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https://www.readbyqxmd.com/read/29346666/gypsy-roma-and-traveller-access-to-and-engagement-with-health-services-a-systematic-review
#1
Alison McFadden, Lindsay Siebelt, Anna Gavine, Karl Atkin, Kerry Bell, Nicola Innes, Helen Jones, Cath Jackson, Haggi Haggi, Steve MacGillivray
Background: Gypsy, Roma and Traveller people represent the most disadvantaged minority groups in Europe, having the poorest health outcomes. This systematic review addressed the question of how Gypsy, Roma and Traveller people access healthcare and what are the best ways to enhance their engagement with health services. Methods: Searches were conducted in 21 electronic databases complemented by a focussed Google search. Studies were included if they had sufficient focus on Gypsy, Roma or Traveller populations; reported data pertinent to healthcare service use or engagement and were published in English from 2000 to 2015...
February 1, 2018: European Journal of Public Health
https://www.readbyqxmd.com/read/29346652/toward-rational-antibody-design-recent-advancements-in-molecular-dynamics-simulations
#2
Takefumi Yamashita
Because antibodies have become an important therapeutic tool, rational antibody design is a challenging issue involving various science and technology fields. From the computational aspect, many types of design-assist methods have been developed, but their accuracy is not fully satisfactory. Because of recent advancements in computational power, molecular dynamics (MD) simulation has become a helpful tool to trace the motion of proteins and to characterize their properties. Thus, MD simulation has been applied to various systems involving antigen-antibody complexes and has been shown to provide accurate insight into antigen-antibody interactions and dynamics at an atomic resolution...
January 15, 2018: International Immunology
https://www.readbyqxmd.com/read/29346638/standardized-languages-and-notations-for-graphical-modelling-of-patient-care-processes-a-systematic-review
#3
Pierpaolo Mincarone, Carlo Giacomo Leo, Maria Del Mar Trujillo-Martín, Jan Manson, Roberto Guarino, Giuseppe Ponzini, Saverio Sabina
Purpose: The importance of working toward quality improvement in healthcare implies an increasing interest in analysing, understanding and optimizing process logic and sequences of activities embedded in healthcare processes. Their graphical representation promotes faster learning, higher retention and better compliance. The study identifies standardized graphical languages and notations applied to patient care processes and investigates their usefulness in the healthcare setting. Data sources: Peer-reviewed literature up to 19 May 2016...
January 16, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29346632/diagnostic-and-prognostic-value-of-jc-virus-dna-in-plasma-in-progressive-multifocal-leukoencephalopathy
#4
Francesca Ferretti, Arabella Bestetti, Constantin T Yiannoutsos, Beverly S Musick, Simonetta Gerevini, Laura Passeri, Simona Bossolasco, Antonio Boschini, Diego Franciotta, Adriano Lazzarin, Paola Cinque
Background: Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease caused by the polyomavirus JC (JCV) affecting subjects with impaired immune system. While JCV-DNA detection in cerebrospinal fluid (CSF) is diagnostic of PML, the clinical significance of plasma JCV-DNA is still uncertain. Methods: We retrospectively analyzed plasma samples drawn from patients with PML close to disease onset, and controls without PML. In PML patients, we compared plasma JCV DNA detection and levels to: JCV DNA in the other biological samples, clinical and laboratory parameters and patients' survival...
January 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29346525/frailty-syndrome-and-genomic-instability-in-older-adults-suitability-of-the-cytome-micronucleus-assay-as-a-diagnostic-tool
#5
María Sánchez-Flores, Diego Marcos-Pérez, Laura Lorenzo-López, Ana Maseda, José C Millán-Calenti, Stefano Bonassi, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty, a condition involving increased risk of disability and mortality in older adults, has emerged as a reliable way to predict the effect of aging. Genomic instability may help to anticipate recognition of frail individuals and improving frailty outcomes. Our objective was to evaluate the potential of the micronucleus (MN) frequency, evaluated in lymphocytes and buccal cells, to anticipate frailty identification and improve diagnosis reliability. Our results, from a group of older adults over 65, showed that frail individuals had significantly higher frequencies of MN in lymphocytes (19...
January 13, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29346407/relaxin-reverses-inflammatory-and-immune-signals-in-aged-hearts
#6
Brian Martin, Beth Ann Gabris-Weber, Rajiv Reddy, Guillermo Romero, Ansuman Chattopadhyay, Guy Salama
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive remodeling in aging and HF...
2018: PloS One
https://www.readbyqxmd.com/read/29346387/inferring-the-risk-factors-behind-the-geographical-spread-and-transmission-of-zika-in-the-americas
#7
Lauren M Gardner, András Bóta, Karthik Gangavarapu, Moritz U G Kraemer, Nathan D Grubaugh
BACKGROUND: An unprecedented Zika virus epidemic occurred in the Americas during 2015-2016. The size of the epidemic in conjunction with newly recognized health risks associated with the virus attracted significant attention across the research community. Our study complements several recent studies which have mapped epidemiological elements of Zika, by introducing a newly proposed methodology to simultaneously estimate the contribution of various risk factors for geographic spread resulting in local transmission and to compute the risk of spread (or re-introductions) between each pair of regions...
January 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346365/the-iscb-student-council-internship-program-expanding-computational-biology-capacity-worldwide
#8
Jigisha Anupama, Margherita Francescatto, Farzana Rahman, Nazeefa Fatima, Dan DeBlasio, Avinash Kumar Shanmugam, Venkata Satagopam, Alberto Santos, Pandurang Kolekar, Magali Michaut, Emre Guney
Education and training are two essential ingredients for a successful career. On one hand, universities provide students a curriculum for specializing in one's field of study, and on the other, internships complement coursework and provide invaluable training experience for a fruitful career. Consequently, undergraduates and graduates are encouraged to undertake an internship during the course of their degree. The opportunity to explore one's research interests in the early stages of their education is important for students because it improves their skill set and gives their career a boost...
January 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29345916/monitoring-h2o2-inside-aspergillus-fumigatus-with-an-integrated-microelectrode-the-role-of-peroxiredoxin-protein-prx1
#9
Carla S Santos, Renata Bannitz-Fernandes, Alex S Lima, Carlos A Tairum, Iran Malavazi, Luis Eduardo S Netto, Mauro Bertotti
In vivo studies on the degradation of exogenous hydrogen peroxide (H2O2) in the microenvironment of Aspergillus fumigatus fungus were performed by using an integrated Pt microelectrode. Three A. fumigatus strains were used to confirm the role of the cytosolic protein Prx1 on the defense mechanism of this microorganism: a wild-type strain, capable to express the protein Prx1; a Δprx strain, whose gene prx1 was removed; and a complemented Δprx1::prx1+ strain derivatized from the Δprx and in which the gene prx1 was re-introduced...
January 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29345622/position-paper-on-nasal-obstruction-evaluation-and-treatment
#10
REVIEW
A Valero, A M Navarro, A Del Cuvillo, I Alobid, J R Benito, C Colás, G de Los Santos, R Fernández Liesa, A García-Lliberós, R González-Pérez, A Izquierdo-Domínguez, A Jurado-Ramos, M M Lluch-Bernal, J R Montserrat Gili, J Mullol, A Puiggròs Casas, M C Sánchez-Hernández, F Vega, J M Villacampa, M Armengot-Carceller, M T Dordal
Nasal obstruction (NO) is defined as the subjective perception of discomfort or difficulty in the passage of air through the nostrils. It is a common reason for consultation in primary and specialized care, and it may affect up to 30-40% of the population. It affects the quality of life (it especially disturbs sleep) and lowers work efficiency. The aim of this document is to agree on how to treat NO, establish a methodology for evaluating and diagnosing it, and define an individualized approach to its treatment...
January 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29345270/energetics-and-dynamics-of-the-non-natural-fluorescent-4ap-dap-base-pair
#11
Mohit Chawla, Ida Autiero, Romina Oliva, Luigi Cavallo
The fluorescent non-natural 4-aminophthalimide (4AP) base, when paired to the complementary 2,4-diaminopyrimidine (DAP) nucleobase, is accommodated in a B-DNA duplex being efficiently recognized and incorporated by DNA polymerases. To complement the experimental studies and rationalize the impact of the above non-natural bases on the structure, stability and dynamics of nucleic acid structures, we performed quantum mechanics (QM) calculations along with classical molecular dynamics (MD) simulations. QM calculations were initially focused on the geometry and energetics of the 4AP:DAP non-natural pair and of H-bonded base pairs between 4AP and all the natural bases in their classical Watson-Crick geometries...
January 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29345147/the-complexities-of-family-caregiving-at-work-a-mixed-methods-study
#12
Joseph E Gaugler, Deborah L Pestka, Heather Davila, Rebecca Sales, Greg Owen, Sarah A Baumgartner, Rocky Shook, Jane Cunningham, Maureen Kenney
The current project examined the impact of caregiving and caregiving-work conflict on employees' well-being. A sequential explanatory mixed-methods design (QUAN→qual) was utilized, and a total of 880 employees from a large health-care plan employer completed an online survey. Forty-five caregivers who completed the survey also participated in one of the five focus groups held 1 to 2 months later. Employed caregivers were significantly ( p < .05) more likely to indicate poorer physical and mental health than noncaregivers; among caregivers ( n = 370), caregiving-work conflict emerged as the most significant predictor of well-being and fully mediated the empirical relationship between burden and well-being...
January 1, 2018: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29345109/effectiveness-of-smartphone-technologies-on-glycaemic-control-in-patients-with-type-2-diabetes-systematic-review-with-meta-analysis-of-17-trials
#13
REVIEW
I X Y Wu, J C Y Kee, D E Threapleton, R Ma, V C K Lam, E K P Lee, S Y S Wong, V C H Chung
Patient education and behavioural interventions for self-management of type 2 diabetes mellitus (T2DM) are effective but place demands on manpower resources. This systematic review aimed to investigate the effectiveness of smartphone technologies (STs) for improving glycaemic control among T2DM patients. CENTRAL, MEDLINE, Embase, CINAHL and ScienceDirect were searched through December 2016. Randomized controlled trials comparing STs with usual diabetes care among T2DM patients and reporting change in glycated haemoglobin (HbA1c) level were included...
January 17, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29345075/genetic-analyses-of-linear-profiling-data-on-3-year-old-swedish-warmblood-horses
#14
Å Viklund, S Eriksson
A linear profiling protocol was introduced in 2013 at tests for 3-year-old Swedish Warmblood horses. In this protocol, traits are subjectively described on a nine-point linear scale from one biological extreme to the other. This complements the traditional scoring where horses are evaluated in relation to the breeding objective. This study aimed to investigate the suitability of the linear information for genetic evaluation. Data on 22 conformation traits, 17 movement traits, 14 jumping traits and one temperament trait from 3,410 horses tested between 2013 and 2016 were analysed using an animal model...
February 2018: Journal of Animal Breeding and Genetics, Zeitschrift Für Tierzüchtung und Züchtungsbiologie
https://www.readbyqxmd.com/read/29344910/mimesis-and-clinical-pictures-thinking-with-plato-and-broekman-through-the-production-and-meaning-of-images-of-disease
#15
Marjolein Oele
This paper contends, following Plato and Broekman, that (1) seeing images as images is crucial to theorizing medicine and that (2) considering clinical pictures as images of images is a much-needed epistemic complement to the domineering view that sees clinical pictures as mirrors of disease. This does not only offer epistemic, but also ethical benefits to individual patients, especially in those cases where patients suffer from chronic, debilitating, and terminal illnesses and where medicine provides no, or limited, answers in terms of treatment, intervention, and meaning...
January 17, 2018: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/29344374/cardioprotection-by-an-anti-masp-2-antibody-in-a-murine-model-of-myocardial-infarction
#16
James E Clark, Thomas Dudler, Michael S Marber, Wilhelm Schwaeble
Background: Myocardial ischaemia-reperfusion injury is a major cause of mortality and morbidity in the developed world. Many approaches have been investigated to counteract the pathological consequences associated with acute myocardial infarction (AMI) and cardiac remodelling. It is accepted that inflammation, and therefore activation of the complement pathway, is a crucial step in the pathogenesis of this injury, and many attempts have been made to ameliorate the infarction and consequent dysfunction using anticomplement therapy, with mixed success...
2018: Open Heart
https://www.readbyqxmd.com/read/29343892/first-two-bilateral-hand-transplantations-in-india-part-4-immediate-post-operative-care-immunosuppression-protocol-and-monitoring
#17
Subramania Iyer, Mohit Sharma, P Kishore, Jimmy Mathew, R Janarthanan, Raghuveer Reddy, Abhijeet Wakure, Sundeep Vijayaraghavan, S M Chetan Mali, Visakh Varma, Ashish Chaudhari, Swapnil Dhake, Akshay Omkumar, George Kurian, Rajesh Nair, Anil Mathew, Zachariah Paul, Malini Eapen, Lalitha Biswas
Introduction: Being able to counter immune-mediated rejection has for decades been the single largest obstacle for the progress of vascular composite allotransplantation (VCA). The human immune system performs the key role of differentiating the 'self ' from the 'non-self '. This, although is quintessential to eliminate or resist infections, also resists the acceptance of an allograft which it promptly recognises as 'non-self'. Materials and Methods: Pre-operative evaluation of the recipient evaluation included immunological assessment in the form of panel reactive antibodies (PRA), human leucocyte antigen (HLA) typing, donor-specific antibody detection assays (DSA) and complement-dependent cytotoxicity assays (CDC)...
May 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29343861/sensing-native-protein-solution-structures-using-a-solid-state-nanopore-unraveling-the-states-of-vegf
#18
Nitinun Varongchayakul, Diana Huttner, Mark W Grinstaff, Amit Meller
Monitoring individual proteins in solution while simultaneously obtaining tertiary and quaternary structural information is challenging. In this study, translocation of the vascular endothelial growth factor (VEGF) protein through a solid-state nanopore (ssNP) produces distinct ion-current blockade amplitude levels and durations likely corresponding to monomer, dimer, and higher oligomeric states. Upon changing from a non-reducing to a reducing condition, ion-current blockage events from the monomeric state dominate, consistent with the expected reduction of the two inter-chain VEGF disulfide bonds...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343682/intermittent-c1-inhibitor-deficiency-associated-with-recessive-inheritance-functional-and-structural-insight
#19
Sonia Caccia, Chiara Suffritti, Thomas Carzaniga, Romina Berardelli, Silvia Berra, Vincenzo Martorana, Annamaria Fra, Christian Drouet, Marco Cicardi
C1-inhibitor is a serine protease inhibitor (serpin) controlling complement and contact system activation. Gene mutations result in reduced C1-inhibitor functional plasma level causing hereditary angioedema, a life-threatening disorder. Despite a stable defect, the clinical expression of hereditary angioedema is unpredictable, and the molecular mechanism underlying this variability remains undisclosed. Here we report functional and structural studies on the Arg378Cys C1-inhibitor mutant found in a patient presenting reduced C1-inhibitor levels, episodically undergoing normalization...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343668/configuration-of-the-sugar-head-of-glycolipids-in-thylakoid-membranes
#20
Egi Tritya Apdila, Koichiro Awai
Glycolipids constitute the majority of membrane components in oxygenic photosynthetic organisms, whereas they are minor lipids in other organisms. In cyanobacteria, three glycolipids comprise ~90 mol% of the total lipids in thylakoid membranes, where photosynthetic electron transport occurs. Among these glycolipids, 80 mol% are galactolipids (monogalactosyldiacylglycerol and digalactosyldiacylglycerol). Galactolipids are well conserved in oxygenic photosynthetic organisms and are believed to be essential for the integrity of the membrane system...
January 17, 2018: Genes & Genetic Systems
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