with 30-50% occurring in newborns. Causes are diverse and are highly age dependent. Acute systemic illness is the dominant risk factor among newborns. In childhood CSVT, acute infections of the head and neck such as mastoiditis are most common, followed by chronic underlying diseases such as nephrotic syndrome, cancer, and inflammatory bowel disease...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28795857/unmet-needs-of-adult-survivors-of-childhood-cancers-associations-with-developmental-stage-at-diagnosis-cognitive-impairment-and-time-from-diagnosis
#19
Joanne L Park, Yvonne Brandelli, K Brooke Russell, Kathleen Reynolds, Yong Li, Dean Ruether, Janine Giese-Davis
PURPOSE: Adult survivors of childhood cancers (ASCCs) are a unique and growing population. Because these individuals were diagnosed in childhood, their developmental stage at diagnosis may influence medical sequelae and perception of their cancer diagnosis and potentially result in long-term complications and challenges. Our aim was to determine how developmental stage, time since diagnosis, and cognitive impairment relate to Canadian ASCC distress and unmet needs. METHODS: Canadian ASCCs aged 19-77 years (N = 115) diagnosed between ages 0 and 5 (n = 25), 6 and 12 (n = 22), or 13 and 18 (n = 68) completed demographic, neurocognitive self-report, depression, and anxiety and unmet needs questionnaires...
August 10, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28792662/comparing-oncologic-outcomes-after-minimally-invasive-and-open-surgery-for-pediatric-neuroblastoma-and-wilms-tumor
#20
Brian Ezekian, Brian R Englum, Brian C Gulack, Kristy L Rialon, Jina Kim, Lindsay J Talbot, Obinna O Adibe, Jonathan C Routh, Elisabeth T Tracy, Henry E Rice
BACKGROUND: Minimally invasive surgery (MIS) has been widely adopted for common operations in pediatric surgery; however, its role in childhood tumors is limited by concerns about oncologic outcomes. We compared open and MIS approaches for pediatric neuroblastoma and Wilms tumor (WT) using a national database. METHODS: The National Cancer Data Base from 2010 to 2012 was queried for cases of neuroblastoma and WT in children ≤21 years old. Children were classified as receiving open or MIS surgery for definitive resection, with clinical outcomes compared using a propensity matching methodology (two open:one MIS)...
August 9, 2017: Pediatric Blood & Cancer
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